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https://www.readbyqxmd.com/read/29352387/current-perspectives-on-erythema-multiforme
#1
REVIEW
Marianne Lerch, Carlo Mainetti, Benedetta Terziroli Beretta-Piccoli, Thomas Harr
Recognition and timely adequate treatment of erythema multiforme remain a major challenge. In this review, current diagnostic guidelines, potential pitfalls, and modern/novel treatment options are summarized with the aim to help clinicians with diagnostic and therapeutic decision-making. The diagnosis of erythema multiforme, that has an acute, self-limiting course, is based on its typical clinical picture of targetoid erythematous lesions with predominant acral localization as well as histological findings...
January 19, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29349514/nb-uvb-irradiation-downregulates-keratin-17-expression-in-keratinocytes-by-inhibiting-the-erk1-2-and-stat3-signaling-pathways
#2
Yuchen Zhuang, Changxu Han, Bing Li, Liang Jin, Erle Dang, Hui Fang, Hongjiang Qiao, Gang Wang
Keratin-17 (K17) is a cytoskeletal protein produced by keratinocytes (KCs), which is overexpressed in psoriasis and may play a pivotal role in its pathogenesis. Narrow-band ultraviolet B (NB-UVB) irradiation is used as a general treatment for psoriasis, although its impact on K17 expression has yet to be determined. In this study, we aimed to investigate the effect of NB-UVB irradiation on K17 expression and its signaling pathways. After exposure to NB-UVB irradiation, immortalized human keratinocytes (HaCaT cells) were analyzed by flow cytometry, CCK-8 assays and transmission electron microscopy to examine proliferation...
January 18, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29343725/the-phosphatase-ppm1a-controls-monocyte-to-macrophage-differentiation
#3
Samuel R Smith, Kaitlyn Schaaf, Nusrah Rajabalee, Frederic Wagner, Alexandra Duverger, Olaf Kutsch, Jim Sun
Differentiation of circulating monocytes into tissue-bound or tissue-resident macrophages is a critical regulatory process affecting host defense and inflammation. However, the regulatory signaling pathways that control the differentiation of monocytes into specific and distinct functional macrophage subsets are poorly understood. Herein, we demonstrate that monocyte-to-macrophage differentiation is controlled by the Protein Phosphatase, Mg2+/Mn2+-dependent 1A (PPM1A). Genetic manipulation experiments demonstrated that overexpression of PPM1A attenuated the macrophage differentiation program, while knockdown of PPM1A expression accelerated the ability of monocytes to differentiate into macrophages...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29336101/recurrence-of-vulval-intraepithelial-neoplasia-following-treatment-with-cidofovir-or-imiquimod-results-from-a-multi-centre-randomised-phase-ii-trial-rt3vin
#4
Christopher N Hurt, Sadie E F Jones, Tracie-Ann Madden, Alison Fiander, Andrew J Nordin, Raj Naik, Ned Powell, Margherita Carucci, Amanda Tristram
OBJECTIVE: To compare the recurrence rates after complete response to topical treatment with either cidofovir or imiquimod for vulval intraepithelial neoplasia (VIN) 3. DESIGN: A prospective, open, randomised multicentre trial. SETTING: 32 general hospitals located in Wales and England. POPULATION OR SAMPLE: 180 patients were randomised consecutively between Oct 21, 2009, and Jan 11, 2013, 89 to cidofoovir (of whom 41 completely responded to treatment) and 91 to imiquimod (of whom 42 completely responded to treatment)...
January 16, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29305258/irf-2-haploinsufficiency-causes-enhanced-imiquimod-induced-psoriasis-like-skin-inflammation
#5
Makiko Kawaguchi, Tomonori Oka, Makoto Sugaya, Hiraku Suga, Takayuki Kimura, Sohshi Morimura, Hideki Fujita, Shinichi Sato
BACKGROUNDS: IFN regulatory factor (IRF)-2 is one of the potential susceptibility genes for psoriasis, but how this gene influences psoriasis pathogenesis is unclear. Topical application of imiquimod (IMQ), a TLR7 ligand, induces psoriasis-like skin lesions in mice. OBJECTIVE: The aim of this study was to investigate whether IRF-2 gene status would influence severity of skin disease in IMQ-treated mice. METHODS: Imiquimod-induced psoriasis-like skin inflammation was assessed by clinical findings, histology, and cytokine expression...
December 28, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29305257/the-expression-of-mctla-4-in-skin-lesion-inversely-correlates-with-the-severity-of-psoriasis
#6
Panpan Liu, Yijing He, Honglin Wang, Yehong Kuang, Wangqing Chen, Jie Li, Mingliang Chen, Jianglin Zhang, Juan Su, Shuang Zhao, Menglin Chen, Juan Tao, Xiang Chen, Wu Zhu
BACKGROUND: Psoriasis is a chronic inflammatory disease characterized by epidermal hyperplasia and increased T cell infiltration. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a key factor that affects T cell function and immune response. However, whether the expression of CTLA-4 affects the severity of psoriasis is still unknown. OBJECTIVE: The aim of the project was to investigate the correlation between the expression of CTLA-4 and the severity of psoriasis. METHODS: The plasma soluble CTLA-4 levels and membrane CTLA-4 expression were measured by enzyme-linked immunosorbent assay and immunohistochemistry analysis in mild, moderate and severe psoriasis patients, respectively...
November 22, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29291382/t-cells-dominate-the-local-immune-response-induced-by-intralesional-il-2-in-combination-with-imiquimod-and-retinoid-for-in-transit-metastatic-melanoma
#7
Hiromi Ogawa, Guillaume Luxardi, Amanda Kirane, Rajan Kulkarni, Arta M Monjazeb, Michelle Y Cheng, Chelsea Ma, Emanual Maverakis
No abstract text is available yet for this article.
December 29, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29287831/systemic-inflammation-in-asocial-btbr-t-tf-j-mice-predisposes-them-to-increased-psoriatic-inflammation
#8
Ahmed Nadeem, Sheikh F Ahmad, Ahmad M El-Sherbeeny, Naif O Al-Harbi, Saleh A Bakheet, Sabry M Attia
Autistic Spectrum disorder (ASD) is a neurobehavioral disorder characterized by defects in communication skills leading to restricted sociability. ASD has immense dysregulation in immune responses which is thought to affect neuronal system and thus behavior. ASD patients and BTBR T+ tf/J (BTBR) autistic mice have increased systemic inflammation due to dysfunction in innate and adaptive immune responses. Recent studies suggest that ASD patients are associated with several co-morbid autoimmune disorders including psoriasis...
December 26, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29282454/interventions-for-nongenital-molluscum-contagiosum-in-persons-without-immune-deficiency
#9
Johannes C van der Wouden, Sander Koning, Kenneth A Katz
Clinical Question: How effective and safe are treatments for nongenital molluscum contagiosum in persons without immune deficiency? Bottom Line: Compared with placebo, imiquimod, 5%, cream was not more effective in clearing molluscum contagiosum and caused more local adverse effects, including application site reactions, in children aged 2 to 12 years; because high-quality evidence for other interventions is lacking, allowing for natural resolution of the infection remains a reasonable approach...
December 27, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29282183/techniques-for-optimizing-surgical-scars-part-2-hypertrophic-scars-and-keloids
#10
Kathryn Potter, Sailesh Konda, Vicky Zhen Ren, Apphia Lihan Wang, Aditya Srinivasan, Suneel Chilukuri
Surgical management of benign or malignant cutaneous tumors may result in noticeable scars that are of great concern to patients, regardless of sex, age, or ethnicity. Techniques to optimize surgical scars are discussed in this three-part review. Part 2 focuses on scar revision for hypertrophic and keloids scars. Scar revision options for hypertrophic and keloid scars include corticosteroids, bleomycin, fluorouracil, verapamil, avotermin, hydrogel scaffold, nonablative fractional lasers, ablative and fractional ablative lasers, pulsed dye laser (PDL), flurandrenolide tape, imiquimod, onion extract, silicone, and scar massage...
2017: Skinmed
https://www.readbyqxmd.com/read/29277731/a-real-world-community-based-cohort-study-comparing-the-effectiveness-of-topical-fluoruracil-vs-topical-imiquimod-for-the-treatment-of-actinic-keratosis
#11
Romain Neugebauer, Katherine A Levandoski, Zheng Zhu, Monica Sokil, Mary-Margaret Chren, Gary D Friedman, Maryam M Asgari
BACKGROUND: The most widely used topical agents for the field-based treatment of multiple actinic keratoses (AKs) are 5-fluorouracil and imiquimod, but their comparative effectiveness has not been assessed in a real-world setting. OBJECTIVE: We compared the effectiveness of 5-fluorouracil and imiquimod in reducing risk of subsequent AKs in a large, integrated healthcare delivery system in Northern California. METHODS: In this cohort study, we identified adult health plan members that had an AK diagnosed in 2007 and subsequently filled a prescription for 5-fluorouracil or imiquimod (n=5,700)...
December 22, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29277296/successful-treatment-of-giant-invasive-cutaneous-squamous-cell-carcinoma-by-plum-blossom-needle-assisted-photodynamic-therapy-sequential-with-imiquimod-case-experience
#12
Peiru Wang, Linglin Zhang, Guolong Zhang, Zhongxia Zhou, Haiyan Zhang, Zijun Zhao, Lei Shi Xiuli Wang
Giant cutaneous squamous cell carcinoma (cSCC) in elderly people is difficult to treat. Herein, we report a case of 96-year-old male who was diagnosed to have giant facial invasive SCC (4cm*4.5cm*2 cm). He was successfully treated with plum-blossom needle assisted photodynamic therapy (PDT) sequential with imiquimod. The patient achieved complete remission after 9 sessions of PDT and 3 months of imiquimod but developed residual vitiligo-like hypopigmentation. There was no recurrence at 18 months of follow-up...
December 19, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29248149/morphea-in-childhood-an-update
#13
B Aranegui, J Jiménez-Reyes
Morphea is an inflammatory, fibrosing skin disorder. When it occurs in childhood, it is also known as localized juvenile scleroderma. It is more common in girls and typically appears around the age of 5 to 7 years. According to a recent classification system, morphea is divided into 5 types: circumscribed (plaque), linear, generalized, pansclerotic, and mixed. Approximately 40% of patients present extracutaneous manifestations. Childhood morphea is treated with phototherapy, oral or topical calcitriol, topical tacrolimus 0...
December 13, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29247486/high-fat-diet-exacerbates-imiquimod-induced-psoriasis-like-dermatitis-in-mice
#14
Yuko Higashi, Munekazu Yamakuchi, Tomoko Fukushige, Atsuko Ibusuki, Teruto Hashiguchi, Takuro Kanekura
Psoriasis, a chronic inflammatory skin disease, is closely related to systemic metabolism. An elevated body mass index (BMI) is a risk factor for psoriasis; inflammasomes are activated by adipose tissue macrophages in obese subjects. We hypothesized that hyperlipidemia is involved in the pathogenesis of psoriasis and examined the role of a high fat diet (HFD) in the development of psoriasis in imiquimod (IMQ)-treated mice. The body weight and serum level of cholesterol were significantly higher in mice fed an HFD than a regular diet (RD)...
December 16, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29246367/a-12-day-course-of-imiquimod-5-for-the-treatment-of-actinic-keratosis-effectiveness-and-local-reactions
#15
C Serra-Guillén, E Nagore, B Llombart, O Sanmartín, C Requena, L Calomarde, C Guillén
INTRODUCTION AND OBJECTIVES: Imiquimod is an excellent option for patients with actinic keratosis, although its use may be limited by the long course of treatment required (4 weeks) and the likelihood of local skin reactions. The objectives of the present study were to demonstrate the effectiveness of a 12-day course of imiquimod 5% for the treatment of actinic keratosis and to examine the association between treatment effectiveness and severity of local reactions. PATIENTS AND METHODS: We included patients with at least 8 actinic keratoses treated with imiquimod 5% cream for 12 consecutive days...
December 12, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29236125/-laser-treatment-of-basal-cell-carcinoma
#16
REVIEW
C Salavastru, G S Tiplica, K Fritz
With a clear increase in the incidence and a continuously earlier onset, the main risk factors for the development of basal cell carcinoma are still exposure to sunlight, fair skin, immunosuppression, carcinogens such as arsenic, chronic irritations and certain genodermatoses. Treatment options for localized resectionable basal cell carcinoma include micrographically controlled surgery, simple excision, curettage, laser ablation, cryosurgery, imiquimod, 5‑fluorouracil, photodynamic treatment and radiotherapy...
December 13, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29225340/genetic-and-experimental-evidence-for-the-involvement-of-the-cd6-lymphocyte-receptor-in-psoriasis
#17
Marta Consuegra-Fernández, Marc Julià, Mario Martínez-Florensa, Fernando Aranda, Cristina Català, Noelia Armiger-Borràs, María-Teresa Arias, Francisca Santiago, Antonio Guilabert, Anna Esteve, Carlos Muñoz, Carlos Ferrándiz, José-Manuel Carrascosa, Edurne Pedrosa, Jorge Romaní, Mercè Alsina, José-Manuel Mascaró-Galy, Francisco Lozano
Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders, including psoriasis. Here, we present novel evidence in mice and humans for a direct involvement of CD6 in psoriasis pathophysiology. First, an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in CD6-deficient mice, as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines, namely, interleukin-17A...
December 11, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29221652/-acyclovir-resistant-perineal-hsv-infection-revealing-chronic-lymphoid-leukaemia
#18
E A Casassa, P Nicol, R Viraben, C Gaudin, C Bulai Livideanu, C Mengelle, L Lamant, F Fortenfant, C Paul, M P Konstantinou
BACKGROUND: Chronic HSV infection is a cause of chronic perineal ulcerations. We report a case of a chronic and refractory HSV infection revealing chronic lymphoid leukaemia. PATIENTS AND METHODS: An 85-year-old woman with an 8-month history of chronic perineal ulcerations was referred to our dermatology department. She had no previous medical history of herpes infection. Skin biopsies ruled out carcinoma but were consistent with HSV infection. A local swab was positive for HSV2...
December 5, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29220875/interleukin-21-receptor-signaling-is-not-critically-required-for-imiquimod-induced-psoriasiform-dermatitis-in-mice
#19
Hee Joo Kim, Sung Hee Kim, Tae-Gyun Kim, Je Yun Park, Minseok Lee, Dae Suk Kim, Min-Geol Lee
Psoriasis is largely mediated by interleukin (IL)-23/ T helper (Th) 17 axis, and IL-21 is a pleiotropic cytokine expressed by Th17 cells. Despite previously reported possible pathogenic roles of IL-21 in human psoriasis, we found that IL-21 receptor (IL-21R) signaling was not crucial for imiquimod-induced psoriatic inflammation, using IL-21R-/- mice. The severity of imiquimod-induced psoriatic manifestation and pro-inflammatory Th17 cytokine levels, IL-17A-producing γδ T cells and CD4+ T cells, and in vitro IL-17A production by γδ T cells after IL-23 stimulation was comparable between wild-type and IL-21R-/- mice...
December 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29203034/atypical-presentation-of-herpes-simplex-virus-type-2-infection-refractory-to-treatment-with-acyclovir-in-2-hematologic-patients
#20
D Nieto Rodríguez, E Sendagorta Cudós, J M Rueda Carnero, P Herranz Pinto
Herpesvirus infections are not uncommon in hematologic patients. Our first patient, diagnosed with chronic lymphatic leukemia, presented extensive genital herpes infection refractory to treatment with acyclovir and with a partial response to foscarnet, which had to be withdrawn due to systemic adverse effects. The second patient, diagnosed with follicular Hodgkin lymphoma, presented hypertrophic herpes infection refractory to treatment with acyclovir but that responded to intralesional cidofovir and topical imiquimod...
December 1, 2017: Actas Dermo-sifiliográficas
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