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https://www.readbyqxmd.com/read/27936104/mechanical-loading-attenuates-radiation-induced-bone-loss-in-bone-marrow-transplanted-mice
#1
Peter M Govey, Yue Zhang, Henry J Donahue
Exposure of bone to ionizing radiation, as occurs during radiotherapy for some localized malignancies and blood or bone marrow cancers, as well as during space travel, incites dose-dependent bone morbidity and increased fracture risk. Rapid trabecular and endosteal bone loss reflects acutely increased osteoclastic resorption as well as decreased bone formation due to depletion of osteoprogenitors. Because of this dysregulation of bone turnover, bone's capacity to respond to a mechanical loading stimulus in the aftermath of irradiation is unknown...
2016: PloS One
https://www.readbyqxmd.com/read/27935105/identifying-the-optimum-source-of-mesenchymal-stem-cells-for-use-in-knee-surgery
#2
Benjamin M Davies, Sarah Jb Snelling, Lynn Quek, Osnat Hakimi, Hua Ye, Andrew Carr, Andrew J Price
Single sitting procedures where the mononuclear cell fraction is extracted from bone marrow and implanted directly into cartilage and bone defects are becoming more popular as novel treatments for cartilage defects which have, until now had few treatment options. This is on the basis that the mesenchymal stem cells (MSCs) contained within will repair the damaged tissue. This study sought to determine if the femur and tibia could provide equivalent amounts of mesenchymal stem cells, with equivalent viability and proliferative capacity, to that obtained from the gold standard of the pelvis in order to potentially reduce the morbidity associated with these procedures...
December 9, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27933268/autologous-platelet-lysates-local-injections-for-treatment-of-tibia-non-union-with-breakage-of-the-nickelclad-a-case-report
#3
Hong-Jiang Jiang, Xun-Xiang Tan, Hai-Yang Ju, Jin-Ping Su, Wei Yan, Xiu-Gang Song, Li-Wu Qin, Chang-Jun Ju, Ling-Shuang Wang, De-Bao Zou
BACKGROUND: Nonunions of the tibia represent challenging orthopedic problems, which require the surgeon to analyze numerous factors and choose an appropriate treatment. This article presents a case report of tibia and fibula fracture patient who failed the internal fixation surgery and successfully recovered after one course of percutaneous autologous platelet lysates injection. CASE DESCRIPTION: The patient received an internal nickelclad breakage at 9 months post-surgery but reluctant to accept a second surgery, then autologous platelet lysates (APL) injection which is a less invasive method was recommended...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933212/spontaneous-destructive-periodontitis-and-skeletal-bone-damage-in-transgenic-mice-carrying-a-human-shared-epitope-coding-hla-drb1-allele
#4
Prashasnika Gehlot, Sarah L Volk, Hector F Rios, Karl J Jepsen, Joseph Holoshitz
OBJECTIVE: Shared epitope (SE)-coding DRB1 alleles are associated with bone erosion in several diseases, including rheumatoid arthritis (RA) and periodontal disease (PD), but the underlying mechanism is unknown. We have recently identified the SE as an osteoclast-activating ligand. To better understand the biological effects of the SE in vivo, here we sought to determine whether it can facilitate spontaneous bone damage in naïve mice. METHODS: 3-month old naïve transgenic mice that carry the human SE-coding allele DRB1*04:01, or a SE-negative allele DRB1*04:02 were studied...
2016: RMD Open
https://www.readbyqxmd.com/read/27929692/osteoporotic-animal-models-of-bone-healing-advantages-and-pitfalls
#5
Elena Calciolari, Nikolaos Donos, Nikos Mardas
The aim of this review was to summarize the advantages and pitfalls of the available osteoporotic animal models of bone healing. A thorough literature search was performed in MEDLINE via OVID and EMBASE to identify animal studies investigating the effect of experimental osteoporosis on bone healing and bone regeneration. The osteotomy model in the proximal tibia is the most popular osseous defect model to study the bone healing process in osteoporotic-like conditions, although other well-characterized models, such as the post-extraction model, might be taken into consideration by future studies...
December 8, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27926984/involvement-of-chemokine-cxcl11-in-the-development-of-morphine-tolerance-in-rats-with-cancer-induced-bone-pain
#6
Genhua Guo, Yawen Peng, Bingrui Xiong, Daiqiang Liu, Huilian Bu, Xuebi Tian, Hui Yang, Zhen Wu, Fei Cao, Feng Gao
Morphine is viewed as one of the classical treatments for intractable pain, but its role is limited by side effects, including analgesic tolerance. A few chemokines have been reported to be engaged in the mechanisms of morphine tolerance. However, the exact roles of CXCL11 in chronic morphine tolerance remain unknown. In this study, Walker 256 mammary gland carcinoma cells were inoculated into the tibia of rats to provoke cancer-induced bone pain (CIBP). Then morphine was intrathecally administered twice daily for 7 consecutive days to induce drug tolerance...
December 7, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27923624/a-novel-3d-approach-for-determination-of-frontal-and-coronal-plane-tibial-slopes-from-mr-imaging
#7
Amirhesam Amerinatanzi, Rodney Summers, Kaveh Ahmadi, Vijay K Goel, Timothy E Hewett, Edward Nyman
BACKGROUND: The proximal tibia is geometrically complex, asymmetrical, and variable, is heavily implicated in arthrokinematics of the knee joint, and thus a contributor to knee pathologies such as non-contact anterior cruciate ligament injury. Medial, lateral, and coronal tibial slopes are anatomic parameters that may increase predisposition to knee injuries, but the extent to which each contributes has yet to be fully realized. Previously, two-dimensional methods have quantified tibial slopes, but more reliable 3D methods may prove advantageous...
December 3, 2016: Knee
https://www.readbyqxmd.com/read/27922193/phagocytosis-of-collagen-fibrils-by-fibroblasts-in-vivo-is-independent-of-the-uparap-endo180-receptor
#8
Sara Sprangers, Niels Behrendt, Lars Engelholm, Yixuan Cao, Vincent Everts
As a crucial step in ECM remodeling, collagen degradation occurs through different processes, including both extracellular and intracellular degradation. The extracellular pathways of collagen degradation require secretion of collagenolytic proteases, whereas intracellular collagen degradation occurs in the lysosomal compartment after uptake, involving either pre-cleaved or intact fibrillar collagen. The endocytic collagen receptor uPARAP/Endo180 plays an important role in internalization of large collagen degradation products, whereas its role in the phagocytosis of fibrillar collagen has been debated...
December 6, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27921147/can-the-alendronate-dosage-be-altered-when-combined-with-high-frequency-loading-in-osteoporosis-treatment
#9
C B Correa, G V Camargos, M Chatterjee, M F Mesquita, A A Del Bel Cury, I Naert, J Duyck, K Vandamme
: Alendronate therapy has been associated with serious side effects. Altering the alendronate concentration and combining with high-frequency loading as mechanical intervention was explored in this animal study as a treatment for osteoporosis. The bone anabolic potency of high-frequency loading was overruled by the different alendronate dosages applied in the present study. Further exploration of reduced hormonal therapy associated with mechanical interventions in osteoporosis treatment should be sought...
December 5, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27921146/bone-loss-at-the-distal-femur-and-proximal-tibia-in-persons-with-spinal-cord-injury-imaging-approaches-risk-of-fracture-and-potential-treatment-options
#10
REVIEW
C M Cirnigliaro, M J Myslinski, M F La Fountaine, S C Kirshblum, G F Forrest, W A Bauman
Persons with spinal cord injury (SCI) undergo immediate unloading of the skeleton and, as a result, have severe bone loss below the level of lesion associated with increased risk of long-bone fractures. The pattern of bone loss in individuals with SCI differs from other forms of secondary osteoporosis because the skeleton above the level of lesion remains unaffected, while marked bone loss occurs in the regions of neurological impairment. Striking demineralization of the trabecular epiphyses of the distal femur (supracondylar) and proximal tibia occurs, with the knee region being highly vulnerable to fracture because many accidents occur while sitting in a wheelchair, making the knee region the first point of contact to any applied force...
December 5, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27921145/compressive-loading-of-the-murine-tibia-reveals-site-specific-micro-scale-differences-in-adaptation-and-maturation-rates-of-bone
#11
I Bergström, J G Kerns, A E Törnqvist, C Perdikouri, N Mathavan, A Koskela, H B Henriksson, J Tuukkanen, G Andersson, H Isaksson, A E Goodship, S H Windahl
: Loading increases bone mass and strength in a site-specific manner; however, possible effects of loading on bone matrix composition have not been evaluated. Site-specific structural and material properties of mouse bone were analyzed on the macro- and micro/molecular scale in the presence and absence of axial loading. The response of bone to load is heterogeneous, adapting at molecular, micro-, and macro-levels. INTRODUCTION: Osteoporosis is a degenerative disease resulting in reduced bone mineral density, structure, and strength...
December 5, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27920333/accuracy-and-reproducibility-using-patient-specific-instrumentation-in-total-ankle-arthroplasty
#12
Justin Daigre, Gregory Berlet, Bryan Van Dyke, Kyle S Peterson, Robert Santrock
BACKGROUND: Implant survivorship is dependent on accuracy of implantation and successful soft tissue balancing. System instrumentation for total ankle arthroplasty implantation has a key influence on surgeon accuracy and reproducibility. The purpose of this study was to determine the accuracy and reproducibility of implant position with patient-specific guides for total ankle arthroplasty across multiple surgeons at multiple facilities. METHODS: This retrospective, multicenter study included 44 patients who received a total ankle implant (INBONE II Total Ankle System; Wright Medical Technology, Memphis, TN) using PROPHECY patient-specific guides from January 2012 to December 2014...
December 5, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27920197/supplementation-of-fine-and-coarse-limestone-in-different-ratios-in-a-split-feeding-system-effects-on-performance-egg-quality-and-bone-strength-in-old-laying-hens
#13
A Molnár, L Maertens, B Ampe, J Buyse, J Zoons, E Delezie
Different ratios of fine- (FL) and coarse limestone (CL) were compared (50FL:50CL, 30FL:70CL, 0FL:100CL) in conventional (C) and split feeding (S) for their effects on performance, egg quality traits, and bone quality of old, brown laying hens (72 to 83 wk). Each treatment consisted of 42 hens (7 hens × 6 replicates). In the C system diets supplemented with limestone were provided during the whole day, whereas in the S system a morning diet was fed without added limestone, and only the afternoon diet was supplemented with different limestone ratios...
December 5, 2016: Poultry Science
https://www.readbyqxmd.com/read/27919515/sexual-dimorphism-of-the-tibia-in-contemporary-greek-cypriots-and-cretans-forensic-applications
#14
E K Kranioti, J G García-Donas, P S Almeida Prado, X P Kyriakou, H C Langstaff
Sex estimation is an essential step in the identification process of unknown heavily decomposed human remains as it eliminates all possible matches of the opposite sex from the missing person's database. Osteometric methods constitute a reliable approach for sex estimation and considering the variation of sexual dimorphism between and within populations; standards for specific populations are required to ensure accurate results. The current study aspires to contribute osteometric data on the tibia from contemporary Greek-Cypriots to assist the identification process...
November 16, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27918596/degeneration-in-acl-injured-knees-with-and-without-reconstruction-in-relation-to-muscle-size-and-fat-content-data-from-the-osteoarthritis-initiative
#15
Pia M Jungmann, Thomas Baum, Michael C Nevitt, Lorenzo Nardo, Alexandra S Gersing, Nancy E Lane, Charles E McCulloch, Ernst J Rummeny, Thomas M Link
BACKGROUND: Anterior cruciate ligaments (ACL) injuries represent a major risk factor for early osteoarthritis (OA). PURPOSE: To evaluate the prevalence and 4-year progression of knee OA measured with 3T MR-imaging in individuals with ruptured, reconstructed or normal ACL and to assess the impact of thigh muscle characteristics. METHODS: A total of 54 knees (23/54 male, 31/54 female) were recruited from the Osteoarthritis Initiative (OAI). At baseline, 15/54 subjects had prevalent ACL ruptures and 15/54 subjects had prevalent ACL reconstruction (24/54 normal ACL)...
2016: PloS One
https://www.readbyqxmd.com/read/27917329/minimally-invasive-treatment-of-tibial-pilon-fractures-through-arthroscopy-and-external-fixator-assisted-reduction
#16
Huasong Luo, Liaobin Chen, Kebin Liu, Songming Peng, Jien Zhang, Yang Yi
OBJECTIVE: The aim of this study was to evaluate the clinical outcome of tibial pilon fractures treated with arthroscopy and assisted reduction with an external fixator. METHODS: Thirteen patients with tibial pilon fractures underwent assisted reduction for limited lower internal fixation with an external fixator under arthroscopic guidance. The weight-bearing time was decided on the basis of repeat radiography of the tibia 3 months after surgery. Postoperative ankle function was evaluated according to the Mazur scoring system...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27916576/extensor-reconstruction-of-the-knee-using-the-fibular-transposition-technique-after-proximal-tibial-resection
#17
Hiroyuki Kawashima, Akira Ogose, Tetsuo Hotta, Takashi Ariizumi, Tetsuro Yamagishi, Naoto Endo
BACKGROUND: Reconstruction of the extensor mechanism after resection of the proximal tibia is challenging, and several surgical procedures are available. The purpose of this study was to determine the outcome of the fibular transposition technique for reconstruction of the extensor mechanism of the knee after proximal tibial resection. METHODS: We retrospectively reviewed five consecutive patients who underwent resection of the proximal tibia with prosthetic reconstruction and reconstruction of the extensor using fibular transposition between 1997 and 2011...
December 1, 2016: Knee
https://www.readbyqxmd.com/read/27914011/activation-of-alpha-7-nicotinic-acetylcholine-receptor-reduces-brain-edema-in-mice-with-ischemic-stroke-and-bone-fracture
#18
Dingquan Zou, Man Luo, Zhenying Han, Lei Zhan, Wan Zhu, Shuai Kang, Chen Bao, Zhao Li, Jeffrey Nelson, Rui Zhang, Hua Su
Stroke is an important risk factor for bone fracture. We showed previously that bone fracture at the acute stage of ischemic stroke worsens, and activation of α-7 nicotinic acetylcholine receptor (α-7 nAchR) improves, stroke recovery by attenuating inflammation. We hypothesized that activation of α-7 nAchR also improves the blood-brain barrier (BBB) integrity. Permanent distal middle cerebral artery occlusion (pMCAO) was performed on C57BL/6J mice followed by tibia fracture 1 day later. Mice were treated with 0...
December 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27912929/survival-failure-modes-and-function-of-combined-distal-femur-and-proximal-tibia-reconstruction-following-tumor-resection
#19
F Sevelda, W Waldstein, J Panotopoulos, C Stihsen, A Kaider, P T Funovics, R Windhager
BACKGROUND: Tumor spread to the knee joint or skip metastasis to the adjacent bones of the knee require reconstruction with combined distal femur and proximal tibia replacements. The literature on implant survival and failure modes with this type of reconstruction is sparse. The goals of this study were to determine the implant survival, the different failure modes and the functional outcome of this megaendoprosthetic reconstruction. PATIENTS AND METHODS: Thirty-nine patients with combined distal femur and proximal tibia reconstruction were retrospectively reviewed...
November 23, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27909861/surgical-reconstruction-for-fibular-hemimelia
#20
REVIEW
Dror Paley
Fibular hemimelia presents with foot deformity and leg length discrepancy. Previous classifications have focused on the degree of fibular deficiency rather than the type of foot deformity. Published methods of surgical reconstruction have often failed due to residual or recurrent foot deformity. The purpose of this report is to introduce new classification and reconstruction methods. The Paley SHORDT procedure is used to stabilize the ankle when there is a hypoplastic distal fibula with a dynamic valgus deformity...
December 2016: Journal of Children's Orthopaedics
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