keyword
https://read.qxmd.com/read/37461683/establishing-thresholds-for-cytokine-storm-and-defining-their-relationship-to-disease-severity-in-respiratory-viral-infections
#21
Aisha Souquette, Jeremy Chase Crawford, Joshua Wolf, Ashley Blair, Mona Agrawal, Laura Boywid, Kristin McNair, Nicholas D Hysmith, Chloe Hundman, Azadeh Bahadoran, Sandra R Arnold, Heather S Smallwood, Amanda Green, Paul G Thomas
Previous studies have identified cytokines associated with respiratory virus infection illness outcome. However, few studies have included comprehensive cytokine panels, longitudinal analyses, and/or simultaneous assessment across the severity spectrum. This, coupled with subjective definitions of cytokine storm syndrome (CSS), have contributed to inconsistent findings of cytokine signatures, particularly with COVID severity. Here, we measured 38 plasma cytokines and compared profiles in healthy, SARS-CoV-2 infected, and multisystem inflammatory syndrome in children (MIS-C) patients (n = 169)...
July 7, 2023: bioRxiv
https://read.qxmd.com/read/37458802/the-elusive-luminal-b-breast-cancer-and-the-mysterious-chemokines
#22
JOURNAL ARTICLE
Rogério Agenor de Araújo, Felipe Andrés Cordero da Luz, Eduarda da Costa Marinho, Camila Piqui Nascimento, Thais Rezende Mendes, Etelvina Rocha Tolentino Mosca, Lara de Andrade Marques, Patrícia Ferreira Ribeiro Delfino, Rafael Mathias Antonioli, Ana Cristina Araújo Lemos da Silva, Maria Luiza Gonçalves Dos Reis Monteiro, Morun Bernardino Neto, Marcelo José Barbosa Silva
PURPOSE: Invasive ductal breast cancer (IDC) is heterogeneous. Staging and immunohistochemistry (IH) allow for effective therapy but are not yet ideal. Women with Luminal B tumors show an erratic response to treatment. This prospective study with 81 women with breast cancer aims to improve the prognostic stratification of Luminal B patients. METHODS: This is a prospective translational study with 81 women with infiltrating ductal carcinoma, grouped by TNM staging and immunohistochemistry, for survival analysis, and their correlations with the chemokines...
July 17, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37385841/combination-of-st2-with-organ-specific-biomarker-is-more-sensitive-and-specific-for-the-diagnosis-of-acute-graft-vs-host-disease
#23
JOURNAL ARTICLE
Bingjie Wang, Yue Yin, Yuan Li, Zeyin Liang, Wei Liu, Yuhua Sun, Yujun Dong, Hanyun Ren
BACKGROUND: Diagnosis of acute graft-vs-host disease (aGVHD) based on clinical symptoms and biopsy of involved organ was not satisfactory; reliable plasma biomarkers or their panels would be of great value to increase the sensitivity and specificity for such a fatal complication. METHOD: One hundred two patients who received allogeneic hematopoietic stem cell transplantation in our center were included in this study. Systemic biomarkers of ST2, IP10, IL-2Rα, TNFR1, and organ-specific biomarkers of Elafin, REG-3α, and KRT-18F in plasma were tested by ELISA...
September 2023: Transplantation Proceedings
https://read.qxmd.com/read/37368929/predictive-value-of-serum-biomarkers-for-response-of-limited-stage-aids-associated-kaposi-sarcoma-to-antiretroviral-therapy-with-or-without-concomitant-chemotherapy-in-resource-limited-settings
#24
JOURNAL ARTICLE
Marta Epedlegui, Di Chang, Jeannette Lee, Larry I Magpantay, Margaret Borok, Aggrey Bukuru, Naftali Busakhala, Catherine Godfrey, Mina C Hosseinipour, Minhee Kang, Cecilia Kanyama, Deborah Langat, Rosie Mngqibisa, Noluthando Mwelase, Mulinda Nyirenda, Wadzanai Samaneka, Brenda Hoagland, Thomas B Campbell, Otoniel Martínez-Maza, Susan E Krown
Guidelines for limited-stage human immunodeficiency virus-associated Kaposi sarcoma (AIDS/KS) recommend antiretroviral treatment (ART) as initial therapy. However, many such individuals show worsening KS and require additional chemotherapy. Methods to identify such patients are lacking. Setting: We studied whether serum levels of biomarkers associated with angiogenesis, systemic inflammation, and immune activation, which are elevated in HIV-infected individuals and implicated in the development of KS, could prospectively identify individuals with limited-stage AIDS-KS who would benefit from chemotherapy administered with ART...
June 27, 2023: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/37338014/external-validation-of-genetically-predicted-protein-biomarkers-for-pancreatic-cancer-risk-using-aptamer-based-plasma-levels-a-prospective-analysis-in-the-atherosclerosis-risk-in-communities-study
#25
JOURNAL ARTICLE
Tanxin Liu, Corinne E Joshu, Jiayun Lu, Anna Prizment, Nilanjan Chatterjee, Josef Coresh, Lang Wu, Elizabeth A Platz
Genetically predicted proteins have been associated with pancreatic cancer risk previously. We aimed to externally validate the associations of 53 candidate proteins with pancreatic cancer risk using directly measured, prediagnostic levels. We conducted a prospective cohort study of 10 355 US Black and White men and women in the Atherosclerosis Risk in Communities (ARIC) study. Aptamer-based plasma proteomic profiling was previously performed using blood collected in 1993 to 1995, from which the proteins were selected...
June 20, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37188519/expression-profile-of-cytokines-and-chemokines-in-a-mouse-high-altitude-cerebral-edema-model
#26
JOURNAL ARTICLE
Zibi Shi, Xiufang Jiang, Yanan Geng, Xiangpei Yue, Jiayue Gao, Xiang Cheng, Ming Zhao, Lingling Zhu
INTRODUCTION: High-altitude cerebral edema (HACE) is considered to be the end-stage of acute mountain sickness (AMS); however, its pathophysiological mechanism remains unknown. Increasing evidences support that inflammation is an important risk factor for the occurrence of HACE. Including our published papers, previous studies demonstrated that the levels of IL-6, IL-1β, and TNF-α in both serum and hippocampus were increased in the mouse HACE model induced by LPS stimulation combined with hypobaric hypoxia exposure; however, the expression profile of other cytokines and chemokines remains unknown...
2023: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/37159131/serum-biomarkers-for-monitoring-response-to-tuberculosis-treatment-an-assessment-of-the-effect-of-different-covariates-among-slow-and-fast-treatment-responders
#27
JOURNAL ARTICLE
Anna Ritah Namuganga, Bernard Ssentalo Bagaya, Novel N Chegou, Harriet Mayanja-Kizza
Introduction: The long duration of tuberculosis treatment, as well as the 2-year post-treatment follow-up period often required for predicting relapse, present a hindrance to drug development and treatment monitoring efforts. There is an urgent need for biomarkers of treatment response to aid treatment time shortening, clinical decision-making, and inform clinical trials. Objectives: To assess the abilities of selected serum host biomarkers to predict treatment response among active PTB patients. Methods: Active pulmonary TB patients (n = 53) as confirmed by sputum MGIT culture were enrolled at a TB treatment center in Kampala, Uganda...
May 9, 2023: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/37108262/covid-19-biomarkers-at-the-crossroad-between-patient-stratification-and-targeted-therapy-the-role-of-validated-and-proposed-parameters
#28
REVIEW
Manuela Rizzi, Davide D'Onghia, Stelvio Tonello, Rosalba Minisini, Donato Colangelo, Mattia Bellan, Luigi Mario Castello, Francesco Gavelli, Gian Carlo Avanzi, Mario Pirisi, Pier Paolo Sainaghi
Clinical knowledge about SARS-CoV-2 infection mechanisms and COVID-19 pathophysiology have enormously increased during the pandemic. Nevertheless, because of the great heterogeneity of disease manifestations, a precise patient stratification at admission is still difficult, thus rendering a rational allocation of limited medical resources as well as a tailored therapeutic approach challenging. To date, many hematologic biomarkers have been validated to support the early triage of SARS-CoV-2-positive patients and to monitor their disease progression...
April 12, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37099456/pathogenic-gene-spectrum-and-clinical-implication-in-chinese-patients-with-lupus-nephritis
#29
JOURNAL ARTICLE
Changming Zhang, Xu Han, Ying Jin, Xiang Chen, Cheng Gong, Jiahui Peng, Yusha Wang, Xiaoxin Luo, Zhaohui Yang, Yangyang Zhang, Weiguo Wan, Xiaohui Liu, Jianhua Mao, Haiguo Yu, Jingyi Li, Li Liu, Li Sun, Sirui Yang, Yu An, Zhengzhao Liu, Erzhi Gao, Honghao Zhu, Yinghua Chen, Xiaomin Yu, Qing Zhou, Zhihong Liu
BACKGROUND: Lupus nephritis is a rare immunological disorder. Genetic factors are considered important in its causation. We aim to systematically investigate the rare pathogenic gene variants in patients with lupus nephritis. METHODS: Whole-exome sequencing was used to screen pathogenic gene variants in 1886 probands with lupus nephritis. Variants were interpreted based on known pathogenic variants or the American College of Medical Genetics and Genomics (ACMG) guideline, and studied by functional analysis including RNA sequencing, quantitative PCR, Cytometric Bead Array, western blotting, etc...
April 26, 2023: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/36949034/multicenter-validation-of-a-urine-cxcl10-assay-for-noninvasive-monitoring-of-renal-transplants
#30
MULTICENTER STUDY
Julie Ho, Stefan Schaub, Annette M Jackson, Robert Balshaw, Robert Carroll, Sylvia Cun, Sacha A De Serres, Daniel Fantus, Joelle Handschin, Gideon Hönger, Anthony M Jevnikar, Marc Kleiser, Jar-How Lee, Yan Li, Peter Nickerson, Rui Pei, Denise Pochinco, Remi Shih, Michael Trinh, Jason Wang, Julie Nguyen, Stuart Knechtle
BACKGROUND: Urine CXCL10 (C-X-C motif chemokine ligand 10, interferon gamma-induced protein 10 [IP10]) outperforms standard-of-care monitoring for detecting subclinical and early clinical T-cell-mediated rejection (TCMR) and may advance TCMR therapy development through biomarker-enriched trials. The goal was to perform an international multicenter validation of a CXCL10 bead-based immunoassay (Luminex) for transplant surveillance and compare with an electrochemiluminescence-based (Meso Scale Discovery [MSD]) assay used in transplant trials...
July 1, 2023: Transplantation
https://read.qxmd.com/read/36891154/associations-of-circulation-levels-of-cytokines-with-birthweight-preterm-birth-spontaneous-miscarriages-and-stillbirth-a-mendelian-randomization-analysis
#31
JOURNAL ARTICLE
Honghong Wang, Jinghang Jiang, Tingwei Jin, Yifu Wang, Mingli Li, Shengzhu Huang, Juanjuan Xie, Zhongyuan Chen, Yi Guo, Jie Zheng, Yonghua Jiang, Zengnan Mo
Background: The association between immune imbalances and adverse pregnancy outcomes has been extensive investigated by observational studies, but remain unclear. Thus, this study aimed to establish the causality of the circulation levels of cytokines on adverse pregnancy outcomes, such as offspring's birthweight (BW), preterm birth (PTB), spontaneous miscarriage (SM), and stillbirth (SB). Methods: Two-sample Mendelian randomization (MR) analysis was employed to investigate potential causal relations between 41 cytokines and pregnancy outcomes on the basis of previously published GWAS datasets...
2023: Frontiers in Genetics
https://read.qxmd.com/read/36869232/immune-related-toxicity-and-soluble-profile-in-patients-affected-by-solid-tumors-a-network-approach
#32
JOURNAL ARTICLE
Andrea Botticelli, Alessio Cirillo, Giulia Pomati, Enrico Cortesi, Ernesto Rossi, Giovanni Schinzari, Giampaolo Tortora, Silverio Tomao, Giulia Fiscon, Lorenzo Farina, Simone Scagnoli, Simona Pisegna, Fabio Ciurluini, Antonella Chiavassa, Sasan Amirhassankhani, Fulvia Ceccarelli, Fabrizio Conti, Alessandra Di Filippo, Ilaria Grazia Zizzari, Chiara Napoletano, Aurelia Rughetti, Marianna Nuti, Silvia Mezi, Paolo Marchetti
BACKGROUND: Immune checkpoint inhibitors (ICIs) have particular, immune-related adverse events (irAEs), as a consequence of interfering with self-tolerance mechanisms. The incidence of irAEs varies depending on ICI class, administered dose and treatment schedule. The aim of this study was to define a baseline (T0) immune profile (IP) predictive of irAE development. METHODS: A prospective, multicenter study evaluating the immune profile (IP) of 79 patients with advanced cancer and treated with anti-programmed cell death protein 1 (anti-PD-1) drugs as a first- or second-line setting was performed...
March 3, 2023: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/36851164/the-combination-of-an-mrna-immunogen-a-tlr7-agonist-and-a-pd1-blocking-agent-enhances-in-vitro-hiv-t-cell-immune-responses
#33
JOURNAL ARTICLE
Lorena Usero, Lorna Leal, Carmen Elena Gómez, Laia Miralles, Elena Aurrecoechea, Ignasi Esteban, Berta Torres, Alexy Inciarte, Beatriz Perdiguero, Mariano Esteban, Felipe García, Montserrat Plana
The development of new strategies to achieve a functional cure for HIV remains a priority. We tested a novel HIV therapeutic vaccine using unmodified mRNA (TMEP-B) and mRNA modified by 1-methyl-3'-pseudouridylyl (TMEP-Bmod) expressing both a multiepitopic sequences from Gag, Pol, and Nef proteins, including different CD4 and CD8 T-cell epitopes functionally associated with HIV control in transfected monocyte-derived dendritic cells (MDDCs) obtained from HIV infected patients. In vitro assays were used to test the mRNAs alone and in combination with immunomodulator agents, such as the TLR-7 agonist Vesatolimod and the PD-1 antagonist Nivolumab to try to improve HIV-specific cellular immune responses...
January 28, 2023: Vaccines
https://read.qxmd.com/read/36788233/quila%C3%A2-adjuvanted-coxevac%C3%A2-sustains-th1-cd8-type-immunity-and-increases-protection-in-coxiella-burnetii-challenged-goats
#34
JOURNAL ARTICLE
Sara Tomaiuolo, Wiebke Jansen, Susana Soares Martins, Bert Devriendt, Eric Cox, Marcella Mori
Coxevac® is the EMA-approved veterinary vaccine for the protection of cattle and goats against Q fever, a zoonotic bacterial disease due to Coxiella burnetii. Since Coxevac® reduces bacterial shedding and clinical symptoms but does not prevent infection, novel, ready-to-use vaccine formulations are needed to increase its immunogenicity. Here, a goat vaccination-challenge model was used to evaluate the impact of the commercially available saponin-based QuilA® adjuvant on Coxevac® immunity...
February 14, 2023: NPJ Vaccines
https://read.qxmd.com/read/36746339/rsv-induced-expanded-ciliated-cells-contribute-to-bronchial-wall-thickening
#35
JOURNAL ARTICLE
Sattya N Talukdar, Jaspreet Osan, Ken Ryan, Bryon Grove, Danielle Perley, Bony D Kumar, Shirley Yang, Sydney Dallman, Lauren Hollingsworth, Kristina L Bailey, Masfique Mehedi
Viral infection, particularly respiratory syncytial virus (RSV), causes inflammation in the bronchiolar airways (bronchial wall thickening, also known as bronchiolitis). This bronchial wall thickening is a common pathophysiological feature in RSV infection, but it causes more fatalities in infants than in children and adults. However, the molecular mechanism of RSV-induced bronchial wall thickening remains unknown, particularly in healthy adults. Using highly differentiated pseudostratified airway epithelium generated from primary human bronchial epithelial cells, we revealed RSV-infects primarily ciliated cells...
February 4, 2023: Virus Research
https://read.qxmd.com/read/36676067/upregulation-of-neuroinflammatory-protein-biomarkers-in-acute-rhegmatogenous-retinal-detachments
#36
JOURNAL ARTICLE
Minali Prasad, Jia Xu, Joshua S Agranat, Weiming Xia, Sarah Daley, Steven Ness, Xuejing Chen, Nicole H Siegel, Thor D Stein, Jaeyoon Chung, Manju L Subramanian
The purpose of this study is to characterize the inflammatory cytokine profile in rhegmatogenous retinal detachments (RRDs) compared to surgical controls. Vitreous humor was collected from patients undergoing vitrectomy for RRD and noninflammatory vitreoretinal diseases. A quantitative immunoassay was used to measure the levels of 36 cytokine markers. Linear regression analysis with the duration of detachment as the predictor and log-transformed cytokine levels as the outcome was conducted for normally distributed cytokines as determined by the Shapiro-Wilk test...
December 31, 2022: Life
https://read.qxmd.com/read/36670590/one-hundred-consecutive-neutropenic-febrile-episodes-demonstrate-that-cxcr3-ligands-have-predictive-value-in-discriminating-the-severity-of-infection-in-children-with-cancer
#37
JOURNAL ARTICLE
Małgorzata Nowak, Katarzyna Bobeff, Justyna Walenciak, Julia Kołodrubiec, Krystyna Wyka, Wojciech Młynarski, Joanna Trelińska
This study assesses the value of the CXCR3 ligands CXCL9/MIG, CXCL10/IP-10 and CXCL11/I-TAC when used to supplement the standard infection markers C-reactive protein (CRP) and procalcitonin (PCT) in the diagnostic algorithm of neutropenic fever in children with cancer. The concentration of CRP, PCT and chemokines was determined during the first hour of fever and 12-24 h afterwards in pediatric oncology patients with neutropenia. Among 100 consecutive febrile episodes in neutropenic patients, 34 cases demonstrated fever of unknown origin (FUO) (group A), 47 demonstrated mild clinically or microbiologically proven infection (Group B) and 19 severe infection (Group C)...
December 25, 2022: Children
https://read.qxmd.com/read/36599629/jak-inhibitors-disrupt-t-cell-induced-proinflammatory-macrophage-activation
#38
JOURNAL ARTICLE
Mukanthu H Nyirenda, Jagtar Singh Nijjar, Marina Frleta-Gilchrist, Derek S Gilchrist, Duncan Porter, Stefan Siebert, Carl S Goodyear, Iain B McInnes
OBJECTIVES: Macrophage subsets, activated by T cells, are increasingly recognised to play a central role in rheumatoid arthritis (RA) pathogenesis. Janus kinase (JAK) inhibitors have proven beneficial clinical effects in RA. In this study, we investigated the effect of JAK inhibitors on the generation of cytokine-activated T (Tck) cells and the production of cytokines and chemokines induced by Tck cell/macrophage interactions. METHODS: CD14+ monocytes and CD4+ T cells were purified from peripheral blood mononuclear cells from buffy coats of healthy donors...
January 2023: RMD Open
https://read.qxmd.com/read/36551295/chronic-bedridden-condition-is-reflected-by-substantial-changes-in-plasma-inflammatory-profile
#39
JOURNAL ARTICLE
Roberta Magliozzi, Anna Pedrinolla, Stefania Rossi, Anna Maria Stabile, Elisa Danese, Giuseppe Lippi, Federico Schena, Massimiliano Calabrese, Massimo Venturelli Venturelli
Absent or reduced physical activity and spontaneous movement over days, weeks, or even years may lead to problems in almost every major organ/system in the human body. In this study, we investigated whether the dysregulation and alteration of plasma protein inflammatory profiling can stratify chronic bedridden conditions observed in 22 elderly chronic bedridden (CBR) individuals with respect to 11 age-matched active (OLD) controls. By using a combination of immune-assay multiplex techniques, a complex of 27 inflammatory mediators was assessed in the plasma collected from the two groups...
December 13, 2022: Biomolecules
https://read.qxmd.com/read/36497475/cytokines-and-lymphoid-populations-as-potential-biomarkers-in-locally-and-borderline-pancreatic-adenocarcinoma
#40
JOURNAL ARTICLE
Iranzu González-Borja, Antonio Viúdez, Emilia Alors-Pérez, Saioa Goñi, Irene Amat, Ismael Ghanem, Roberto Pazo-Cid, Jaime Feliu, Laura Alonso, Carlos López, Virginia Arrazubi, Javier Gallego, Jairo Pérez-Sanz, Irene Hernández-García, Ruth Vera, Justo P Castaño, Joaquín Fernández-Irigoyen
Despite its relative low incidence, PDAC is one of the most aggressive and lethal types of cancer, being currently the seventh leading cause of cancer death worldwide, with a 5-year survival rate of 10.8%. Taking into consideration the necessity to improve the prognosis of these patients, this research has been focused on the discovery of new biomarkers. For this purpose, patients with BL and resectable disease were recruited. Serum cytokines and growth factors were monitored at different time points using protein arrays...
December 5, 2022: Cancers
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