keyword
MENU ▼
Read by QxMD icon Read
search

Neonate and shock

keyword
https://www.readbyqxmd.com/read/29776940/successful-treatment-of-fulminant-neonatal-enteroviral-myocarditis-in-monochorionic-diamniotic-twins-with-cardiopulmonary-support-intravenous-immunoglobulin-and-pocapavir
#1
Shahnawaz M Amdani, Hannah S Kim, Anthony Orvedahl, Audrey Odom John, Ahmed Said, Kathleen Simpson
Neonatal cardiogenic shock most commonly occurs due to critical congenital heart disease, sepsis, metabolic disorder or arrhythmias. In particular, enterovirus infections are common in the neonatal period, and patients can present with fulminant myocarditis. Early recognition is imperative due to its high morbidity and mortality without prompt and aggressive treatment. We present the successful treatment of fulminant neonatal enteroviral myocarditis in a pair of monochorionic diamniotic twins with cardiopulmonary support, intravenous immunoglobulin and pocapavir, an enteroviral capsid inhibitor...
May 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29768405/pathology-and-causes-of-death-in-stranded-humpback-whales-megaptera-novaeangliae-from-brazil
#2
Kátia Regina Groch, Josué Díaz-Delgado, Milton C C Marcondes, Adriana Castaldo Colosio, Elitieri B Santos-Neto, Vítor Luz Carvalho, Gisele Silva Boos, Ana Carolina Oliveira de Meirelles, Hernani Gomes da Cunha Ramos, Juliana Plácido Guimarães, João Carlos Gomes Borges, Jociery Einhardt Vergara-Parente, Judy A St Leger, Antonio Fernández, José Luiz Catão-Dias
This study describes the pathologic findings of 24 humpback whales (Megaptera novaeangliae) found stranded along the Brazilian coast from 2004 to 2016. Eighteen (75%) animals evaluated were found stranded alive. From these, 13 died naturally on shore and five were euthanized. Six died at sea and were washed ashore. Of the 24, 19 (79.2%) were calves, four (16.7%) were juveniles, and one (4.2%) was an adult. The most probable cause of stranding and/or death (CSD) was determined in 23/24 (95.8%) individuals. In calves, CSD included neonatal respiratory distress (13/19; 68...
2018: PloS One
https://www.readbyqxmd.com/read/29747317/-value-of-procalcitonin-in-predicting-the-severity-and-prognosis-of-neonates-with-septicemia
#3
J Zhang, D Qu, X X Ren, X D Cui, J Fu
Objective: To explore the value of procalcitonin(PCT) in predicting the severity and prognosis of neonates with septicemia. Methods: The clinical data of the hospitalized neonates over the age of 72 hours with double positive blood cultures from December 1st, 2011 to September 30, 2017 at the neonatal intensive care unit of Children's Hospital Affiliated to Capital Institute of Pediatrics was analyzed retrospectively. Results: A total of 75 neonates were included in the study. There was a significant negative correlation between PCT and neonatal critical illness score ( r =-0...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29707695/serum-heat-shock-protein-70-in-preeclampsia-and-normal-pregnancy-a-systematic-review-and-meta-analysis
#4
REVIEW
Nafiseh Saghafi, Leila Pourali, Vahid Ghavami Ghanbarabadi, Fatemeh Mirzamarjani, Masoumeh Mirteimouri
Background: Preeclampsia, a severe complication of human pregnancy is one of the main causes of maternal, fetal, and neonatal morbidity and mortality with unclear pathogenesis. Heat shock protein 70 (HSP70) is one of the factors that can mediate cytoprotective, antiapoptotic, and immune regulatory effects. Objective: This meta-analysis was performed with aim to evaluate HSP70 in preeclampsia and normal pregnancy. Materials and Methods: The original publications reporting the serum HSP70 levels in preeclampsia and normal pregnancies published before November 2015 were identified by searching PubMed Central, Scopus, and ISI Web of Knowledge databases by two researchers, separately...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29707527/treating-hypotension-in-preterm-neonates-with-vasoactive-medications
#5
REVIEW
Chloe Joynt, Po-Yin Cheung
Preterm neonates often have hypotension which may be due to various etiologies. While it is controversial to define hypotension in preterm neonates, various vasoactive medications are commonly used to provide the cardiovascular support to improve the blood pressure, cardiac output, or to treat shock. However, the literature on the systemic and regional hemodynamic effects of these antihypotensive medications in neonates is deficient and incomplete, and cautious translation of findings from other clinical populations and animal studies is required...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29699503/comparison-of-the-incidence-clinical-features-and-outcomes-of-invasive-candidiasis-in-children-and-neonates
#6
Jen-Fu Hsu, Mei-Yin Lai, Chiang-Wen Lee, Shih-Ming Chu, I-Hsyuan Wu, Hsuan-Rong Huang, I-Ta Lee, Ming-Chou Chiang, Ren-Huei Fu, Ming-Horng Tsai
BACKGROUND: Invasive candidiasis differs greatly between children and neonates. We aimed to investigate the different therapeutic approaches and their effects on treatment outcomes of these two groups. METHODS: Episodes of neonatal invasive candidiasis were compared with non-neonatal pediatric episodes during a 12-year cohort study. Clinical isolates were documented by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and DNA sequencing, and antifungal susceptibility testing was performed...
April 24, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29691444/adaptive-response-of-neonatal-sepsis-derived-group-b-streptococcus-to-bilirubin
#7
Richard Hansen, Sophie Gibson, Eduardo De Paiva Alves, Mark Goddard, Andrew MacLaren, Anne Marie Karcher, Susan Berry, Elaina S R Collie-Duguid, Emad El-Omar, Mike Munro, Georgina L Hold
Hyperbilirubinemia is so common in newborns as to be termed physiological. The most common bacteria involved in early-onset neonatal sepsis are Streptococcus agalactiae, commonly called Group B Streptococcus (GBS). Whilst previous studies show bilirubin has antioxidant properties and is beneficial in endotoxic shock, little thought has been given to whether bilirubin might have antibacterial properties. In this study, we performed a transcriptomic and proteomic assessment of GBS cultured in the presence/absence of bilirubin...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29684189/correlation-between-perfusion-index-and-crib-score-in-sick-neonates-admitted-to-a-tertiary-center
#8
Jisha Mathew, Chandrakala Bada Shekarappa, Suman Padubidri Nanyam Rao
Objective: The study was to determine the correlation of Perfusion Index (PI) and Clinical Risk Index for Babies (CRIB) score, in assessing the severity of illness in sick neonates. Methods: This was a cross-sectional study conducted at a tertiary care Neonatal Intensive Care Unit (NICU). All eligible neonates, both term and preterm, admitted to the high-dependency unit of the NICU were included, after parental consent. Relevant details of history and examination were collected with a structured proforma...
April 18, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29682452/extending-the-phenotypic-spectrum-of-sengers-syndrome-congenital-lactic-acidosis-with-synthetic-liver-dysfunction
#9
David B Beck, Kristina Cusmano-Ozog, Nickie Andescavage, Eyby Leon
Sengers syndrome is a rare autosomal recessive mitochondrial disease characterized by lactic acidosis, hypertrophic cardiomyopathy and bilateral cataracts. We present here a case of neonatal demise, within the first day of life, who initially presented with severe lactic acidosis, with evidence of both chorioamnionitis and cardiogenic shock. Initial metabolic labs demonstrated a severe lactic acidosis prompting genetic testing which revealed a homozygous pathogenic variant for Sengers syndrome in AGK, c.979A >  T; p...
April 13, 2018: Translational Science of Rare Diseases
https://www.readbyqxmd.com/read/29657735/necrotizing-enterocolitis-associated-with-clostridium-butyricum-in-a-japanese-man
#10
Yukio Sato, Dai Kujirai, Katsura Emoto, Toshiaki Yagami, Taketo Yamada, Manabu Izumi, Masaki Ano, Kenichi Kase, Kenji Kobayashi
Case: Necrotizing enterocolitis (NEC) caused by Clostridium butyricum is common in neonates; however, a case of NEC in adults has not been previously reported. An 84-year-old Japanese man developed C. butyricum -related NEC during hospitalization for treatment of stab wounds to the left side of the neck and lower abdomen, without organ damage, and concomitant pneumonia. Outcome: The patient developed acute onset of emesis accompanied by shock during his admission; partial resection of the small intestine was carried out due to necrosis...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29649938/preoperative-physiology-imaging-and-management-of-interrupted-aortic-arch
#11
Kevin Friedman
Interrupted aortic arch (IAA) is a rare form of critical neonatal heart disease in which there is lack of continuity between the ascending aorta and the descending thoracic aorta. In the absence of prenatal diagnosis, patients with IAA present in shock when the patent ductus arteriosus closes. Diagnosis can generally be made by echocardiography, and initiation of prostaglandin E1 infusion allows for adequate lower body perfusion prior to surgical repair. Full neonatal repair can be achieved with good outcomes in most cases...
April 1, 2018: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29625344/response-of-antioxidant-enzymes-to-cd-and-pb-exposure-in-water-flea-daphnia-magna-differential-metal-and-age-specific-patterns
#12
Haeyeon Kim, Ji-Soo Kim, Pyoung-Joong Kim, Eun-Ji Won, Young-Mi Lee
To investigate oxidative stress responses to cadmium and lead, the freshwater water flea Daphnia magna was exposed to Cd and Pb for 48 h. Following treatment with sub-lethal concentrations, intracellular reactive oxygen species (ROS) levels, as well as modulation of multiple biomarker, such as superoxide dismutase (SOD) activity, glutathione (GSH) contents, glutathione S-transferase (GST) activity, antioxidant enzyme - coding genes (three GST isoforms, glutaredoxin [GRx], glutathione peroxidase [GPx], and thioredoxin [TRx]), and stress-response proteins (heat shock protein 70 [Hsp70] and Hsp90) were examined...
April 3, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29600241/a-standardized-needs-assessment-tool-to-inform-the-curriculum-development-process-for-pediatric-resuscitation-simulation-based-education-in-resource-limited-settings
#13
Nicole Shilkofski, Amanda Crichlow, Julie Rice, Leslie Cope, Ye Myint Kyaw, Thazin Mon, Sarah Kiguli, Julianna Jung
Introduction: Under five mortality rates (UFMR) remain high for children in low- and middle-income countries (LMICs) in the developing world. Education for practitioners in these environments is a key factor to improve outcomes that will address United Nations Sustainable Development Goals 3 and 10 (good health and well being and reduced inequalities). In order to appropriately contextualize a curriculum using simulation, it is necessary to first conduct a needs assessment of the target learner population...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29576768/effect-of-endotoxemia-in-suckling-rats-on-pancreatic-integrity-and-exocrine-function-in-adults-a-review-report
#14
REVIEW
Jolanta Jaworek, Barbara Tudek, Paweł Kowalczyk, Michalina Kot, Joanna Szklarczyk, Anna Leja-Szpak, Piotr Pierzchalski, Joanna Bonior, Artur Dembiński, Piotr Ceranowicz, Zygmunt Warzecha, Katarzyna Nawrot-Porąbka, Krzysztof Gil
Background . Endotoxin (LPS), the component of Gram-negative bacteria, is responsible for sepsis and neonatal mortality, but low concentrations of LPS produced tissue protection in experimental studies. The effects of LPS applied to the suckling rats on the pancreas of adult animals have not been previously explored. We present the impact of neonatal endotoxemia on the pancreatic exocrine function and on the acute pancreatitis which has been investigated in the adult animals. Endotoxemia was induced in suckling rats by intraperitoneal application of LPS from Escherichia coli or Salmonella typhi ...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29570587/invasive-gastrointestinal-mucormycosis-a-master-masquerader
#15
Shalu Gupta, Muralidharan Jayashree, Arunaloke Chakrabarti, Kushaljit S Sodhi, Ravi Prakash Kanojia, Suvradeep Mitra
We report three previously well children of post neonatal age who developed fatal form of gastrointestinal mucormycosis following systemic inflammatory response syndrome, shock and metabolic acidosis. Abdominal distension and peritonitis were secondary complications. The study highlights the importance of clinical suspicion of gastrointestinal mucormycosis when the triad of shock requiring vasoactive drugs, metabolic acidosis and abdominal distension is present.
March 22, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29568083/identification-of-highly-effective-target-genes-for-rnai-mediated-control-of-emerald-ash-borer-agrilus-planipennis
#16
Thais B Rodrigues, Jian J Duan, Subba R Palli, Lynne K Rieske
Recent study has shown that RNA interference (RNAi) is efficient in emerald ash borer (EAB), Agrilus planipennis, and that ingestion of double-stranded RNA (dsRNA) targeting specific genes causes gene silencing and mortality in neonates. Here, we report on the identification of highly effective target genes for RNAi-mediated control of EAB. We screened 13 candidate genes in neonate larvae and selected the most effective target genes for further investigation, including their effect on EAB adults and on a non-target organism, Tribolium castaneum...
March 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29566368/the-trend-of-%C3%AE-3-adrenergic-receptor-in-the-development-of-septic-myocardial-depression-a-lipopolysaccharide-induced-rat-septic-shock-model
#17
Ni Yang, Xiao-Lu Shi, Bing-Lun Zhang, Jian Rong, Tie-Ning Zhang, Wei Xu, Chun-Feng Liu
Septic shock with low cardiac output is very common in children. However, the mechanism underlying myocardial depression is unclear. The role of β3-AR in the development of myocardial depression in sepsis is unknown. In the present study, we generated an adolescent rat model of hypodynamic septic shock induced by lipopolysaccharide (LPS). Neonatal cardiomyocytes were also treated with LPS to mimic myocardial depression in sepsis, which was confirmed via an in vivo left ventricular hemodynamic study, and measurements of contractility and the Ca2+ transient in isolated adolescent and neonatal cardiomyocytes...
March 22, 2018: Cardiology
https://www.readbyqxmd.com/read/29545441/total-midgut-duplication-a-ticking-time-bomb
#18
Vikram Khanna, Kashish Khanna, Maddur Srinivas
A day-old neonate presented with bowel obstruction and an abdominal mass. Exploratory laparotomy revealed complete tubular midgut duplication from duodeno-jejunal junction up to terminal ileum which was communicating with the ileum distally. At the proximal end, another 5×5 cm duplication cyst was identified and excised. Postoperatively, complaints were relieved. During follow-up, 99m-Tc-pertechnetate-SPECT scan showed ectopic gastric mucosa in lower abdomen and in the right hemithorax. CECT-chest showed a 3×3 cm foregut duplication cyst, but there were no respiratory symptoms...
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29531855/short-term-hypoxia-improves-early-cardiac-progenitor-cell-function-in-vitro
#19
Ivan Hernandez, Jonathan M Baio, Eric Tsay, Aida F Martinez, Tania I Fuentes, Leonard L Bailey, Nahidh W Hasaniya, Mary Kearns-Jonker
The use of cardiovascular progenitor cells (CPCs) to repair damaged myocardium has been the focus of intense research. Previous reports have shown that pretreatments, including hypoxia, improve cell function. However, the age-dependent effects of short-term hypoxia on CPCs, and the role of signaling in these effects, are unknown. Cloned neonatal and adult CPCs expressing Isl1, c-Kit, KDR, PDGFRA, and CXCR4, were preconditioned using hypoxia (1% O2 for six hours). Intracellular signaling pathway changes were modeled using Ingenuity Pathway Analysis (IPA), while qRT-PCR, flow cytometry, and immunoblotting were used to measure pathway activation...
2018: American Journal of Stem Cells
https://www.readbyqxmd.com/read/29526382/neonatal-nonpolio-enterovirus-and-parechovirus-infections
#20
REVIEW
Nada Harik, Roberta L DeBiasi
Nonpolio enteroviruses and parechoviruses are frequent causes of neonatal infection. Clinical manifestations of infection range from asymptomatic infection to mild infection without sequelae to septic shock with muiltiorgan failure. Neonates with clinically apparent infection typically have mothers and/or other contacts with recent symptoms consistent with a viral illness. Severe neonatal infection with nonpolio enterovirus or parechovirus cannot be differentiated clinically from serious bacterial infection...
April 2018: Seminars in Perinatology
keyword
keyword
34108
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"