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Implantation infertility

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https://www.readbyqxmd.com/read/28935366/review-diagnosis-and-impact-of-sperm-dna-alterations-in-assisted-reproduction
#1
REVIEW
Luke Simon, Benjamin R Emery, Douglas T Carrell
Sperm nuclear and chromatin abnormalities are common among infertile men and are known to influence natural reproduction. These abnormalities are also considered detrimental to normal fertilization, embryo development, and successful implantation and pregnancies following assisted reproductive treatment (ART). Abnormalities in the sperm nucleus can be broadly classified into sperm chromosomal abnormalities (aneuploidies) and sperm DNA abnormalities such as abnormal packing, DNA integrity, or DNA fragmentation...
August 2, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28915981/transcutaneous-electrical-acupoint-stimulation-improves-the-outcomes-of-in-vitro-fertilization-a-prospective-randomized-and-controlled-study
#2
Fan Qu, Fang-Fang Wang, Yan Wu, Jue Zhou, Nicola Robinson, Paul J Hardiman, Jie-Xue Pan, Yi-Jing He, Yu-Hang Zhu, Han-Zhi Wang, Xiao-Qun Ye, Ke-Lin He, Long Cui, Hong-Li Zhao, Ying-Hui Ye
OBJECTIVES: To explore whether transcutaneous electrical acupoint stimulation (TEAS) can improve the outcomes of in vitro fertilization (IVF). DESIGN: A prospective, randomized, and controlled study. SETTING: IVF center in a university hospital. PARTICIPANTS: Four hundred and eighty-one infertile patients with bilateral tubal blockage who were referred for IVF. Patients were randomized into four groups. INTERVENTION: TEAS was administered for 30min, respectively, at 24h before TVOR and two hours before ET...
September 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28914881/microrna-200c-impairs-uterine-receptivity-formation-by-targeting-fut4-and-%C3%AE-1-3-fucosylation
#3
Qin Zheng, Dandan Zhang, Y U Yang, Xinyuan Cui, Jiaqi Sun, Caixia Liang, Huamin Qin, Xuesong Yang, Shuai Liu, Qiu Yan
Successful embryo implantation requires the establishment of a receptive endometrium. Poor endometrial receptivity has generally been considered as a major cause of infertility. Protein glycosylation is associated with many physiological and pathological processes. The fucosylation is catalyzed by the specific fucosyltransferases. Fucosyltransferase IV (FUT4) is the key enzyme for the biosynthesis of α1,3-fucosylated glycans carried by glycoproteins, and the previous studies showed FUT4 expression changed dynamically during perimplantation...
September 15, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28913142/day-3-embryo-transfer-versus-day-5-blastocyst-transfers-a-prospective-randomized-controlled-trial
#4
Şafak Hatırnaz, Mine Kanat Pektaş
OBJECTIVE: This study aimed to show whether transferring day 5 embryos resulted in higher implantation and pregnancy rates than transferring day 3 embryos in Turkish women undergoing an intracytoplasmic sperm injection (ICSI) cycle. MATERIALS AND METHODS: A total of 190 women who had ICSI after retrieval of more than four oocytes on the day of fertilization check were randomly assigned to undergo embryo transfer either on day 3 or day 5. RESULTS: Day 3 and day 5 transfers were statistically similar with respect to the age of woman (p=0...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28911212/apposition-to-endometrial-epithelial-cells-activates-mouse-blastocysts-for-implantation
#5
Peter T Ruane, Stéphane C Berneau, Rebekka Koeck, Jessica Watts, Susan J Kimber, Daniel R Brison, Melissa Westwood, John D Aplin
STUDY QUESTION: How do interactions between blastocyst-stage embryos and endometrial epithelial cells regulate the early stages of implantation in an in vitro model? SUMMARY ANSWER: Mouse blastocyst apposition with human endometrial epithelial cells initiates trophectoderm differentiation to trophoblast, which goes on to breach the endometrial epithelium. WHAT IS KNOWN ALREADY: In vitro models using mouse blastocysts and human endometrial cell lines have proven invaluable in the molecular characterisation of embryo attachment to endometrial epithelium at the onset of implantation...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28904504/role-of-serpine-gene-polymorphism-in-recurrent-implantation-failure-and-preeclampsia
#6
Nidhi Sharma, Jayashree K Srinivasan, Margeret Harriet Priya, Venkatachalam Sibiya
This is a rare case of serpine gene polymorphism causing thrombophilia and recurrent implantation failure following intrauterine insemination. SERPINE1 gene encodes plasminogen activator inhibitor type 1 and inhibits fibrinolysis, or clot dissolution. The 4G variant results in increased expression of SERPINE1 and consequently higher inhibition of fibrinolysis, thus leading to thrombophilia. The patient had unexplained primary infertility for 9 years. Ovulation induction was done with gonadotropin releasing hormone (GnRH) agonist long protocol...
April 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28895679/a-modern-approach-to-the-management-of-patients-candidate-to-assisted-reproductive-technologies
#7
Roberta Venturella, Alberto Vaiarelli, Daniela Lico, Filippo M Ubaldi, Fulvio Zullo, Costantino DI Carlo
The growing use of Assisted Reproductive Technologies (ART) and the incorrect information from mass media, determined in the public the wrong idea that the right moment of life for programming a pregnancy can be delayed well beyond the physiological fertile age. Spare and insufficient health authorities' interventions are driven to explain to the general population the reduction of the fertility potential of couples and particularly of women with advancing age. This situation, characterized by more and more women seeking for pregnancy after age 38-40 imposes to specialists in Reproductive Medicine an honest and transparent counselling...
September 12, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28886319/morphokinetic-analysis-of-human-embryo-development-and-its-relationship-to-the-female-age-a-retrospective-time-lapse-imaging-study
#8
N Akhter, M Shahab
Time-lapse imaging technique has provided embryologists with a unique chance of studying the embryo morphokineticsto select the most viable embryos for implantation in the field of IVF (In vitro fertilization).The conventional method of morphological evaluations has proved that maternal age affects the human embryo quality. This retrospective study carried out at Islamabad Clinic Serving Infertile Couples, Islamabad, Pakistan mainly focuses on the effect of female age on human embryo morphokinetics. A total number of 200 patients undergoing ICSI treatment cycles at the clinic were selected for the study and divided into five age groups (< 26, 26-30, 31-35, 36-40, and > 40 years)...
August 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28868840/predicting-implantation-outcome-of-in-vitro-fertilization-and-intracytoplasmic-sperm-injection-using-data-mining-techniques
#9
Pegah Hafiz, Mohtaram Nematollahi, Reza Boostani, Bahia Namavar Jahromi
Background: In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two important subsets of the assisted reproductive techniques, used for the treatment of infertility. Predicting implantation outcome of IVF/ICSI or the chance of pregnancy is essential for infertile couples, since these treatments are complex and expensive with a low probability of conception. MATERIALS AND METHODS: In this cross-sectional study, the data of 486 patients were collected using census method...
October 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28865548/effects-of-adenomyosis-on-in%C3%A2-vitro-fertilization-treatment-outcomes-a-meta-analysis
#10
Grace Younes, Togas Tulandi
OBJECTIVE: To systematically review and summarize the existing evidence related to the effect of adenomyosis on fertility and on in vitro fertilization (IVF) clinical outcomes, and to explore the effects of surgical or medical treatments. DESIGN: Meta-analysis. SETTING: Not applicable. PATIENT(S): An electronic-based search was performed with the use of the following databases: Pubmed, Embase, Ovid Medline, Cochrane Central Register of Controlled Trials, and Google Scholar, identifying all related articles up to November 2016...
September 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28865547/does-the-use-of-calcium-ionophore-during-artificial-oocyte-activation-demonstrate-an-effect-on-pregnancy-rate-a-meta-analysis
#11
Sughashini Murugesu, Srdjan Saso, Benjamin P Jones, Timothy Bracewell-Milnes, Thanos Athanasiou, Anastasia Mania, Paul Serhal, Jara Ben-Nagi
OBJECTIVE: To study the effect, if any, of calcium ionophore as a method of artificial oocyte activation (AOA) on pregnancy outcomes and fertilization rates. DESIGN: Meta-analysis of randomized controlled trials, prospective observational and retrospective trials, case reports, and a case-control trial. SETTING: University-affiliated teaching hospital. PATIENT(S): Infertile couples undergoing fertilization treatment...
September 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28864986/the-role-of-maternal-nutrition-during-the-periconceptional-period-and-its-effect-on-offspring-phenotype
#12
Tom P Fleming, Judith J Eckert, Oleg Denisenko
The early preimplantation embryo has been rigorously studied for decades to understand inherent reproductive and developmental mechanisms driving its morphogenesis from before fertilisation through to and beyond implantation. Recent research has demonstrated that this short developmental window is also critical for the embryo's interaction with external, maternal factors, particularly nutritional status. Here, maternal dietary quality has been shown to alter the pattern of development in an enduring way that can influence health throughout the lifetime...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28864002/interleukin-11-classic-but-not-trans-signaling-is-essential-for-fertility-in-mice
#13
Maria Agthe, Yvonne Garbers, Tracy Putoczki, Christoph Garbers
The cytokine interleukin (IL)-11 activates its target cells through binding to the membrane-bound IL-11 receptor (IL-11R). Female mice deficient in IL-11R (Il11ra(-/-)) are infertile due to a defect in decidualization when the blastocyst implants. We have recently shown that IL-11 can also signal via a soluble IL-11R (trans-signaling). Which IL-11 pathway is required for fertility in mice is unknown. We confirm that female Il11ra(-/-)mice, lacking both classic and trans-signaling, are infertile. In contrast, the selective blockade of IL-11 trans-signaling does not affect fertility in mice...
September 2017: Placenta
https://www.readbyqxmd.com/read/28863933/window-of-implantation-transcriptomic-stratification-reveals-different-endometrial-subsignatures-associated-with-live-birth-and-biochemical-pregnancy
#14
Patricia Díaz-Gimeno, Maria Ruiz-Alonso, Patricia Sebastian-Leon, Antonio Pellicer, Diana Valbuena, Carlos Simón
OBJECTIVE: To refine the endometrial window of implantation (WOI) transcriptomic signature by defining new subsignatures associated to live birth and biochemical pregnancy. DESIGN: Retrospective cohort study. SETTING: University-affiliated in vitro fertilization clinic and reproductive genetics laboratory. PATIENT(S): Healthy fertile oocyte donors (n = 79) and patients with infertility diagnosed by Endometrial Receptivity Analysis (n = 771)...
August 29, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28854727/effect-of-randomized-serum-progesterone-concentration-on-secretory-endometrial-histologic-development-and-gene-expression
#15
Steven L Young, Ricardo F Savaris, Bruce A Lessey, Andrew M Sharkey, Ursula Balthazar, Richard J Zaino, Robert A Sherwin, Marc A Fritz
STUDY QUESTION: What doses of secretory phase progesterone (P) in women are associated with altered endometrial structure and/or function? SUMMARY ANSWER: Consistently delayed histological maturation was seen at the lowest tested daily P dose (2.5 mg), whereas consistently altered functional response, as reflected by microarray analysis of gene expression was seen at both the 5 and 2.5 mg doses. WHAT IS KNOWN ALREADY: Progesterone is absolutely required for normal embryo implantation and pregnancy survival...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28837027/expression-of-pgr-hbegf-itgav-itgb3-and-spp1-genes-in-eutopic-endometrium-of-infertile-women-with-endometriosis-during-the-implantation-window-a-pilot-study
#16
Michele G Da Broi, Carlos V Rocha, Juliana Meola, Wellington P Martins, Filomena M Carvalho, Rui A Ferriani, Paula A Navarro
OBJECTIVE: Alterations in endometrial receptivity may be involved in the etiopathogenesis of endometriosis-related infertility. The literature has suggested that patients with endometriosis present progestin resistance, which could affect embryo implantation. We question the presence of alterations in the expression of the progesterone receptor gene (PGR) and the genes related to endometrium-embryo interaction regulated by progesterone. This pilot study compared the expression of PGR, HBEGF, ITGAV, ITGB3, and SPP1 genes in eutopic endometrium during the implantation window (IW) in infertile women with endometriosis with that observed in the endometrium of fertile and infertile controls...
September 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28835940/pregnancy-outcome-of-delayed-start-gnrh-antagonist-protocol-versus-gnrh-antagonist-protocol-in-poor-responders-a-clinical-trial-study
#17
Abbas Aflatoonian, Aflatoonian Hosseinisadat, Ramesh Baradaran, Maryam Farid Mojtahedi
BACKGROUND: Management of poor-responding patients is still major challenge in assisted reproductive techniques (ART). Delayed-start GnRH antagonist protocol is recommended to these patients, but little is known in this regards. OBJECTIVE: The goal of this study was assessment of delayed-start GnRH antagonist protocol in poor responders, and in vitro fertilization (IVF) outcomes. MATERIALS AND METHODS: This randomized clinical trial included sixty infertile women with Bologna criteria for ovarian poor responders who were candidate for IVF...
April 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28828592/drug-delivery-for-the-treatment-of-endometriosis-and-uterine-fibroids
#18
REVIEW
David R Friend
Endometriosis and uterine fibroids (also known as uterine leiomyomas) are serious medical conditions affecting large numbers of women worldwide. Many women are asymptomatic but those with symptoms require medical intervention to relieve chronic pain and dysmenorrhea and to address infertility. Drug delivery has played a role in reducing some of the symptoms associated with endometriosis and uterine fibroids. Use of drug delivery systems for both conditions can roughly be divided into two categories: (1) existing systems designed for other indications such as contraception for symptomatic relief and (2) development of novel systems aimed at addressing some of the underlying biochemical changes associated with endometriosis and uterine fibroids such as oxidative stress, angiogenesis, and matrix degradation...
August 21, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28827707/juxtacrine-activity-of-estrogen-receptor-%C3%AE-in-uterine-stromal-cells-is-necessary-for-estrogen-induced-epithelial-cell-proliferation
#19
Wipawee Winuthayanon, Sydney L Lierz, Karena C Delarosa, Skylar R Sampels, Lauren J Donoghue, Sylvia C Hewitt, Kenneth S Korach
Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal cells, where the embryo is implanted during pregnancy. Without ESR1 in neighboring stroma cells, epithelial cells that line the inside of the uterus are unable to grow due to a lack of growth factors secreted from adjacent stromal cells. Moreover, loss of stromal ESR1 caused mice to deliver fewer pups due in part due to inability of some embryos to implant in the uterus, indicating that stromal ESR1 is crucial for uterine cell growth and pregnancy...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28826740/the-effect-of-parnaparin-sodium-on-in-vitro-fertilization-outcome-a-prospective-randomized-controlled-trial
#20
Corrado Lodigiani, Francesco Dentali, Elena Banfi, Paola Ferrazzi, Luca Librè, Ilaria Quaglia, Luca Cafaro, Emanuela Morenghi, Veronica Pacetti, Elena Zannoni, Anna Maria Baggiani, Paolo Emanuele Levi-Setti
INTRODUCTION: In-vitro and in-vivo models suggest the influence of low-molecular weight heparin on conception in infertile women undergoing in vitro fertilization procedures (IVF). In this randomized controlled trial we assessed whether a low-molecular weight heparin (parnaparin) could affect IVF outcomes. MATERIALS AND METHODS: 271cycles were analyzed in 247 women having a first or subsequent IVF cycle at Fertility Center of Humanitas Research Hospital. Patients, without severe thrombophilia and hormonal or active untreated autoimmune disorders, were randomly allocated (1:1) to receive for the whole cycle parnaparin, or routine hormonal therapy only...
August 15, 2017: Thrombosis Research
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