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https://www.readbyqxmd.com/read/28231414/mir-135a-3p-as-a-promising-biomarker-and-nucleic-acid-therapeutic-agent-for-ovarian-cancer
#1
Satoshi Fukagawa, Kohei Miyata, Fusanori Yotsumoto, Chihiro Kiyoshima, Sung Ouk Nam, Haruchika Anan, Takahiro Katsuda, Daisuke Miyahara, Masaharu Murata, Hiroshi Yagi, Kyoko Shirota, Shin'ichiro Yasunaga, Kiyoko Kato, Shingo Miyamoto
Ovarian cancer is the most lethal gynecologic malignancy. Recently, several molecularly targeted anticancer agents have been developed for ovarian cancer; however, its prognosis has remained extremely poor. The development of molecularly targeted therapy, as well as companion diagnostics, is required to improve outcomes for patients with ovarian cancer. In this study, to identify microRNAs involved in the progression of ovarian cancer we analyzed serum microRNAs in patients with ovarian cancer using microRNA array and qRT-PCR and examined the anticancer properties of microRNA expression in ovarian cancer cells...
February 23, 2017: Cancer Science
https://www.readbyqxmd.com/read/28231319/development-of-a-keratinase-activity-assay-using-recombinant-chicken-feather-keratin-substrates
#2
Hyeon-Su Jin, Seon Yeong Park, Kyungmin Kim, Yong-Jik Lee, Gae-Won Nam, Nam Joo Kang, Dong-Woo Lee
Poultry feathers consist mainly of the protein keratin, which is rich in β-pleated sheets and consequently resistant to proteolysis. Although many keratinases have been identified, the reasons for their substrate specificity towards β-keratin remain unclear due to difficulties in preparing a soluble feather keratin substrate for use in activity assays. In the present study, we overexpressed Gallus gallus chromosomes 2 and 27 β-keratin-encoding genes in Escherichia coli, purified denatured recombinant proteins by Ni2+ affinity chromatography, and refolded by stepwise dialysis to yield soluble keratins...
2017: PloS One
https://www.readbyqxmd.com/read/28230594/alveolar-molding-effect-in-infants-with-unilateral-cleft-lip-and-palate-comparison-of-two-and-three-dimensional-measurements
#3
Won Hee Lim, Eun Woo Park, Hwa Sung Chae, Soon Man Kwon, Hoi-In Jung, Seung-Hak Baek
The purpose of this study was to compare the results of two- (2D) and three-dimensional (3D) measurements for the alveolar molding effect in patients with unilateral cleft lip and palate. The sample consisted of 23 unilateral cleft lip and palate infants treated with nasoalveolar molding (NAM) appliance. Dental models were fabricated at initial visit (T0; mean age, 23.5 days after birth) and after alveolar molding therapy (T1; mean duration, 83 days). For 3D measurement, virtual models were constructed using a laser scanner and 3D software...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28230573/global-sagittal-imbalance-due-to-change-in-pelvic-incidence-after-traumatic-spinopelvic-dissociation
#4
Han-Dong Lee, Chang-Hoon Jeon, Nam-Su Chung, Suk-Hyeong Won
OBJECTIVES: Traumatic spinopelvic dissociation separates the spinal column from the pelvis, which usually creates lumbosacral kyphosis. We aimed to examine how the spinopelvic profiles changes after traumatic spinopelvic dissociation, and which are the relevant factors for the sagittal imbalance of the spine. DESIGN: Retrospective analysis. SETTING: Level I trauma center PATIENTS:: Thirty-nine consecutive patients who were diagnosed with traumatic spinopelvic dissociation and had a minimum 2-year radiological follow-up were included...
February 20, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28228465/prognostic-value-of-residual-urine-volume-gfr-by-24-hour-urine-collection-and-egfr-in-patients-receiving-dialysis
#5
Mi Jung Lee, Jung Tak Park, Kyoung Sook Park, Young Eun Kwon, Hyung Jung Oh, Tae-Hyun Yoo, Yong-Lim Kim, Yon Su Kim, Chul Woo Yang, Nam-Ho Kim, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND AND OBJECTIVES: Residual kidney function can be assessed by simply measuring urine volume, calculating GFR using 24-hour urine collection, or estimating GFR using the proposed equation (eGFR). We aimed to investigate the relative prognostic value of these residual kidney function parameters in patients on dialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using the database from a nationwide prospective cohort study, we compared differential implications of the residual kidney function indices in 1946 patients on dialysis at 36 dialysis centers in Korea between August 1, 2008 and December 31, 2014...
February 22, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28227712/a-preliminary-study-of-a-running-speed-based-heart-rate-prediction-during-an-incremental-treadmill-exercise
#6
Dae-Geun Jang, Byung-Hoon Ko, Sub Sunoo, Sang-Seok Nam, Hun-Young Park, Sang-Kon Bae, Dae-Geun Jang, Byung-Hoon Ko, Sub Sunoo, Sang-Seok Nam, Hun-Young Park, Sang-Kon Bae, Byung-Hoon Ko, Sang-Kon Bae, Sub Sunoo, Dae-Geun Jang, Hun-Young Park, Sang-Seok Nam
This preliminary study investigates feasibility of a running speed based heart rate (HR) prediction. It is basically motivated from the assumption that there is a significant relationship between HR and the running speed. In order to verify the assumption, HR and running speed data from 217 subjects of varying aerobic capabilities were simultaneously collected during an incremental treadmill exercise. A running speed was defined as a treadmill speed and its corresponding heart rate was calculated by averaging the last one minute HR values of each session...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227589/uhf-wearable-battery-free-sensor-module-for-activity-and-falling-detection
#7
Nam Trung Dang, Thang Viet Tran, Wan-Young Chung, Nam Trung Dang, Thang Viet Tran, Wan-Young Chung, Thang Viet Tran, Wan-Young Chung, Nam Trung Dang
Falling is one of the most serious medical and social problems in aging population. Therefore taking care of the elderly by detecting activity and falling for preventing and mitigating the injuries caused by falls needs to be concerned. This study proposes a wearable, wireless, battery free ultra-high frequency (UHF) smart sensor tag module for falling and activity detection. The proposed tag is powered by UHF RF wave from reader and read by a standard UHF Electronic Product Code (EPC) Class-1 Generation-2 reader...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225566/polyaniline-stabilized-intertwined-network-like-ferrocene-graphene-nano-architecture-for-supercapacitor-application
#8
Amrita De Adhikari, Ramesh Oraon, Santosh Kumar Tiwari, Naresh K Jena, Joong Hee Lee, Nam Hoon Kim, Ganesh Nayak
The present work highlights the effective H-π interaction between metallocene (Ferrocene (Fc)) and graphene and their stabilization in presence of Polyaniline (PANI) via π-π interaction. PANI stabilized Fc@graphene nanocomposite resembled an interwined network like morphology with high surface area and porosity can make it a potential candidate for energy storage application. A theoretical (DFT) study has also revealed the various interaction energy between the components. Specific capacitance calculated from galvanostatic charging discharging presented that PANI stabilized ternary nanocomposite exhibited maximum specific capacitance of 960 F/g at energy density 85 Wh/Kg at current density 1 A/g ...
February 22, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28225356/improving-mechanical-properties-of-carbon-nanotube-fibers-through-simultaneous-solid-state-cycloaddition-and-crosslinking
#9
Nam-Goo Kang, Xinyi Lu, Nitilaksha Hiremath, Kunlun Hong, Maria Evora, Victoria Ranson, Amit Naskar, Gajanan Bhat, Jimmy Mays
Individual carbon nanotubes (CNTs) exhibit exceptional mechanical properties. However, difficulties remain to fully realize these properties in CNT macro-assemblies, because of the sliding past one another resulting from the weak inter-tube forces. Herein, a simple solid-state reaction is presented that enhances the mechanical properties of carbon nanotube fibers (CNTFs) through simultaneous covalent functionalization and crosslinking. This is the first chemical crosslinking proposed without involvement of catalyst or byproducts...
February 22, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28225339/latent-tuberculous-infection-in-household-contacts-of-multidrug-resistant-and-newly-diagnosed-tuberculosis
#10
G J Fox, N T Anh, N V Nhung, N T Loi, N B Hoa, L T Ngoc Anh, N K Cuong, T N Buu, G B Marks, D Menzies
BACKGROUND: Differences in the prevalence of latent tuberculous infection (LTBI) and tuberculosis (TB) disease among contacts of patients with multidrug-resistant TB (MDR-TB) and drug-susceptible TB are not well understood. OBJECTIVE: To compare the prevalence of tuberculin skin test (TST) positivity in household contacts of patients with MDR-TB and in contacts of patients never previously treated for TB ('new TB'). DESIGN: Consecutive patients with MDR-TB and their household contacts at nine urban district clinics in Viet Nam were screened for TB and LTBI, and followed up for 6 months...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28224775/laboratory-identification-of-leptotrichia-species-isolated-from-bacteremia-patients-at-a-single-institution
#11
Eun Hye Cho, Kyung Sun Park, Mina Yang, Dong Joon Song, Hee Jae Huh, Chang Seok Ki, Nam Yong Lee
We describe the laboratory identification of Leptotrichia species from clinical isolates collected over a six-year period. Five isolates from blood cultures were identified as Leptotrichia species. Gram stain showed large, fusiform, gram-negative or -variable bacilli. Identification based on biochemical testing was unsuccessful; however, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry proved to be a useful tool for identifying Leptotrichia species to the genus level. Species level identification was successfully achieved by using 16S ribosomal RNA gene sequencing...
May 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28224695/distal-hyperintense-vessel-sign-is-associated-with-neurological-deterioration-in-acute-ischaemic-stroke
#12
K-W Nam, H-M Kwon, S-W Park, J-S Lim, M-K Han, Y-S Lee
BACKGROUND AND PURPOSE: The aim was to evaluate the relationship between distal hyperintense vessel sign (HVS) and early neurological deterioration (END) in acute ischaemic stroke with large vessel steno-occlusion. METHODS: Acute ischaemic stroke patients with symptomatic severe steno-occlusion in the middle cerebral artery or internal carotid artery were recruited within 24 h from symptom onset. Stroke outcomes were evaluated using the National Institutes of Health Stroke Scale (NIHSS) score at the time of admission and at 72 h and 7 days...
February 22, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28224644/clinical-effect-of-intratympanic-dexamethasone-injection-in-acute-unilateral-tinnitus-a-prospective-placebo-controlled-multicenter-study
#13
Hyun-Jin Lee, Min-Beom Kim, Shin-Young Yoo, Shi Nae Park, Eui-Cheol Nam, In Seok Moon, Ho-Ki Lee
OBJECTIVE: The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection (ITDI) in acute tinnitus of presumed cochlear origin. STUDY DESIGN: A prospective, randomized, placebo-controlled, double-blinded, multicenter study. METHODS: Between August 2013 and December 2015, 54 patients with unilateral tinnitus were enrolled at four different centers. Patients were assigned either to an ITDI (n = 27) or an intratympanic normal saline injection (ITNI; n = 27) group through block randomization...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28223751/secondary-cutaneous-amyloidosis-in-a-patient-with-mycosis-fungoides
#14
Chan Hee Nam, Min Kee Park, Mi Soo Choi, Seung Phil Hong, Byung Cheol Park, Myung Hwa Kim
Secondary cutaneous amyloidosis refers to clinically unapparent amyloid deposits within the skin in association with a pre-existing skin condition or skin tumors, such as basal cell carcinoma, porokeratosis, solar elastosis, Bowen's disease, and mycosis fungoides. A 70-year-old woman presented with a 6-month history of asymptomatic multiple yellowish plaques on both legs. She had been diagnosed with mycosis fungoides 7 years ago and was treated with psoralen and ultraviolet A radiation (PUVA) therapy, narrow-band ultraviolet B (UVB) therapy, and acitretin for 5 years...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28223426/resistance-mechanism-against-trastuzumab-in-her2-positive-cancer-cells-and-its-negation-by-src-inhibition
#15
Mei Hua Jin, Ah-Rong Nam, Ji Eun Park, Ju-Hee Bang, Yung-Jue Bang, Do-Youn Oh
Trastuzumab in combination with chemotherapy is the standard of care for patients with human epidermal growth factor receptor 2 (HER2)-positive breast and gastric cancers. Several resistance mechanisms against anti-HER2 therapy have been proposed. Src activation has been suggested to be responsible for the resistance of HER2-positive breast cancer. In our study, we generated four trastuzumab-resistant (HR) cancer cell lines from HER2-amplified gastric and biliary tract cancer cell lines (SNU-216, NCI-N87, SNU-2670, and SNU-2773)...
February 21, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28223175/high-fatality-rates-and-associated-factors-in-two-hospital-outbreaks-of-mers-in-daejeon-the-republic-of-korea
#16
Hae-Sung Nam, Jung Wan Park, Moran Ki, Mi-Yeon Yeon, Jin Kim, Seung Woo Kim
OBJECTIVES: To explore the epidemiological and clinical factors predictive of the case fatality rate (CFR) of Middle East respiratory syndrome-coronavirus (MERS-CoV) infection in an outbreak in Daejeon, the Republic of Korea. METHODS: We reviewed the outbreak investigation reports and medical records of 1 index case and 25 additional MERS cases in hospitals A (14 cases) and B (11 cases), and conducted an in-depth interview with the index case. RESULTS: The CFR in hospital B was higher than that in hospital A (63...
February 18, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28222967/clinical-implications-of-microscopic-extrathyroidal-extension-in-patients-with-papillary-thyroid-carcinoma
#17
Ji Su Park, Jae Won Chang, Lihua Liu, Seung-Nam Jung, Bon Seok Koo
BACKGROUND: Extrathyroidal extension (ETE) is a poor prognostic factor in papillary thyroid carcinoma (PTC). However, the impact of the degree of ETE, especially microscopic ETE, has not been well established. The purpose of present study was to compare differences in clinicopathological characteristics and clinical outcomes according to the presence or extent of ETE. METHODS: Data from 381 patients who underwent total thyroidectomy with/without lymph node (LN) dissection for PTC between 2004 and 2010 were analyzed...
February 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28222243/studies-on-the-binding-of-modest-modulators-of-the-human-enzyme-sirtuin-6-using-std-nmr
#18
Beatriz E Bolívar, John T Welch
Pyrazinamide (PZA), an essential constituent of short course tuberculosis chemotherapy, binds weakly but selectively to Sirtuin 6 (SIRT6). Despite structural similarities between nicotinamide (NAM), PZA, and pyrazinoic acid (POA), these inhibitors modulate SIRT6 via different mechanisms and binding sites, as suggested by Saturation Transfer Difference (STD) Nuclear Magnetic Resonance (NMR). Available experimental evidence, such as that derived from crystal structures and kinetic experiments, is of only limited utility in the elucidation of the mechanistic details of sirtuin inhibition by NAM or other inhibitors...
February 21, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28220916/magnetic-digital-microfluidics-a-review
#19
REVIEW
Yi Zhang, Nam-Trung Nguyen
A digital microfluidic platform manipulates droplets on an open surface. Magnetic digital microfluidics utilizes magnetic forces for actuation and offers unique advantages compared to other digital microfluidic platforms. First, the magnetic particles used in magnetic digital microfluidics have multiple functions. In addition to serving as actuators, they also provide a functional solid substrate for molecule binding, which enables a wide range of applications in molecular diagnostics and immunodiagnostics...
February 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28220585/sleep-duration-is-associated-with-body-fat-and-muscle-mass-and-waist-to-height-ratio-beyond-conventional-obesity-parameters-in-korean-adolescent-boys
#20
Ga Eun Nam, Kyungdo Han, Do Hoon Kim, Jee Hyun Lee, Won Hee Seo
While evidence has supported a strong association between sleep duration and obesity globally, results from studies of children and adolescents have been conflicting, and information about a sex-specific association has been limited. This study aimed to investigate the association of sleep duration with various parameters of obesity among South Korean adolescents. This population-based, cross-sectional study analysed the data obtained from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2009 and 2010...
February 21, 2017: Journal of Sleep Research
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