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https://www.readbyqxmd.com/read/28441666/a-microrna-124-polymorphism-is-associated-with-fracture-healing-via-modulating-bmp6-expression
#1
Lin Zou, Guichun Zhang, Lifeng Liu, Chen Chen, Xuecheng Cao, Jinfang Cai
BACKGROUND: miR-124-3p has been reported to be involved in the pathogenesis of many diseases by modulating a variety of signaling pathways. In this study, we aimed to understand the impact of miR-124-3p expression level on the fracture healing in the patients of metaphyseal fracture of distal tibia, who received minimal invasive percutaneous plate osteosynthesis. METHODS: We firstly collected 195 patients of metaphyseal fracture of distal tibia, and the genotype of rs531564 was determined: GG (n=124) and GC+CC (n=71)...
April 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28441320/hyperbaric-oxygen-therapy-is-ineffective-as-an-adjuvant-to-daptomycin-with-rifampicin-treatment-in-a-murine-model-of-staphylococcus-aureus-in-implant-associated-osteomyelitis
#2
Nis Pedersen Jørgensen, Kasper Hansen, Caroline Marie Andreasen, Michael Pedersen, Kurt Fuursted, Rikke L Meyer, Eskild Petersen
Implant-associated infections caused by bacterial biofilms are difficult to treat. Surgical intervention is often necessary to cure the patient, as the antibiotic recalcitrance of biofilms renders them untreatable with conventional antibiotics. Intermittent hyperbaric oxygen treatment (HBOT) has been proposed as an adjuvant to conventional antibiotic treatment and it has been speculated that combining HBOT with antibiotics could improve treatment outcomes for biofilm infections. In this study we addressed whether HBOT could improve treatment outcomes of daptomycin and rifampicin combination therapy...
April 25, 2017: Microorganisms
https://www.readbyqxmd.com/read/28439468/a-link-between-central-kynurenine-metabolism-and-bone-strength-in-rats-with-chronic-kidney-disease
#3
Bartlomiej Kalaska, Krystyna Pawlak, Ewa Oksztulska-Kolanek, Tomasz Domaniewski, Beata Znorko, Malgorzata Karbowska, Aleksandra Citkowska, Joanna Rogalska, Alicja Roszczenko, Malgorzata M Brzoska, Dariusz Pawlak
BACKGROUND: Disturbances in mineral and bone metabolism represent one of the most complex complications of chronic kidney disease (CKD). Serotonin, a monoamine synthesized from tryptophan, may play a potential role in bone metabolism. Brain-derived serotonin exerts a positive effect on the bone structure by limiting bone resorption and enhancing bone formation. Tryptophan is the precursor not only to the serotonin but also and primarily to kynurenine metabolites. The ultimate aim of the present study was to determine the association between central kynurenine metabolism and biomechanical as well as geometrical properties of bone in the experimental model of the early stage of CKD...
2017: PeerJ
https://www.readbyqxmd.com/read/28439314/correction-of-lower-limb-deformities-in-children-with-renal-osteodystrophy-by-guided-growth-technique
#4
C Gigante, A Borgo, M Corradin
PURPOSE: Renal osteodystrophy (ROD) may cause severe lower limb deformities in children. The purpose of this study is to evaluate the efficacy of the temporary hemiepiphysiodesis for the correction of lower limb deformities in children with ROD. METHODS: Guided growth correction by hemiepiphysiodesis has been performed in skeletally immature patients with deformities of the lower limbs caused by ROD. The correction of the mechanical axes of the lower limbs and its correction speed have been evaluated...
2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28439305/costal-cartilage-transplantation-for-treatment-of-growth-plate-injury-in-a-rabbit-model
#5
D Otsuki, K Yoshida, M Kobayashi, D Hamano, C Higuchi, H Yoshikawa
OBJECTIVES: The purpose of this study is to evaluate the effects of allogenic costal cartilage transplantation on preventing bony bridge formation and angular deformities for the treatment of partial growth plate injury using a rabbit model. METHODS: An experimental model of partial growth injury was created by resecting the medial part of the proximal tibial growth plate in male six-week-old New Zealand White rabbits. The rabbits were divided into four groups: no surgery; no transplantation; bone wax transplantation; and allogenic costal cartilage transplantation...
2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28439203/cystic-tuberculosis-osteomyelitis-of-the-distal-tibia-in-infancy
#6
Seyit Ali Gümüştaş, Talat Çağırmaz, Mehmet Müfit Orak, Gökhan Pehlivanoğlu, Sedat Öktem
One-third of tuberculosis cases affect the musculoskeletal system. Solitary bone tuberculosis is a rare condition in infancy, has non-specific findings, and can be misdiagnosed easily. Cystic form tuberculosis may mimic many other pathologic conditions. In our case report, we present tuberculosis osteomyelitis of the distal tibia in a baby aged ten months who visited our outpatient department with swelling and pain in their left ankle. Curettage and debridement was performed twice for the lesion. An under-knee splint was applied for 3 months and anti-tuberculosis treatment was given for 12 months...
March 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28438966/mediation-of-movement-induced-breakthrough-cancer-pain-by-ib4-binding-nociceptors-in-rats
#7
Joshua Havelin, Ian Imbert, Devki Sukhtankar, Bethany Remeniuk, Ian Pelletier, Jonathan Gentry, Alec Okun, Timothy Tiutan, Frank Porreca, Tamara King
Cancer-induced bone pain (CIBP) is characterized by moderate to severe ongoing pain that commonly requires the use of opiates. Even when ongoing pain is well controlled, patients can suffer breakthrough pain (BTP), episodic severe pain that "breaks through" the medication. We developed a novel model of cancer-induced BTP using female rats with mammary adenocarcinoma cells sealed within the tibia. We previously demonstrated that rats with bone cancer learn to prefer a context paired with saphenous nerve block to elicit pain relief (i...
April 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28438417/comparing-hospital-outcomes-between-open-and-closed-tibia-fractures-treated-with-intramedullary-fixation
#8
Evan J Smith, Xiangyu Kuang, Rajeev Pandarinath
INTRODUCTION: Tibial shaft fractures comprise a large portion of operatively treated long bone fractures, and present with the highest rate of open injuries. Intramedullary fixation has become the standard of care for both open and closed injuries. The rates of short term complications and hospital length of stay for open and closed fractures treated with intramedullary fixation is not fully known. Previous series on tibia fractures were performed at high volume centers, and data were not generalizable, further they did not report on length of stay and the impact of preoperative variables on infections, complications and reoperation...
March 30, 2017: Injury
https://www.readbyqxmd.com/read/28438404/quantitative-ultrasound-and-tibial-dysplasia-in-neurofibromatosis-type-1
#9
David A Stevenson, Heather Hanson, Austin Stevens, John Carey, David Viskochil, Xiaoming Sheng, Karen Wheeler, Hillarie Slater
Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder associated with unilateral anterolateral bowing with subsequent fracture and nonunion. In infancy, physiologic bowing of the lower leg can be confused with pathologic tibial dysplasia in NF1. Little is known about the bone physiology of the tibiae prior to fracture or predictors of fracture. The aim of this study was to characterize bone quality of bowed tibiae prior to fracture in NF1 using quantitative ultrasound (QUS). Bone quality was assessed on both tibiae (the non-bowed and bowed tibiae) using QUS to measure speed of sound (SOS) at the mid-shaft in 23 individuals with NF1...
April 21, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28437505/guidelines-for-treatment-of-lateral-patella-dislocations-in-skeletally-mature-patients
#10
Michael C Liebensteiner, Florian Dirisamer, Peter Balcarek, Philip Schoettle
The incidence of lateral patella dislocations is high, particularly in young females. Beside traumatic cases, many patients present with specific anatomical factors that predispose to lateral patella dislocations (torsional abnormalities of the femur or the tibia, trochlea dysplasia, patella alta, etc). It is of utmost importance to correct those pathologic factors during concomitant procedures as isolated reconstructions of the medial patellofemoral ligament would fail in the presence of severe anatomic risk factors...
March 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28437504/effect-of-plate-in-close-proximity-to-empty-external-fixation-pin-site-on-long-bone-torsional-strength
#11
Fred L Speck, Randal P Morris, Ronald W Lindsey
Complex tibia fractures are often provisionally stabilized with external fixation prior to definitive fracture fixation. Bicortical defects, such as those left after removal of a fixator pin, can decrease the torsional strength of long bone. Evaluating the effect of subsequent plate fixation in close proximity to a defect on the torsional strength of the tibia is the purpose of this study. Eight groups of 5 fourth-generation left composite tibias were tested to failure in torsion. The experimental plated groups consisted of bicortical defects at 3 cm, 2 cm, and 1 cm distal to the plate end, with 1 plated group without a defect...
March 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28437289/congenital-pseudarthrosis-of-the-tibia
#12
Courtney O'Donnell, James Foster, Ryan Mooney, Corey Beebe, Nathan Donaldson, Travis Heare
No abstract text is available yet for this article.
April 21, 2017: JBJS Reviews
https://www.readbyqxmd.com/read/28437193/evaluation-of-the-effects-of-photobiomodulation-on-biomechanical-properties-and-hounsfield-unit-of-partial-osteotomy-healing-in-an-experimental-rat-model-of-type-i-diabetes-and-osteoporosis
#13
Ataroalsadat Mostafavinia, Reza Ahadi, Mohammadamin Abdollahifar, Seyed Kamran Ghorishi, Ali Jalalifirouzkouhi, Mohammad Bayat
BACKGROUND: Pulsed wave (PW) lasers exhibit biostimulatory effects on fractures in healthy and diabetic animals. OBJECTIVE: This study aims to assess the effects of photobiomodulation on bone strength and Hounsfield unit (HU) for repair of a bone defect in an experimental rat model of type I diabetes mellitus (TIDM) and osteoporosis (OP). METHODS: We divided 30 female rats into six groups of n = 5 per group: (1) ovariectomy (OVX) control, (2) OVX + PW laser and no TIDM, (3) OVX control + TIDM, (4) OVX + TIDM + PW laser, (5) OVX + TIDM + alendronate, and (6) OVX + TIDM + PW laser + alendronate...
February 22, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28435849/effects-of-cyclic-compression-on-the-mechanical-properties-and-calcification-process-of-immature-chick-bone-tissue-in-culture
#14
Eijiro Maeda, Masashi Nakagaki, Katsuhisa Ichikawa, Kazuaki Nagayama, Takeo Matsumoto
Contribution of mechanical loading to tissue growth during both the development and post-natal maturation is of a particular interest, as its understanding would be important to strategies in bone tissue engineering and regenerative medicine. The present study has been performed to investigate how immature bone responds to mechanical loading using an ex vivo culture system. A slice of the tibia, with the thickness of 3 mm, was obtained from 0-day-old chick. For the ex vivo culture experiment in conjunction with cyclic compressive loading, we developed a custom-made, bioreactor system where both the load and the deformation applied to the specimen was recorded...
June 2017: Bone Reports
https://www.readbyqxmd.com/read/28435567/role-of-antibiotic-cement-coated-nailing-in-infected-nonunion-of-tibia
#15
C Bhatia, A K Tiwari, S B Sharma, S Thalanki, A Rai
INTRODUCTION: Infected nonunion of long bones is a chronic and debilitating disorder. It is more difficult to deal with when the implant used for internal fixation itself becomes a potential media for infection because of bacterial adhesion and biofilm formation. Traditionally, it is managed by two-stage procedure for controlling the infection first and then treating the nonunion. This study has been undertaken to explore antibiotic cement coated nailing as single stage treatment modality for treating infection and achieving stability at the same time...
March 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28435561/solitary-osteochondroma-of-the-tibial-tuberosity-mimicking-osgood-schlatter-lesion-a-rare-cause-of-anterior-knee-pain-in-adolescents-a-case-report
#16
G Balaji, P Palaniappan, S Nema, J Menon
Osteochondroma arising from the tibial tuberosity is very rare. We report such a case which mimicked OsgoodSchlatter's disease in an adolescent. A 12 years-old boy presented with swelling over his right proximal tibia of one year duration associated with pain in the last three months. Examination revealed a 4 x 2cm bony mass arising from the proximal tibia. Radiographs revealed an osteochondroma of the tibial tuberosity. Computer tomography and magnetic resonance imaging confirmed the continuity of the medulla of the bony mass to that of the parent bone...
July 2016: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28435556/anterior-knee-pain-after-tibial-intra-medullary-nailing-is-it-predictable
#17
P C Soraganvi, B S Anand-Kumar, R Rajagopalakrishnan, B A Praveen-Kumar
Introduction: Intramedullary nailing has been used frequently for the treatment of tibial diaphyseal fractures. Chronic anterior knee pain has been considered the most frequent post-operative complication of this technique. We investigated the relationship between anterior knee pain and position of nail tip in proximal tibia. Methods: 103 patients were selected among patients who underwent interlocking nailing in our institution. Patients with other factors that might cause anterior knee pain were excluded...
July 2016: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28435382/myobiid-mites-trombidiformes-myobiidae-of-the-golden-bat-mimon-cozumelae-from-mexico-description-of-the-male-and-tritonymph-of-ioanella-mimon-and-new-records-of-eudusbabekia-mimon
#18
Angel Herrera-Mares, Carmen Guzmán-Cornejo, Livia León-Paniagua, Gerardo Rivas
The male and the tritonymph of Ioanella mimon are described for the first time parasitizing to Mimon cozumelae from Yucatan, Mexico. Male of Ioanella mimon is characterized by the presence of legs I with the tibia and tarsus fused forming a small complex devoided of apical claws, legs II-IV with two claws, setae vi at level of anterior end of genital plate, genital plate rounded with an anterior projection, all intercoxal setae short; while the tritonymph is characterized by the presence of legs I unequal; legs II-IV with 2-1-1 claws, and posterior region of dorsal idiosoma with 3 pairs of cylindrical and toothed setae...
2017: ZooKeys
https://www.readbyqxmd.com/read/28434057/predictive-control-of-intersegmental-tarsal-movements-in-an-insect
#19
Alicia Costalago-Meruelo, David M Simpson, Sandor M Veres, Philip L Newland
In many animals intersegmental reflexes are important for postural and movement control but are still poorly undesrtood. Mathematical methods can be used to model the responses to stimulation, and thus go beyond a simple description of responses to specific inputs. Here we analyse an intersegmental reflex of the foot (tarsus) of the locust hind leg, which raises the tarsus when the tibia is flexed and depresses it when the tibia is extended. A novel method is described to measure and quantify the intersegmental responses of the tarsus to a stimulus to the femoro-tibial chordotonal organ...
April 22, 2017: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/28432058/mk5-haplodefficiency-attenuates-hypertrophy-and-preserves-diastolic-function-during-remodeling-induced-by-chronic-pressure-overload-in-the-mouse-heart
#20
Sherin Nawaito, Dharmendra Dingar, Pramod Sahadevan, Bahira Hussein, Fatiha Sahmi, Yanfen Shi, Marc-Antoine Gillis, Matthias Gaestel, Jean-Claude Tardif, Bruce G Allen
MK5 is a protein serine and threonine kinase that is activated by p38 MAPK and the atypical MAPKs ERK3 and ERK4. The physiological function(s) of MK5 remain unknown. Herein we examine the effect of MK5 haplodeficiency on cardiac function and myocardial remodeling. At 12-weeks of age, MK5 haplodeficient mice (MK5(+/-)) were smaller than age-matched wild-type litter mates (MK5(+/+)), with similar diastolic function but reduced systolic function. Transverse aortic constriction (TAC) was employed to induce a chronic pressure overload in twelve-week-old male MK5(+/-) and MK5(+/+) mice...
April 21, 2017: American Journal of Physiology. Heart and Circulatory Physiology
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