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https://www.readbyqxmd.com/read/29077638/gait-kinematics-in-individuals-with-acute-and-chronic-patellofemoral-pain
#1
Aaron Fox, Reed Ferber, Natalie Saunders, Sean Osis, Jason Bonacci
PURPOSE: This study aimed to identify the discriminating kinematic gait characteristics between individuals with acute and chronic patellofemoral pain (PFP), and healthy controls. METHODS: Ninety-eight runners with PFP (39 male, 59 female) and 98 healthy control runners (38 male, 60 female) ran on a treadmill at a self-selected speed while three-dimensional lower limb kinematic data were collected. Runners with PFP were split into acute (n = 25) and chronic (n = 73) sub-groups based on whether they had been experiencing pain for less or greater than three months, respectively...
October 26, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28976305/co-targeting-the-tumor-endothelium-and-p-selectin-expressing-glioblastoma-cells-leads-to-a-remarkable-therapeutic-outcome
#2
Shiran Ferber, Galia Tiram, Ana Sousa-Herves, Anat Eldar-Boock, Adva Krivitsky, Anna Scomparin, Eilam Yeini, Paula Ofek, Dikla Ben-Shushan, Laura Isabel Vossen, Kai Licha, Rachel Grossman, Zvi Ram, Jack Henkin, Eytan Ruppin, Noam Auslander, Rainer Haag, Marcelo Calderón, Ronit Satchi-Fainaro
Glioblastoma is a highly aggressive brain tumor. Current standard-of-care results in a marginal therapeutic outcome, partly due to acquirement of resistance and insufficient blood-brain barrier (BBB) penetration of chemotherapeutics. To circumvent these limitations, we conjugated the chemotherapy paclitaxel (PTX) to a dendritic polyglycerol sulfate (dPGS) nanocarrier. dPGS is able to cross the BBB, bind to P/L-selectins and accumulate selectively in intracranial tumors. We show that dPGS has dual targeting properties, as we found that P-selectin is not only expressed on tumor endothelium but also on glioblastoma cells...
October 4, 2017: ELife
https://www.readbyqxmd.com/read/28963436/novel-nr2f1-variants-likely-disrupt-dna-binding-molecular-modeling-in-two-cases-review-of-published-cases-genotype-phenotype-correlation-and-phenotypic-expansion-of-the-bosch-boonstra-schaaf-optic-atrophy-syndrome
#3
Charu Kaiwar, Michael T Zimmerman, Matthew J Ferber, Zhiyv Niu, Raul A Urrutia, Eric W Klee, Dusica Babovic-Vuksanovic
Bosch-Boonstra-Schaaf Optic Atrophy Syndrome (BBSOAS) is a recently described autosomal dominant disorder caused by mutations in NR2F1 gene. There are presently 28 cases of BBSOAS described in the literature. Its common features include developmental delay, intellectual disability, hypotonia, optic nerve atrophy, attention deficit disorder, autism spectrum disorder, seizures, hearing defects, spasticity and thinning of the corpus callosum. Here we report two unrelated probands with novel, de novo, missense variants in NR2F1 The first is a 14-year-old male patient with hypotonia, intellectual disability, optic nerve hypoplasia, delayed bone age, short stature, and altered neurotransmitter levels on CSF testing...
September 28, 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28951922/molecular-design-of-melt-spinnable-co-polymers-as-si-b-c-n-fiber-precursors
#4
Antoine Viard, Laura Gottardo, David Lopez-Ferber, Anne Soleilhavoup, Chrystelle Salameh, Sneha Samal, Yann Gueguen, Tanguy Rouxel, Günter Motz, Florence Babonneau, Christel Gervais, Samuel Bernard
Two series of co-polymers with the general formula [B(C2H4SiCH3(NH)x(NCH3)y)3]n, i.e., composed of C2H4SiCH3(NH)x and C2H4SiCH3(NCH3)y (C2H4 = CHCH3, CH2CH2) building blocks in a well defined x : y ratio, have been synthesized by hydroboration of dichloromethylvinylsilane with borane dimethyl sulfide followed by successive reactions with lithium amide and methylamine according to controlled ratios. The role of the chemistry behind their syntheses has been studied in detail by solid-state NMR, FT-IR and elemental analyses...
October 10, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28944238/targeted-sequencing-of-36-known-or-putative-colorectal-cancer-susceptibility-genes
#5
Melissa S DeRycke, Shanaka Gunawardena, Jessica R Balcom, Angela M Pickart, Lindsey A Waltman, Amy J French, Shannon McDonnell, Shaun M Riska, Zachary C Fogarty, Melissa C Larson, Sumit Middha, Bruce W Eckloff, Yan W Asmann, Matthew J Ferber, Robert W Haile, Steven Gallinger, Mark Clendenning, Christophe Rosty, Aung K Win, Daniel D Buchanan, John L Hopper, Polly A Newcomb, Loic Le Marchand, Ellen L Goode, Noralane M Lindor, Stephen N Thibodeau
BACKGROUND: Mutations in several genes predispose to colorectal cancer. Genetic testing for hereditary colorectal cancer syndromes was previously limited to single gene tests; thus, only a very limited number of genes were tested, and rarely those infrequently mutated in colorectal cancer. Next-generation sequencing technologies have made it possible to sequencing panels of genes known and suspected to influence colorectal cancer susceptibility. METHODS: Targeted sequencing of 36 known or putative CRC susceptibility genes was conducted for 1231 CRC cases from five subsets: (1) Familial Colorectal Cancer Type X (n = 153); (2) CRC unselected by tumor immunohistochemical or microsatellite stability testing (n = 548); (3) young onset (age <50 years) (n = 333); (4) proficient mismatch repair (MMR) in cases diagnosed at ≥50 years (n = 68); and (5) deficient MMR CRCs with no germline mutations in MLH1, MSH2, MSH6, or PMS2 (n = 129)...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28933892/erasing-and-blurring-memories-the-differential-impact-of-interference-on-separate-aspects-of-forgetting
#6
Sol Z Sun, Celia Fidalgo, Morgan D Barense, Andy C H Lee, Jonathan S Cant, Susanne Ferber
Interference disrupts information processing across many timescales, from immediate perception to memory over short and long durations. The widely held similarity assumption states that as similarity between interfering information and memory contents increases, so too does the degree of impairment. However, information is lost from memory in different ways. For instance, studied content might be erased in an all-or-nothing manner. Alternatively, information may be retained but the precision might be degraded or blurred...
September 21, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28910657/the-use-of-real-time-feedback-to-improve-kinematic-marker-placement-consistency-among-novice-examiners
#7
Charles A J Macaulay, Sean T Osis, Christian Clermont, Reed Ferber
Marker placement deviation has been shown to be the largest source of error in gait kinematic data, limiting the ability of clinicians and researchers to conduct between-day or between-center investigations. Prior marker-placement standardization methods are either impractical for a clinical setting or rely on expert marker placement. However, a recently developed, real-time feedback tool has been developed and shown to improve marker placement and downstream kinematic calculations. The purpose of this study was to determine whether this real-time marker-placement tool could improve the consistency of gait kinematic data collected by a group of novice examiners...
October 2017: Gait & Posture
https://www.readbyqxmd.com/read/28899433/wearable-sensors-to-predict-improvement-following-an-exercise-intervention-in-patients-with-knee-osteoarthritis
#8
Dylan Kobsar, Sean T Osis, Jeffrey E Boyd, Blayne A Hettinga, Reed Ferber
BACKGROUND: Muscle strengthening exercises consistently demonstrate improvements in the pain and function of adults with knee osteoarthritis, but individual response rates can vary greatly. Identifying individuals who are more likely to respond is important in developing more efficient rehabilitation programs for knee osteoarthritis. Therefore, the purpose of this study was to determine if pre-intervention multi-sensor accelerometer data (e.g., back, thigh, shank, foot accelerometers) and patient reported outcome measures (e...
September 12, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28833240/estimation-of-the-power-of-the-food-effect-on-qtc-to-show-assay-sensitivity
#9
Georg Ferber, Sara Fernandes, Jörg Täubel
The most recent International Conference on Harmonisation E14 Q&A document states that a separate positive control would not be necessary provided sufficiently high exposures are achieved in the early-phase studies. Realistically, a phase 1 study is unlikely to include a pharmacological positive control, and in cases in which plasma levels of the drug exceeding therapeutic levels are not achieved, the lack of a positive control can constitute a limitation when excluding an effect of regulatory concern. It has been proposed to use the effect of a standardized meal on the estimate of the diurnal time course of QTc to show assay sensitivity...
August 17, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28763575/cardiac-safety-of-rupatadine-in-a-single-ascending-dose-and-multiple-ascending-dose-study-in-healthy-japanese-subjects-using-intensive-electrocardiogram-assessments-comparison-with-the-previous-white-caucasian-thorough-qt-study
#10
J Täubel, G Ferber, S Fernandes, E Santamaría, I Izquierdo
A thorough QT/QTc study in healthy white Caucasian subjects demonstrated that rupatadine has no proarrhythmic potential and raised no cardiac safety concerns. The present phase 1 study aimed to confirm the cardiac safety of rupatadine in healthy Japanese subjects. In this randomized, double-blind, placebo-controlled study, 27 healthy Japanese subjects were administered single and multiple escalating rupatadine doses of 10, 20, and 40 mg or placebo. Triplicate electrocardiogram (ECG) recordings were performed on days -1, 1, and 5 at several points, and time-matched pharmacokinetic samples were also collected...
August 1, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28759445/estimation-of-water-quality-by-uv-vis-spectrometry-in-the-framework-of-treated-wastewater-reuse
#11
Erwan Carré, Jean Pérot, Vincent Jauzein, Liming Lin, Miguel Lopez-Ferber
The aim of this study is to investigate the potential of ultraviolet/visible (UV/Vis) spectrometry as a complementary method for routine monitoring of reclaimed water production. Robustness of the models and compliance of their sensitivity with current quality limits are investigated. The following indicators are studied: total suspended solids (TSS), turbidity, chemical oxygen demand (COD) and nitrate. Partial least squares regression (PLSR) is used to find linear correlations between absorbances and indicators of interest...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28671821/the-t-cell-receptor-can-bind-to-the-peptide-bound-major-histocompatibility-complex-and-uncomplexed-%C3%AE-2-microglobulin-through-distinct-binding-sites
#12
Patrick S Merkle, Melita Irving, Song Hongjian, Mathias Ferber, Thomas J D Jørgensen, Kirsten Scholten, Immanuel Luescher, George Coukos, Vincent Zoete, Michel A Cuendet, Olivier Michielin, Kasper D Rand
T-Cell receptor (TCR)-mediated recognition of the peptide-bound major histocompatibility complex (pMHC) initiates an adaptive immune response against antigen-presenting target cells. The recognition events take place at the TCR-pMHC interface, and their effects on TCR conformation and dynamics are controversial. Here, we have measured the time-resolved hydrogen/deuterium exchange (HDX) of a soluble TCR in the presence and absence of its cognate pMHC by mass spectrometry to delineate the impact of pMHC binding on solution-phase structural dynamics in the TCR...
August 1, 2017: Biochemistry
https://www.readbyqxmd.com/read/28647484/neural-representation-of-geometry-and-surface-properties-in-object-and-scene-perception
#13
Matthew X Lowe, Jason Rajsic, Jason P Gallivan, Susanne Ferber, Jonathan S Cant
Multiple cortical regions are crucial for perceiving the visual world, yet the processes shaping representations in these regions are unclear. To address this issue, we must elucidate how perceptual features shape representations of the environment. Here, we explore how the weighting of different visual features affects neural representations of objects and scenes, focusing on the scene-selective parahippocampal place area (PPA), but additionally including the retrosplenial complex (RSC), occipital place area (OPA), lateral occipital (LO) area, fusiform face area (FFA) and occipital face area (OFA)...
June 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/28617903/association-between-patient-review-of-systems-score-and-somatization
#14
Tyler Stephen Okland, Joseph Robert Gonzalez, Alexander Thomas Ferber, Scott Edward Mann
Importance: Somatization is a condition in which psychological distress is manifested by medically unexplained symptoms, and it is prevalent in all medical specialties, including otolaryngology. Recognition of somatization can be difficult, and there are limited methods available. Objectives: To determine whether patients with somatization respond differently to the review of systems (ROS) portion of the patient interview and whether the ROS can be used to identify patients with somatization...
September 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28612353/life-cycle-assessment-case-study-tertiary-treatment-process-options-for-wastewater-reuse
#15
Erwan Carré, Joana Beigbeder, Vincent Jauzein, Guillaume Junqua, Miguel Lopez-Ferber
Tertiary treatment process (including filtration and/or disinfection) is necessary to obtain a water quality suited for high-quality reuse from wastewater treatment. Industrial pilots representing small real-size treatment units were set up downstream of a conventional secondary treatment of a wastewater treatment plant in the South of France and their performance followed for 2 y. Life cycle assessment (LCA) methodology is used to compare the environmental impacts of different treatment processes. Five tertiary treatment trains were studied: 1) sand filtration (SF) + storage followed by ultraviolet (UV) dynamic reactor disinfection (SF-UVD), 2) sand filtration + UV batch reactor disinfection (SF-UVB), 3) ultrafiltration (UF), 4) ultrafiltration and UV batch reactor disinfection (UF-UVB), and 5) microfiltration (MF) and storage followed by dynamic UV disinfection (MF-UVD)...
November 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28598663/measurement-of-the-%C3%AF-lepton-polarization-and-r-d-in-the-decay-b-over-%C3%A2-%C3%A2-d-%C3%AF-%C3%AE-over-%C3%A2-_-%C3%AF
#16
S Hirose, T Iijima, I Adachi, K Adamczyk, H Aihara, S Al Said, D M Asner, H Atmacan, V Aulchenko, T Aushev, R Ayad, V Babu, I Badhrees, A M Bakich, V Bansal, E Barberio, P Behera, M Berger, B Bhuyan, J Biswal, A Bondar, G Bonvicini, A Bozek, M Bračko, T E Browder, D Červenkov, P Chang, A Chen, B G Cheon, K Chilikin, R Chistov, K Cho, Y Choi, D Cinabro, M Danilov, N Dash, S Di Carlo, J Dingfelder, Z Doležal, Z Drásal, D Dutta, S Eidelman, D Epifanov, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, P Goldenzweig, B Golob, D Greenwald, J Grygier, J Haba, K Hara, J Hasenbusch, K Hayasaka, H Hayashii, T Higuchi, W-S Hou, C-L Hsu, K Inami, G Inguglia, A Ishikawa, R Itoh, Y Iwasaki, W W Jacobs, I Jaegle, Y Jin, D Joffe, K K Joo, T Julius, Y Kato, T Kawasaki, H Kichimi, C Kiesling, D Y Kim, J B Kim, K T Kim, M J Kim, S H Kim, K Kinoshita, P Kodyš, S Korpar, D Kotchetkov, P Križan, P Krokovny, T Kuhr, R Kulasiri, R Kumar, Y-J Kwon, J S Lange, C H Li, L Li, Y Li, L Li Gioi, J Libby, D Liventsev, M Lubej, T Luo, J MacNaughton, M Masuda, T Matsuda, D Matvienko, K Miyabayashi, H Miyake, H Miyata, R Mizuk, G B Mohanty, H K Moon, T Mori, R Mussa, M Nakao, T Nanut, K J Nath, Z Natkaniec, M Nayak, M Niiyama, N K Nisar, S Nishida, S Ogawa, S Okuno, H Ono, Y Onuki, W Ostrowicz, P Pakhlov, G Pakhlova, B Pal, C W Park, H Park, S Paul, L Pesántez, R Pestotnik, L E Piilonen, K Prasanth, M Ritter, A Rostomyan, M Rozanska, Y Sakai, S Sandilya, L Santelj, T Sanuki, Y Sato, V Savinov, T Schlüter, O Schneider, G Schnell, C Schwanda, Y Seino, K Senyo, O Seon, M E Sevior, V Shebalin, C P Shen, T-A Shibata, J-G Shiu, F Simon, A Sokolov, E Solovieva, M Starič, J F Strube, K Sumisawa, T Sumiyoshi, M Takizawa, U Tamponi, F Tenchini, K Trabelsi, M Uchida, T Uglov, Y Unno, S Uno, P Urquijo, Y Ushiroda, Y Usov, C Van Hulse, G Varner, K E Varvell, A Vossen, C H Wang, M-Z Wang, P Wang, M Watanabe, Y Watanabe, E Widmann, E Won, Y Yamashita, H Ye, J Yelton, C Z Yuan, Z P Zhang, V Zhilich, V Zhulanov, A Zupanc
We report the first measurement of the τ lepton polarization P_{τ}(D^{*}) in the decay B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ} as well as a new measurement of the ratio of the branching fractions R(D^{*})=B(B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]→D^{*}ℓ^{-}ν[over ¯]_{ℓ}), where ℓ^{-} denotes an electron or a muon, and the τ is reconstructed in the modes τ^{-}→π^{-}ν_{τ} and τ^{-}→ρ^{-}ν_{τ}. We use the full data sample of 772×10^{6}  BB[over ¯] pairs recorded with the Belle detector at the KEKB electron-positron collider...
May 26, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28540453/linking-anxiety-and-insistence-on-sameness-in-autistic-children-the-role-of-sensory-hypersensitivity
#17
Karen R Black, Ryan A Stevenson, Magali Segers, Busiswe L Ncube, Sol Z Sun, Aviva Philipp-Muller, James M Bebko, Morgan D Barense, Susanne Ferber
Sensory hypersensitivity and insistence on sameness (I/S) are common, co-occurring features of autism, yet the relationship between them is poorly understood. This study assessed the impact of sensory hypersensitivity on the clinical symptoms of specific phobia, separation anxiety, social anxiety and I/S for autistic and typically developing (TD) children. Parents of 79 children completed questionnaires on their child's difficulties related to sensory processing, I/S, and anxiety. Results demonstrated that sensory hypersensitivity mediated 67% of the relationship between symptoms of specific phobia and I/S and 57% of the relationship between separation anxiety and I/S...
August 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28506185/the-cascading-influence-of-multisensory-processing-on-speech-perception-in-autism
#18
Ryan A Stevenson, Magali Segers, Busisiwe L Ncube, Karen R Black, James M Bebko, Susanne Ferber, Morgan D Barense
It has been recently theorized that atypical sensory processing in autism relates to difficulties in social communication. Through a series of tasks concurrently assessing multisensory temporal processes, multisensory integration and speech perception in 76 children with and without autism, we provide the first behavioral evidence of such a link. Temporal processing abilities in children with autism contributed to impairments in speech perception. This relationship was significantly mediated by their abilities to integrate social information across auditory and visual modalities...
May 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28487885/novel-de-novo-variant-in-ebf3-is-likely-to-impact-dna-binding-in-a-patient-with-a-neurodevelopmental-disorder-and-expanded-phenotypes-patient-report-in-silico-functional-assessment-and-review-of-published-cases
#19
Patrick R Blackburn, Sarah S Barnett, Michael T Zimmermann, Margot A Cousin, Charu Kaiwar, Filippo Pinto E Vairo, Zhiyv Niu, Matthew J Ferber, Raul A Urrutia, Duygu Selcen, Eric W Klee, Pavel N Pichurin
Pathogenic variants in EBF3 were recently described in three back-to-back publications in association with a novel neurodevelopmental disorder characterized by intellectual disability, speech delay, ataxia, and facial dysmorphisms. In this report, we describe an additional patient carrying a de novo missense variant in EBF3 (c.487C>T, p.(Arg163Trp)) that falls within a conserved residue in the zinc knuckle motif of the DNA binding domain. Without a solved structure of the DNA binding domain, we generated a homology-based atomic model and performed molecular dynamics simulations for EBF3, which predicted decreased DNA affinity for p...
May 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28467759/nucleated-red-blood-cells-as-a-marker-of-acute-and-chronic-fetal-hypoxia-in-a-rat-model
#20
Victoria K Minior, Brian Levine, Asaf Ferber, Seth Guller, Michael Y Divon
OBJECTIVE: To examine the relationship between duration of fetal hypoxia, nucleated red blood cell (NRBC) count, and fetal growth. METHODS: Pregnant rats were exposed to a severe hypoxia (9.5%-10% O2) for varying time intervals (2, 6, 12, 24, 48, and 120 hours; n=4 for each time interval) immediately prior to delivery at term. Normoxic controls were exposed to room air (21% O2) and matched for all other study variables (n=4 rats for each time interval). Pups were delivered via hysterotomy while maintaining exposure gas concentrations...
April 28, 2017: Rambam Maimonides Medical Journal
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