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https://www.readbyqxmd.com/read/28334780/eif4a3-deficient-human-ipscs-and-mouse-models-demonstrate-neural-crest-defects-that-underlie-richieri-costa-pereira-syndrome
#1
Emily E Miller, Gerson S Kobayashi, Camila M Musso, Miranda Allen, Felipe A A Ishiy, Luiz C de Caires Junior, Ernesto S G Guimarães, Karina Griesi-Oliveira, Roseli M Zechi-Ceide, Antonio Richieri-Costa, Debora R Bertola, Maria Rita Passos-Bueno, Debra L Silver
Biallelic loss-of-function mutations in the RNA binding protein EIF4A3 cause Richieri-Costa-Pereira syndrome (RCPS), an autosomal recessive condition mainly characterized by craniofacial and limb malformations. However, the pathogenic cellular mechanisms responsible for this syndrome are entirely unknown. Here we used two complementary approaches, patient-derived induced pluripotent stem cells (iPSCs) and conditional Eif4a3 mouse models, to demonstrate that defective Neural Crest Cell (NCC) development explains RCPS craniofacial abnormalities...
March 2, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28328731/association-of-ipsilateral-rib-fractures-with-displacement-of-midshaft-clavicle-fractures
#2
Daniel Stahl, Matthew Ellington, Kindyle Brennan, Michael Brennan
OBJECTIVES: To determine whether the presence of ipsilateral rib fractures affects the rate of a clavicle fracture being unstable (>100% displacement). DESIGN: A retrospective review from 2002-2013 performed at a single level 1 trauma center evaluated 243 midshaft clavicle fractures. SETTING: Single Level 1 trauma center. PATIENTS/PARTICIPANTS: These fractures were subdivided into those with ipsilateral rib fractures (CIR; n = 149) and those without ipsilateral rib fractures (CnIR; n = 94)...
April 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28321570/comparative-analysis-of-locking-plate-versus-hook-plate-osteosynthesis-of-neer-type-iib-lateral-clavicle-fractures
#3
Benjamin Erdle, Kaywan Izadpanah, Martin Jaeger, Patrizia Jensen, Lukas Konstantinidis, Jörn Zwingmann, Norbert P Südkamp, Dirk Maier
INTRODUCTION: Controversy exists on optimal operative treatment of vertically unstable Neer IIB lateral clavicle fractures. Aim of this study was to analyse and compare clinical and radiological results and complications of locking plate osteosynthesis (LPO) versus hook plate osteosynthesis (HPO) with acromioclavicular joint (ACJ) stabilization. The hypothesis was, that HPO would recreate coracoclavicular stability more effectively and potentially lead to a superior outcome. METHODS: This retrospective, observational cohort study included 32 patients (19 HPO, 13 LPO) with a mean age of 44...
March 20, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28314896/end-cap-versus-no-end-cap-in-intramedullary-nailing-for-displaced-midshaft-clavicle-fractures-influence-on-implant-related-irritation
#4
H Frima, M H J Hulsmans, R M Houwert, U Ahmed Ali, E J M M Verleisdonk, C Sommer, M van Heijl
PURPOSE: Implant-related irritation at the entry site is a known disadvantage of intramedullary nailing for clavicle fractures. The purpose of this study was to compare implant-related irritation rates of intramedullary nailing with or without an end cap for displaced midshaft clavicle fractures. METHODS: Two cohorts of patients treated with intramedullary nailing with or without an end cap were matched and compared. Primary outcome was patient-reported implant-related irritation...
March 17, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28306578/selective-low-volume-nerve-block-for-the-open-surgical-fixation-of-a-midshaft-clavicle-fracture-in-a-conscious-high-risk-patient-a-case-report
#5
Carlos I Salvadores de Arzuaga, José M Naya Sieiro, Oscar Salmeron Zafra, Miguel A González Posada, Esther Marquez Martínez
We report a case of successful intraoperative management using only low-volume regional anesthesia for the open surgical fixation of a traumatic clavicle fracture in a conscious 69-year-old man with severe chronic obstructive pulmonary disease. To avoid general anesthesia, we provided low-volume C5 and C6 nerve root blocks along with a superficial cervical plexus block using only 9 mL of anesthetic solution to avoid the often encountered complications of higher volume injections. Throughout the procedure, the patient remained comfortable and cooperative with stable hemodynamics and respiration...
March 16, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28296812/pedicled-vascularized-clavicular-graft-for-anterior-cervical-arthrodesis-cadaveric-feasibility-study-technique-description-and-case-report
#6
Michael A Bohl, Michael A Mooney, Joshua S Catapano, Kaith K Almefty, Mark C Preul, Steve W Chang, U Kumar Kakarla, Edward M Reece, Jay D Turner, Randall W Porter
STUDY DESIGN: Cadaveric feasibility study. OBJECTIVES: To assess the anatomic and technical feasibility of rotating a clavicular segment on a sternocleidomastoid muscle (SCM) pedicle into the ventral cervical spine using a cadaveric model and to provide the first clinical case description of performing this procedure. SUMMARY OF BACKGROUND DATA: Reconstruction of the anterior cervical spine in patients with a high risk of pseudoarthrosis may require the use of a vascularized bone graft (VBG)...
March 14, 2017: Spine
https://www.readbyqxmd.com/read/28296289/congenital-anatomical-variant-of-the-clavicle
#7
Joan Viciano, Vincenzo Urbani, Ruggero D'Anastasio
The aim of this study is to present a rare abnormality of the clavicle (Code: SGS01) that was discovered in an ossuary in the Church of San Gaetano (Sulmona, central Italy; XVII-XIX centuries CE). In the middle third, the clavicle had three areas with losses of substance in the form of oval-shaped foramina with maximum diameters of 1-2 cm that were located in the anterior and superior surfaces of the diaphysis. The margins of these foramina were well defined and rounded, and the surfaces of the canal walls were smooth...
March 15, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28286623/effective-management-of-bone-fractures-with-the-illuminoss%C3%A2-photodynamic-bone-stabilization-system-initial-clinical-experience-from-the-european-union-registry
#8
Thomas Gausepohl, Dietmar Pennig, Steffen Heck, Sascha Gick, Paul A Vegt, Jon E Block
The IlluminOss(®) system (IS) uses a light-curable polymer contained within an inflatable balloon catheter, forming a patient customized intramedullary implant. A registry was established in Germany and The Netherlands to prospectively collect technical and clinical outcomes in patients treated with IS for fractures of the phalange, metacarpal, radius, ulna, distal radius, fibula, clavicle and/or olecranon. Humeral, femoral, tibial and pelvic fractures were included under compassionate use. Procedural success included successful placement of the device at the target fracture site and achievement of fracture stabilization...
February 20, 2017: Orthopedic Reviews
https://www.readbyqxmd.com/read/28282498/risk-factors-for-revision-surgery-after-superior-labral-anterior-posterior-repair
#9
Samuel A Taylor, Ryan M Degen, Alexander E White, Moira M McCarthy, Lawrence V Gulotta, Stephen J O'Brien, Brian C Werner
BACKGROUND: Data regarding risk factors for revision surgery after superior labral anterior-posterior (SLAP) repair are limited to institutional series. PURPOSE: To define risk factors for revision surgery after SLAP repair among patients in a large national database. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: A national insurance database was queried for patients undergoing arthroscopic SLAP repair (Current Procedural Terminology [CPT] code 29807) for the diagnosis of a SLAP tear...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28277467/high-energy-pediatric-scapula-fractures-and-their-associated-injuries
#10
Steven F Shannon, Nicholas M Hernandez, Stephen A Sems, Annalise N Larson, Todd A Milbrandt
OBJECTIVES: The purpose of this study was to evaluate pediatric scapula fractures occurring in high-energy motorized vehicle accidents and their associated injury patterns in a pediatric patient population. METHODS: One thousand nine hundred sixty-eight pediatric patients who presented after either on-road or off-road motorized vehicle accidents between 1996 and 2015 were retrospectively reviewed. Thirty-eight patients were found to have scapula fractures and the remaining 1930 were identified as controls...
March 8, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28276642/role-of-clavicle-chest-cage-angle-difference-in-predicting-postoperative-shoulder-balance-in-lenke-5c-adolescent-idiopathic-scoliosis-patients-after-selective-posterior-fusion
#11
Zhen Liu, Zong-Shan Hu, Yong Qiu, Zhen Zhang, Zhi-Hui Zhao, Xiao Han, Ze-Zhang Zhu
OBJECTIVE: To evaluate the role of preoperative clavicle chest cage angle difference (CCAD) on postoperative radiographic shoulder imbalance, patient's satisfaction and surgeon's fulfillment in Lenke 5 adolescent idiopathic scoliosis (AIS). CCAD, as a novel radiographic parameter, has proven to be a reliable predictor for postoperative shoulder imbalance in Lenke 1 AIS patients. However, the value of CCAD in predicting shoulder balance has never been evaluated in Lenke 5 AIS patients...
March 9, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28275882/management-of-chronic-unstable-acromioclavicular-joint-injuries
#12
REVIEW
Luis Natera Cisneros, Juan Sarasquete Reiriz
The acromioclavicular joint represents the link between the clavicle and the scapula, which is responsible for the synchronized dynamic of the shoulder girdle. Chronic acromioclavicular joint instability involves changes in the orientation of the scapula, which provokes cinematic alterations that might result in chronic pain. Several surgical strategies for the management of patients with chronic and symptomatic acromioclavicular joint instability have been described. The range of possibilities includes anatomical and non-anatomical techniques, open and arthroscopy-assisted procedures, and biological and synthetic grafts...
March 8, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28274008/to-operate-or-not-to-operate-the-mid-shaft-fractures-of-the-clavicle-a-comparative-study-of-functional-outcomes-of-the-two-methods-of-management
#13
Sanath Kumar Shetty, Ragesh Chandran, Arjun Ballal, Lawrence John Mathias, Anoop Hegde, Ashwin Shetty
INTRODUCTION: Fractures of the clavicle are some of the most common fractures which are seen in the adult population. Mid-shaft fractures of the clavicle are considered the most common form of clavicle fractures and about half of them are displaced fractures. They have been managed non-operatively over the years. However, severe displacement and comminution of these fractures have warranted the requirement of operative intervention, due to increased incidence of mal-union, worsening of shoulder functions etc...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28272336/development-of-portable-digital-radiography-system-with-a-device-for-monitoring-x-ray-source-detector-angle-and-its-application-in-chest-imaging
#14
Tae-Hoon Kim, Dong-Woon Heo, Chang-Won Jeong, Jong-Hyun Ryu, Hong Young Jun, Seung-Jun Han, Taeuk Ha, Kwon-Ha Yoon
This study developed a device measuring the X-ray source-detector angle (SDA) and evaluated the imaging performance for diagnosing chest images. The SDA device consisted of Arduino, an accelerometer and gyro sensor, and a Bluetooth module. The SDA values were compared with the values of a digital angle meter. The performance of the portable digital radiography (PDR) was evaluated using the signal-to-noise (SNR), contrast-to-noise ratio (CNR), spatial resolution, distortion and entrance surface dose (ESD). According to different angle degrees, five anatomical landmarks were assessed using a five-point scale...
March 7, 2017: Sensors
https://www.readbyqxmd.com/read/28271649/emphysematous-osteomyelitis-due-to-escherichia-coli
#15
Jinhee Lee, Chai Ho Jeong, Myun Hee Lee, Eun Gyo Jeong, Youn Jeong Kim, Sang Il Kim, Yang Ree Kim
Emphysematous osteomyelitis, especially that involving the extra-axial skeleton, is an extremely rare presentation but associated with significant morbidity and mortality. Here, we report a case in which a 58-year-old female patient with diabetes mellitus presented with emphysematous osteomyelitis that involved the sternum, clavicle, and pelvic bone and was caused by Escherichia coli via hematogenous spread of urinary tract infection. We successfully treated her with urgent and aggressive surgical drainage with prolonged antibiotics therapy...
February 7, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28263161/-secondary-dislocation-of-primarily-unnoticed-fracture-of-the-medial-clavicle
#16
Morten Kjerri Rasmussen, Rikke Thorninger
This is a case report of a 16-year-old boy with a bipolar fracture of the left clavicle. The patient crashed into a car on a moped with 40 mph. In the accident & emergency department (A&E) the patient was examined physically and by X-ray. There was no protruding bone or threatened skin. The X-ray showed a lateral clavicle fracture, but there were no clinical or radiological signs of medial fracture. The treatment was conservative. Three days later the patient was referred to A&E due to increasing pain and bone protruding of the medial clavicle...
March 6, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28256057/interrupted-bipartite-clavicle-as-a-diagnostic-clue-in-kabuki-syndrome
#17
Maria Haanpää, Helena Schlecht, Gauri Batra, Jill Clayton-Smith, Sofia Douzgou
Kabuki syndrome is a rare developmental disorder characterized by typical facial features, postnatal growth deficiency, mild to moderate intellectual disability, and minor skeletal anomalies. It is caused by mutations of the KMT2D and KDM6A genes while recently RAP1A and RAP1B mutations have been shown to rarely contribute to the pathogenesis. We report two patients' presentation of Kabuki syndrome caused by different KMT2D mutations, both including an interrupted/bipartite clavicle. The clinical diagnosis of Kabuki syndrome may be challenging, especially in younger patients and we suggest that the observation of a bipartite clavicle may be an additional diagnostic clue to prompt investigation for Kabuki syndrome...
March 3, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28229843/-flagrant-of-a-clavicle-fracture-as-bullfight-injury
#18
Carlos Durão, Jorge Ramos
The Vila Franca de Xira Hospital is located in the region with the highest number of festivals and bullfighting activities of Portugal. As a natural consequence, the hospital ends up with a particular experience in the treatment of victims of bullfighting accidents. These are usually common people harvested in street celebrations during the traditional festivals of the region, but also workers such as cattle herders, foremen, ranchers and others who handle the wild cattle and in particular those who deal with the bulls, such as forcados, banderilleros, matadors and cavaleiros...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28229229/management-of-unstable-distal-third-clavicle-fractures-clinical-and-radiological-outcomes-of-the-arthroscopy-assisted-conoid-ligament-reconstruction-and-fracture-cerclage-with-sutures
#19
Luis Natera Cisneros, Juan Sarasquete Reiriz
INTRODUCTION: Surgical treatment is indicated for the management of Neer type IIB fractures of the distal third of the clavicle. The aim of this study was to assess the clinical and radiological outcomes, in cases of unstable distal third clavicle fractures managed by means of an arthroscopy-assisted conoid ligament reconstruction and fracture cerclage with sutures. METHODS: Nine patients with unstable distal third clavicle fractures (Neer type IIB) managed arthroscopically by means of a conoid ligament reconstruction and fracture cerclage with sutures, between 2008 and 2012, were included...
February 22, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28219576/an-isolated-traumatic-medial-third-clavicular-fracture-requiring-surgical%C3%A2-fixation
#20
Jeremy Smelt, Raghbir Singh Khakha, Karen Harrison-Phipps, Andrew Richards, Andrea Bille
Fractures of the medial clavicle are rare injuries but are associated with significant morbidity and mortality. The current trend is shifting from conservative treatment to surgical intervention to reduce long-term sequelae. We present an isolated medial clavicular fracture associated with significant displacement and demonstrate excellent results after open reduction and internal fixation.
March 2017: Annals of Thoracic Surgery
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