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Osteoclastogenesis

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https://www.readbyqxmd.com/read/28807800/the-synergistic-effects-of-sr-and-si-bioactive-ions-on-osteogenesis-osteoclastogenesis-and-angiogenesis-for-osteoporotic-bone-regeneration
#1
Lixia Mao, Lunguo Xia, Jiang Chang, Jiaqiang Liu, Lingyong Jiang, Chengtie Wu, Bing Fang
Bioactive ions released from bioceramics play important roles in bone regeneration; however, it is unclear how each ionic composition in complex bioceramics exerts its specific effect on bone regeneration. The aim of this study is to elucidate the functional effects of Sr and Si ions in bioceramics on the regeneration of osteoporotic bone. A model bioceramic with Sr- and Si-containing components (SMS) was successfully fabricated and the effects of ionic products from SMS bioceramics on the osteogenic, osteoclastic and angiogenic differentiation of rBMSCs-OVX and RANKL-induced osteoclasts were investigated...
August 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28807789/the-expression-of-erk-and-jnk-in-patients-with-an-endemic-osteochondropathy-kashin-beck-disease
#2
XiaoXia Dai, RuiXia Song, YongMin Xiong
Kashin-Beck disease (KBD) is a chronic, endemic osteochondropathy. Its etiopathogenesis is still obscure until now. Epidemiological observation has shown that low selenium play a crucial role in the pathogenesis of KBD. Extracellular signal-regulated kinases (ERKs) and C-Jun N-terminal kinase (JNK), members of the mitogen-activated protein kinase (MAPK) superfamily, play an important role in cell proliferation and differentiation. Nuclear factor-ĸB (NF-ĸB), an important signaling mediator for inflammatory and immune responses, is involved in the regulation of osteoclastogenesis...
August 11, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28802000/pmepa1-induced-by-rankl-p38-mapk-pathway-has-a-novel-role-in-osteoclastogenesis
#3
Noboru Funakubo, Xianghe Xu, Toshio Kukita, Seiji Nakamura, Hiroshi Miyamoto, Akiko Kukita
Osteoclasts are multinucleated cells formed by fusion of preosteoclasts (POCs) derived from cells of the monocyte/macrophage lineage. We have reported a culture system that supports the formation of POCs from stroma-depleted rat bone marrow cells. Global gene expression analysis of this culture system identified genes highly expressed in POCs. Here, we have analyzed the expression and function of one of these highly expressed genes, prostate transmembrane protein androgen induced 1 (Pmepa1), a target of TGF-β and binds Nedd4 ubiquitin ligase, which plays a role in intracellular trafficking...
August 12, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28793923/concurrent-antitumor-and-bone-protective-effects-of-everolimus-in-osteotropic-breast-cancer
#4
Andrew J Browne, Marie L Kubasch, Andy Göbel, Peyman Hadji, David Chen, Martina Rauner, Friedrich Stölzel, Lorenz C Hofbauer, Tilman D Rachner
BACKGROUND: The mammalian target of rapamycin inhibitor everolimus is approved as an antitumor agent in advanced estrogen receptor-positive breast cancer. Surrogate bone marker data from clinical trials suggest effects on bone metabolism, but the mode of action of everolimus in bone biology remains unclear. In this study, we assessed potential bone-protective effects of everolimus in the context of osteotropic tumors. METHODS: The effects of everolimus on cancer cell viability in vitro and on tumor growth in vivo were assessed...
August 9, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28783657/plasmodium-products-persist-in-the-bone-marrow-and-promote-chronic-bone-loss
#5
Michelle S J Lee, Kenta Maruyama, Yukiko Fujita, Aki Konishi, Patrick M Lelliott, Sawako Itagaki, Toshihiro Horii, Jing-Wen Lin, Shahid M Khan, Etsushi Kuroda, Shizuo Akira, Ken J Ishii, Cevayir Coban
Although malaria is a life-threatening disease with severe complications, most people develop partial immunity and suffer from mild symptoms. However, incomplete recovery from infection causes chronic illness, and little is known of the potential outcomes of this chronicity. We found that malaria causes bone loss and growth retardation as a result of chronic bone inflammation induced by Plasmodium products. Acute malaria infection severely suppresses bone homeostasis, but sustained accumulation of Plasmodium products in the bone marrow niche induces MyD88-dependent inflammatory responses in osteoclast and osteoblast precursors, leading to increased RANKL expression and overstimulation of osteoclastogenesis, favoring bone resorption...
June 2, 2017: Science Immunology
https://www.readbyqxmd.com/read/28777474/mast-cells-are-critical-regulators-of-bone-fracture-induced-inflammation-and-osteoclast-formation-and-activity
#6
Jochen Kroner, Anna Kovtun, Julia Kemmler, Joanna J Messmann, Gudrun Strauss, Sebastian Seitz, Thorsten Schinke, Michael Amling, Johanna Kotrba, Jan Dudeck, Anne Dudeck, Anita Ignatius
Mast cells, important sensor and effector cells of the immune system, may influence bone metabolism as their number is increased in osteoporotic patients. They are also present during bone fracture healing with currently unknown functions. Using a novel c-Kit-independent mouse model of mast cell deficiency, we demonstrated that mast cells did not affect physiological bone turnover. However, they triggered local and systemic inflammation after fracture by inducing release of inflammatory mediators and the recruitment of innate immune cells...
August 4, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28774817/euphorbia-factor-l1-inhibits-osteoclastogenesis-by-regulating-cellular-redox-status-and-induces-fas-mediated-apoptosis-in-osteoclast
#7
Seong-Eun Hong, Jiae Lee, Dong-Hyun Seo, Hye In Lee, Doo Ri Park, Gong-Rak Lee, You-Jin Jo, Narae Kim, Minjung Kwon, Hansem Shon, Eun Kyoung Seo, Han-Sung Kim, Soo Young Lee, Woojin Jeong
Excessive bone resorption caused by increased osteoclast number or activity leads to a variety of bone diseases including osteoporosis, rheumatoid arthritis and periodontitis. Thus, the therapeutic strategy for these diseases has been focused primarily on the inhibition of osteoclast formation and function. This study shows that euphorbia factor L1 (EFL1), a diterpenoid isolated from Euphorbia lathyris, inhibited osteoclastogenesis and induced osteoclast apoptosis. EFL1 suppressed osteoclast formation and bone resorption at both initial and terminal differentiation stages...
July 31, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28771720/cyanidin-chloride-inhibits-ovariectomy-induced-osteoporosis-by-suppressing-rankl-mediated-osteoclastogenesis-and-associated-signaling-pathways
#8
Jianwen Cheng, Lin Zhou, Qian Liu, Jennifer Tickner, Zhen Tan, Xiaofeng Li, Mei Liu, Xixi Lin, Tao Wang, Nathan J Pavlos, Jinmin Zhao, Jiake Xu
Over-production and activation of osteoclasts is a common feature of osteolytic conditions such as osteoporosis, tumor-associated osteolysis, and inflammatory bone erosion. Cyanidin Chloride, a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties, but its role in osteoclastic bone resorption and osteoporosis is not well understood. In this study, we showed that Cyanidin Chloride inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression; including ctr, ctsk and trap...
August 3, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28771086/exposure-to-low-dose-x-ray-radiation-alters-bone-progenitor-cells-and-bone-microarchitecture
#9
Florence Lima, Joshua M Swift, Elisabeth S Greene, Matthew R Allen, David A Cunningham, Leslie A Braby, Susan A Bloomfield
Exposure to high-dose ionizing radiation during medical treatment exerts well-documented deleterious effects on bone health, reducing bone density and contributing to bone growth retardation in young patients and spontaneous fracture in postmenopausal women. However, the majority of human radiation exposures occur in a much lower dose range than that used in the radiation oncology clinic. Furthermore, very few studies have examined the effects of low-dose ionizing radiation on bone integrity and results have been inconsistent...
August 3, 2017: Radiation Research
https://www.readbyqxmd.com/read/28765041/evidence-for-altered-osteoclastogenesis-in-splenocyte-cultures-from-vdr-knockout-mice
#10
Daniel C Reinke, Yolandi Starczak, Masakazu Kogawa, Kate R Barratt, Howard A Morris, Paul H Anderson, Gerald J Atkins
The indirect action of 1α,25(OH)2-vitamin-D3 (1,25D) on the osteoclast through stromal signalling is well established. The role of vitamin D in osteoclasts through direct 1,25D-VDR signalling is less well known. We showed previously that local 1,25D synthesis in osteoclasts modified osteoclastogenesis and osteoclastic resorptive activity. In this study, we hypothesised that osteoclasts lacking VDR expression would display an enhanced resorptive capacity due to the loss of 1,25D signalling. Splenocytes were cultured under osteoclast-differentiating conditions from mice with global deletion of the Vdr gene (VDRKO) and this was compared with age-matched wild-type littermate controls (WT)...
July 29, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28758931/tumor-stroma-crosstalk-in-bone-tissue-the-osteoclastogenic-potential-of-a-breast-cancer-cell-line-in-a-co-culture-system-and-the-role-of-egfr-inhibition
#11
Laura Mercatali, Federico La Manna, Giacomo Miserocchi, Chiara Liverani, Alessandro De Vita, Chiara Spadazzi, Alberto Bongiovanni, Federica Recine, Dino Amadori, Martina Ghetti, Toni Ibrahim
Although bone metastases represent a major challenge in the natural history of breast cancer (BC), the complex interactions involved have hindered the development of robust in vitro models. The aim of this work is the development of a preclinical model of cancer and bone stromal cells to mimic the bone microenvironment. We studied the effects on osteoclastogenesis of BC cells and Mesenchymal stem cells (MSC) cultured alone or in combination. We also analyzed: (a) whether the blockade of the Epithelial Growth Factor Receptor (EGFR) pathway modified their influence on monocytes towards differentiation, and (b) the efficacy of bone-targeted therapy on osteoclasts...
July 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28757133/corrigendum-to-autophagy-linked-fyve-containing-protein-wdfy3-interacts-with-traf6-and-modulates-rankl-induced-osteoclastogenesis-j-autoimmun-73c-2016-73-84
#12
Dennis J Wu, Ran Gu, Ritu Sarin, Regina Zavodovskaya, Chia-Pei Chen, Blaine A Christiansen, Konstantinos S Zarbalis, Iannis E Adamopoulos
No abstract text is available yet for this article.
July 27, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28756966/bone-invasion-by-oral-squamous-cell-carcinoma-molecular-alterations-leading-to-osteoclastogenesis-a-review-of-literature
#13
REVIEW
Lauretta A A Vaassen, Ernst-Jan M Speel, Peter A W H Kessler
Oral squamous cell carcinoma (OSCC) is a growing problem globally. OSCC often arises in close anatomical relation to the jaws and may invade the bone. Bone invasion by OSCC has major implications on tumor staging, choice of treatment, outcome, and quality of life. The difference in cortical or medullary bone invasion has implications for these factors. Treatment protocols used for cortical and medullary invasion differ worldwide. By researching possible pathways a more molecular-based clinical staging and tailor-made therapy can be useful for patients with bone invasion by OSCC...
April 27, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28747793/bone-matrix-components-activate-the-nlrp3-inflammasome-and-promote-osteoclast-differentiation
#14
Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviele
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific activation of the inflammasomes, we tested the hypothesis that bone matrix components function as DAMPs for the NLRP3 inflammasome and regulate osteoclast differentiation. Indeed, bone particles cause exuberant osteoclastogenesis in the presence of RANKL, a response that correlates with NLRP3 abundance and the state of inflammasome activation...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28746278/tlr4-inactivation-in-myeloid-cells-accelerates-bone-healing-of-a-calvarial-defect-model-in-mice
#15
Dan Wang, James R Gilbert, Gwen M Taylor, Chhinder P Sodhi, David J Hackam, Joseph E Losee, Timothy R Billiar, Gregory M Cooper
BACKGROUND: Toll-like receptor 4 (TLR4) has been implicated in inflammation-induced bone destruction in various chronic bone diseases; however, its direct influence on bone healing is not well understood. The authors' previous study showed accelerated bone healing with higher osteoclastogenesis gene expression in toll-like receptor 4 knockout mice (TLR4). This study aimed to further elucidate the underlying cellular mechanisms during fracture healing by generating a myeloid cell-specific toll-like receptor 4 knockout model (Lyz-TLR4 mice)...
August 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28745432/an-ectosteric-inhibitor-of-cathepsin-k-inhibits-bone-resorption-in-ovariectomized-mice
#16
Preety Panwar, Liming Xue, Kent Søe, Kamini Srivastava, Simon Law, Jean-Marie Delaisse, Dieter Brömme
The potent cathepsin K (CatK) inhibitor, Tanshinone IIA Sulfonic Sodium (T06), was tested for its in vitro and in vivo antiresorptive activities. T06 binds in an ectosteric site of CatK remote from its active site and selectively inhibits collagen degradation with an IC50 value of 2.7±0.2 μM (CatK:T06 molar ratio of 1:5). However, it does not suppress fluorogenic peptide cleavage and gelatinolysis at a 2,500-fold molar excess. Contrary to active site-directed CatK inhibitors, such as odanacatib, T06 suppresses bone resorption in both human and mouse osteoclasts equally well (IC50 value for human and mouse osteoclasts: 237±60 nM and 245±55 nM, respectively) and its antiresorptive activity is fully reversible in both cell types...
July 26, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28742795/cancer-associated-fibroblasts-promote-bone-invasion-in-oral-squamous-cell-carcinoma
#17
A A Elmusrati, A E Pilborough, S A Khurram, D W Lambert
BACKGROUND: The molecular mechanisms involved in the invasion of bone by oral squamous cell carcinomas (OSCC) are poorly understood, and little is known about the role of cancer-associated fibroblasts (CAF), the presence of which confers a poor prognosis. METHODS: Clinicopathological data from 277 OSCC cases involving bone resections were reviewed, and 32 cases thoroughly analysed histologically. Immunohistochemistry was used to examine αSMA, RANKL and OPG. Western blotting and qPCR were used to assess myofibroblast (CAF-like) differentiation, RANKL and OPG expression in vitro, and RANKL secretion was analysed by ELISA...
July 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28742503/pth-and-pthr1-in-osteocytes-new-insights-into-old-partners
#18
Maria P Yavropoulou, Alexandros Michopoulos, John G Yovos
Parathyroid hormone receptors are present in bone cells and play a crucial role in the maintenance of skeletal integrity, bone homeostasis and regulation of calcium and phosphate metabolism. Although the function of these receptors has long being recognized in the cells of the osteoblastic lineage regulating directly osteoblast differentiation and function and indirectly osteoclastogenesis, recent findings demonstrate their functional presence in osteocytes participating in the co-ordination of bone remodelling...
April 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28742266/p-coumaric-acid-a-dietary-polyphenol-ameliorates-inflammation-and-curtails-cartilage-and-bone-erosion-in-the-rheumatoid-arthritis-rat-model
#19
Manoj Kumar Neog, Samuel Joshua Pragasam, Moorthy Krishnan, Mahaboobkhan Rasool
This study was designed to explore the underlying mechanism of p-coumaric acid (CA), a dietary polyphenol in adjuvant-induced arthritis (AIA) rat model with reference to synovitis and osteoclastogenesis. Celecoxib (COX-2 selective inhibitor) (5 mg/kg b.wt) was used as a reference drug. CA remarkably suppressed the paw edema, body weight loss and inflammatory cytokine and chemokine levels (TNF-α, IL-1β, IL-6, and MCP-1) in serum and ankle joint of arthritic rats. Consistently, CA reduced the expression of osteoclastogenic factors (RANKL and TRAP), pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-17), and inflammatory enzymes (iNOS and COX-2) in arthritic rats...
July 25, 2017: BioFactors
https://www.readbyqxmd.com/read/28742141/bruton-s-tyrosine-kinase-inhibitor-bms-986142-in-experimental-models-of-rheumatoid-arthritis-enhances-efficacy-of-agents-representing-clinical-standard-of-care
#20
Kathleen M Gillooly, Claudine Pulicicchio, Mark A Pattoli, Lihong Cheng, Stacey Skala, Elizabeth M Heimrich, Kim W McIntyre, Tracy L Taylor, Daniel W Kukral, Shailesh Dudhgaonkar, Jignesh Nagar, Dana Banas, Scott H Watterson, Joseph A Tino, Aberra Fura, James R Burke
Bruton's tyrosine kinase (BTK) regulates critical signal transduction pathways involved in the pathobiology of rheumatoid arthritis (RA) and other autoimmune disorders. BMS-986142 is a potent and highly selective reversible small molecule inhibitor of BTK currently being investigated in clinical trials for the treatment of both RA and primary Sjögren's syndrome. In the present report, we detail the in vitro and in vivo pharmacology of BMS-986142 and show this agent provides potent and selective inhibition of BTK (IC50 = 0...
2017: PloS One
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