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Ostap Kalyuzhnyi, Jaroslav Ilnytskyi, Yurij Holovatch, Christian Von Ferber
In this paper we study the shape characteristics of star-like polymer in various solvent quality using a mesoscopic level of modeling. The dissipative particle dynamics simulations are performed for the homogeneous and four different heterogeneous star polymers with the same molecular weight. We analyse the gyration radius and asphericity at the bad, good and Θ-solvent regimes. Detailed explanation based on interplay between enthalpic and entropic contributions to the free energy and analyses on of the asphericity of individual branches are provided to explain the increase of the apsphericity in Θ-solvent regime...
April 6, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
#2
Boaz Mendzelevski, Georg Ferber, Filip Janku, Bob T Li, Ryan J Sullivan, Dean Welsch, Wei Chi, Jeanne Jackson, Onglee Weng, Philip T Sager
PURPOSE: The aim of this analysis was to investigate the potential for ulixertinib (BVD-523) to prolong cardiac repolarization. The mean prolongation of the corrected QT (QTc) interval was predicted at the mean maximum drug concentrations of the recommended phase 2 dose (RP2D; 600 mg BID) and of higher concentrations. In addition, the effect of ulixertinib on other quantitative ECG parameters was assessed. METHODS: In a two-part, phase 1, open-label study in adults with advanced solid tumors, 105 patients [24 in Part 1 (dose escalation) and 81 in Part 2 (cohort expansion)] were included in a QT prolongation analysis...
March 30, 2018: Cancer Chemotherapy and Pharmacology
#3
Mamatha Siricilla, Lydia Irwin, Andres Ferber
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a subtype of nonclassical Hodgkin lymphoma (HL). It resembles non-Hodgkin lymphoma (NHL), by expressing classic B cell markers such as CD20 and CD79a however lacks definitive HL markers (such as CD15 and CD30). T cell histiocyte-rich large B cell lymphoma (THRLBCL), on the other hand, is a distinct entity classified under NHL and considered a variant of diffuse large B cell lymphoma (DLBCL). NLPHL can look morphologically and immunologically similar to THRLBCL and often poses a diagnostic challenge...
2018: Case Reports in Oncological Medicine
#4
Maarten Timmers, Vikash Sinha, Borje Darpo, Brian Smith, Randy Brown, Hongqi Xue, Georg Ferber, Johannes Streffer, Alberto Russu, Luc Tritsmans, Bhavna Solanki, Jennifer Bogert, Luc Van Nueten, Giacomo Salvadore, Partha Nandy
Nonclinical assays with JNJ-54861911, a β-secretase 1 inhibitor have indicated that at high concentrations, it may delay cardiac repolarization. A 4-way crossover thorough QT (TQT) study was performed in 64 healthy subjects with 50 and 150 mg JNJ-54861911 once daily for 7 days, placebo, and 400 mg moxifloxacin. Retrospective high-precision QT (HPQT) analysis was performed on serial elecrocardiograms extracted from first-in-human single-ascending dose (SAD) and multiple-ascending dose (MAD) studies to evaluate if early studies could detect and predict QT effect...
March 5, 2018: Journal of Clinical Pharmacology
#5
Jörg Täubel, Ulrike Lorch, Simon Coates, Sara Fernandes, Paul Foley, Georg Ferber, Jean-Pierre Gotteland, Oliver Pohl
OBE022, a new orally active prostaglandin F2α receptor antagonist (OBE022) with myometrial selectivity is being developed to reduce uterine contractions during preterm labor. This first-in-human study evaluated the effect of OBE022 following multiple doses on the QT interval in 23 healthy postmenopausal women, using the effect of a meal on QTc to demonstrate assay sensitivity. We report the cardiac safety outcome performed during the multiple ascending part of this trial. OBE022 was administered after a standardized breakfast on day 1 and in the fasted state from day 3 to day 9 wth a standardized lunch 4 hours after administration...
February 28, 2018: Clinical Pharmacology in Drug Development
#6
Lauren C Benson, Christian A Clermont, Sean T Osis, Dylan Kobsar, Reed Ferber
Accelerometers have been used to classify running patterns, but classification accuracy and computational load depends on signal segmentation and feature extraction. Stride-based segmentation relies on identifying gait events, a step avoided by using window-based segmentation. For each segment, discrete points can be extracted from the accelerometer signal, or advanced features can be computed. Therefore, the purpose of this study was to examine how different segmentation and feature extraction methods influence the accuracy and computational load of classifying running conditions...
February 8, 2018: Journal of Biomechanics
#7
Peter H Kann, Simona Bergmann, Martin Bidlingmaier, Christina Dimopoulou, Birgitte T Pedersen, Günter K Stalla, Matthias M Weber, Stefanie Meckes-Ferber
BACKGROUND: The adverse effects of growth hormone (GH) deficiency (GHD) in adults (AGHD) on metabolism and health-related quality of life (HRQoL) can be improved with GH substitution. This investigation aimed to design a score summarising the features of GHD and evaluate its ability to measure the effect of GH substitution in AGHD. METHODS: The Growth hormone deficiency and Efficacy of Treatment (GET) score (0-100 points) assessed (weighting): HRQoL (40%), disease-related days off work (10%), bone mineral density (20%), waist circumference (10%), low-density lipoprotein cholesterol (10%) and body fat mass (10%)...
February 13, 2018: BMC Endocrine Disorders
#8
Georg Ferber, Yaning Sun, Borje Darpo, Christine Garnett, Jiang Liu
The operating characteristics of dose-escalating studies in terms of false-negative predictions of the QT effect and the power to exclude clinically relevant QT effects are not quantitatively established. One thousand single-ascending-dose (SAD) studies with 7 dose groups with 6/2 subjects on active drug/placebo were generated through simulation for each of 32 scenarios with (1) 8 different QT effects of the study drug and (2) achieved plasma concentration 2- or 4-fold above therapeutic levels. For each subject, drug-free QT data from a thorough QT study were subsampled to capture the circadian profile, on which a drug effect was added...
February 8, 2018: Journal of Clinical Pharmacology
#9
Helit Cohen, Hila Barash, Irit Meivar-Levy, Kfir Molakandov, Marina Ben-Shimon, Michael Gurevich, Fatima Zoabi, Adi Har-Zahav, Rolf Gebhardt, Frank Gaunitz, Michael Gurevich, Eytan Mor, Philippe Ravassard, Shoshana Greenberger, Sarah Ferber
Transdifferentiation (TD) is the direct reprogramming of adult cells into cells of alternate fate and function. We were the first to show that liver cells can be transdifferentiated into beta-like, insulin producing cells, by ectopic expression of pancreatic transcription factors (pTFs). However, the efficiency of the process was consistently limited to <15% of the human liver cells treated in culture. The data in the current study suggest that liver to pancreas TD is restricted to a specific population of liver cells that is predisposed to undergo reprogramming...
February 2, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#10
Jessica C Tomazic, Joy O Ogunmuyiwa, Gretchen A Ferber
By examining mental illness through the lens of intimate firsthand accounts of caregivers and patients, including caregiver blogposts and a conversation between Liza Long and her son as recorded by StoryCorps, we demonstrate how new media can be leveraged to shift societal perceptions of those with mental illness from blameworthy potential perpetrators of terror to vulnerable persons in need of compassion and support. Exploring patient, caregiver, and societal roles through a close reading of new media firsthand accounts, we argue for shared responsibility in caring for those with mental illness and, in particular, for physicians to leverage their unique knowledge of the patient experience by promoting media coverage of stories of mental illness recovery...
January 1, 2018: AMA Journal of Ethics
#11
AmirAli Jafarnezhadgero, Morteza Madadi Shad, Reed Ferber
INTRODUCTION: It has been widely postulated that structural and functional misalignments of the foot, such as flat foot, may cause mechanical deviations of the lower limb during walking. The aim of this study was to investigate the effect of foot orthoses on lower extremity joint moment asymmetry during the stance phase of walking in children with asymptomatic flexible flat feet. METHODS: Fourteen volunteer male children, clinically diagnosed with flexible flat feet, participated in this study...
January 2018: Journal of Bodywork and Movement Therapies
#12
Christine Garnett, Peter L Bonate, Qianyu Dang, Georg Ferber, Dalong Huang, Jiang Liu, Devan Mehrotra, Steve Riley, Philip Sager, Christoffer Tornoe, Yaning Wang
The original version of this article unfortunately contained an error in Equation 1 under the section "Pre-specified linear mixed effects model". The correct equation has given below.
January 12, 2018: Journal of Pharmacokinetics and Pharmacodynamics
#13
REVIEW
Megan A Allyse, David H Robinson, Matthew J Ferber, Richard R Sharp
Direct-to-consumer (DTC) genetic testing emerged in the early 2000s as a means of allowing consumers to access information on their genetics without the involvement of a physician. Although early models of DTC were popular with consumers, they were controversial in medical and regulatory circles. In this article, we trace the history of DTC genetic testing, discuss its regulatory implications, and describe the emergence of a new hybrid model we call DTC 2.0.
January 2018: Mayo Clinic Proceedings
#14
W Frank Peacock, Timothy E Van Meter, Nazanin Mirshahi, Kyle Ferber, Robert Gerwien, Vani Rao, Haris Iqbal Sair, Ramon Diaz-Arrastia, Frederick K Korley
Background: Nearly 5 million emergency department (ED) visits for head injury occur each year in the United States, of which <10% of patients show abnormal computed tomography (CT) findings. CT negative patients frequently suffer protracted somatic, behavioral, and neurocognitive dysfunction. Our goal was to evaluate biomarkers to identify mild TBI (mTBI) in patients with suspected head injury. Methods: An observational ED study of head-injured and control patients was conducted at Johns Hopkins University (HeadSMART)...
2017: Frontiers in Neurology
#15
De-Kun Li, Hong Chen, Jeannette R Ferber, Roxana Odouli, Charles Quesenberry
Magnetic field (MF) non-ionizing radiation is widespread and everyone is exposed to some degree. This prospective cohort study of 913 pregnant women examined the association between high MF exposure and miscarriage risk. Cox (proportional hazards) regression was used to examine the association. After controlling for multiple other factors, women who were exposed to higher MF levels had 2.72 times the risk of miscarriage (hazard ratio = 2.72, 95% CI: 1.42-5.19) than those with lower MF exposure. The increased risk of miscarriage associated with high MF was consistently observed regardless of the sources of high MF...
December 13, 2017: Scientific Reports
#16
T Horiguchi, A Ishikawa, H Yamamoto, I Adachi, H Aihara, S Al Said, D M Asner, V Aulchenko, T Aushev, R Ayad, V Babu, I Badhrees, A M Bakich, V Bansal, P Behera, V Bhardwaj, B Bhuyan, J Biswal, A Bobrov, G Bonvicini, A Bozek, M Bračko, T E Browder, D Červenkov, V Chekelian, A Chen, B G Cheon, K Chilikin, K Cho, Y Choi, D Cinabro, T Czank, N Dash, S Di Carlo, Z Doležal, Z Drásal, D Dutta, S Eidelman, D Epifanov, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, M Gelb, R Gillard, P Goldenzweig, B Golob, Y Guan, E Guido, J Haba, T Hara, K Hayasaka, H Hayashii, M T Hedges, T Higuchi, S Hirose, W-S Hou, T Iijima, K Inami, G Inguglia, R Itoh, Y Iwasaki, W W Jacobs, I Jaegle, H B Jeon, S Jia, Y Jin, D Joffe, K K Joo, T Julius, K H Kang, T Kawasaki, D Y Kim, J B Kim, K T Kim, M J Kim, S H Kim, Y J Kim, K Kinoshita, P Kodyš, S Korpar, D Kotchetkov, P Križan, P Krokovny, T Kuhr, R Kulasiri, R Kumar, T Kumita, A Kuzmin, Y-J Kwon, J S Lange, C H Li, L Li, L Li Gioi, J Libby, D Liventsev, M Lubej, T Luo, M Masuda, T Matsuda, D Matvienko, M Merola, K Miyabayashi, H Miyata, R Mizuk, G B Mohanty, S Mohanty, H K Moon, T Mori, R Mussa, E Nakano, M Nakao, T Nanut, K J Nath, Z Natkaniec, M Nayak, N K Nisar, S Nishida, S Ogawa, S Okuno, H Ono, P Pakhlov, G Pakhlova, B Pal, S Pardi, C-S Park, H Park, S Paul, T K Pedlar, R Pestotnik, L E Piilonen, K Prasanth, C Pulvermacher, J Rauch, A Rostomyan, Y Sakai, S Sandilya, L Santelj, V Savinov, O Schneider, G Schnell, C Schwanda, A J Schwartz, Y Seino, K Senyo, I S Seong, M E Sevior, V Shebalin, C P Shen, T-A Shibata, J-G Shiu, F Simon, A Sokolov, E Solovieva, M Starič, J F Strube, K Sumisawa, T Sumiyoshi, M Takizawa, U Tamponi, K Tanida, F Tenchini, K Trabelsi, M Uchida, T Uglov, Y Unno, S Uno, P Urquijo, Y Ushiroda, Y Usov, C Van Hulse, G Varner, A Vinokurova, V Vorobyev, A Vossen, C H Wang, M-Z Wang, P Wang, Y Watanabe, S Watanuki, T Weber, E Widmann, E Won, Y Yamashita, H Ye, Z P Zhang, V Zhilich, V Zhukova, V Zhulanov, A Zupanc
We report the first evidence for isospin violation in B→K^{*}γ and the first measurement of the difference of CP asymmetries between B^{+}→K^{*+}γ and B^{0}→K^{*0}γ. This analysis is based on the data sample containing 772×10^{6}BB[over ¯] pairs that was collected with the Belle detector at the KEKB energy-asymmetric e^{+}e^{-} collider. We find evidence for the isospin violation with a significance of 3.1σ, Δ_{0+}=[+6.2±1.5(stat)±0.6(syst)±1.2(f_{+-}/f_{00})]%, where the third uncertainty is due to the uncertainty on the fraction of B^{+}B^{-} to B^{0}B[over ¯]^{0} production in ϒ(4S) decays...
November 10, 2017: Physical Review Letters
#17
N Dash, S Bahinipati, V Bhardwaj, K Trabelsi, I Adachi, H Aihara, S Al Said, D M Asner, V Aulchenko, T Aushev, R Ayad, V Babu, I Badhrees, A M Bakich, V Bansal, E Barberio, B Bhuyan, J Biswal, A Bobrov, A Bondar, G Bonvicini, A Bozek, M Bračko, F Breibeck, T E Browder, D Červenkov, M-C Chang, V Chekelian, A Chen, B G Cheon, K Chilikin, K Cho, Y Choi, D Cinabro, S Di Carlo, Z Doležal, Z Drásal, D Dutta, S Eidelman, D Epifanov, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, R Gillard, P Goldenzweig, J Haba, T Hara, K Hayasaka, H Hayashii, M T Hedges, W-S Hou, T Iijima, K Inami, A Ishikawa, R Itoh, Y Iwasaki, W W Jacobs, I Jaegle, H B Jeon, Y Jin, D Joffe, K K Joo, T Julius, J Kahn, A B Kaliyar, G Karyan, P Katrenko, T Kawasaki, C Kiesling, D Y Kim, H J Kim, J B Kim, K T Kim, M J Kim, S H Kim, Y J Kim, K Kinoshita, P Kodyš, S Korpar, D Kotchetkov, P Križan, P Krokovny, T Kuhr, R Kulasiri, R Kumar, T Kumita, A Kuzmin, Y-J Kwon, J S Lange, I S Lee, C H Li, L Li, Y Li, L Li Gioi, J Libby, D Liventsev, M Lubej, T Luo, M Masuda, D Matvienko, M Merola, K Miyabayashi, H Miyata, R Mizuk, G B Mohanty, S Mohanty, H K Moon, T Mori, R Mussa, E Nakano, M Nakao, T Nanut, K J Nath, Z Natkaniec, M Nayak, M Niiyama, N K Nisar, S Nishida, S Ogawa, S Okuno, H Ono, P Pakhlov, G Pakhlova, B Pal, S Pardi, C-S Park, H Park, S Paul, T K Pedlar, L Pesántez, R Pestotnik, L E Piilonen, K Prasanth, M Ritter, A Rostomyan, H Sahoo, Y Sakai, S Sandilya, L Santelj, T Sanuki, Y Sato, V Savinov, O Schneider, G Schnell, C Schwanda, A J Schwartz, Y Seino, K Senyo, M E Sevior, V Shebalin, C P Shen, T-A Shibata, J-G Shiu, B Shwartz, F Simon, A Sokolov, E Solovieva, M Starič, J F Strube, J Stypula, K Sumisawa, T Sumiyoshi, M Takizawa, U Tamponi, K Tanida, F Tenchini, M Uchida, T Uglov, Y Unno, S Uno, P Urquijo, Y Usov, C Van Hulse, G Varner, V Vorobyev, A Vossen, E Waheed, C H Wang, M-Z Wang, P Wang, M Watanabe, Y Watanabe, E Widmann, K M Williams, E Won, Y Yamashita, H Ye, J Yelton, Y Yook, C Z Yuan, Y Yusa, Z P Zhang, V Zhilich, V Zhukova, V Zhulanov, A Zupanc
We report a study of the decay D^{0}→K_{S}^{0}K_{S}^{0} using 921 fb^{-1} of data collected at or near the ϒ(4S) and ϒ(5S) resonances with the Belle detector at the KEKB asymmetric energy e^{+}e^{-} collider. The measured time-integrated CP asymmetry is A_{CP}(D^{0}→K_{S}^{0}K_{S}^{0})=(-0.02±1.53±0.02±0.17)%, and the branching fraction is B(D^{0}→K_{S}^{0}K_{S}^{0})=(1.321±0.023±0.036±0.044)×10^{-4}, where the first uncertainty is statistical, the second is systematic, and the third is due to the normalization mode (D^{0}→K_{S}^{0}π^{0})...
October 27, 2017: Physical Review Letters
#18
REVIEW
Christine Garnett, Peter L Bonate, Qianyu Dang, Georg Ferber, Dalong Huang, Jiang Liu, Devan Mehrotra, Steve Riley, Philip Sager, Christoffer Tornoe, Yaning Wang
The International Council for Harmonisation revised the E14 guideline through the questions and answers process to allow concentration-QTc (C-QTc) modeling to be used as the primary analysis for assessing the QTc interval prolongation risk of new drugs. A well-designed and conducted QTc assessment based on C-QTc modeling in early phase 1 studies can be an alternative approach to a thorough QT study for some drugs to reliably exclude clinically relevant QTc effects. This white paper provides recommendations on how to plan and conduct a definitive QTc assessment of a drug using C-QTc modeling in early phase clinical pharmacology and thorough QT studies...
December 5, 2017: Journal of Pharmacokinetics and Pharmacodynamics
#19
Aaron Fox, Reed Ferber, Natalie Saunders, Sean Osis, Jason Bonacci
PURPOSE: This study aimed to identify the discriminating kinematic gait characteristics between individuals with acute and chronic patellofemoral pain (PFP) and healthy controls. METHODS: Ninety-eight runners with PFP (39 male, 59 female) and 98 healthy control runners (38 male, 60 female) ran on a treadmill at a self-selected speed while three-dimensional lower limb kinematic data were collected. Runners with PFP were split into acute (n = 25) and chronic (n = 73) subgroups on the basis of whether they had been experiencing pain for less or greater than 3 months, respectively...
March 2018: Medicine and Science in Sports and Exercise
#20
Shiran Ferber, Galia Tiram, Ana Sousa-Herves, Anat Eldar-Boock, Adva Krivitsky, Anna Scomparin, Eilam Yeini, Paula Ofek, Dikla Ben-Shushan, Laura Isabel Vossen, Kai Licha, Rachel Grossman, Zvi Ram, Jack Henkin, Eytan Ruppin, Noam Auslander, Rainer Haag, Marcelo Calderón, Ronit Satchi-Fainaro
Glioblastoma is a highly aggressive brain tumor. Current standard-of-care results in a marginal therapeutic outcome, partly due to acquirement of resistance and insufficient blood-brain barrier (BBB) penetration of chemotherapeutics. To circumvent these limitations, we conjugated the chemotherapy paclitaxel (PTX) to a dendritic polyglycerol sulfate (dPGS) nanocarrier. dPGS is able to cross the BBB, bind to P/L-selectins and accumulate selectively in intracranial tumors. We show that dPGS has dual targeting properties, as we found that P-selectin is not only expressed on tumor endothelium but also on glioblastoma cells...
October 4, 2017: ELife
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