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https://www.readbyqxmd.com/read/28419006/plasma-interferon-gamma-inducible-protein-10-ip10-level-associates-with-abnormal-memory-b-cells-phenotypes-in-perinatal-hiv-infection
#1
German A Contreras, James R Murphy, Gloria P Heresi
We demonstrate for perinatally HIV infected children and adolescents receiving cART and in good clinical status with respect to HIV disease that high concentrations of IP10 associate with increased exhausted memory B cells.
April 17, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28380403/5-triphosphate-sirna-targeting-mdr1-reverses-multi-drug-resistance-and-activates-rig-i-induced-immune-stimulatory-and-apoptotic-effects-against-human-myeloid-leukaemia-cells
#2
Dengzhe Li, Robert Peter Gale, Yanfeng Liu, Baoxia Lei, Yuan Wang, Dongmei Diao, Mei Zhang
Multi-drug resistance (MDR), immune suppression and decreased apoptosis are important causes of therapy-failure in leukaemia. Short interfering RNAs (siRNAs) down-regulate gene transcription, have sequence-independent immune-stimulatory effects and synergize with other anti-cancer therapies in some experimental models. We designed a siRNA targeting MDR1 with 5'-triphosphate ends (3p-siRNA-MDR1). Treatment of leukaemia cells with 3p-siRNA-MDR1 down-regulated MDR1 expression, reduced-drug resistance and induced immune and pro-apoptotic effects in drug-resistant HL-60/Adr and K562/Adr human leukaemia cell lines...
March 21, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28378188/apigenin-suppresses-the-senescence-associated-secretory-phenotype-and-paracrine-effects-on-breast-cancer-cells
#3
Kevin M Perrott, Christopher D Wiley, Pierre-Yves Desprez, Judith Campisi
Apigenin (4',5,7,-trihydroxyflavone) is a flavonoid found in certain herbs, fruits, and vegetables. Apigenin can attenuate inflammation, which is associated with many chronic diseases of aging. Senescent cells-stressed cells that accumulate with age in mammals-display a pro-inflammatory senescence-associated secretory phenotype (SASP) that can drive or exacerbate several age-related pathologies, including cancer. Flavonoids, including apigenin, were recently shown to reduce the SASP of a human fibroblast strain induced to senesce by bleomycin...
April 4, 2017: GeroScience
https://www.readbyqxmd.com/read/28376104/inositol-1-4-5-trisphosphate-dependent-nuclear-calcium-signals-regulate-angiogenesis-and-cell-motility-in-triple-negative-breast-cancer
#4
Erika Guimarães, Rodrigo Machado, Matheus de Castro Fonseca, Andressa França, Clarissa Carvalho, Ana Cândida Araújo E Silva, Brígida Almeida, Puebla Cassini, Bárbara Hissa, Luciana Drumond, Carlos Gonçalves, Gabriel Fernandes, Marina De Brot, Márcio Moraes, Lucíola Barcelos, José Miguel Ortega, André Oliveira, M Fátima Leite
Increases in nuclear calcium concentration generate specific biological outcomes that differ from those resulting from increased cytoplasmic calcium. Nuclear calcium effects on tumor cell proliferation are widely appreciated; nevertheless, its involvement in other steps of tumor progression is not well understood. Therefore, we evaluated whether nuclear calcium is essential in other additional stages of tumor progression, including key steps associated with the formation of the primary tumor or with the metastatic cascade...
2017: PloS One
https://www.readbyqxmd.com/read/28375554/inflammatory-responses-to-influenza-vaccination-at-the-extremes-of-age
#5
Jacqueline U McDonald, Ziyun Zhong, Helen T Groves, John S Tregoning
Age affects the immune response to vaccination, with individuals at the extremes of age responding poorly. The initial inflammatory response to antigenic materials shapes the subsequent adaptive response and so understanding is required about the effect of age on the profile of acute inflammatory mediators. In this study we measured the local and systemic inflammatory response after influenza vaccination or infection in neonatal, young adult and aged mice. Mice were immunised intramuscularly with inactivated influenza vaccine with and without the adjuvant MF59 and then challenged with H1N1 influenza...
April 4, 2017: Immunology
https://www.readbyqxmd.com/read/28373098/a-comprehensive-evaluation-of-nasal-and-bronchial-cytokines-and-chemokines-following-experimental-rhinovirus-infection-in-allergic-asthma-increased-interferons-ifn-%C3%AE-and-ifn-%C3%AE-and-type-2-inflammation-il-5-and-il-13
#6
Trevor T Hansel, Tanushree Tunstall, Maria-Belen Trujillo-Torralbo, Betty Shamji, Ajerico Del-Rosario, Jaideep Dhariwal, Paul D W Kirk, Michael P H Stumpf, Jens Koopmann, Aurica Telcian, Julia Aniscenko, Leila Gogsadze, Eteri Bakhsoliani, Luminita Stanciu, Nathan Bartlett, Michael Edwards, Ross Walton, Patrick Mallia, Toby M Hunt, Trevor L Hunt, Duncan G Hunt, John Westwick, Matthew Edwards, Onn Min Kon, David J Jackson, Sebastian L Johnston
BACKGROUND: Rhinovirus infection is a major cause of asthma exacerbations. OBJECTIVES: We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. METHODS: We used nasosorption on days 0, 2-5 and 7 and bronchosorption at baseline and day 4 to sample mucosal lining fluid to investigate airway mucosal responses to rhinovirus infection in patients with allergic asthma (n=28) and healthy non-atopic controls (n=11), by using a synthetic absorptive matrix and measuring levels of 34 cytokines and chemokines using a sensitive multiplex assay...
March 28, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28363866/interferon-induces-interleukin-8-and-bone-marrow-stromal-cell-antigen-2-expression-inhibiting-the-production-of-hepatitis-b-virus-surface-antigen-from-human-hepatocytes
#7
Yuki Haga, Tatsuo Kanda, Shingo Nakamoto, Masato Nakamura, Reina Sasaki, Shuang Wu, Osamu Yokosuka
Hepatitis B virus (HBV) surface antigen (HBsAg) loss is one of the treatment goals of chronic HBV infection. Bone marrow stromal cell antigen 2 (BST2) is one of the interferon (IFN)-stimulated genes (ISGs) and inhibits the release of various enveloped viruses. Here we examined the effects of antiviral treatment on HBsAg levels and its intracellular mechanism in HBsAg-producing hepatocytes. In PLC/PRF/5 and Huh1, IFNα-2a treatment decreased HBsAg levels in their conditioned media. Upregulation of interleukin 8 (IL8), toll-like receptor 2 (TLR2) and interferon gamma-induced protein 10 (IP10) mRNAs was associated with the reduction of HBsAg in both PLC/PRF/5 and Huh1...
March 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28326169/circulating-ll37-targets-plasma-extracellular-vesicles-to-immune-cells-and-intensifies-beh%C3%A3-et-s-disease-severity
#8
Tamer Kahraman, Gozde Gucluler, Ismail Simsek, Fuat Cem Yagci, Muzaffer Yildirim, Can Ozen, Ayhan Dinc, Mayda Gursel, Lolai Ikromzoda, Tolga Sutlu, Stephen Gay, Ihsan Gursel
Behçet's disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin derived antimicrobial peptide LL37 associates with and directs plasma extracellular vesicles (EV) to immune cells, thereby leading to enhanced immune activation aggravating BD pathology. Notably, disease activity was correlated with elevated levels of circulating LL37 and EV plasma concentration...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28316372/dyslipidemia-rather-than-type-2-diabetes-mellitus-or-chronic-periodontitis-affects-the-systemic-expression-of-pro-and-anti-inflammatory-genes
#9
Rafael Nepomuceno, Bárbara Scoralick Villela, Sâmia Cruz Tfaile Corbi, Alliny De Souza Bastos, Raquel Alves Dos Santos, Catarina Satie Takahashi, Silvana Regina Perez Orrico, Raquel Mantuaneli Scarel-Caminaga
A high percentage of type 2 diabetes mellitus (T2D) patients are also affected by dyslipidemia and chronic periodontitis (CP), but no studies have determined the gene expression in patients that are simultaneously affected by all three diseases. We investigated the systemic expression of immune-related genes in T2D, dyslipidemia, and CP patients. One hundred and fifty patients were separated into five groups containing 30 individuals each: (G1) poorly controlled T2D with dyslipidemia and CP; (G2) well-controlled T2D with dyslipidemia and CP; (G3) normoglycemic individuals with dyslipidemia and CP; (G4) healthy individuals with CP; (G5) systemic and periodontally healthy individuals...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28278706/high-expression-levels-of-ip10-cxcl10-are-associated-with-modulation-of-the-natural-killer-cell-compartment-in-multiple-myeloma
#10
Giovanni Bernardini, Elisabetta Vulpis, Valentina Bonanni, Helena Stabile, Maria Rosaria Ricciardi, Maria Teresa Petrucci, Angela Gismondi, Angela Santoni, Alessandra Zingoni
No abstract text is available yet for this article.
February 28, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28246678/the-association-of-urinary-interferon-gamma-inducible-protein-10-ip10-cxcl10-levels-with-kidney-allograft-rejection
#11
Ali Raza, Sadaf Firasat, Shagufta Khaliq, Tahir Aziz, Muhammed Mubarak, Syed Ali Anwar Naqvi, Syed Qasim Mehdi, Syed Adib-Ul-Hasan Rizvi, Aiysha Abid
BACKGROUND: Interferon-gamma inducible protein-10 (IP-10/CXCL10) is a chemokine involved in the alloimmune response against kidney allograft. We aimed to investigate the association of urinary CXCL10 protein levels with rejection in renal transplant patients. METHODS: A total of 273 urine samples from (biopsy-proven) rejection and non-rejection patients and controls were included in this study. CXCL10 levels were analyzed for association with rejection. RESULTS: The data showed statistically significant differences in the CXCL10 levels between rejection vs...
February 28, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28170444/impaired-toll-like-receptor-7-and-9-induced-immune-activation-in-chronic-spinal-cord-injured-patients-contributes-to-immune-dysfunction
#12
Gozde Gucluler, Emre Adiguzel, Bilgi Gungor, Tamer Kahraman, Mayda Gursel, Bilge Yilmaz, Ihsan Gursel
Reduced immune activation or immunosuppression is seen in patients withneurological diseases. Urinary and respiratory infections mainly manifested as septicemia and pneumonia are the most frequent complications following spinal cord injuries and they account for the majority of deaths. The underlying reason of these losses is believed to arise due to impaired immune responses to pathogens. Here, we hypothesized that susceptibility to infections of chronic spinal cord injured (SCI) patients might be due to impairment in recognition of pathogen associated molecular patterns and subsequently declining innate and adaptive immune responses that lead to immune dysfunction...
2017: PloS One
https://www.readbyqxmd.com/read/28106169/inhibition-of-nucks-facilitates-corneal-recovery-following-alkali-burn
#13
Ming-Wai Poon, Dan Jiang, Peng Qin, Yuelin Zhang, Beiying Qiu, Sumit Chanda, Vinay Tergaonkar, Qing Li, Ian Y Wong, Zhendong Yu, Hung-Fat Tse, David S H Wong, Qizhou Lian
Corneal wound healing involves a complex cascade of cytokine-controlled cellular events, including inflammatory and angiogenesis responses that are regulated by transcriptional chromatin remodeling. Nuclear Ubiquitous Casein and cyclin-dependent Kinase Substrate (NUCKS) is a key chromatin modifier and transcriptional regulator of metabolic signaling. In this study, we investigated the role of NUCKS in corneal wound healing by comparing its effects on corneal alkali burn in NUCKS knockout (NKO) and NUCKS wild-type (NWT) mice...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28060925/associations-of-self-reported-sleep-quality-with-circulating-interferon-gamma-inducible-protein-10-interleukin-6-and-high-sensitivity-c-reactive-protein-in-healthy-menopausal-women
#14
Wan-Yu Huang, Chih-Cheng Huang, Chia-Chu Chang, Chew-Teng Kor, Ting-Yu Chen, Hung-Ming Wu
INTRODUCTION: Sleep disturbance is very common in menopausal women and poor sleep quality has been linked to systemic inflammation. However, the impact of poor sleep quality on health outcomes of menopausal women remains unclear. This study evaluated the relationships between sleep quality and inflammation in menopausal women. PARTICIPANTS AND DESIGN: This cross-sectional study enrolled 281 healthy women aged 45 to 60 years. The Pittsburgh Sleep Quality Index (PSQI) was used to measure quality of sleep...
2017: PloS One
https://www.readbyqxmd.com/read/28051885/elevated-serum-interferon-%C3%AE-inducible-protein-10-in-women-with-polycystic-ovary-syndrome
#15
Hongli Deng, Zhibo Li, Guang Liu, Xianhua Li, Yong Chen, Yong Zhang, Yifan Sun, Jinjian Fu
BACKGROUND: Interferon γ-induced protein 10 kDa (IP10/CXCL10) is a chemokine related to endocrine disorders; however, the serum concentrations of IP10 in women with polycystic ovary syndrome (PCOS) have not yet been reported. Therefore, we investigated whether IP10 is increased in PCOS patients and its potential clinical value in PCOS patients. METHODS: For this research, the serum IP10, glucose, insulin, high sensitivity C-reactive protein (hs-CRP), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and total testosterone (TT) concentrations were measured in 60 women with PCOS and healthy controls...
January 4, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28011441/cannabinoid-receptors-on-peripheral-leukocytes-from-patients-with-schizophrenia-evidence-for-defective-immunomodulatory-mechanisms
#16
Salvina Maria de Campos-Carli, Marcio Sobreira Araújo, Amanda Cardoso de Oliveira Silveira, Vitor Bortolo de Rezende, Natalia Pessoa Rocha, Rodrigo Ferretjans, Rafael Ribeiro-Santos, Andrea Teixeira-Carvalho, Olindo Assis Martins-Filho, Michael Berk, João Vinícius Salgado, Antonio Lucio Teixeira
OBJECTIVES: to evaluate cannabinoid receptors (CBRs) expression on peripheral immune cells, i.e., blood monocytes, neutrophils, lymphocytes, and NK cells, and their relationship to a wide range of serum cytokine levels in subjects with schizophrenia and controls. METHODS: A sample of 55 people with chronic schizophrenia and 48 controls were enrolled in the study. The expression of the cannabinoid receptors CB1R and CB2R was evaluated in peripheral blood leukocytes by flow cytometry...
December 3, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27853634/dynamic-alterations-of-bone-marrow-cytokine-landscape-of-myelodysplastic-syndromes-patients-treated-with-5-azacytidine
#17
Alena Moudra, Sona Hubackova, Veronika Machalova, Marketa Vancurova, Jiri Bartek, Milan Reinis, Zdenek Hodny, Anna Jonasova
Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal stem cell disorders characterized by ineffective hematopoiesis frequently progressing into acute myeloid leukemia (AML), with emerging evidence implicating aberrant bone marrow (BM) microenvironment and inflammation-related changes. 5-azacytidine (5-AC) represents standard MDS treatment. Besides inhibiting DNA/RNA methylation, 5-AC has been shown to induce DNA damage and apoptosis in vitro. To provide insights into in vivo effects, we assessed the proinflammatory cytokines alterations during MDS progression, cytokine changes after 5-AC, and contribution of inflammatory comorbidities to the cytokine changes in MDS patients...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27810706/how-to-measuring-blood-cytokines-in-biological-psychiatry-using-commercially-available-multiplex-immunoassays
#18
Raoul Belzeaux, Marie-Noëlle Lefebvre, Anne Lazzari, Tifenn Le Carpentier, Julia-Lou Consoloni, Xavier Zendjidjian, Mocrane Abbar, Philippe Courtet, Jean Naudin, José Boucraut, Pierre Gressens, Nicolas Glaichenhaus, El Chérif Ibrahim
Cytokines produced by both immune and non-immune cells are likely to play roles in the development and/or progression of psychiatric disorders. Indeed, many investigators have compared the blood cytokine levels in psychiatric patients with those of healthy controls or monitored their levels in patients during disease progression to identify biomarkers. Nevertheless, very few studies have confirmed that such cytokines remain stable in healthy individuals through periods of weeks and months. This is an important issue to consider before using blood cytokine levels as biomarkers of disease traits, disease state, or treatment response...
January 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27764787/pdgfr-alpha-inhibits-melanoma-growth-via-cxcl10-ip-10-a-multi-omics-approach
#19
Daniela D'Arcangelo, Francesco Facchiano, Giovanni Nassa, Andrea Stancato, Annalisa Antonini, Stefania Rossi, Cinzia Senatore, Martina Cordella, Claudio Tabolacci, Annamaria Salvati, Roberta Tarallo, Alessandro Weisz, Angelo M Facchiano, Antonio Facchiano
Melanoma is the most aggressive skin-cancer, showing high mortality at advanced stages. Platelet Derived Growth Factor Receptor-alpha (PDGFR-alpha) potently inhibits melanoma- and endothelium-proliferation and its expression is significantly reduced in melanoma-biopsies, suggesting that melanoma progression eliminates cells expressing PDGFR-alpha. In the present study transient overexpression of PDGFR-alpha in endothelial (HUVEC) and melanoma (SKMel-28, A375, Preyer) human-cells shows strong anti-proliferative effects, with profound transcriptome and miRNome deregulation...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27696532/uptake-of-parasite-derived-vesicles-by-astrocytes-and-microglial-phagocytosis-of-infected-erythrocytes-may-drive-neuroinflammation-in-cerebral-malaria
#20
Sandeep K Shrivastava, Esther Dalko, Delphine Delcroix-Genete, Fabien Herbert, Pierre-André Cazenave, Sylviane Pied
Astrocytes and microglia are activated during cerebral malaria (CM) and contribute to the production and release of several mediators during neuroinflammatory processes. Whether these changes are the consequence of a direct crosstalk between glial cells and the malarial parasite and how these cells participate in the pathogenesis of CM is not yet clear. We therefore examined the interaction of astrocytes and microglia with Plasmodium berghei ANKA-infected red blood cells using primary cell cultures derived from newborn C57BL/6 mice...
October 3, 2016: Glia
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