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https://www.readbyqxmd.com/read/28910657/the-use-of-real-time-feedback-to-improve-kinematic-marker-placement-consistency-among-novice-examiners
#1
Charles A J Macaulay, Sean T Osis, Christian Clermont, Reed Ferber
Marker placement deviation has been shown to be the largest source of error in gait kinematic data, limiting the ability of clinicians and researchers to conduct between-day or between-center investigations. Prior marker-placement standardization methods are either impractical for a clinical setting or rely on expert marker placement. However, a recently developed, real-time feedback tool has been developed and shown to improve marker placement and downstream kinematic calculations. The purpose of this study was to determine whether this real-time marker-placement tool could improve the consistency of gait kinematic data collected by a group of novice examiners...
September 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28899433/wearable-sensors-to-predict-improvement-following-an-exercise-intervention-in-patients-with-knee-osteoarthritis
#2
Dylan Kobsar, Sean T Osis, Jeffrey E Boyd, Blayne A Hettinga, Reed Ferber
BACKGROUND: Muscle strengthening exercises consistently demonstrate improvements in the pain and function of adults with knee osteoarthritis, but individual response rates can vary greatly. Identifying individuals who are more likely to respond is important in developing more efficient rehabilitation programs for knee osteoarthritis. Therefore, the purpose of this study was to determine if pre-intervention multi-sensor accelerometer data (e.g., back, thigh, shank, foot accelerometers) and patient reported outcome measures (e...
September 12, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28833240/estimation-of-the-power-of-the-food-effect-on-qtc-to-show-assay-sensitivity
#3
Georg Ferber, Sara Fernandes, Jörg Täubel
The most recent International Conference on Harmonisation E14 Q&A document states that a separate positive control would not be necessary provided sufficiently high exposures are achieved in the early-phase studies. Realistically, a phase 1 study is unlikely to include a pharmacological positive control, and in cases in which plasma levels of the drug exceeding therapeutic levels are not achieved, the lack of a positive control can constitute a limitation when excluding an effect of regulatory concern. It has been proposed to use the effect of a standardized meal on the estimate of the diurnal time course of QTc to show assay sensitivity...
August 17, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28763575/cardiac-safety-of-rupatadine-in-a-single-ascending-dose-and-multiple-ascending-dose-study-in-healthy-japanese-subjects-using-intensive-electrocardiogram-assessments-comparison-with-the-previous-white-caucasian-thorough-qt-study
#4
J Täubel, G Ferber, S Fernandes, E Santamaría, I Izquierdo
A thorough QT/QTc study in healthy white Caucasian subjects demonstrated that rupatadine has no proarrhythmic potential and raised no cardiac safety concerns. The present phase 1 study aimed to confirm the cardiac safety of rupatadine in healthy Japanese subjects. In this randomized, double-blind, placebo-controlled study, 27 healthy Japanese subjects were administered single and multiple escalating rupatadine doses of 10, 20, and 40 mg or placebo. Triplicate electrocardiogram (ECG) recordings were performed on days -1, 1, and 5 at several points, and time-matched pharmacokinetic samples were also collected...
August 1, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28759445/estimation-of-water-quality-by-uv-vis-spectrometry-in-the-framework-of-treated-wastewater-reuse
#5
Erwan Carré, Jean Pérot, Vincent Jauzein, Liming Lin, Miguel Lopez-Ferber
The aim of this study is to investigate the potential of ultraviolet/visible (UV/Vis) spectrometry as a complementary method for routine monitoring of reclaimed water production. Robustness of the models and compliance of their sensitivity with current quality limits are investigated. The following indicators are studied: total suspended solids (TSS), turbidity, chemical oxygen demand (COD) and nitrate. Partial least squares regression (PLSR) is used to find linear correlations between absorbances and indicators of interest...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28671821/the-t-cell-receptor-can-bind-to-the-peptide-bound-major-histocompatibility-complex-and-uncomplexed-%C3%AE-2-microglobulin-through-distinct-binding-sites
#6
Patrick S Merkle, Melita Irving, Song Hongjian, Mathias Ferber, Thomas J D Jørgensen, Kirsten Scholten, Immanuel Luescher, George Coukos, Vincent Zoete, Michel A Cuendet, Olivier Michielin, Kasper D Rand
T-Cell receptor (TCR)-mediated recognition of the peptide-bound major histocompatibility complex (pMHC) initiates an adaptive immune response against antigen-presenting target cells. The recognition events take place at the TCR-pMHC interface, and their effects on TCR conformation and dynamics are controversial. Here, we have measured the time-resolved hydrogen/deuterium exchange (HDX) of a soluble TCR in the presence and absence of its cognate pMHC by mass spectrometry to delineate the impact of pMHC binding on solution-phase structural dynamics in the TCR...
August 1, 2017: Biochemistry
https://www.readbyqxmd.com/read/28647484/neural-representation-of-geometry-and-surface-properties-in-object-and-scene-perception
#7
Matthew X Lowe, Jason Rajsic, Jason P Gallivan, Susanne Ferber, Jonathan S Cant
Multiple cortical regions are crucial for perceiving the visual world, yet the processes shaping representations in these regions are unclear. To address this issue, we must elucidate how perceptual features shape representations of the environment. Here, we explore how the weighting of different visual features affects neural representations of objects and scenes, focusing on the scene-selective parahippocampal place area (PPA), but additionally including the retrosplenial complex (RSC), occipital place area (OPA), lateral occipital (LO) area, fusiform face area (FFA) and occipital face area (OFA)...
June 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/28617903/association-between-patient-review-of-systems-score-and-somatization
#8
Tyler Stephen Okland, Joseph Robert Gonzalez, Alexander Thomas Ferber, Scott Edward Mann
Importance: Somatization is a condition in which psychological distress is manifested by medically unexplained symptoms, and it is prevalent in all medical specialties, including otolaryngology. Recognition of somatization can be difficult, and there are limited methods available. Objectives: To determine whether patients with somatization respond differently to the review of systems (ROS) portion of the patient interview and whether the ROS can be used to identify patients with somatization...
June 15, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28612353/lca-case-study-tertiary-treatment-process-options-for-wastewater-reuse
#9
Erwan Carré, Joana Beigbeder, Vincent Jauzein, Guillaume Junqua, Miguel Lopez-Ferber
Tertiary treatment process (including filtration and/or disinfection) is necessary to obtain a water quality suited for high-quality reuse from wastewater treatment. Industrial pilots representing small real size treatment units were set up downstream of a conventional secondary treatment of a wastewater treatment plant in the South of France and their performance followed for two years. Life-cycle assessment (LCA) methodology is used to compare the environmental impacts of different treatment processes. Five tertiary treatment trains were studied: 1) sand filtration + storage followed by ultraviolet (UV) dynamic reactor disinfection (SF-UVD), 2) sand filtration (SF) + UV batch reactor disinfection (SF-UVB), 3) ultrafiltration (UF), 4) ultrafiltration and UV batch reactor disinfection (UF-UVB), 5) microfiltration (MF) and storage followed by dynamic UV disinfection (MF-UVD)...
June 13, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28598663/measurement-of-the-%C3%AF-lepton-polarization-and-r-d-in-the-decay-b-over-%C3%A2-%C3%A2-d-%C3%AF-%C3%AE-over-%C3%A2-_-%C3%AF
#10
S Hirose, T Iijima, I Adachi, K Adamczyk, H Aihara, S Al Said, D M Asner, H Atmacan, V Aulchenko, T Aushev, R Ayad, V Babu, I Badhrees, A M Bakich, V Bansal, E Barberio, P Behera, M Berger, B Bhuyan, J Biswal, A Bondar, G Bonvicini, A Bozek, M Bračko, T E Browder, D Červenkov, P Chang, A Chen, B G Cheon, K Chilikin, R Chistov, K Cho, Y Choi, D Cinabro, M Danilov, N Dash, S Di Carlo, J Dingfelder, Z Doležal, Z Drásal, D Dutta, S Eidelman, D Epifanov, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, P Goldenzweig, B Golob, D Greenwald, J Grygier, J Haba, K Hara, J Hasenbusch, K Hayasaka, H Hayashii, T Higuchi, W-S Hou, C-L Hsu, K Inami, G Inguglia, A Ishikawa, R Itoh, Y Iwasaki, W W Jacobs, I Jaegle, Y Jin, D Joffe, K K Joo, T Julius, Y Kato, T Kawasaki, H Kichimi, C Kiesling, D Y Kim, J B Kim, K T Kim, M J Kim, S H Kim, K Kinoshita, P Kodyš, S Korpar, D Kotchetkov, P Križan, P Krokovny, T Kuhr, R Kulasiri, R Kumar, Y-J Kwon, J S Lange, C H Li, L Li, Y Li, L Li Gioi, J Libby, D Liventsev, M Lubej, T Luo, J MacNaughton, M Masuda, T Matsuda, D Matvienko, K Miyabayashi, H Miyake, H Miyata, R Mizuk, G B Mohanty, H K Moon, T Mori, R Mussa, M Nakao, T Nanut, K J Nath, Z Natkaniec, M Nayak, M Niiyama, N K Nisar, S Nishida, S Ogawa, S Okuno, H Ono, Y Onuki, W Ostrowicz, P Pakhlov, G Pakhlova, B Pal, C W Park, H Park, S Paul, L Pesántez, R Pestotnik, L E Piilonen, K Prasanth, M Ritter, A Rostomyan, M Rozanska, Y Sakai, S Sandilya, L Santelj, T Sanuki, Y Sato, V Savinov, T Schlüter, O Schneider, G Schnell, C Schwanda, Y Seino, K Senyo, O Seon, M E Sevior, V Shebalin, C P Shen, T-A Shibata, J-G Shiu, F Simon, A Sokolov, E Solovieva, M Starič, J F Strube, K Sumisawa, T Sumiyoshi, M Takizawa, U Tamponi, F Tenchini, K Trabelsi, M Uchida, T Uglov, Y Unno, S Uno, P Urquijo, Y Ushiroda, Y Usov, C Van Hulse, G Varner, K E Varvell, A Vossen, C H Wang, M-Z Wang, P Wang, M Watanabe, Y Watanabe, E Widmann, E Won, Y Yamashita, H Ye, J Yelton, C Z Yuan, Z P Zhang, V Zhilich, V Zhulanov, A Zupanc
We report the first measurement of the τ lepton polarization P_{τ}(D^{*}) in the decay B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ} as well as a new measurement of the ratio of the branching fractions R(D^{*})=B(B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]→D^{*}ℓ^{-}ν[over ¯]_{ℓ}), where ℓ^{-} denotes an electron or a muon, and the τ is reconstructed in the modes τ^{-}→π^{-}ν_{τ} and τ^{-}→ρ^{-}ν_{τ}. We use the full data sample of 772×10^{6}  BB[over ¯] pairs recorded with the Belle detector at the KEKB electron-positron collider...
May 26, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28540453/linking-anxiety-and-insistence-on-sameness-in-autistic-children-the-role-of-sensory-hypersensitivity
#11
Karen R Black, Ryan A Stevenson, Magali Segers, Busiswe L Ncube, Sol Z Sun, Aviva Philipp-Muller, James M Bebko, Morgan D Barense, Susanne Ferber
Sensory hypersensitivity and insistence on sameness (I/S) are common, co-occurring features of autism, yet the relationship between them is poorly understood. This study assessed the impact of sensory hypersensitivity on the clinical symptoms of specific phobia, separation anxiety, social anxiety and I/S for autistic and typically developing (TD) children. Parents of 79 children completed questionnaires on their child's difficulties related to sensory processing, I/S, and anxiety. Results demonstrated that sensory hypersensitivity mediated 67% of the relationship between symptoms of specific phobia and I/S and 57% of the relationship between separation anxiety and I/S...
August 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28506185/the-cascading-influence-of-multisensory-processing-on-speech-perception-in-autism
#12
Ryan A Stevenson, Magali Segers, Busisiwe L Ncube, Karen R Black, James M Bebko, Susanne Ferber, Morgan D Barense
It has been recently theorized that atypical sensory processing in autism relates to difficulties in social communication. Through a series of tasks concurrently assessing multisensory temporal processes, multisensory integration and speech perception in 76 children with and without autism, we provide the first behavioral evidence of such a link. Temporal processing abilities in children with autism contributed to impairments in speech perception. This relationship was significantly mediated by their abilities to integrate social information across auditory and visual modalities...
May 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28487885/novel-de-novo-variant-in-ebf3-is-likely-to-impact-dna-binding-in-a-patient-with-a-neurodevelopmental-disorder-and-expanded-phenotypes-patient-report-in-silico-functional-assessment-and-review-of-published-cases
#13
Patrick R Blackburn, Sarah S Barnett, Michael T Zimmermann, Margot A Cousin, Charu Kaiwar, Filippo Pinto E Vairo, Zhiyv Niu, Matthew J Ferber, Raul A Urrutia, Duygu Selcen, Eric W Klee, Pavel N Pichurin
Pathogenic variants in EBF3 were recently described in three back-to-back publications in association with a novel neurodevelopmental disorder characterized by intellectual disability, speech delay, ataxia, and facial dysmorphisms. In this report, we describe an additional patient carrying a de novo missense variant in EBF3 (c.487C>T, p.(Arg163Trp)) that falls within a conserved residue in the zinc knuckle motif of the DNA binding domain. Without a solved structure of the DNA binding domain, we generated a homology-based atomic model and performed molecular dynamics simulations for EBF3, which predicted decreased DNA affinity for p...
May 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28467759/nucleated-red-blood-cells-as-a-marker-of-acute-and-chronic-fetal-hypoxia-in-a-rat-model
#14
Victoria K Minior, Brian Levine, Asaf Ferber, Seth Guller, Michael Y Divon
OBJECTIVE: To examine the relationship between duration of fetal hypoxia, nucleated red blood cell (NRBC) count, and fetal growth. METHODS: Pregnant rats were exposed to a severe hypoxia (9.5%-10% O2) for varying time intervals (2, 6, 12, 24, 48, and 120 hours; n=4 for each time interval) immediately prior to delivery at term. Normoxic controls were exposed to room air (21% O2) and matched for all other study variables (n=4 rats for each time interval). Pups were delivered via hysterotomy while maintaining exposure gas concentrations...
April 28, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/28368653/lepton-flavor-dependent-angular-analysis-of-b%C3%A2-k-%C3%A2-%C3%A2
#15
S Wehle, C Niebuhr, S Yashchenko, I Adachi, H Aihara, S Al Said, D M Asner, V Aulchenko, T Aushev, R Ayad, T Aziz, V Babu, A M Bakich, V Bansal, E Barberio, W Bartel, P Behera, B Bhuyan, J Biswal, A Bobrov, A Bondar, G Bonvicini, A Bozek, M Bračko, T E Browder, D Červenkov, P Chang, V Chekelian, A Chen, B G Cheon, K Chilikin, R Chistov, K Cho, Y Choi, D Cinabro, N Dash, J Dingfelder, Z Doležal, Z Drásal, D Dutta, S Eidelman, D Epifanov, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, R Gillard, P Goldenzweig, B Golob, O Grzymkowska, E Guido, J Haba, T Hara, K Hayasaka, H Hayashii, M T Hedges, W-S Hou, C-L Hsu, T Iijima, K Inami, G Inguglia, A Ishikawa, R Itoh, Y Iwasaki, W W Jacobs, I Jaegle, H B Jeon, Y Jin, D Joffe, K K Joo, T Julius, A B Kaliyar, K H Kang, G Karyan, P Katrenko, T Kawasaki, H Kichimi, C Kiesling, D Y Kim, H J Kim, J B Kim, K T Kim, M J Kim, S H Kim, K Kinoshita, L Koch, P Kodyš, S Korpar, D Kotchetkov, P Križan, P Krokovny, T Kuhr, R Kulasiri, T Kumita, A Kuzmin, Y-J Kwon, J S Lange, C H Li, L Li, Y Li, L Li Gioi, J Libby, D Liventsev, M Lubej, T Luo, M Masuda, T Matsuda, K Miyabayashi, H Miyake, R Mizuk, G B Mohanty, T Mori, R Mussa, E Nakano, M Nakao, T Nanut, K J Nath, Z Natkaniec, M Nayak, N K Nisar, S Nishida, S Ogawa, H Ono, Y Onuki, G Pakhlova, B Pal, C-S Park, C W Park, H Park, S Paul, L Pesántez, L E Piilonen, C Pulvermacher, J Rauch, M Ritter, A Rostomyan, Y Sakai, S Sandilya, L Santelj, T Sanuki, Y Sato, V Savinov, T Schlüter, O Schneider, G Schnell, C Schwanda, A J Schwartz, Y Seino, K Senyo, O Seon, I S Seong, M E Sevior, C P Shen, T-A Shibata, J-G Shiu, B Shwartz, F Simon, R Sinha, E Solovieva, M Starič, J F Strube, K Sumisawa, T Sumiyoshi, M Takizawa, U Tamponi, F Tenchini, K Trabelsi, T Tsuboyama, M Uchida, T Uglov, Y Unno, S Uno, P Urquijo, Y Ushiroda, Y Usov, S E Vahsen, C Van Hulse, G Varner, K E Varvell, V Vorobyev, A Vossen, E Waheed, C H Wang, M-Z Wang, P Wang, M Watanabe, Y Watanabe, E Widmann, K M Williams, E Won, H Yamamoto, Y Yamashita, H Ye, Y Yook, C Z Yuan, Y Yusa, Z P Zhang, V Zhilich, V Zhukova, V Zhulanov, M Ziegler, A Zupanc
We present a measurement of angular observables and a test of lepton flavor universality in the B→K^{*}ℓ^{+}ℓ^{-} decay, where ℓ is either e or μ. The analysis is performed on a data sample corresponding to an integrated luminosity of 711  fb^{-1} containing 772×10^{6} BB[over ¯] pairs, collected at the ϒ(4S) resonance with the Belle detector at the asymmetric-energy e^{+}e^{-} collider KEKB. The result is consistent with standard model (SM) expectations, where the largest discrepancy from a SM prediction is observed in the muon modes with a local significance of 2...
March 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28339177/multisensory-speech-perception-in-autism-spectrum-disorder-from-phoneme-to-whole-word-perception
#16
Ryan A Stevenson, Sarah H Baum, Magali Segers, Susanne Ferber, Morgan D Barense, Mark T Wallace
Speech perception in noisy environments is boosted when a listener can see the speaker's mouth and integrate the auditory and visual speech information. Autistic children have a diminished capacity to integrate sensory information across modalities, which contributes to core symptoms of autism, such as impairments in social communication. We investigated the abilities of autistic and typically-developing (TD) children to integrate auditory and visual speech stimuli in various signal-to-noise ratios (SNR). Measurements of both whole-word and phoneme recognition were recorded...
July 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28317127/two-pathways-to-self-forgiveness-a-hedonic-path-via-self-compassion-and-a-eudaimonic-path-via-the-reaffirmation-of-violated-values
#17
Lydia Woodyatt, Michael Wenzel, Matthew Ferber
Self-forgiveness is often measured as a hedonic end-state, as the presence of positive affect and the absence of negative affect towards the self following a wrongdoing. However, self-forgiveness is also referred to as a difficult process. Self-forgiveness as a process of accepting responsibility and working through one's wrongdoing is a substantially un-hedonic - it is likely to be uncomfortable and at times painful. In this study, we examine two pathways to self-forgiveness: a hedonic focused pathway (via self-compassion) and a eudaimonic pathway (via reaffirmation of transgressed values)...
March 20, 2017: British Journal of Social Psychology
https://www.readbyqxmd.com/read/28303754/effects-of-running-experience-on-coordination-and-its-variability-in-runners
#18
Pablo Floría, Alberto Sánchez-Sixto, Reed Ferber, Andrew J Harrison
The purpose of this study was to examine the differences in coordination variability in running gait between trained runners and non-runners using continuous relative phase (CRP) analysis. Lower extremity kinematic data were collected for 22 participants during the stance phase. The participants were assigned to either a runner or non-runner group based on running volume training. Segment coordination and coordination variability were calculated for selected hip-knee and knee-ankle couplings. Independent t-tests and magnitude-based inferences were used to compare the 2 groups...
March 17, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28277107/gender-age-and-time-dependent-dosing-of-growth-hormone-in-adults-real-world-data-from-a-decade-of-clinical-practice-in-germany
#19
Peter H Kann, Simona Bergmann, Günter K Stalla, Christina Dimopoulou, Matthias M Weber, Birgitte T Pedersen, Stefanie Meckes-Ferber
We evaluated treatment patterns and gender-dependent dosing of growth hormone (GH) substitution in adults with GH deficiency (AGHD). Data on GH dose were collected (2003-2013) from 509 GH-treated patients (mean age: 48.9 years; 47% female) enroled in the observational German NordiWin study (NCT01543880). The impact of gender, age, treatment duration and calendar year on GH treatment patterns was evaluated by multiple regression analysis. Mean (SD) baseline GH dose (mg/day) was similar between females (0...
March 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28253053/kinematic-gait-patterns-in-competitive-and-recreational-runners
#20
Christian A Clermont, Sean T Osis, Angkoon Phinyomark, Reed Ferber
Certain homogeneous running subgroups demonstrate distinct kinematic patterns in running; however, the running mechanics of competitive and recreational runners are not well understood. Therefore, the purpose of this study was to determine whether we could separate and classify competitive and recreational runners according to gait kinematics using multivariate analyses and a machine learning approach. Participants were allocated to the 'competitive' (n = 20) or 'recreational' group (n = 15) based on age, sex, and recent race performance...
September 5, 2017: Journal of Applied Biomechanics
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