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Tomography perfusion

Yi-Fan Zhou, Peng-Cheng Li, Jie-Hong Wu, James Andrew Haslam, Ling Mao, Yuan-Peng Xia, Quan-Wei He, Xu-Xia Wang, Hao Lei, Xiao-Li Lan, Qing Robert Miao, Zhen-Yu Yue, Ya-Nan Li, Bo Hu
Brain tissue survival and functional recovery after ischemic stroke greatly depend on cerebral vessel perfusion and functional collateral circulation in the ischemic area. Semaphorin 3E (Sema3E), one of the class 3 secreted semaphorins, has been demonstrated to be a critical regulator in embryonic and postnatal vascular formation via binding to its receptor PlexinD1. However, whether Sema3E/PlexinD1 signaling is involved in poststroke neovascularization remains unknown. To determine the contribution of Sema3E/PlexinD1 signaling to poststroke recovery, aged rats (18 months) were subjected to a transient middle cerebral artery occlusion...
June 11, 2018: Neurobiology of Aging
Marco Ertreo, Hailey Choi, David Field, Jonathan W Lischalk, Emil Cohen, George E Lynskey, Theresa Caridi, Donna Buckley, Keith Unger, Alexander Y Kim
PURPOSE: To compare the use of cone-beam computed tomography versus contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) in the calculation of liver volume and planned dose for yttrium-90 radioembolization. MATERIALS AND METHODS: The study retrospectively assessed 47 consecutive patients who underwent resin Y-90 radioembolization consecutively over a 2-year period at a single center. Volume calculation software was used to determine perfused lobar liver volumes from cone-beam CT (CBCT) images obtained during mapping angiography...
July 13, 2018: Cardiovascular and Interventional Radiology
Yandong Li, Ding Zhang, Benyuan Liu, Zhenxiao Jin, Weixun Duan, Xiuzhen Dong, Feng Fu, Shiqiang Yu, Xuetao Shi
OBJECTIVE: To explore the feasibility of using electrical impedance tomography (EIT) to provide noninvasive cerebral imaging and monitoring in total aortic arch replacement (TAAR). DESIGN: A prospective, observational study. SETTING: Department of cardiovascular surgery in a university hospital. PARTICIPANTS: Forty-two patients undergoing TAAR using hypothermic circulatory arrest and unilateral antegrade cerebral perfusion...
May 3, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Axel Neulen, Simon Meyer, Andreas Kramer, Tobias Pantel, Michael Kosterhon, Svenja Kunzelmann, Hermann Goetz, Serge C Thal
Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of large vessel vasospasm to impaired cerebral perfusion and neurological impairment in a murine model of SAH. SAH was induced in C57BL/6 mice by endovascular filament perforation. Vasospasm was analyzed with microcomputed tomography, cortical perfusion by laser SPECKLE contrast imaging, and functional impairment with a quantitative neuroscore...
July 12, 2018: Translational Stroke Research
Federico G Velez, Juan Pablo Davila, Andrea Diaz, Giulia Corradetti, David Sarraf, Stacy L Pineles
Importance: Anterior segment ischemia (ASI) is a rare but potentially serious complication of strabismus surgery. Indocyanine green angiography and fluorescein angiography have been used to reveal iris-filling defects for clinicians considering a patient's risk of ASI. However, both are limited by invasive and time-consuming nature and potential adverse effects. Recently, optic coherence tomography angiography (OCT-A) has been introduced and used to image iris vasculature in individuals without abnormalities...
July 12, 2018: JAMA Ophthalmology
G Papanastasiou, M C Williams, M R Dweck, S Mirsadraee, N Weir, A Fletcher, C Lucatelli, D Patel, E J R van Beek, D E Newby, S I K Semple
Kinetic modelling of myocardial perfusion imaging data allows the absolute quantification of myocardial blood flow (MBF) and can improve the diagnosis and clinical assessment of coronary artery disease (CAD). Positron emission tomography (PET) imaging is considered the reference standard technique for absolute quantification, whilst oxygen-15 (15 O)-water has been extensively implemented for MBF quantification. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) has also been used for MBF quantification and showed comparable diagnostic performance against (15 O)-water PET studies...
May 2018: IEEE Transactions on Radiation and Plasma Medical Sciences
Kalpana Rose, Hatem Krema, Priya Durairaj, Wantanee Dangboon, Yael Chavez, Susith I Kulasekara, Christopher Hudson
PURPOSE: To investigate retinal blood flow and oxygen saturation changes in patients diagnosed with retinopathy following plaque radiation treatment to treat choroidal melanoma. METHODS: Eight patients (mean age 55.75 years, SD 12.58 years) who have developed unilateral ischaemic radiation-related retinopathy as confirmed by wide-field fluorescein angiography were recruited for the study. The fellow eye with no other ocular or retinal pathology was used as control...
July 11, 2018: Acta Ophthalmologica
Jindian Li, Chenyu Peng, Zhide Guo, Changrong Shi, Rongqiang Zhuang, Xingfang Hong, Xiangyu Wang, Duo Xu, Pu Zhang, Deliang Zhang, Ting Liu, Xinhui Su, Xianzhong Zhang
The purpose of this study is to develop a specific CXCR4-targeting radioiodinated agent (125I/131I-pentixather) for single-photon emission computed tomography (SPECT) imaging of CXCR4 expression in myocardial infarction/reperfusion (MI/R) rat models. After SPECT/CT imaging with 125I-pentixather at 4, 12, 36 h, 3 and 7 d after MI/R, the models were validated by ex vivo autoradiography, TTC staining and immunohistochemistry, and in vivo echocardiography and classical 99mTc-MIBI perfusion imaging, respectively...
July 12, 2018: Analytical Chemistry
Charles Klassen, Chad Edward Eckert, Jordan Wong, Jacques P Guyette, Jason Harris, Suzanne Thompson, Leonard J Wudel, Harald C Ott
OBJECTIVE: A novel ex vivo model is described to advance the understanding of prolonged air leaks, one of the most common post-operative complications following thoracic resection procedures. METHODS: As an alternative to in vivo testing, an ex vivo model simulating the various physiologic environments experienced by an isolated lung during the perioperative period was designed and built. Isolated porcine lungs were perfused and ventilated during open chest and closed chest simulations, mimicking intra- and post-operative ventilation conditions...
March 26, 2018: IEEE Transactions on Bio-medical Engineering
Christina Byrne, Philip Hasbak, Andreas Kjær, Jens Jakob Thune, Lars Køber
Aims: Patients with non-ischaemic systolic heart failure often have reduced myocardial blood flow without significant coronary atherosclerosis. Likewise, patients with atrial fibrillation (AF) have reduced myocardial perfusion during AF compared with sinus rhythm. The aim of this study was to explore whether there is an additive negative effect of AF during scan on the myocardial perfusion in patients with non-ischaemic systolic heart failure. Methods and results: We included 27 young healthy controls and 114 patients with non-ischaemic systolic heart failure to a Rubidium-82 positron emission tomography/computed tomography perfusion scan (23 with AF during scan)...
July 9, 2018: European Heart Journal Cardiovascular Imaging
Julia Noschang, Marcos Duarte Guimarães, Diogo Fábio Dias Teixeira, Juliana Cristina Duarte Braga, Bruno Hochhegger, Pablo Rydz Pinheiro Santana, Edson Marchiori
The accurate diagnosis of pulmonary thromboembolism is essential to reducing the morbidity and mortality associated with the disease. The diagnosis of pulmonary thromboembolism is challenging because of the nonspecific nature of the clinical profile and the risk factors. Imaging methods provide the definitive diagnosis. Currently, the imaging method most commonly used in the evaluation of pulmonary thromboembolism is computed tomography. The recent development of dual-energy computed tomography has provided a promising tool for the evaluation of pulmonary perfusion through iodine mapping...
May 2018: Radiologia Brasileira
Jaechun Hwang, Mi Ji Lee, Jong-Won Chung, Oh Young Bang, Gyeong-Moon Kim, Chin-Sang Chung, Kwang Ho Lee
Background and purpose The status of collateral vessels has important clinical implications in acute ischemic stroke. To evaluate which components of ischemic symptoms were predictive of pretreatment collateral status, we tested the hypothesis that sub-item scores from the National Institutes of Health Stroke Scale (NIHSS) are associated with leptomeningeal collateral status in acute ischemic stroke with middle cerebral artery (MCA) occlusion. Methods This study included consecutive patients with acute M1 occlusion who underwent revascularization treatment for acute MCA infarction...
January 1, 2018: Interventional Neuroradiology
Tuna Çelik, Feyza Bilen, Fatime Nilüfer Yalçındağ, Huban Atilla
Optical coherence tomography angiography (OCTA) is a non-invasive alternative method used in the diagnosis and follow-up of acute branch retinal artery occlusion to show changes secondary to ischemia. We report a case with acute branch retinal artery occlusion. A 52-year-old man presented with a complaint of sudden-onset visual loss in the right lower quadrant of the left eye for the previous three days. Best-corrected visual acuity was 0.4 temporally. Inferonasal visual field deficit was detected with confrontation...
June 2018: Turkish Journal of Ophthalmology
Louise A E Brown, Sebastian C Onciul, David A Broadbent, Kerryanne Johnson, Graham J Fent, James R J Foley, Pankaj Garg, Pei G Chew, Kristopher Knott, Erica Dall'Armellina, Peter P Swoboda, Hui Xue, John P Greenwood, James C Moon, Peter Kellman, Sven Plein
BACKGROUND: Non-invasive assessment of myocardial ischaemia is a cornerstone of the diagnosis of coronary artery disease. Measurement of myocardial blood flow (MBF) using positron emission tomography (PET) is the current reference standard for non-invasive quantification of myocardial ischaemia. Dynamic myocardial perfusion cardiovascular magnetic resonance (CMR) offers an alternative to PET and a recently developed method with automated inline perfusion mapping has shown good correlation of MBF values between CMR and PET...
July 9, 2018: Journal of Cardiovascular Magnetic Resonance
Masahiko Obara, Masanao Naya, Noriko Oyama-Manabe, Tadao Aikawa, Yuuki Tomiyama, Tsukasa Sasaki, Yasuka Kikuchi, Osamu Manabe, Chietsugu Katoh, Nagara Tamaki, Hiroyuki Tsutsui
We have developed the method for dynamic 320-row multidetector computed tomography (MDCT)-derived quantitative coronary flow reserve (CFRCT) and hyperemic myocardial blood flow (MBFCT). We evaluated diagnostic value of CFRCT and hyperemic MBFCT for detecting obstructive coronary artery disease (CAD) in per-patient and per-vessel analysis, and their relations with the severity of CAD burden.Adenosine stressed and rest dynamic myocardial perfusion MDCT were prospectively performed in patients with known or suspected CAD...
July 2018: Medicine (Baltimore)
Aline Herlopian, Aaron F Struck, Eric Rosenthal, Brandon M Westover
Despite being first described over 50 years ago, periodic discharges continue to generate controversy as to whether they are always, sometimes, or never "ictal." Investigators and clinicians have proposed adjunctive markers to help clarify this distinction-in particular measures of perfusion and metabolism. Here, we review the growing number of neuroimaging studies using Fluorodeoxyglucose-PET, MRI diffusion, Magnetic resonance perfusion, Single Photon Emission Computed Tomography, and Magnetoencepgalography to gain further insight into the physiology and clinical significance of periodic discharges...
July 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Marie-Bénédicte Rougier, Mélanie Le Goff, Jean-François Korobelnik
Background: The differential diagnosis of optic disc edema at the acute phase can be challenging. OCT angiography (OCTA) is a new technology allowing the visualization of the peripapillary vascular network and optic disc capillaries. The peripapillary network alterations of glaucoma and chronic non-arteritic anterior ischemic optic neuropathy (NAION) were reported. However, no OCTA studies on acute optic disc edema from various causes. The aim of this project was to use OCTA to demonstrate the vascular changes the optic nerve head of various types of optic disc edema at the acute phase...
2018: Eye and Vision (London, England)
Otto M Henriksen, Mark Bitsch Vestergaard, Ulrich Lindberg, Niels Jacob Aachmann-Andersen, Kristian Lisbjerg, Søren Just Christensen, Peter Rasmussen, Niels Vidiendal Olsen, Julie L Forman, Henrik Bo Wiberg Larsson, Ian Law
Studies of the resting brain measurements of cerebral blood flow (CBF) show large interindividual and regional variability, but the metabolic basis of this variability is not fully established. The aim of the present study was to reassess regional and interindividual relationship between cerebral perfusion and glucose metabolism in the resting brain. Regional quantitative measurements of CBF and cerebral metabolic rate of glucose (CMRglc ) were obtained in 24 healthy young males using dynamic 15 O-H2 O and 18 F-fluoro-deoxyglucose positron emission tomography (PET)...
July 5, 2018: Journal of Applied Physiology
Ji Hoon Phi, Seung Jin Lee, Hyun Seung Kang, Jeong Eun Kim, Seung Ki Kim, Won Sang Cho, Seo Young Lee
BACKGROUND AND PURPOSE: Sudden neurological deterioration which cannot be explained by structural change, ischemia or seizure is often observed among neurosurgical patients. We aimed to provide new insight into the pathophysiology of postoperative transient neurologic dysfunction. METHODS: We describe prolonged but fully reversible focal neurologic dysfunction of unknown origin based on the initial evaluation in 8 patients who had received encephalo-duro-arterio-synangiosis for moyamoya disease...
July 2018: Journal of Clinical Neurology
Eiji Higashi, Takeshi Uwatoko, Taichiro Mizokami, Yusuke Sakaki, Shuji Sakata, Hiroshi Sugimori
Reversible cerebral vasoconstriction is a very rare complication after carotid artery stenting (CAS). It has been reported to occur more than several hours after CAS and to have a good clinical course. A 73-year-old man underwent CAS for a high-grade symptomatic stenosis of his left carotid artery. Immediately after CAS, he had consciousness disturbance and right hemiparesis. We first suspected hyperperfusion syndrome, but antihypertensive therapy exacerbated his symptoms. On repeated postoperative angiography, the middle cerebral artery (MCA) appeared to become progressively narrower...
January 1, 2018: Interventional Neuroradiology
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