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Shohei Murakami, Hozumi Motohashi
The KEAP1-NRF2 system is an inducible molecular mechanism enhancing transcriptions of several cytoprotective genes in response to xenobiotics and oxidative stress. Recently, the KEAP1-NRF2 system has been suggested to directly regulate a portion of the genes related to cell proliferation and differentiation. In hematopoietic cells, NRF2 activation plays a role in maintenance and cell fate determination of hematopoietic stem cells, as well as in maturation processes and homeostasis of megakaryocytes and erythrocytes...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Matthew A J Duncton, Rajinder Singh
A one-pot and scalable synthesis of tetrazolones (tetrazol-5-ones) from acid chlorides using azidotrimethylsilane is presented. The reaction tolerates many functional groups and can furnish aryl-, heteroaryl-, alkenyl-, or alkyl-substituted tetrazolone products in moderate to excellent yield (14-94%). No reduction in yield was observed when the reaction was undertaken on a larger-scale (20-36 g). The method could be used for the late-stage functionalization of pharmaceuticals, to provide tetrazolone congeners of the marketed drugs aspirin, indomethacin, probenecid, telmisartan, bexarotene, niacin (vitamin B3), and the active metabolite of the recently-launched immuno-modulatory agent, BG-12 (Tecfidera(®))...
October 4, 2016: Organic & Biomolecular Chemistry
Sung Han Kim, Sohee Kim, Jungnam Joo, Ho Kyung Seo, Jae Young Joung, Kang Hyun Lee, Jinsoo Chung
BACKGROUND: To identify predictors of prolonged or shortened progression-free survival (PFS) and overall survival (OS) among patients with metastatic renal cell carcinoma (mRCC) who received first-line targeted therapies. METHODS: This retrospective study included 146 patients with mRCC who were treated during 2007-2015. These patients were divided into a group with the worst response (WG), an expected group (EG), and a group with the best response (BG), based on their PFS (≤3 monthsnths, 3-18 monthsnths, and >18 monthsnths, respectively) and OS (<1 year, 1-3 years, and >3 years, respectively)...
2016: BMC Cancer
Ulf Schulze-Topphoff, Michel Varrin-Doyer, Kara Pekarek, Collin M Spencer, Aparna Shetty, Sharon A Sagan, Bruce A C Cree, Raymond A Sobel, Brian T Wipke, Lawrence Steinman, Robert H Scannevin, Scott S Zamvil
Dimethyl fumarate (DMF) (BG-12, Tecfidera) is a fumaric acid ester (FAE) that was advanced as a multiple sclerosis (MS) therapy largely for potential neuroprotection as it was recognized that FAEs are capable of activating the antioxidative transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway. However, DMF treatment in randomized controlled MS trials was associated with marked reductions in relapse rate and development of active brain MRI lesions, measures considered to reflect CNS inflammation...
April 26, 2016: Proceedings of the National Academy of Sciences of the United States of America
Steven K Lundy, Qi Wu, Qin Wang, Catherine A Dowling, Sophina H Taitano, Guangmei Mao, Yang Mao-Draayer
OBJECTIVE: To test the hypothesis that dimethyl fumarate (Tecfidera, BG-12) affects B-cell subsets in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: Peripheral blood B cells were compared for surface marker expression in patients with RRMS prior to initiation of treatment, after 4-6 months, and at more than 1 year of treatment with BG-12. Production of interleukin (IL)-10 by RRMS patient B cells was also analyzed. RESULTS: Total numbers of peripheral blood B lymphocytes declined after 4-6 months of BG-12 treatment, due to losses in both the CD27+ memory B cells and CD27(neg) B-cell subsets...
April 2016: Neurology® Neuroimmunology & Neuroinflammation
Ratul Kumar Das, Satinder Kaur Brar, Mausam Verma
Several lines of evidence have demonstrated the potential biomedical applications of fumaric acid (FA) and its ester derivatives against many human disease conditions. Fumaric acid esters (FAEs) have been licensed for the systemic treatment of the immune-mediated disease psoriasis. Biogen Idec Inc. announced about the safety and efficacy of the formulation FAE (BG-12) for treating RRMS (relapsing-remitting multiple sclerosis). Another FAE formulation DMF (dimethyl fumarate) was found to be capable of reduction in inflammatory cardiac conditions, such as autoimmune myocarditis and ischemia and reperfusion...
April 2016: Pharmacological Reports: PR
A Suneetha, K Raja Rajeswari
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS affecting both white and grey matter. Inflammation and oxidative stress are also thought to promote tissue damage in multiple sclerosis. Recent data point at an important role of anti-oxidative pathways for tissue protection in chronic MS, particularly involving the transcription factor nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2). Thus, novel therapeutics enhancing cellular resistance to free radicals could prove useful for MS treatment...
April 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Ruifeng Tian, Wenqing Yang, Qiang Xue, Liang Gao, Junli Huo, Dongqing Ren, Xiaoyan Chen
Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin an attractive candidate for diabetic complications. The present study was designed to investigate the potential effect of rutin on diabetic neuropathy. After induction of diabetic neuropathy, rutin (5mg/kg, 25mg/kg and 50mg/kg) were daily given to the diabetic rats for 2 weeks. At the end of rutin administration, rutin produced a significant inhibition of mechanical hyperalgesia, thermal hyperalgesia and cold allodynia, as well as partial restoration of nerve conduction velocities in diabetic rats...
January 15, 2016: European Journal of Pharmacology
Joseph D Smucker, Emily B Petersen, Ali Al-Hili, James V Nepola, Douglas C Fredericks
Chemotherapy derivatives of the rabbit posterolateral fusion model are considered a challenging environment in which to test bone graft materials. The purpose of this study was to determine the performance characteristics of SiCaP-30 as a bone graft substitute relative to autograft (iliac crest bone graft [ICBG]), Actifuse ABX and β-Tricalcium Phosphate-Bioactive Glass-Type I Collagen (βTCP-BG) in a rabbit posterolateral spine fusion model with concurrent chemotherapy treatment This was a randomized, controlled study in a laboratory setting with blinded assessment of fusion by manual palpation and flexibility testing...
2015: Iowa Orthopaedic Journal
Cíntia E Botton, Regis Radaelli, Eurico N Wilhelm, Anderson Rech, Lee E Brown, Ronei S Pinto
Botton, CE, Radaelli, R, Wilhelm, EN, Rech, A, Brown, LE, and Pinto, RS. Neuromuscular adaptations to unilateral vs. bilateral strength training in women. J Strength Cond Res 30(7): 1924-1932, 2016-Considering the bilateral deficit, the sum of forces produced by each limb in a unilateral condition is generally greater than that produced by them in a bilateral condition. Therefore, it can be speculated that performing unilateral strength exercises may allow greater training workloads and subsequently greater neuromuscular adaptations when compared with bilateral training...
July 2016: Journal of Strength and Conditioning Research
Takashi Tsunoda, Luis Fernando Chaves, Giang Thi Tra Nguyen, Yen Thi Nguyen, Masahiro Takagi
We studied the winter activity of Aedes albopictus (Skuse) from November 2008 to April 2009 in Bat Trang village of Hanoi, Vietnam. We selected 12 houses and collected: 1) adults with BG sentinel traps, 2) pupae from household water containers, and 3) eggs with ovitraps. Aedes albopictus adults, pupae, and eggs were not collected from early January to early February. Though the egg hatching probability tended to be initially high at longer day length, the maximum probability gradually shifted to shorter day length, as the observation period elapsed...
November 2015: Journal of Medical Entomology
Jin-Young Park, Im-Hee Jung, You-Kyoung Kim, Hyun-Chang Lim, Jung-Seok Lee, Ui-Won Jung, Seong-Ho Choi
BACKGROUND: In-vitro and animal studies using EDC cross-linked membranes have shown great resistance to enzymatic digestion as well as low cytotoxicity, and indicated its potential expediency as a barrier membrane for guided bone regeneration (GBR). The purpose of this study was to evaluate the efficacy, biocompatibility and degradation kinetics of a novel 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-cross-linked type I collagen membrane for regeneration of rabbit calvarial defects...
2015: Biomaterials Research
Shuai-Zhi Du, Guang-Hui Zhao, Jun-Feng Shao, Yan-Qin Fang, Ge-Ru Tian, Long-Xian Zhang, Rong-Jun Wang, Hai-Yan Wang, Meng Qi, San-Ke Yu
Non-human primates (NHPs) are confirmed as reservoirs of Cryptosporidium spp., Giardia intestinalis, and Enterocytozoon bieneusi. In this study, 197 fresh fecal samples from 8 NHP species in Qinling Mountains, northwestern China, were collected and examined using multilocus sequence typing (MLST) method. The results showed that 35 (17.8%) samples were positive for tested parasites, including Cryptosporidium spp. (3.0%), G. intestinalis (2.0%), and E. bieneusi (12.7%). Cryptosporidium spp. were detected in 6 fecal samples of Macaca mulatta, and were identified as C...
August 2015: Korean Journal of Parasitology
Lewis Macken, Oliver J Flower, Simon Bird, Naomi Hammond, Elizabeth Yarad, Frances Bass, Charles Fisher, Paul Strasma, Simon Finfer
PURPOSE: Variations in blood glucose (BG), hyperglycaemia and hypoglycaemia are associated with adverse clinical outcomes in intensive care unit patients. Continuous glucose monitoring (CGM) offers the potential to improve BG control, leading to improved patient outcomes. In our product development study, we determined the safety and performance of the GluCath Intravascular CGM System for up to 48 hours in 20 patients admitted to the ICU after cardiac surgery. METHODS: The GluCath system uses a quenched chemical fluorescence mechanism to optically measure glucose in blood...
September 2015: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
Kaushik Mukherjee, Kendell J Sowards, Steven E Brooks, Patrick R Norris, Judith M Jenkins, Miya A Smith, Paul M Bonney, Jeffrey B Boord, Addison K May
PURPOSE: Changes in insulin resistance (IR) cause stress-induced hyperglycemia after trauma, but the numerous factors involved in IR have not been delineated clearly. We hypothesized that a statistical model could help determine the relative contribution of different clinical co-variates to IR in critically injured patients. PATIENTS AND METHODS: We retrospectively studied 726 critically injured patients managed with a computer-assisted glycemic protocol at an academic level I trauma center (639 ventilated controls without pneumonia (VWP) and 87 patients with ventilator-associated pneumonia (VAP)...
October 2015: Surgical Infections
Napapon Sailasuta, Jintanat Ananworanich, Sukalaya Lerdlum, Pasiri Sithinamsuwan, James L K Fletcher, Somporn Tipsuk, Mantana Pothisri, Tanate Jadwattanakul, Supunnee Jirajariyavej, Thep Chalermchai, Stephanie Catella, Edgar Busovaca, Akash Desai, Robert Paul, Victor Valcour
OBJECTIVE: Combination antiretroviral therapy (cART) can suppress plasma HIV RNA to undetectable levels; yet reports indicate persistent HIV-associated neurocognitive disorders (HAND) among treated individuals. We sought to investigate imaging correlates of incomplete cognitive recovery among individuals with chronic HIV. METHODS: We used single voxel proton magnetic resonance spectroscopy in 4 regions of the brain to measure changes in neuronal and glia biomarkers in cART-naive subjects before (n = 59, 27 with HAND) and after 12 months of cART...
January 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Huaye Bao, Weisong Hong, Lifang Fu, Xiaodong Wei, Guopei Qian, Aie Xu
OBJECTIVES: To compare the efficacy of blister roof grafting (BG), cultured melanocytes transplantation (CMT) and non-cultured epidermal cell suspension transplantation (NCES) in the treatment of stable vitiligo. METHODS: In each person of 83 vitiligo patients one vitiligo macule was selected and divided in three areas for separate treatment with BG, CMT and NCES in the same session. The results were evaluated 12-month post-surgery for the extent of repigmentation and color match...
2015: Journal of Dermatological Treatment
Muhammad Khairud Dahri, Linda B L Lim, Chan Chin Mei
Cempedak durian peel (CDP) was used to remove Brilliant Green (BG) dye from aqueous solution. The adsorption of BG onto CDP was studied as functions of contact time, pH, temperature, ionic strength and initial concentration. In order to understand the adsorption process and its mechanisms, adsorption isotherm and kinetics models were used. The experiments were done under optimized 2-h contact time and ambient pH. Adsorption study showed that the Langmuir model best fitted with experimental data, and the maximum adsorption capacity was determined as 0...
August 2015: Environmental Monitoring and Assessment
Meghan R DuHadway, Claire R Sharp, Katherine E Meyers, Amy M Koenigshof
OBJECTIVE: To summarize the signalment, clinical signs, prevalence of decreased blood glucose concentration (BG), prevalence of increased liver values, treatment, and outcome in dogs known to have ingested xylitol. DESIGN: Retrospective study from December 2007 to February 2012 SETTING: Three university teaching hospitals. ANIMALS: One hundred ninety-two client-owned dogs with known or suspected xylitol ingestion. INTERVENTIONS: None...
September 2015: Journal of Veterinary Emergency and Critical Care
Jinhua Wei, Xiaona Li, Jianbo Gao
Glucose intolerance during pregnancy is defined as gestational diabetes mellitus (GDM). 95 women after 1 year birth were divided into GDM (n = 22), GIGT (gestational impaired glucose tolerance, n = 41) and NGT (normal, n = 32) groups. The GIGT group was subdivided into GIGT1 (abnormal blood glucose in 1 h, n = 11), GIGT2 (in 2 h, n = 18) and GIGT3 (in 3 h, n = 12) after oral glucose tolerance tests (OGTT). Compared with GIGT and NGT groups, GDM group showed higher FBG, 75 g OGTT 2 h BG, HOMA-IR, BMI, TCH, TG and LDL-C levels, while lower IFI...
2015: International Journal of Clinical and Experimental Medicine
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