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https://www.readbyqxmd.com/read/28911642/lactobacillus-pentosus-gmnl-77-inhibits-skin-lesions-in%C3%A2-imiquimod-induced-psoriasis-like-mice
#1
Yi-Hsing Chen, Chieh-Shan Wu, Ya-Husan Chao, Chi-Chen Lin, Hui-Yun Tsai, Yi-Rong Li, Yi-Zhen Chen, Wan-Hua Tsai, Yu-Kuo Chen
Psoriasis, which is regarded as a T-cell-mediated chronic inflammatory skin disease, is characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. In this study, we aimed to determine the in vivo effect of a potentially probiotic strain, Lactobacillus pentosus GMNL-77, in imiquimod-induced epidermal hyperplasia and psoriasis-like skin inflammation in BALB/c mice. Oral administration of L. pentosus GMNL-77 significantly decreased erythematous scaling lesions. Real-time polymerase chain reaction showed that treatment with L...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904687/a-case-of-reccuring-giant-condyloma-of-vulva-in-infant-without-sexual-abuse-successfully-treated-with-electrocoagulation-in-benin
#2
Fabrice Akpadjan, Hugues Adégbidi, Cossi Angelo Attinsounon, Christiane Koudoukpo, Bérénice Dégboé, Nadège Agbessi, Félix Atadokpèdé
We report here a case of giant vulval condyloma in a two-year-old infant infected by her "baby sitter" without sexual abuse. Treated by surgical excision coupled with electrocoagulation, it was noted a rapid recurrence two weeks after treatment requiring a second electrocoagulation session. More than a year later, no lesion was noted, thus demonstrating therapeutic success. The unavailability of imiquimod in our context requires a systematic use of invasive treatment regardless of the age of the patient.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28901470/tlr5-7-mediated-pi3k-activation-triggers-epithelial-mesenchymal-transition-of-ovarian-cancer-cells-through-wave3-dependent-mesothelin-or-oct4-sox2-expression
#3
Ga Bin Park, Daejin Kim
Toll-like receptor (TLR)-mediated signaling induces cell migration or invasion in several tumors and various stages of cancer. Interactions of mesothelin, a 40-kDa cell surface glycoprotein, with cancer antigen 125 (CA125) is associated with drug resistance, metastasis, and poor clinical outcome of ovarian cancer patients. In this study, we examined the role of TLR5 and TLR7 in the metastasis of ovarian cancer through the induction of mesothelin/CA125 expression and investigated its underlying mechanism. TLR5 agonist (flagellin) and TLR7 agonist (imiquimod) upregulated mesenchymal phenotypes and produced epithelial-mesenchymal transition (EMT)-related cytokines in the SKOV3 cells; however, TLR7 expressing CaOV3 cells had no response to the specific ligand, imiquimod, for enhancing its EMT processes...
September 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28894754/natural-modulators-of-endosomal-toll-like-receptor-mediated-psoriatic-skin-inflammation
#4
REVIEW
Chao-Yang Lai, Yu-Wen Su, Kuo-I Lin, Li-Chung Hsu, Tsung-Hsien Chuang
Psoriasis is a chronic inflammatory autoimmune disease that can be initiated by excessive activation of endosomal toll-like receptors (TLRs), particularly TLR7, TLR8, and TLR9. Therefore, inhibitors of endosomal TLR activation are being investigated for their ability to treat this disease. The currently approved biological drugs adalimumab, etanercept, infliximab, ustekinumab, ixekizumab, and secukizumab are antibodies against effector cytokines that participate in the initiation and development of psoriasis...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28893632/patients-experiences-with-extramammary-paget-s-disease-an-online-pilot-study-querying-a-patient-support-group
#5
Paul H Chung, Jeremy T Kampp, Bryan B Voelzke
OBJECTIVE: To illustrate the heterogeneous care delivered to patients with Extramammary Paget's Disease (EMPD), a rare and lethal malignancy with poorly described treatment methodologies, by characterizing the clinical and pathological characteristics of an international patient support group. METHODS: Institutional review board approval was obtained to develop and distribute a non-validated survey to patients from an international, online EMPD support group. The survey was developed to capture patient clinical and pathological details and was distributed between January 2017 and February 2017...
September 8, 2017: Urology
https://www.readbyqxmd.com/read/28877863/the-paget-trial-a-multicenter-observational-cohort-intervention-study-for-the-clinical-efficacy-safety-and-immunological-response-of-topical-5-imiquimod-cream-for-vulvar-paget-disease
#6
Michelle van der Linden, Kim Meeuwis, Colette van Hees, Eleonora van Dorst, Johan Bulten, Tjalling Bosse, Joanna IntHout, Dorry Boll, Brigitte Slangen, Manon van Seters, Marc van Beurden, Mariëtte van Poelgeest, Joanne de Hullu
BACKGROUND: Vulvar Paget disease is a rare skin disorder, which is most common in postmenopausal Caucasian women. They usually present with an erythematous plaque that may show fine or typical "cake icing" scaling or ulceration that may cause itching, pain, irritation, or a burning sensation. Although most cases are noninvasive, vulvar Paget disease may be invasive or associated with an underlying vulvar or distant adenocarcinoma. The histological evidence of so-called "Paget cells" with abundant pale cytoplasm in the epithelium confirms the diagnosis...
September 6, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28872561/topical-imiquimod-for-melanoma-in-situ-a-word-of-caveat
#7
Ulrike Wehkamp, Thomas Schwarz
No abstract text is available yet for this article.
August 11, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28871935/topical-imiquimod-is-an-effective-and-safe-drug-for-molluscum-contagiosum-in-children
#8
George Badavanis, Efstathia Pasmatzi, Alexandra Monastirli, Sophia Georgiou, Dionysios Tsambaos
Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. In adults, the skin lesions are predominantly located in the genital region, whereas in children they are found on the trunk, the extremities, and the face...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28870465/inhibition-of-il-17-committed-t-cells-in-a-murine-psoriasis-model-by-a-vitamin-d-analogue
#9
Nobuhiro Kusuba, Akihiko Kitoh, Teruki Dainichi, Tetsuya Honda, Atsushi Otsuka, Gyohei Egawa, Saeko Nakajima, Yoshiki Miyachi, Kenji Kabashima
BACKGROUND: A better understanding of the means by which topical vitamin D analogues exert their therapeutic effect on psoriasis is of theoretical and practical importance. OBJECTIVE: We sought to clarify whether and how the topical vitamin D analogue calcipotriol (CAL) controls the IL-17A-mediated pathogenesis of murine psoriasis-like dermatitis in vivo. METHODS: Psoriasis-like dermatitis was induced by the topical application of an imiquimod (IMQ)-containing cream on the murine ear for 4 to 6 consecutive days...
September 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28855314/il-1%C3%AE-and-il-23-promote-extrathymic-commitment-of-cd27-cd122-%C3%AE-%C3%AE-t-cells-to-%C3%AE-%C3%AE-t17-cells
#10
Andreas Muschaweckh, Franziska Petermann, Thomas Korn
γδT17 cells are a subset of γδ T cells committed to IL-17 production and are characterized by the expression of IL-23R and CCR6 and lack of CD27 expression. γδT17 cells are believed to arise within a narrow time window during prenatal thymic development. In agreement with this concept, we show in this study that adult Rag1(-/-) recipient mice of Il23r(gfp/+) (IL-23R reporter) bone marrow selectively lack IL-23R(+) γδT17 cells. Despite their absence in secondary lymphoid tissues during homeostasis, γδT17 cells emerge in bone marrow chimeric mice upon induction of skin inflammation by topical treatment with imiquimod cream (Aldara)...
August 30, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28844939/lack-of-galanin-receptor-3-alleviates-psoriasis-by-altering-vascularization-immune-cell-infiltration-and-cytokine-expression
#11
Felix Locker, Silvia Vidali, Barbara S Holub, Julia Stockinger, Susanne M Brunner, Sabine Ebner, Andreas Koller, Andrea Trost, Herbert A Reitsamer, David Schwarzenbacher, Roland Lang, Barbara Kofler
The neuropeptide galanin is distributed in the central and peripheral nervous systems and in non-neuronal peripheral organs, including the skin. Galanin acts via three G protein-coupled receptors which, except galanin receptor 1, are expressed in various skin structures. The galanin system has been associated with inflammatory processes of the skin and of several other organs. Psoriasis is an inflammatory skin disease with increased neo-vascularization, keratinocyte hyperproliferation, a pro-inflammatory cytokine milieu, and immune cell infiltration...
August 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28830649/identification-of-an-imidazopyridine-scaffold-to-generate-potent-and-selective-tyk2-inhibitors-that-demonstrate-activity-in-an-in-vivo-psoriasis-model
#12
Jun Liang, Anne Van Abbema, Mercedesz Balazs, Kathy Barrett, Leo Berezhkovsky, Wade S Blair, Christine Chang, Donnie Delarosa, Jason DeVoss, Jim Driscoll, Charles Eigenbrot, Simon Goodacre, Nico Ghilardi, Calum MacLeod, Adam Johnson, Pawan Bir Kohli, Yingjie Lai, Zhonghua Lin, Priscilla Mantik, Kapil Menghrajani, Hieu Nguyen, Ivan Peng, Amy Sambrone, Steven Shia, Jan Smith, Sue Sohn, Vickie Tsui, Mark Ultsch, Karen Williams, Lawren C Wu, Wenqian Yang, Birong Zhang, Steven Magnuson
Herein we report identification of an imidazopyridine class of potent and selective TYK2 inhibitors, exemplified by prototype 6, through constraint of the rotatable amide bond connecting the pyridine and aryl rings of compound 1. Further optimization led to generation of compound 30 that potently inhibits the TYK2 enzyme and the IL-23 pathway in cells, exhibits selectivity against cellular JAK2 activity, and has good pharmacokinetic properties. In mice, compound 30 demonstrated dose-dependent reduction of IL-17 production in a PK/PD model as well as in an imiquimod-induced psoriasis model...
September 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28829805/expression-of-il-23-th17-related-cytokines-in-basal-cell-carcinoma-and-in-the-response-to-medical-treatments
#13
Cristina Pellegrini, Augusto Orlandi, Gaetana Costanza, Alessandro Di Stefani, Antonella Piccioni, Antonella Di Cesare, Andrea Chiricozzi, Amedeo Ferlosio, Ketty Peris, Maria Concetta Fargnoli
Several immune-related markers have been implicated in basal cell carcinoma (BCC) pathogenesis. The BCC inflammatory infiltrate is dominated by Th2 cytokines, suggesting a specific state of immunosuppression. In contrast, regressing BCC are characterized by a Th1 immune response with IFN-γ promoting a tumor suppressive activity. IL-23/Th17-related cytokines, as interleukin (IL)-17, IL-23 and IL-22, play a significant role in cutaneous inflammatory diseases, but their involvement in skin carcinogenesis is controversial and is poorly investigated in BCC...
2017: PloS One
https://www.readbyqxmd.com/read/28825602/role-of-neurturin-in-spontaneous-itch-and-increased-nonpeptidergic-intraepidermal-fiber-density-in-a-mouse-model-of-psoriasis
#14
Kent Sakai, Kristen M Sanders, Marina R Youssef, Kevin M Yanushefski, Liselotte E Jensen, Gil Yosipovitch, Tasuku Akiyama
Psoriasis is often accompanied by itch, but the mechanisms behind this symptom remain elusive. Dynamic changes in epidermal innervation have been observed under chronic itch conditions. Therefore, we investigated whether epidermal innervation is altered in the imiquimod-induced psoriasis mouse model, whether blockade of neurotrophic growth factor signaling can reduce these changes, and whether this system can impact psoriatic itch. Over the 7-day time course of imiquimod treatment, the density of epidermal nonpeptidergic nerves significantly increased, whereas the density of peptidergic nerves significantly decreased...
July 17, 2017: Pain
https://www.readbyqxmd.com/read/28806642/circulating-follicular-helper-t-cells-presented-distinctively-different-responses-toward-bacterial-antigens-in-primary-biliary-cholangitis
#15
Zun-Qiang Zhou, Da-Nian Tong, Jiao Guan, Mei-Fang Li, Qi-Ming Feng, Min-Jie Zhou, Zheng-Yun Zhang
Primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease with unknown causes. The initiation of PBC is associated with bacterial infections and abnormal immune correlates, such as the presence of self-reactive anti-mitochondrial antibodies and shifted balance of T cell subsets. In particular, the CD4(+)CXCR5(+) follicular helper T (Tfh) cells are highly activated in PBC patients and are significantly associated with PBC severity, but the underlying reasons are unknown. In this study, we found that the circulating CD4(+)CXCR5(+) T cells were enriched with the interferon (IFN)-γ-secreting Th1-subtype and the interleukin (IL)-17-secreting Th17-subtype, but not the IL-4-secreting Th2 subtype...
August 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28797090/imidazoquinoxaline-anticancer-derivatives-and-imiquimod-interact-with-tubulin-characterization-of-molecular-microtubule-inhibiting-mechanisms-in-correlation-with-cytotoxicity
#16
Alexis Courbet, Nicole Bec, Caroline Constant, Christian Larroque, Martine Pugniere, Safia El Messaoudi, Zahraa Zghaib, Sonia Khier, Carine Deleuze-Masquefa, Florence Gattacceca
Displaying a strong antiproliferative activity on a wide variety of cancer cells, EAPB0203 and EAPB0503 belong to the imidazo[1,2-a]quinoxalines family of imiquimod structural analogues. EAPB0503 has been shown to inhibit tubulin polymerization. The aim of the present study is to characterize the interaction of EAPB0203 and EAPB0503 with tubulin. We combine experimental approaches at the cellular and the molecular level both in vitro and in silico in order to evaluate the interaction of EAPB0203 and EAPB0503 with tubulin...
2017: PloS One
https://www.readbyqxmd.com/read/28796885/photodynamic-therapy-is-more-effective-than-imiquimod-for-actinic-keratosis-in-organ-transplant-recipients-a-randomized-intra-individual-controlled-trial
#17
K Togsverd-Bo, C Halldin, C Sandberg, H Gonzalez, A M Wennberg, S S Sørensen, H C O Wulf, M Haedersdal
BACKGROUND: Actinic keratoses (AKs) in solid organ transplant recipients (OTRs) are difficult-to-treat pre-malignancies and comparison of topical therapies is therefore warranted. OBJECTIVES: In an intra-individual study to compare efficacy and safety of field treatment with methyl aminolevulinate photodynamic therapy (MAL-PDT) and imiquimod (IMIQ) for AKs in OTRs. MATERIALS AND METHODS: OTRs (n=35) with 572 AKs (grade I-III) in two similar areas in the face, scalp, dorsal hands or forearms were included...
August 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28777892/therapeutical-modulation-of-plasmacytoid-dendritic-cells-in-experimental-arthritis
#18
Ramzi Nehmar, Ghada Alsaleh, Benjamin Voisin, Vincent Flacher, Alexandre Mariotte, Victoria Saferding, Antonia Puchner, Birgit Niederreiter, Thierry Vandamme, Gernot Schabbauer, Philippe Kastner, Susan Chan, Peggy Kirstetter, Martin Holcmann, Christopher Mueller, Jean Sibilia, Seiamak Bahram, Stephan Blüml, Philippe Georgel
OBJECTIVES: The role of plasmacytoid dendritic cells (pDCs) and type I Interferons in rheumatoid arthritis (RA) remains controversial. To explore their contribution to RA pathogenesis, we induced experimental arthritis in various animal models of pDC depletion. We also monitored the effect of localized pDC recruitment and activation on joint inflammation and bone damage. METHODS: Experimental arthritis in mice was obtained by K/BxN serum transfer, heterologous collagen immunization (CIA) or in hTNF-transgenics...
August 4, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28777803/gm-csf-in-murine-psoriasiform-dermatitis-redundant-and-pathogenic-roles-uncovered-by-antibody-induced-neutralization-and-genetic-deficiency
#19
Tatjana Scholz, Andreas Weigert, Bernhard Brüne, Christian D Sadik, Beate Böhm, Harald Burkhardt
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic, Th17-derived cytokine thought to critically contribute to the pathogenesis of diverse autoimmune diseases, including rheumatoid arthritis and psoriasis. Treatment with monoclonal antibodies that block GM-CSF activity is associated with favorable therapeutic effects in patients with rheumatoid arthritis. We evaluated the role of GM-CSF as a potential target for therapeutic interference in psoriasis using a combined pharmacologic and genetic approach and the mouse model of imiquimod-induced psoriasiform dermatitis (IMQPD)...
2017: PloS One
https://www.readbyqxmd.com/read/28769106/lipoxin-a4-and-its-analog-suppress-inflammation-by-modulating-hmgb1-translocation-and-expression-in-psoriasis
#20
Xinxin Liu, Xin Wang, Xiaoru Duan, Devesh Poorun, Juntao Xu, Song Zhang, Lu Gan, Mengwen He, Ke Zhu, Zhangyin Ming, Feng Hu, Hongxiang Chen
Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the global population, and there is still no known possibility of a cure. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. BML-111 (5(S)-6(R)-7-trihydroxyheptanoic acid methyl ester), a lipoxin receptor agonist, has been previously confirmed to be equivalent to LXA4 in the anti-inflammatory processes. High mobility group box 1 (HMGB1) serves as an inflammatory cytokine when secreted extracellularly in psoriatic lesions and is involved in the development of psoriasis...
August 2, 2017: Scientific Reports
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