keyword
https://read.qxmd.com/read/38531438/capsaicin-induces-atp-dependent-thermogenesis-via-the-activation-of-trpv1-%C3%AE-3-ar-%C3%AE-1-ar-in-3t3-l1-adipocytes-and-mouse-model
#1
JOURNAL ARTICLE
Abdillah Alfin Mohammad, Jong Won Yun
Capsaicin (CAP) is a natural bioactive compound in chili pepper that activates the transient receptor potential vanilloid subfamily 1 (TRPV1) and is known to stimulate uncoupling protein 1 (UCP1)-dependent thermogenesis. However, its effect on ATP-dependent thermogenesis remains unknown. In this study, we employed qRT-PCR, immunoblot, staining method, and assay kit to investigate the role of CAP on ATP-dependent thermogenesis and its modulatory roles on the TRPV1, β3-adrenergic receptor (β3-AR), and α1-AR using in vitro and in vivo models...
March 24, 2024: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/38531262/trpv1-receptor-structure-activation-modulation-and-role-in-neuro-immune-interactions-and-pain
#2
REVIEW
Thaila Kawane Euflazio Maximiano, Jessica Aparecida Carneiro, Victor Fattori, Waldiceu A Verri
In the 1990s, the identification of a non-selective ion channel, especially responsive to capsaicin, revolutionized the studies of somatosensation and pain that were to follow. The TRPV1 channel is expressed mainly in neuronal cells, more specifically, in sensory neurons responsible for the perception of noxious stimuli. However, its presence has also been detected in other non-neuronal cells, such as immune cells, β- pancreatic cells, muscle cells and adipocytes. Activation of the channel occurs in response to a wide range of stimuli, such as noxious heat, low pH, gasses, toxins, endocannabinoids, lipid-derived endovanilloid, and chemical agents, such as capsaicin and resiniferatoxin...
March 8, 2024: Cell Calcium
https://read.qxmd.com/read/38524547/potential-actions-of-capsaicin-for-preventing-vascular-calcification-of-vascular-smooth-muscle-cells-in-vitro-and-in-vivo
#3
JOURNAL ARTICLE
Yin-Fang Yan, Yue Feng, Si-Min Wang, Fei Fang, Hong-Yan Chen, Ming-Xia Zhen, Yu-Qiang Ji, Song-Di Wu
Vascular calcification (VC) is an accurate risk factor and predictor of adverse cardiovascular events; however, there is currently no effective therapy to specifically prevent VC progression. Capsaicin (Cap) is a bioactive alkaloid isolated from Capsicum annuum L., a traditional medicinal and edible plant that is beneficial for preventing cardiovascular diseases. However, the effect of Cap on VC remains unclear. This study aimed to explore the effects and related mechanisms of Cap on aortic calcification in a mouse and on Pi-induced calcification in vascular smooth muscle cells (VSMCs)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38508837/dysphagia-after-stroke-research-advances-in-treatment-interventions
#4
REVIEW
Bendix Labeit, Emilia Michou, Michaela Trapl-Grundschober, Sonja Suntrup-Krueger, Paul Muhle, Philip M Bath, Rainer Dziewas
After a stroke, most patients have dysphagia, which can lead to aspiration pneumonia, malnutrition, and adverse functional outcomes. Protective interventions aimed at reducing these complications remain the cornerstone of treatment. Dietary adjustments and oral hygiene help mitigate the risk of aspiration pneumonia, and nutritional supplementation, including tube feeding, might be needed to prevent malnutrition. Rehabilitative interventions aim to enhance swallowing function, with different behavioural strategies showing promise in small studies...
April 2024: Lancet Neurology
https://read.qxmd.com/read/38508727/transient-receptor-potential-vanilloid-1-interacts-with-tlr4-cd14-signaling-pathway-in-lipopolysaccharide-mediated-inflammation-in-macrophages
#5
JOURNAL ARTICLE
Julia Chu-Ning Hsu, Hsu-Wen Tseng, Chia-Hui Chen, Tzong-Shyuan Lee
Transient receptor potential vanilloid 1 (TRPV1), a ligand-gated cation channel, is a receptor for vanilloids on sensory neurons and is also activated by capsaicin, heat, protons, arachidonic acid metabolites, and inflammatory mediators on neuronal or non-neuronal cells. However, the role of the TRPV1 receptor in pro-inflammatory cytokine secretion and its potential regulatory mechanisms in lipopolysaccharide (LPS)-induced inflammation has yet to be entirely understood. To investigate the role and regulatory mechanism of the TRPV1 receptor in regulating LPS-induced inflammatory responses, bone marrow-derived macrophages (BMDMs) harvested from wild-type (WT) and TRPV1 deficient (Trpv1-/- ) mice were used as the cell model...
March 21, 2024: Experimental Animals
https://read.qxmd.com/read/38505500/update-on-treating-painful-diabetic-peripheral-neuropathy-a-review-of-current-us-guidelines-with-a-focus-on-the-most-recently-approved-management-options
#6
REVIEW
Theresa Mallick-Searle, Jeremy A Adler
Painful diabetic peripheral neuropathy (DPN) is a highly prevalent and disabling complication of diabetes that is often misdiagnosed and undertreated. The management of painful DPN involves treating its underlying cause via lifestyle modifications and intensive glucose control, targeting its pathogenesis, and providing symptomatic pain relief, thereby improving patient function and health-related quality of life. Four pharmacologic options are currently approved by the US Food and Drug Administration (FDA) to treat painful DPN...
2024: Journal of Pain Research
https://read.qxmd.com/read/38501987/the-influence-of-pain-and-kinesiophobia-on-motor-control-of-the-upper-limb-how-pointing-task-paradigms-can-point-to-new-avenues-of-understanding
#7
JOURNAL ARTICLE
Arnaud Duport, Pierre Morel, Guillaume Léonard, Hervé Devanne
People experiencing kinesiophobia are more likely to develop persistent disabilities and chronic pain. However, the impact of kinesiophobia on the motor system remains poorly understood. We investigated whether kinesiophobia could modulate shoulder pain-induced changes in (1) kinematic parameters and muscle activation during functional movement and (2) corticospinal excitability. Thirty healthy, pain-free subjects took part in the study. Shoulder, elbow, and finger kinematics, as well as electromyographic activity of the upper trapezius and anterior deltoid muscles, were recorded while subjects performed a pointing task before and during pain induced by capsaicin at the shoulder...
March 13, 2024: Pain
https://read.qxmd.com/read/38501280/design-synthesis-and-functional-validation-of-peptide-inhibitors-based-on-trpv1-ion-channel-agonist-rhtx
#8
JOURNAL ARTICLE
Heng Zhang, Jiawei Wang, Fan Yang
OBJECTIVES: To design and synthesize peptide inhibitors based on transient receptor potential vanilloid 1 (TRPV1) ion channel agonist red head toxin (RhTx), and to validate their function. METHODS: Based on previous studies on the relation of molecular structure and function of RhTx, a series of peptides were rationally designed and synthesized, with positive charged amino acids linked to the N terminus of RhTx. These Nplus-RhTx peptides were functionally validated by patch-clamp recordings in live cells...
March 19, 2024: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://read.qxmd.com/read/38499507/silver-nanoparticles-stimulate-5-fluorouracil-induced-colorectal-cancer-cells-to-kill-through-the-upregulation-trpv1-mediated-calcium-signaling-pathways
#9
JOURNAL ARTICLE
Müge Mavioğlu Kaya
The involvement of the TRP vanilloid 1 (TRPV1) cation channel on the 5-Fluorouracil (5-FU)-caused Ca2+ signals through the activation of the apoptotic signaling pathway and stimulating the mitochondrial Ca2+ and Zn2+ accumulation-induced reactive oxygen species (ROS) productions in several cancer cells, except the colorectal cancer (HT-29) cell line, was recently reported. I aimed to investigate the action of silver nanoparticles (SiNPs) and 5-FU incubations through the activation of TRPV1 on ROS, apoptosis, and cell death in the HT-29 cell line...
March 18, 2024: Cell Biology International
https://read.qxmd.com/read/38498503/synergistic-influence-of-arbuscular-mycorrhizal-fungi-inoculation-with-nanoparticle-foliar-application-enhances-chili-capsicum-annuum-l-antioxidant-enzymes-anatomical-characteristics-and-productivity-under-cold-stress-conditions
#10
JOURNAL ARTICLE
Eman G Sayed, S F Desoukey, Abeer F Desouky, Mervat F Farag, Ragab I El-Kholy, Samah N Azoz
In this study, we aimed to evaluate the effects of Arbuscular mycorrhiza fungus (AMF) inoculation, foliar application of zinc oxide and selenium nanoparticles (ZnO-NPs and Se-NPs), and their combined interactions on the growth and productivity of chili pepper under cold-stress conditions. Two field experiments were successfully conducted during the winter seasons of 2021 and 2022 in an experimental field at the Faculty of Agriculture, Cairo University, Giza, Egypt. The results showed that, under cold stress, the combination of AMF inoculation and ZnO-NPs + Se-NPs as a foliar spray increased the average fruit weight by 92...
February 14, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38497888/unveiling-the-antinociceptive-mechanisms-of-methyl-2-4-chloro-phenyl-5-benzoxazoleacetate-insights-from-nociceptive-assays-in-mice
#11
JOURNAL ARTICLE
Q Jarrar, R Ayoub, Y Jarrar, H Jaffal, K W Goh, L C Ming, S Moshawih, A Sirhan
OBJECTIVE: Methyl-2-(4-chloro- phenyl)-5-benzoxazoleacetate (MCBA), a synthetic benzoxazole derivative with established antipsoriatic efficacy, was investigated for potential antinociceptive effects. This study employs various nociceptive assays in mice to elucidate MCBA's antinociceptive mechanisms. MATERIALS AND METHODS: MCBA's antinociceptive potential was tested against various nociception models induced by formalin, glutamate, capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor agonist, and phorbol 12-myristate 13-acetate, a protein kinase C (PKC) activator...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497128/stimulatory-effect-of-methylglyoxal-on-capsaicin-sensitive-lung-vagal-afferents-in-rats-role-of-trpa1
#12
JOURNAL ARTICLE
You Shuei Lin, Nai-Ju Chan, Pei-Yu Xiao, Ching Jung Lai
Methylglyoxal (MG), a reactive metabolic byproduct of glycolysis, is a causative of painful diabetic neuropathy. Patients with diabetes are associated with more frequent severe asthma exacerbation. Stimulation of capsaicin-sensitive lung vagal (CSLV) afferents may contribute to the pathogenesis of hyperreactive airway diseases such as asthma. However, the possibility of the stimulatory effect of MG on CSLV afferents and the underlying mechanisms remain unknown. Our results showed that intravenous injection of MG (25 mg/kg, MG25) in anesthetized, spontaneously breathing rats elicited pulmonary chemoreflexes characterized by apnea, bradycardia, and hypotension...
March 18, 2024: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://read.qxmd.com/read/38495092/evaluation-of-binding-mechanism-of-dietary-phytochemical-capsaicin-with-human-transferrin-targeting-neurodegenerative-diseases-therapeutics
#13
JOURNAL ARTICLE
Mohammed Alrouji, Fahad A Alhumaydhi, Kumar Venkatesan, Sharaf E Sharaf, Moyad Shahwan, Anas Shamsi
Human transferrin (htf) plays a crucial role in regulating the balance of iron within brain cells; any disruption directly contributes to the development of Neurodegenerative Diseases (NDs) and other related pathologies, especially Alzheimer's Disease (AD). In recent times, a transition towards natural compounds is evident to treat diseases and this shift is mainly attributed to their broad therapeutic potential along with minimal side effects. Capsaicin, a natural compound abundantly found in red and chili peppers, possess neuroprotective potential...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38488908/clinical-insights-into-traumatic-injury-of-the-inferior-alveolar-and-lingual-nerves-a-comprehensive-approach-from-diagnosis-to-therapeutic-interventions
#14
REVIEW
Peer W Kämmerer, Diana Heimes, Amely Hartmann, Marco Kesting, Fouad Khoury, Eik Schiegnitz, Daniel G E Thiem, Jörg Wiltfang, Bilal Al-Nawas, Wolfgang Kämmerer
OBJECTIVES: This scoping review explores the risk and management of traumatic injuries to the inferior alveolar and lingual nerves during mandibular dental procedures. Emphasizing the significance of diagnostic tools, the review amalgamates existing knowledge to offer a comprehensive overview. MATERIALS AND METHODS: A literature search across PubMed, Embase, and Cochrane Library informed the analysis. RESULTS: Traumatic injuries often lead to hypo-/anesthesia and neuropathic pain, impacting individuals psychologically and socially...
March 15, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38481548/phytoformulation-with-hydroxycitric-acid-and-capsaicin-protects-against-high-fat-diet-induced-obesity-cardiomyopathy-by-reducing-cardiac-lipid-deposition-and-ameliorating-inflammation-and-apoptosis-in-the-heart
#15
JOURNAL ARTICLE
V V Sathibabu Uddandrao, P Chandrasekaran, G Saravanan, Parim Brahmanaidu, S Sengottuvelu, P Ponmurugan, S Vadivukkarasi, Umesh Kumar
BACKGROUND AND AIM: Phytoformulation therapy is a pioneering strategy for the treatment of metabolic disorders and related diseases. The aim of the present study was to investigate the protective effect of a phytoformulation consisting of hydroxycitric acid and capsaicin against obesity-related cardiomyopathy. EXPERIMENTAL PROCEDURE: Sprague-Dawley rats were fed HFD for 21 weeks, and phytoformulation (100 mg/kg body weight) was administered orally for 45 days starting at week 16...
March 2024: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/38481530/cyclodextrin-derivatives-decrease-transient-receptor-potential-vanilloid-1-and-ankyrin-1-ion-channel-activation-via-altering-the-surrounding-membrane-microenvironment-by-cholesterol-depletion
#16
JOURNAL ARTICLE
Andrea Kinga Nehr-Majoros, János Erostyák, Éva Fenyvesi, Edina Szabó-Meleg, Levente Szőcs, György Sétáló, Zsuzsanna Helyes, Éva Szőke
Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) are nonselective cation channels expressed in primary sensory neurons and several other non-neuronal structures such as immune cells, keratinocytes, and vascular smooth muscle cells. They play important roles in nociception, pain processing and their chanellopathies are associated with the development of several pathological conditions. They are located in cholesterol- and sphingolipid-rich membrane lipid raft regions serving as platforms to modulate their activations...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38478397/attenuation-of-colitis-induced-visceral-hypersensitivity-and-pain-by-selective-silencing-of-trpv1-expressing-fibers-in-rat-colon
#17
JOURNAL ARTICLE
Yoav Mazor, Nurit Engelmayer, Halla Nashashibi, Lisa Rottenfußer, Shaya Lev, Alexander M Binshtok
BACKGROUND: Transient receptor potential vanilloid 1 (TRPV1) cation channels, expressed on nociceptors, are well established as key contributors to abdominal pain in inflammatory bowel disease (IBD). Previous attempts at blocking these channels have been riddled with side effects. Here, we propose a novel treatment strategy, utilizing the large pore of TRPV1 channels as a drug delivery system to selectively inhibit visceral nociceptors. METHODS: We induced colitis in rats using intrarectal dinitrobenzene sulfonic acid...
March 13, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38476205/uhplc-qtof-ms-based-nontargeted-metabolomics-to-characterize-the-effects-of-capsaicin-on-plasma-and-skin-metabolic-profiles-of-c57bl-6-mice-an-in-vivo-experimental-study
#18
JOURNAL ARTICLE
Zhen Xiao, Simin Yu, Deng Zhang, Chunming Li
BACKGROUND: Capsaicin is the main compound found in chili pepper and has complex pharmacologic effects. This study aimed to elucidate the mechanism of the effect of capsaicin on physiological processes by analyzing changes in metabolites and metabolic pathways. METHODS: Female C57BL/6 mice were divided into two groups(n = 10/group) and fed with capsaicin-soybean oil solution(group T) or soybean oil(group C) for 6 weeks. Ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC-qTOF-MS) based metabolomics was undertaken to assess plasma and skin metabolic profile changes and identify differential metabolites through multivariate analysis...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38474005/intrinsic-lipid-curvature-and-bilayer-elasticity-as-regulators-of-channel-function-a-comparative-single-molecule-study
#19
JOURNAL ARTICLE
Mohammad Ashrafuzzaman, Roger E Koeppe, Olaf S Andersen
Perturbations in bilayer material properties (thickness, lipid intrinsic curvature and elastic moduli) modulate the free energy difference between different membrane protein conformations, thereby leading to changes in the conformational preferences of bilayer-spanning proteins. To further explore the relative importance of curvature and elasticity in determining the changes in bilayer properties that underlie the modulation of channel function, we investigated how the micelle-forming amphiphiles Triton X-100, reduced Triton X-100 and the HII lipid phase promoter capsaicin modulate the function of alamethicin and gramicidin channels...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38471384/targeting-trp-channels-for-pain-relief-a-review-of-current-evidence-from-bench-to-bedside
#20
REVIEW
Ari-Pekka Koivisto, Thomas Voets, Michael J Iadarola, Arpad Szallasi
Several decades of research support the involvement of transient receptor potential (TRP) channels in nociception. Despite the disappointments of early TRPV1 antagonist programs, the TRP family remains a promising therapeutic target in pain disorders. High-dose capsaicin patches are already in clinical use to relieve neuropathic pain. At present, localized injections of the side-directed TRPV1 agonist capsaicin and resiniferatoxin are undergoing clinical trials in patients with osteoarthritis and bone cancer pain...
April 2024: Current Opinion in Pharmacology
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