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Capsaicin and obesity

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https://www.readbyqxmd.com/read/28163315/effects-of-topical-capsaicin-combined-with-moderate-exercise-on-insulin-resistance-body-weight-and-oxidative-stress-in-hypoestrogenic-obese-rats
#1
J M L Medina-Contreras, J Colado-Velázquez, N L Gómez-Viquez, P Mailloux-Salinas, I Perez-Torres, A Aranda-Fraustro, K Carvajal, G Bravo
BACKGROUND: Hypoestrogenic women are one of the most vulnerable groups for the development of obesity and its complications. Capsaicin and exercise have demonstrated to reduce body weight and to improve insulin sensitivity in different animal models, but it is unknown whether their combination could be useful in hypoestrogenic obese females. METHODS: We investigated whether topical capsaicin, exercise or their combination had better therapeutic effects in an obesity-hypoestrogenism model...
February 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28133727/diet-induced-obesity-enhances-trpv1-mediated-neurovascular-reactions-in-the-dura-mater
#2
Balázs Marics, Barna Peitl, Kitti Pázmándi, Attila Bácsi, József Németh, Orsolya Oszlács, Gábor Jancsó, Mária Dux
OBJECTIVE: Exploring the pathophysiological changes in transient receptor potential vanilloid 1 (TRPV1) receptor of the trigeminovascular system in high-fat, high-sucrose (HFHS) diet-induced obesity of experimental animals. BACKGROUND: Clinical and experimental observations suggest a link between obesity and migraine. Accumulating evidence indicates that metabolic and immunological alterations associated with obesity may potentially modulate trigeminovascular functions...
January 30, 2017: Headache
https://www.readbyqxmd.com/read/28104916/trpv1-activation-counters-diet-induced-obesity-through-sirtuin-1-activation-and-prdm-16-deacetylation-in-brown-adipose-tissue
#3
P Baskaran, V Krishnan, K Fettel, P Gao, Z Zhu, J Ren, B Thyagarajan
BACKGROUND/OBJECTIVE: An imbalance between energy intake and expenditure leads to obesity. Increasing metabolism and thermogenesis in brown adipose tissue (BAT) can help in overcoming obesity. Here, we investigated the effect of activation of transient receptor potential vanilloid subfamily 1 (TRPV1) in the upregulation of thermogenic proteins in BAT to counter diet-induced obesity. SUBJECTS/METHODS: We investigated the effect of dietary supplementation of capsaicin (CAP) (TRPV1 agonist) on the expression of metabolically important thermogenic proteins in BAT of wild-type and TRPV1(-/-) mice that received either a normal chow or high-fat (±CAP; TRPV1 activator) diet by immunoblotting...
February 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28099124/browning-of-white-adipose-tissue-lessons-from-experimental-models
#4
Thereza Cristina Lonzetti Bargut, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Beige or brite (brown-in-white) adipocytes are present in white adipose tissue (WAT) and have a white fat-like phenotype that when stimulated acquires a brown fat-like phenotype, leading to increased thermogenesis. This phenomenon is known as browning and is more likely to occur in subcutaneous fat depots. Browning involves the expression of many transcription factors, such as PR domain containing 16 (PRDM16) and peroxisome proliferator-activated receptor (PPAR)-γ, and of uncoupling protein (UCP)-1, which is the hallmark of thermogenesis...
January 18, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28012242/a-12-week-intervention-with-nonivamide-a-trpv1-agonist-prevents-a-dietary-induced-body-fat-gain-and-increases-peripheral-serotonin-in-moderately-overweight-subjects
#5
Christina M Hochkogler, Barbara Lieder, Petra Rust, David Berry, Samuel M Meier, Marc Pignitter, Alessandra Riva, Alina Leitinger, Anne Bruk, Simone Wagner, Joachim Hans, Sabine Widder, Jakob P Ley, Gerhard E Krammer, Veronika Somoza
SCOPE: A bolus administration of 0.15 mg nonivamide has previously been demonstrated to reduce energy intake in moderately overweight men. This 12-week intervention investigated whether a daily consumption of nonivamide in a protein-based product formulation promotes a reduction in body weight in healthy overweight subjects, and affects outcome measures associated with mechanisms regulating food intake, e.g. plasma concentrations of an-/orexigenic hormones, energy substrates as well as changes in fecal microbiota ...
December 24, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28001433/capsaicin-and-capsiate-could-be-appropriate-agents-for-treatment-of-obesity-a-meta-analysis-of-human-studies
#6
Csaba Zsiborás, Róbert Mátics, Péter Hegyi, Márta Balaskó, Erika Pétervári, Imre Szabó, Patrícia Sarlós, Alexandra Mikó, Judit Tenk, Ildikó Rostás, Dániel Pécsi, András Garami, Zoltán Rumbus, Orsolya Huszár, Margit Solymár
Consumption of capsaicin or its non-pungent analogues, capsinoids has been reported to affect energy expenditure and fat oxidation, although available data are still controversial. The aim of the present study was to conduct a meta-analysis regarding the effects of these substances on energy expenditure and respiratory quotient, with special emphasis on the role of body mass index (BMI) of the participants. Medical databases were systematically searched for papers. Of the 627 trials identified, 9 provided results suitable to be included in analysis...
December 21, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27899046/chili-pepper-as-a-body-weight-loss-food
#7
Sharon Varghese, Peter Kubatka, Luis Rodrigo, Katarina Gazdikova, Martin Caprnda, Julia Fedotova, Anthony Zulli, Peter Kruzliak, Dietrich Büsselberg
Chili has culinary as well as medical importance. Studies in humans, using a wide range of doses of chili intake (varying from a single meal to a continuous uptake for up to 12 weeks), concluded that it facilitates weight loss. In regard to this, the main targets of chili are fat metabolism, energy expenditure, and thermogenesis. To induce weight loss, the active substance of chili, capsaicin, activates Transient Receptor Potential Cation Channel sub-family V member 1 (TRPV1) channels) receptors causing an increase in intracellular calcium levels and triggering the sympathetic nervous system...
November 29, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27697214/activation-and-recruitment-of-brown-adipose-tissue-by-cold-exposure-and-food-ingredients-in-humans
#8
Masayuki Saito, Takeshi Yoneshiro, Mami Matsushita
Since the recent re-discovery of brown adipose tissue (BAT) in adult humans, this thermogenic tissue has attracted increasing interest. The inverse relationship between the BAT activity and body fatness suggests that BAT, because of its energy dissipating activity, is protective against body fat accumulation. Cold exposure activates and recruits BAT in association with increased energy expenditure and decreased body fatness. The stimulatory effects of cold are mediated through transient receptor potential channels (TRP), most of which are also chemesthetic receptors for various food ingredients...
August 2016: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/27694818/reduced-lipolysis-response-to-adipose-afferent-reflex-involved-in-impaired-activation-of-adrenoceptor-camp-pka-hormone-sensitive-lipase-pathway-in-obesity
#9
Lei Ding, Feng Zhang, Ming-Xia Zhao, Xing-Sheng Ren, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Chemical stimulation of white adipose tissue (WAT) causes adipose afferent reflex (AAR) and sympathetic activation. This study is to investigate the effects of AAR on lipolysis and the mechanisms of attenuated lipolysis response to enhanced AAR in obesity. Obesity was caused by high-fat diet for 12 weeks in rats. AAR was induced by injection of capsaicin into inguinal WAT or electrical stimulation of epididymal WAT afferent nerve. AAR caused sympathetic activation, which was enhanced in obesity rats. AAR increased cAMP levels and PKA activity, promoted hormone sensitive lipase (HSL) and perilipin phosphorylation, and increased lipolysis in WAT, which were attenuated in obesity rats...
October 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27455231/harnessing-the-therapeutic-potential-of-capsaicin-and-its-analogues-in-pain-and-other-diseases
#10
REVIEW
Shaherin Basith, Minghua Cui, Sunhye Hong, Sun Choi
Capsaicin is the most predominant and naturally occurring alkamide found in Capsicum fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been well characterized. The potential applications of capsaicin range from food flavorings to therapeutics. Indeed, capsaicin and few of its analogues have featured in clinical research covered by more than a thousand patents. Previous records suggest pleiotropic pharmacological activities of capsaicin such as an analgesic, anti-obesity, anti-pruritic, anti-inflammatory, anti-apoptotic, anti-cancer, anti-oxidant, and neuro-protective functions...
July 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27367653/capsaicin-current-understanding-of-its-mechanisms-and-therapy-of-pain-and-other-pre-clinical-and-clinical-uses
#11
REVIEW
Victor Fattori, Miriam S N Hohmann, Ana C Rossaneis, Felipe A Pinho-Ribeiro, Waldiceu A Verri
In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders...
June 28, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27328418/female-sex-and-obesity-increase-photophobic-behavior-in-mice
#12
Heather L Rossi, Orlando Lara, Ana Recober
Migraine affects predominantly women. Furthermore, epidemiological studies suggest that obesity is a risk factor for migraine and this association is influenced by sex. However, the biological basis for this bias is unclear. To address this issue, we assessed light avoidant behavior, a surrogate of photophobia, in female C57BL/6J mice fed regular diet (RD) or high-fat diet (HFD, 60% kcal from fat). We first assessed sex differences in basal photophobia in 20-25-week-old mice and found that both obese and lean females spent significantly less time in light than their male counterparts...
September 7, 2016: Neuroscience
https://www.readbyqxmd.com/read/27174467/capsaicin-induces-browning-of-white-adipose-tissue-and-counters-obesity-by-activating-trpv1-channel-dependent-mechanisms
#13
Padmamalini Baskaran, Vivek Krishnan, Jun Ren, Baskaran Thyagarajan
BACKGROUND AND PURPOSE: The growing epidemic of obesity and metabolic diseases necessitates the development of novel strategies to prevent and treat such diseases. Current research suggests that browning of white adipose tissue (WAT) promotes energy expenditure to counter obesity. Recent research suggests that activation of the TRPV1 channels counters obesity. However, the mechanism by which activation of TRPV1 channels counters obesity still remains unclear. EXPERIMENTAL APPROACH: We evaluated the effect of dietary capsaicin to induce a browning program in WAT by activating TRPV1 channels to prevent diet-induced obesity using wild-type and TRPV1(-/-) mouse models...
August 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27162380/anti-obesity-effects-of-gochujang-products-prepared-using-rice-koji-and-soybean-meju-in-rats
#14
H W Shin, E S Jang, B S Moon, J J Lee, D E Lee, C H Lee, C S Shin
The Korean traditional hot sauce gochujang has been reported to have biological activities. Different kinds of gochujang products were prepared based on combinations of a fungal rice koji with two kinds of bacterial soybean mejus. Diets that included gochujang products were fed to rats and anti-obesity effects were investigated. Gochujang products reduced body weight gains, epididymal fat weights, and triglyceride levels in the serum and the liver. Effects were exerted by the diet that included the non-fermented gochujang mixture, increased using a fungal rice koji, and further enhanced using a bacterial soybean meju...
February 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27120617/dietary-capsaicin-protects-cardiometabolic-organs-from-dysfunction
#15
REVIEW
Fang Sun, Shiqiang Xiong, Zhiming Zhu
Chili peppers have a long history of use for flavoring, coloring, and preserving food, as well as for medical purposes. The increased use of chili peppers in food is very popular worldwide. Capsaicin is the major pungent bioactivator in chili peppers. The beneficial effects of capsaicin on cardiovascular function and metabolic regulation have been validated in experimental and population studies. The receptor for capsaicin is called the transient receptor potential vanilloid subtype 1 (TRPV1). TRPV1 is ubiquitously distributed in the brain, sensory nerves, dorsal root ganglia, bladder, gut, and blood vessels...
April 25, 2016: Nutrients
https://www.readbyqxmd.com/read/27090808/an-investigation-of-the-neural-mechanisms-underlying-the-efficacy-of-the-adjustable-gastric-band
#16
Ph D Aneta Stefanidis, Neal Forrest, Wendy A Brown, John B Dixon, Paul B O'Brien, Juliane Kampe, Brian J Oldfield
BACKGROUND: The mechanisms via which adjustable gastric band (AGB) surgery provides effective and durable weight loss remain unclear. OBJECTIVES: This study defines the role of sensory vagal fibers in the efficacy of the adjustable gastric banding using capsaicin to eliminate unmyelinated afferent fibers in the vagus nerve in a rodent model. SETTING: University. METHODS: A miniaturized AGB was fitted at the gastroesophageal junction of obese rats with either intact or sensory fiber depleted vagus nerves where deafferentation involved intraperitoneal (125 mg/kg) or topical (1% to the stomach) application of capsaicin...
May 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27079706/the-associations-between-a-capsaicin-rich-diet-and-blood-amyloid-%C3%AE-levels-and-cognitive-function
#17
Cheng-Hui Liu, Xian-Le Bu, Jun Wang, Tao Zhang, Yang Xiang, Lin-Lin Shen, Qing-Hua Wang, Bo Deng, Xin Wang, Chi Zhu, Xiu-Qing Yao, Meng Zhang, Hua-Dong Zhou, Yan-Jiang Wang
BACKGROUND: Capsaicin-rich diets are common worldwide. Capsaicin has been shown to have favorable effects on various diseases including atherosclerosis, cardiovascular diseases, stroke, obesity, hypertension, cancer, and gastrointestinal and inflammatory diseases. The impact of capsaicin on Alzheimer's disease (AD), which is the most common form of dementia in the elderly, remains unknown. OBJECTIVE: To investigate the correlations of capsaicin intake with cognition and blood markers of AD...
April 8, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26963333/paraventricular-nucleus-is-involved-in-the-central-pathway-of-adipose-afferent-reflex-in-rats
#18
Zhen Shi, Yuan-Fang Wang, Gui-Hua Wang, Yu-Long Wu, Chun-Lei Ma
Increasing evidence indicates a link between sympathetic nervous system activation and obesity, but the underlying mechanisms remain elusive. The adipose afferent reflex (AAR) is a sympathoexcitatory reflex that is activated by afferent neurotransmission from the white adipose tissue (WAT). This study aimed to investigate whether the hypothalamic paraventricular nucleus (PVH) is an important component of the central neurocircuitry of the AAR. In anesthetized rats, the discharge activity of individual PVH neurons was recorded in vivo...
May 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/26945685/the-effects-of-capsaicin-and-capsaicinoid-analogs-on-metabolic-molecular-targets-in-highly-energetic-tissues-and-cell-types
#19
REVIEW
Nicholas P Gannon, Emily L Lambalot, Roger A Vaughan
There is increasing interest in dietary chemicals that may provide benefits for pathologies such as diabetes and obesity. Capsaicinoids found in chili peppers and pepper extracts, are responsible for the "hot" or "spicy" sensation associated with these foods. Capsaicinoid consumption is also associated with enhanced metabolism, making them potentially therapeutic for metabolic disease by promoting weight loss. This review summarizes much of the current experimental evidence (ranging from basic to applied investigations) of the biochemical and molecular metabolic effects of capsaicinoids in metabolically significant cell types...
May 2016: BioFactors
https://www.readbyqxmd.com/read/26936964/a-synergistic-antiobesity-effect-by-a-combination-of-capsinoids-and-cold-temperature-through-promoting-beige-adipocyte-biogenesis
#20
Kana Ohyama, Yoshihito Nogusa, Kosaku Shinoda, Katsuya Suzuki, Makoto Bannai, Shingo Kajimura
Beige adipocytes emerge postnatally within the white adipose tissue in response to certain environmental cues, such as chronic cold exposure. Because of its highly recruitable nature and relevance to adult humans, beige adipocytes have gained much attention as an attractive cellular target for antiobesity therapy. However, molecular circuits that preferentially promote beige adipocyte biogenesis remain poorly understood. We report that a combination of mild cold exposure at 17°C and capsinoids, a nonpungent analog of capsaicin, synergistically and preferentially promotes beige adipocyte biogenesis and ameliorates diet-induced obesity...
May 2016: Diabetes
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