keyword
MENU ▼
Read by QxMD icon Read
search

hyperfiltration

keyword
https://www.readbyqxmd.com/read/28439668/urinary-podocalyxin-as-a-possible-novel-marker-of-intrauterine-nephrogenesis-and-extrauterine-podocyte-injury
#1
Taihei Hayashi, Shuko Tokuriki, Takashi Okuno, Genrei Ohta, Aiko Igarashi, Yusei Ohshima
BACKGROUND: The number of nephrons at birth is determined during fetal development and is modulated thereafter by postnatal podocyte injury. Hyperfiltration, caused by a reduced number of nephrons, is a risk factor for chronic kidney disease. It is therefore important to monitor the formation of nephrons. METHODS: Urine samples were collected from infants within 1-2 days of birth, with follow-up sampling for preterm infants at 37-39 weeks of corrected age. Urinary levels of podocalyxin (PCX), β2-microglobulin (β2MG), N-acetyl-ß-D-glucosaminidase (NAG), total protein (TP), microalbumin (mAlb) and creatinine were measured and the relationship between these markers evaluated...
April 25, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28423118/obesity-and-kidney-disease-hidden-consequences-of-the-epidemic
#2
EDITORIAL
C P Kovesdy, S L Furth, C Zoccali
Obesity has become a worldwide epidemic and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long-term...
April 13, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28423054/sleep-duration-and-quality-in-relation-to-chronic-kidney-disease-and-glomerular-hyperfiltration-in-healthy-men-and-women
#3
Chan-Won Kim, Yoosoo Chang, Eunju Sung, Kyung Eun Yun, Hyun-Suk Jung, Byung-Joon Ko, Min-Jung Kwon, Young Youl Hyun, Kyu-Beck Lee, Hyang Kim, Hocheol Shin, Seungho Ryu
BACKGROUND: It is unclear whether sleep duration and quality are associated with chronic kidney disease (CKD) and glomerular hyperfiltration. The aim of this study was to examine the association of sleep duration and quality with CKD and glomerular hyperfiltration in young and middle-aged adults. METHODS: We conducted a cross-sectional study of men and women who underwent a health checkup examination, including assessment of sleep duration and quality (n = 241,607)...
2017: PloS One
https://www.readbyqxmd.com/read/28413305/solitary-functioning-kidney-in-high-anorectal-malformation
#4
Kanishka Das, Srinivas Raju Rajkiran
AIM: A solitary functioning renal unit in high anorectal malformation may harbor anomalies in the upper/lower urinary tract that further compromise renal function and accelerate hyperfiltration injury. We aimed to analyze the clinical course, management, and outcome of children with a solitary renal unit and high anorectal malformation. MATERIALS AND METHODS: A cohort of solitary renal units in anorectal malformation managed between 2000 and 2015 with a defined protocol at a pediatric nephro-urology clinic are included in the study...
April 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28412033/antagonism-of-vasopressin-v2-receptor-improves-albuminuria-at-the-early-stage-of-diabetic-nephropathy-in-a-mouse-model-of-type-2-diabetes
#5
Ray El Boustany, Christopher Taveau, Catherine Chollet, Gilberto Velho, Lise Bankir, François Alhenc-Gelas, Ronan Roussel, Nadine Bouby
AIMS: Vasopressin is increased in diabetes and was shown to contribute to development of diabetic nephropathy through V2 receptor (V2R) activation in an experimental model of type 1 diabetes. The role of V2R in type 2 diabetes remains undocumented. This study addresses the issue in a mouse model of type 2 diabetes. METHODS: Male obese diabetic db/db mice were treated for 12weeks with a selective V2R antagonist (SR121463) and compared to non-treated db/db and non-diabetic db/m mice...
April 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28403013/vasopressin-and-diabetic-nephropathy
#6
Ronan Roussel, Gilberto Velho, Lise Bankir
PURPOSE OF REVIEW: The prevalence of diabetic kidney disease (DKD) is increasing worldwide. Despite major therapeutic advances in the last decades in DKD, the current standard of care let many people progress to severe stages. Vasopressin secretion is increased in diabetes, and its potential role in the onset and progression of DKD is being re-investigated. RECENT FINDINGS: Recently, observational studies evidenced an association between surrogates of vasopressin secretion (daily fluid intake or urine volume, and plasma copeptin concentration) and chronic kidney disease in the community, but also specifically in type 1 and in type 2 diabetes...
April 11, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28401356/development-of-novel-nomograms-to-predict-renal-functional-outcomes-after-laparoscopic-adrenalectomy-in-patients-with-primary-aldosteronism
#7
Takanobu Utsumi, Naoto Kamiya, Mayuko Kaga, Takumi Endo, Masashi Yano, Shuichi Kamijima, Koji Kawamura, Takashi Imamoto, Tomohiko Ichikawa, Hiroyoshi Suzuki
PURPOSE: Most patients with primary aldosteronism (PA) show a significant decrease in kidney function after surgery. Glomerular hyperfiltration peculiar to PA can mask mild renal failure before surgery. The aim of this retrospective study was to investigate postoperative renal functional outcomes in PA patients from different viewpoints and to develop novel nomograms that can predict renal functional outcomes in PA patients after surgery. METHODS: 130 Japanese PA patients treated by unilateral laparoscopic adrenalectomy were retrospectively surveyed...
April 11, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28386664/determinants-of-glomerular-filtration-rate-following-bariatric-surgery-in-individuals-with-severe-otherwise-uncomplicated-obesity-an-observational-prospective-study
#8
Marta Seghieri, Edoardo Vitolo, Livia Giannini, Eleonora Santini, Chiara Rossi, Antonio Salvati, Anna Solini
AIMS: Obesity-induced nephropathy is an established clinical entity arising from a "maladaptive" response to lipid accumulation at the nephron level. Bariatric surgery positively affects renal function, reducing or increasing glomerular filtration rate (GFR) in subjects with hyperfiltration and renal impairment, respectively. The effect of this surgery in patients with normal estimated GFR (eGFR) is less clear. METHODS: A complete clinical and biochemical assessment of 135 severely obese, otherwise healthy subjects, was obtained before Roux-en-Y gastric bypass (RYGB)...
April 6, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28381464/a-pseudo-three-dimensional-model-for-quantification-of-oxygen-diffusion-from-pre-glomerular-arteries-to-renal-tissue-and-renal-venous-blood
#9
Chang-Joon Lee, Jennifer P Ngo, Saptarshi Kar, Bruce S Gardiner, Roger G Evans, David W Smith
To assess the physiological significance of arterial-to-venous (AV) oxygen shunting, we generated a new pseudo-three-dimensional computational model of oxygen diffusion from intrarenal arteries to cortical tissue and veins. The model combines the eleven branching levels (known as 'Strahler' orders) of the pre-glomerular renal vasculature in the rat, with an analysis of an extensive dataset obtained using light microscopy to estimate oxygen mass transfer coefficients for each Strahler order. Further, the AV shunting model is now set within a global oxygen transport model that includes transport from arteries, glomeruli, peritubular capillaries and veins to tissue...
April 5, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28381459/urinary-adenosine-excretion-in-type-1-diabetes
#10
Harindra Rajasekeran, Yuliya Lytvyn, Andrea Bozovic, Julie Lovshin, Eleftherios Diamandis, Daniel Cattran, Mansoor Husain, Bruce A Perkins, Andrew Advani, Heather N Reich, Vathany Kulasingam, David Z I Cherney
INTRODUCTION: In experimental models of diabetes, augmented sodium-glucose cotransport-2 (SGLT2) activity diminishes sodium (Na+) delivery at the macula densa. As a result, less vasoconstrictive adenosine is generated, leading to afferent arteriolar vasodilatation and hyperfiltration. The measurement and significance of urinary adenosine in humans has not been extensively examined in states of renal hemodynamic impairment, like that of diabetes. OBJECTIVE: Our aim was to validate a method for urine adenosine quantification in humans and perform an exploratory post-hoc analysis to determine whether urinary adenosine levels change dynamically in response to natriuresis in patients with type 1 diabetes (T1D) before and after treatment with the SGLT2 inhibitor (SGLT2i) empagliflozin...
April 5, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28374067/erratum-to-characterisation-of-glomerular-haemodynamic-responses-to-sglt2-inhibition-in-patients-with-type-1-diabetes-and-renal-hyperfiltration
#11
Marko Škrtić, Gary K Yang, Bruce A Perkins, Nima Soleymanlou, Yuliya Lytvyn, Maximilian von Eynatten, Hans J Woerle, Odd Erik Johansen, Uli C Broedl, Thomas Hach, Melvin Silverman, David Z I Cherney
No abstract text is available yet for this article.
April 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/28368024/higher-glomerular-filtration-rate-is-related-to-insulin-resistance-but-not-to-obesity-in-a-predominantly-obese-non-diabetic-cohort
#12
Negar Naderpoor, Jasmine G Lyons, Aya Mousa, Sanjeeva Ranasinha, Maximilian P J de Courten, Georgia Soldatos, Barbora de Courten
Glomerular hyperfiltration has been associated with obesity, insulin resistance, and systolic blood pressure (SBP). However, previous studies are limited by confounders such as pre-existing diabetes or hypertension, or have used indirect measures of adiposity and insulin sensitivity (IS). Therefore, we examined the relationship between estimated glomerular filtration rate (eGFR) and IS measured by the hyperinsulinaemic euglycaemic clamp in a healthy population on no medications. We performed oral glucose tolerance test (OGTT) and measured % body fat (DEXA), BMI, blood pressure and M-value (hyperinsulinaemic euglycaemic clamp) in 104 individuals (44 females and 60 males)...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28363084/the-metabolic-syndrome-induces-early-changes-in%C3%A2-the-swine-renal-medullary-mitochondria
#13
Alfonso Eirin, John R Woollard, Christopher M Ferguson, Kyra L Jordan, Hui Tang, Stephen C Textor, Amir Lerman, Lilach O Lerman
The metabolic syndrome (MetS) is associated with nutrient surplus and kidney hyperfiltration, accelerating chronic renal failure. Mitochondria can be overwhelmed by substrate excess, leading to inefficient energy production and thereby tissue hypoxia. Mitochondrial dysfunction is emerging as an important determinant of renal damage, but whether it contributes to MetS-induced renal injury remains unknown. We hypothesized that early MetS induces kidney mitochondrial abnormalities and dysfunction, which would be notable in the vulnerable renal medulla...
March 11, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28361575/obesity-and-kidney-disease-hidden-consequences-of-the-epidemic
#14
C P Kovesdy, S Furth, C Zoccali, World Kidney Day Steering Committee
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long-term...
March 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28360198/donor-recipient-weight-and-sex-mismatch-and-the-risk-of-graft-loss-in-renal-transplantation
#15
Amanda J Miller, Bryce A Kiberd, Ian P Alwayn, Ayo Odutayo, Karthik K Tennankore
BACKGROUND AND OBJECTIVES: Relatively smaller kidney donor to recipient size is proposed to result in higher graft loss due to nephron underdosing and hyperfiltration injury, but the potentially additive effect of sex and weight mismatch has not been explored in detail. The purpose of this study was to determine if concurrent donor and recipient absolute weight and sex mismatch was associated with graft loss in a cohort of deceased donor kidney transplant recipients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The association of kidney donor and recipient absolute weight and sex difference with death-censored graft loss was explored using a cohort of United States deceased donor recipients between 2000 and 2014 through the Scientific Registry of Transplants Recipients...
April 3, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28358868/precocious-obesity-predisposes-the-development-of-more-severe-cisplatin-induced-acute-kidney-injury-in-young-adult-mice
#16
Rosemara S Ribeiro, Clevia S Passos, Antônio S Novaes, Edgar Maquigussa, Maria A Glória, Iria Visoná, Olinda Ykuta, Lila M Oyama, Mirian A Boim
Obesity and its consequences can damage the kidney over time. However, less is known about the impact of developing overweight/obesity during childhood on the kidney in adulthood and the renal impact of a superimposed acute kidney injury (AKI). This study evaluated the effect of obesity induced by a high-fat diet initiated soon after weaning on the adult life of mice and their response to superimposed nephrotoxic effects of cisplatin. C57BL/6 post-weaning mice (3 weeks old) were divided into a control group (CT, n = 12) and a high-fat diet group (HF, n = 12)...
2017: PloS One
https://www.readbyqxmd.com/read/28355410/obesity-and-kidney-disease-hidden-consequences-of-the-epidemic
#17
Csaba P Kovesdy, Susan L Furth, Carmine Zoccali
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for Chronic Kidney Disease. A high body mass index is one of the strongest risk factors for new-onset Chronic Kidney Disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing Chronic Kidney Disease in the long-term...
March 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28352003/obesity-and-kidney-disease-hidden-consequences-of-the-epidemic
#18
EDITORIAL
Csaba P Kovesdy, Susan Furth, Carmine Zoccali
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long-term...
March 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28339567/role-of-biomechanical-forces-in-hyperfiltration-mediated-glomerular-injury-in-congenital-anomalies-of-the-kidney-and-urinary-tract
#19
Tarak Srivastava, Ganesh Thiagarajan, Uri S Alon, Ram Sharma, Ashraf El-Meanawy, Ellen T McCarthy, Virginia J Savin, Mukut Sharma
Congenital anomalies of the kidney and urinary tract (CAKUT) including solitary kidney constitute the main cause of progressive chronic kidney disease (CKD) in children. Children born with CAKUT develop signs of CKD only during adolescence and do not respond to renin-angiotensin-aldosterone system blockers. Early cellular changes underlying CKD progression to end-stage renal disease by early adulthood are not well understood. The mechanism of maladaptive hyperfiltration that occurs from loss of functional nephrons, including solitary kidney, is not clear...
January 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28329736/delay-in-renal-hemodynamic-response-to-a-meat-meal-in-severe-obesity
#20
Pietro Anastasio, Davide Viggiano, Miriam Zacchia, Claudia Altobelli, Giovambattista Capasso, Natale Gaspare De Santo
BACKGROUND/AIMS: Little information is available about the tubular functions and the renal adjustments that take place in obese subjects after a protein meal. How the excess fat may affect renal response to dietary proteins is currently only partially understood. This paper aims to address (i) whether severe obesity, in the absence of other comorbidities, is responsible of kidney dysfunction at either the glomerular or the tubular level and (ii) whether it compromises renal adaptations to a large protein meal...
March 23, 2017: Nephron
keyword
keyword
34084
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"