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https://www.readbyqxmd.com/read/29147850/the-tear-cytokine-profile-in-patients-with-active-graves-orbitopathy
#1
Morgan Yang, Yvonne Chung, Stephanie Lang, Nobuyo Yawata, Lay Leng Seah, Audrey Looi
PURPOSE: The primary aim of this study is to isolate cytokines specific for active Graves' orbitopathy (GO) in the tears of affected patients. The secondary aim is to identify other cytokines of interest and to look at the profile of their levels over time. METHODS: This is a prospective pilot study conducted at the Singapore National Eye Centre. A total of 10 patients with active GO and 10 patients from each of 3 control groups were recruited. The 3 control groups were the following: age-matched normal female patients, patients with GO who were clinically inactive and patients with bilateral viral conjunctivitis...
November 16, 2017: Endocrine
https://www.readbyqxmd.com/read/29063107/evidence-based-blood-pressure-reducing-actions-of-electroacupuncture-mechanisms-and-clinical-application
#2
John C Longhurst, Stephanie C Tjen-A-Looi
Hypertension is a serious world-wide health problem as it increases cardiovascular atherosclerotic risk, stroke and attending morbidity and mortality. Both systolic and diastolic blood pressures and particularly systolic pressure increase with aging. The downsides from pharmacological therapy have led to consideration of additional treatments, including acupuncture, which evokes endogenous neural-hormonal systems to lower blood pressure. Using basic science studies to guide clinical approaches to research, it is apparent that low frequency, low intensity electroacupuncture reduces sympathetic outflow in approximately 70% of patients with mild to moderate hypertension who are off antihypertensive drugs...
October 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29060884/novel-force-sensing-system-for-minimally-invasive-surgical-instruments
#3
Justin Wee, Matthew Kang, Peter Francis, Robert Brooks, Leigh Masotti, Daniel Villavicencio, Thomas Looi, Georges Azzie, James Drake, J Ted Gerstle
Mastering proper force manipulation in minimally invasive surgery can take many years. Improper force control can lead to necrosis, infection, and scarring. This paper describes a novel system to measure, log, and display external forces at the distal end of minimally invasive surgical instruments in real-time. The system, comprising of a Force- Sensing Sleeve, Bluetooth electronics module, and an Android mobile application. A sensorized 5 mm minimally invasive surgical needle holder was evaluated for bending force accuracy, linearity, and repeatability in six directions...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060498/pca-mlp-svm-distinction-of-salivary-raman-spectra-of-dengue-fever-infection
#4
A R M Radzol, Khuan Y Lee, W Mansor, P S Wong, I Looi
Dengue fever (DF) is a disease of major concern caused by flavivirus infection. Delayed diagnosis leads to severe stages, which could be deadly. Of recent, non-structural protein (NS1) has been acknowledged as a biomarker, alternative to immunoglobulins for early detection of dengue in blood. Further, non-invasive detection of NS1 in saliva makes the approach more appealing. However, since its concentration in saliva is less than blood, a sensitive and specific technique, Surface Enhanced Raman Spectroscopy (SERS), is employed...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28990407/clinical-research-in-an-academic-psychiatry-department-some-general-principles-and-case-studies
#5
Philip Keightley, Paul Maguire, Rebecca E Reay, Jeffrey C Cubis, Peggy Craigie, Jeffrey Cl Looi
OBJECTIVE: This paper gives guidance for developing collaborative clinical research within an academic psychiatry department. METHODS: We describe the experience at the Australian National University Medical School, and present three case studies. RESULTS: The results reveal that general principles include, but are not limited to, intellectual curiosity, mentorship, collaboration and protected time. CONCLUSIONS: We conclude that a particular strength of a new research department at a medical school may be close collaborative research within clinical settings...
October 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28967276/salt-in-the-soul-steel-in-the-eye-and-caution-towards-the-winds-a-mariner-s-guide-for-navigating-a-new-academic-psychiatry-department
#6
Jeffrey Cl Looi, Daniel Bonner, Paul Maguire, Raj Parige, Michael Tedeschi, Jeffrey C Cubis, Bjorn Cartledge, Philip Keightley, Rebecca E Reay, Peggy Craigie
OBJECTIVES: This paper describes principles and advice regarding the development of a new academic psychiatry department within a medical school for aspiring academic psychiatrists. We describe general principles based on the experience of the foundation of the Academic Unit of Psychiatry and Addiction Medicine at the Australian National University Medical School. CONCLUSIONS: Perspicacious leadership and organisation are the foundation for an academic psychiatry department which delivers teaching, research and broader intellectual engagement with the medical and broader community...
September 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28915115/anti-arthritic-and-gastroprotective-activities-of-ardisia-crispa-root-partially-mediated-via-its-antioxidant-effect
#7
Roslida Abdul Hamid, Lau Moi Fong, Yeong Looi Ting
Background Ardisia crispa Thunb A.DC (Myrsinaceae), commonly known as "hen's eyes", has been traditionally used in treating various inflammatory diseases. The present study evaluated anti-arthritic, gastroprotective and antioxidant activities of Ardisia crispa root hexane extract (ACRH) in various animal models. Methods Anti-arthritic activity was evaluated in complete Freund adjuvant (CFA)-induced adjuvant arthritis and gastroprotective effect was studied in the ethanol-induced ulcer model in rats. ACRH was further isolated to yield quinone-rich fraction (QRF) and both were analyzed for their total phenolic content, total flavonoid content and antioxidant activities in various antioxidant assays...
September 14, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28865324/the-impact-of-apoa5-apob-apoc3-and-abca1-gene-polymorphisms-on-ischemic-stroke-evidence-from-a-meta-analysis
#8
Anthony Au, Lyn R Griffiths, Looi Irene, Cheah Wee Kooi, Loo Keat Wei
BACKGROUND AND AIMS: Genetic studies have been reported on the association between APOA5, APOB, APOC3 and ABCA1 gene polymorphisms and ischemic stroke, but results remain controversial. Hence, this meta-analysis aimed to infer the causal relationships of APOA5 (rs662799, rs3135506), APOB (rs693, rs1042031, rs1801701), APOC3 (rs4520, rs5128, rs2854116, rs2854117) and ABCA1 rs2230806 with ischemic stroke risk. METHODS: A systematic review was performed for all the articles retrieved from multiple databases, up until March 2017...
August 19, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28814208/the-doctor-as-an-expert-apprentice-journeyman-or-master
#9
Jeffrey Cl Looi, Choong-Siew Yong
No abstract text is available yet for this article.
August 21, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28774257/a-case-of-non-union-of-ulna-fracture-managed-with-tibial-strut-cortico-cancellous-bone-grafting-in-a-paediatric-patient
#10
Collin S K Looi, Roohi S A, Ranjit Singh Gill
Forearm fractures in children complicated with non-union are uncommon. Various methods have previously been reported to manage this condition. Well documented techniques would include iliac crest grafting, cancellous insert grafting, ulnar segment grafting, cortical tibial grafting, vascularized fibular grafting and bone transport by ring fixation. The authors present a case of a child with an atrophic non-union of the ulna who was successfully treated with a cortico-cancellous tibial strut bone graft.
September 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28760411/polymorphisms-of-mthfr-enos-ace-agt-apoe-pon1-pde4d-and-ischemic-stroke-meta-analysis
#11
Loo Keat Wei, Anthony Au, Saras Menon, Lyn R Griffiths, Cheah Wee Kooi, Looi Irene, Jiangyang Zhao, Chaeyoung Lee, Avdonina Maria Alekseevna, Muhammad Radzi Abdul Hassan, Zariah Abdul Aziz
INTRODUCTION: The association between ischemic stroke and genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR; 677C>T and 1298A>C), endothelial nitric oxide synthase (eNOS; -786T>C, +894G>T, and variable number tandem repeat [VNTR]), phosphodiesterase 4D (PDE4D; SNPs 83 and 87), angiotensin-converting enzyme (ACE) I/D, angiotensinogen (AGT) 235M>T, paraoxonase 1 (PON1) 192Q>R, and apolipoprotein E (ApoE) ε2ε3ε4 remains inconclusive. Therefore, this updated meta-analysis aimed to clarify the presumed influence of genetic polymorphisms on ischemic stroke by meta-analyzing the comprehensive coverage of all individual association studies...
November 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28752810/speech-recognition-outcomes-after-cochlear-reimplantation-surgery
#12
Mariana Reis, Isabelle Boisvert, Valerie Looi, Melville da Cruz
This study compares speech recognition outcomes before and after cochlear reimplantation surgery, in relation to clinical factors known before and at time of surgery. Between 2006 and 2015, 2,055 adult cochlear implant surgeries were conducted at this center, of which 87 were reimplantation surgeries (4.2%). Speech recognition scores (SRS) assessed before and after reimplantation were available for 54 adults. Overall, SRS measured after reimplantation were similar to the best SRS obtained by the patient and greater than the last SRS measured before surgery...
January 2017: Trends in Hearing
https://www.readbyqxmd.com/read/28680099/transcranial-random-noise-stimulation-and-cognitive-training-to-improve-learning-and-cognition-of-the-atypically-developing-brain-a-pilot-study
#13
Chung Yen Looi, Jenny Lim, Francesco Sella, Simon Lolliot, Mihaela Duta, Alexander Alexandrovich Avramenko, Roi Cohen Kadosh
Learning disabilities that affect about 10% of human population are linked to atypical neurodevelopment, but predominantly treated by behavioural interventions. Behavioural interventions alone have shown little efficacy, indicating limited success in modulating neuroplasticity, especially in brains with neural atypicalities. Even in healthy adults, weeks of cognitive training alone led to inconsistent generalisable training gains, or "transfer effects" to non-trained materials. Meanwhile, transcranial random noise stimulation (tRNS), a painless and more direct neuromodulation method was shown to further promote cognitive training and transfer effects in healthy adults without harmful effects...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28678547/referral-rates-of-postlingually-deafened-adult-hearing-aid-users-for-a-cochlear-implant-candidacy-assessment
#14
Valerie Looi, Cleo Bluett, Isabelle Boisvert
OBJECTIVE: The aims of this study were: to investigate the referral rates of postlingually deafened adult cochlear implant (CI) candidates from a hearing aid (HA) clinic for a CI candidacy assessment and to gain insight about factors influencing the referral pathways to CI assessments. DESIGN: Two methodologies were used: a retrospective cohort study reviewing clinical files and a questionnaire to clinicians. STUDY SAMPLE: The files of 1249 adult clients from the HA clinic who had average puretone hearing thresholds greater or equal to 65 dB HL in the better hearing ear and unaided phoneme recognition scores of less than 50% in both ears were reviewed...
July 5, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28673247/de-novo-transcriptome-analysis-shows-differential-expression-of-genes-in-salivary-glands-of-edible-bird-s-nest-producing-swiftlets
#15
Q H Looi, H Amin, I Aini, M Zuki, A R Omar
BACKGROUND: Edible bird's nest (EBN), produced from solidified saliva secretions of specific swiftlet species during the breeding season, is one of the most valuable animal by-products in the world. The composition and medicinal benefits of EBN have been extensively studied, however, genomic and transcriptomic studies of the salivary glands of these birds have not been conducted. RESULTS: The study described the transcriptomes of salivary glands from three swiftlet species (28 samples) generated by RNASeq...
July 3, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28642971/high-diversity-of-bacterial-communities-in-developmental-stages-of-bactrocera-carambolae-insecta-tephritidae-revealed-by-illumina-miseq-sequencing-of-16s-rrna-gene
#16
Hoi-Sen Yong, Sze-Looi Song, Kah-Ooi Chua, Phaik-Eem Lim
Bactrocera carambolae is a highly polyphagous fruit pest of agricultural importance. This study reports the bacterial communities associated with the developmental stages of B. carambolae. The microbiota of the developmental stages were investigated by targeted 16S rRNA gene (V3-V4 region) sequencing using the Illumina MiSeq. At 97% similarity, there were 19 bacterial phyla and unassigned bacteria, comprising 39 classes, 86 orders, 159 families and 311 genera. The bacterial composition varied among the specimens of developmental stage and across developmental stages as well as exuviae...
September 2017: Current Microbiology
https://www.readbyqxmd.com/read/28595430/sustained-effects-of-acupuncture-in-treatment-of-chronic-constipation
#17
EDITORIAL
Stephanie C Tjen-A-Looi, Liang-Wu Fu
No abstract text is available yet for this article.
April 17, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28582385/corrigendum-apoptotic-effect-of-novel-schiff-based-cdcl2-c14h21n3o2-complex-is-mediated-via-activation-of-the-mitochondrial-pathway-in-colon-cancer-cells
#18
Maryam Hajrezaie, Mohammadjavad Paydar, Chung Yeng Looi, Soheil Zorofchian Moghadamtousi, Pouya Hassandarvish, Muhammad Saleh Salga, Hamed Karimian, Keivan Shams, Maryam Zahedifard, Nazia Abdul Majid, Hapipah Mohd Ali, Mahmood Ameen Abdulla
This corrects the article DOI: 10.1038/srep09097.
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28550719/morphometric-analysis-of-thalamic-volume-in-progressive-supranuclear-palsy-in-vivo-evidence-of-regionally-specific-bilateral-thalamic-atrophy
#19
Brian D Power, David Jakabek, Mitchell Hunter-Dickson, Fiona A Wilkes, Danielle van Westen, Alexander F Santillo, Mark Walterfang, Dennis Velakoulis, Christer Nilsson, Jeffrey C L Looi
We investigated whether differences were detectable in the volume and shape of the dorsal thalamus on magnetic resonance imaging in patients with progressive supranuclear palsy (PSP). Manual segmentation of the left and right thalami on magnetic resonance imaging scans occurred in 22 patients with clinically diagnosed PSP and 23 healthy controls; thalamic volumes (left, right, total) were calculated. Between group differences were explored by multivariate analysis of co-variance, using age and intracranial volume as covariates...
May 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28484873/geo-accumulation-index-and-contamination-factors-of-heavy-metals-zn-and-pb-in-urban-river-sediment
#20
Hazzeman Haris, Ley Juen Looi, Ahmad Zaharin Aris, Nor Farhanna Mokhtar, Nur Ain Ayunie Ayob, Fatimah Md Yusoff, Abu Bakar Salleh, Sarva Mangala Praveena
The aim of the present study was to appraise the levels of heavy metal contamination (Zn and Pb) in sediment of the Langat River (Selangor, Malaysia). Samples were collected randomly from 15 sampling stations located along the Langat River. The parameters measured were pH, redox potential, salinity, electrical conductivity, loss of ignition, cation exchanges capacity (Na, Mg, Ca, K), and metal ions (Zn and Pb). The geo-accumulation index (I geo) and contamination factor (C f) were applied to determine and classify the magnitude of heavy metal pollution in this urban river sediment...
May 8, 2017: Environmental Geochemistry and Health
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