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Implantation infertility

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https://www.readbyqxmd.com/read/29149327/focused-time-lapse-analysis-reveals-novel-aspects-of-human-fertilization-and-suggests-new-parameters-of-embryo-viability
#1
G Coticchio, M Mignini Renzini, P V Novara, M Lain, E De Ponti, D Turchi, R Fadini, M Dal Canto
STUDY QUESTION: Can focused application of time-lapse microscopy (TLM) lead to a more detailed map of the morphokinetics of human fertilization, revealing novel or neglected aspects of this process? SUMMARY ANSWER: Intensive harnessing of TLM reveals novel or previously poorly characterised phenomena of fertilization, such as a cytoplasmic wave (CW) preceding pronuclear formation and kinetics of pronuclear chromatin polarization, thereby suggesting novel non-invasive biomarkers of embryo quality...
November 15, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29147461/the-role-of-antioxidant-enzymes-in-the-ovaries
#2
REVIEW
Shan Wang, Guolin He, Meng Chen, Tao Zuo, Wenming Xu, Xinghui Liu
Proper physiological function of the ovaries is very important for the entire female reproductive system and overall health. Reactive oxygen species (ROS) are generated as by-products during ovarian physiological metabolism, and antioxidants are indicated as factors that can maintain the balance between ROS production and clearance. A disturbance in this balance can induce pathological consequences in oocyte maturation, ovulation, fertilization, implantation, and embryo development, which can ultimately influence pregnancy outcomes...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29136189/serum-omega-3-fatty-acids-and-treatment-outcomes-among-women-undergoing-assisted-reproduction
#3
Y-H Chiu, A E Karmon, A J Gaskins, M Arvizu, P L Williams, I Souter, B R Rueda, R Hause, J E Chavarro
STUDY QUESTION: Are serum polyunsaturated fatty acids (PUFA) concentrations, including omega-3 (ω3-PUFA) and omega-6 (ω6-PUFA), related to ART outcomes? SUMMARY ANSWER: Serum levels of long-chain ω3-PUFA were positively associated with probability of live birth among women undergoing ART. WHAT IS KNOWN ALREADY: Intake of ω3-PUFA improves oocyte and embryo quality in animal and human studies. However, a recent cohort study found no relation between circulating ω3-PUFA levels and pregnancy rates after ART...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29132734/role-of-vitamin-e-and-d3-supplementation-in-intra-cytoplasmic-sperm-injection-outcomes-of-women-with-polycystic-ovarian-syndrome-a-double-blinded-randomized-placebo-controlled-trial
#4
Farnaz Fatemi, Afsaneh Mohammadzadeh, Mohammad Reza Sadeghi, Mohammad Mehdi Akhondi, Shayan Mohammadmoradi, Koorosh Kamali, Nicknam Lackpour, Sheida Jouhari, Simin Zafadoust, Sara Mokhtar, Ladan Giahi
BACKGROUND & AIMS: Ovulation induction has been proven to impose oxidative stress during ICSI treatment cycle. Also, data indicates that PCOS women show higher oxidative markers. Available data are not convincing about which antioxidant supplements have the potential to overcome oxidative stress in PCOS subjects. The aim of this trial was to investigate the possible role of combined vitamin E and D supplementation in the ICSI outcomes (oocyte number and quality, embryo number and quality, pregnancy rate) of PCOS subjects...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29113583/aberrant-akt-activation-during-implantation-window-in-infertile-women-with-intramural-uterine-fibroids
#5
Annu Makker, Madhu Mati Goel, Dipti Nigam, Abbas Ali Mahdi, Vinita Das, Anjoo Agarwal, Amita Pandey, Abnish Gautam
The objective of the study was to examine the expression and cellular distribution of key signaling components of the phosphatidylinositol-3-kinase (PI3K)/Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Protein Kinase B (PKB/Akt) pathway during the window of implantation in infertile women with noncavity-distorting intramural uterine fibroids (n = 21) as compared to fertile controls (n = 15). Relative gene expression analysis of PIK3CA, PTEN, Akt1, and Akt2 genes in midluteal endometrial biopsies was performed by real-time polymerase chain reaction...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29092905/estrogen-induces-egr1-to-fine-tune-its-actions-on-uterine-epithelium-by-controlling-pr-signaling-for-successful-embryo-implantation
#6
Hye-Ryun Kim, Yeon Sun Kim, Jung Ah Yoon, Seung Chel Yang, Mira Park, Dong-Won Seol, Sang Woo Lyu, Jin Hyun Jun, Hyunjung Jade Lim, Dong Ryul Lee, Haengseok Song
The harmonized actions of ovarian E2 and progesterone (P4) regulate the proliferation and differentiation of uterine cells in a spatiotemporal manner. Imbalances between these hormones often lead to infertility and gynecologic diseases. Whereas numerous factors that are involved in P4 signaling have been identified, few local factors that mediate E2 actions in the uterus have been revealed. Here, we demonstrate that estrogen induces the transcription factor, early growth response 1 (Egr1), to fine-tune its actions in uterine epithelial cells (ECs) that are responsible for uterine receptivity for embryo implantation...
November 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29080968/sex-selection-for-non-medical-indications-a-survey-of-current-pre-implantation-genetic-screening-practices-among-u-s-art-clinics
#7
Sarah M Capelouto, Sydney R Archer, Jerrine R Morris, Jennifer F Kawwass, Heather S Hipp
PURPOSE: This study aimed to determine the current percentage of United States (U.S.) assisted reproductive technology (ART) clinics offering sex selection via pre-implantation genetic screening (PGS) for non-medical purposes. METHODS: The authors conducted website review and telephone interview survey of 493 U.S. ART clinics performing in vitro fertilization (IVF) in 2017. Main outcome measures were pre-implantation genetic screening (PGS)/pre-implantation genetic diagnosis (PGD) practices and non-medical sex selection practices including family balancing...
October 28, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29070492/vitamin-d-deficiency-infertility-and-neurodevelopmental-diseases-attention-deficit-hyperactivity-disorder-autism-and-schizophrenia
#8
Michael J Berridge
The process of development depends on a progressive sequence of events that are carefully orchestrated by a number of signalling systems. Alteration in these signalling events results in infertility and neurodevelopmental diseases such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASD) and schizophrenia. A prominent role throughout development beginning at fertilization and continuing through early development, implantation and organ differentiation such as heart and brain development is regulated by Ca(2+) signalling...
October 25, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29069503/metabolomics-as-a-tool-to-identify-biomarkers-to-predict-and-improve-outcomes-in-reproductive-medicine-a-systematic-review
#9
Timothy Bracewell-Milnes, Srdjan Saso, Hossam Abdalla, Dimitrios Nikolau, Julian Norman-Taylor, Mark Johnson, Elaine Holmes, Meen-Yau Thum
BACKGROUND: Infertility is a complex disorder with significant medical, psychological and financial consequences for patients. With live-birth rates per cycle below 30% and a drive from the Human Fertilisation and Embryology Authority (HFEA) to encourage single embryo transfer, there is significant research in different areas aiming to improve success rates of fertility treatments. One such area is investigating the causes of infertility at a molecular level, and metabolomics techniques provide a platform for studying relevant biofluids in the reproductive tract...
November 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29063651/area-under-the-curve-of-temporal-estrogen-and-progesterone-measurements-during-assisted-reproductive-technology-which-hormone-is-the-main-determinant-of-cycle-outcome
#10
Enis Ozkaya, Tayfun Kutlu, Cigdem Abide Yayla, Semra Kayatas Eser, Ilhan Sanverdi, Belgin Devranoglu
AIM: Is there any relationship between estrogen and progesterone concentrations during assisted reproductive technology (ART)? Which hormone is the main determinant of impaired endometrial receptivity? METHODS: This study was conducted from July to December 2016 at the in vitro Fertilization/Intracytoplasmic Sperm Injection unit at Zeynep Kamil Women and Children's Health Training and Research Hospital. A total of 289 women who underwent ART were prospectively screened and areas under the curve of temporal estrogen (AUCEM) and progesterone measurements (AUCPM) were calculated for each participant...
October 24, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29063503/are-blastocyst-aneuploidy-rates-different-between-fertile-and-infertile-populations
#11
Jonathan D Kort, Rajiv C McCoy, Zach Demko, Ruth B Lathi
PURPOSE: This study aimed to determine if patients with infertility or recurrent pregnancy loss have higher rates of embryo aneuploidy than fertile controls. METHODS: This was a retrospective review of all pre-implantation genetic screening (PGS) cases processed by a single reference lab prior to March 2014 after a blastocyst biopsy. Cases were excluded if no indication for PGS was designated or patients were translocation carriers. The fertile control group consisted of patients undergoing IVF with PGS for sex selection only...
October 23, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29063502/arabian-peninsula-ethnicity-is-associated-with-lower-ovarian-reserve-and-ovarian-response-in-women-undergoing-fresh-icsi-cycles
#12
Aya M Tabbalat, Nigel Pereira, Devon Klauck, Clara Melhem, Rony T Elias, Zev Rosenwaks
PURPOSE: Recent studies have demonstrated that ethnicity can be an independent determinant of assisted reproductive technology (ART) outcomes. In this context, we investigate whether ART outcomes differ between Arabian Peninsula and Caucasian women. METHODS: This is a retrospective cohort study of women undergoing fresh intracytoplasmic sperm injection (ICSI)-embryo transfer (ET) cycles for male factor infertility. The study cohort was divided into 2 groups based on ethnicity-Arabian Peninsula or Caucasian...
October 23, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29040638/low-serum-progesterone-on-the-day-of-embryo-transfer-is-associated-with-a-diminished-ongoing-pregnancy-rate-in-oocyte-donation-cycles-after-artificial-endometrial-preparation-a-prospective-study
#13
E Labarta, G Mariani, N Holtmann, P Celada, J Remohí, E Bosch
STUDY QUESTION: Is there a relationship between serum progesterone (P) and endometrial volume on the day of embryo transfer (ET) with ongoing pregnancy rate (OPR) in artificial endometrium preparation cycles? SUMMARY ANSWER: Patients with serum P < 9.2 ng/ml on the day of ET had a significantly lower OPR but endometrial volume was not related with OPR. WHAT IS KNOWN ALREADY: A window of optimal serum P levels during the embryo implantation period has been described in artificial endometrium preparation cycles...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040606/pinopode-score-around-the-time-of-implantation-is-predictive-of-successful-implantation-following-frozen-embryo-transfer-in-hormone-replacement-cycles
#14
X Y Jin, L J Zhao, D H Luo, L Liu, Y D Dai, X X Hu, Y Y Wang, X Lin, F Hong, T C Li, S Y Zhang
STUDY QUESTION: Is pinopode measurement of any prognostic value? SUMMARY ANSWER: Pinopode expression was significantly associated with the occurrence of pregnancy after frozen embryo transfer. WHAT IS KNOWN ALREADY: Pinopodes are expressed in the endometrium during the implantation period. Pinopode measurement has been proposed as a marker of endometrial receptivity. STUDY DESIGN, SIZE, DURATION: A prospective cohort study was conducted at the Center of Reproductive Medicine, Sir Run Run Shaw Hospital, between 2014 and 2016, recruiting 172 women with infertility and undergoing frozen embryo transfer following IVF treatment...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29036275/porcupine-dependent-wnt-activity-within-the-uterine-epithelium-is-essential-for-fertility
#15
Omar Farah, Steffen Biechele, Janet Rossant, Daniel Dufort
The secretion of mammalian Wnt ligands within the cell is dependent on the activity of Porcupine, a gene located on the X-chromosome that encodes for a membrane bound o-acyl transferase. Here, we report that post-natal ablation of Porcupine in the uterine luminal epithelium alone results in the decrease in endometrial gland number. Despite having uterine glands, mutant females are completely infertile. Epithelial ablation of Porcupine causes defects in timely apposition of the lumen, along with failure to respond to artificial decidual induction...
October 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29029020/the-endometrial-polarity-paradox-differential-regulation-of-polarity-within-secretory-phase-human-endometrium
#16
Sarah Whitby, Lois A Salamonsen, Jemma Evans
A major cause of infertility in normal and assisted reproduction cycles is failure of the endometrium to undergo appropriate changes during the secretory phase of the menstrual cycle as it acquires receptivity for an implanting blastocyst. Current dogma states that loss of epithelial polarity in the luminal epithelial cells, the point of first contact between maternal endometrium and blastocyst, may facilitate embryo implantation. Loss of polarity is likely an important change during the secretory phase to overcome mutual repulsion between otherwise polarised epithelial surfaces...
September 29, 2017: Endocrinology
https://www.readbyqxmd.com/read/29026720/efficacy-of-embryo-transfer-on-day-2-versus-day-3-according-to-maternal-age-in-patients-with-normal-ovarian-response
#17
Jung-Woo Lee, Jeong-Ho Cha, Sun-Hee Shin, Yun-Jeong Kim, Seul-Ki Lee, Choon-Keun Park, Kyung-Ah Pak, Ji-Sung Yoon, Seo-Young Park
OBJECTIVE: Delaying embryo transfer (ET) enables us to select among the embryos available for transfer and is associated with positive effects on implantation and pregnancy outcomes. However, the optimal day for ET of human cleavage-stage embryos remains controversial. METHODS: A retrospective study of 3,124 in vitro fertilization/intracytoplasmic sperm injection cycles (2,440 patients) was conducted. We compared the effects of day 2 and 3 ET on rates of implantation and pregnancy outcomes between young maternal age (YMA; <38 years old, n=2,295) and old maternal age (OMA; ≥38 years old, n=829) patient groups...
September 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29025102/effects-of-noncavity-distorting-fibroids-on-endometrial-gene-expression-and-function
#18
Lusine Aghajanova, Sahar Houshdaran, Juan C Irwin, Linda C Giudice
Uterine fibroids are a common finding in infertility patients. Impaired implantation and decidualization have been proposed to contribute to compromised fertility. Data are limited on the endometrial transcriptome from subjects with uterine fibroids, as well as endometrial receptivity and decidualization potential of endometrial stromal fibroblasts (eSF) from women with fibroids. Our objective was to investigate the endometrial transcriptome of women with noncavity-distorting intramural fibroids and compare them to control subjects with no uterine pathology throughout the menstrual cycle...
October 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29025060/adrenomedullin-improves-fertility-and-promotes-pinopodes-and-cell-junctions-in-the-peri-implantation-endometrium
#19
Brooke C Matson, Stephanie L Pierce, Scott T Espenschied, Eric Holle, Imani H Sweatt, Eric S Davis, Robert Tarran, Steven L Young, Trudy A Kohout, Marcel van Duin, Kathleen M Caron
Implantation is a complex event demanding contributions from both embryo and endometrium. Despite advances in assisted reproduction, endometrial receptivity defects persist as a barrier to successful implantation in women with infertility. We previously demonstrated that maternal haploinsufficiency for the endocrine peptide adrenomedullin (AM) in mice confers a subfertility phenotype characterized by defective uterine receptivity and sparse epithelial pinopode coverage. The strong link between AM and implantation suggested the compelling hypothesis that administration of AM prior to implantation may improve fertility, protect against pregnancy complications, and ultimately lead to better maternal and fetal outcomes...
September 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024799/treatment-for-uterine-isthmocele-a-pouch-like-defect-at-the-site-of-cesarean-section-scar
#20
REVIEW
Antonio Setubal, João Alves, Filipa Osório, Adalgisa Guerra, Rodrigo Fernandes, Jaime Albornoz, Zacharoula Sidiroupoulou
Isthmocele appears as a fluid pouch-like defect in the anterior uterine wall at the site of a prior Cesarean section and ranges in prevalence from 19% to 84%, a direct relation to the increase in Cesarean sections performed worldwide. Many definitions have been suggested for the dehiscence resulting from Cesarean section, and we propose standardization with a single term for all cases: isthmocele. Patients are not always symptomatic, but symptoms typically include intermittent abnormal bleeding, pain, and infertility...
October 9, 2017: Journal of Minimally Invasive Gynecology
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