Yu Zuo, Sherwin Navaz, Alex Tsodikov, Katarina Kmetova, Lyndsay Kluge, Amala Ambati, Claire K Hoy, Srilakshmi Yalavarthi, Danieli de Andrade, Maria G Tektonidou, Savino Sciascia, Vittorio Pengo, Guillermo Ruiz-Irastorza, H Michael Belmont, Maria Gerosa, Paul R Fortin, Guilherme Ramires de Jesus, D Ware Branch, Laura Andreoli, Esther Rodriguez-Almaraz, Michelle Petri, Ricard Cervera, Rohan Willis, David R Karp, Quan-Zhen Li, Hannah Cohen, Maria Laura Bertolaccini, Doruk Erkan, Jason S Knight
OBJECTIVE: Our study aimed to elucidate the presence, antigen specificities, and potential clinical association of anti-neutrophil extracellular trap (anti-NET) antibodies in a multinational cohort of antiphospholipid antibody (aPL)-positive patients who did not have lupus. METHODS: Anti-NET IgG/IgM were measured in sera of 389 aPL-positive patients; 308 met the classification criteria for APS. Multivariate logistic regression with best variable model selection was used to determine clinical associations...
March 2, 2023: Arthritis & Rheumatology