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https://www.readbyqxmd.com/read/29471001/activated-cxcl5-cxcr2-axis-promotes-the-migration-invasion-and-emt-of-papillary-thyroid-carcinoma-cells-via-modulation-of-%C3%AE-catenin-pathway
#1
Dong Cui, Yongfu Zhao, Jingchao Xu
Initiation of epithelial-to-mesenchymal transition (EMT) is common in papillary thyroid carcinoma (PTC) and may contribute to its metastasis. Aims of the present study are to investigate whether and how the C-X-C motif chemokine ligand (CXCL)-5/C-X-C motif receptor 2 (CXCR2) axis affects PTC metastasis, with a focus on the EMT process. Herein, two PTC cell lines, KTC-1 and B-CPAP cells, identified as CXCR2-positive cells were used as the cell model. We found that a 24-h stimulation of 1 or 10 nM recombinant human CXCL5 (rhCXCL5) enhanced the migration and invasion of both KTC-1 and B-CPAP cells without affecting their proliferation...
February 19, 2018: Biochimie
https://www.readbyqxmd.com/read/29470983/development-of-a-functional-thyroid-model-based-on-an-organoid-culture-system
#2
Yoshiyuki Saito, Nobuyuki Onishi, Hiroshi Takami, Ryo Seishima, Hiroyoshi Inoue, Yuki Hirata, Kaori Kameyama, Kenji Tsuchihashi, Eiji Sugihara, Shinya Uchino, Koichi Ito, Hirofumi Kawakubo, Hiroya Takeuchi, Yuko Kitagawa, Hideyuki Saya, Osamu Nagano
The low turnover rate of thyroid follicular cells and the lack of a long-term thyroid cell culture system have hampered studies of thyroid carcinogenesis. We have now established a thyroid organoid culture system that supports thyroid cell proliferation in vitro. The established mouse thyroid organoids performed thyroid functions including thyroglobulin synthesis, iodide uptake, and the production and release of thyroid hormone. Furthermore, transplantation of the organoids into recipient mice resulted in the formation of normal thyroid-like tissue capable of iodide uptake and thyroglobulin production in vivo...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29470956/metabolomic-insights-into-the-effects-of-thyroid-hormone-on-rana-lithobates-catesbeiana-metamorphosis-using-whole-body-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging-maldi-msi
#3
Teesha C Luehr, Emily M Koide, Xiaodong Wang, Jun Han, Christoph H Borchers, Caren C Helbing
Anuran metamorphosis involves the transformation of an aquatic tadpole into a juvenile frog. This process is completely dependent upon thyroid hormones (THs). Although much research has been focused on changes in gene expression programs during this postembryonic developmental period, transitions in the metabolic profiles are relatively poorly understood. Matrix Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging (MALDI-MSI) is a technique that generates highly multiplexed mass spectra while retaining spatial location information on a thin tissue section...
February 19, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29470826/small-papillary-thyroid-carcinoma-with-minimal-extrathyroidal-extension-should-be-managed-as-ata-low-risk-tumor
#4
M G Castagna, R Forleo, F Maino, N Fralassi, F Barbato, P Palmitesta, T Pilli, M Capezzone, L Brilli, C Ciuoli, S Cantara, C Formichi, F Pacini
PURPOSE: According to American Thyroid Association (ATA) guideline, papillary thyroid cancer (PTC) with minimal extrathyroidal extension (mETE) is classified at "intermediate risk" of persistent/recurrent disease. However, the impact of mETE per se on patients' outcome is not fully understood. The aim of our study was to evaluate the prognostic significance of mETE in patients with PTC not submitted to therapeutic or prophylactic lymph node dissection, according to tumor size and other prognostic factors...
February 22, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29470700/incidental-diagnosis-of-parathyroid-lesions-by-preoperative-use-of-next-generation-molecular-testing
#5
Wu Bo, Karen E Schoedel, Sally E Carty, Lisa A Radkay, N Paul Ohori, Yuri E Nikiforov, Marina N Nikiforova, Linwah Yip
BACKGROUND: Parathyroid glands can mimic thyroid follicular lesions on fine-needle aspiration (FNA) cytology and can lead to unnecessary or incorrect surgery. Newer molecular panel tests using next-generation sequencing (NGS) include analysis of cell type-specific gene expression profiles such as parathyroid. The study aim is to determine the frequency and clinical implications of parathyroid tissue identification by molecular testing in cytologically indeterminate "thyroid" lesions...
February 22, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29470699/a-nested-case-control-study-on-the-risk-of-surgical-site-infection-after-thyroid-surgery
#6
F A Salem, M Almquist, E Nordenström, J Dahlberg, O Hessman, C I Lundgren, A Bergenfelz
INTRODUCTION: It is unclear if antibiotic prophylaxis reduces the risk of surgical site infection (SSI) in thyroid surgery. This study assessed risk factors for SSI and antibiotic prophylaxis in subgroups of patients. METHOD AND DESIGN: A nested case-control study on patients registered in the Swedish National Register for Endocrine Surgery was performed. Patients with SSI were matched 1:1 by age and gender to controls. Additional information on patients with SSI and controls was queried from attending surgeons using a questionnaire...
February 22, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29470698/permanent-hypoparathyroidism-after-total-thyroidectomy-in-children-results-from-a-national-registry
#7
Erik Nordenström, Anders Bergenfelz, Martin Almquist
INTRODUCTION: Hypoparathyroidism is the most common complication following thyroidectomy. There are few population-based reports on the rate of hypoparathyroidism in children. The incidence of medical treatment of permanent hypoparathyroidism in children is reported using a national registry. METHODS: The study population included patients below 18 years of age undergoing total thyroidectomy reported to the Scandinavian Quality Registry for Thyroid, Parathyroid and Adrenal Surgery 2004-2014...
February 22, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29470574/changes-in-scope-of-procedures-performed-by-pediatric-otolaryngologists-in-the-past-decade
#8
Alexandria L Irace, Catherine Shank, Eelam A Adil, Michael J Cunningham, Kosuke Kawai, Georgios Sideridis, Reza Rahbar
Importance: Monitoring current trends in pediatric otolaryngology will help adjust our training and practice paradigms in a way that ensures the long-term viability of the specialty. Objectives: To gauge the current scope of pediatric otolaryngology (ORL) practice within and outside of the United States and to identify changes in caseload over the past decade. Design, Setting, and Participants: An online survey was sent to pediatric ORL chairs and/or fellowship directors at 42 institutions in the United States and abroad...
February 22, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29470378/preanesthesia-concerns-in-a-patient-with-a-thyroid-mass
#9
Gayle B Bodner, Ashley L Talbott
Preoperative evaluation helps identify patient comorbidities and surgical characteristics that increase perioperative risk, and also can help identify patients with potentially difficult airways. Identifying patients with difficult airways before surgery lets clinicians plan appropriate perioperative management and prepare for potential complications. This article focuses on management of a difficult airway in a patient undergoing surgery for a thyroid mass.
March 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29469959/oncogenic-mutations-in-keap1-disturbing-inhibitory-nrf2-keap1-interaction-activation-of-antioxidative-pathway-in-papillary-thyroid-carcinoma
#10
Debora Lucia Seguro Danilovic, Evandro Sobroza de Mello, Eliana Salgado Turri Frazzato, Alda Wakamatsu, Alexander Augusto de Lima Jorge, Ana Oliveira Hoff, Suemi Marui
BACKGROUND: Nuclear factor erythroid 2-like 2 (NFE2L2) encodes Nrf2, transcription factor of antioxidative genes. In the presence of reactive oxygen species, Keap1 (Kelch-ECH-associating protein-1) inhibitor complex undergoes conformational changes disrupting Keap1-Nrf2 binding and Nrf2 translocates into nucleus. We evaluated the presence of mutations in NFE2L2 and KEAP1 in papillary thyroid carcinomas (PTCs) and correlated them with clinical presentation. METHODS: Coding regions of NFE2L2 and KEAP1 were sequenced in 131 patients with PTC...
February 22, 2018: Head & Neck
https://www.readbyqxmd.com/read/29469940/different-qualifiers-of-aus-flus-thyroid-fna-have-distinct-braf-ras-ret-ptc-and-pax8-pparg-alterations
#11
Claudio Bellevicine, Roberta Sgariglia, Ilaria Migliatico, Elena Vigliar, Melania D'Anna, Maria Antonia Nacchio, Nicola Serra, Umberto Malapelle, Massimo Bongiovanni, Giancarlo Troncone
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) includes fine-needle aspiration (FNA) specimens that cannot straightforwardly be classified as benign or malignant. To determine whether morphological subcategorization based on atypia qualifiers and molecular testing could improve malignancy risk stratification of AUS/FLUS patients, this study assessed the correlation between these qualifiers and the molecular alterations commonly harbored by thyroid neoplasms...
February 22, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29469739/cowden-syndrome-clinical-case-and-a-brief-review
#12
Sofia Lopes, Julia Vide, Elisabete Moreira, Filomena Azevedo
Cowden syndrome is a rare genodermatosis of autosomal dominant inheritance characterized by multiple hamartomas in several organs and an increased risk of malignancies. We present the case of a 53-year-old man with a history of benign and malignant thyroid disease, intestinal polyposis, and Chiari malformation. He had several trichilemmomas, papillomatosis of the oral cavity, macular pigmentation of the glans penis, among other clinical features suggestive of Cowden syndrome. Given the suspicion, genetic study was conducted and PTEN mutation was identified...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469544/-strongyloides-stercoralis-infection-with-hypothyroidism-one-case-report
#13
Sun Yue, Liang Min
This paper reports the diagnosis and treatment of one rare case of thyroid dysfunction caused by Strongyloides stercoralis infection.
April 27, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29469175/presence-of-autoimmune-disease-affects-not-only-risk-but-also-survival-in-patients-with-b-cell-non-hodgkin-lymphoma
#14
Geffen Kleinstern, Mor Averbuch, Rania Abu Seir, Riki Perlman, Dina Ben Yehuda, Ora Paltiel
Although autoimmune diseases (AIDs) are known to predispose to non-Hodgkin lymphoma (NHL), their association with NHL prognosis has rarely been investigated. We examined associations between autoimmunity and B-cell NHL onset by comparing AID history (determined by self-report and medication review and supplemented by chart review where possible) among 435 adult B-NHL patients in Hadassah-Hebrew University Medical Center, diagnosed 2009-2014, and 414 age-and-sex frequency-matched controls. We examined AIDs as a whole, B- and T-cell-mediated AIDs, and autoimmune thyroid diseases...
February 22, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/29469032/pregnancy-in-papillary-thyroid-cancer-survivors
#15
Kemal Beksaç, Fatih Aktoz, Gökçen Örgül, Hasan Tolga Çelik, A Seval Özgü-Erdinç, M Sinan Beksaç
OBJECTIVE: To evaluate "papillary thyroid carcinoma-pregnancy" interaction among cancer survivors. MATERIAL AND METHODS: The clinical records of 8 pregnant women who received treatment for papillary thyroid cancer before their pregnancy were evaluated. Clinical features, pregnancy/ perinatal outcomes and high-risk factors were compared with 45 control cases who were randomly assigned from the institutional perinatal medicine database. RESULTS: Patients in the cancer group were older than the control group (34...
February 20, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29468987/antithyroid-drugs-inactivate-tsh-binding-to-the-tsh-receptor-by-their-reducing-action
#16
Yukio Ochi, Takashi Hachiya, Yukiko Koyama, Nobutoshi Fukuhori, Noriyuki Ashida
The effect of antithyroid drugs(ATDs)[methylmercaptoimidazole (MMI) and propylthiouracil (PTU)] and reducing agents (mercaptoethanol, dithiothreitol and cysteine) on bovine (b) TSH binding to human (h) and porcine (p) TSH receptor (R) was examined. (1) ATDs was pre-incubated with hTSHR coated tube for 1- 4 h, washed free of ATDs, and then 125I-bTSH binding to hTSHR after 1 h incubation was examined. MMI (10-40 mM) decreased 125I-bTSH binding in a dose-dependent manner and binding decreased proportionally as pre-incubation time increased from 1 to 4 h...
February 19, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29468981/lenvatinib-in-the-therapy-of-aggressive-thyroid-cancer-state-of-the-art-and-new-perspectives-with-patents-recently-applied
#17
Silvia Martina Ferrari, Ilaria Ruffilli, Marco Centanni, Camilla Virili, Gabriele Materazzi, Magdalini Alexopoulou, Mario Miccoli, Alessandro Antonelli, Poupak Fallahi
BACKGROUND AND OBJECTIVE: Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor (TKI) of vascular endothelial growth factor receptors (VEGFR1-VEGFR3), fibroblast growth factor receptors (FGFR1-FGFR4), platelet-derived growth factor receptor (PDGFR)α, rearranged during transfection (RET), and v-kit (KIT) signaling networks implicated in tumor angiogenesis. METHOD: Here we review the scientific literature about lenvatinib in the treatment of thyroid cancer...
February 19, 2018: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29468912/hormone-treatments-in-congestive-heart-failure
#18
Lei Lei, Yuanjie Mao
The common ultimate pathological feature for all cardiovascular diseases, congestive heart failure (CHF), is now considered as one of the main public health burdens that is associated with grave implications. Neurohormonal systems play a critical role in cardiovascular homeostasis, pathophysiology, and cardiovascular diseases. Hormone treatments such as the newly invented dual-acting drug valsartan/sacubitril are promising candidates for CHF, in addition to the conventional medications encompassing beta receptor blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and mineralocorticoid receptor antagonists...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29468557/shear-wave-elastography-in-the-diagnostics-of-parathyroid-adenomas-new-application-of-the-method
#19
Adam Stangierski, Kosma Wolinski, Marek Ruchala
PURPOSE: Shear wave elastography (SWE) was described as valuable tool in the diagnostics of distinct types of thyroid lesions, thyroiditis and several other non-thyroidal conditions, such as liver inflammation and fibrosis or diagnostics of breast lesions. The aim of the current study was to assess the appearance of parathyroid adenomas in SWE and to check prospectively if SWE can be valuable additional tool in the diagnostics of pathologically enlarged parathyroids. METHODS: Patients with parathyroid adenomas confirmed by histopathology were included...
February 21, 2018: Endocrine
https://www.readbyqxmd.com/read/29468536/correction-to-letter-image%C3%A2-guided-thermal-ablation-of-benign-thyroid-nodules
#20
Claudio M Pacella
The original version of this article unfortunately was incorrect. The correct title should read: "Comment to article: "Image-guided thermal ablation of benign thyroid nodules" by A. Mainini, et al. J Ultrasound (2017) https://doi.org/10.1007/s40477-016-0221-6 ".
February 21, 2018: Journal of Ultrasound
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