Harm Jan van der Horn, Andrei A Vakhtin, Kayla Julio, Stephanie Nitschke, Nicholas Shaff, Andrew B Dodd, Erik Erhardt, John P Phillips, Sarah Pirio Richardson, Amanda Deligtisch, Melanie Stewart, Gerson Suarez Cedeno, Sanne K Meles, Andrew R Mayer, Sephira G Ryman
A mounting body of research points to cerebrovascular dysfunction as a fundamental element in the pathophysiology of Parkinson's disease (PD). In the current feasibility study, blood-oxygen-level-dependent (BOLD) MRI was used to measure cerebrovascular reactivity (CVR) in response to hypercapnia in 26 PD patients and 16 healthy controls (HC), and aimed to find a multivariate pattern specific to PD. Whole-brain maps of CVR amplitude (i.e., magnitude of response to CO2 ) and latency (i.e., time to reach maximum amplitude) were computed, which were further analyzed using scaled sub-profile model principal component analysis (SSM-PCA) with leave-one-out cross-validation...
April 5, 2024: Journal of Cerebral Blood Flow and Metabolism