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https://www.readbyqxmd.com/read/28058025/relationship-between-ghrelin-helicobacter-pylori-and-gastric-mucosal-atrophy-in-hemodialysis-patients
#1
Hitomi Ichikawa, Mitsushige Sugimoto, Yukitoshi Sakao, Shu Sahara, Naro Ohashi, Akihiko Kato, Ken Sugimoto, Takahisa Furuta, Akira Andoh, Tadashi Sakao, Hideo Yasuda
AIM: To investigate the relationship between plasma ghrelin level, Helicobacter pylori (H. pylori) infection status and the severity of atrophy in hemodialysis patients. METHODS: One hundred eights patients who received hemodialysis and 13 non-hemodialysis H. pylori-negative controls underwent gastroduodenoscopy to evaluate the severity of gastric atrophy. Serum levels of pepsinogen (PG) were measured as serum markers of gastric atrophy. H. pylori infection was evaluated by anti-H...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28054994/synthesis-of-new-nitrofluoroquinolone-derivatives-with-novel-anti-microbial-properties-against-metronidazole-resistant-h-pylori
#2
Luay Abu-Qatouseh, Mohammad Abu-Sini, Amal Mayyas, Yusuf Al-Hiari, Rula Darwish, Talal Aburjai
One of the major therapeutic approaches to preventing relapse and accelerating the healing of duodenal and gastric ulcers is the eradication of Helicobacter pylori. Due to the emergence of antibiotic resistance among clinical strains of H. pylori, alternative approaches using newly discovered antimicrobial agents in combination with the standard regimens for the treatment of H. pylori are increasingly needed. The purpose of the present study was to investigate the effect of newly synthesized 8-nitroflouroqunolone derivatives when used either alone or when combined with metronidazole against metronidazole-resistant H...
January 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28049442/analyzing-the-influence-of-gastric-intestinal-metaplasia-on-gastric-ulcer-healing-in-helicobacter-pylori-infected-patients-without-atrophic-gastritis
#3
Li-Wei Chen, Liang-Che Chang, Chung-Ching Hua, Bor-Jen Hsieh, Shuo-Wei Chen, Rong-Nan Chien
BACKGROUND: Gastric epithelial hyper-proliferation was reported in patients with Helicobacter pylori (H. pylori)-infected gastric mucosa with intestinal metaplasia (IM) changes. In patients with gastric ulcer (GU) and IM, the GU may have a different healing rate in comparison to patients without IM. This study aimed to compare the difference in GU healing between H. pylori-infected patients with IM and those without IM. METHODS: We retrospectively analyzed patients at the Keelung Chung Gung Memorial Hospital during the period from March 2005 to January 2011...
January 3, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28045966/inhibition-of-helicobacter-pylori-and-its-associated-urease-by-palmatine-investigation-on-the-potential-mechanism
#4
Jiang-Tao Zhou, Cai-Lan Li, Li-Hua Tan, Yi-Fei Xu, Yu-Hong Liu, Zhi-Zhun Mo, Yao-Xing Dou, Rui Su, Zi-Ren Su, Ping Huang, Jian-Hui Xie
In this paper, we evaluated the anti-Helicobacter pylori activity and the possible inhibitory effect on its associated urease by Palmatine (Pal) from Coptis chinensis, and explored the potential underlying mechanism. Results indicated that Pal exerted inhibitory effect on four tested H. pylori strains (ATCC 43504, NCTC 26695, SS1 and ICDC 111001) by the agar dilution test with minimum inhibitory concentration (MIC) values ranging from 100 to 200 μg/mL under neutral environment (pH 7.4), and from 75 to 100 μg/mL under acidic conditions (pH 5...
2017: PloS One
https://www.readbyqxmd.com/read/28042765/study-of-serum-levels-of-some-oxidative-stress-markers-in-children-with-helicobacter-pylori-infection
#5
Adel A Hagag, Saleh M Amin, Rasha B El-Fiky, Magda E El-Sayad
BACKGROUND: Helicobacter pylori are gram-negative spiral shaped bacteria, with sheathed flagella. H. pylori infection is one of the most common chronic infections in humans. Infection is usually acquired during childhood, and becomes a lifelong infection in most people unless treated. The aim of this study was to evaluate serum levels of oxidative stress indices in children with H. pylori infection. MATERIAL AND METHODS: The present study was carried out on 60 children infected with H...
January 2, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28033692/helicobacter-pylori-and-its-virulence-factors-effect-on-serum-oxidative-dna-damages-in-adults-with-dyspepsia
#6
Heshmat Shahi, Rasoul Bahreiny, Somayeh Reiisi
Helicobacter Pylori infection is a common gastrointestinal infection that can cause pathological effects, increase oxidative stress and induce an inflammatory response in gastric mucosa. Inflammatory aspects may prompt the production of radical oxygen substance (ROS) which may damage cells and release 8-hydroxydyoxyguanosine (8-OHdG) to serum. In this study, we evaluate the prevalence of H. pylori virulence factors and the association between serum level of 8-OHdG, H. pylori infection, and its various virulence factors...
November 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/28024098/helicobacter-pylori-serology-testing-is-a-useful-diagnostic-screening-tool-for-symptomatic-inner-city-children
#7
Priya Raj, John F Thompson, Debra H Pan
AIM: This study assessed the Helicobacter pylori (H. pylori) serum antibody test as a diagnostic screening tool in symptomatic inner city children. METHODS: This was a retrospective study of patients aged 1-18 years who were referred to our paediatric gastroenterology department from 2009-2013. We included all patients who had H. pylori serum antibodies and, or, faecal antigens who underwent esophagogastroduodenoscopy (EGD) for histology, with or without a gastric tissue rapid urease test...
December 26, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/28011429/phytostabilization-of-zn-pb-ore-flotation-tailings-with-dianthus-carthusianorum-and-biscutella-laevigata-after-amending-with-mineral-fertilizers-or-sewage-sludge
#8
Krystyna Ciarkowska, Ewa Hanus-Fajerska, Florian Gambuś, Ewa Muszyńska, Tomasz Czech
Zinc-lead mining wastes remain largely unvegetated and prone to erosion for many years because of phytotoxic levels of residual heavy metals, low nutrient status and poor physical structure. The optimal solution for these areas is to restore plant cover using species which spontaneously appear on the spoils. These species are adapted to the conditions of tailings, and their establishment will promote further vegetation by increasing soil organic matter and development of a soil system capable of supporting the nutrient and water requirements of plants and microoorganisms...
December 20, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/28011200/synthesis-x-ray-molecular-structure-biological-evaluation-and-molecular-docking-studies-of-some-n-4-benzyl-substituted-5-nitroisatin-3-thiosemicarbazones
#9
Humayun Pervez, Nazia Khan, Sumera Zaib, Muhammad Yaqub, Muhammad Moazzam Naseer, Muhammad Nawaz Tahir, Jamshed Iqbal
A series of fifteen N(4)-benzyl substituted 5-nitroisatin-3-thiosemicarbazones 5a-o was synthesized and evaluated for urease inhibitory, phytotoxic and cytotoxic influences. All the compounds proved to be highly potent inhibitors of the enzyme, showing inhibitory activity (IC50=0.87±0.25-8.09±0.23μM) much better than the reference inhibitor, thiourea (IC50=22.3±1.12μM) and may thus act as persuasive leads for further studies. In phytotoxicity assay, twelve out of fifteen thiosemicarbazones tested i.e. 5a-e, 5g, 5i and 5k-o appeared to be active, exhibiting weak or non-significant (5-35%) growth inhibition at the highest tested concentrations (1000 or 500μg/mL)...
December 10, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27999644/comparison-of-levofloxacin-versus-clarithromycin-efficacy-in-the-eradication-of-helicobacter-pylori-infection
#10
Ali Akbar Haji-Aghamohammadi, Ali Bastani, Arash Miroliaee, Sonia Oveisi, Saeed Safarnezhad
BACKGROUND: Helicobacter pylori (H.pylori) infection causes multiple upper gastrointestinal diseases but optimal therapeutic regimen which can eradicate infection in all the cases has not yet been defined. This study was designed to evaluate the efficacy of triple levofloxacin-based versus clarithromycin-based therapy. METHODS: In this open-label randomized clinical trial study 120 patients who had esophagogastroduodenoscopy (EGD) with positive rapid urease test (RUT) were enrolled and divided into 2 groups...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27992819/a-comparative-study-on-the-influence-of-different-organic-amendments-on-trace-element-mobility-and-microbial-functionality-of-a-polluted-mine-soil
#11
P Abad-Valle, E Iglesias-Jiménez, E Álvarez-Ayuso
A mine soil heavily polluted with zinc and cadmium was employed to evaluate the capacity of organic amendments of different origin to simultaneously reduce soil trace element mobility and enhance soil microbial functionality. With this aim, four organic products, namely olive processing solid waste (OPSW), municipal solid waste compost (MSWC), leonardite and peat, were applied individually at different doses (0, 1, 2 and 5%) to mine soil under controlled laboratory conditions. Extraction studies and analysis of soil microbiological parameters (basal soil respiration and dehydrogenase, β-glucosidase, urease, arylsulfatase and acid and alkaline phosphatase activities) were performed to assess the effect of such amendments on soil restoration...
March 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/27976703/the-genome-of-rhizobiales-bacteria-in-predatory-ants-reveals-urease-gene-functions-but-no-genes-for-nitrogen-fixation
#12
Minna-Maria Neuvonen, Daniel Tamarit, Kristina Näslund, Juergen Liebig, Heike Feldhaar, Nancy A Moran, Lionel Guy, Siv G E Andersson
Gut-associated microbiota of ants include Rhizobiales bacteria with affiliation to the genus Bartonella. These bacteria may enable the ants to fix atmospheric nitrogen, but no genomes have been sequenced yet to test the hypothesis. Sequence reads from a member of the Rhizobiales were identified in the data collected in a genome project of the ant Harpegnathos saltator. We present an analysis of the closed 1.86 Mb genome of the ant-associated bacterium, for which we suggest the species name Candidatus Tokpelaia hoelldoblerii...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27936223/central-obesity-and-h-pylori-infection-influence-risk-of-barrett-s-esophagus-in-an-asian-population
#13
Chih-Cheng Chen, Yao-Chun Hsu, Ching-Tai Lee, Chia-Chang Hsu, Chi-Ming Tai, Wen-Lun Wang, Cheng-Hao Tseng, Chao-Tien Hsu, Jaw-Town Lin, Chi-Yang Chang
BACKGROUND AND AIM: The prevalence rates of Barrett's esophagus (BE) in western countries are higher than Asian ones, but little is known about their difference among risk factors of BE. The aim of this study is to investigate the associations of various risk factors including central obesity, body mass index (BMI), metabolic syndrome and H. pylori infection, with BE. METHODS: A total of 161 subjects with BE were enrolled and compared to age- and gender-matched controls randomly sampled (1:4) from check-up center in same hospital...
2016: PloS One
https://www.readbyqxmd.com/read/27922429/multiplex-pcr-for-detection-of-helicobacter-pylori-infection-in-gastric-biopsies-with-lower-inflammatory-score
#14
Najmiyatul Fadilah, Alfizah Hanafiah, Hamizah Razlan, Zin Qin Wong, Isa Mohamed Rose, Md Mostafizur Rahman
BACKGROUND: No gold standard has yet been established for the diagnosis of H. pylori infection. A multiplex polymerase chain reaction (mPCR) was developed in this study for rapid, sensitive and specific detection of H. pylori from gastric biopsies. METHODS: H. pylori infections were determined by in-house rapid urease test (iRUT), culture, histology and multiplex PCR. RESULTS: A total of 140 (60.9%) from 230 patients were positive for H. pylori infection...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27908539/design-synthesis-molecular-docking-anti-proteus-mirabilis-and-urease-inhibition-of-new-fluoroquinolone-carboxylic-acid-derivatives
#15
Mohammed A A Abdullah, Gamal El-Din A A Abuo-Rahma, El-Shimaa M N Abdelhafez, Heba A Hassan, Rehab M Abd El-Baky
New hydroxamic acid, hydrazide and amide derivatives of ciprofloxacin in addition to their analogues of levofloxacin were prepared and identified by different spectroscopic techniques. Some of the prepared compounds revealed good activity against the urease splitting bacteria, Proteus mirabilis. The urease inhibitory activity was investigated using indophenol method. Most of the tested compounds showed better activity than the reference acetohydroxamic acid (AHA). The ciprofloxacin hydrazide derivative 3a and levofloxacin hydroxamic acid 7 experienced the highest activity (IC50=1...
November 9, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27893682/peritoneal-dialysis-related-peritonitis-due-to-halomonas-hamiltonii-a-first-case-report
#16
Se Hwan Yeo, Jae Hoon Kwak, Yeo Un Kim, Jin Suk Lee, Hyo Jin Kim, Kyoung Hwa Park, Jung Sook Lee, Gyoung Yim Ha, Jeong Ho Lee, Jun Yeop Lee, Kyung Don Yoo
INTRODUCTION: Halomonas hamiltonii is a Gram-negative, halophilic, motile, and nonspore-forming rod bacterium. Although most Halomonas sp. are commonly found in saline environments, it has rarely been implicated as a cause of human infection. Herein, the authors present a case report of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis attributed to H hamiltonii. CASE PRESENTATION: An 82-year-old male patient who had been receiving CAPD therapy presented to an emergency department with complaints of abdominal pain and cloudy dialysate that had persisted for 2 days...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27892443/medication-adherence-pattern-and-factors-affecting-adherence-in-helicobacter-pylori-eradication-therapy
#17
S Shakya Shrestha, M Bhandari, S R Thapa, R Shrestha, R Poudyal, B Purbey, R B Gurung
Background Helicobacter pylori (H. pylori) infection is the most common chronic bacterial infection worldwide affecting approximately half of the world's population. A number of screening tests as well as complex multi-drug therapies are available for the detection and treatment of H. pylori infection. However, the optimum eradication rates of H. pylori infection can only be achieved if adherence to drug therapy is higher. Therefore, it is of utmost importance to determine the factors leading to poor adherence to obtain successful treatment outcomes...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27879042/high-antibiotic-resistance-of-helicobacter-pylori-and-its-effect-on-tailored-and-empiric-eradication-of-the-organism-in-lower-silesia-poland
#18
Stanisław Ferenc, Jan Gnus, Magdalena Kościelna, Małgorzata Kinda, Andriy Yarka, Luke Stewart, Wojciech Witkiewicz
BACKGROUND: At present, the resistance to antibiotics is considered the most important reason for Helicobacter pylori (HP) eradication failure. The aim of this study was to estimate the prevalence of antimicrobial resistance of HP strains and to evaluate tailored and empiric therapeutic regimens in patients with peptic ulcer disease associated with infection of this microorganism. MATERIALS AND METHODS: Between May 2011 and February 2013, 185 consecutive Polish patients with at least one positive Helicobacter pylori test (urease test, histopathologic examination, and/or culture) underwent eradication therapy...
November 23, 2016: Helicobacter
https://www.readbyqxmd.com/read/27821034/regression-of-gastric-de-novo-diffuse-large-b-cell-lymphoma-following-helicobacter-pylori-eradication-a-case-report
#19
M Saito, M Masutani, K Mabe, K Izumiyama, A Mori, T Irie, M Tanaka, M Morioka, M Tanino
We report a case of primary gastric diffuse large B-cell lymphoma (DLBCL), de novo DLBCL without the features of mucosa-associated lymphoid tissue (MALT) lymphoma, which regressed after Helicobacter pylori (HP) eradication. A 27-year-old Japanese female with epigastralgia was revealed to have ulcerated lesions in the angle and antral regions on gastroscopy. Biopsy specimen was consistent with a diagnosis of DLBCL without MALT lymphoma component, indicating de novo development. Her clinical staging on the Lugano system was Stage I...
July 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/27820723/characterization-of-the-gastric-microbiota-in-a-pediatric-population-according-to-helicobacter-pylori-status
#20
Laura Llorca, Guillermo Pérez-Pérez, Pedro Urruzuno, Maria Josefa Martinez, Tadasu Iizumi, Zhan Gao, Jiho Sohn, Jennifer Chung, Laura Cox, Aurea Simón-Soro, Alex Mira, Teresa Alarcón
BACKGROUND: H. pylori colonizes the human stomach of approximately 50% of the world's population, and increases the risk of several gastric diseases. The goal of this study is to compare the gastric microbiota in pediatric patients with and without H. pylori colonization. METHODS: We studied 51 children that underwent gastric endoscopy due to dyspeptic symptoms (18 H. pylori-positive and 33 negative). Gastric biopsies were obtained for Rapid Urease Test, culture, histology and DNA extraction...
November 3, 2016: Pediatric Infectious Disease Journal
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