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Capsaicin and obesity

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https://www.readbyqxmd.com/read/29797770/transient-receptor-potential-trp-channels-a-metabolic-tr-i-p-to-obesity-prevention-and-therapy
#1
REVIEW
M Bishnoi, P Khare, L Brown, S K Panchal
Cellular transport of ions, especially by ion channels, regulates physiological function. The transient receptor potential (TRP) channels, with 30 identified so far, are cation channels with high calcium permeability. These ion channels are present in metabolically active tissues including adipose tissue, liver, gastrointestinal tract, brain (hypothalamus), pancreas and skeletal muscle, which suggests a potential role in metabolic disorders including obesity. TRP channels have potentially important roles in adipogenesis, obesity development and its prevention and therapy because of their physiological properties including calcium permeability, thermosensation and taste perception, involvement in cell metabolic signalling and hormone release...
May 25, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29772784/capsaicin-in-metabolic-syndrome
#2
REVIEW
Sunil K Panchal, Edward Bliss, Lindsay Brown
Capsaicin, the major active constituent of chilli, is an agonist on transient receptor potential vanilloid channel 1 (TRPV1). TRPV1 is present on many metabolically active tissues, making it a potentially relevant target for metabolic interventions. Insulin resistance and obesity, being the major components of metabolic syndrome, increase the risk for the development of cardiovascular disease, type 2 diabetes, and non-alcoholic fatty liver disease. In vitro and pre-clinical studies have established the effectiveness of low-dose dietary capsaicin in attenuating metabolic disorders...
May 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29542131/identification-of-vanilloid-compounds-in-grains-of-paradise-and-their-effects-on-sympathetic-nerve-activity
#3
Hiroyuki Hattori, Kosei Yamauchi, Siaw Onwona-Agyeman, Tohru Mitsunaga
BACKGROUND: Grains of paradise (GP) is the seed of Aframomum melegueta, which is widely distributed throughout West Africa and has been used as a spice and a folk remedy for a long time. Anti-obesity effect of GP intake was demonstrated in a previous report. Aim of the present study was to isolate some compounds in GP and clarify the anti-obesity mechanism. RESULTS: Ten vanilloid compounds were isolated. Among them, 1-(4'-hydroxy-3'-methoxyphenyl)-decan-3-ol and 1-(4'-hydroxy-3'-methoxyphenyl)-3-octen-5-one were determined as novel compounds and 6-gingerol, 6-paradol and 6-shogaol were identified as the major constituents in GP extract...
March 15, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29530622/acute-administration-of-capsaicin-increases-resting-energy-expenditure-in-young-obese-subjects-without-affecting-energy-intake-appetite-and-circulating-levels-of-orexigenic-anorexigenic-peptides
#4
Antonello E Rigamonti, Claudia Casnici, Ornella Marelli, Alessandra De Col, Sofia Tamini, Elisa Lucchetti, Gabriella Tringali, Roberta De Micheli, Laura Abbruzzese, Mauro Bortolotti, Silvano G Cella, Alessandro Sartorio
Although capsaicin has been reported to reduce energy intake and increase energy expenditure in an adult (normal weight or overweight) population, thus resulting in a net negative energy balance and weight loss, these beneficial effects have not been investigated in young obese subjects. We hypothesize that capsaicin acutely administered in young obese subjects exerts the same effects on energy balance and that these effects are mediated by changes in gastrointestinal peptides regulating appetite. Thus, the aim of the present study was to evaluate the acute effects of capsaicin (2 mg) or placebo on energy intake, hunger, and satiety in obese adolescents and young adults (female-male ratio: 4:6, age: 21...
April 2018: Nutrition Research
https://www.readbyqxmd.com/read/29455258/effects-of-capsaicin-on-ovarian-granulosa-cell-proliferation-and-apoptosis
#5
Sabire Güler, Berrin Zik
Capsaicin is the pungent ingredient in red peppers. Due to the effects on the sensory nerve fibers, capsaicin has been used to treat pain and inflammation associated with a variety of diseases including rheumatoid arthritis and diabetic neuropathy, obesity, and cardiovascular and gastrointestinal conditions. Despite the extensive publications on different systems, the studies of the effects on the ovary are very limited. The present study was conducted to examine the possible proliferative and/or apoptotic effects of various doses of capsaicin on primarily derived granulosa cells...
February 17, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29362767/capsaicin-and-nonivamide-similarly-modulate-outcome-measures-of-mitochondrial-energy-metabolism-in-hepg2-and-3t3-l1-cells
#6
Christina M Hochkogler, Barbara Lieder, Daniel Schachner, Elke Heiss, Annett Schröter, Joachim Hans, Jakob P Ley, Gerhard E Krammer, Veronika Somoza
Capsaicin, the highly pungent principle of red pepper, has been demonstrated to have anti-obesity properties by affecting energy and lipid metabolism. Recent evidence from human intervention trials shows that also less pungent capsaicin analogs, like nonivamide, may help to reduce total body fat, although mechanistic data comparing the effects of capsaicin and nonivamide on outcome measures of energy metabolism are lacking. Here, the tissue-specific effects of capsaicin and nonivamide on parameters of mitochondrial energy metabolism in 3T3-L1 and HepG2 cells are investigated...
February 21, 2018: Food & Function
https://www.readbyqxmd.com/read/29356583/comparison-of-antiobesity-effects-between-gochujangs-produced-using-different-koji-products-and-tabasco-hot-sauce-in-rats-fed-a-high-fat-diet
#7
Hee-Kyoung Son, Hye-Won Shin, Eun-Seok Jang, Byoung-Seok Moon, Choong-Hwan Lee, Jae-Joon Lee
In this study, we compared the antiobesity effects between gochujangs prepared using different koji products and Tabasco hot sauce in rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were fed HFD containing four different types of 10% gochujang powder or 0.25% commercial Tabasco sauce powder for 8 weeks. The body weight gain, liver and epididymal and mesenteric fat pad weights, serum leptin levels, and lipogenesis-related mRNA levels of HFD-gochujang supplementation groups were significantly decreased compared with those of the HFD group...
March 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29280941/superoxide-anions-and-no-in-the-paraventricular-nucleus-modulate-the-cardiac-sympathetic-afferent-reflex-in-obese-rats
#8
Qing-Bo Lu, Jing Sun, Ying Kang, Hai-Jian Sun, Hui-Shan Wang, Yuan Wang, Guo-Qing Zhu, Ye-Bo Zhou
This study was conducted to explore the hypothesis that the endogenous superoxide anions (O₂- ) and nitric oxide (NO) system of the paraventricular nucleus (PVN) regulates the cardiac sympathetic afferent reflex (CSAR) contributing to sympathoexcitation in obese rats induced by a high-fat diet (42% kcal as fat) for 12 weeks. CSAR was evaluated by monitoring the changes of renal sympathetic nerve activity (RSNA) and the mean arterial pressure (MAP) responses to the epicardial application of capsaicin (CAP) in anaesthetized rats...
December 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29163755/uncoupling-protein-2-a-key-player-and-a-potential-therapeutic-target-in-vascular-diseases
#9
REVIEW
Giorgia Pierelli, Rosita Stanzione, Maurizio Forte, Serena Migliarino, Marika Perelli, Massimo Volpe, Speranza Rubattu
Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative stress accumulation. In the present article, we will review the evidence that UCP2, as a consequence of its roles within the mitochondria, represents a critical player in the predisposition to vascular disease development in both animal models and in humans, particularly in relation to obesity, diabetes, and hypertension...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28890700/dietary-capsaicin-improves-glucose-homeostasis-and-alters-the-gut-microbiota-in-obese-diabetic-ob-ob-mice
#10
Jun-Xian Song, Hui Ren, Yuan-Feng Gao, Chong-You Lee, Su-Fang Li, Feng Zhang, Long Li, Hong Chen
Background: The effects of capsaicin on obesity and glucose homeostasis are still controversial and the mechanisms underlying these effects remain largely unknown. This study aimed to investigate the potential relationship between the regulation of obesity and glucose homeostasis by dietary capsaicin and the alterations of gut microbiota in obese diabetic ob/ob mice. Methods: The ob/ob mice were subjected to a normal, low-capsaicin (0.01%), or high-capsaicin (0.02%) diet for 6 weeks, respectively. Obesity phenotypes, glucose homeostasis, the gut microbiota structure and composition, short-chain fatty acids, gastrointestinal hormones, and pro-inflammatory cytokines were measured...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28867743/effects-of-capsaicin-coadministered-with-eicosapentaenoic-acid-on-obesity-related-dysregulation-in-high-fat-fed-mice
#11
Yoshihiko Hirotani, Junta Fukamachi, Rina Ueyama, Yoko Urashima, Kenji Ikeda
Obesity-induced inflammation contributes to the development of metabolic disorders such as insulin resistance, type 2 diabetes, fatty liver disease, and cardiovascular disease. In this study, we investigated whether the combination of eicosapentaenoic acid (EPA) and capsaicin could protect against high-fat diet (HFD)-induced obesity and related metabolic disorders. The experiments were performed using male C57BL/6J mice that were fed one of the following diets for 10 weeks: standard chow (5.3% fat content) (normal group), a HFD (32...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28679750/erratum-for-kang-et-al-gut-microbiota-mediates-the-protective-effects-of-dietary-capsaicin-against-chronic-low-grade-inflammation-and-associated-obesity-induced-by-high-fat-diet
#12
Chao Kang, Bin Wang, Kanakaraju Kaliannan, Xiaolan Wang, Hedong Lang, Suocheng Hui, Li Huang, Yong Zhang, Ming Zhou, Mengting Chen, Mantian Mi
No abstract text is available yet for this article.
July 5, 2017: MBio
https://www.readbyqxmd.com/read/28659743/-in-vitro-inhibition-of-lipid-accumulation-induced-by-oleic-acid-and-in-vivo-pharmacokinetics-of-chitosan-microspheres-ctms-and-chitosan-capsaicin-microspheres-ccms
#13
Sihui Wu, Haitao Pan, Sirong Tan, Chen Ding, Guidong Huang, Guihua Liu, Jiao Guo, Zhengquan Su
Chitosan and capsaicin are compounds extracted from natural products and have been indicated to lower body weight and prevent fatty liver. However, their applications are limited by poor oral bioavailability, low compliance and some serious side effects. To solve these problems, we successfully prepared chitosan microspheres (CTMS) and chitosan-capsaicin microspheres (CCMS) in previous study. Therefore, in the present study, we evaluated the ability of CTMS and CCMS to eliminate lipid accumulation in hepatocytesand also characterized their pharmacokinetic parameters after administration...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28656459/involvement-of-thermosensitive-trp-channels-in-energy-metabolism
#14
REVIEW
Kunitoshi Uchida, Katsuya Dezaki, Takeshi Yoneshiro, Tatsuo Watanabe, Jun Yamazaki, Masayuki Saito, Toshihiko Yada, Makoto Tominaga, Yusaku Iwasaki
To date, 11 thermosensitive transient receptor potential (thermo-TRP) channels have been identified. Recent studies have characterized the mechanism of thermosensing by thermo-TRPs and the physiological role of thermo-TRPs in energy metabolism. In this review, we highlight the role of various thermo-TRPs in energy metabolism and hormone secretion. In the pancreas, TRPM2 and other TRPs regulate insulin secretion. TRPV2 expressed in brown adipocytes contributes to differentiation and/or thermogenesis. Sensory nerves that express TRPV1 promote increased energy expenditure by activating sympathetic nerves and adrenaline secretion...
September 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28536285/gut-microbiota-mediates-the-protective-effects-of-dietary-capsaicin-against-chronic-low-grade-inflammation-and-associated-obesity-induced-by-high-fat-diet
#15
Chao Kang, Bin Wang, Kanakaraju Kaliannan, Xiaolan Wang, Hedong Lang, Suocheng Hui, Li Huang, Yong Zhang, Ming Zhou, Mengting Chen, Mantian Mi
Metabolic endotoxemia originating from dysbiotic gut microbiota has been identified as a primary mediator for triggering the chronic low-grade inflammation (CLGI) responsible for the development of obesity. Capsaicin (CAP) is the major pungent bioactivator in chili peppers and has potent anti-obesity functions, yet the mechanisms linking this effect to gut microbiota remain obscure. Here we show that mice fed a high-fat diet (HFD) supplemented with CAP exhibit lower levels of metabolic endotoxemia and CLGI associated with lower body weight gain...
May 23, 2017: MBio
https://www.readbyqxmd.com/read/28507012/dietary-factors-promoting-brown-and-beige-fat-development-and-thermogenesis
#16
REVIEW
Meshail Okla, Jiyoung Kim, Karsten Koehler, Soonkyu Chung
Brown adipose tissue (BAT) is a specialized fat tissue that has a high capacity to dissociate cellular respiration from ATP utilization, resulting in the release of stored energy as heat. Adult humans possess a substantial amount of BAT in the form of constitutively active brown fat or inducible beige fat. BAT activity in humans is inversely correlated with adiposity, blood glucose concentrations, and insulin sensitivity; this suggests that strategies aimed at BAT-mediated bioenergetics are an attractive therapeutic target in combating the continuing epidemic of obesity and diabetes...
May 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28445156/dietary-capsaicin-and-antibiotics-act-synergistically-to-reduce-non-alcoholic-fatty-liver-disease-induced-by-high-fat-diet-in-mice
#17
Jingjuan Hu, Haihua Luo, Yong Jiang, Peng Chen
The prevalence of non-alcoholic fatty liver disease is increasing rapidly worldwide. However, effective strategies for combating high-fat diet (HFD) induced obesity, fatty liver and metabolic disorder are still limited, and outcomes remain poor. In the present study, we evaluated the combined actions of dietary capsaicin and antibiotics on HFD-induced physiological abnormalities in mice. C57BL/6 male mice were fed with HFD (60% calories from fat) for 17 weeks, and the resultant pathophysiological effects were examined...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28443906/the-enhanced-anti-obesity-effect-and-reduced-gastric-mucosa-irritation-of-capsaicin-loaded-nanoemulsions
#18
Muwen Lu, Yong Cao, Chi-Tang Ho, Qingrong Huang
Capsaicin (CAP), the major active component of chili peppers, is known to have thermogenic and weight-loss potential. The aim of this study was to investigate the anti-obesity effects of capsaicin-loaded nanoemulsions (C-NE) on male Sprague Dawley (SD) rats treated with a high-fat diet (HFD). The food grade C-NE was prepared using capsaicin, medium chain triacylglycerols (MCT) (Neobee 1053), sucrose stearate S-370, Tween 80 and distilled water with an emulsion droplet size of 168 nm and a capsaicin loading of 80...
May 24, 2017: Food & Function
https://www.readbyqxmd.com/read/28424369/dietary-capsaicin-and-its-anti-obesity-potency-from-mechanism-to-clinical-implications
#19
REVIEW
Jia Zheng, Sheng Zheng, Qianyun Feng, Qian Zhang, Xinhua Xiao
Obesity is a growing public health problem, which has now been considered as a pandemic non-communicable disease. However, the efficacy of several approaches for weight loss is limited and variable. Thus, alternative anti-obesity treatments are urgently warranted, which should be effective, safe, and widely available. Active compounds isolated from herbs are similar with the practice of Traditional Chinese Medicine, which has a holistic approach that can target to several organs and tissues in the whole body...
June 30, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28280490/anti-obesity-effect-of-capsaicin-in-mice-fed-with-high-fat-diet-is-associated-with-an-increase-in-population-of-the-gut-bacterium-akkermansia-muciniphila
#20
Wei Shen, Mengyu Shen, Xia Zhao, Hongbin Zhu, Yuhui Yang, Shuguang Lu, Yinling Tan, Gang Li, Ming Li, Jing Wang, Fuquan Hu, Shuai Le
Capsaicin (CAP) reduces body weight mainly through activation of transient receptor potential vanilloid 1 (TRPV1) cation channel. However, recent evidence indicates that the gut microbiota influences many physiological processes in host and might provoke obesity. This study determined whether the anti-obesity effect of CAP is related to the changes in gut microbiota. C57BL/6 mice were fed either with high-fat diet (HFD) or HFD with CAP (HFD-CAP) for 9 weeks. We observed a significantly reduced weight gain and improved glucose tolerance in HFD-CAP-fed mice compared with HFD-fed mice...
2017: Frontiers in Microbiology
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