J J Grzymski, G Elhanan, J A Morales Rosado, E Smith, K A Schlauch, R Read, C Rowan, N Slotnick, S Dabe, W J Metcalf, B Lipp, H Reed, L Sharma, E Levin, J Kao, M Rashkin, J Bowes, K Dunaway, A Slonim, N Washington, M Ferber, A Bolze, J T Lu
Three inherited autosomal dominant conditions-BRCA-related hereditary breast and ovarian cancer (HBOC), Lynch syndrome (LS) and familial hypercholesterolemia (FH)-have been termed the Centers for Disease Control and Prevention Tier 1 (CDCT1) genetic conditions, for which early identification and intervention have a meaningful potential for clinical actionability and a positive impact on public health1 . In typical medical practice, genetic testing for these conditions is based on personal or family history, ethnic background or other demographic characteristics2 ...
August 2020: Nature Medicine