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https://www.readbyqxmd.com/read/29679061/the-role-of-macrophage-migration-inhibitory-factor-in-the-function-of-intestinal-barrier
#1
Milica Vujicic, Tamara Saksida, Sanja Despotovic, Svetlana Sokovic Bajic, Ivana Lalić, Ivan Koprivica, Dragica Gajic, Natasa Golic, Maja Tolinacki, Ivana Stojanovic
Macrophage migration inhibitory factor (MIF) is a multifunctional protein that is involved in the development of gut-related inflammation. To investigate the role of MIF in the function of the intestinal barrier, we have explored intestinal permeability and gut-associated immune response in MIF-deficient (MIF-KO) mice. The absence of MIF provoked impairment of tight and adherens epithelial junctions in the colon through the disturbance of E-cadherin, zonula occludens-1, occludin and claudin-2 expression, which lead to the increase of intestinal barrier permeability...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678231/incorporation-of-membrane-anchored-flagellin-into-salmonella-gallinarum-bacterial-ghosts-induces-early-immune-responses-and-protection-against-fowl-typhoid-in-young-layer-chickens
#2
Irshad Ahmed Hajam, Je Hyoung Kim, John Hwa Lee
The present study aimed to investigate whether the incorporation of flagellin, a TLR5 agonist, in the bacterial ghosts (BGs) of Salmonella Gallinarum can enhance protective immune responses against fowl typhoid, a septicemic disease of poultry, in chickens. BGs are empty cell envelopes derived from Gram-negative bacteria through the bacteriophage phiX174 gene E mediated lysis. In this study, the S. Gallinarum ghosts carrying flagellin were genetically constructed utilizing a lysis plasmid pJHL184-flagellin, designed for the coexpression of the flagellin and the lysis protein E...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29677101/electromyographic-and-joint-kinematic-patterns-in-runner-s-dystonia
#3
Omar F Ahmad, Pritha Ghosh, Christopher Stanley, Barbara Karp, Mark Hallett, Codrin Lungu, Katharine Alter
Runner’s dystonia (RD) is a task-specific focal dystonia of the lower limbs that occurs when running. In this retrospective case series, we present surface electromyography (EMG) and joint kinematic data from thirteen patients with RD who underwent instrumented gait analysis (IGA) at the Functional and Biomechanics Laboratory at the National Institutes of Health. Four cases of RD are described in greater detail to demonstrate the potential utility of EMG with kinematic studies to identify dystonic muscle groups in RD...
April 20, 2018: Toxins
https://www.readbyqxmd.com/read/29672552/induction-of-salivary-antibody-levels-in-dutch-adolescents-after-immunization-with-monovalent-meningococcal-serogroup-c-or-quadrivalent-meningococcal-serogroup-a-c-w-and-y-conjugate-vaccine
#4
Mariëtte B van Ravenhorst, Gerco den Hartog, Fiona R M van der Klis, Debbie M van Rooijen, Elisabeth A M Sanders, Guy A M Berbers
BACKGROUND: Meningococcal infection starts with colonisation of the upper respiratory tract. Mucosal immunity is important for protection against acquisition and subsequent meningococcal carriage. In this study, we assessed salivary antibody levels against meningococcal serogroup A (MenA), W (MenW) and Y (MenY) after vaccination with a quadrivalent MenACWY conjugated vaccine. We also compared salivary meningococcal serogroup C (MenC) antibody levels after monovalent MenC and quadrivalent MenACWY conjugated vaccination...
2018: PloS One
https://www.readbyqxmd.com/read/29672364/role-of-direct-immunofluorescence-in-cutaneous-small-vessel-vasculitis-experience-from-a-tertiary-center
#5
Khushboo Lath, Debajyoti Chatterjee, Uma Nahar Saikia, Biman Saikia, Ranjana Minz, Dipankar De, Sanjeev Handa, Bishan Radotra
Skin is commonly affected by vasculitic process and often subjected to biopsy. Cutaneous vasculitis can be either primary or part of a systemic vasculitic process. This study was conducted to evaluate the diagnostic utility of direct immunofluorescence (DIF) in determination of etiology of cutaneous vasculitis. All histologically proven cases of cutaneous vasculitis over the past two and half years were retrospectively analyzed along with their clinical and DIF findings (IgG, IgA, IgM, and C3). Within this study period, a total of 198 cases of small-vessel vasculitis were diagnosed based on skin biopsy and DIF findings...
April 17, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29671919/a-conserved-rxlr-effector-interacts-with-host-raba-type-gtpases-to-inhibit-vesicle-mediated-secretion-of-antimicrobial-proteins
#6
Iga Tomczynska, Michael Stumpe, Felix Mauch
Plant pathogens of the oomycete genus Phytophthora produce virulence factors, known as RxLR effector proteins that are transferred into host cells to suppress disease resistance. Here, we analyse the function of the highly conserved RxLR24 effector of Phytophthora brassicae. RxLR24 was expressed early in the interaction with Arabidopsis plants and ectopic expression in the host enhanced leaf colonization and zoosporangia formation. Co-immunoprecipitation experiments followed by mass spectrometry identified different members of the RABA GTPase family as putative RxLR24 targets...
April 19, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29671115/utility-of-dna-rna-protein-and-functional-approaches-to-solve-cryptic-immunodeficiencies
#7
Margot A Cousin, Matthew J Smith, Ashley N Sigafoos, Jay J Jin, Marine I Murphree, Nicole J Boczek, Patrick R Blackburn, Gavin R Oliver, Ross A Aleff, Karl J Clark, Eric D Wieben, Avni Y Joshi, Pavel N Pichurin, Roshini S Abraham, Eric W Klee
PURPOSE: We report a female infant identified by newborn screening for severe combined immunodeficiencies (NBS SCID) with T cell lymphopenia (TCL). The patient had persistently elevated alpha-fetoprotein (AFP) with IgA deficiency, and elevated IgM. Gene sequencing for a SCID panel was uninformative. We sought to determine the cause of the immunodeficiency in this infant. METHODS: We performed whole-exome sequencing (WES) on the patient and parents to identify a genetic diagnosis...
April 18, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29670778/multiple-arterial-thrombosis-related-with-cantharidin-ingestion
#8
Zehra Narli Ozdemir, Ugur Sahin, Sinem Civriz Bozdag, Osman Ilhan
Inherited and/or acquired thrombophilic defects can result in venous or arterial thrombosis. This case report describes arterial thrombotic episodes triggered by the ingestion of an aphrodisiac remedy containing cantharidin in a 46-year-old female patient later discovered to be heterozygous for prothrombin G20210A mutation and seropositive for anti- β 2 glycoprotein-I (anti- β 2-GPI) antibodies of IgA isotype.
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29670718/evaluating-the-relationship-between-dental-caries-number-and-salivary-level-of-iga-in-adults
#9
Hesam Haeri-Araghi, Mahdieh Zarabadipour, Shadab Safarzadeh-Khosroshahi, Monirsadat Mirzadeh
Background: Dental caries are the most common mouth infectious disease and also chronic disease of childhood. Saliva plays different roles in oral cavity; for example, salivary immunoglobulins play significant role in body and oral immunity. Various studies were conducted on the different effects of IgA on oral cavity, especially dental caries, and reported controversial results. The current study aimed to compare salivary IgA level at different stages of dental caries in adults. Material and Methods: A total of 40 adults, aged 20 to 40 years, referred to the department of oral medicine at Qazvin Faculty of Dentistry, were selected voluntarily based on the number of decayed teeth...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29670408/acute-hepatitis-e-in-a-renal-transplantation-recipient-a-case-report
#10
Mitsutoshi Shindo, Hiroaki Takemae, Takafumi Kubo, Masatsugu Soeno, Tetsuo Ando, Yoshiyuki Morishita
Hepatitis E is caused by infection with the hepatitis E virus (HEV). HEV is transmitted orally via HEV-contaminated food or drink. Hepatitis E usually shows mild symptoms and is self-limiting in the general population; however, it may progress to chronic hepatitis in immunosuppressed patients such as recipients of organ transplantation. However, a few cases of acute hepatitis E have been reported in organ transplantation recipients. We herein report a case of acute hepatitis E in a 31-year-old male renal transplant recipient...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29669399/the-impact-of-systemic-lupus-erythematosus-on-the-clinical-phenotype-of-antiphospholipid-antibody-positive-patients-results-from-antiphospholipid-syndrome-alliance-for-clinical-trials-and-international-networking-aps-action-clinical-database-and-repository
#11
Ozan Unlu, Doruk Erkan, Medha Barbhaiya, Danieli Andrade, Iana Nascimento, Renata Rosa, Alessandra Banzato, Vittorio Pengo, Amaia Ugarte, Maria Gerosa, Lanlan Ji, Maria Efthymiou, D Ware Branch, Guilherme Raires de Jesus, Angela Tincani, H Michael Belmont, Paul R Fortin, Michelle Petri, Esther Rodriguez, Guillermo J Pons-Estel, Jason S Knight, Tatsuya Atsumi, Rohan Willis, Stephane Zuily, Maria G Tektonidou
OBJECTIVE: Although systemic lupus erythematosus (SLE) is the most common autoimmune disease associated with antiphospholipid antibodies (aPL), limited data exist on the impact of SLE on the clinical phenotype of aPL-positive patients. The primary objective was to compare the clinical, laboratory, and treatment characteristics of aPL-positive patients with or without SLE. METHODS: A secure web-based data capture system stores patient demographics, and aPL-related clinical and laboratory characteristics...
April 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29668624/effect-of-%C3%AF-3-polyunsaturated-fatty-acid-supplemented-parenteral-nutrition-on-inflammatory-and-immune-function-in-postoperative-patients-with-gastrointestinal-malignancy-a-meta-analysis-of-randomized-control-trials-in-china
#12
Yajie Zhao, Chengfeng Wang
BACKGROUND: There are no consensus regarding the efficacy of omega-3polyunsaturated fatty acids (PUFAs) on inflammatory and immune function in postoperative patients with gastrointestinal malignancy. METHODS: The literatures published randomized control trials (RCT) were searched in PubMed, Embase, Scopus, Cochrane Library, CNKI, Weipu, and Wanfang Databases. The immune efficacy outcomes of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition in patients with gastrointestinal malignancy were compared...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667858/longitudinal-analysis-of-varicella-zoster-virus-specific-antibodies-in-systemic-lupus-erythematosus-no-association-with-subclinical-viral-reactivations-or-lupus-disease-activity
#13
C Rondaan, C C van Leer, S van Assen, H Bootsma, K de Leeuw, S Arends, N A Bos, J Westra
Systemic lupus erythematosus (SLE) patients are at high risk of herpes zoster. Previously, we found increased immunoglobulin (Ig)G levels against varicella-zoster virus (VZV) in SLE patients compared to controls, while antibody levels against diphtheria and cellular immunity to VZV were decreased. We aimed to test our hypothesis that increased VZV-IgG levels in SLE result from subclinical VZV reactivations, caused by stress because of lupus disease activity or immunosuppressive drug use. Methods Antibody levels to VZV (IgG, IgA, IgM), total IgG and VZV-DNA were longitudinally determined in the serum of 34 SLE patients, using enzyme-linked immunosorbent assay and polymerase chain reaction...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29667608/linear-iga-bullous-dermatosis-induced-by-diclofenac-sodium
#14
Sarita Sanke, Abhinav Kumar, Ram Chander
No abstract text is available yet for this article.
April 12, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29664567/memory-control-by-the-b-cell-antigen-receptor
#15
REVIEW
Niklas Engels, Jürgen Wienands
The generation of memory B cells (MBCs) that have undergone immunoglobulin class switching from IgM, which dominates primary antibody responses, to other immunoglobulin isoforms is a hallmark of immune memory. Hence, humoral immunological memory is characterized by the presence of serum immunoglobulins of IgG subtypes known as the γ-globulin fraction of blood plasma proteins. These antibodies reflect the antigen experience of B lymphocytes and their repeated triggering. In fact, efficient protection against a previously encountered pathogen is critically linked to the production of pathogen-specific IgG molecules even in those cases where the primary immune response required cellular immunity, for example, T cell-mediated clearance of intracellular pathogens such as viruses...
May 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29664511/bullous-henoch-sch%C3%A3-nlein-purpura-case-report
#16
Trinidad Hasbún, Ximena Chaparro, Viera Kaplan, Felipe Cavagnaro, Alex Castro
Henoch-Schönlein purpura (HSP) or IgA Vasculitis is the most common childhood vasculitis. The classic tetrad of signs and symptoms include palpable purpura, arthralgia, abdominal pain and renal disease. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. Objec tive: To report an unusual cutaneous manifestation of HSP in children. CASE REPORT: A 14-year-old girl complained about a 2-week painful bullous rash in both lower extremities and multiple arthral gias...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29662874/prevalent-emm-types-among-invasive-gas-in-europe-and-north-america-since-year-2000
#17
Giovanni Gherardi, Luca Agostino Vitali, Roberta Creti
Background: Streptococcus pyogenes or group A streptococcus (GAS) is an important human pathogen responsible for a broad range of infections, from uncomplicated to more severe and invasive diseases with high mortality and morbidity. Epidemiological surveillance has been crucial to detect changes in the geographical and temporal variation of the disease pattern; for this purpose the M protein gene ( emm) gene typing is the most widely used genotyping method, with more than 200 emm types recognized...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29661452/staphylococcus-infection-associated-glomerulonephritis-in-a-kidney-transplant-patient-case-report
#18
D Cascais de Sá, L Rodrigues, L Santos, C Romãozinho, F Macário, C Marinho, J Pratas, R Alves, A Figueiredo
BACKGROUND: Staphylococcus infection-associated glomerulonephritis is a rare cause of graft dysfunction in kidney transplant. Suspicion should be high in the setting of elevation of serum creatinine, active urinary sediment, with or without hypocomplementemia, and simultaneous Staphylococcus aureus infection. A kidney biopsy is usually diagnostic. CASE REPORT: A 56-year-old man, who received a kidney transplant in 1998, with basal serum creatinine of 1.2 mg/dL and normal urinary sediment, was admitted to our kidney transplantation unit with graft dysfunction and a urinary tract infection caused by S aureus with septicemia, treated with antibiotics, in the context of recently intensified immunosuppression for a primary immune thrombocytopenia diagnosed 3 weeks earlier...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29660832/first-year-gfr-slope-and-long-term-renal-outcome-in-iga-nephropathy
#19
Kyungho Lee, Jung-Ho Shin, Jeeeun Park, Subin Hwang, Hye Ryoun Jang, Wooseong Huh, Ghee Young Kwon, Yoon-Goo Kim, Ha Young Oh, Jung Eun Lee, Dae Joong Kim
BACKGROUND: IgA nephropathy (IgAN) is the most frequent primary glomerular disease and the leading cause of end-stage renal disease. We investigated clinicopathologic predictors of renal survival in patients with IgAN with a focus on glomerular filtration rate (GFR) decline slope. MATERIALS AND METHODS: We screened all patients with primary IgAN between 1995 and 2012. Renal progression was defined as doubling of serum creatinine. Using serial serum creatinine levels during the first-year, we calculated the GFR decline slopes...
April 16, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29660095/effect-of-dietary-bacillus-coagulans-supplementation-on-growth-performance-and-immune-responses-of-broiler-chickens-challenged-by-salmonella-enteritidis
#20
Wenrui Zhen, Yujing Shao, Xiuyan Gong, Yuanyuan Wu, Yanqiang Geng, Zhong Wang, Yuming Guo
This study was conducted to evaluate the protective efficacy of dietary Bacillus coagulans (B. coagulans) supplementation in birds receiving Salmonella enteritidis (SE). Two hundred and forty 1-day-old Cobb broilers were randomly assigned to 2 × 2 factorial arrangements of treatments with 2 levels of dietary B. coagulans (0 or 400 mg/kg) and 2 levels of SE challenge (0 or 1 × 109 SE between d 9 to 11). Results showed that SE infection did not affect growth performance, but caused intestinal inflammation and barrier function impairment by reducing intestinal goblet cells and beneficial bacteria numbers, increasing cecal Salmonella colonization and liver Salmonella invasion, downregulating jejunal mucin-2 (at 7 and 17 d post-infection, DPI), TLR2 (at 7 and 17 DPI), TLR4 (at 17 DPI), TNFSF15 (at 7 and 17 DPI) gene mRNA levels, and upregulating jejunal IFN-γ mRNA levels (at 17 DPI) compared to uninfected birds...
April 11, 2018: Poultry Science
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