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https://www.readbyqxmd.com/read/27898732/chemokine-levels-in-the-penile-coronal-sulcus-correlate-with-hiv-1-acquisition-and-are-reduced-by-male-circumcision-in-rakai-uganda
#1
Jessica L Prodger, Ronald H Gray, Brett Shannon, Kamnoosh Shahabi, Xiangrong Kong, Kate Grabowski, Godfrey Kigozi, Fred Nalugoda, David Serwadda, Maria J Wawer, Steven J Reynolds, Cindy M Liu, Aaron A R Tobian, Rupert Kaul
Individual susceptibility to HIV is heterogeneous, but the biological mechanisms explaining differences are incompletely understood. We hypothesized that penile inflammation may increase HIV susceptibility in men by recruiting permissive CD4 T cells, and that male circumcision may decrease HIV susceptibility in part by reducing genital inflammation. We used multi-array technology to measure levels of seven cytokines in coronal sulcus (penile) swabs collected longitudinally from initially uncircumcised men enrolled in a randomized trial of circumcision in Rakai, Uganda...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27897119/glaucoma-hot-topics-in-pharmacology
#2
Shiama I Balendra, Parth Arvind Shah, Mishank Jain, Andrzej Grzybowski, Francesca M Cordeiro
BACKGROUND: Glaucoma comprises a group of neurodegenerative diseases resulting in retinal ganglion cell death within the optic nerve head. It is projected to affect almost 80 million people worldwide by 2020. The condition's asymptomatic nature translates to over half of glaucoma sufferers being unaware of their condition. By the time of diagnosis, irreversible blindness is likely to have occurred. Prime areas of glaucoma research therefore include identification and optimization of risk factors for the disease, accurate and early diagnostic tools and novel therapeutic methods...
November 29, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27882863/porphyromonas-gingivalis-suppresses-adaptive-immunity-in-periodontitis-atherosclerosis-and-alzheimer-s-disease
#3
REVIEW
Ingar Olsen, Martin A Taubman, Sim K Singhrao
Porphyromonas gingivalis, a keystone pathogen in chronic periodontitis, has been found to associate with remote body organ inflammatory pathologies, including atherosclerosis and Alzheimer's disease (AD). Although P. gingivalis has a plethora of virulence factors, much of its pathogenicity is surprisingly related to the overall immunosuppression of the host. This review focuses on P. gingivalis aiding suppression of the host's adaptive immune system involving manipulation of cellular immunological responses, specifically T cells and B cells in periodontitis and related conditions...
2016: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/27881337/-inhibitory-effect-of-mig-7-silencing-by-retrovirus-mediated-shrna-on-vasculogenic-mimicry-invasion-and-metastasis-of-human-hepatocellular-carcinoma-cells-in-vitro
#4
Bo Qu, Guan-Nan Sheng, Fei Yu, Guan-Nan Chen, Qi Lv, Zhong-Peng Mao, Long Guo, Yi Lv
OBJECTIVE: To explore the inhibitory effect of migration-inducing gene 7 (Mig-7) gene silencing induced by retroviral-mediated small hairpin RNA (shRNA) on vasculogenic mimicry (VM), invasion and metastasis of human hepatocellular carcinoma (HCC) cells in vitro. METHODS: Two target sequences (Mig-7 shRNA-1 and Mig-7 shRNA-2) and one negative control sequence (Mig-7 shRNA-N) were synthesized. The recombinant retroviral vectors carrying Mig-7 shRNA were constructed, and HCC cell line MHCC-97H were transfected with Mig-7 shRNA-1, Mig-7 shRNA-2, Mig-7 shRNA-N, or the empty vector, or treated with 125 µg/mL recombinant human endostatin (ES)...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27852671/highly-multiplexed-proteomic-analysis-of-quantiferon-supernatants-to-identify-biomarkers-of-latent-tuberculosis-infection
#5
Mary Ann De Groote, Michael Higgins, Thomas Hraha, Kirsten Wall, Michael L Wilson, David G Sterling, Nebojsa Janjic, Randall Reves, Urs A Ochsner, Robert Belknap
The tests for diagnosing latent tuberculosis infection (LTBI) are limited by poor predictive value for identifying people at highest risk for progression to active TB, and have varying sensitivity and specificity in different populations. The identification of a more robust signature for LTBI is important for TB prevention and elimination. A pilot study was conducted with samples from immigrants to the U.S. that were screened for LTBI by the three commercially approved tests: Tuberculin Skin Test (TST), QuantiFERON-TB Gold In-Tube (QFT-GIT), and T-SPOT...
November 16, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27848022/is-there-a-change-in-the-quality-of-life-comparing-the-micro-invasive-glaucoma-surgery-migs-and-the-filtration-technique-trabeculectomy-in-glaucoma-patients
#6
Milena Pahlitzsch, Matthias K J Klamann, Marie-Luise Pahlitzsch, Johannes Gonnermann, Necip Torun, Eckart Bertelmann
PURPOSE: This study was conducted to assess the impact on the Quality of Life (QOL) of micro-invasive glaucoma surgery (MIGS: iStent, Trabectome) and a penetrating technique such as Trabeculectomy (TE). METHODS: This study evaluated 88 eyes of 88 open angle glaucoma patients undergoing glaucoma surgery: 43 (mean age 72.8 ± 8.8y, female 59.5 %, male 40.5 %) Trabectome (NeoMedix, Inc., Tustin, CA, USA), 20 (mean age 68.6 ± 16.4y, female 60 %, male 40 %) iStent (Glaucos Corporation, Laguna Hills, CA, USA), and 25 TE patients (mean age 74...
November 15, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27845488/contact-dermatitis-and-interferon-%C3%AE-dependent-chemokines
#7
P Fallahi, I Ruffilli
Inflammation of the skin is the pathological base of contact dermatitis (CD), and cytokines are very important in its pathogenesis. Recently it has been shown that interferon (IFN)-γ, and the IFN-γ dependent chemokines, monokine induced by IFN-γ (MIG), IFN-γ-induced protein 10 (IP-10), and IFN-inducible T cell alpha chemoattractant (I-TAC), play an important role in CD. Allergic CD (ACD) is a T-cell-mediated disease in which expression of a distinct repertoire of chemokines results in the recruitment of effector T cells into the skin...
September 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27815624/contralateral-eye-comparison-study-in-mics-migs-trabectome%C3%A2-vs-istent-inject%C3%A2
#8
Johannes Gonnermann, Eckart Bertelmann, Milena Pahlitzsch, Anna-Karina B Maier-Wenzel, Necip Torun, Matthias K J Klamann
PURPOSE: To compare the safety and efficacy profile after combined micro-incision cataract surgery (MICS) and micro-invasive glaucoma surgery (MIGS) with the ab interno trabeculectomy (Trabectome®) in one eye versus two iStent® inject devices in the contralateral eye in patients with open-angle glaucoma (OAG) and cataract. METHODS: This retrospective, intraindividual eye comparison study included 27 patients (54 eyes) who were treated with combined MICS and ab interno trabeculectomy (group I, Trabectome®) in one eye and two iStent® inject devices (group II, GTS 400) in the fellow eye...
November 4, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27813377/metabolic-syndrome-and-the-seminal-cytokine-network-in-morbidly-obese-males
#9
A Pilatz, C Hudemann, J Wolf, I Halefeld, A Paradowska-Dogan, H-C Schuppe, H Hossain, Q Jiang, D Schultheiss, H Renz, W Weidner, F Wagenlehner, T Linn
Given the increasing prevalence of metabolic syndrome (MetS) in males of reproductive age, the objective of this prospective case-controlled study was to investigate the impact of subacute systemic inflammation associated with MetS on seminal cytokines and standard sperm parameters in comparison with healthy men. Between 2011 and 2014, we recruited 27 patients with MetS out of 41 obese patients screened from an internal outpatient clinic. Twenty-seven age-matched healthy controls were enrolled from 54 men requesting vasectomy in a urological outpatient clinic...
November 3, 2016: Andrology
https://www.readbyqxmd.com/read/27799846/characterization-of-a-thermostable-8-oxoguanine-dna-glycosylase-specific-for-go-n-mismatches-from-the-thermoacidophilic-archaeon-thermoplasma-volcanium
#10
Miki Fujii, Chieri Hata, Munetada Ukita, Chie Fukushima, Chihiro Matsuura, Yoshie Kawashima-Ohya, Koji Tomobe, Tsuyoshi Kawashima
The oxidation of guanine (G) to 7,8-dihydro-8-oxoguanine (GO) forms one of the major DNA lesions generated by reactive oxygen species (ROS). The GO can be corrected by GO DNA glycosylases (Ogg), enzymes involved in base excision repair (BER). Unrepaired GO induces mismatched base pairing with adenine (A); as a result, the mismatch causes a point mutation, from G paired with cytosine (C) to thymine (T) paired with adenine (A), during DNA replication. Here, we report the characterization of a putative Ogg from the thermoacidophilic archaeon Thermoplasma volcanium...
2016: Archaea: An International Microbiological Journal
https://www.readbyqxmd.com/read/27788725/-inhibitory-effect-of-migration-inducing-gene-7-shrna-recombinant-retrovirus-combined-with-endostatin-on-growth-and-metastasis-of-hepatoma-xenograft
#11
B Qu, G N Chen, G N Sheng, F Yu, Q Lyu, Y J Gu, L Guo, Y Lyu
Objective: To investigate the inhibitory effect of migration-inducing gene-7(Mig-7)interfered with retrovirus-mediated RNA(shRNA)combined with recombinant human endostatin(ES)on the growth and metastasis of subcutaneous xenograft of human hepatoma cells in nude mice. Methods: Two Mig-7-mRNA oligonucleotide sequences(Mig-7-shRNA-1 and Mig-7-shRNA-2)and one sequence as a negative control(Mig-7-shRNA-N)were designed. The specific Mig-7-shRNA recombinant retrovirus expression vector plasmid was constructed and used for the transfection of human hepatoma MHCC-97H cells with high expression of Mig-7...
September 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27780040/functional-coordination-of-wave-and-wasp-in-c-%C3%A2-elegans-neuroblast-migration
#12
Zhiwen Zhu, Yongping Chai, Yuxiang Jiang, Wenjing Li, Huifang Hu, Wei Li, Jia-Wei Wu, Zhi-Xin Wang, Shanjin Huang, Guangshuo Ou
Directional cell migration is critical for metazoan development. We define two molecular pathways that activate the Arp2/3 complex during neuroblast migration in Caenorhabditis elegans. The transmembrane protein MIG-13/Lrp12 is linked to the Arp2/3 nucleation-promoting factors WAVE or WASP through direct interactions with ABL-1 or SEM-5/Grb2, respectively. WAVE mutations partially impaired F-actin organization and decelerated cell migration, and WASP mutations did not inhibit cell migration but enhanced migration defects in WAVE-deficient cells...
October 24, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27757562/a-case-series-of-rem-sleep-behavior-disorder-in-pure-autonomic-failure
#13
Mitchell G Miglis, Srikanth Muppidi, Emmanuel During, Safwan Jaradeh
PURPOSE: Data on the prevalence of RBD in patients with PAF are limited, with discrepancies in the literature regarding prevalence. We aimed to provide further data on this association with a series of eight patients with PAF. METHODS: We reviewed the electronic medical records of all patients seen at the Stanford neurology clinics from 2012 to 2016 who were given a provisional diagnosis of PAF (343 patients), and further screened by procedure codes to identify those patients who underwent both attended video-polysomonography and autonomic testing (18 patients), and met strict exclusionary criteria (8 patients)...
October 18, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27730028/prevalence-of-cmv-infection-among-staff-in-a-metropolitan-children-s-hospital-occupational-health-screening-findings
#14
Johanna Stranzinger, Jutta Kindel, Melanie Henning, Dana Wendeler, Albert Nienhaus
Background: Staff in children's hospitals may run an increased risk of cytomegalovirus (CMV) contact infection leading to a congenital CMV fetopathy during pregnancy. The main risk factor is close contact with inapparent carriers of CMV among infants (<3 years). We therefore examined CMV seroprevalence (SP) and possible risk factors for CMV infection among staff at a children's hospital. Method: In 2014, staff at a metropolitan children's hospital were offered a CMV antibody test in the context of occupational health screening...
2016: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/27728942/biosurgicals-and-the-minimally-invasive-gynecologic-surgery-migs-surgeon
#15
James Dana Kondrup, Frances R Anderson, Melanie Rose Katz
Biosurgical materials (biosurgicals) have a wide array of uses for providing hemostasis, including decreasing the risk of postoperative bleeding and, intraoperatively, controling bleeding. These materials are especially useful in situations where electrocautery, sutures, or clips are not feasible. Biosurgicals have long been used in general surgery and surgical subspecialties to provide hemostasis; however, they still are not commonly used during obstetric and gynecologic procedures. Three commonly used classes of biosurgicals will be discussed in this article: oxidized regenerated cellulose, flowables, fibrin sealants, and fibrin sealant patches...
October 6, 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27726283/survey-of-glaucoma-surgical-preferences-and-post-operative-care-in-the-united-kingdom
#16
Ignacio Rodriguez-Una, Augusto Azuara-Blanco, Anthony J King
BACKGROUND: To evaluate the spectrum of glaucoma surgery and the post-operative follow-up regimes undertaken among glaucoma specialists in the United Kingdom. DESIGN: National survey. PARTICIPANTS: Seventy-five glaucoma specialists (consultants and fellows). METHODS: An eight-question survey was emailed to all glaucoma subspecialists members of the United Kingdom and Eire Glaucoma Society. MAIN OUTCOME MEASURES: Surgery undertaken, post-operative management, awareness of intervention tariff and handling of the follow-up burden generated through surgery...
October 11, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27721433/synergistic-communication-between-cd4-t-cells-and-monocytes-impacts-the-cytokine-environment
#17
Sarah B Schrier, Abby S Hill, Deborah Plana, Douglas A Lauffenburger
Physiological cytokine environments arise from factors produced by diverse cell types in coordinated concert. Understanding the contributions of each cell type in the context of cell-cell communication is important for effectively designing disease modifying interventions. Here, we present multi-plexed measurement of 48 cytokines from a coculture system of primary human CD4+ T cells and monocytes across a spectrum of stimuli and for a range of relative T cell/monocyte compositions, coupled with corresponding measurements from PBMCs and plasma from the same donors...
October 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27686565/evolving-surgical-interventions-in-the-treatment-of-glaucoma
#18
Courtney E Bovee, Louis R Pasquale
Interventions in the treatment of mild to moderate glaucoma have evolved to include a group of procedures collectively named "Minimally Invasive Glaucoma Surgery (MIGS)." These procedures are less invasive than traditional filtering surgery and setons and offer the benefit of an improved side-effect profile. A review of current published literature has shown that these procedures offer lower intraocular pressure, decrease reliance on topical medications, have no negative effect on refractive outcomes, and can be safely done following failed tube surgery...
September 29, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27684945/oral-administration-of-antioxidants-improves-skin-wound-healing-in-diabetic-mice
#19
Ana Flávia Marçal Pessoa, Juliana Costa Florim, Hosana Gomes Rodrigues, Vinicius Andrade-Oliveira, Simone A Teixeira, Kaio Fernando Vitzel, Rui Curi, Niels Olsen Saraiva Câmara, Marcelo N Muscará, Marcelo Lazzaron Lamers, Marinilce Fagundes Santos
Oxidative stress aggravates several long-term complications in diabetes mellitus. We evaluated the effectiveness of the oral administration of antioxidants (vitamins E and C, 40 and 100 mg/kg b.w., respectively) on skin wound healing acceleration in alloxan-induced diabetic mice. Mice were wounded 30 days after the induction of diabetes. Antioxidants were effective in preventing oxidative stress, as assessed by TBARS. The enzymes catalase, glutathione reductase, glutathione peroxidase, and superoxide dismutase were increased in diabetics on the 3rd day post-wounding; catalase and glutathione peroxidase remained still augmented in diabetics after 14th day postwounding, and the treatment with vitamins restored their activities to control...
September 29, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27678756/now-you-see-it-using-a-30%C3%A2-laparoscope-for-migs
#20
J D Kondrup, B A Sylvester, M L Branning
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
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