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https://www.readbyqxmd.com/read/28107024/the-host-response-in-sepsis-patients-developing-intensive-care-unit-acquired-secondary-infections
#1
Lonneke A van Vught, Maryse A Wiewel, Arie J Hoogendijk, Jos F Frencken, Brendon P Scicluna, Peter M C Klein Klouwenberg, Aeilko H Zwinderman, Rene Lutter, Janneke Horn, Marcus J Schultz, Marc M J Bonten, Olaf L Cremer, Tom van der Poll
RATIONALE: Sepsis can be complicated by secondary infections. We explored the possibility that sepsis patients developing a secondary infection while in the Intensive Care Unit (ICU) display sustained inflammatory, vascular and procoagulant responses. OBJECTIVE: To compare systemic proinflammatory host responses in patients with sepsis who acquire a new infection with those who do not. METHODS: Consecutive sepsis patients with a length of ICU stay >48 hours were prospectively analyzed for the development of ICU-acquired infections...
January 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28106703/clinical-application-of-a-pedicled-forearm-flap-in-the-reconstruction-after-oral-cancer-resection
#2
Xiaoqiang Zhao, Youmei Zhang, Shuai Fu, Changbin Zhang, Ming Li, Yong Wu
OBJECTIVE: To investigate the clinical application of a pedicled forearm flap in the reconstruction of soft tissue defects after oral cancer resection. METHODS: A retrospective analysis was performed on 31 patients with oral cancer in the Affiliated Stomatology Hospital of Kunming Medical University. The patients underwent repair of soft tissue defects, resulting from oral cancer resection, using a pedicled forearm flap. Patients were followed up for 3 months to 3 years to observe the survival rate of the pedicled forearm flap and the recovery of the patient's appearance and oral function...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106513/long-term-follow-up-of-superior-gluteal-artery-perforator-flap-closure-of-large-myelomeningoceles
#3
Brett A Whittemore, Dale M Swift, Bradley E Weprin, Frederick J Duffy
OBJECTIVE Large myelomeningocele defects and poor surrounding tissue quality make some defects particularly difficult to close primarily. This paper describes the superior gluteal artery perforator (SGAP) flap technique for defect closure and long-term clinical outcomes. METHODS The technique for closing a myelomeningocele with an SGAP flap is described. A retrospective chart review was performed on a cohort of 11 patients who underwent closure in this manner. RESULTS Between 1999 and 2015, 271 myelomeningoceles were closed, 11 of which were SGAP flap closures...
January 20, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28106022/complicated-left-sided-infective-endocarditis-in-chronic-hemodialysis-patients-a-case-report
#4
Öykü Gülmez, Mehtap Aydın
Infective endocarditis (IE) is a serious infectious condition with high morbidity and mortality in patients with end-stage renal disease (ESRD). It has been particularly associated with recurrent bacteremia due to vascular access via lumen catheters. The most common pathogen is Staphylococcus (S.) aureus, and most affected valve is mitral valve, which frequently calcified. Two patients with ESRD who received hemodialysis treatment via tunneled catheters, aged 56 and 88 years, were admitted with fever and high troponin level...
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28105851/in-situ-hybridization-and-promoter-analysis-reveal-that-cotton-leaf-curl-multan-betasatellite-localizes-in-the-phloem
#5
O Eini, M S Rasheed, J W Randles
Begomoviruses (the family Geminiviridae) have either a monopartite or a bipartite (DNA A and DNA B) single-stranded DNA genome. DNA B contains the open reading frame for movement protein and enables some bipartite begomoviruses to invade non-phloem tissues, whereas monopartite begomoviruses are limited to the phloem. Betasatellite DNA replicates in association with some monopartite begomoviruses to produce severe symptoms and enhance replication of helper virus in some hosts. The cotton leaf curl Multan betasatellite (CLCuMuB) has been shown to substitute for the DNA B of a bipartite begomovirus by permitting systemic infection, but the tissue tropism and the role of betasatellites in releasing monopartite begomoviruses from the phloem to adjacent tissue has not been described...
January 19, 2017: Acta Virologica
https://www.readbyqxmd.com/read/28104616/sequential-colonization-of-periodontal-pathogens-in-induction-of-periodontal-disease-and-atherosclerosis-in-ldlrnull-mice
#6
Sasanka S Chukkapalli, Meena Easwaran, Mercedes F Rivera-Kweh, Irina M Velsko, Sriram Ambadapadi, Jiayin Dai, Hannu Larjava, Alexandra R Lucas, Lakshmyya Kesavalu
Periodontal disease (PD) and atherosclerotic vascular disease (ASVD) are both chronic inflammatory diseases with a polymicrobial etiology and have been epidemiologically associated. The purpose is to examine whether periodontal bacteria that infect the periodontium, can also infect vascular tissues and enhance pre-existing early aortic atherosclerotic lesions in LDLR(null) mice. Mice were orally infected with intermediate bacterial colonizer Fusobacterium nucleatum for the first 12 weeks followed by late bacterial colonizers (Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia) for the remaining 12 weeks mimicking the human oral microbiota ecological colonization...
January 18, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28100229/surveillance-of-life-long-antibiotics-a-review-of-antibiotic-prescribing-practices-in-an-australian-healthcare-network
#7
Jillian S Y Lau, Christopher Kiss, Erika Roberts, Kylie Horne, Tony M Korman, Ian Woolley
BACKGROUND: The rise of antimicrobial use in the twentieth century has significantly reduced morbidity due to infection, however it has also brought with it the rise of increasing resistance. Some patients are on prolonged, if not "life-long" course of antibiotics. The reasons for this are varied, and include non-infectious indications. We aimed to study the characteristics of this potential source of antibiotic resistance, by exploring the antibiotic dispensing practices and describing the population of patients on long-term antibiotic therapy...
January 18, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28100157/characterization-of-planned-and-unplanned-30-day-readmissions-following-vascular-surgical-procedures
#8
Georges Tahhan, Alik Farber, Nishant K Shah, Brianna M Krafcik, Teviah E Sachs, Jeffrey A Kalish, Matthew R Peacock, Jeffrey J Siracuse
OBJECTIVE: Thirty-day readmission is increasingly used as a quality of care indicator. Patients undergoing vascular surgery have historically been at high risk for readmission. We analyzed hospital readmission details to identify patients at high risk for readmission in order to better understand these readmissions and improve resource utilization in this patient population. METHODS: A retrospective review and analysis of our medical center's admission and discharge data were conducted from October 2012 to March 2015...
January 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28100097/spina-bifida-and-lower-limb-amputation-in-northern-ireland-a-retrospective-study-of-demographics-and-outcome
#9
Lorraine Graham
BACKGROUND: Spina bifida is an uncommon cause for lower limb amputation. The causes and level of amputation and mobility outcome for these patients have not been reported previously. CASE DESCRIPTION: To identify the causes and level of amputation and the mobility outcome for amputee patients with spina bifida. STUDY DESIGN: Retrospective case series. METHODS: Chart review of patients identified by computer as having an amputation secondary to neurological or congenital cause...
January 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28099606/bacillary-angiomatosis-with-bone-invasion
#10
Lucia Martins Diniz, Karina Bittencourt Medeiros, Luana Gomes Landeiro, Elton Almeida Lucas
Bacillary angiomatosis is an infection determined by Bartonella henselae and B. quintana, rare and prevalent in patients with acquired immunodeficiency syndrome. We describe a case of a patient with AIDS and TCD4+ cells equal to 9/mm3, showing reddish-violet papular and nodular lesions, disseminated over the skin, most on the back of the right hand and third finger, with osteolysis of the distal phalanx observed by radiography. The findings of vascular proliferation with presence of bacilli, on the histopathological examination of the skin and bone lesions, led to the diagnosis of bacillary angiomatosis...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28099357/bilayered-negative-pressure-wound-therapy-preventing-leg-incision-morbidity-in-coronary-artery-bypass-graft-patients-a-randomized-controlled-trial
#11
Yongchao Yu, Zhigang Song, Zhiyun Xu, Xiaofei Ye, Chunyu Xue, Junhui Li, Hongda Bi
BACKGROUNDS: The harvesting of great saphenous veins for coronary artery bypass graft (CABG) patients may result in significant complications, including lymphorrhagia, lymphoedema, incision infection, wound dehiscence, and skin flap necrosis. We investigated the function of a self-designed bilayered negative pressure wound therapy (b-NPWT) for reducing the above-mentioned complications using a clinical randomized controlled trial. METHODS: A single-center, pilot randomized controlled trial was conducted...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28098529/multidrug-resistant-candida-haemulonii-and-c-auris-tel-aviv-israel
#12
Ronen Ben-Ami, Judith Berman, Ana Novikov, Edna Bash, Yael Shachor-Meyouhas, Shiri Zakin, Yasmin Maor, Jalal Tarabia, Vered Schechner, Amos Adler, Talya Finn
Candida auris and C. haemulonii are closely related, multidrug-resistant emerging fungal pathogens that are not readily distinguishable with phenotypic assays. We studied C. auris and C. haemulonii clinical isolates from 2 hospitals in central Israel. C. auris was isolated in 5 patients with nosocomial bloodstream infection, and C. haemulonii was found as a colonizer of leg wounds at a peripheral vascular disease clinic. Liberal use of topical miconazole and close contact among patients were implicated in C...
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28098065/the-treatment-of-post-thrombotic-syndrome
#13
Karina Schleimer, Mohammad Esmaeil Barbati, Alexander Gombert, Volker Wienert, Jochen Grommes, Houman Jalaie
BACKGROUND: Post-thrombotic syndrome (PTS) arises in 20-50% of patients who have sustained a deep vein thrombosis and markedly impairs their quality of life. METHODS: This review is based on pertinent publications retrieved by a selective literature search in PubMed and the Cochrane Library, and on the guidelines of the German Societies of Phlebology and Vascular Surgery (Deutsche Gesellschaft für Phlebologie, Deutsche Gesellschaft für Gefässchirurgie). RESULTS: The treatment options are conservative treatment with compression and patient exercises, endovascular recanalization with stent angioplasty, and open bypass surgery of the iliac obstructions...
December 16, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28097631/force-dependent-calcium-signaling-and-its-pathway-of-human-neutrophils-on-p-selectin-in-flow
#14
Bing Huang, Yingchen Ling, Jiangguo Lin, Xin Du, Ying Fang, Jianhua Wu
P-selectin engagement of P-selectin glycoprotein ligand-1 (PSGL-1) causes circulating leukocytes to roll on and adhere to the vascular surface, and mediates intracellular calcium flux, a key but unclear event for subsequent arresting firmly at and migrating into the infection or injured tissue. Using a parallel plate flow chamber technique and intracellular calcium ion detector (Fluo-4 AM), the intracellular calcium flux of firmly adhered neutrophils on immobilized P-selectin in the absence of chemokines at various wall shear stresses was investigated here in real time by fluorescence microscopy...
January 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28095498/investigation-of-the-fusarium-virguliforme-transcriptomes-induced-during-infection-of-soybean-roots-suggests-that-enzymes-with-hydrolytic-activities-could-play-a-major-role-in-root-necrosis
#15
Binod B Sahu, Jordan L Baumbach, Prashant Singh, Subodh K Srivastava, Xiaoping Yi, Madan K Bhattacharyya
Sudden death syndrome (SDS) is caused by the fungal pathogen, Fusarium virguliforme, and is a major threat to soybean production in North America. There are two major components of this disease: (i) root necrosis and (ii) foliar SDS. Root symptoms consist of root necrosis with vascular discoloration. Foliar SDS is characterized by interveinal chlorosis and leaf necrosis, and in severe cases by flower and pod abscission. A major toxin involved in initiating foliar SDS has been identified. Nothing is known about how root necrosis develops...
2017: PloS One
https://www.readbyqxmd.com/read/28094561/the-perioperative-dental-screening-and-management-of-patients-undergoing-cardiothoracic-vascular-surgery-and-other-cardiovascular-invasive-procedures-a-systematic-review
#16
Elisabetta Cotti, Mariantonietta Arrica, Andrea Di Lenarda, Sara B Serri, Pierpaolo Bassareo, Luigi Padeletti, Giuseppe Mercuro
Background One controversial issue in the relationship between oral care and cardiovascular diseases is how and whether to manage oral infections prior to cardiovascular surgery or other cardiovascular invasive procedures. Design We designed a systematic review to assess the information available on three main questions. Is there an agreement on the need for dental evaluation and treatment before cardiovascular interventions? Are consistent clinical recommendations or protocols available? Is dental treatment prior to cardiovascular interventions effective? Methods A systematic electronic search of MEDLINE, Scopus and Web of Science was performed from the database inceptions up to 31 April 2016...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28094110/use-of-convalescent-plasma-in-ebola-virus-infection
#17
REVIEW
Olivier Garraud
The recent Ebola virus epidemics which threatened three West African countries (Dec.2014-Apr.2016) has urged global collaborative health organizations and countries to set up measures to stop the infection and to treat patients, near half of them being at risk of death. Convalescent plasma-recovered from rescued West Africans-was considered a feasible therapeutic option. Efficacy was difficult to evaluate because of numerous unknowns (especially evolution of neutralizing antibodies), prior to the cessation of active transmission...
December 30, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28094022/a-case-report-of-an-adolescent-with-cluster-headaches-following-neck-trauma-coincidence-or-trigger
#18
Agnieszka Biedroń, Marek Kaciński, Małgorzata Steczkowska, Anna Świerczyńska
Posttraumatic headaches usually have tension-type or migraine-like characteristics. A correlation between head trauma and cluster headaches (CH) has been previously reported. CH in children are rare and require thorough differential diagnosis. We present an original case of a 15-year-old boy with cluster headaches associated with allodynia probably evoked by a neck trauma. Severe headache attacks started one month after neck trauma. At the beginning clinical presentation of our patient's headaches was very misleading...
January 10, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28093838/fusaric-acid-contributes-to-virulence-of-fusarium-oxysporum-on-plant-and-mammalian-hosts
#19
Cristina López-Díaz, Vahid Rahjoo, Michael Sulyok, Veronica Ghionna, Adela Martín-Vicente, Javier Capilla, Antonio Di Pietro, Manuel S López-Berges
Fusaric acid (FA) is among the oldest identified secondary metabolites produced by Fusarium species, known for a long time to display strong phytotoxicity and moderate toxicity to animal cells; however, the cellular targets of FA as well as its function in fungal pathogenicity remain unknown. Here, we investigated the role of FA in Fusarium oxysporum, a soil-borne cross-kingdom pathogen that causes vascular wilt on more than a hundred plant species and opportunistic infections in humans. Targeted deletion of fub1, encoding a predicted orthologue of the polyketide synthase involved in FA biosynthesis in F...
January 17, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28093632/ureterocystoneostomy-in-complex-oncological-cases-with-an-uebelhoer-modified-boari-bladder-flap
#20
Jan P Radtke, Nina Korzeniewski, Johannes Huber, Celine D Alt, Sascha Pahernik, Boris A Hadaschik, Markus Hohenfellner, Dogu Teber
PURPOSE: The study aims to describe the technique and analyze the outcome of an arcuated bladder incision with building of a triangular flap, first described by Uebelhoer (UBBF), as a modification of the classical rectangular Boari bladder flap (BBF), that is often viable, but can present difficulties, such as reduced flap vascularization and mobility in pretreated patients. METHODS: Twelve consecutive patients with distal or mid ureteral leakage or stenosis, that underwent UBBF, were retrospectively analyzed...
January 16, 2017: Langenbeck's Archives of Surgery
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