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https://www.readbyqxmd.com/read/28540453/linking-anxiety-and-insistence-on-sameness-in-autistic-children-the-role-of-sensory-hypersensitivity
#1
Karen R Black, Ryan A Stevenson, Magali Segers, Busiswe L Ncube, Sol Z Sun, Aviva Philipp-Muller, James M Bebko, Morgan D Barense, Susanne Ferber
Sensory hypersensitivity and insistence on sameness (I/S) are common, co-occurring features of autism, yet the relationship between them is poorly understood. This study assessed the impact of sensory hypersensitivity on the clinical symptoms of specific phobia, separation anxiety, social anxiety and I/S for autistic and typically developing (TD) children. Parents of 79 children completed questionnaires on their child's difficulties related to sensory processing, I/S, and anxiety. Results demonstrated that sensory hypersensitivity mediated 67% of the relationship between symptoms of specific phobia and I/S and 57% of the relationship between separation anxiety and I/S...
May 24, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28506185/the-cascading-influence-of-multisensory-processing-on-speech-perception-in-autism
#2
Ryan A Stevenson, Magali Segers, Busisiwe L Ncube, Karen R Black, James M Bebko, Susanne Ferber, Morgan D Barense
It has been recently theorized that atypical sensory processing in autism relates to difficulties in social communication. Through a series of tasks concurrently assessing multisensory temporal processes, multisensory integration and speech perception in 76 children with and without autism, we provide the first behavioral evidence of such a link. Temporal processing abilities in children with autism contributed to impairments in speech perception. This relationship was significantly mediated by their abilities to integrate social information across auditory and visual modalities...
May 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28487885/novel-de-novo-variant-in-ebf3-is-likely-to-impact-dna-binding-in-a-patient-with-a-neurodevelopmental-disorder-and-expanded-phenotypes-patient-report-in-silico-functional-assessment-and-review-of-published-cases
#3
Patrick R Blackburn, Sarah S Barnett, Michael T Zimmermann, Margot A Cousin, Charu Kaiwar, Filippo Pinto E Vairo, Zhiyv Niu, Matthew J Ferber, Raul A Urrutia, Duygu Selcen, Eric W Klee, Pavel N Pichurin
Pathogenic variants in EBF3 were recently described in three back-to-back publications in association with a novel neurodevelopmental disorder characterized by intellectual disability, speech delay, ataxia, and facial dysmorphisms. In this report, we describe an additional patient carrying a de novo missense variant in EBF3 (c.487C>T, p.(Arg163Trp)) that falls within a conserved residue in the zinc knuckle motif of the DNA binding domain. Without a solved structure of the DNA binding domain, we generated a homology-based atomic model and performed molecular dynamics simulations for EBF3, which predicted decreased DNA affinity for p...
May 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28467759/nucleated-red-blood-cells-as-a-marker-of-acute-and-chronic-fetal-hypoxia-in-a-rat-model
#4
Victoria K Minior, Brian Levine, Asaf Ferber, Seth Guller, Michael Y Divon
OBJECTIVE: To examine the relationship between duration of fetal hypoxia, nucleated red blood cell (NRBC) count, and fetal growth. METHODS: Pregnant rats were exposed to a severe hypoxia (9.5%-10% O2) for varying time intervals (2, 6, 12, 24, 48, and 120 hours; n=4 for each time interval) immediately prior to delivery at term. Normoxic controls were exposed to room air (21% O2) and matched for all other study variables (n=4 rats for each time interval). Pups were delivered via hysterotomy while maintaining exposure gas concentrations...
April 28, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/28368653/lepton-flavor-dependent-angular-analysis-of-b%C3%A2-k-%C3%A2-%C3%A2
#5
S Wehle, C Niebuhr, S Yashchenko, I Adachi, H Aihara, S Al Said, D M Asner, V Aulchenko, T Aushev, R Ayad, T Aziz, V Babu, A M Bakich, V Bansal, E Barberio, W Bartel, P Behera, B Bhuyan, J Biswal, A Bobrov, A Bondar, G Bonvicini, A Bozek, M Bračko, T E Browder, D Červenkov, P Chang, V Chekelian, A Chen, B G Cheon, K Chilikin, R Chistov, K Cho, Y Choi, D Cinabro, N Dash, J Dingfelder, Z Doležal, Z Drásal, D Dutta, S Eidelman, D Epifanov, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, R Gillard, P Goldenzweig, B Golob, O Grzymkowska, E Guido, J Haba, T Hara, K Hayasaka, H Hayashii, M T Hedges, W-S Hou, C-L Hsu, T Iijima, K Inami, G Inguglia, A Ishikawa, R Itoh, Y Iwasaki, W W Jacobs, I Jaegle, H B Jeon, Y Jin, D Joffe, K K Joo, T Julius, A B Kaliyar, K H Kang, G Karyan, P Katrenko, T Kawasaki, H Kichimi, C Kiesling, D Y Kim, H J Kim, J B Kim, K T Kim, M J Kim, S H Kim, K Kinoshita, L Koch, P Kodyš, S Korpar, D Kotchetkov, P Križan, P Krokovny, T Kuhr, R Kulasiri, T Kumita, A Kuzmin, Y-J Kwon, J S Lange, C H Li, L Li, Y Li, L Li Gioi, J Libby, D Liventsev, M Lubej, T Luo, M Masuda, T Matsuda, K Miyabayashi, H Miyake, R Mizuk, G B Mohanty, T Mori, R Mussa, E Nakano, M Nakao, T Nanut, K J Nath, Z Natkaniec, M Nayak, N K Nisar, S Nishida, S Ogawa, H Ono, Y Onuki, G Pakhlova, B Pal, C-S Park, C W Park, H Park, S Paul, L Pesántez, L E Piilonen, C Pulvermacher, J Rauch, M Ritter, A Rostomyan, Y Sakai, S Sandilya, L Santelj, T Sanuki, Y Sato, V Savinov, T Schlüter, O Schneider, G Schnell, C Schwanda, A J Schwartz, Y Seino, K Senyo, O Seon, I S Seong, M E Sevior, C P Shen, T-A Shibata, J-G Shiu, B Shwartz, F Simon, R Sinha, E Solovieva, M Starič, J F Strube, K Sumisawa, T Sumiyoshi, M Takizawa, U Tamponi, F Tenchini, K Trabelsi, T Tsuboyama, M Uchida, T Uglov, Y Unno, S Uno, P Urquijo, Y Ushiroda, Y Usov, S E Vahsen, C Van Hulse, G Varner, K E Varvell, V Vorobyev, A Vossen, E Waheed, C H Wang, M-Z Wang, P Wang, M Watanabe, Y Watanabe, E Widmann, K M Williams, E Won, H Yamamoto, Y Yamashita, H Ye, Y Yook, C Z Yuan, Y Yusa, Z P Zhang, V Zhilich, V Zhukova, V Zhulanov, M Ziegler, A Zupanc
We present a measurement of angular observables and a test of lepton flavor universality in the B→K^{*}ℓ^{+}ℓ^{-} decay, where ℓ is either e or μ. The analysis is performed on a data sample corresponding to an integrated luminosity of 711  fb^{-1} containing 772×10^{6} BB[over ¯] pairs, collected at the ϒ(4S) resonance with the Belle detector at the asymmetric-energy e^{+}e^{-} collider KEKB. The result is consistent with standard model (SM) expectations, where the largest discrepancy from a SM prediction is observed in the muon modes with a local significance of 2...
March 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28339177/multisensory-speech-perception-in-autism-spectrum-disorder-from-phoneme-to-whole-word-perception
#6
Ryan A Stevenson, Sarah H Baum, Magali Segers, Susanne Ferber, Morgan D Barense, Mark T Wallace
Speech perception in noisy environments is boosted when a listener can see the speaker's mouth and integrate the auditory and visual speech information. Autistic children have a diminished capacity to integrate sensory information across modalities, which contributes to core symptoms of autism, such as impairments in social communication. We investigated the abilities of autistic and typically-developing (TD) children to integrate auditory and visual speech stimuli in various signal-to-noise ratios (SNR). Measurements of both whole-word and phoneme recognition were recorded...
March 24, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28317127/two-pathways-to-self-forgiveness-a-hedonic-path-via-self-compassion-and-a-eudaimonic-path-via-the-reaffirmation-of-violated-values
#7
Lydia Woodyatt, Michael Wenzel, Matthew Ferber
Self-forgiveness is often measured as a hedonic end-state, as the presence of positive affect and the absence of negative affect towards the self following a wrongdoing. However, self-forgiveness is also referred to as a difficult process. Self-forgiveness as a process of accepting responsibility and working through one's wrongdoing is a substantially un-hedonic - it is likely to be uncomfortable and at times painful. In this study, we examine two pathways to self-forgiveness: a hedonic focused pathway (via self-compassion) and a eudaimonic pathway (via reaffirmation of transgressed values)...
March 20, 2017: British Journal of Social Psychology
https://www.readbyqxmd.com/read/28303754/effects-of-running-experience-on-coordination-and-its-variability-in-runners
#8
Pablo Floría, Alberto Sánchez-Sixto, Reed Ferber, Andrew J Harrison
The purpose of this study was to examine the differences in coordination variability in running gait between trained runners and non-runners using continuous relative phase (CRP) analysis. Lower extremity kinematic data were collected for 22 participants during the stance phase. The participants were assigned to either a runner or non-runner group based on running volume training. Segment coordination and coordination variability were calculated for selected hip-knee and knee-ankle couplings. Independent t-tests and magnitude-based inferences were used to compare the 2 groups...
March 17, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28277107/gender-age-and-time-dependent-dosing-of-growth-hormone-in-adults-real-world-data-from-a-decade-of-clinical-practice-in-germany
#9
Peter H Kann, Simona Bergmann, Günter K Stalla, Christina Dimopoulou, Matthias M Weber, Birgitte T Pedersen, Stefanie Meckes-Ferber
We evaluated treatment patterns and gender-dependent dosing of growth hormone (GH) substitution in adults with GH deficiency (AGHD). Data on GH dose were collected (2003-2013) from 509 GH-treated patients (mean age: 48.9 years; 47% female) enroled in the observational German NordiWin study (NCT01543880). The impact of gender, age, treatment duration and calendar year on GH treatment patterns was evaluated by multiple regression analysis. Mean (SD) baseline GH dose (mg/day) was similar between females (0...
March 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28253053/kinematic-gait-patterns-in-competitive-and-recreational-runners
#10
Christian A Clermont, Sean T Osis, Angkoon Phinyomark, Reed Ferber
Certain homogeneous running subgroups demonstrate distinct kinematic patterns in running; however, the running mechanics of competitive and recreational runners are not well understood. Therefore, the purpose of this study was to determine whether we could separate and classify competitive and recreational runners according to gait kinematics using multivariate analyses and a machine learning approach. Participants were allocated to the 'competitive' (n=20) or 'recreational' group (n=15) based on age, gender, and recent race performance...
March 2, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28211706/observation-of-d-0-%C3%A2-%C3%AF-0-%C3%AE-and-search-for-cp-violation-in-radiative-charm-decays
#11
T Nanut, A Zupanc, I Adachi, H Aihara, S Al Said, D M Asner, V Aulchenko, T Aushev, R Ayad, V Babu, I Badhrees, A M Bakich, V Bansal, P Behera, V Bhardwaj, J Biswal, A Bondar, A Bozek, M Bračko, T E Browder, D Červenkov, V Chekelian, A Chen, B G Cheon, R Chistov, K Cho, S-K Choi, Y Choi, D Cinabro, N Dash, S Di Carlo, Z Doležal, D Dutta, S Eidelman, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, R Gillard, P Goldenzweig, B Golob, K Hayasaka, H Hayashii, W-S Hou, T Iijima, K Inami, G Inguglia, A Ishikawa, Y Iwasaki, W W Jacobs, I Jaegle, D Joffe, K K Joo, T Julius, A B Kaliyar, K H Kang, T Kawasaki, D Y Kim, J B Kim, K T Kim, M J Kim, S H Kim, K Kinoshita, P Kodyš, S Korpar, P Krokovny, T Kuhr, R Kulasiri, A Kuzmin, Y-J Kwon, J S Lange, I S Lee, C H Li, L Li, Y Li, L Li Gioi, J Libby, D Liventsev, M Lubej, M Masuda, T Matsuda, D Matvienko, K Miyabayashi, H Miyata, R Mizuk, G B Mohanty, H K Moon, M Nakao, K J Nath, M Nayak, N K Nisar, S Nishida, S Ogawa, S Okuno, P Pakhlov, G Pakhlova, B Pal, C-S Park, C W Park, H Park, S Paul, T K Pedlar, L Pesántez, R Pestotnik, M Petrič, L E Piilonen, K Prasanth, C Pulvermacher, J Rauch, M Ritter, A Rostomyan, Y Sakai, S Sandilya, L Santelj, T Sanuki, Y Sato, V Savinov, T Schlüter, O Schneider, G Schnell, C Schwanda, A J Schwartz, Y Seino, K Senyo, O Seon, M E Sevior, V Shebalin, C P Shen, T-A Shibata, J-G Shiu, B Shwartz, E Solovieva, S Stanič, M Starič, J F Strube, J Stypula, T Sumiyoshi, M Takizawa, U Tamponi, F Tenchini, K Trabelsi, M Uchida, S Uno, Y Ushiroda, G Varner, A Vinokurova, V Vorobyev, A Vossen, C H Wang, M-Z Wang, P Wang, Y Watanabe, E Widmann, E Won, J Yamaoka, Y Yamashita, J Yelton, Z P Zhang, V Zhilich, V Zhukova, V Zhulanov
We report the first observation of the radiative charm decay D^{0}→ρ^{0}γ and the first search for CP violation in decays D^{0}→ρ^{0}γ, ϕγ, and K[over ¯]^{*0}(892)γ, using a data sample of 943  fb^{-1} collected with the Belle detector at the KEKB asymmetric-energy e^{+}e^{-} collider. The branching fraction is measured to be B(D^{0}→ρ^{0}γ)=(1.77±0.30±0.07)×10^{-5}, where the first uncertainty is statistical and the second is systematic. The obtained CP asymmetries A_{CP}(D^{0}→ρ^{0}γ)=+0...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28196094/innate-immunity-mediated-longevity-and-longevity-induced-by-germ-cell-removal-converge-on-the-c-type-lectin-domain-protein-irg-7
#12
Elad Yunger, Modi Safra, Mor Levi-Ferber, Anat Haviv-Chesner, Sivan Henis-Korenblit
In C. elegans, removal of the germline triggers molecular events in the neighboring intestine, which sends an anti-aging signal to the rest of the animal. In this study, we identified an innate immunity related gene, named irg-7, as a novel mediator of longevity in germlineless animals. We consider irg-7 to be an integral downstream component of the germline longevity pathway because its expression increases upon germ cell removal and its depletion interferes with the activation of the longevity-promoting transcription factors DAF-16 and DAF-12 in germlineless animals...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28077442/miniaturized-nanopore-dna-sequencing-accelerating-the-path-to-precision-medicine
#13
Linnea M Baudhuin, Matthew J Ferber
No abstract text is available yet for this article.
January 11, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/27904794/pain-function-and-strength-outcomes-for-males-and-females-with-patellofemoral-pain-who-participate-in-either-a-hip-core-or-knee-based-rehabilitation-program
#14
Lori A Bolgla, Jennifer Earl-Boehm, Carolyn Emery, Karrie Hamstra-Wright, Reed Ferber
BACKGROUND: Hip exercise has been recommended for females with patellofemoral pain (PFP). It is unknown if males with PFP will benefit from a similar treatment strategy. HYPOTHESES/PURPOSE: The purpose of this study was to compare improvements in pain, function, and strength between males and females with PFP who participated in either a hip/core or knee rehabilitation program. The directional hypothesis was that females would respond more favorably to the hip/core rehabilitation program and males to the knee program...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27889189/reliability-of-gait-analysis-using-wearable-sensors-in-patients-with-knee-osteoarthritis
#15
Dylan Kobsar, Sean T Osis, Angkoon Phinyomark, Jeffrey E Boyd, Reed Ferber
The aim of this study was to determine the test-retest reliability of linear acceleration waveforms collected at the low back, thigh, shank, and foot during walking, in a cohort of knee osteoarthritis patients, by applying two separate sensor attitude correction methods (static attitude correction and dynamic attitude correction). Linear acceleration data were collected on the subjects׳ most affected limb during treadmill walking on two separate days. Results reveal all attitude corrected acceleration waveforms displayed high repeatability, with coefficient of multiple determination values ranging from 0...
December 8, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27872236/preclinical-and-early-clinical-profile-of-a-highly-selective-and-potent-oral-inhibitor-of-aldosterone-synthase-cyp11b2
#16
Katrijn Bogman, Dietmar Schwab, Marie-Laure Delporte, Giuseppe Palermo, Kurt Amrein, Susanne Mohr, Maria Cristina De Vera Mudry, Morris J Brown, Philippe Ferber
Primary hyperaldosteronism is a common cause of resistant hypertension. Aldosterone is produced in the adrenal by aldosterone synthase (AS, encoded by the gene CYP11B2). AS shares 93% homology to 11β-hydroxylase (encoded by the gene CYP11B1), responsible for cortisol production. This homology has hitherto impeded the development of a drug, which selectively suppresses aldosterone but not cortisol production, as a new treatment for primary hyperaldosteronism. We now report the development of RO6836191 as a potent (Ki 13 nmol/L) competitive inhibitor of AS, with in vitro selectivity >100-fold over 11β-hydroxylase...
January 2017: Hypertension
https://www.readbyqxmd.com/read/27815091/infection-and-antibiotic-use-in-infancy-and-risk-of-childhood-obesity-a-longitudinal-birth-cohort-study
#17
De-Kun Li, Hong Chen, Jeannette Ferber, Roxana Odouli
BACKGROUND: Data from previous studies have suggested a possible association between antibiotic use in infancy and risk of childhood obesity, with implications for health-care delivery and obesity prevention strategies. However, whether the observed association was due to antibiotic use or underlying infection, or both, is unclear. We aimed to disentangle the effect of antibiotic use in infancy from that of underlying infection on the risk of childhood obesity. METHODS: In this longitudinal birth cohort study, we included infants in the Kaiser Permanente Northern California population born between Jan 1, 1997, and March 31, 2013...
January 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27814971/gait-biomechanics-in-the-era-of-data-science
#18
Reed Ferber, Sean T Osis, Jennifer L Hicks, Scott L Delp
Data science has transformed fields such as computer vision and economics. The ability of modern data science methods to extract insights from large, complex, heterogeneous, and noisy datasets is beginning to provide a powerful complement to the traditional approaches of experimental motion capture and biomechanical modeling. The purpose of this article is to provide a perspective on how data science methods can be incorporated into our field to advance our understanding of gait biomechanics and improve treatment planning procedures...
December 8, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27811081/reactive-electrophilic-oxylipins-trigger-a-heat-stress-like-response-through-hsfa1-transcription-factors
#19
Miriam Muench, Chih-Hsuan Hsin, Elena Ferber, Susanne Berger, Martin J Mueller
Abiotic and biotic stresses are often characterized by an induction of reactive electrophile species (RES) such as the jasmonate 12-oxo-phytodienoic acid (OPDA) or the structurally related phytoprostanes. Previously, RES oxylipins have been shown massively to induce heat-shock-response (HSR) genes including HSP101 chaperones. Moreover, jasmonates have been reported to play a role in basal thermotolerance. We show that representative HSR marker genes are strongly induced by RES oxylipins through the four master regulator transcription factors HSFA1a, b, d, and e essential for short-term adaptation to heat stress in Arabidopsis...
November 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27792664/universal-shape-characteristics-for-the-mesoscopic-polymer-chain-via-dissipative-particle-dynamics
#20
O Kalyuzhnyi, J M Ilnytskyi, Yu Holovatch, C von Ferber
In this paper we study the shape characteristics of a polymer chain in a good solvent using a mesoscopic level of modelling. The dissipative particle dynamics simulations are performed in 3D space at a range of chain lengths N. The scaling laws for the end-to-end distance and gyration radius are examined first and found to hold for [Formula: see text] yielding a reasonably accurate value for the Flory exponent ν. Within the same interval of chain lengths, the asphericity, prolateness and some other shape characteristics of the chain are found to become independent of N...
October 28, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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