keyword
MENU ▼
Read by QxMD icon Read
search

Ferber

keyword
https://www.readbyqxmd.com/read/28647484/neural-representation-of-geometry-and-surface-properties-in-object-and-scene-perception
#1
Matthew X Lowe, Jason Rajsic, Jason P Gallivan, Susanne Ferber, Jonathan S Cant
Multiple cortical regions are crucial for perceiving the visual world, yet the processes shaping representations in these regions are unclear. To address this issue, we must elucidate how perceptual features shape representations of the environment. Here, we explore how the weighting of different visual features affects neural representations of objects and scenes, focusing on the scene-selective parahippocampal place area (PPA), but additionally including the retrosplenial complex (RSC), occipital place area (OPA), lateral occipital (LO) area, fusiform face area (FFA) and occipital face area (OFA)...
June 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/28617903/association-between-patient-review-of-systems-score-and-somatization
#2
Tyler Stephen Okland, Joseph Robert Gonzalez, Alexander Thomas Ferber, Scott Edward Mann
Importance: Somatization is a condition in which psychological distress is manifested by medically unexplained symptoms, and it is prevalent in all medical specialties, including otolaryngology. Recognition of somatization can be difficult, and there are limited methods available. Objectives: To determine whether patients with somatization respond differently to the review of systems (ROS) portion of the patient interview and whether the ROS can be used to identify patients with somatization...
June 15, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28612353/lca-case-study-tertiary-treatment-process-options-for-wastewater-reuse
#3
Erwan Carré, Joana Beigbeder, Vincent Jauzein, Guillaume Junqua, Miguel Lopez-Ferber
Tertiary treatment process (including filtration and/or disinfection) is necessary to obtain a water quality suited for high-quality reuse from wastewater treatment. Industrial pilots representing small real size treatment units were set up downstream of a conventional secondary treatment of a wastewater treatment plant in the South of France and their performance followed for two years. Life-cycle assessment (LCA) methodology is used to compare the environmental impacts of different treatment processes. Five tertiary treatment trains were studied: 1) sand filtration + storage followed by ultraviolet (UV) dynamic reactor disinfection (SF-UVD), 2) sand filtration (SF) + UV batch reactor disinfection (SF-UVB), 3) ultrafiltration (UF), 4) ultrafiltration and UV batch reactor disinfection (UF-UVB), 5) microfiltration (MF) and storage followed by dynamic UV disinfection (MF-UVD)...
June 13, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28598663/measurement-of-the-%C3%AF-lepton-polarization-and-r-d-in-the-decay-b-over-%C3%A2-%C3%A2-d-%C3%AF-%C3%AE-over-%C3%A2-_-%C3%AF
#4
S Hirose, T Iijima, I Adachi, K Adamczyk, H Aihara, S Al Said, D M Asner, H Atmacan, V Aulchenko, T Aushev, R Ayad, V Babu, I Badhrees, A M Bakich, V Bansal, E Barberio, P Behera, M Berger, B Bhuyan, J Biswal, A Bondar, G Bonvicini, A Bozek, M Bračko, T E Browder, D Červenkov, P Chang, A Chen, B G Cheon, K Chilikin, R Chistov, K Cho, Y Choi, D Cinabro, M Danilov, N Dash, S Di Carlo, J Dingfelder, Z Doležal, Z Drásal, D Dutta, S Eidelman, D Epifanov, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, P Goldenzweig, B Golob, D Greenwald, J Grygier, J Haba, K Hara, J Hasenbusch, K Hayasaka, H Hayashii, T Higuchi, W-S Hou, C-L Hsu, K Inami, G Inguglia, A Ishikawa, R Itoh, Y Iwasaki, W W Jacobs, I Jaegle, Y Jin, D Joffe, K K Joo, T Julius, Y Kato, T Kawasaki, H Kichimi, C Kiesling, D Y Kim, J B Kim, K T Kim, M J Kim, S H Kim, K Kinoshita, P Kodyš, S Korpar, D Kotchetkov, P Križan, P Krokovny, T Kuhr, R Kulasiri, R Kumar, Y-J Kwon, J S Lange, C H Li, L Li, Y Li, L Li Gioi, J Libby, D Liventsev, M Lubej, T Luo, J MacNaughton, M Masuda, T Matsuda, D Matvienko, K Miyabayashi, H Miyake, H Miyata, R Mizuk, G B Mohanty, H K Moon, T Mori, R Mussa, M Nakao, T Nanut, K J Nath, Z Natkaniec, M Nayak, M Niiyama, N K Nisar, S Nishida, S Ogawa, S Okuno, H Ono, Y Onuki, W Ostrowicz, P Pakhlov, G Pakhlova, B Pal, C W Park, H Park, S Paul, L Pesántez, R Pestotnik, L E Piilonen, K Prasanth, M Ritter, A Rostomyan, M Rozanska, Y Sakai, S Sandilya, L Santelj, T Sanuki, Y Sato, V Savinov, T Schlüter, O Schneider, G Schnell, C Schwanda, Y Seino, K Senyo, O Seon, M E Sevior, V Shebalin, C P Shen, T-A Shibata, J-G Shiu, F Simon, A Sokolov, E Solovieva, M Starič, J F Strube, K Sumisawa, T Sumiyoshi, M Takizawa, U Tamponi, F Tenchini, K Trabelsi, M Uchida, T Uglov, Y Unno, S Uno, P Urquijo, Y Ushiroda, Y Usov, C Van Hulse, G Varner, K E Varvell, A Vossen, C H Wang, M-Z Wang, P Wang, M Watanabe, Y Watanabe, E Widmann, E Won, Y Yamashita, H Ye, J Yelton, C Z Yuan, Z P Zhang, V Zhilich, V Zhulanov, A Zupanc
We report the first measurement of the τ lepton polarization P_{τ}(D^{*}) in the decay B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ} as well as a new measurement of the ratio of the branching fractions R(D^{*})=B(B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]→D^{*}ℓ^{-}ν[over ¯]_{ℓ}), where ℓ^{-} denotes an electron or a muon, and the τ is reconstructed in the modes τ^{-}→π^{-}ν_{τ} and τ^{-}→ρ^{-}ν_{τ}. We use the full data sample of 772×10^{6}  BB[over ¯] pairs recorded with the Belle detector at the KEKB electron-positron collider...
May 26, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28540453/linking-anxiety-and-insistence-on-sameness-in-autistic-children-the-role-of-sensory-hypersensitivity
#5
Karen R Black, Ryan A Stevenson, Magali Segers, Busiswe L Ncube, Sol Z Sun, Aviva Philipp-Muller, James M Bebko, Morgan D Barense, Susanne Ferber
Sensory hypersensitivity and insistence on sameness (I/S) are common, co-occurring features of autism, yet the relationship between them is poorly understood. This study assessed the impact of sensory hypersensitivity on the clinical symptoms of specific phobia, separation anxiety, social anxiety and I/S for autistic and typically developing (TD) children. Parents of 79 children completed questionnaires on their child's difficulties related to sensory processing, I/S, and anxiety. Results demonstrated that sensory hypersensitivity mediated 67% of the relationship between symptoms of specific phobia and I/S and 57% of the relationship between separation anxiety and I/S...
May 24, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28506185/the-cascading-influence-of-multisensory-processing-on-speech-perception-in-autism
#6
Ryan A Stevenson, Magali Segers, Busisiwe L Ncube, Karen R Black, James M Bebko, Susanne Ferber, Morgan D Barense
It has been recently theorized that atypical sensory processing in autism relates to difficulties in social communication. Through a series of tasks concurrently assessing multisensory temporal processes, multisensory integration and speech perception in 76 children with and without autism, we provide the first behavioral evidence of such a link. Temporal processing abilities in children with autism contributed to impairments in speech perception. This relationship was significantly mediated by their abilities to integrate social information across auditory and visual modalities...
May 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28487885/novel-de-novo-variant-in-ebf3-is-likely-to-impact-dna-binding-in-a-patient-with-a-neurodevelopmental-disorder-and-expanded-phenotypes-patient-report-in-silico-functional-assessment-and-review-of-published-cases
#7
Patrick R Blackburn, Sarah S Barnett, Michael T Zimmermann, Margot A Cousin, Charu Kaiwar, Filippo Pinto E Vairo, Zhiyv Niu, Matthew J Ferber, Raul A Urrutia, Duygu Selcen, Eric W Klee, Pavel N Pichurin
Pathogenic variants in EBF3 were recently described in three back-to-back publications in association with a novel neurodevelopmental disorder characterized by intellectual disability, speech delay, ataxia, and facial dysmorphisms. In this report, we describe an additional patient carrying a de novo missense variant in EBF3 (c.487C>T, p.(Arg163Trp)) that falls within a conserved residue in the zinc knuckle motif of the DNA binding domain. Without a solved structure of the DNA binding domain, we generated a homology-based atomic model and performed molecular dynamics simulations for EBF3, which predicted decreased DNA affinity for p...
May 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28467759/nucleated-red-blood-cells-as-a-marker-of-acute-and-chronic-fetal-hypoxia-in-a-rat-model
#8
Victoria K Minior, Brian Levine, Asaf Ferber, Seth Guller, Michael Y Divon
OBJECTIVE: To examine the relationship between duration of fetal hypoxia, nucleated red blood cell (NRBC) count, and fetal growth. METHODS: Pregnant rats were exposed to a severe hypoxia (9.5%-10% O2) for varying time intervals (2, 6, 12, 24, 48, and 120 hours; n=4 for each time interval) immediately prior to delivery at term. Normoxic controls were exposed to room air (21% O2) and matched for all other study variables (n=4 rats for each time interval). Pups were delivered via hysterotomy while maintaining exposure gas concentrations...
April 28, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/28368653/lepton-flavor-dependent-angular-analysis-of-b%C3%A2-k-%C3%A2-%C3%A2
#9
S Wehle, C Niebuhr, S Yashchenko, I Adachi, H Aihara, S Al Said, D M Asner, V Aulchenko, T Aushev, R Ayad, T Aziz, V Babu, A M Bakich, V Bansal, E Barberio, W Bartel, P Behera, B Bhuyan, J Biswal, A Bobrov, A Bondar, G Bonvicini, A Bozek, M Bračko, T E Browder, D Červenkov, P Chang, V Chekelian, A Chen, B G Cheon, K Chilikin, R Chistov, K Cho, Y Choi, D Cinabro, N Dash, J Dingfelder, Z Doležal, Z Drásal, D Dutta, S Eidelman, D Epifanov, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, R Gillard, P Goldenzweig, B Golob, O Grzymkowska, E Guido, J Haba, T Hara, K Hayasaka, H Hayashii, M T Hedges, W-S Hou, C-L Hsu, T Iijima, K Inami, G Inguglia, A Ishikawa, R Itoh, Y Iwasaki, W W Jacobs, I Jaegle, H B Jeon, Y Jin, D Joffe, K K Joo, T Julius, A B Kaliyar, K H Kang, G Karyan, P Katrenko, T Kawasaki, H Kichimi, C Kiesling, D Y Kim, H J Kim, J B Kim, K T Kim, M J Kim, S H Kim, K Kinoshita, L Koch, P Kodyš, S Korpar, D Kotchetkov, P Križan, P Krokovny, T Kuhr, R Kulasiri, T Kumita, A Kuzmin, Y-J Kwon, J S Lange, C H Li, L Li, Y Li, L Li Gioi, J Libby, D Liventsev, M Lubej, T Luo, M Masuda, T Matsuda, K Miyabayashi, H Miyake, R Mizuk, G B Mohanty, T Mori, R Mussa, E Nakano, M Nakao, T Nanut, K J Nath, Z Natkaniec, M Nayak, N K Nisar, S Nishida, S Ogawa, H Ono, Y Onuki, G Pakhlova, B Pal, C-S Park, C W Park, H Park, S Paul, L Pesántez, L E Piilonen, C Pulvermacher, J Rauch, M Ritter, A Rostomyan, Y Sakai, S Sandilya, L Santelj, T Sanuki, Y Sato, V Savinov, T Schlüter, O Schneider, G Schnell, C Schwanda, A J Schwartz, Y Seino, K Senyo, O Seon, I S Seong, M E Sevior, C P Shen, T-A Shibata, J-G Shiu, B Shwartz, F Simon, R Sinha, E Solovieva, M Starič, J F Strube, K Sumisawa, T Sumiyoshi, M Takizawa, U Tamponi, F Tenchini, K Trabelsi, T Tsuboyama, M Uchida, T Uglov, Y Unno, S Uno, P Urquijo, Y Ushiroda, Y Usov, S E Vahsen, C Van Hulse, G Varner, K E Varvell, V Vorobyev, A Vossen, E Waheed, C H Wang, M-Z Wang, P Wang, M Watanabe, Y Watanabe, E Widmann, K M Williams, E Won, H Yamamoto, Y Yamashita, H Ye, Y Yook, C Z Yuan, Y Yusa, Z P Zhang, V Zhilich, V Zhukova, V Zhulanov, M Ziegler, A Zupanc
We present a measurement of angular observables and a test of lepton flavor universality in the B→K^{*}ℓ^{+}ℓ^{-} decay, where ℓ is either e or μ. The analysis is performed on a data sample corresponding to an integrated luminosity of 711  fb^{-1} containing 772×10^{6} BB[over ¯] pairs, collected at the ϒ(4S) resonance with the Belle detector at the asymmetric-energy e^{+}e^{-} collider KEKB. The result is consistent with standard model (SM) expectations, where the largest discrepancy from a SM prediction is observed in the muon modes with a local significance of 2...
March 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28339177/multisensory-speech-perception-in-autism-spectrum-disorder-from-phoneme-to-whole-word-perception
#10
Ryan A Stevenson, Sarah H Baum, Magali Segers, Susanne Ferber, Morgan D Barense, Mark T Wallace
Speech perception in noisy environments is boosted when a listener can see the speaker's mouth and integrate the auditory and visual speech information. Autistic children have a diminished capacity to integrate sensory information across modalities, which contributes to core symptoms of autism, such as impairments in social communication. We investigated the abilities of autistic and typically-developing (TD) children to integrate auditory and visual speech stimuli in various signal-to-noise ratios (SNR). Measurements of both whole-word and phoneme recognition were recorded...
March 24, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28317127/two-pathways-to-self-forgiveness-a-hedonic-path-via-self-compassion-and-a-eudaimonic-path-via-the-reaffirmation-of-violated-values
#11
Lydia Woodyatt, Michael Wenzel, Matthew Ferber
Self-forgiveness is often measured as a hedonic end-state, as the presence of positive affect and the absence of negative affect towards the self following a wrongdoing. However, self-forgiveness is also referred to as a difficult process. Self-forgiveness as a process of accepting responsibility and working through one's wrongdoing is a substantially un-hedonic - it is likely to be uncomfortable and at times painful. In this study, we examine two pathways to self-forgiveness: a hedonic focused pathway (via self-compassion) and a eudaimonic pathway (via reaffirmation of transgressed values)...
March 20, 2017: British Journal of Social Psychology
https://www.readbyqxmd.com/read/28303754/effects-of-running-experience-on-coordination-and-its-variability-in-runners
#12
Pablo Floría, Alberto Sánchez-Sixto, Reed Ferber, Andrew J Harrison
The purpose of this study was to examine the differences in coordination variability in running gait between trained runners and non-runners using continuous relative phase (CRP) analysis. Lower extremity kinematic data were collected for 22 participants during the stance phase. The participants were assigned to either a runner or non-runner group based on running volume training. Segment coordination and coordination variability were calculated for selected hip-knee and knee-ankle couplings. Independent t-tests and magnitude-based inferences were used to compare the 2 groups...
March 17, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28277107/gender-age-and-time-dependent-dosing-of-growth-hormone-in-adults-real-world-data-from-a-decade-of-clinical-practice-in-germany
#13
Peter H Kann, Simona Bergmann, Günter K Stalla, Christina Dimopoulou, Matthias M Weber, Birgitte T Pedersen, Stefanie Meckes-Ferber
We evaluated treatment patterns and gender-dependent dosing of growth hormone (GH) substitution in adults with GH deficiency (AGHD). Data on GH dose were collected (2003-2013) from 509 GH-treated patients (mean age: 48.9 years; 47% female) enroled in the observational German NordiWin study (NCT01543880). The impact of gender, age, treatment duration and calendar year on GH treatment patterns was evaluated by multiple regression analysis. Mean (SD) baseline GH dose (mg/day) was similar between females (0...
March 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28253053/kinematic-gait-patterns-in-competitive-and-recreational-runners
#14
Christian A Clermont, Sean T Osis, Angkoon Phinyomark, Reed Ferber
Certain homogeneous running subgroups demonstrate distinct kinematic patterns in running; however, the running mechanics of competitive and recreational runners are not well understood. Therefore, the purpose of this study was to determine whether we could separate and classify competitive and recreational runners according to gait kinematics using multivariate analyses and a machine learning approach. Participants were allocated to the 'competitive' (n=20) or 'recreational' group (n=15) based on age, gender, and recent race performance...
March 2, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28211706/observation-of-d-0-%C3%A2-%C3%AF-0-%C3%AE-and-search-for-cp-violation-in-radiative-charm-decays
#15
T Nanut, A Zupanc, I Adachi, H Aihara, S Al Said, D M Asner, V Aulchenko, T Aushev, R Ayad, V Babu, I Badhrees, A M Bakich, V Bansal, P Behera, V Bhardwaj, J Biswal, A Bondar, A Bozek, M Bračko, T E Browder, D Červenkov, V Chekelian, A Chen, B G Cheon, R Chistov, K Cho, S-K Choi, Y Choi, D Cinabro, N Dash, S Di Carlo, Z Doležal, D Dutta, S Eidelman, H Farhat, J E Fast, T Ferber, B G Fulsom, V Gaur, N Gabyshev, A Garmash, R Gillard, P Goldenzweig, B Golob, K Hayasaka, H Hayashii, W-S Hou, T Iijima, K Inami, G Inguglia, A Ishikawa, Y Iwasaki, W W Jacobs, I Jaegle, D Joffe, K K Joo, T Julius, A B Kaliyar, K H Kang, T Kawasaki, D Y Kim, J B Kim, K T Kim, M J Kim, S H Kim, K Kinoshita, P Kodyš, S Korpar, P Krokovny, T Kuhr, R Kulasiri, A Kuzmin, Y-J Kwon, J S Lange, I S Lee, C H Li, L Li, Y Li, L Li Gioi, J Libby, D Liventsev, M Lubej, M Masuda, T Matsuda, D Matvienko, K Miyabayashi, H Miyata, R Mizuk, G B Mohanty, H K Moon, M Nakao, K J Nath, M Nayak, N K Nisar, S Nishida, S Ogawa, S Okuno, P Pakhlov, G Pakhlova, B Pal, C-S Park, C W Park, H Park, S Paul, T K Pedlar, L Pesántez, R Pestotnik, M Petrič, L E Piilonen, K Prasanth, C Pulvermacher, J Rauch, M Ritter, A Rostomyan, Y Sakai, S Sandilya, L Santelj, T Sanuki, Y Sato, V Savinov, T Schlüter, O Schneider, G Schnell, C Schwanda, A J Schwartz, Y Seino, K Senyo, O Seon, M E Sevior, V Shebalin, C P Shen, T-A Shibata, J-G Shiu, B Shwartz, E Solovieva, S Stanič, M Starič, J F Strube, J Stypula, T Sumiyoshi, M Takizawa, U Tamponi, F Tenchini, K Trabelsi, M Uchida, S Uno, Y Ushiroda, G Varner, A Vinokurova, V Vorobyev, A Vossen, C H Wang, M-Z Wang, P Wang, Y Watanabe, E Widmann, E Won, J Yamaoka, Y Yamashita, J Yelton, Z P Zhang, V Zhilich, V Zhukova, V Zhulanov
We report the first observation of the radiative charm decay D^{0}→ρ^{0}γ and the first search for CP violation in decays D^{0}→ρ^{0}γ, ϕγ, and K[over ¯]^{*0}(892)γ, using a data sample of 943  fb^{-1} collected with the Belle detector at the KEKB asymmetric-energy e^{+}e^{-} collider. The branching fraction is measured to be B(D^{0}→ρ^{0}γ)=(1.77±0.30±0.07)×10^{-5}, where the first uncertainty is statistical and the second is systematic. The obtained CP asymmetries A_{CP}(D^{0}→ρ^{0}γ)=+0...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28196094/innate-immunity-mediated-longevity-and-longevity-induced-by-germ-cell-removal-converge-on-the-c-type-lectin-domain-protein-irg-7
#16
Elad Yunger, Modi Safra, Mor Levi-Ferber, Anat Haviv-Chesner, Sivan Henis-Korenblit
In C. elegans, removal of the germline triggers molecular events in the neighboring intestine, which sends an anti-aging signal to the rest of the animal. In this study, we identified an innate immunity related gene, named irg-7, as a novel mediator of longevity in germlineless animals. We consider irg-7 to be an integral downstream component of the germline longevity pathway because its expression increases upon germ cell removal and its depletion interferes with the activation of the longevity-promoting transcription factors DAF-16 and DAF-12 in germlineless animals...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28077442/miniaturized-nanopore-dna-sequencing-accelerating-the-path-to-precision-medicine
#17
Linnea M Baudhuin, Matthew J Ferber
No abstract text is available yet for this article.
January 11, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/27904794/pain-function-and-strength-outcomes-for-males-and-females-with-patellofemoral-pain-who-participate-in-either-a-hip-core-or-knee-based-rehabilitation-program
#18
Lori A Bolgla, Jennifer Earl-Boehm, Carolyn Emery, Karrie Hamstra-Wright, Reed Ferber
BACKGROUND: Hip exercise has been recommended for females with patellofemoral pain (PFP). It is unknown if males with PFP will benefit from a similar treatment strategy. HYPOTHESES/PURPOSE: The purpose of this study was to compare improvements in pain, function, and strength between males and females with PFP who participated in either a hip/core or knee rehabilitation program. The directional hypothesis was that females would respond more favorably to the hip/core rehabilitation program and males to the knee program...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27889189/reliability-of-gait-analysis-using-wearable-sensors-in-patients-with-knee-osteoarthritis
#19
Dylan Kobsar, Sean T Osis, Angkoon Phinyomark, Jeffrey E Boyd, Reed Ferber
The aim of this study was to determine the test-retest reliability of linear acceleration waveforms collected at the low back, thigh, shank, and foot during walking, in a cohort of knee osteoarthritis patients, by applying two separate sensor attitude correction methods (static attitude correction and dynamic attitude correction). Linear acceleration data were collected on the subjects׳ most affected limb during treadmill walking on two separate days. Results reveal all attitude corrected acceleration waveforms displayed high repeatability, with coefficient of multiple determination values ranging from 0...
December 8, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27872236/preclinical-and-early-clinical-profile-of-a-highly-selective-and-potent-oral-inhibitor-of-aldosterone-synthase-cyp11b2
#20
Katrijn Bogman, Dietmar Schwab, Marie-Laure Delporte, Giuseppe Palermo, Kurt Amrein, Susanne Mohr, Maria Cristina De Vera Mudry, Morris J Brown, Philippe Ferber
Primary hyperaldosteronism is a common cause of resistant hypertension. Aldosterone is produced in the adrenal by aldosterone synthase (AS, encoded by the gene CYP11B2). AS shares 93% homology to 11β-hydroxylase (encoded by the gene CYP11B1), responsible for cortisol production. This homology has hitherto impeded the development of a drug, which selectively suppresses aldosterone but not cortisol production, as a new treatment for primary hyperaldosteronism. We now report the development of RO6836191 as a potent (Ki 13 nmol/L) competitive inhibitor of AS, with in vitro selectivity >100-fold over 11β-hydroxylase...
January 2017: Hypertension
keyword
keyword
34042
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"