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https://www.readbyqxmd.com/read/28343295/identification-of-sphingosine-1-phosphate-receptor-subtype-1-s1p1-as-a-pathogenic-factor-in-transient-focal-cerebral-ischemia
#1
Bhakta Prasad Gaire, Chi-Ho Lee, Arjun Sapkota, Sang Yeul Lee, Jerold Chun, Hee Jun Cho, Tae-Gyu Nam, Ji Woong Choi
Medically relevant roles of receptor-mediated sphingosine 1-phosphate (S1P) signaling have become a successful or promising target for multiple sclerosis or cerebral ischemia. Animal-based proof-of-concept validation for the latter is particularly through the neuroprotective efficacy of FTY720, a non-selective S1P receptor modulator, presumably via activation of S1P1. In spite of a clear link between S1P signaling and cerebral ischemia, it remains unknown whether the role of S1P1 is pathogenic or neuroprotective...
March 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28343137/synthesis-of-novel-muramic-acid-derivatives-and-their-interaction-with-lysozyme-action-of-lysozyme-revisited
#2
Manas Jana, Anirban Ghosh, Abhishek Santra, Rajiv Kumar Kar, Anup Kumar Misra, Anirban Bhunia
HYPOTHESIS: The interaction of lysozyme with the N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) unit of peptidoglycan (PGN) polymer of the bacterial cell wall is of immense importance to understand the mechanism of lysozyme on PGN. EXPERIMENTS: The synthesis of three novel NAM derivatives containing fused oxazinone ring to the NAM moiety has been achieved. The synthesized compounds were evaluated for their potential as a glycomimetic acceptor of lysozyme using different biophysical and computational methods such as (1)H NMR, STD NMR, DOSY and Molecular docking...
March 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28342390/lidocaine-gel-versus-plain-lubricating-gel-for-pain-reduction-during-transrectal-sonography-lips-a-randomized-controlled-trial
#3
Su Hyun Nam, Kye Hyun Kim, Chahien Choi, Se Hyun Nam, Taejong Song, Kyo Won Lee
OBJECTIVE: To compare the efficacy and safety of lidocaine gel and plain lubricating gel in relieving pain during transrectal sonography (TRS) in patients with gynecologic problems. METHODS: A randomized controlled trial was conducted in 80 participants who were scheduled to undergo TRS. The participants were allocated into the lidocaine gel group and the aqueous gel group at a 1:1 ratio. The intensity of pain during TRS based on the visual analogue scale (0-10 points) and the adverse events were assessed and compared between the two groups...
March 11, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28339719/the-pepper-wpp-domain-protein-cawdp1-acts-as-a-novel-negative-regulator-of-drought-stress-via-aba-signaling
#4
Chanmi Park, Chae Woo Lim, Woonhee Baek, Jung-Hyun Kim, Sohee Lim, Sang Hyon Kim, Kyung-Nam Kim, Sung Chul Lee
Plants are constantly challenged by various environmental stresses, including high salinity and drought, and they have evolved defense mechanisms to counteract the deleterious effects of these stresses. The plant hormone abscisic acid (ABA) regulates plant growth and developmental processes and mediates abiotic stress responses. Here, we report the identification and characterization of a novel CaWDP1 (Capsicum annuumWPP Domain Protein 1) protein. The expression of CaWDP1 in pepper leaves was induced by ABA, drought, and NaCl treatments, suggesting its role in the abiotic stress response...
February 22, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28339435/impact-of-celiac-plexus-neurolysis-on-survival-in-patients-with-unresectable-pancreatic-cancer-a-retrospective-propensity-score-matching-analysis
#5
Tak Kyu Oh, Woo Jin Lee, Sang Myung Woo, Nam Woo Kim, Jiyeon Yim, Dae Hyun Kim
BACKGROUND: Pain caused by pancreatic cancer (PC) is difficult to control. Celiac plexus neurolysis (CPN) can effectively control the pain and reduce the use of opioids. However, the effect of CPN on survival for patients with unresectable PC remains controversial. OBJECTIVES: To determine if CPN is associated with survival benefits for these patients. STUDY DESIGN: Retrospective, observational cohort study. SETTING: National Cancer Center in Korea...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28337999/comparison-of-validation-and-application-on-various-cardiovascular-disease-mortality-risk-prediction-models-in-chinese-rural-population
#6
Changqing Sun, Fei Xu, Xiaotian Liu, Mingwang Fang, Hao Zhou, Yixiao Lian, Chen Xie, Nan Sun, Chongjian Wang
This research aims to assess application of different cardiovascular disease (CVD) mortality risk prediction models in Chinese rural population. Data was collected from a 6-year follow-up survey in rural area of Henan Province, China. 10338 participants aged 40 to 65 years were included. Baseline study was conducted between 2007 and 2008, and followed up from 2013 to 2014. Seven models: general Framingham risk score (general-FRS), simplified-FRS, Systematic Coronary Risk Evaluation for high (SCORE-high), SCORE-low, Chinese ischemic CVD (CN-ICVD), Pooled Cohort Risk Equation for white (PCE-white) and for African-American (PCE-AA) were assessed and recalibrated...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337985/synthesis-and-reactivity-of-a-mononuclear-non-haem-cobalt-iv-oxo-complex
#7
Bin Wang, Yong-Min Lee, Woon-Young Tcho, Samat Tussupbayev, Seoung-Tae Kim, Yujeong Kim, Mi Sook Seo, Kyung-Bin Cho, Yavuz Dede, Brenna C Keegan, Takashi Ogura, Sun Hee Kim, Takehiro Ohta, Mu-Hyun Baik, Kallol Ray, Jason Shearer, Wonwoo Nam
Terminal cobalt(IV)-oxo (Co(IV)-O) species have been implicated as key intermediates in various cobalt-mediated oxidation reactions. Herein we report the photocatalytic generation of a mononuclear non-haem [(13-TMC)Co(IV)(O)](2+) (2) by irradiating [Co(II)(13-TMC)(CF3SO3)](+) (1) in the presence of [Ru(II)(bpy)3](2+), Na2S2O8, and water as an oxygen source. The intermediate 2 was also obtained by reacting 1 with an artificial oxidant (that is, iodosylbenzene) and characterized by various spectroscopic techniques...
March 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28335561/optimal-power-allocation-of-relay-sensor-node-capable-of-energy-harvesting-in-cooperative-cognitive-radio-network
#8
Pham Ngoc Son, Dongsoo Har, Nam Ik Cho, Hyung Yun Kong
A cooperative cognitive radio scheme exploiting primary signals for energy harvesting is proposed. The relay sensor node denoted as the secondary transmitter (ST) harvests energy from the primary signal transmitted from the primary transmitter, and then uses it to transmit power superposed codes of the secrecy signal of the secondary network (SN) and of the primary signal of the primary network (PN). The harvested energy is split into two parts according to a power splitting ratio, one for decoding the primary signal and the other for charging the battery...
March 21, 2017: Sensors
https://www.readbyqxmd.com/read/28335385/patient-posture-monitoring-system-based-on-flexible-sensors
#9
Youngsu Cha, Kihyuk Nam, Doik Kim
Monitoring patients using vision cameras can cause privacy intrusion problems. In this paper, we propose a patient position monitoring system based on a patient cloth with unobtrusive sensors. We use flexible sensors based on polyvinylidene fluoride, which is a flexible piezoelectric material. Theflexiblesensorsareinsertedintopartsclosetothekneeandhipoftheloosepatientcloth. We measure electrical signals from the sensors caused by the piezoelectric effect when the knee and hip in the cloth are bent. The measured sensor outputs are transferred to a computer via Bluetooth...
March 13, 2017: Sensors
https://www.readbyqxmd.com/read/28335353/the-chemical-deposition-method-for-the-decoration-of-palladium-particles-on-carbon-nanofibers-with-rapid-conductivity-changes
#10
Hoik Lee, Duy-Nam Phan, Myungwoong Kim, Daewon Sohn, Seong-Geun Oh, Seong Hun Kim, Ick Soo Kim
Palladium (Pd) metal is well-known for hydrogen sensing material due to its high sensitivity and selectivity toward hydrogen, and is able to detect hydrogen at near room temperature. In this work, palladium-doped carbon nanofibers (Pd/CNFs) were successfully produced in a facile manner via electrospinning. Well-organized and uniformly distributed Pd was observed in microscopic images of the resultant nanofibers. Hydrogen causes an increment in the volume of Pd due to the ability of hydrogen atoms to occupy the octahedral interstitial positions within its face centered cubic lattice structure, resulting in the resistance transition of Pd/CNFs...
November 29, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335277/receptor-meditated-endocytosis-by-hyaluronic-acid-superparamagnetic-nanovetor-for-targeting-of-cd44-overexpressing-tumor-cells
#11
Kwang Sik Yu, Meng Meng Lin, Hyun-Ju Lee, Ki-Sik Tae, Bo-Sun Kang, Je Hun Lee, Nam Seob Lee, Young Gil Jeong, Seung-Yun Han, Do Kyung Kim
The present report proposes a more rational hyaluronic acid (HA) conjugation protocol that can be used to modify the surface of the superparamagnetic iron oxide nanoparticles (SPIONs) by covalently binding the targeting molecules (HA) with glutamic acid as a molecular linker on peripheral surface of SPIONs. The synthesis of HA-Glutamic Acid (GA)@SPIONs was included oxidization of nanoparticle's surface with H₂O₂ followed by activation of hydroxyl group and reacting glutamic acid as an intermediate molecule demonstrating transfection of lung cancer cells...
August 18, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28333197/bilayered-structure-of-the-superficial-facial-fascia
#12
Hyun Gu Kang, Kwan-Hyun Youn, In-Beom Kim, Yong Seok Nam
Background: The superficial facial fascia comprises the superficial musculoaponeurotic system (SMAS) and the temporoparietal fascia (TPF) and is regarded as a continuous monolayer. However, some evidence indicates that the superficial facial fascia consists of 2 layers in specific areas. Objectives: The authors evaluated the superficial facial fascia for bilayered regions. Methods: Twenty fresh cadavers (40 hemifaces) were dissected to observe the superficial facial fascia...
February 20, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28333152/radiation-inducible-mir-770-5p-sensitizes-tumors-to-radiation-through-direct-targeting-of-pdz-binding-kinase
#13
Hyung Chul Lee, Nam-Gu Her, Donghee Kang, Seung Hee Jung, Jinwook Shin, Minyoung Lee, In Hwa Bae, Young-Nyun Kim, Heon Joo Park, Young-Gyu Ko, Jae-Seon Lee
Radiotherapy represents the most effective non-surgical modality in cancer treatment. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression, and are involved in many biological processes and diseases. To identify miRNAs that influence the radiation response, we performed miRNA array analysis using MCF7 cells at 2, 8, and 24 h post irradiation. We demonstrated that miR-770-5p is a novel radiation-inducible miRNA. When miR-770-5p was overexpressed, relative cell number was reduced due to increased apoptosis in MCF7 and A549 cells...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28332824/indole-substituted-benzothiazoles-and-benzoxazoles-as-selective-and-reversible-mao-b-inhibitors-for-treatment-of-parkinson-s-disease
#14
Min-Ho Nam, Moosung Park, Hyeri Park, Youngjae Kim, Seulki Yoon, Vikram Shahaji Sawant, Ji Won Choi, Jong-Hyun Park, Ki Duk Park, Sun-Joon Min, Changjoon Justin Lee, Hyunah Choo
To develop a novel, selective, and reversible MAO-B inhibitors for safer treatment of Parkinson's disease, benzothiazole and benzoxazole derivatives with indole moiety were designed and synthesized. Most of the synthesized compounds showed inhibitory activities against MAO-B and selectivity over MAO-A. The most active compound was Compound 5b, 6-fluoro-2-(1-methyl-1H-indol-5-yl)benzo[d]thiazole with an IC50 value of 29 nM with no apparent effect on MAO-A activity at 10 M. Based on the reversibility assay, Compound 5b turned out to be a fully reversible with over 95% of recovery of enzyme activity after washout of the compound...
March 23, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28332479/3d-tissue-formation-by-stacking-detachable-cell-sheets-formed-on-nanofiber-mesh
#15
Min Sung Kim, Byungjun Lee, Hong Nam Kim, Seokyoung Bang, Hee Seok Yang, Seong Min Kang, Kahp-Yang Suh, Suk-Hee Park, Noo Li Jeon
We present a novel approach for assembling 3D tissue by layer-by-layer stacking of cell sheets formed on aligned nanofiber mesh. A rigid frame was used to repeatedly collect aligned electrospun PCL (polycaprolactone) nanofiber to form a mesh structure with average distance between fibers 6.4 µm. When human umbilical vein endothelial cells (HUVECs), human foreskin dermal fibroblasts, and skeletal muscle cells (C2C12) were cultured on the nanofiber mesh, they formed confluent monolayers and could be handled as continuous cell sheets with areas 3 × 3 cm(2) or larger...
March 23, 2017: Biofabrication
https://www.readbyqxmd.com/read/28332378/quantitative-computed-tomographic-volumetry-after-treatment-of-a-giant-intracranial-aneurysm-with-a-pipeline-embolization-device
#16
Woong Jae Lee, Jun Soo Byun, Jae Kyun Kim, Taek Kyun Nam
Recently developed flow diverters, such as the pipeline embolization device (PED), allow for safe and efficacious treatment of giant intracranial aneurysms, with high occlusion rates and a low incidence of complications. However, incomplete obliteration after PED treatment may lead to aneurysm regrowth and delayed rupture. Herein, we report a case of a partially thrombosed giant aneurysm of the cavernous internal carotid artery that showed progressive recanalization at 1-3 months after application of a PED...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28332355/long-term-prognosis-of-patients-with-an-implantable-cardioverter-defibrillator-in-korea
#17
Jae Sun Uhm, Tae Hoon Kim, In Cheol Kim, Young Ah Park, Dong Geum Shin, Yeong Min Lim, Hee Tae Yu, Pil Sung Yang, Hui Nam Pak, Seok Min Kang, Moon Hyoung Lee, Boyoung Joung
PURPOSE: The objective of this study was to elucidate the long-term prognosis of patients with implantable cardioverter-defibrillators (ICDs) in Korea. MATERIALS AND METHODS: We enrolled 405 patients (age, 57.7±16.7 years; 311 men) who had undergone ICD implantation. The patients were divided into three groups: heart failure (HF) and ICD for primary (group 1, n=118) and secondary prevention (group 2, n=93) and non-HF (group 3, n=194). We compared appropriate and inappropriate ICD therapy delivery among the groups and between high- (heart rate ≥200 /min) and low-rate (<200 /min) ICD therapy zones...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28332354/cyclized-oligopeptide-targeting-lrp5-6-dkk1-interaction-reduces-the-growth-of-tumor-burden-in-a-multiple-myeloma-mouse-model
#18
Bo Mi Park, Eun Jin Kim, Hee Jin Nam, Dongdong Zhang, Chu Hyun Bae, Myeongmo Kang, Heeyoun Kim, Weontae Lee, Bjarne Bogen, Sung Kil Lim
PURPOSE: Dickkopf 1 (DKK1) has been extensively investigated in mouse models of multiple myeloma, which results in osteolytic bone lesions. Elevated DKK1 levels in bone marrow plasma and serum inhibit the differentiation of osteoblast precursors. Present pharmaceutical approaches to target bone lesions are limited to antiresorptive agents. In this study, we developed a cyclized oligopeptide against DKK1-low density lipoprotein receptor-related protein (LRP) 5/6 interaction and tested the effects of the oligopeptide on tumor burden...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28332257/exomic-variants-of-an-elderly-cohort-of-brazilians-in-the-abraom%C3%A2-database
#19
Michel Satya Naslavsky, Guilherme Lopes Yamamoto, Tatiana Ferreira de Almeida, Suzana A M Ezquina, Daniele Yumi Sunaga, Nam Pho, Daniel Bozoklian, Tatiana Orli Milkewitz Sandberg, Luciano Abreu Brito, Monize Lazar, Danilo Vicensotto Bernardo, Edson Amaro, Yeda A O Duarte, Maria Lúcia Lebrão, Maria Rita Passos-Bueno, Mayana Zatz
Brazilians are highly admixed with ancestry from Europe, Africa, America, and Asia yet still underrepresented in genomic databanks. We hereby present a collection of exomic variants from 609 elderly Brazilians in a census-based cohort (SABE609) with comprehensive phenotyping. Variants were deposited in ABraOM (Online Archive of Brazilian Mutations), a web-based public database. Population representative phenotype and genotype repositories are essential for variant interpretation through allele frequency filtering; since elderly individuals are less likely to harbor pathogenic mutations for early and adult-onset diseases, such variant databases are of great interest...
March 23, 2017: Human Mutation
https://www.readbyqxmd.com/read/28331171/accelerated-ecotoxicity-of-photoreactive-nanoparticles-on-moina-macrocopa
#20
Sun-Hwa Nam, Yu-Jin Shin, Youn-Joo An
Zinc oxide nanoparticles (ZnO NPs) and titanium dioxide nanoparticles (TiO2 NPs) are well known as photoreactive NPs. Various phototoxicity of ZnO NPs and TiO2 NPs on several organisms were reported. There was still necessity to evaluate toxicity of photoreactive ZnO NPs and TiO2 NPs due to species-specific effects under various irradiation conditions. We compared acute toxicity of Moina macrocopa under visible, UVA, and UVB irradiations, according to Organization for Economic Cooperation and Development guidelines for the testing of chemicals (Test No...
March 22, 2017: Environmental Health and Toxicology
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