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https://www.readbyqxmd.com/read/28680099/transcranial-random-noise-stimulation-and-cognitive-training-to-improve-learning-and-cognition-of-the-atypically-developing-brain-a-pilot-study
#1
Chung Yen Looi, Jenny Lim, Francesco Sella, Simon Lolliot, Mihaela Duta, Alexander Alexandrovich Avramenko, Roi Cohen Kadosh
Learning disabilities that affect about 10% of human population are linked to atypical neurodevelopment, but predominantly treated by behavioural interventions. Behavioural interventions alone have shown little efficacy, indicating limited success in modulating neuroplasticity, especially in brains with neural atypicalities. Even in healthy adults, weeks of cognitive training alone led to inconsistent generalisable training gains, or "transfer effects" to non-trained materials. Meanwhile, transcranial random noise stimulation (tRNS), a painless and more direct neuromodulation method was shown to further promote cognitive training and transfer effects in healthy adults without harmful effects...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28678547/referral-rates-of-postlingually-deafened-adult-hearing-aid-users-for-a-cochlear-implant-candidacy-assessment
#2
Valerie Looi, Cleo Bluett, Isabelle Boisvert
OBJECTIVE: The aims of this study were: to investigate the referral rates of postlingually deafened adult cochlear implant (CI) candidates from a hearing aid (HA) clinic for a CI candidacy assessment and to gain insight about factors influencing the referral pathways to CI assessments. DESIGN: Two methodologies were used: a retrospective cohort study reviewing clinical files and a questionnaire to clinicians. STUDY SAMPLE: The files of 1249 adult clients from the HA clinic who had average puretone hearing thresholds greater or equal to 65 dB HL in the better hearing ear and unaided phoneme recognition scores of less than 50% in both ears were reviewed...
July 5, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28673247/de-novo-transcriptome-analysis-shows-differential-expression-of-genes-in-salivary-glands-of-edible-bird-s-nest-producing-swiftlets
#3
Q H Looi, H Amin, I Aini, M Zuki, A R Omar
BACKGROUND: Edible bird's nest (EBN), produced from solidified saliva secretions of specific swiftlet species during the breeding season, is one of the most valuable animal by-products in the world. The composition and medicinal benefits of EBN have been extensively studied, however, genomic and transcriptomic studies of the salivary glands of these birds have not been conducted. RESULTS: The study described the transcriptomes of salivary glands from three swiftlet species (28 samples) generated by RNASeq...
July 3, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28642971/high-diversity-of-bacterial-communities-in-developmental-stages-of-bactrocera-carambolae-insecta-tephritidae-revealed-by-illumina-miseq-sequencing-of-16s-rrna-gene
#4
Hoi-Sen Yong, Sze-Looi Song, Kah-Ooi Chua, Phaik-Eem Lim
Bactrocera carambolae is a highly polyphagous fruit pest of agricultural importance. This study reports the bacterial communities associated with the developmental stages of B. carambolae. The microbiota of the developmental stages were investigated by targeted 16S rRNA gene (V3-V4 region) sequencing using the Illumina MiSeq. At 97% similarity, there were 19 bacterial phyla and unassigned bacteria, comprising 39 classes, 86 orders, 159 families and 311 genera. The bacterial composition varied among the specimens of developmental stage and across developmental stages as well as exuviae...
June 23, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28595430/sustained-effects-of-acupuncture-in-treatment-of-chronic-constipation
#5
EDITORIAL
Stephanie C Tjen-A-Looi, Liang-Wu Fu
No abstract text is available yet for this article.
April 17, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28582385/corrigendum-apoptotic-effect-of-novel-schiff-based-cdcl2-c14h21n3o2-complex-is-mediated-via-activation-of-the-mitochondrial-pathway-in-colon-cancer-cells
#6
Maryam Hajrezaie, Mohammadjavad Paydar, Chung Yeng Looi, Soheil Zorofchian Moghadamtousi, Pouya Hassandarvish, Muhammad Saleh Salga, Hamed Karimian, Keivan Shams, Maryam Zahedifard, Nazia Abdul Majid, Hapipah Mohd Ali, Mahmood Ameen Abdulla
This corrects the article DOI: 10.1038/srep09097.
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28550719/morphometric-analysis-of-thalamic-volume-in-progressive-supranuclear-palsy-in-vivo-evidence-of-regionally-specific-bilateral-thalamic-atrophy
#7
Brian D Power, David Jakabek, Mitchell Hunter-Dickson, Fiona A Wilkes, Danielle van Westen, Alexander F Santillo, Mark Walterfang, Dennis Velakoulis, Christer Nilsson, Jeffrey C L Looi
We investigated whether differences were detectable in the volume and shape of the dorsal thalamus on magnetic resonance imaging in patients with progressive supranuclear palsy (PSP). Manual segmentation of the left and right thalami on magnetic resonance imaging scans occurred in 22 patients with clinically diagnosed PSP and 23 healthy controls; thalamic volumes (left, right, total) were calculated. Between group differences were explored by multivariate analysis of co-variance, using age and intracranial volume as covariates...
May 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28484873/geo-accumulation-index-and-contamination-factors-of-heavy-metals-zn-and-pb-in-urban-river-sediment
#8
Hazzeman Haris, Ley Juen Looi, Ahmad Zaharin Aris, Nor Farhanna Mokhtar, Nur Ain Ayunie Ayob, Fatimah Md Yusoff, Abu Bakar Salleh, Sarva Mangala Praveena
The aim of the present study was to appraise the levels of heavy metal contamination (Zn and Pb) in sediment of the Langat River (Selangor, Malaysia). Samples were collected randomly from 15 sampling stations located along the Langat River. The parameters measured were pH, redox potential, salinity, electrical conductivity, loss of ignition, cation exchanges capacity (Na, Mg, Ca, K), and metal ions (Zn and Pb). The geo-accumulation index (I geo) and contamination factor (C f) were applied to determine and classify the magnitude of heavy metal pollution in this urban river sediment...
May 8, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28458525/rivastigmine-the-advantages-of-dual-inhibition-of-acetylcholinesterase-and-butyrylcholinesterase-and-its-role-in-subcortical-vascular-dementia-and-parkinson-s-disease-dementia
#9
REVIEW
Nagaendran Kandiah, Ming-Chyi Pai, Vorapun Senanarong, Irene Looi, Encarnita Ampil, Kyung Won Park, Ananda Krishna Karanam, Stephen Christopher
Several studies have demonstrated clinical benefits of sustained cholinesterase inhibition with rivastigmine in Alzheimer's disease (AD) and Parkinson's disease dementia (PDD). Unlike donepezil and galantamine that selectively inhibit acetylcholinesterase (AChE; EC 3.1.1.7), rivastigmine is a unique cholinesterase inhibitor with both AChE and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibitory activity. Rivastigmine is also available as transdermal patch that has been approved by the US Food and Drug Administration for the treatment of mild, moderate, and severe AD as well as mild-to-moderate PDD...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28453984/functional-and-genetic-evidence-that-nucleoside-transport-is-highly-conserved-in-leishmania-species-implications-for-pyrimidine-based-chemotherapy
#10
Khalid J H Alzahrani, Juma A M Ali, Anthonius A Eze, Wan Limm Looi, Daniel N A Tagoe, Darren J Creek, Michael P Barrett, Harry P de Koning
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various Leishmania species possess similar pyrimidine transporters capable of drug uptake. Here, we report a comprehensive characterization of pyrimidine transport in L. major and L. mexicana. In both species, two transporters for uridine/adenosine were detected, one of which also transported uracil and the antimetabolites 5-fluoruracil (5-FU) and 5F,2'deoxyuridine (5F,2'dUrd), and was designated uridine-uracil transporter 1 (UUT1); the other transporter mediated uptake of adenosine, uridine, 5F,2'dUrd and thymidine and was designated Nucleoside Transporter 1 (NT1)...
August 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28449020/s-pneumoniae-purulent-pericarditis-in-the-setting-of-community-acquired-pneumonia
#11
Andrew Chatfield, Timothy Glenie, Sarah Fitzsimons, Krish Chaudhuri, Khang-Li Looi
No abstract text is available yet for this article.
April 28, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28436230/time-and-relative-dimensions-in-syndromology-towards-endophenotypes-in-neurology-psychiatry-and-in-between
#12
Jeffrey Cl Looi, Alexander F Santillo
No abstract text is available yet for this article.
April 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28359511/adding-defibrillation-therapy-to-cardiac%C3%A2-resynchronization-on-the-basis%C3%A2-of%C3%A2-the-myocardial%C3%A2-substrate
#13
MULTICENTER STUDY
Sérgio Barra, Serge Boveda, Rui Providência, Nicolas Sadoul, Rudolf Duehmke, Christian Reitan, Rasmus Borgquist, Kumar Narayanan, Françoise Hidden-Lucet, Didier Klug, Pascal Defaye, Daniel Gras, Frédéric Anselme, Christophe Leclercq, Jean-Sébastien Hermida, Jean-Claude Deharo, Khang-Li Looi, Anthony W Chow, Munmohan Virdee, Simon Fynn, Jean-Yves Le Heuzey, Eloi Marijon, Sharad Agarwal
BACKGROUND: Patients with nonischemic dilated cardiomyopathy (DCM) may be at lower risk for ventricular arrhythmias compared with those with ischemic cardiomyopathy (ICM). In addition, DCM has been identified as a predictor of positive response to cardiac resynchronization therapy (CRT). OBJECTIVES: The aim of this study was to investigate the impact of an additional implantable cardioverter-defibrillator over CRT, according to underlying heart disease, in a large study group of primary prevention patients with heart failure...
April 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28347653/cytochrome-c-oxidase-subunit-i-haplotype-diversity-of-angiostrongylus-cantonensis-nematoda-angiostrongylidae
#14
Praphathip Eamsobhana, Sze-Looi Song, Hoi-Sen Yong, Anchana Prasartvit, Sudarat Boonyong, Anchalee Tungtrongchitr
The rat lungworm Angiostrongylus cantonensis is a food-borne zoonotic parasite of public health importance worldwide. It is the primary etiologic agent of eosinophilic meningitis and eosinophilic meningoencephalitis in humans in many countries. It is highly endemic in Thailand especially in the northeast region. In this study, A. cantonensis adult worms recovered from the lungs of wild rats in different geographical regions/provinces in Thailand were used to determine their haplotype by means of the mitochondrial partial cytochrome c oxidase subunit I (COI) gene sequence...
March 27, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28257283/presentation-of-coefficient-of-variation-for-bioequivalence-sample-size-calculation%C3%A2
#15
Yi Lin Lee, Wen Yao Mak, Irene Looi, Jia Woei Wong, Kah Hay Yuen
The current study aimed to further contribute information on intrasubject coefficient of variation (CV) from 43 bioequivalence studies conducted by our center. Consistent with Yuen et al. (2001), current work also attempted to evaluate the effect of different parameters (AUC0-t, AUC0-∞, and Cmax) used in the estimation of the study power. Furthermore, we have estimated the number of subjects required for each study by looking at the values of intrasubject CV of AUC0-∞ and have also taken into consideration the minimum sample-size requirement set by the US FDA...
March 3, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28246074/delirium-after-mechanical-ventilation-in-intensive-care-units-the-cognitive-and-psychosocial-assessment-capa-study-protocol
#16
Daniella Bulic, Michael Bennett, Helen Rodgers, Mary Nourse, Patrick Rubie, Jeffrey Cl Looi, Frank Van Haren
BACKGROUND: In the intensive care unit (ICU), critical illness delirium occurs in the context of multiple comorbidities, multi-organ failure, and invasive management techniques, such as mechanical ventilation, sedation, and lack of sleep. Delirium is characterized by an acute confusional state defined by fluctuating mental status, inattention, and either disorganized thinking or an altered level of consciousness. The long-term cognitive and psychosocial function of patients that experience delirium in the ICU is of crucial interest because preliminary data suggest a strong association between ICU-related delirium and long-term cognitive impairment...
February 28, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28229272/prophylactic-implantable-cardioverter-defibrillator-in-heart-failure-the-growing-evidence-for-all-or-primum-non-nocere-for-some
#17
REVIEW
Khang-Li Looi, Nigel Lever, Anthony Tang, Sharad Agarwal
Heart failure (HF) is a common health problem and has reached epidemic in many western countries. Despite the current era of HF treatment, the risk of sudden cardiac death (SCD) in HF remains significant. Implantable cardioverter defibrillator (ICD) support has been shown to reduce the risk of SCD in patients with HF and impaired left ventricular function. Prophylactic ICD implantation in HF patients seems a logical step to reduce mortality through a reduction in SCD. However, ICD implantation is an invasive procedure, and both short- and long-term complications can occur...
February 23, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28158414/an-essential-pathology-package-for-low-and-middle-income-countries
#18
Kenneth A Fleming, Mahendra Naidoo, Michael Wilson, John Flanigan, Susan Horton, Modupe Kuti, Lai Meng Looi, Chris Price, Kun Ru, Abdul Ghafur, Jianxiang Wang, Nestor Lago
Objectives: We review the current status of pathology services in low- and middle-income countries and propose an “essential pathology package” along with estimated costs. The purpose is to provide guidance to policy makers as countries move toward universal health care systems. Methods: Five key themes were reviewed using existing literature (role of leadership; education, training, and continuing professional development; technology; accreditation, management, and quality standards; and reimbursement systems)...
January 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28149676/genomic-insight-into-pathogenicity-of-dematiaceous-fungus-corynespora-cassiicola
#19
Hong Keat Looi, Yue Fen Toh, Su Mei Yew, Shiang Ling Na, Yung-Chie Tan, Pei-Sin Chong, Jia-Shiun Khoo, Wai-Yan Yee, Kee Peng Ng, Chee Sian Kuan
Corynespora cassiicola is a common plant pathogen that causes leaf spot disease in a broad range of crop, and it heavily affect rubber trees in Malaysia (Hsueh, 2011; Nghia et al., 2008). The isolation of UM 591 from a patient's contact lens indicates the pathogenic potential of this dematiaceous fungus in human. However, the underlying factors that contribute to the opportunistic cross-infection have not been fully studied. We employed genome sequencing and gene homology annotations in attempt to identify these factors in UM 591 using data obtained from publicly available bioinformatics databases...
2017: PeerJ
https://www.readbyqxmd.com/read/28145498/unraveling-the-cytotoxicity-and-metabolic-pathways-of-binary-natural-deep-eutectic-solvent-systems
#20
Yves Paul Mbous, Maan Hayyan, Won Fen Wong, Chung Yeng Looi, Mohd Ali Hashim
In this study, the anticancer potential and cytotoxicity of natural deep eutectic solvents (NADESs) were assessed using HelaS3, PC3, A375, AGS, MCF-7, and WRL-68 hepatic cell lines. NADESs were prepared from choline chloride, fructose, or glucose and compared with an N,N-diethyl ethanolammonium chloride:triethylene glycol DES. The NADESs (98 ≤ EC50 ≥ 516 mM) were less toxic than the DES (34 ≤ EC50 ≥ 120 mM). The EC50 values of the NADESs were significantly higher than those of the aqueous solutions of their individual components but were similar to those of the aqueous solutions of combinations of their chief elements...
February 1, 2017: Scientific Reports
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