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Osteoclastogenesis

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https://www.readbyqxmd.com/read/29777277/impact-of-muscle-atrophy-on-bone-metabolism-and-bone-strength-implications-for-muscle-bone-crosstalk-with-aging-and-disuse
#1
REVIEW
T Bettis, B-J Kim, M W Hamrick
Bone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to microgravity is also preceded by a rapid loss of muscle mass. Recent studies using animal models in the setting of hindlimb unloading or botulinum toxin (Botox) injection also reveal that muscle loss can induce bone loss. Moreover, muscle-derived factors such as irisin and leptin can inhibit bone loss with unloading, and knockout of catabolic factors in muscle such as the ubiquitin ligase Murf1 or the myokine myostatin can reduce osteoclastogenesis...
May 18, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29775898/particle-induced-sirt1-downregulation-promotes-osteoclastogenesis-and-osteolysis-through-er-stress-regulation
#2
Liang Zhang, Dongmei Bao, Peng Li, Zhidong Lu, Long Pang, Zhirong Chen, Haohui Guo, Zhihui Gao, Qunhua Jin
BACKGROUND: Sirtuin 1 (SIRT1) downregulation has been found to be induced by wear particles in aseptic prosthesis loosening (APL). Osteoclastogenesis and osteoclast activation are the main pathological factors associated with APL. However, whether SIRT1 downregulation contributes to the formation and activation of osteoclasts through the induction of endoplasmic reticulum (ER) stress is unclear. METHODS: To address this, an osteolysis mouse model was used in which animals were treated with the SIRT1 activator, resveratrol (RES), or an ER stress inhibitor, 4-PBA, for two weeks...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29773986/flavopiridol-protects-bone-tissue-by-attenuating-rankl-induced-osteoclast-formation
#3
Zi'ang Hu, Yilei Chen, Lijiang Song, Jasper H N Yik, Dominik R Haudenschild, Shunwu Fan
Bone resorption and homeostasis is carried out by osteoclasts, whose differentiation and activity are regulated by the RANK/RANKL axis. Our previous studies using a mouse model of joint injury show that joint trauma induces local inflammation followed by bone remodeling. The transcription factor cyclin-dependent kinase 9 (CDK9) is the major regulator of inflammation, as CDK9 inhibitor flavopiridol effectively suppress injury-induced inflammatory response. The objective of this study was to investigate the underlying mechanism through which flavopiridol regulates bone resorption...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29771602/irisin-promotes-proliferation-but-inhibits-differentiation-in-osteoclast-precursor-cells
#4
Yaxian Ma, Xiaoyong Qiao, Rujun Zeng, Ran Cheng, Jun Zhang, Yunyao Luo, Ying Nie, Ying Hu, Zhilan Yang, Jing Zhang, Lin Liu, Wenming Xu, Charles C Xu, Liangzhi Xu
The receptor activator of NF-κB ligand-induced osteoclast differentiation has a critical role in the process of bone metabolism. Overactivation of osteoclastogenesis may result in a series of diseases. Irisin, a novel myokine, which was first reported in 2012, has been proposed to mediate the beneficial metabolic effects of exercise. Studies have demonstrated that irisin targets osteoblasts by promoting osteoblast proliferation and differentiation; however, the underlying mechanism regarding the effect of irisin on osteoclasts remains elusive...
May 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29764006/tectorigenin-promotes-osteoblast-differentiation-and-in-vivo-bone-healing-but-suppresses-osteoclast-differentiation-and-in-vivo-bone-resorption
#5
So-Youn Lee, Gyu-Tae Kim, Hyung-Mun Yun, Youn-Chul Kim, Il-Keun Kwon, Eun-Cheol Kim
Although Tectorigenin (TG), a major compound in the rhizome of Belamcanda chinensis, is conventionally used for the treatment of inflammatory diseases, its effects on osteogenesis and osteoclastogenesis have not been reported. The objective of this study was to investigate the effects and possible underlying mechanism of TG on in vitro osteoblastic differentiation and in vivo bone formation, as well as in vitro osteoclast differentiation and in vivo bone resorption. TG promoted the osteogenic differentiation of primary osteoblasts and periodontal ligament cells...
May 15, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29761933/th1-th17-th22-immune-response-and-their-association-with-joint-pain-imagenological-bone-loss-rankl-expression-and-osteoclast-activity-in-temporomandibular-joint-osteoarthritis-a-preliminary-report
#6
Gustavo Monasterio, Francisca Castillo, Leticia Rojas, Emilio A Cafferata, Carla Alvarez, Paola Carvajal, Cristián Núñez, Guillermo Flores, Walter Díaz, Rolando Vernal
It is well accepted that the presence of cytokines belonging to the Th1/Th17/Th22 axis of immuno-inflammatory response in the joint environment, such as IL-1β, IL-17, and IL-22, respectively, are associated with pathogenesis of several synovial joint degenerative disorders. During temporomandibular joint osteoarthritis (TMJ-OA), IL-1β and IL-17 have been implicated in the inflammation and resorption of sub-chondral bone; however, the role of Th22-response in the TMJ-OA pathophysiology has not been established...
May 15, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29756076/gap-junctional-communication-is-involved-in-differentiation-of-osteoclasts-from-bone-marrow-and-peripheral-blood-monocytes
#7
Elina Kylmäoja, Miho Nakamura, Hanna Kokkonen-Puuperä, Veli-Pekka Ronkainen, Petri Lehenkari, Juha Tuukkanen
Aims: The aim of the study was to compare the influence of gap junctional communication (GJC) in osteoclastogenesis from bone marrow (BM) and peripheral blood (PB) monocytes. These widely used sources differ in purity, since BM cultures contain a significant number of stromal cells. We studied whether stimulation of GJC in BM monocyte/stromal cell cultures differs from the effect in pure PB monocyte cultures. We compared the differentiation also in acidosis, which is a known inducer of bone resorption...
May 2018: Heliyon
https://www.readbyqxmd.com/read/29753745/1-%C3%AE-25-dihydroxyvitamin-d-3-potentiates-avian-osteoclast-activation-by-increasing-the-formation-of-zipper-like-structure-via-src-rac1-signaling
#8
Dong Wang, Jian-Hong Gu, Ling-Ling Feng, Xi-Shuai Tong, Rui-Long Song, Hong-Yan Zhao, Jian-Chun Bian, Xue-Zhong Liu, Yan Yuan, Zong-Ping Liu
Avian bone metabolism diseases affect the development and production of chickens, and many of these diseases can be prevented and controlled by balanced nutrition and hormone medicine. The steroid hormone 1α,25-dihydroxyvitamin D3 plays a key role in maintaining the balance of avian bone metabolism. Clinically, 1α,25-(OH)2 D3 has been used to treat several bone diseases. Although several previous studies have investigated the effects of 1α,25-(OH)2 D3 on osteoclastogenesis, the mechanisms underpinning osteoclast (OC) activity remain largely unknown...
May 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29751129/selective-inhibition-of-src-family-kinases-by-su6656-increases-bone-mass-by-uncoupling-bone-formation-from-resorption-in-mice
#9
Cyril Thouverey, Serge Ferrari, Joseph Caverzasio
Mice deficient in the non-receptor tyrosine kinase Src exhibit high bone mass due to impaired bone resorption and increased bone formation. Although several Src family kinase inhibitors inhibit bone resorption in vivo, they display variable effects on bone formation. SU6656 is a selective Src family kinase inhibitor with weaker activity towards the non-receptor tyrosine kinase Abl and receptor tyrosine kinases which are required for appropriate osteoblast proliferation, differentiation and function. Therefore, we sought to determine whether SU6656 could increase bone mass by inhibiting bone resorption and by stimulating bone formation, and to explore its mechanisms of action...
May 8, 2018: Bone
https://www.readbyqxmd.com/read/29750835/lrp1-suppresses-bone-resorption-in-mice-by-inhibiting-the-rankl-stimulated-nf%C3%AE%C2%BAb-and-p38-pathways-during-osteoclastogenesis
#10
Di Lu, Jianshuang Li, Huadie Liu, Gabrielle E Foxa, Kevin Weaver, Jie Li, Bart O Williams, Tao Yang
Single nucleotide polymorphisms in the LRP1 gene coding sequence are associated with low bone mass, and cell culture studies suggest that LRP1 plays a role in osteoblast proliferation and osteoblast-mediated osteoclastogenesis. However, the in vivo function of LRP1 in bone homeostasis has not been explored. In this work, we studied the osteoclast-specific role of LRP1 in bone homeostasis using a Ctsk-Cre;Lrp1f/f mouse model on the C57BL/6J background. These mice had a dramatically decreased trabecular bone mass with markedly more osteoclasts, while the osteoblast activity was unaffected or slightly increased...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750395/adamts-12-protects-against-inflammatory-arthritis-through-interacting-with-and-inactivating-proinflammatory-ctgf
#11
Jian-Lu Wei, Wenyu Fu, Aubryanna Hettinghouse, Wen-Jun He, Kenneth E Lipson, Chuan-Ju Liu
OBJECTIVE: It has been reported that a disintegrin and metalloproteinase with thrombospondin motifs-12 (ADAMTS-12) is a susceptibility gene for rheumatoid arthritis (RA) development, and its level is significantly increased in RA patients. In addition, ADAMTS-12 was also reported to be required for normal inflammation. This study aims to determine the role of ADAMTS-12 and the underlying mechanisms in the pathogenesis of inflammatory arthritis. METHODS: The collagen-induced arthritis (CIA) model was established in ADAMTS-12-deficient mice and their control littermates to determine the role of ADAMTS-12 in vivo; microCT scanning was used to demonstrate the destruction of ankle joint; histological analysis illustrated synovitis, pannus formation, as well as bone and cartilage destruction; ELISA was performed to measure serum levels of inflammatory cytokines; Protein-protein interaction assays were performed to detect the interactions of ADAMTS-12 and its various deletion mutants with connective tissue growth factor (CTGF)...
May 11, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29747758/inhibitory-effect-of-cudratricusxanthone-a-on-osteoclast-differentiation-and-function
#12
Eun-Hwa Choi, Eun-Nam Kim, Gil-Saeong Jeong
BACKGROUND: Cudratricusxanthone A (CTXA) was isolated from Cudrania tricuspidata and its anti-inflammatory, hepatoprotective, and anti-proliferative activities have previously been studied in vitro. However, effects of CTXA on osteoclast differentiation have not been investigated. PURPOSE: In this study, the effect of CTXA from C. tricuspidata on in vitro osteoclastogenesis was studied. DESIGN/METHODS: CTXA was isolated from the roots of C...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29746861/lenalidomide-regulates-osteocytes-fate-and-related-osteoclastogenesis-via-il-1%C3%AE-nf-%C3%AE%C2%BAb-rankl-signaling
#13
Xinhua Qu, Jingtian Mei, Zhifeng Yu, Zanjing Zhai, Han Qiao, Kerong Dai
Osteolytic diseases are closely associated with osteocyte fate, indicating a more efficient and crucial role of osteocyte-targeting strategy in inhibiting osteoclastogenesis. Here, we investigated the effects of lenalidomide (Lena) on osteocyte fate in order to regulate osteoclastogenesis via effective cascade-controlling response. Our data revealed that lenalidomide treatment notably rescued IL-1β induced loss of osteocyte viability by inhibiting osteocyte apoptosis with decreased osteoclast-related factors, RANKL and Sclerostin, as demonstrated by the restricted osteoclast formation and reduced bone resorption...
May 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29744028/-omics-signatures-in-peripheral-monocytes-from-women-with-low-bmd-condition
#14
REVIEW
Bhavna Daswani, M Ikram Khatkhatay
Postmenopausal osteoporosis (PMO) is a result of increased bone resorption compared to formation. Osteoclasts are responsible for bone resorption, which are derived from circulating monocytes that undertake a journey from the blood to the bone for the process of osteoclastogenesis. In recent times, the use of high throughput technologies to explore monocytes from women with low versus high bone density has led to the identification of candidate molecules that may be deregulated in PMO. This review provides a list of molecules in monocytes relevant to bone density which have been identified by "omics" studies in the last decade or so...
2018: Journal of Osteoporosis
https://www.readbyqxmd.com/read/29740080/interleukin-17-enhances-bone-morphogenetic-protein-2-induced-ectopic-bone-formation
#15
M Croes, M C Kruyt, W M Groen, K M A van Dorenmalen, W J A Dhert, F C Öner, J Alblas
Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. This study investigates whether the diverse responses mediated by IL-17 in vivo also lead to enhanced BMP-2-induced bone formation. Since IL-17 is known to induce osteoclastogenesis, we studied the interactions between IL-17 and BMP-2 in ceramic scaffolds either or not carrying a coating with the bisphosphonate zoledronic acid (ZOL). Histological evaluation revealed that IL-17 alone did not induce any osteoclasts at day 10...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739381/angiopoietin-like-4-promotes-osteosarcoma-cell-proliferation-and-migration-and-stimulates-osteoclastogenesis
#16
T Zhang, A Kastrenopoulou, Q Larrouture, N A Athanasou, H J Knowles
BACKGROUND: Osteosarcoma is the most common primary bone cancer in children and young adults. It is highly aggressive and patients that present with metastasis have a poor prognosis. Angiopoietin-like 4 (ANGPTL4) drives the progression and metastasis of many solid tumours, but has not been described in osteosarcoma tissue. ANGPTL4 also enhances osteoclast activity, which is required for osteosarcoma growth in bone. We therefore investigated the expression and function of ANGPTL4 in human osteosarcoma tissue and cell lines...
May 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29737562/mechanisms-involved-in-enhancement-of-osteoclast-formation-by-activin-a
#17
Tomonari Kajita, Wataru Ariyoshi, Toshinori Okinaga, Sho Mitsugi, Kazuhiro Tominaga, Tatsuji Nishihara
Several growth factors in bone tissues are reported to be associated with osteoclastogenesis. Activin-A, a member of the transforming growth factor-β (TGF-β) family is known to be present in bone tissues and an important regulator in osteoclastogenesis with SMAD-mediated signaling being crucial for inducing osteoclast differentiation. In the present study, we examined the effect and underlying mechanisms of activin-A on osteoclast formation in vitro culture systems. Activin-A enhanced osteoclast formation in both mouse bone marrow cells and monocyte/macrophage cell line RAW 264...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29734391/vibration-paradox-in-orthodontics-anabolic-and-catabolic-effects
#18
Mani Alikhani, Sarah Alansari, Mohammad A Hamidaddin, Chinapa Sangsuwon, Bandar Alyami, Soumya N Thirumoorthy, Serafim M Oliveira, Jeanne M Nervina, Cristina C Teixeira
Vibration in the form of High Frequency Acceleration (HFA) is anabolic on the craniofacial skeleton in the absence of inflammation. Orthodontic forces trigger an inflammation-dependent catabolic cascade that is crucial for tooth movement. It is unknown what effect HFA has on alveolar bone if applied during orthodontic treatment. The objectives of this study are to examine the effect of HFA on the rate of tooth movement and alveolar bone, and determine the mechanism by which HFA affects tooth movement. Adult Sprague Dawley rats were divided to control, orthodontic force alone (OTM), and different experimental groups that received the same orthodontic forces and different HFA regimens...
2018: PloS One
https://www.readbyqxmd.com/read/29730429/lung-adenocarcinoma-cell-derived-exosomal-mir-21-facilitates-osteoclastogenesis
#19
Zhen Xu, Xingwang Liu, Huisheng Wang, Jutao Li, Lei Dai, Jun Li, Caijun Dong
Osteoclastogenesis is the rate-limiting step in tumor osteolytic metastasis. MicroRNAs play crucial roles in tumor progression and osteoclastogenesis regulation. Recent studies have demonstrated that exosomes are able to function as messengers that deliver microRNAs between cells. However, the effects of lung adenocarcinoma cell-derived exosomal miRNAs in osteoclastogenesis remain poorly understood. In this study, we found that exosomes derived from A549 cells facilitate osteoclastogenesis. As miR-21 was involved in tumorigenesis and osteoclastogenesis, we further proved the existence of miR-21 in A549 cell-derived exosomes and investigated its function...
May 3, 2018: Gene
https://www.readbyqxmd.com/read/29730290/cystathionine-gamma-lyase-h-2-s-contributes-to-osteoclastogenesis-during-bone-remodeling-induced-by-mechanical-loading
#20
Shenzheng Mo, Yongmei Hua
Hydrogen sulfide (H2 S), a gaseous signaling molecule produced by cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), influences bone remodeling in many ways. Osteoclasts play an important role in bone remodeling during tooth movement induced by mechanical loading, which increases the rate of tooth movement. Recently, we found that osteoclasts could produce H2 S. However, whether H2 S modulates bone remodeling by affecting osteoclasts remains unclear. In this study, we found that CSE-H2 S was a dominant H2 S generating system in osteoclasts, while CBS did not generate H2 S...
May 3, 2018: Biochemical and Biophysical Research Communications
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