keyword
https://read.qxmd.com/read/38534740/covid-19-associated-cardiovascular-disease-risks-prevention-and-management-heart-at-risk-due-to-covid-19
#21
REVIEW
Andrew Kemerley, Abhishek Gupta, Mahesh Thirunavukkarasu, Monica Maloney, Sean Burgwardt, Nilanjana Maulik
The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and the resulting COVID-19 pandemic have had devastating and lasting impact on the global population. Although the main target of the disease is the respiratory tract, clinical outcomes, and research have also shown significant effects of infection on other organ systems. Of interest in this review is the effect of the virus on the cardiovascular system. Complications, including hyperinflammatory syndrome, myocarditis, and cardiac failure, have been documented in the context of COVID-19 infection...
February 29, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534342/a-recombinant-peptide-device-combined-with-adipose-tissue-derived-stem-cells-enhances-subcutaneous-islet-engraftment
#22
JOURNAL ARTICLE
Takahiro Mizui, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Satomi Suzuki Uematsu, Shigehito Miyagi, Takashi Kamei, Michiaki Unno, Kimiko Watanabe, Masafumi Goto
Subcutaneous space has been considered an attractive site for islet graft transplantation; however, the oxygen tension and vascularization are insufficient for islet graft survival. We investigated whether subcutaneous pre-implantation of a recombinant peptide (RCP) device with adipose tissue-derived stem cells (ADSCs) enhanced subcutaneous islet engraftment. RCP devices with/without syngeneic ADSCs were pre-implanted into the subcutaneous space of C57BL/6 mice. Syngeneic islets (300 or 120 islet equivalents (IEQs)) were transplanted into the pre-treated space after diabetes induction using streptozotocin...
March 13, 2024: Cells
https://read.qxmd.com/read/38534112/accelerating-therapeutics-development-during-a-pandemic-population-pharmacokinetics-of-the-long-acting-antibody-combination-azd7442-tixagevimab-cilgavimab-in-the-prophylaxis-and-treatment-of-covid-19
#23
JOURNAL ARTICLE
Lindsay E Clegg, Oleg Stepanov, Henning Schmidt, Weifeng Tang, Huixia Zhang, Chris Webber, Taylor S Cohen, Mark T Esser, Mats Någård
AZD7442 is a combination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing antibodies, tixagevimab and cilgavimab, developed for pre-exposure prophylaxis (PrEP) and treatment of coronavirus disease 2019 (COVID-19). Using data from eight clinical trials, we describe a population pharmacokinetic (popPK) model of AZD7442 and show how modeling of "interim" data accelerated decision-making during the COVID-19 pandemic. The final model was a two-compartmental distribution model with first-order absorption and elimination, including standard allometric exponents for the effect of body weight on clearance and volume...
March 27, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38533846/longitudinal-management-of-cardiovascular-risk-factors-among-postpartum-women
#24
JOURNAL ARTICLE
Rebecca Lumsden, Courtney B Page, Matthew Phelan, Sarahn Wheeler, Neha Pagidipati
Background: Pregnancy-related cardiovascular (CV) conditions, including hypertensive disorders of pregnancy (HDP) and gestational diabetes (GDM), are associated with increased long-term CV risk. Methods: This retrospective cohort study defined the prevalence of HDP and GDM within a large, academic health system in the southeast United States between 2012 and 2015 and described health care utilization and routine CV screening up to 1-year following delivery among those with pregnancy-related CV conditions. Rates of follow-up visits and blood pressure, hemoglobin A1c (HbA1c), and lipid screening in the first postpartum year were compared by provider type and pregnancy-related CV condition...
March 27, 2024: Journal of Women's Health
https://read.qxmd.com/read/38533515/tigit-acts-as-an-immune-checkpoint-upon-inhibition-of-pd1-signaling-in-autoimmune-diabetes
#25
JOURNAL ARTICLE
Prerak Trivedi, Gaurang Jhala, David J De George, Chris Chiu, Claudia Selck, Tingting Ge, Tara Catterall, Lorraine Elkerbout, Louis Boon, Nicole Joller, Thomas W Kay, Helen E Thomas, Balasubramanian Krishnamurthy
INTRODUCTION: Chronic activation of self-reactive T cells with beta cell antigens results in the upregulation of immune checkpoint molecules that keep self-reactive T cells under control and delay beta cell destruction in autoimmune diabetes. Inhibiting PD1/PD-L1 signaling results in autoimmune diabetes in mice and humans with pre-existing autoimmunity against beta cells. However, it is not known if other immune checkpoint molecules, such as TIGIT, can also negatively regulate self-reactive T cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533301/impact-and-prevalence-of-comorbidities-and-complications-on-the-severity-of-covid-19-in-association-with-age-gender-obesity-and-pre-existing-smoking-a-meta-analysis
#26
REVIEW
Soulandi Djorwé, Amale Bousfiha, Néhémie Nzoyikorera, Joseph Nyandwi, Bellamine Kawthar, Abderrahim Malki
BACKGROUND: COVID-19 patients usually present multiple comorbidities and complications associated with severe forms of SARS-CoV-2 infection. This study aimed to assess the risk factors and prevalence of comorbidities and complications contributing to the severity of COVID-19. METHODS: This meta-analysis was performed according to PRISMA guidelines. We searched various databases, including PubMed, Google Scholar, and Scopus (between 2020 and 2023), for eligible studies for this meta-analysis...
2024: BioMedicine
https://read.qxmd.com/read/38533281/efficacy-of-pistacia-lentiscus-plant-rumi-mastagi-in-comparison-to-levosulpiride-in-patients-with-diabetic-gastroparesis-a-double-blind-non-inferior-randomised-control-trial-study
#27
JOURNAL ARTICLE
Ajaypal Singh, Ravi Kant, Rohit Raina, Vandana Dhingra, Rajeev Nema, Mukesh Chand Bairwa, Varsha Kanwar, Rifika L Sukhes Mukherjee, Anissa Atif Mirza, Mayank Agarwal
INTRODUCTION: Gastrointestinal neuropathies are frequently found in diabetic patients. The pathogenesis of diabetic gastroparesis (DG) is multifactorial. The usual treatment for DG includes dietary modifications, prokinetic and antiemetic agents. There is increasing demand for more effective medicines to treat DG. The current study was conducted on the Pistacia lentiscus stem extract to add to the armamentarium of DG treatment and to find the efficacy of P. lentiscus plant extract (mastic gum) in comparison to levosulpiride in DG for improvement in gastroparesis symptoms and gastric emptying scintigraphy (GES) in a single centric double-blind non-inferiority randomised control trial...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533280/evaluation-of-effect-of-montelukast-in-the-model-of-streptozotocin-induced-diabetic-nephropathy-in-rats
#28
JOURNAL ARTICLE
Dhananjay Kokate, Padmaja Marathe
BACKGROUND: Diabetic nephropathy is a progressive condition and a leading cause of end-stage renal disease. Oxidative stress and inflammation play an important role in its pathogenesis. In pre-clinical studies, Montelukast had shown renoprotective and anti-oxidant properties, hence the study was planned to evaluate the effect of Montelukast in a Streptozotocin (STZ) induced model of diabetic nephropathy. METHODS: 40 Wistar rats of either sex were randomly divided into four groups viz ...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532824/association-of-bmi-and-incidence-of-type-2-diabetes-in-saudi-population
#29
JOURNAL ARTICLE
Qasem AlJabr, Mohammed Alalawi, Baqer Aldhneen, Ali Al Gharash, Mohammed Aldabbab, Habib Aldabbab, Ali Bu-Khamseen, Abdullah Alkattan, Abdullah Al Sayafi
OBJECTIVE: The study aims to identify the optimal body mass index (BMI) cut-off for obesity based on the risk of developing type 2 diabetes among the general population visiting primary health care in Saudi Arabia. METHODS: A cross-sectional study was conducted in Al-Ahsa City, Saudi Arabia, from January to June 2022. The study included Saudi citizens aged 35 and older who had not previously or currently been diagnosed with type 2 diabetes. Data were collected through electronic health records from 48 primary healthcare centers...
March 2024: Health Science Reports
https://read.qxmd.com/read/38532128/liver-chrebp-deficiency-inhibits-fructose-induced-insulin-resistance-in-pregnant-mice-and-female-offspring
#30
JOURNAL ARTICLE
Jiaqi Li, Shuang Zhang, Yuyao Sun, Jian Li, Zian Feng, Huaxin Li, Mengxue Zhang, Tengteng Yan, Jihong Han, Yajun Duan
High fructose intake during pregnancy increases insulin resistance (IR) and gestational diabetes mellitus (GDM) risk. IR during pregnancy primarily results from elevated hormone levels. We aim to determine the role of liver carbohydrate response element binding protein (ChREBP) in insulin sensitivity and lipid metabolism in pregnant mice and their offspring. Pregnant C57BL/6J wild-type mice and hepatocyte-specific ChREBP-deficient mice were fed with a high-fructose diet (HFrD) or normal chow diet (NC) pre-delivery...
March 26, 2024: EMBO Reports
https://read.qxmd.com/read/38532020/contemporary-pharmacological-treatment-and-management-of-heart-failure
#31
REVIEW
Biykem Bozkurt
The prevention and treatment strategies for heart failure (HF) have evolved in the past two decades. The stages of HF have been redefined, with recognition of the pre-HF state, which encompasses asymptomatic patients who have developed either structural or functional cardiac abnormalities or have elevated plasma levels of natriuretic peptides or cardiac troponin. The first-line treatment of patients with HF with reduced ejection fraction includes foundational therapies with angiotensin receptor-neprilysin inhibitors, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, β-blockers, mineralocorticoid receptor antagonists, sodium-glucose cotransporter 2 (SGLT2) inhibitors and diuretics...
March 26, 2024: Nature Reviews. Cardiology
https://read.qxmd.com/read/38531573/policies-for-type-2-diabetes-and-non-communicable-disease-management-during-the-covid-19-pandemic-in-kenya-and-tanzania-a-desk-review-and-views-of-decision-makers
#32
JOURNAL ARTICLE
Shukri F Mohamed, Lyagamula Kisia, Irene Mashiashi, Frances Mair, Jennifer P Wisdom, Christopher Bunn, Cindy Gray, Peter M Kibe, Richard E Sanya, Caroline H Karugu, Sally M Mtenga, Peter Binyaruka, Gershim Asiki
BACKGROUND: The COVID-19 pandemic caused disruptions in care that adversely affected the management of non-communicable diseases (NCDs) globally. Countries have responded in various ways to support people with NCDs during the pandemic. This study aimed to identify policy gaps, if any, in the management of NCDs, particularly diabetes, during COVID-19 in Kenya and Tanzania to inform recommendations for priority actions for NCD management during any future similar crises. METHODS: We undertook a desk review of pre-existing and newly developed national frameworks, policy models and guidelines for addressing NCDs including type 2 diabetes...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531354/antibiotic-bone-cement-accelerates-diabetic-foot-wound-healing-elucidating-the-role-of-rock1-protein-expression
#33
JOURNAL ARTICLE
Chenglan Yang, Dali Wang
Clinical studies indicate antibiotic bone cement with propeller flaps improves diabetic foot wound repair and reduces amputation rates, but the molecular mechanisms, particularly key proteins' role remain largely unexplored. This study assessed the efficacy of antibiotic bone cement for treating diabetic foot wounds, focusing on molecular impact on ROCK1. Sixty patients were randomized into experimental (EXP, n = 40) and control (CON, n = 20) groups, treated with antibiotic bone cement and negative pressure...
April 2024: International Wound Journal
https://read.qxmd.com/read/38531094/syringe-assisted-test-aspiration-with-mechanical-aspiration-thrombectomy-results-in-good-safety-and-short-term-outcomes-in-the-treatment-of-patients-with-deep-venous-thrombosis
#34
JOURNAL ARTICLE
Wanglong Li, Yichen Lin, Kunfeng Su, Fanggang Cai, Jinchi Zhang, Xiaoling Lai, Xiaoqi Zheng, Pingfan Guo, Xinhuang Hou, Yiquan Dai
OBJECTIVE: To evaluate the short-term outcomes and safety of syringe-assisted test-aspiration with mechanical aspiration thrombectomy in the treatment of deep venous thrombosis. METHODS: This was a single-center, retrospective study of hospitalized patients with iliofemoral and/or inferior vena caval deep venous thrombosis, excluding those with pulmonary embolism. We collected the following patient data from the electronic medical records: age, sex, provoked/unprovoked deep venous thrombosis, symptom duration, thrombosed segments, and the presence of a tumor, thrombophilia, diabetes, and/or iliac vein compression syndrome...
March 26, 2024: Vascular
https://read.qxmd.com/read/38530242/hypertension-and-risk-of-endometrial-cancer-a-pooled-analysis-in-the-epidemiology-of-endometrial-cancer-consortium-e2c2
#35
JOURNAL ARTICLE
Talar S Habeshian, Noah C Peeri, Immaculata De Vivo, Leo J Schouten, Xiao-Ou Shu, Michele L Cote, Kimberly A Bertrand, Yu Chen, Megan A Clarke, Tess V Clendenen, Linda S Cook, Laura Costas, Luigino Dal Maso, Jo L Freudenheim, Christine M Friedenreich, Grace Gallagher, Gretchen L Gierach, Marc T Goodman, Susan J Jordan, Carlo La Vecchia, James V Lacey, Fabio Levi, Linda M Liao, Loren Lipworth, Lingeng Lu, Xavier Matías-Guiu, Kirsten B Moysich, George L Mutter, Renhua Na, Jeffin Naduparambil, Eva Negri, Kelli O'Connell, Tracy A O'Mara, Irene Onieva Hernández, Julie R Palmer, Fabio Parazzini, Alpa V Patel, Kathryn L Penney, Anna E Prizment, Fulvio Ricceri, Harvey A Risch, Carlotta Sacerdote, Sven Sandin, Rachael Z Stolzenberg-Solomon, Piet A van den Brandt, Penelope M Webb, Nicolas Wentzensen, Akemi T Wijayabahu, Lynne R Wilkens, Wanghong Xu, Herbert Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Mengmeng Du, Veronica Wendy Setiawan
BACKGROUND: The incidence rates of endometrial cancer (EC) are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for EC. Hypertension, another component of metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it may be associated with the development of certain cancers. The role of hypertension independent of other components of metabolic syndrome in the etiology of EC remains unclear. In this study we evaluated hypertension as an independent risk factor for EC and whether this association is modified by other established risk factors...
March 26, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38529589/metformin-alters-tumor-immune-microenvironment-improving-the-outcomes-of-breast-cancer-patients-with-type-2-diabetes-mellitus
#36
JOURNAL ARTICLE
Satomi Shiba, Michiko Harao, Akira Saito, Masako Sakuragi, Joji Kitayama, Naohiro Sata
This study investigated the clinical effect of metformin on breast cancer patients with preexisting type 2 diabetes mellitus (T2DM). We analyzed 177 patients with T2DM who underwent breast cancer surgery and assessed tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) in patients who underwent tumor resection with or without metformin treatment using multiplex immunohistochemistry (IHC). Patients who received metformin either pre- or postoperatively exhibited reduced distant organ recurrence and improved postoperative recurrence-free survival compared to those of patients who did not...
February 23, 2024: Journal of Breast Cancer
https://read.qxmd.com/read/38529459/preoperative-ecg-abnormalities-among-patients-who-underwent-elective-surgical-operations-at-the-kuwaiti-specialised-hospital-khartoum-sudan-a-cross-sectional-study
#37
JOURNAL ARTICLE
Sharwany S Ahmed, Tartel Ahmed, Eltayeb G Abdalla, Abubakr Ali M Humidan, Ayat Mohamed Abdalaziz Daffalla, Abdelfatah T Elgabani, Mujtaba A Abdelrahem, Tawasul Bilal, Azza A Ibrahim
BACKGROUND: The presence of preoperative ECG abnormalities has shown wide variation, and its value has been argued; thus, this study aimed to determine preoperative ECG abnormalities among Sudanese patients and their correlates. MATERIALS AND METHODS: An observational descriptive cross-sectional study was conducted at the Kuwaiti Specialised Hospital, Khartoum, Sudan, from October 2020 to March 2021, including all patients over 40 years of age who planned to undergo elective surgery...
February 2024: Curēus
https://read.qxmd.com/read/38528861/pre-pregnancy-body-mass-index-gestational-diabetes-mellitus-and-gestational-weight-gain-individual-and-combined-effects-on-fetal-growth
#38
JOURNAL ARTICLE
Yanyu Lyu, Mingming Cui, Lingling Zhang, Guang Zheng, Hanxiao Zuo, Qingyong Xiu, Prakesh S Shah
BACKGROUND: Pre-pregnancy body mass index (BMI), gestational diabetes mellitus (GDM), and gestational weight gain (GWG) are interlinked and may play a complex role in fetal growth. We aimed to examine the relationship between pre-pregnancy BMI, GDM, GWG, and fetal growth outcomes and explore the contribution of GDM and GWG to the relationship between Pre-pregnancy obesity/overweight and large-for-gestational-age (LGA) in a prospective cohort. METHODS: We prospectively recruited women in the first trimester and having one-step GDM screened with a 75-g oral glucose tolerance test between 24 and 28 weeks of gestation ( n  = 802)...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38528781/increased-symptoms-of-stiffness-after-opening-wedge-high-tibial-osteotomy-are-associated-with-worse-postoperative-knee-function-outcomes-and-lower-patient-satisfaction-rate
#39
JOURNAL ARTICLE
Jiahao Yu, Bixuan Song, Yanbin Zhu, Juan Wang, Yingze Zhang
BACKGROUND: Symptoms of knee stiffness after open wedge high tibial osteotomy (OW-HTO) can significantly affect surgical effectiveness, but no studies have reported risk factors for knee stiffness after OW-HTO. METHODS: Patients treated with OW-HTO for the first time between 2018 and 2021 were included. Data were collected on patient demographics, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Short Form (SF) 12 scores, hip-knee-ankle angle (HKA) and patient satisfaction before and after surgery...
2024: Journal of Orthopaedic Surgery
https://read.qxmd.com/read/38528508/triglyceride-glucose-index-in-early-pregnancy-predicts-the-risk-of-gestational-diabetes-a-prospective-cohort-study
#40
JOURNAL ARTICLE
Yufeng Guo, Junwen Lu, Mailiman Bahani, Guifeng Ding, Lei Wang, Yuxia Zhang, Huanmei Zhang, Chengyao Liu, Lijun Zhou, Xiaolan Liu, Fangshen Li, Xiaoli Wang, Hong Ding
OBJECTIVE: This study aimed to investigate the association between the triglyceride-glucose (TyG) index in early pregnancy and the development of gestational diabetes mellitus (GDM) in the second trimester. The primary objectives were to evaluate the predictive potential of the TyG index for GDM, determine the optimal threshold value of the TyG index for GDM assessment, and compare the predictive performance of the TyG index alone versus its combination with maternal age and pre-pregnancy body mass index on GDM...
March 25, 2024: Lipids in Health and Disease
keyword
keyword
34028
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.