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Implantation infertility

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https://www.readbyqxmd.com/read/28090464/the-efficacy-of-intrauterine-instillation-of-granulocyte-colony-stimulating-factor-in-infertile-women-with-a-thin-endometrium-a-pilot-study
#1
Dayong Lee, Jae Dong Jo, Seul Ki Kim, Byung Chul Jee, Seok Hyun Kim
OBJECTIVE: The study aimed to investigate the efficacy of intrauterine instillation of granulocyte colony-stimulating factor (G-CSF) on the day of ovulation triggering or oocyte retrieval in infertile women with a thin endometrium. METHODS: Fifty women whose endometrial thickness (EMT) was ≤8 mm at the time of triggering during at least one previous in vitro fertilization (IVF) cycle and an index IVF cycle were selected. On the day of triggering (n=12) or oocyte retrieval (n=38), 300 µg of G-CSF was instilled into the uterine cavity...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28090456/chronic-endometritis-and-infertility
#2
REVIEW
Hyun Jong Park, You Shin Kim, Tae Ki Yoon, Woo Sik Lee
Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-existence between microorganisms and the host immune system in the endometrium. A majority of CE cases produce no noticeable signs or mild symptoms, and the prevalence rate of CE has been found to be approximately 10%. Gynecologists and pathologists often do not focus much clinical attention on CE due to the time-consuming microscopic examinations necessary to diagnose CE, its mild clinical manifestations, and the benign nature of the disease...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28074124/involvement-of-blood-mononuclear-cells-in-the-infertility-age-associated-diseases-and-cancer-treatment
#3
REVIEW
Antonin Bukovsky
Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo...
December 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28073982/urinary-triclosan-concentrations-and-early-outcomes-of-in-vitro-fertilization-embryo-transfer
#4
Rui Hua, Yao Zhou, Biao Wu, Zhongwei Huang, Yongtong Zhu, Yali Song, Yanhong Yu, Hong Li, Song Quan
Triclosan (TCS) exists ubiquitously in the environment. Several in vitro and in vivo studies have demonstrated that TCS exerts endocrine disruptive effects on reproduction, but data from human populations are limited and conflicting. The objective of our study was to investigate whether high urinary TCS concentration is adversely associated with early reproductive outcomes in women undergoing in vitro fertilization-embryo transfer (IVF-ET). This prospective cohort study was conducted from September 2015 to June 2016, including 156 infertile women undergoing their first IVF-ET cycle...
March 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28069482/ovarian-response-and-in-vitro-fertilization-outcomes-after-salpingectomy-does-salpingectomy-indication-matter
#5
Nigel Pereira, Katherine P Pryor, Anna Voskuilen-Gonzalez, Jovana P Lekovich, Rony T Elias, Steven D Spandorfer, Zev Rosenwaks
STUDY OBJECTIVE: To investigate whether the ovarian response and pregnancy outcomes of patients undergoing in vitro fertilization (IVF) after salpingectomy is affected by the underlying indication for salpingectomy. DESIGN: Retrospective cohort study. DESIGN: Classification: II-3. SETTING: University-affiliated fertility center. PATIENTS: All patients <37 years of age undergoing IVF within 12 months of laparoscopic salpingectomy...
January 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28069183/evaluation-of-in%C3%A2-vitro-fertilization-outcomes-using-interleukin-8-in-culture-medium-of-human-preimplantation-embryos
#6
Guanyou Huang, Congrong Zhou, Chi-Ju Wei, Shuyun Zhao, Fa Sun, Hua Zhou, Wenjie Xu, Jun Liu, Chao Yang, Lingfei Wu, Guidan Ye, Zhuo Chen, Yongli Huang
OBJECTIVE: To investigate whether selected cytokines are detectable in the embryo culture medium (EM) of human preimplantation embryos (HPE) and what the relationship is of the cytokines with clinical outcomes. DESIGN: Cross-sectional study. SETTING: University-affiliated tertiary teaching hospital. PATIENT(S): Three-hundred and thirty infertile women who underwent fresh cycle in vitro fertilization (IVF) between January and December 2014...
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28054230/tumor-necrosis-factor-alpha-and-pregnancy-focus-on-biologics-an-updated-and-comprehensive-review
#7
REVIEW
Jaume Alijotas-Reig, Enrique Esteve-Valverde, Raquel Ferrer-Oliveras, Elisa Llurba, Josep Maria Gris
Tumor necrosis factor-α (TNF-α) is a central regulator of inflammation, and TNF-α antagonists may be effective in treating inflammatory disorders in which TNF-α plays a major pathogenic role. TNF-α has also been associated with inflammatory mechanisms related to implantation, placentation, and pregnancy outcome. TNF-α is secreted by immune cells and works by binding to TNFR1 and TNFR2 cell receptors. TNF-α is also related to JAK/STAT pathways, which opens up hypothetical new targets for modifying. The accurate balance between Th1 cytokines, mainly TNF-α, Th17, and Th2, particularly IL-10 is essential to achieve good obstetric outcomes...
January 4, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28051220/the-influence-of-gonadotropins-on-clinico-biological-icsi-outcome-a-retrospective-comparative-study-rfsh-vs-hp-hmg
#8
Abdeljalil Khlifi, Olfa Kacem, Maher Maroueni, Leila Elgoul, Samir Hidar, Meriem Fekih, Sassi Boughizane, Habib Essaidi, Lassad Ben Regaya, Mohamed Bibi, Mounir Ajina, Hedi Khairi
Objective To investigate the difference in the outcome of ICSI-ET cycles among respondents patients, taking into account the molecule inducer of controlled ovarian stimulation: HP-hMG ou rFSH. Patients and Methods A comparative retrospective study over 62 months including a total of 1005 infertile couples, divided into two groups: HP-HMG (n=125) and rFSH (n=880). Results - The average numbers of retrieved oocytes and matures oocytes were significantly higher in rFSH group rFSH (7,94 ± 2,49, HP-HMG vs 9,05 ± 3,40, rFSH, p=0...
June 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28049832/forkhead-box-a2-foxa2-is-essential-for-uterine-function-and-fertility
#9
Andrew M Kelleher, Wang Peng, James K Pru, Cindy A Pru, Francesco J DeMayo, Thomas E Spencer
Establishment of pregnancy is a critical event, and failure of embryo implantation and stromal decidualization in the uterus contribute to significant numbers of pregnancy losses in women. Glands of the uterus are essential for establishment of pregnancy in mice and likely in humans. Forkhead box a2 (FOXA2) is a transcription factor expressed specifically in the glands of the uterus and is a critical regulator of postnatal uterine gland differentiation in mice. In this study, we conditionally deleted FOXA2 in the adult mouse uterus using the lactotransferrin Cre (Ltf-Cre) model and in the neonatal mouse uterus using the progesterone receptor Cre (Pgr-Cre) model...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28049501/the-abnormal-expression-of-oxytocin-receptors-in-the-uterine-junctional-zone-in-women-with-endometriosis
#10
Miaomaio Huang, Xuqing Li, Peipei Guo, Zhaojuan Yu, Yuting Xu, Zhaolian Wei
BACKGROUND: The junctional zone (JZ), also called as the endometrial-myometrial junction, is related to peristaltic-like movements in the non-pregnant uterus. Hyperperistalsis and dysperistalsis of uterus constructions might underlie many important disorders such as dysmenorrhea, infertility, endometriosis, implantation failure. The major proteins for uterine contraction of the non-pregnant uterus may be Oxytocin (OT) and oxytocin receptor (OTR). The objective of this study was to inspect the expression of OTR in isthmic and mid-fundal parts of the uterine junctional zone at different stages of the follicular cycle in patients with and without endometriosis...
January 3, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28046063/three-dimensional-high-frequency-ultrasonography-for-early-detection-and-characterization-of-embryo-implantation-site-development-in-the-mouse
#11
Mary C Peavey, Corey L Reynolds, Maria M Szwarc, William E Gibbons, Cecilia T Valdes, Francesco J DeMayo, John P Lydon
Ultrasonography is a powerful tool to non-invasively monitor in real time the development of the human fetus in utero. Although genetically engineered mice have served as valuable in vivo models to study both embryo implantation and pregnancy progression, such studies usually require sacrifice of parous mice for subsequent phenotypic analysis. To address this issue, we used three-dimensional (3-D) reconstruction in silico of high-frequency ultrasound (HFUS) imaging data for early detection and characterization of murine embryo implantation sites and their development in utero...
2017: PloS One
https://www.readbyqxmd.com/read/28042415/chances-to-have-a-boy-after-gender-selection-by-pre-implantation-genetic-screening-are-reduced-in-couples-with-only-girls-and-without-a-boy-sired-by-the-male-partner
#12
Soryya Panahi, Fariba Fahami, Mohammad Reza Deemeh, Marziyeh Tavalaee, Hamid Gourabi, Mohammad Hossain Nasr-Esfahani
BACKGROUND: Gender selection and family planning have their roots in human history. Despite great interest in these fields, very few scientific propositions exist which could explain why some family do not attain the desired sex. Therefore, the aim of this study was to evaluate whether sex of previous child or children could affect the outcomes of pre-implantation genetic screening (PGS). MATERIALS AND METHODS: This historical cohort study including 218 PGS cases referring to Isfahan Fertility and Infertility Center (IFIC)...
January 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28040414/reproductive-outcomes-of-ivf-patients-with-unicornuate-uteri
#13
Kemal Ozgur, Hasan Bulut, Murat Berkkanoglu, Kevin Coetzee
In this retrospective observational study, the pregnancy, perinatal and obstetric outcomes of patients diagnosed with unicornuate uteri were compared with those of patients with normal uteri after undergoing intracytoplasmic sperm injection (ICSI) with fresh and cryopreserved embryo transfer. From a select population of 9676 infertile patients receiving IVF treatment, 75 (0.78%) were diagnosed with unicornuate uteri between January 2009 and December 2015. Fifty of them underwent ICSI treatment, with 90 fresh and cryopreserved embryo transfers...
December 23, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28010150/repeated-doses-of-gnrh-antagonist-at-midcycle-in-artificial-frozen-embryo-transfer-cycles-may-not-affect-pregnancy-outcomes
#14
Katherine L Palmerola, Jennifer Y Hsu, Lisa C Grossman, Mark V Sauer, Roger A Lobo
No significant differences in outcomes have been found between protocols of endometrial preparation for frozen embryo transfer (FET), though gonadotropin releasing hormone (GnRH) antagonists may have detrimental effects on the endometrium. We conducted a retrospective cohort noninferiority study at a single academic center of women receiving multiple doses of mid-cycle GnRH antagonist (GAnt) to those receiving GnRH agonist (GAg) to determine if there are detrimental effects of GnRH antagonists. 1047 FET cycles were identified, detailed data was available in 840 cycles: 610 GAg and 230 GAnt cycles...
December 23, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28005395/conditional-ablation-of-progesterone-receptor-membrane-component-2-causes-female-premature-reproductive-senescence
#15
N C Clark, C A Pru, S P Yee, J P Lydon, J J Peluso, J K Pru
The non-classical progesterone receptors, progesterone receptor membrane component (PGRMC) 1 and PGRMC2 have been implicated in regulating cell survival of endometrial and ovarian cells in vitro and are abundantly expressed in these cell types. The objective of this study was to determine if Pgrmc1 and Pgrmc2 are essential for normal female reproduction. To accomplish this objective, Pgrmc1 and/or Pgrmc2 floxed mice (Pgrmc2(fl/fl) and Pgrmc1/2(fl/fl)) were crossed with Pgr-cre mice which resulted in the conditional ablation of Pgrmc1 and/or Pgrmc2 from female reproductive tissues (i...
December 22, 2016: Endocrinology
https://www.readbyqxmd.com/read/28004075/regulation-of-reproduction-by-the-circadian-rhythms
#16
Wen-Xiang Zhang, Si-Yu Chen, Chang Liu
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in the environment. Circadian rhythm is controlled by the central clock in the hypothalamic suprachiasmatic nucleus (SCN) and the peripheral clocks in various tissues. More importantly, the central clock can integrate photic/nonphotic signals to generate rhythmic outputs, and then drive the slave oscillators in peripheral tissues through neuroendocrine and behavioral signals. Human reproductive activities, as some other physiological functions, are controlled by the biological clocks...
December 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28003919/successful-pregnancy-outcome-in-women-with-recurrent-ivf-failure-and-anti-hcg-autoimmunity-a-report-of-three-cases
#17
Valeria Muller, Ksenia Ob'edkova, Inna Krikheli, Igor Kogan, Irina Fedorova, Elena Lesik, Evgenia Komarova, Alexandr Gzgzyan
We report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmapheresis, combined prednisolone, and intravenous immunoglobulin therapy. No adverse side effects were observed; all cases resulted in pregnancy and subsequent life births. In order to be given an adequate efficient treatment, women with recurrent implantation failure should be suspected for autoimmune factor of infertility and its possible association with anti-hCG autoimmunity...
2016: Case Reports in Immunology
https://www.readbyqxmd.com/read/27939940/expression-of-er-%C3%AE-and-er-%C3%AE-during-peri-implantation-period-in-uterus-is-essential-for-implantation-and-decidualization-in-golden-hamster
#18
Randhir Kumar, Akhilesh Yadav, P L Pakrasi
AIMS: The role of estrogen in embryo implantation in golden hamster (Mesocricetus auratus) is still ambiguous. In order to clarify it, we investigated the spatial distribution and expression of estrogen receptors, ER-α and ER-β in the uterus of pregnant hamster during peri-implantation period and identified the effect of estrogen receptor antagonist ICI-182,780 on the embryo implantation. MAIN METHODS: We performed in vivo experiments on early pregnant hamsters involving treatment with ICI-182,780, an estrogen receptor antagonist...
December 6, 2016: Life Sciences
https://www.readbyqxmd.com/read/27932897/effect-of-ovarian-endometrioma-on-uterine-and-ovarian-blood-flow-in-infertile-women
#19
Akmal El-Mazny, Ahmed Kamel, Wafaa Ramadan, Sherine Gad-Allah, Suzy Abdelaziz, Ahmed M Hussein
BACKGROUND: Angiogenesis has been found to be among the most important factors in the pathogenesis of endometriosis. The formation of new blood vessels is critical for the survival of newly implanted endometriotic foci. The use of 3-D power Doppler allows for the demonstration of the dynamic vascular changes that occur during the process of in vitro fertilization (IVF). We aimed to evaluate the effect of ovarian endometrioma on uterine and ovarian blood flow in infertile women. MATERIALS AND METHODS: In a case-control study at a university teaching hospital, 138 women with unilateral ovarian endometrioma scheduled for IVF were compared to 138 women with male-factor or unexplained infertility...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27927849/the-effect-of-serum-vitamin-d-levels-on-ovarian-reserve-markers-a-prospective-cross-sectional-study
#20
Panagiotis Drakopoulos, Arne van de Vijver, Valerie Schutyser, Stevan Milatovic, Ellen Anckaert, Johan Schiettecatte, Christophe Blockeel, Michel Camus, Herman Tournaye, Nikolaos P Polyzos
STUDY QUESTION: Is there any association between serum 25-OH vitamin D levels and ovarian reserve markers in infertile women? SUMMARY ANSWER: Vitamin D is not associated with the ovarian reserve markers, anti-mullerian hormone (AMH) and antral follicle count (AFC), in infertile women. WHAT IS KNOWN ALREADY: The mechanism underlying the relationship between vitamin D deficiency and reproduction is still unclear; however, evidence indicates a potential direct negative impact on ovarian function...
January 2017: Human Reproduction
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