Tracy N Phiri, Kuda Mutasa, Sandra Rukobo, Margaret Govha, Patience Mushayanembwa, Simutanyi Mwakamui, Tafhima Haider, Kanekwa Zyambo, Cherlynn Dumbura, Joice Tome, Thompson Runodamoto, Leah Chidamba, Florence D Majo, Deophine Ngosa, Kanta Chandwe, Chanda Kapoma, Benjamin Mwapenya, Wadzanai Mufukari, Jonathan P Sturgeon, Ruairi C Robertson, Melanie Smuk, Robert Ntozini, Kusum Nathoo, Beatrice Amadi, Paul Kelly, Mutsa Bwakura-Dangarembizi, Andrew J Prendergast, Claire D Bourke
Children with severe acute malnutrition (SAM) have high infectious mortality and morbidity, implicating defects in their immune defenses. We hypothesized that circulating innate immune cells from children (0 to 59 months) hospitalized with SAM in Zambia and Zimbabwe ( n = 141) have distinct capacity to respond to bacteria relative to adequately nourished healthy controls ( n = 92). SAM inpatients had higher neutrophil and monocyte Escherichia coli binding capacity but lower monocyte activation and proinflammatory mediator secretion in response to lipopolysaccharide or heat-killed Salmonella typhimurium than controls...
November 3, 2023: Science Advances