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https://www.readbyqxmd.com/read/28327447/effect-of-motivational-interviewing-on-depression-scale-scores-of-adolescents-with-obesity-and-overweight
#1
Silvia Freira, Marina Serra Lemos, Geoffrey Williams, Marta Ribeiro, Fernanda Pena, Maria do Céu Machado
The aim of this study was to compare the effect of motivational interview (MI) with conventional care on the depression scale scores of adolescents with obesity/overweight. It was a controlled cluster randomized trial with parallel design, including two groups: intervention group [Motivational Interview Group (MIG)], control group [Conventional Intervention Group (CIG)]. INTERVENTION: three face-to-face 30min' interviews three months apart (only MIG interviews were based on MI principles)...
March 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28302021/cytokines-induced-during-influenza-virus-infection
#2
Tatiana Betáková, Anna Kostrabova, Veronika Lachova, Lucia Turianova
Influenza A virus is one of the major human pathogens. The influenza infection can pass out without any subclinical symptoms or infestation can appear in upper respiratory tract as well as in lower respiratory tract where it can result in lethal outcome. Both innate and adaptive immune responses are activated shortly after infection providing protection against infection. Many activities of the cells of innate and adaptive immunity are coordinated by cytokines. However, inordinate or disbalanced immune response may result in overproduction of cytokines as well as chemokines what can lead to severe inflammation, including excessive recruitment of neutrophils and mononuclear cells at the site of infection...
March 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28274320/-circulating-levels-of-th1-and-th2-chemokines-increase-in-patients-with-early-syphilis
#3
Anyou Zhu, Chenchen Wang, Hong Sun, Hongfang Han, Fengchao Wang, Lunjun Zhang, Jianguo Hu
Objective To study the changes of plasma T helper type I (Th1)-and Th2-chemokine levels and analyze their roles in immune response and pathogenesis of early syphilis. Methods Heparin-anticoagulated peripheral blood was collected from 56 patients with early syphilis (primary syphilis, PS, n=22; secondary syphilis, SS, n=34) and healthy controls (HC, n=20). The levels of plasma Th1 chemokines including monokine induced by interferon-γ (MIG), interferon-γ inducible protein-10 (IP-10), interferon-inducible T-cell α chemoattractant (I-TAC) and Th2 chemokines including thymus-and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) were examined using ELISA...
March 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28255741/is-pure-autonomic-failure-an-early-marker-for-parkinson-disease-dementia-with-lewy-bodies-and-multiple-system-atrophy-and-other-updates-on-recent-autonomic-research
#4
EDITORIAL
Srikanth Muppidi, Mitchell G Miglis
No abstract text is available yet for this article.
March 2, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28254558/early-serum-biomarker-networks-in-infants-with-distinct-retinochoroidal-lesion-status-of-congenital-toxoplasmosis
#5
Thádia Evelyn de Araújo, Jordana Grazziela Coelho-Dos-Reis, Samantha Ribeiro Béla, Ana Carolina Aguiar Vasconcelos Carneiro, Anderson Silva Machado, Ludmila Melo Cardoso, Ágata Lopes Ribeiro, Michelle Hallais França Dias, Gláucia Manzan Queiroz Andrade, Daniel Vitor Vasconcelos-Santos, José Nélio Januário, Andréa Teixeira-Carvalho, Ricardo Wagner Almeida Vitor, Eloisa Amália Vieira Ferro, Olindo Assis Martins-Filho
The present study characterized the early changes in the serum chemokines/cytokine signatures and networks in infants with congenital-toxoplasmosis/(TOXO) as compared to non-infected-controls/(NI). TOXO were subgrouped according to the retinochoroidal lesion status as no-lesion/(NL), active-lesion/(ARL), active/cicatricial-lesion/(ACRL) and cicatricial-lesion/(CRL). The results showed that TOXO display prominent chemokine production mediated by IL-8/CXCL8, MIG/CXCL9, IP-10/CXCL10 and RANTES/CCL5. Additionally, TOXO is accompanied by mixed proinflammatory/regulatory cytokine pattern mediated by IL-6, IFN-γ, IL-4, IL-5 and IL-10...
February 28, 2017: Cytokine
https://www.readbyqxmd.com/read/28240764/allergic-rhinitis-and-cxcr3-chemokines
#6
V Mazzi, P Fallahi
The underlying mechanism of allergic rhinitis involves IgE antibodies attaching to the allergen and causing the release of inflammatory chemicals such as histamine from mast cells. Cytokines are very important in this process. Many data suggest a systemic shift to more intensely type 1-dominated immune responses in non-allergic individuals and, conversely, to more type 2-dominated responses in allergic individuals upon natural re-exposure to grass pollen. However other studies have found that chemokine (C-X-C motif) ligand (CXCL)10/ interferon (IFN)-γ-induced protein 10 (IP-10) and CXCL9/monokine induced by IFN-γ (MIG) concentrations are elevated in nasal lavages from allergic patients suggesting that these chemokines may play a role in chronic allergic inflammation...
January 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28240761/hepatocellular-carcinoma-and-cxcr3-chemokines-a-narrative-review
#7
E Giusy, F Poupak
Hepatocellular carcinoma (HCC) results from several factors like viral hepatitis infection [hepatitis B, or C (25%)] or occupational exposure. T-helper (Th)1 inflammatory cells, characterized by interferon (IFN)-γ and interleukin (IL)-2 secretion, predominate in the liver during chronic HCV infection, and chemokines attracting these cells are particularly important in disease progression. Among C-X-C chemokines, the non-ELR group [as IFN-γ-induced protein 10 (IP-10), monokine induced by IFN-γ (MIG) and IFN-inducible T-cell-alpha chemoattractant (I-TAC)], attracts Th1-cells interacting with chemokine C-X-C receptor (CXCR3)...
January 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28185027/safety-and-feasibility-of-minimally-invasive-gastrectomy-during-the-early-introduction-in-the-netherlands-short-term-oncological-outcomes-comparable-to-open-gastrectomy
#8
H J F Brenkman, J P Ruurda, R H A Verhoeven, R van Hillegersberg
BACKGROUND: Minimally invasive techniques for gastric cancer surgery have recently been introduced in the Netherlands, based on a proctoring program. The aim of this population-based cohort study was to evaluate the short-term oncological outcomes of minimally invasive gastrectomy (MIG) during its introduction in the Netherlands. METHODS: The Netherlands Cancer Registry identified all patients with gastric adenocarcinoma who underwent gastrectomy with curative intent between 2010 and 2014...
February 9, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28167306/non-receptor-type-proline-rich-protein-tyrosine-kinase-2-pyk2-is-a-possible-therapeutic-target-for-kawasaki-disease
#9
Chinatsu Suzuki, Akihiro Nakamura, Noriko Miura, Kuniyoshi Fukai, Naohito Ohno, Tomoyo Yahata, Akiko Okamoto-Hamaoka, Maiko Fujii, Ayako Yoshioka, Yuki Kuchitsu, Kazuyuki Ikeda, Kenji Hamaoka
Kawasaki disease (KD) is a paediatric vasculitis whose pathogenesis remains unclear. Based on experimental studies using a mouse model for KD, we report here that proline-rich protein tyrosine kinase 2 (Pyk2) plays a critical role in the onset of KD-like murine vasculitis. The mouse model for KD was prepared by administrating a Candida albicans water-soluble fraction (CAWS). Unlike CAWS-treated WT mice, CAWS-treated Pyk2-Knockout (Pyk2-KO) mice did not develop apparent vasculitis. A sustained increase in MIG/CXCL9 and IP-10/CXCL10, both of which have potent angiostatic activity, was observed in CAWS-treated Pyk2-KO mice...
February 3, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28154511/effects-of-single-nucleotide-polymorphism-marker-density-on-haplotype-block-partition
#10
Sun Ah Kim, Yun Joo Yoo
Many researchers have found that one of the most important characteristics of the structure of linkage disequilibrium is that the human genome can be divided into non-overlapping block partitions in which only a small number of haplotypes are observed. The location and distribution of haplotype blocks can be seen as a population property influenced by population genetic events such as selection, mutation, recombination and population structure. In this study, we investigate the effects of the density of markers relative to the full set of all polymorphisms in the region on the results of haplotype partitioning for five popular haplotype block partition methods: three methods in Haploview (confidence interval, four gamete test, and solid spine), MIG++ implemented in PLINK 1...
December 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/28148822/transcriptional-responses-to-hyperplastic-mrl-signalling-in-drosophila
#11
Vincent Jonchère, Nada Alqadri, John Herbert, Lauren Dodgson, David Mason, Giovanni Messina, Francesco Falciani, Daimark Bennett
Recent work has implicated the actin cytoskeleton in tissue size control and tumourigenesis, but how changes in actin dynamics contribute to hyperplastic growth is still unclear. Overexpression of Pico, the only Drosophila Mig-10/RIAM/Lamellipodin adapter protein family member, has been linked to tissue overgrowth via its effect on the myocardin-related transcription factor (Mrtf), an F-actin sensor capable of activating serum response factor (SRF). Transcriptional changes induced by acute Mrtf/SRF signalling have been largely linked to actin biosynthesis and cytoskeletal regulation...
February 2017: Open Biology
https://www.readbyqxmd.com/read/28120845/association-of-hpv-infection-and-clearance-with-cervicovaginal-immunology-and-the-vaginal-microbiota
#12
B Shannon, T J Yi, S Perusini, P Gajer, B Ma, M S Humphrys, J Thomas-Pavanel, L Chieza, P Janakiram, M Saunders, W Tharao, S Huibner, K Shahabi, J Ravel, A Rebbapragada, R Kaul
Cervical human papillomavirus (HPV) infection may increase HIV risk. Since other genital infections enhance HIV susceptibility by inducing inflammation, we assessed the impact of HPV infection and clearance on genital immunology and the cervico-vaginal microbiome. Genital samples were collected from 65 women for HPV testing, immune studies and microbiota assessment; repeat HPV testing was performed after 6 months. All participants were HIV-uninfected and free of bacterial STIs. Cytobrush-derived T cell and dendritic cell subsets were assessed by multiparameter flow cytometry...
January 25, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28108826/the-sacral-parasympathetic-system-is-actually-sympathetic-and-other-updates-on-recent-autonomic-research
#13
EDITORIAL
Mitchell G Miglis, Srikanth Muppidi
No abstract text is available yet for this article.
January 20, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28100872/serum-monokine-induced-by-gamma-interferon-is-associated-with-severity-of-coronary-artery-disease
#14
Youfeng Liang, Chun Yang, Qi Zhou, Wenbo Pan, Wansheng Zhong, Ruyue Ding, Ailing Wang
The immune system may play important roles in the pathogenesis of cardiovascular disease. T-cell mediated immune responses in human progression of atherosclerotic disease and hypertension have recently been revealed, but the significance of T-cell specific chemokines in coronary artery heart disease has not been confirmed. In our study, we sought to examine the association between serum levels of the monokine induced by gamma interferon (MIG)/CXCL9 and the severity of coronary artery disease. We studied 117 patients with coronary heart disease and 80 patients with no coronary heart disease...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28100505/-5r-5-hydroxytriptolide-ameliorates-lupus-nephritis-in-mrl-lpr-mice-by-preventing-infiltration-of-immune-cells
#15
Lu-Yao Zhang, Heng Li, Yan-Wei Wu, Lei Cheng, Yu-Xi Yan, Xiao-Qian Yang, Feng-Hua Zhu, Shi-Jun He, Wei Tang, Jian-Ping Zuo
(5R)-5-Hydroxytriptolide (LLDT-8), a triptolide derivative with low toxicity, was previously reported to have strong immunosuppressive effects both in vitro and in vivo, but it remains unknown whether LLDT-8 has a therapy effect on systemic lupus erythematosus. In this study, we aimed to investigate the therapeutic effects of LLDT-8 on lupus nephritis in MRL/lpr mice, a model of systemic lupus erythematosus. Compared with vehicle group, different clinical parameters were improved upon LLDT-8 treatment: prolonged life-span of mice, decreased proteinuria, downregulated blood urea nitrogen and serum creatinine, reduced glomerular IgG deposits, and ameliorated histopathology...
January 18, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28069603/treatment-of-b-cell-disorder-improves-renal-outcome-of-patients-with-monoclonal-gammopathy-associated-c3-glomerulopathy
#16
Sophie Chauvet, Véronique Frémeaux-Bacchi, Florent Petitprez, Alexandre Karras, Laurent Daniel, Stéphane Burtey, Gabriel Choukroun, Yahsou Delmas, Dominique Guerrot, Arnaud François, Moglie Le Quintrec, Vincent Javaugue, David Ribes, Laurence Vrigneaud, Bertrand Arnulf, Jean Michel Goujon, Pierre Ronco, Guy Touchard, Frank Bridoux
The high frequency of monoclonal gammopathy in adult patients with C3 glomerulopathy (C3G) emphasizes the role of the monoclonal immunoglobulin (MIg) in the occurrence of renal disease and raises the issue of the therapeutic management. The aim of the study was to evaluate the effect of chemotherapy in a large cohort of patients with MIg-associated C3G. Fifty adult patients with MIg and biopsy-proven C3G were extracted from the French national database of C3G. We retrospectively compared renal outcomes in patients who received or not chemotherapy targeting the underlying B-cell clone...
January 9, 2017: Blood
https://www.readbyqxmd.com/read/28051834/interferon-%C3%AE-induced-protein-10-in-dengue-virus-infection
#17
REVIEW
P Fallahi, G Elia
Dengue virus (DENV) infection causes dengue fever, dengue hemorrhagic fever, or dengue shock syndrome. Interferons (IFNs), and IFN-γ dependent chemokines, chemokine (C-X-C motif) ligand (CXCL)10/IFN-γ-induced protein 10 (IP-10), CXCL9/MIG and CXCL11/I-TAC, and their common receptor chemokine (C-X-C motif) receptor (CXCR)3 are induced by DENV infection; however it has been shown that the latter two could not compensate for the absence of IP-10. This paper reviews studies about DENV and IP-10. Evidences show the importance of IP-10 induction during DENV infection, in macrophages, lymphocytes, hepatic cells, denritic cells, in skin and in the brain...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28013525/interaction-of-primary-human-trabecular-meshwork-cells-with-metal-alloy-candidates-for-micro-invasive-glaucoma-surgery
#18
Wan Wendy Wang, Kelsey A Watson, S Jeffrey Dixon, Hong Liu, Amin Rizkalla, Cindy Ml Hutnik
BACKGROUND: Microinvasive glaucoma surgery (MIGS) is a relatively new addition to the glaucoma treatment paradigm. Small metallic stents are inserted into the trabecular meshwork in order to increase aqueous humour drainage. MIGS procedures are rapidly being adopted due to a more favourable side effect profile when compared to traditional surgery. Remarkably, this rapid rate of utilization has occurred without any published studies on the effect of metal alloys used in these stents on human trabecular meshwork cells (HTMCs)...
December 25, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28011581/hippo-kinases-maintain-polarity-during-directional-cell-migration-in-caenorhabditis-elegans
#19
Guoxin Feng, Zhiwen Zhu, Wen-Jun Li, Qirong Lin, Yongping Chai, Meng-Qiu Dong, Guangshuo Ou
Precise positioning of cells is crucial for metazoan development. Despite immense progress in the elucidation of the attractive cues of cell migration, the repulsive mechanisms that prevent the formation of secondary leading edges remain less investigated. Here, we demonstrate that Caenorhabditis elegans Hippo kinases promote cell migration along the anterior-posterior body axis via the inhibition of dorsal-ventral (DV) migration. Ectopic DV polarization was also demonstrated in gain-of-function mutant animals for C...
February 1, 2017: EMBO Journal
https://www.readbyqxmd.com/read/27984415/a-cytokine-pattern-that-differentiates-pre-from-post-seroconversion-phases-of-primary-hiv-infection
#20
Lucia Pastor, Erica Parker, Jorge Carrillo, Victor Urrea, Laura Fuente-Soro, Durval Respeito, Chenjerai Jairoce, Inacio Mandomando, Julià Blanco, Denise Naniche
BACKGROUND: During acute HIV infection (AHI) HIV actively replicates but seroconversion has not yet occurred. Primary HIV infection (PHI) is characterized by a transient non-specific febrile illness, a massive inflammatory response and the progressive appearance of anti-HIV specific antibodies. In this study we have identified patterns of inflammatory biomarkers associated with the innate immunological reaction prior to completion of a full humoral response. METHODS: A symptom-based screening was used to identify AHI in the Manhiça District Hospital in Mozambique...
December 23, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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