keyword
MENU ▼
Read by QxMD icon Read
search

Osteoclastogenesis

keyword
https://www.readbyqxmd.com/read/29334613/reduced-mir-144-3p-expression-in-serum-and-bone-mediates-osteoporosis-pathogenesis-by-targeting-rank
#1
Chunqing Wang, Hanliang He, Yu Jiang, Liang Wang, Youjia Xu
Osteoblasts and osteoclasts are responsible for the formation and resorption of bone, respectively. An imbalance between these two processes results in a disease called osteoporosis, in which a decreased level of bone strength increases the risk of a bone fracture. MicroRNAs (miRNAs) are small non-coding RNA molecules of 18-25 nucleotides that have been previously shown to control bone metabolism by regulating osteoblast and osteoclast differentiation. In the present study, we detected the expression pattern of 10 miRNAs in patient serum samples, and identified six miRNAs altered expression in patients with osteoporosis relative to non-osteoporosis...
January 15, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29330445/a-novel-approach-for-correction-of-crosstalk-effects-in-pathway-analysis-and-its-application-in-osteoporosis-research
#2
Yu Zhou, Yunlong Gao, Chao Xu, Hui Shen, Qing Tian, Hong-Wen Deng
Osteoporosis is a prevalent bone metabolic disease and peripheral blood monocytes represent a major systemic cell type for bone metabolism. To identify the key dysfunctional pathways in osteoporosis, we performed pathway analyses on microarray data of monocytes from subjects with extremely high/low hip bone mineral density. We first performed a traditional pathway analysis for which different pathways were treated as independent. However, genes overlap among pathways will lead to "crosstalk" phenomenon, which may lead to false positive/negative results...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29328370/ammonium-tetrathiomolybdate-enhances-the-antitumor-effects-of-cetuximab-via-the-suppression-of-osteoclastogenesis-in-head-and-neck-squamous-carcinoma
#3
Ayaka Morisawa, Tatsuo Okui, Tsuyoshi Shimo, Soichiro Ibaragi, Yuka Okusha, Mitsuaki Ono, Thi Thu Ha Nguyen, Nur Mohammad Monsur Hassan, Akira Sasaki
Head and neck squamous cell carcinoma (HNSCC) poses a significant challenge clinically where one of the mechanisms responsible for the invasion into facial bones occurs via the activation of osteoclasts. Copper has been demonstrated to play a key role in skeletal remodeling. However, the role of copper in cancer-associated bone destruction is thus far unknown. Lysyl oxidase (LOX) is a copper-dependent enzyme that promotes osteoclastogenesis. In the present study, we investigated the effects of copper on HNSCC with bone invasion by the copper chelator, ammonium tetrathiomolybdate (TM) in vitro and in vivo...
January 10, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29327939/blockade-of-the-complement-c5a-c5ar1-axis-impairs-lung-cancer-bone-metastasis-by-cxcl16-mediated-effects
#4
Daniel Ajona, Carolina Zandueta, Leticia Corrales, Haritz Moreno, María J Pajares, Sergio Ortiz-Espinosa, Elena Martínez-Terroba, Naiara Perurena, Fernando J de Miguel, Eloisa Jantus-Lewintre, Carlos Camps, Silvestre Vicent, Jackeline Agorreta, Luis M Montuenga, Ruben Pio, Fernando Lecanda
RATIONALE: C5aR1(CD88), a receptor for complement anaphylatoxin C5a, is a potent immune mediator. Its impact on malignant growth and dissemination of NSCLC cells is poorly understood. OBJECTIVES: To investigate the contribution of the C5a/C5aR1 axis to the malignant phenotype of NSCLC cells, particularly in skeletal colonization, a preferential lung metastasis site. METHODS: Association between C5aR1 expression and clinical outcome was assessed in silico and validated by immunohistochemistry...
January 12, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29311633/traf2-in-osteotropic-breast-cancer-cells-enhances-skeletal-tumour-growth-and-promotes-osteolysis
#5
Prabha Peramuhendige, Silvia Marino, Ryan T Bishop, Daniëlle de Ridder, Asim Khogeer, Isabella Baldini, Mattia Capulli, Nadia Rucci, Aymen I Idris
NFκB plays an important role in inflammation and bone remodelling. Tumour necrosis factor receptor associated factor 2 (TRAF2), a key component of NFκB signalling, has been identified as an oncogene, but its role in the regulation of breast cancer osteolytic metastasis remains unknown. Here, we report that stable overexpression of TRAF2 in parental and osteotropic sub-clones of human MDA-MB-231 (MDA-231) breast cancer cells increased cell growth and motility in vitro, whereas TRAF2 knockdown was inhibitory...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29305867/binding-of-pick1-pdz-domain-with-calcineurin-b-regulates-osteoclast-differentiation
#6
Yuya Kamano, Jun Watanabe, Tsutomu Iida, Takeru Kondo, Hiroko Okawa, Hirofumi Yatani, Makio Saeki, Hiroshi Egusa
The calcineurin/nuclear factor of activated T cell (NFAT) signaling pathway plays a major role in osteoclast differentiation; however, the proteins that react with the calcineurin-NFAT complex in osteoclasts to regulate osteoclastogenesis remain unclear. Here, we present evidence that PICK1 also positively regulates calcineurin B in osteoclasts to activate NFAT to promote osteoclastogenesis. mRNA and protein expression of PICK1 in murine primary bone marrow macrophages (BMMs) was significantly increased during RANKL-induced osteoclast differentiation...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29304006/suppression-of-rankl-induced-osteoclastogenesis-by-the-metabolites-from-the-marine-fungus-aspergillus-flocculosus-isolated-from-a-sponge-stylissa-sp
#7
Hee Jae Shin, Byeoung-Kyu Choi, Phan Thi Hoai Trinh, Hwa-Sun Lee, Jong Soon Kang, Tran Thi Thanh Van, Hyi-Seung Lee, Jong Seok Lee, Yeon-Ju Lee, Jihoon Lee
A new α-pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (1), and four known secondary metabolites, aspertetranone D (2), cycloechinulin (3), wasabidienone E (4), and mactanamide (5), were isolated from the marine fungus Aspergillus flocculosus derived from a sponge Stylissa sp. collected in Vietnam. The structures of Compounds 1-5 were elucidated by analysis of 1D and 2D NMR spectra and MS data. All the isolated compounds were evaluated for anti-proliferation activity and their suppression effects on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation using tartate-resisant acid phosphatase (TRAP)...
January 5, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29303005/bone-targeted-methotrexate-alendronate-conjugate-inhibits-osteoclastogenesis-in-vitro-and-prevents-bone-loss-and-inflammation-of-collagen-induced-arthritis-in-vivo
#8
Zi'ang Xie, Guanxiong Liu, Pan Tang, Xuewu Sun, Shuai Chen, An Qin, Peizhi Zhu, Jianfeng Zhang, Shunwu Fan
Rheumatoid arthritis (RA), a disease that causes joint destruction and bone erosion, is related to osteoclast activity. RA is generally treated with methotrexate (MTX). In this study, a MTX-Alendronate (ALN) conjugate was synthesized and characterized. The conjugate dramatically inhibited osteoclast formation and bone resorption compared with MTX and ALN used alone or in combination. Due to the characteristics of ALN, the MTX-ALN conjugate can adhere to the exposed bone surface and enhance drug accumulation in the pathological region for targeted therapy against osteoclastogenesis...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29301320/the-effects-of-kaempferol-inhibited-autophagy-on-osteoclast-formation
#9
Chang-Ju Kim, Sang-Hun Shin, Bok-Joo Kim, Chul-Hoon Kim, Jung-Han Kim, Hae-Mi Kang, Bong-Soo Park, In-Ryoung Kim
Kaempferol, a flavonoid compound, is derived from the rhizome of Kaempferia galanga L., which is used in traditional medicine in Asia. Autophagy has pleiotropic functions that are involved in cell growth, survival, nutrient supply under starvation, defense against pathogens, and antigen presentation. There are many studies dealing with the inhibitory effects of natural flavonoids in bone resorption. However, no studies have explained the relationship between the autophagic and inhibitory processes of osteoclastogenesis by natural flavonoids...
January 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29301147/amentoflavone-inhibits-osteoclastogenesis-and-wear-debris-induced-osteolysis-via-suppressing-nf-%C3%AE%C2%BAb-and-mapks-signaling-pathways
#10
Zhen Zhang, Shuai Zhao, Xiaolei Li, Xiaoqi Zhuo, Wu Zhang, Qian Nie, Shuguang Wang, Lianqi Yan, Yu Sun
Wear debris-induced osteolysis is one of the major reasons for subsequent aseptic loosening after cementless hip arthroplasty. Increasing evidence suggests that receptor activator of nuclear factor kappa-B (NF-κB) ligand-mediated osteoclastogenesis and osteolysis are responsible for wear debris-induced aseptic loosening. In the present study, we explored the effect of amentoflavone (AMF) on inhibiting osteoclast generation and wear debris-induced osteolysis in vitro and in vivo. Twenty-four male C57BL/J6 mice were randomly divided into four groups: a sham group and groups with titanium wear debris treatment followed by intraperitoneal injection of various concentrations of AMF (0, 20, and 40 mg/kg/day)...
January 4, 2018: Planta Medica
https://www.readbyqxmd.com/read/29300279/disease-modifying-actions-of-il-6-blockade-in-a-rat-model-of-bone-cancer-pain
#11
Bethany Remeniuk, Tamara King, Devki Suktankhar, Amy Nippert, Nancy Li, Fuying Li, Kejun Cheng, Kenner C Rice, Frank Porreca
Metastasis of cancer to the skeleton represents a debilitating turning point in the lives of patients. Skeletal metastasis leads to moderate to severe ongoing pain along with bone remodeling that can result in fracture, events that dramatically diminish quality of life. IL-6 levels are elevated in metastatic breast cancer patients and are associated with a lower survival rate. We therefore determined the consequences of inhibition of IL-6 signaling using a novel small molecule antagonist, TB-2-081, on bone integrity, tumor progression, and pain in a rodent model of breast cancer...
December 26, 2017: Pain
https://www.readbyqxmd.com/read/29297549/rank-rankl-opg-expression-in-rapid-maxillary-expansion
#12
Maya Fernanda Manfrin Arnez, Larissa Soares Nogueira Ribeiro, Gabriel Dessotti Barretto, Patrícia Maria Monteiro, Edilson Ervolino, Maria Bernadete Sasso Stuani
The aim of this study was to evaluate osteoclastogenesis signaling in midpalatal suture after rapid maxillary expansion (RME) in rats. Thirty male Wistar rats were randomly assigned to two groups with 15 animals each: control (C) and RME group. RME was performed by inserting a 1.5-mm-thick circular metal ring between the maxillary incisors. The animals were euthanized at 3, 7 and 10 days after RME. qRT-PCR was used to evaluate expression of Tnfsf11 (RANKL), Tnfrsf11a (RANK) and Tnfrsf11b (OPG). Data were submitted to statistical analysis using two-way ANOVA followed by Tukey test (a=0...
May 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29296919/hypoxia-promotes-il-32-expression-in-myeloma-cells-and-high-expression-is-associated-with-poor-survival-and-bone-loss
#13
Muhammad Zahoor, Marita Westhrin, Kristin Roseth Aass, Siv Helen Moen, Kristine Misund, Katarzyna Maria Psonka-Antonczyk, Mariaserena Giliberto, Glenn Buene, Anders Sundan, Anders Waage, Anne-Marit Sponaas, Therese Standal
Multiple myeloma (MM) is a hematologic cancer characterized by expansion of malignant plasma cells in the bone marrow. Most patients develop an osteolytic bone disease, largely caused by increased osteoclastogenesis. The myeloma bone marrow is hypoxic, and hypoxia may contribute to MM disease progression, including bone loss. Here we identified interleukin-32 (IL-32) as a novel inflammatory cytokine expressed by a subset of primary MM cells and MM cell lines. We found that high IL-32 gene expression in plasma cells correlated with inferior survival in MM and that IL-32 gene expression was higher in patients with bone disease compared with those without...
December 26, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296860/tak1-inhibition-subverts-the-osteoclastogenic-action-of-trail-while-potentiating-its-antimyeloma-effects
#14
Hirofumi Tenshin, Jumpei Teramachi, Asuka Oda, Ryota Amachi, Masahiro Hiasa, Ariunzaya Bat-Erdene, Keiichiro Watanabe, Masami Iwasa, Takeshi Harada, Shiro Fujii, Kumiko Kagawa, Kimiko Sogabe, Shingen Nakamura, Hirokazu Miki, Kiyoe Kurahashi, Sumiko Yoshida, Kenichi Aihara, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) agonists induce tumor-specific apoptosis indicating that they may be an attractive therapeutic strategy against cancers, including multiple myeloma (MM). Osteoclastogenesis is highly induced in MM, which in turn enhances MM growth, thereby forming a vicious cycle between MM tumor expansion and bone destruction. However, the effects of TRAIL on MM-enhanced osteoclastogenesis remain largely unknown. Here, we show that TRAIL induced apoptosis in MM cells, but not in osteoclasts (OCs), and that it rather facilitated receptor activator of NF-κB ligand-induced osteoclastogenesis along with upregulation of cellular FLICE inhibitory protein (c-FLIP)...
November 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/29285799/biological-effects-of-melatonin-on-osteoblast-osteoclast-co-cultures-bone-and-quality-of-life-implications-of-a-role-for-mt2-melatonin-receptors-mek1-2-and-mek5-in-melatonin-mediated-osteoblastogenesis
#15
Sifat Maria, Rebekah M Samsonraj, Fahima Munmun, Jessica Glas, Maria Silvestros, Mary P Kotlarczyk, Ryan Rylands, Amel Dudakovic, Andre J van Wijnen, Larry T Enderby, Holly Lassila, Bala Dodda, Vicki L Davis, Judy Balk, Matt Burow, Bruce A Bunnell, Paula A Witt-Enderby
The Melatonin Osteoporosis Prevention Study (MOPS) demonstrated that nightly melatonin resulted in a time-dependent decrease in equilibrium ratios of serum osteoclasts and osteoblasts in perimenopausal women. This study examines mechanisms related to the ratios of osteoblasts and osteoclasts using co-culture models (transwell or layered) of human mesenchymal stem cell (MSCs) and human peripheral blood monocytes (PBMCs). Human MSCs/PBMCs co-cultures exposed to melatonin in osteogenic (OS+) medium for 21 days induced osteoblast differentiation and mineralization; however, only in layered co-cultures did melatonin inhibit osteoclastogenesis...
December 28, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29285077/identification-of-micrornas-in-human-circulating-monocytes-of-postmenopausal-osteoporotic-mexican-mestizo-women-a-pilot-study
#16
Rogelio F Jiménez-Ortega, Eric G Ramírez-Salazar, Alma Y Parra-Torres, Said A Muñoz-Montero, Claudia Rangel-Escareňo, Ivan Salido-Guadarrama, Mauricio Rodriguez-Dorantes, Manuel Quiterio, Jorge Salmerón, Rafael Velázquez-Cruz
MicroRNAs (miRNAs or miRs) are a class of short non-coding RNAs that serve an important regulatory role in living organisms. These molecules are associated with multiple biological processes and are potential biomarkers in multiple diseases. The present study aimed to further identify miRNAs that are differentially expressed in circulating monocytes (CMCs) from postmenopausal Mexican-Mestizo women. Microarray analyses of monocytes using Affymetrix miRNA 4.0 and Human Genome U133 Plus 2.0 arrays were performed in 6 normal and 6 osteoporotic women, followed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) validation...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29282319/expression-of-an-active-g%C3%AE-s-mutant-in-skeletal-stem-cells-is-sufficient-and-necessary-for-fibrous-dysplasia-initiation-and-maintenance
#17
Xuefeng Zhao, Peng Deng, Ramiro Iglesias-Bartolome, Panomwat Amornphimoltham, Dana J Steffen, Yunyun Jin, Alfredo A Molinolo, Luis Fernandez de Castro, Diana Ovejero, Quan Yuan, Qianming Chen, Xianglong Han, Ding Bai, Susan S Taylor, Yingzi Yang, Michael T Collins, J Silvio Gutkind
Fibrous dysplasia (FD) is a disease caused by postzygotic activating mutations of GNAS (R201C and R201H) that encode the α-subunit of the Gs stimulatory protein. FD is characterized by the development of areas of abnormal fibroosseous tissue in the bones, resulting in skeletal deformities, fractures, and pain. Despite the well-defined genetic alterations underlying FD, whether GNAS activation is sufficient for FD initiation and the molecular and cellular consequences of GNAS mutations remains largely unresolved, and there are no currently available targeted therapeutic options for FD...
December 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29281118/estrogen-deficiency-mediated-m2-macrophage-osteoclastogenesis-contributes-to-m1-m2-ratio-alteration-in-ovariectomized-osteoporotic-mice
#18
Ce Dou, Ning Ding, Chunrong Zhao, Tianyong Hou, Fei Kang, Zhen Cao, Chuan Liu, Yun Bai, Qijie Dai, Qinyu Ma, Fei Luo, Jianzhong Xu, Shiwu Dong
In this study, for the first time we discovered that M1/M2 ratio is increased in bone marrow of ovariectomized (OVX) osteoporotic C57BL/6 mice. Considering estrogen is the main variable, we assumed that estrogen participated in this alteration. To determine whether and how estrogen contributes to the change of M1/M2 ratio, we first isolated bone marrow macrophages (BMMs) from mice femur and stimulated the cells with lipopolysaccharide (LPS)/Interferon (IFN)-γ for M1 polarization and interleukin (IL)-4/IL-13 for M2 polarization...
December 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29280352/mg-al-and-zn-al-layered-double-hydroxides-promote-dynamic-expression-of-marker-genes-in-osteogenic-differentiation-by-modulating-mitogen-activated-protein-kinases
#19
Ha Ram Kang, Célio Junior da Costa Fernandes, Rodrigo Augusto da Silva, Vera Regina Leopoldo Constantino, Ivan Hong Jun Koh, Willian F Zambuzzi
The effect of LDH samples comprised of chloride anions intercalated between positive layers of magnesium/aluminum (Mg-Al LDH) or zinc/aluminum (Zn-Al LDH) chemical composition on pre-osteoblast performance is investigated. Non-cytotoxic concentrations of both LDHs modulated pre-osteoblast adhesion by triggering cytoskeleton rearrangement dependent on recruiting of Cofilin, which is modulated by the inhibition of the Protein Phosphatase 2A (PP2A), culminating in osteoblast differentiation with a significant increase of osteogenic marker genes...
December 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29279565/the-effects-of-marsupialization-on-bone-regeneration-adjacent-to-keratocystic-odontogenic-tumors-and-the-mechanisms-involved
#20
Xiang Hu, Yi Zhao, Qi-Wen Man, Rui-Fang Li, Bing Liu, Yi-Fang Zhao
Bone resorption in the jaws is one of the most severe complications of keratocystic odontogenic tumors (KCOTs), and can be treated by either enucleation or marsupialization. However, the effects of marsupialization on bone regeneration adjacent to KCOTs, and the mechanisms involved, are still unclear. In this study, samples of 27 KCOTs were collected (20 before marsupialization and 7 after marsupialization) to detect the expression of bone regeneration-related molecules adjacent to KCOTs by immunohistochemistry and real-time quantitative polymerase chain reaction (qPCR)...
2017: Journal of Oral Science
keyword
keyword
34087
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"