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https://www.readbyqxmd.com/read/29752102/cyclodextrin-and-dendrimer-conjugated-graphene-oxide-as-a-nanocarrier-for-the-delivery-of-selected-chemotherapeutic-and-photosensitizing-agents
#1
Ampornphan Siriviriyanun, Ya-Ju Tsai, Siew Hui Voon, Siaw Fui Kiew, Toyoko Imae, Lik Voon Kiew, Chung Yeng Looi, Won Fen Wong, Hong Boon Lee, Lip Yong Chung
In this study, nanohybrid materials consisting of graphene oxide (GO), β‑cyclodextrin (CD) and poly(amido amine) dendrimer (DEN) were successfully prepared by covalent bonding. GO-CD and GO-CD-DEN were found to be potential nanocarriers for anticancer drugs including chemotherapeutics (doxorubicin (DOX), camptothecin (CPT)) and photosensitizer (protoporphyrin IX (PpIX)). GO-CD possessed 1.2 times higher DOX-loading capacity than GO due to inclusion of additional DOX to the CD. The drug loading on GO-CD-DEN increased in the order: DOX < PpIX < CPT...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29737197/inflammatory-bowel-disease-related-fatigue-is-correlated-with-depression-and-gender
#2
Philip Keightley, Rebecca E Reay, Paul Pavli, Jeffrey Cl Looi
OBJECTIVES: Fatigue is a common and disabling problem in inflammatory bowel disease. We sought to explore the possible determinants of inflammatory bowel disease-associated fatigue including demographic, psychological and disease variables. METHODS: Surveys were distributed to 100 patients undergoing infliximab infusion for inflammatory bowel disease in an infusion lounge, assessing attachment style (Experiences in Close Relationships Revised scale), fatigue (Functional Assessment of Chronic Illness Therapy Fatigue - Fatigue Subscore), and depression and anxiety (Hospital Anxiety and Depression Scale)...
May 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29736692/design-modelling-and-teleoperation-of-a-2-mm-diameter-compliant-instrument-for-the-da-vinci-platform
#3
P Francis, K W Eastwood, V Bodani, T Looi, J M Drake
This work explores the feasibility of creating and accurately controlling an instrument for robotic surgery with a 2 mm diameter and a three degree-of-freedom (DoF) wrist which is compatible with the da Vinci platform. The instrument's wrist is composed of a two DoF bending notched-nitinol tube pattern, for which a kinematic model has been developed. A base mechanism for controlling the wrist is designed for integration with the da Vinci Research Kit. A basic teleoperation task is successfully performed using two of the miniature instruments...
May 7, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29722130/esophageal-squamous-cell-carcinoma-in-a-malaysian-cohort-shows-a-lack-of-association-with-human-papillomavirus
#4
Phaik-Leng Cheah, Cing-Chai Koh, Tsung Fei Khang, Khean-Lee Goh, Peng-Choong Lau, Kin-Fah Chin, Kean-Hooi Teoh, Yen-Fa Toh, Lai-Meng Looi
OBJECTIVE: Whether the human papillomavirus (HPV) is associated with esophageal cancer has been controversial and there has been no report to date on this in Malaysians or other South East Asian populations. With an age-standardized incidence rate (ASR) of 2 per 100,000, esophageal cancers are not common amongst Malaysians, but are nevertheless important due to its poor prognosis. METHODS: Sixty-seven esophageal squamous cell carcinoma (ESCC), histologically-diagnosed between 1st January 2004 and 31st December 2014 at the Department of Pathology, University of Malaya Medical Center, Malaysia were considered for HPV analysis using 2 commercially-available methods, PCR with flow-through hybridization (21 HPV GenoArray Diagnostic Kit; Hybribio, Hong Kong) and multiplex real-time PCR (Anyplex II HPV28 Detection; Seegene, Korea)...
May 2, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29721113/long-term-outcomes-of-heart-failure-patients-who-received-primary-prevention-implantable-cardioverter-defibrillator-an-observational-study
#5
Khang-Li Looi, Karishma Sidhu, Lisa Cooper, Liane Dawson, Debbie Slipper, Andrew Gavin, Nigel Lever
Background: Implantable cardioverter-defibrillator (ICD) therapy is indicated for selected heart failure patients for the primary prevention of sudden cardiac death. Little is known about the outcomes in patients selected for primary prevention device therapy in the northern region of New Zealand. Method: Heart failure patients with systolic dysfunction who underwent primary prevention ICD/cardiac resynchronization therapy-defibrillator (CRT-D) implantation between January 1, 2007, and June 1, 2015, were included...
February 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29687724/huntington-s-disease-managing-neuropsychiatric-symptoms-in-huntington-s-disease
#6
Samantha M Loi, Mark Walterfang, Dennis Velakoulis, Jeffrey Cl Looi
OBJECTIVES: This clinical update review focuses on the management of the neuropsychiatric manifestations of Huntington's disease (HD). The review highlights current issues regarding pharmacological and non-pharmacological treatment, putative therapeutics and recent relevant research findings in this area. CONCLUSIONS: Neuropsychiatric symptoms may precede the classic motor clinical symptoms of HD (prodromal HD) by decades and cause significant functional impairment...
April 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29671334/alzheimer-disease-non-pharmacological-and-pharmacological-management-of-cognition-and-neuropsychiatric-symptoms
#7
Samantha M Loi, Dhamidhu Eratne, Wendy Kelso, Dennis Velakoulis, Jeffrey Cl Looi
OBJECTIVES: This clinical update review focuses on the management of cognition and the neuropsychiatric features of Alzheimer's disease (AD) and highlights current issues regarding pharmacological and non-pharmacological treatment, putative therapeutics and recent relevant research findings in this area. CONCLUSIONS: AD is a neurodegenerative progressive condition characterised by cognitive impairment and functional decline. Most people with AD will demonstrate neuropsychiatric features, better known as behavioural and psychological symptoms of dementia (BPSD)...
March 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29614878/alzheimer-s-disease-paper-1-clinical-update-on-epidemiology-pathophysiology-and-diagnosis
#8
Dhamidhu Eratne, Samantha M Loi, Sarah Farrand, Wendy Kelso, Dennis Velakoulis, Jeffrey Cl Looi
OBJECTIVES: To provide a clinical update for general psychiatrists on the assessment and diagnosis of Alzheimer's disease (AD), highlighting current issues regarding epidemiology, risk factors and pathophysiology from recent relevant research findings. CONCLUSIONS: Psychiatrists can apply their skills and training in the diagnosis of AD, which is based upon a comprehensive assessment comprising history, investigations, and cognitive and functional assessment, guided by accepted diagnostic criteria...
March 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29600894/dr-john-longhurst-m-d-ph-d-1947-2018
#9
Stephanie C Tjen-A-Looi, Christopher A Longhurst
No abstract text is available yet for this article.
March 30, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29579024/assessing-technical-performance-and-determining-the-learning-curve-in-cleft-palate-surgery-using-a-high-fidelity-cleft-palate-simulator
#10
Dale J Podolsky, David M Fisher, Karen W Wong, Peter Szasz, Thomas Looi, James M Drake, Christopher R Forrest
INTRODUCTION: Technical skills assessment can provide objective measures of surgical performance. This study assessed technical performance in cleft palate repair using a newly developed assessment tool and high fidelity cleft palate simulator through a longitudinal simulation training exercise. METHODS: Three residents performed five and one resident performed nine consecutive endoscopically recorded cleft palate repairs using a cleft palate simulator. Two fellows in pediatric plastic surgery and two expert cleft surgeons also performed recorded simulated repairs...
March 19, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29555381/striatal-changes-in-parkinson-disease-an-investigation-of-morphology-functional-connectivity-and-their-relationship-to-clinical-symptoms
#11
Conor Owens-Walton, David Jakabek, Xiaozhen Li, Fiona A Wilkes, Mark Walterfang, Dennis Velakoulis, Danielle van Westen, Jeffrey C L Looi, Oskar Hansson
We sought to investigate morphological and resting state functional connectivity changes to the striatal nuclei in Parkinson disease (PD) and examine whether changes were associated with measures of clinical function. Striatal nuclei were manually segmented on 3T-T1 weighted MRI scans of 74 PD participants and 27 control subjects, quantitatively analysed for volume, shape and also functional connectivity using functional MRI data. Bilateral caudate nuclei and putamen volumes were significantly reduced in the PD cohort compared to controls...
March 7, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29550030/delivering-modern-high-quality-affordable-pathology-and-laboratory-medicine-to-low-income-and-middle-income-countries-a-call-to-action
#12
REVIEW
Susan Horton, Richard Sullivan, John Flanigan, Kenneth A Fleming, Modupe A Kuti, Lai Meng Looi, Sanjay A Pai, Mark Lawler
Modern, affordable pathology and laboratory medicine (PALM) systems are essential to achieve the 2030 Sustainable Development Goals for health in low-income and middle-income countries (LMICs). In this last in a Series of three papers about PALM in LMICs, we discuss the policy environment and emphasise three crucial high-level actions that are needed to deliver universal health coverage. First, nations need national strategic laboratory plans; second, these plans require adequate financing for implementation; and last, pathologists themselves need to take on leadership roles to advocate for the centrality of PALM to achieve the Sustainable Development Goals for health...
March 14, 2018: Lancet
https://www.readbyqxmd.com/read/29550029/access-to-pathology-and-laboratory-medicine-services-a-crucial-gap
#13
REVIEW
Michael L Wilson, Kenneth A Fleming, Modupe A Kuti, Lai Meng Looi, Nestor Lago, Kun Ru
As global efforts accelerate to implement the Sustainable Development Goals and, in particular, universal health coverage, access to high-quality and timely pathology and laboratory medicine (PALM) services will be needed to support health-care systems that are tasked with achieving these goals. This access will be most challenging to achieve in low-income and middle-income countries (LMICs), which have a disproportionately large share of the global burden of disease but a disproportionately low share of global health-care resources, particularly PALM services...
March 14, 2018: Lancet
https://www.readbyqxmd.com/read/29550027/improving-pathology-and-laboratory-medicine-in-low-income-and-middle-income-countries-roadmap-to-solutions
#14
REVIEW
Shahin Sayed, William Cherniak, Mark Lawler, Soo Yong Tan, Wafaa El Sadr, Nicholas Wolf, Shannon Silkensen, Nathan Brand, Lai Meng Looi, Sanjay A Pai, Michael L Wilson, Danny Milner, John Flanigan, Kenneth A Fleming
Insufficient awareness of the centrality of pathology and laboratory medicine (PALM) to a functioning health-care system at policy and governmental level, with the resultant inadequate investment, has meant that efforts to enhance PALM in low-income and middle-income countries have been local, fragmented, and mostly unsustainable. Responding to the four major barriers in PALM service delivery that were identified in the first paper of this Series (workforce, infrastructure, education and training, and quality assurance), this second paper identifies potential solutions that can be applied in low-income and middle-income countries (LMICs)...
March 14, 2018: Lancet
https://www.readbyqxmd.com/read/29518796/seasonal-variation-in-takotsubo-syndrome-compared-with-myocardial-infarction-anzacs-qi-16
#15
Jen-Li Looi, Mildred Lee, Corina Grey, Mark Webster, Andrew To, Andrew J Kerr
BACKGROUND: The incidence of myocardial infarction (MI) is characterised by seasonal variation, with a winter peak and summer trough. Takotsubo syndrome (TS) mimics MI, but is thought to have a distinct aetiology and may exhibit a reversed pattern of seasonal variation. This study investigated the seasonal variation in the incidence of TS in comparison to MI. METHODS: Two hundred and sixty consecutive patients with TS (95% women, median age 66 years) admitted between March 2004 and December 2016 in the Auckland region of New Zealand were identified...
March 9, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29480014/a-new-graduate-medical-school-curriculum-in-psychiatry-and-addiction-medicine-reflections-on-a-decade-of-development
#16
Daniel Bonner, Paul Maguire, Björn Cartledge, Philip Keightley, Rebecca Reay, Raj Parige, Jeff Cubis, Michael Tedeschi, Peggy Craigie, Jeffrey Cl Looi
OBJECTIVES: The aim of this study is to reflect upon the rationale, design and development of the Psychiatry and Addiction Medicine curriculum at the Australian National University Medical School, Canberra, Australian Capital Territory, Australia. CONCLUSIONS: We conclude that the development of the fourth-year curriculum of a four-year graduate medical degree was a complex evolutionary process.
February 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29445778/nadph-oxidase-4-driven-cardiac-macrophage-polarization-protects-against-myocardial-infarction-induced-remodeling
#17
Heloise Mongue-Din, Ashish S Patel, Yee H Looi, David J Grieve, Narayana Anilkumar, Alexander Sirker, Xuebin Dong, Alison C Brewer, Min Zhang, Alberto Smith, Ajay M Shah
The reactive oxygen species-generating enzyme NADPH oxidase 4 (Nox4) is up-regulated in the heart after myocardial infarction (MI). Mice with cardiomyocyte-targeted Nox4 overexpression (TG) displayed increased macrophages in the heart at baseline, with skewing toward an M2 phenotype compared with wild-type controls (WT). After MI, TG mice had a higher proportion of M2 macrophages along with higher survival, decreased cardiac remodeling, and better contractile function than wild-type mice. The post-MI increase in cardiac matrix metalloproteinase-2 activity was substantially blunted in TG mice...
December 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/29434527/visualisation-of-multiple-tight-junctional-complexes-in-human-airway-epithelial-cells
#18
Alysia G Buckley, Kevin Looi, Thomas Iosifidis, Kak-Ming Ling, Erika N Sutanto, Kelly M Martinovich, Elizabeth Kicic-Starcevich, Luke W Garratt, Nicole C Shaw, Francis J Lannigan, Alexander N Larcombe, Graeme Zosky, Darryl A Knight, Paul J Rigby, Anthony Kicic, Stephen M Stick
Background: Apically located tight junctions in airway epithelium perform a fundamental role in controlling macromolecule migration through paracellular spaces. Alterations in their expression may lead to disruptions in barrier integrity, which subsequently facilitates entry of potential bacterial and other pathogens into the host. Furthermore, there is emerging evidence that the barrier integrity of the airway in certain airway inflammatory diseases may be altered. However, there is little consensus on the way this is assessed and measured and the type of cells used to achieve this...
2018: Biological Procedures Online
https://www.readbyqxmd.com/read/29422952/gender-differences-in-the-use-of-primary-prevention-icds-in-new-zealand-patients-with-heart-failure
#19
Khang-Li Looi, Karishma Sidhu, Lisa Cooper, Liane Dawson, Debbie Slipper, Andrew Gavin, Nigel Lever
Objective: Women have been under-represented in randomised clinical trials for primary prevention implantable cardioverter defibrillators (ICDs), and there are concerns about the efficacy of devices between genders. Our study aimed to investigate gender differences in the use of primary prevention ICD in patients with heart failure from the northern region of New Zealand. Methods: Patients with heart failure with systolic dysfunction who received primary prevention ICD/cardiac resynchronisation therapy-defibrillator (CRT-D) in the northern region of New Zealand from 1 January 2007 to 1 June 2015 were included...
2018: Heart Asia
https://www.readbyqxmd.com/read/29421077/tape-seagrass-enhalus-acoroides-as-a-bioindicator-of-trace-metal-contamination-in-merambong-shoal-johor-strait-malaysia
#20
Nordiani Sidi, Ahmad Zaharin Aris, Ferdaus Mohamat Yusuff, Ley Juen Looi, Nor Farhanna Mokhtar
Revealing the potential of seagrass as a bioindicator for metal pollution is important for assessing marine ecosystem health. Trace metal (111 Cd, 63 Cu, 60 Ni, 208 Pb, 66 Zn) concentrations in the various parts (root, rhizome, and blade) of tape seagrass (Enhalus acoroides) collected from Merambong shoal of Sungai Pulai estuary, Johor Strait, Malaysia were acid-extracted using a microwave digester and analysed via inductively coupled plasma-mass spectrometry (ICP-MS). The ranges of trace metal concentrations (in μgg-1 dry weight) were as follows: Cd (0...
January 2018: Marine Pollution Bulletin
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