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https://www.readbyqxmd.com/read/29352447/long-term-endocrine-effects-and-trends-in-body-mass-index-changes-in-patients-with-childhood-onset-brain-tumors
#1
Go Hun Seo, Jin-Ho Choi, Yoon-Myung Kim, Kyung-Nam Koh, Ho Joon Im, Young Shin Ra, Han-Wook Yoo
As survival rates have improved owing to advances in management strategies for pediatric brain tumors, long-term complications such as endocrine dysfunction, have emerged as a major issue. This study investigated the long-term endocrine effects of childhood-onset brain tumors in a large number of patients. This study included 151 patients with brain tumors diagnosed between January 1995 and December 2016. The following data were retrospectively reviewed: tumor location, tumor histology, endocrine abnormalities, hypothalamic involvement on brain imaging, treatment modalities, and trends in body mass index...
January 19, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29352338/predictive-factors-for-lymph-node-metastasis-in-submucosal-invasive-colorectal-carcinoma-a-new-proposal-of-depth-of-invasion-for-radical-surgery
#2
Jeonghee Han, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
BACKGROUND: Patients with lymph node metastasis (LNM) in submucosal invasive colorectal carcinoma (SM cancer) require additional surgical treatment after endoscopic dissection. However, because additional radical resection after endoscopic local resection may be unnecessary for cases without LNM, more specific criteria are required in order to diminish the incidence of further radical resection after endoscopic dissection. METHODS: A total of 492 patients with biopsy-proven SM cancer who underwent curative surgery between January 2008 and December 2012 were collected and were divided into LNM group and no LNM group...
January 19, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29352305/correction-functional-implications-of-hexameric-assembly-of-rraa-proteins-from-vibrio-vulnificus
#3
Saemee Song, Seokho Hong, Jinyang Jang, Ji-Hyun Yeom, Nohra Park, Jaejin Lee, Yeri Lim, Jun-Yeong Jeon, Hyung-Kyoon Choi, Minho Lee, Nam-Chul Ha, Kangseok Lee
[This corrects the article DOI: 10.1371/journal.pone.0190064.].
2018: PloS One
https://www.readbyqxmd.com/read/29352247/high-content-analysis-identifies-unique-morphological-features-of-reprogrammed-cardiomyocytes
#4
Matthew D Sutcliffe, Philip M Tan, Antonio Fernandez-Perez, Young-Jae Nam, Nikhil V Munshi, Jeffrey J Saucerman
Direct reprogramming of fibroblasts into cardiomyocytes is a promising approach for cardiac regeneration but still faces challenges in efficiently generating mature cardiomyocytes. Systematic optimization of reprogramming protocols requires scalable, objective methods to assess cellular phenotype beyond what is captured by transcriptional signatures alone. To address this question, we automatically segmented reprogrammed cardiomyocytes from immunofluorescence images and analyzed cell morphology. We also introduce a method to quantify sarcomere structure using Haralick texture features, called SarcOmere Texture Analysis (SOTA)...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352161/the-action-of-a-negative-allosteric-modulator-at-the-dopamine-d2-receptor-is-dependent-upon-sodium-ions
#5
Christopher J Draper-Joyce, Ravi Kumar Verma, Mayako Michino, Jeremy Shonberg, Anitha Kopinathan, Carmen Klein Herenbrink, Peter J Scammells, Ben Capuano, Ara M Abramyan, David M Thal, Jonathan A Javitch, Arthur Christopoulos, Lei Shi, J Robert Lane
Sodium ions (Na+) allosterically modulate the binding of orthosteric agonists and antagonists to many class A G protein-coupled receptors, including the dopamine D2 receptor (D2R). Experimental and computational evidences have revealed that this effect is mediated by the binding of Na+ to a conserved site located beneath the orthosteric binding site (OBS). SB269652 acts as a negative allosteric modulator (NAM) of the D2R that adopts an extended bitopic pose, in which the tetrahydroisoquinoline moiety interacts with the OBS and the indole-2-carboxamide moiety occupies a secondary binding pocket (SBP)...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351157/association-between-cotinine-verified-smoking-status-and-risk-of-colorectal-neoplasia
#6
Nam Hee Kim, Yoon Suk Jung, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
GOALS: We evaluated the association of urinary cotinine-verified smoking status with the risk of colorectal neoplasia (CRN). BACKGROUND: Many studies have reported the association between the risk of CRN and smoking status, based on self-reported questionnaires. Although self-reported smoking status may be inaccurate, to our knowledge, no study has yet assessed the association between objective biomarkers of tobacco exposure and the risk of CRN. STUDY: A cross-sectional study was conducted on 96,806 asymptomatic examinees who underwent colonoscopy and urinary cotinine measurements as part of a health check-up...
January 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29351029/factors-associated-with-adherence-to-nasoalveolar-molding-nam-by-caregivers-of-infants-born-with-cleft-lip-and-palate
#7
Nick O Esmonde, Judah S Garfinkle, Yiyi Chen, William E Lambert, Anna A Kuang
OBJECTIVE: Identify factors associated with adherence to nasoalveolar molding (NAM) therapy. DESIGN: Retrospective case-control study. SETTING: Tertiary referral center. PATIENTS, PARTICIPANTS: Infants with cleft lip, with or without cleft palate, referred for NAM. One hundred thirty-five patients met criteria. MAIN OUTCOME MEASURE(S): Adherence to NAM therapy, defined as continuous use of the appliance and attendance of NAM adjustment visits...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29349940/etiology-of-invasive-bacterial-infections-in-immunocompetent-children-in-korea-2006-2010-a-retrospective-multicenter-study
#8
Kyuyol Rhie, Eun Hwa Choi, Eun Young Cho, Jina Lee, Jin Han Kang, Dong Soo Kim, Yae Jean Kim, Youngmin Ahn, Byung Wook Eun, Sung Hee Oh, Sung Ho Cha, Young Jin Hong, Kwang Nam Kim, Nam Hee Kim, Yun Kyung Kim, Jong Hyun Kim, Taekjin Lee, Hwang Min Kim, Kun Song Lee, Chun Soo Kim, Su Eun Park, Young Mi Kim, Chi Eun Oh, Sang Hyuk Ma, Dae Sun Jo, Young Youn Choi, Hoan Jong Lee
BACKGROUND: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. METHODS: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. RESULTS: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age...
February 5, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29349597/drug-repurposing-screening-identifies-bortezomib-and-panobinostat-as-drugs-targeting-cancer-associated-fibroblasts-cafs-by-synergistic-induction-of-apoptosis
#9
Hak-Min Lee, Eunmyong Lee, So-Young Yeo, Sang Shin, Hyun-Kyu Park, Do-Hyun Nam, Seok-Hyung Kim
Cancer associated fibroblasts (CAFs) are the most abundant components of cancer-microenvironment. They play important roles in cancer initiation, progression, and metastasis. In addition, CAFs can confer drug-resistance to cancer cells. Considering their pro-tumorigenic roles, it is recommended to remove CAFs to prevent cancer recurrence after chemotherapy. Despite their clinical significance, few anti-CAF drugs have been developed. The objective of this study was to find a drug that could suppress the viability of patient-derived CAFs through repurposed screening of 51 drugs that were in clinical trials or received FDA approval...
January 18, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29349204/validity-of-a-scale-of-neighbourhood-informal-social-control-relevant-to-pre-schoolers-physical-activity-a-cross-sectional-study
#10
Ester Cerin, Yi Nam Suen, Anthony Barnett, Wendy Y J Huang, Robin R Mellecker
Childhood physical activity (PA) is important for health across the lifespan. Time pre-schoolers spend outdoors, which has been associated with more PA, is likely influenced by parents' perception of neighbourhood informal social control relevant to pre-schoolers' PA, defined as the willingness of neighbours to intervene to ensure social order and a safe community environment for young children's active play. To advance measurement of this construct, we assessed factorial and construct validities of the PA-related neighbourhood informal social control scale for parents of pre-schoolers (PANISC-PP)...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29349102/data-on-the-clinical-usefulness-of-brachial-ankle-pulse-wave-velocity-in-patients-with-suspected-coronary-artery-disease
#11
In-Chang Hwang, Kwang Nam Jin, Hack-Lyoung Kim, You-Nui Kim, Moon-Sun Im, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim
Brachial-artery pulse wave velocity (baPWV) is a simple and reliable tool for measurement of arterial stiffness. Our previous studies suggested that baPWV is associated with the presence and severity of coronary artery disease (CAD) and the risk of cardiovascular events. In the present data article, we provided supplementary data supporting the independent prognostic value of arterial stiffness, assessed by baPWV, in patients with suspected CAD (Hwang et al., 2017) [1]. The data was obtained from 523 patients undergoing coronary CT angiography (CCTA), and baPWV was measured at the time of CCTA...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29349050/a-comparison-of-the-local-flap-and-skin-graft-by-location-of-face-in-reconstruction-after-resection-of-facial-skin-cancer
#12
Kyung Suk Lee, Jun Oh Kim, Nam Gyun Kim, Yoon Jung Lee, Young Ji Park, Jun Sik Kim
Background: Surgery for reconstruction of defects after surgery should be performed selectively and the many points must be considered. The authors conducted this study to compare the local flap and skin graft by facial location in the reconstruction after resection of facial skin cancer. Methods: The authors performed the study in patients that had received treatment in Department of Plastic Surgery, Gyeongsang National University. The cases were analyzed according to the reconstruction methods for the defects after surgery, sex, age, tumor site, and tumor size...
December 2017: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29348850/novel-indazole-based-small-compounds-enhance-trail-induced-apoptosis-by-inhibiting-the-mkk7-tiprl-interaction-in-hepatocellular-carcinoma
#13
Ji-Yong Yoon, Jeong-Ju Lee, Sujin Gu, Myoung Eun Jung, Hyun-Soo Cho, Jung Hwa Lim, Soo Young Jun, Jun-Ho Ahn, Ju-Sik Min, Min-Hyuk Choi, Su-Jin Jeon, Yong-Jae Lee, Areum Go, Yun-Jeong Heo, Cho-Rok Jung, Gildon Choi, Kwangho Lee, Moon-Kook Jeon, Nam-Soon Kim
Hepatocellular carcinoma (HCC) is one of the most malignant tumors. Although various treatments, such as surgery and chemotherapy, have been developed, a novel alternative therapeutic approach for HCC therapy is urgently needed. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a promising anti-cancer agent, but many cancer cells are resistant to TRAIL-induced apoptosis. To help overcome TRAIL resistance in HCC cancer cells, we have identified novel chemical compounds that act as TRAIL sensitizers...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348730/black-ginseng-activates-akt-signaling-thereby-enhancing-myoblast-differentiation-and-myotube-growth
#14
Soo-Yeon Lee, Ga-Yeon Go, Tuan Anh Vuong, Jee Won Kim, Sullim Lee, Ayoung Jo, Jun Min An, Su-Nam Kim, Dong-Wan Seo, Jin-Seok Kim, Yong Kee Kim, Jong-Sun Kang, Sang-Jin Lee, Gyu-Un Bae
Background: Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not yet been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy. Methods: BG-treated C2C12 myoblasts were differentiated, followed by immunoblotting for myogenic regulators, immunostaining for a muscle marker, myosin heavy chain or immunoprecipitation analysis for myogenic transcription factors...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348726/photoaging-protective-effects-of-biogf1k-a-compound-k-rich-fraction-prepared-from-panax-ginseng
#15
Yo Han Hong, Donghyun Kim, Gibaeg Nam, Sulgi Yoo, Sang Yun Han, Seong-Gu Jeong, Eunji Kim, Deok Jeong, Keejung Yoon, Sunggyu Kim, Junseong Park, Jae Youl Cho
Background: BIOGF1K, a compound-K-rich fraction, has been shown to display anti-inflammatory activity. Although Panax ginseng is widely used for the prevention of photoaging events induced by UVB irradiation, the effect of BIOGF1K on photoaging has not yet been examined. In this study, we investigated the effects of BIOGF1K on UVB-induced photoaging events. Methods: We analyzed the ability of BIOGF1K to prevent UVB-induced apoptosis, enhance matrix metalloproteinase (MMP) expression, upregulate anti-inflammatory activity, reduce sirtuin 1 expression, and melanin production using reverse transcription-polymerase chain reaction, melanin content assay, tyrosinase assay, and flow cytometry...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348721/rare-ginsenoside-ia-synthesized-from-f1-by-cloning-and-overexpression-of-the-udp-glycosyltransferase-gene-from-bacillus%C3%A2-subtilis-synthesis-characterization-and-in%C3%A2-vitro-melanogenesis%C3%A2-inhibition-activity-in-bl6b16-cells
#16
Dan-Dan Wang, Yan Jin, Chao Wang, Yeon-Ju Kim, Zuly Elizabeth Jimenez Perez, Nam In Baek, Ramya Mathiyalagan, Josua Markus, Deok-Chun Yang
Background: Ginsenoside F1 has been described to possess skin-whitening effects on humans. We aimed to synthesize a new ginsenoside derivative from F1 and investigate its cytotoxicity and melanogenesis inhibitory activity in B16BL6 cells using recombinant glycosyltransferase enzyme. Glycosylation has the advantage of synthesizing rare chemical compounds from common compounds with great ease. Methods: UDP-glycosyltransferase (BSGT1) gene from Bacillus subtilis was selected for cloning...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348093/antifungal-and-cytotoxic-activities-of-selected-medicinal-plants-from-malaysia
#17
Yik Sin Chan, Yit Hong Cheah, Poh Zen Chong, Hui Lai Khor, Wen Siang Teh, Kong Soo Khoo, Hean Chooi Ong, Nam Weng Sit
This study was conducted to investigate the antifungal potential and cytotoxicity of selected medicinal plants from Malaysia. The extracts from the stem of Cissus quadrangularis and the leaves of Asplenium nidus, Pereskia bleo, Persicaria odorata and Sauropus androgynus were assayed against six fungi using p-iodonitrotetrazolium-based on colorimetric broth microdilution method. All the plant extracts were found to be fungicidal against at least one type of fungus. The strongest fungicidal activity (minimum fungicidal concentration=0...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29347957/high-parasite-burden-increases-the-surfacing-and-mortality-of-the-manila-clam-ruditapes-philippinarum-in-intertidal-sandy-mudflats-on-the-west-coast-of-korea-during-hot-summer
#18
Ki-Woong Nam, Hee-Do Jeung, Jae-Hee Song, Kwan-Ha Park, Kwang-Sik Choi, Kyung-Il Park
BACKGROUND: Over the past few decades, mass mortality events of Manila clams have been reported from several tidal flats on the west coast of Korea during hot summers. During such mortality events, once clams simultaneously surface, they fail to re-burrow, perishing within a week. The present study aimed to identify the possible causes of the mass mortality of this clam species by investigating the Perkinsus olseni parasite burden and immune parameters of surfaced clams (SC) and normal buried clams (NBCs) when sea water or sediment temperature in the study area varied from 25 °C to 34 °C from late July through mid-August 2015...
January 18, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29346423/the-association-of-estimated-salt-intake-with-blood-pressure-in-a-viet-nam-national-survey
#19
Paul N Jensen, Tran Quoc Bao, Tran Thi Thanh Huong, Susan R Heckbert, Annette L Fitzpatrick, James P LoGerfo, Truong Le Van Ngoc, Ali H Mokdad
OBJECTIVE: To evaluate the association of salt consumption with blood pressure in Viet Nam, a developing country with a high level of salt consumption. DESIGN AND SETTING: Analysis of a nationally representative sample of Vietnamese adults 25-65 years of age who were surveyed using the World Health Organization STEPwise approach to Surveillance protocol. Participants who reported acute illness, pregnancy, or current use of antihypertensive medications were excluded...
2018: PloS One
https://www.readbyqxmd.com/read/29345050/metabolic-alterations-in-a-rat-model-of-hepatic-ischemia-reperfusion-injury-in-vivo-hyperpolarized-13-c-mrs-and-metabolic-imaging
#20
Chung-Man Moon, Sang-Soo Shin, Nam-Yeol Lim, Seul-Kee Kim, Yang-Joon Kang, Hyoung-Ook Kim, Seung-Jin Lee, Byung-Hyun Beak, Gwang-Woo Jeong
BACKGROUND & AIMS: Despite a number of studies addressing the pathophysiology of hepatic IRI, a gold standard test for early diagnosis and evaluation of IRI remains elusive. This study investigated the metabolic alterations in a rat model of hepatic IRI using the in vivo hyperpolarized ¹³C MRS and metabolic imaging. METHODS: Hyperpolarized 13 C MRS with IVIM-DWI were performed on the liver of seven sham-operated control rats, and seven rats before and after hepatic IRI...
January 18, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
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