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https://www.readbyqxmd.com/read/28328396/improved-medication-adherence-and-frequency-of-blood-glucose-self-testing-using-an-m-health-platform-versus-usual-care-in-a-multisite-randomized-clinical-trial-among-people-with-type-2-diabetes-in-india
#1
Nora J Kleinman, Avani Shah, Sanjiv Shah, Sanjeev Phatak, Vijay Viswanathan
BACKGROUND: In 2015, India had an estimated 69.2 million people with diabetes and a national prevalence of 8.7%. Evidence is mounting for the benefits of telemedicine in diabetes care, but remains limited on mobile-health (m-Health) interventions. INTRODUCTION: This study assessed the impact of an m-Health diabetes platform on clinical outcomes, patient-reported outcomes, patient and provider satisfaction, and app usage. MATERIALS AND METHODS: This open-label, two-arm parallel study enrolled 91 people at 3 sites in India, aged 18-65, with type 2 diabetes, and an A1c between 7...
March 6, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28317350/-effects-of-dentin-demineralization-and-bond-strength-properties-of-bioactive-glass-containing-resin-adhesive
#2
Wang Yu, Gong Ling, Ji Yan, Zheng Lichun, Chen Song
OBJECTIVE: This study investigated the shear bond strength and the ability of resin adhesive containing different amounts of bioactive glass (BG) to prevent dentin demineralization. METHODS: BG bonds at 30%, 40%, and 50% concentrations comprised a mixture of coupling agents modifying BG and Single Bond 2. Forty permanent premolars extracted for orthodontic treatment were randomly divided into four groups, namely, control group (BG-free), 30% BG group, 40% BG group, and 50% BG group...
August 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28296349/dipeptidyl-peptidase-4-inhibitors-as-preferable-oral-hypoglycemic-agents-in-terms-of-treatment-satisfaction-results-from-a-multicenter-12-week-open-label-randomized-controlled-study-in-japan
#3
Hitoshi Ishii, Yasuaki Hayashino, Yasuhiro Akai, Matahiro Yabuta, Satoru Tsujii
AIMS/INTRODUCTION: To compare the treatment satisfaction of four classes of oral hypoglycemic agents (OHAs): dipeptidyl peptidase-4 (DPP-4) inhibitors, α-glucosidase inhibitors (αGI), biguanides (BG), and sulfonylureas (SU), which are common initial treatments for type 2 diabetes mellitus patients in Japan, and to identify the best OHA in terms of treatment satisfaction. MATERIALS AND METHODS: In this 12-week, randomized, controlled, open-label study, Japanese outpatients with type 2 diabetes mellitus who were naïve to pharmacological treatment were randomly assigned a DPP-4 inhibitor, a BG, an αGI, or a SU...
March 14, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28287834/retrofitting-real-life-dexcom-g5-data
#4
Simone Del Favero, Andrea Facchinetti, Giovanni Sparacino, Claudio Cobelli
BACKGROUND: We proposed in 2014 a retrofitting algorithm to retrospectively increase the accuracy of continuous glucose monitoring (CGM) data by using some blood glucose (BG) measurements. The method proved effective on Dexcom SEVEN Plus when about 10 highly accurate YSI measurements/session were available. In this study, we test the method on Dexcom G5 sensor in a more realistic setup, where only five capillary BG measurements (self-monitoring blood glucose [SMBG]) per 12 h-session are available...
March 13, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28238154/the-gestio-protocol-experience-safety-of-a-standardized-order-set-for-subcutaneous-insulin-regimen-in-elderly-hospitalized-patients
#5
Alessandro Franchin, Alberto Maran, Daniela Bruttomesso, Maria L Corradin, Francesco Rossi, Federica Zanatta, Gian-Maria Barbato, Nicola Sicolo, Enzo Manzato
BACKGROUNDS: In non-critical hospitalized patients with diabetes mellitus, guidelines suggest subcutaneous insulin therapy with basal-bolus regimen, even in old and vulnerable inpatients. AIM: To evaluate safety, efficacy, and benefit on clinical management of the GesTIO protocol, a set of subcutaneous insulin administration rules, in old and vulnerable non-ICU inpatients. METHODS: Retrospective, observational study. Patients admitted to Geriatric Clinic of Padua were studied...
February 25, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28222207/impact-of-the-type-of-dialysis-membranes-on-the-circulating-concentration-of-markers-of-vitamin-d-metabolism
#6
Etienne Cavalier, Pablo U Torres, Bernard E Dubois, Nicole Smelten, Hans Pottel, Jean-Marie Krzesinski, Pierre Delanaye
INTRODUCTION: Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend vitamin D supplementation in hemodialyzed patients to monitor 25(OH)-vitamin D 25(OH)D levels. However, patient-to-patient inconsistency can be observed in response to the treatment. In this study, we aimed to evaluate the impact of the dialysis membrane on 25(OH)D, albumin (Alb) and vitamin D-binding protein (VDBP), the major players of vitamin D transport and storage. MATERIAL AND METHODS: Alb (Cobas), VDBP (R&D) and 25(OH)D (liquid chromatography-tandem mass spectrometry) were measured in 75 patients before and after a 4-hour dialysis session...
February 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28209654/replace-bg-a-randomized-trial-comparing-continuous-glucose-monitoring-with-and-without-routine-blood-glucose-monitoring-in-adults-with-well-controlled-type-1-diabetes
#7
Grazia Aleppo, Katrina J Ruedy, Tonya D Riddlesworth, Davida F Kruger, Anne L Peters, Irl Hirsch, Richard M Bergenstal, Elena Toschi, Andrew J Ahmann, Viral N Shah, Michael R Rickels, Bruce W Bode, Athena Philis-Tsimikas, Rodica Pop-Busui, Henry Rodriguez, Emily Eyth, Anuj Bhargava, Craig Kollman, Roy W Beck
OBJECTIVE: To determine whether the use of continuous glucose monitoring (CGM) without confirmatory blood glucose monitoring (BGM) measurements is as safe and effective as using CGM adjunctive to BGM in adults with well-controlled type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: A randomized noninferiority clinical trial was conducted at 14 sites in the T1D Exchange Clinic Network. Participants were ≥18 years of age (mean 44 ± 14 years), had T1D for ≥1 year (mean duration 24 ± 12 years), used an insulin pump, and had an HbA1c ≤9...
April 2017: Diabetes Care
https://www.readbyqxmd.com/read/28208421/thermodynamic-framework-for-the-ground-state-of-a-simple-quantum-system
#8
Andre M C Souza, Fernando D Nobre
The ground state of a two-level system (associated with probabilities p and 1-p, respectively) defined by a general Hamiltonian H[over ̂]=H[over ̂]_{0}+λV[over ̂] is studied. The simple case characterized by λ=0, whose Hamiltonian H[over ̂]_{0} is represented by a diagonal matrix, is well established and solvable within Boltzmann-Gibbs statistical mechanics; in particular, it follows the third law of thermodynamics, presenting zero entropy (S_{BG}=0) at zero temperature (T=0). Herein it is shown that the introduction of a perturbation λV[over ̂] (λ>0) in the Hamiltonian may lead to a nontrivial ground state, characterized by an entropy S[p] (with S[p]≠S_{BG}[p]), if the Hermitian operator V[over ̂] is represented by a 2×2 matrix, defined by nonzero off-diagonal elements V_{12}=V_{21}=-z, where z is a real positive number...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28192762/neural-mass-models-describing-possible-origin-of-the-excessive-beta-oscillations-correlated-with-parkinsonian-state
#9
Chen Liu, Yulin Zhu, Fei Liu, Jiang Wang, Huiyan Li, Bin Deng, Chris Fietkiewicz, Kenneth A Loparo
In Parkinson's disease, the enhanced beta rhythm is closely associated with akinesia/bradykinesia and rigidity. An increase in beta oscillations (12-35 Hz) within the basal ganglia (BG) nuclei does not proliferate throughout the cortico-basal ganglia loop in uniform fashion; rather it can be subdivided into two distinct frequency bands, i.e. the lower beta (12-20 Hz) and upper beta (21-35 Hz). A computational model of the excitatory and inhibitory neural network that focuses on the population properties is proposed to explore the mechanism underlying the pathological beta oscillations...
January 30, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28137708/an-alternative-sensor-based-method-for-glucose-monitoring-in-children-and-young-people-with-diabetes
#10
Julie Edge, Carlo Acerini, Fiona Campbell, Julian Hamilton-Shield, Chris Moudiotis, Shakeel Rahman, Tabitha Randell, Anne Smith, Nicola Trevelyan
OBJECTIVE: To determine accuracy, safety and acceptability of the FreeStyle Libre Flash Glucose Monitoring System in the paediatric population. DESIGN, SETTING AND PATIENTS: Eighty-nine study participants, aged 4-17 years, with type 1 diabetes were enrolled across 9 diabetes centres in the UK. A factory calibrated sensor was inserted on the back of the upper arm and used for up to 14 days. Sensor glucose measurements were compared with capillary blood glucose (BG) measurements...
January 30, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28132596/comparison-of-two-moldable-calcium-phosphate-based-bone-graft-materials-in-a-non-instrumented-canine-interspinous-implantation-model
#11
Davide Barbieri, Huipin Yuan, Ali Ismailoğlu, Joost de Bruijn
There is a continuing search for novel synthetic materials as an alternative to autologous bone grafting. Different technologies are explored to promote bone formation, which include the addition of BioGlassTM particles in calcium phosphate (CaP) based materials and the use of surface modification in the form of submicron surface topographies. In this work we aimed at comparing the bone formation in a non-instrumented canine interspinous (IS) model of moldable formulations of a submicron surface structured tricalcium phosphate/alkylene oxide (CaP/AOC) or a tricalcium phosphate/BioGlassTM/collagen (CaP/BG/C) bone graft material...
January 28, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28107866/potential-of-zimbabwean-commercial-probiotic-products-and-strains-of-lactobacillus-plantarum-as-prophylaxis-and-therapy-against-diarrhoea-caused-by-escherichia-coli-in-children
#12
Walter Chingwaru, Jerneja Vidmar
OBJECTIVE: To evaluate the potential of commercial fermented products sold in the country, and strains of Lactobacillus plantarum (L. plantarum) as prophylaxis and therapy against diarrhoea in children. METHODS: The antimicrobial potential of cultures of lactobacilli enriched from 4 Zimbabwean commercial food/beverage products: Dairibord Lacto sour milk (DLSM), Probrand sour milk (PSM), Kefalos Vuka cheese (KVC) and Chibuku opaque beer (COB); and four strains of L...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28012366/influence-of-low-level-laser-therapy-on-the-healing-process-of-autogenous-bone-block-grafts-in-the-jaws-of-systemically-nicotine-modified-rats-a-histomorphometric-study
#13
Juliano Milanezi de Almeida, Ricardo Oliveira de Moraes, David Jonathan Rodrigues Gusman, Paula Lazilha Faleiros, Maria José Hitomi Nagata, Valdir Gouveia Garcia, Letícia Helena Theodoro, Alvaro Francisco Bosco
OBJECTIVE: To analyze the influence of low-level laser therapy (LLLT) on the bone healing process of autogenous bone block grafts installed in nicotine systemically modified rats. METHODS: Seventy-two rats (Wistar) were randomly assigned into 4 groups (n=18). SS-BG: saline application+bone graft. SS-BG/LLLT: saline application+bone graft+LLLT. NIC-BG: nicotine application+bone graft. NIC-BG/LLLT: nicotine application+bone graft+LLLT. After 30days of application of solutions, all animals received autogenous bone block graft in the jaw, with the donation from the parietal bone's calvarial area...
December 5, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/28004333/the-relationship-between-the-decreased-rate-of-initial-blood-glucose-and-neurologic-outcomes-in-survivors-of-out-of-hospital-cardiac-arrest-receiving-therapeutic-hypothermia
#14
Jae-Hyug Woo, Yong Su Lim, Hyuk Jun Yang, Sung Youl Hyun, Jin Seong Cho, Jin Joo Kim, Gun Lee
BACKGROUND: Hyperglycemia in out-of-hospital cardiac arrest (OHCA) survivors is associated with poor outcomes. However, in the control of initial hyperglycemia, an adequate strategy to improve patients' neurologic outcomes remains undetermined. Prior to the establishment of such strategy, we need to determine whether a decreased rate of initial blood glucose (BG) affects patient outcomes. METHODS: One hundred and forty-five adult non-traumatic OHCA survivors treated with therapeutic hypothermia between April 2007 and December 2011 were enrolled in this single-center retrospective cohort study...
December 21, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27967226/use-of-a-computer-guided-glucose-management-system-to-improve-glycemic-control-and-address-national-quality-measures-a-7-year-retrospective-observational-study-at-a-tertiary-care-teaching-hospital
#15
Robert J Tanenberg, Sandra Hardee, Caitlin Rothermel, Almond J Drake
OBJECTIVE: Inpatient hyperglycemia, hypoglycemia, and glucose variability are associated with increased mortality. The use of an electronic glucose management system (eGMS) to guide intravenous (IV) insulin infusion has been found to significantly improve blood glucose (BG) control. This retrospective observational study evaluated the 7-year (January 2009-December 2015) impact of the EndoTool(®) eGMS in intensive and intermediate units at Vidant Medical Center, a 900-bed tertiary teaching hospital...
March 2017: Endocrine Practice
https://www.readbyqxmd.com/read/27894743/transfer-factors-for-natural-radioactivity-into-date-palm-pits
#16
Mohammad Abu Shayeb, Thamer Alharbi, Muzahir Ali Baloch, Omar Abdul Rahman Alsamhan
Palm pits are used in various human and animal feed products. In this study, the natural radioactivity levels from soil and date palm pits of 9 samples collected from major date palm farms in three different regions (Buraidah, Al-Zulfi and Al-Majmaah) of Saudi Arabia were determined by using the high purity germanium (HPGe) gamma-ray spectrometer. The mean activity concentrations of (226)Ra, (232)Th, (137)Cs and (40)K in soil samples were 12.8 ± 2.2, 10.2 ± 2.1, 0.28 ± 0.10 and 329 ± 87 Bg kg(-1), respectively...
February 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/27887721/comparative-multimodal-meta-analysis-of-structural-and-functional-brain-abnormalities-in-autism-spectrum-disorder-and-obsessive-compulsive-disorder
#17
Christina O Carlisi, Luke J Norman, Steve S Lukito, Joaquim Radua, David Mataix-Cols, Katya Rubia
BACKGROUND: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share inhibitory control deficits possibly underlying poor control over stereotyped and repetitive and compulsive behaviors, respectively. However, it is unclear whether these symptom profiles are mediated by common or distinct neural profiles. This comparative multimodal meta-analysis assessed shared and disorder-specific neuroanatomy and neurofunction of inhibitory functions. METHODS: A comparative meta-analysis of 62 voxel-based morphometry and 26 functional magnetic resonance imaging (fMRI) studies of inhibitory control was conducted comparing gray matter volume and activation abnormalities between patients with ASD (structural MRI: 911; fMRI: 188) and OCD (structural MRI: 928; fMRI: 247) and control subjects...
October 13, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27884157/manual-versus-automated-monitoring-accuracy-of-glucose-ii-manage-ii
#18
Cláudia Righy Shinotsuka, Alexandre Brasseur, David Fagnoul, Timothy So, Jean-Louis Vincent, Jean-Charles Preiser
BACKGROUND: Intravascular continuous glucose monitoring (CGM) may facilitate glycemic control in the intensive care unit (ICU). We compared the accuracy of a CGM device (OptiScanner®) with a standard reference method. METHODS: Adult patients who had blood glucose (BG) levels >150 mg/dl and required insertion of an arterial and central venous catheter were included. The OptiScanner® was inserted into a multiple-lumen central venous catheter. Patients were treated using a dynamic-scale insulin algorithm to achieve BG values between 80 and 150 mg/dl...
November 25, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27875061/glycemic-control-reduces-infections-in-post-liver-transplant-patients-results-of-a-prospective-randomized-study
#19
Amisha Wallia, Kathleen Schmidt, Diana Johnson Oakes, Teresa Pollack, Nicholas Welsh, Susan Kling-Colson, Suruchi Gupta, Candice Fulkerson, Grazia Aleppo, Neehar Parikh, Josh Levitsky, J P Norvell, Alfred Rademaker, Mark E Molitch
CONTEXT: Prior studies have shown a relationship between glycemic control and post-transplant morbidity. OBJECTIVE: We conducted a prospective randomized controlled trial in post liver transplant patients, evaluating intensive inpatient glycemic control and effects on outcomes to 1 year. Research Design and Intervention: 164 patients (blood glucose (BG) > 180 mg/dL) were randomized to two target groups: BG 140 mg/dL (N= 82) and 180 mg/dL (N= 82). Patients were initiated on insulin drips and then converted to subcutaneous basal bolus insulin therapy by our Glucose Management Service...
November 22, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27832978/current-practice-of-hypoglycemia-management-in-the-ed
#20
Matthew H Bilhimer, Cierra N Treu, Nicole M Acquisto
PURPOSE: To characterize hypoglycemia management and identify characteristics associated with refractory (need for additional treatment following initial management) and recurrent (adequate initial treatment followed by blood glucose [BG] ≤50 mg/dL) hypoglycemia. METHODS: Retrospective review of adult emergency department (ED) patients who presented to a large academic medical center with hypoglycemia (BG ≤ 50 mg/dL) between January 2011 and July 2015. Data collection focused on BG measurements and treatment practices...
January 2017: American Journal of Emergency Medicine
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