Corina Cheng Ai Ding, Socrates Dokos, Azam Ahmad Bakir, Nurul Jannah Zamberi, Yih Miin Liew, Bee Ting Chan, Nor Ashikin Md Sari, Alberto Avolio, Einly Lim
Aortic stenosis, hypertension, and left ventricular hypertrophy often coexist in the elderly, causing a detrimental mismatch in coupling between the heart and vasculature known as ventricular-vascular (VA) coupling. Impaired left VA coupling, a critical aspect of cardiovascular dysfunction in aging and disease, poses significant challenges for optimal cardiovascular performance. This systematic review aims to assess the impact of simulating and studying this coupling through computational models. By conducting a comprehensive analysis of 34 relevant articles obtained from esteemed databases such as Web of Science, Scopus, and PubMed until July 14, 2022, we explore various modeling techniques and simulation approaches employed to unravel the complex mechanisms underlying this impairment...
February 22, 2024: Biomedical Engineering Online