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JOURNAL ARTICLE
Kuan-Chih Huang, Donna Shu-Han Lin, Geng-Shi Jeng, Ting-Tse Lin, Lian-Yu Lin, Chih-Kuo Lee, Lung-Chun Lin
The left ventricular global longitudinal strain (LVGLS) is a crucial prognostic indicator. However, inconsistencies in measurements due to the speckle tracking algorithm and manual adjustments have hindered its standardization and democratization. To solve this issue, we proposed a fully automated strain measurement by artificial intelligence-assisted LV segmentation contours. The LV segmentation model was trained from echocardiograms of 368 adults (11,125 frames). We compared the registration-like effects of dynamic time warping (DTW) with speckle tracking on a synthetic echocardiographic dataset in experiment-1...
April 19, 2024: J Imaging Inform Med
#2
JOURNAL ARTICLE
Zhisheng Gui, Shengyi Gong, Guoqiang Feng
Dual-state emissive (DSE) materials exhibit fluorescence in both solid and solution states and have become an emerging material in the fields of materials science and sensing in recent years. However, due to the lack of effective and universal preparation methods, DSE materials, especially those with long emission wavelengths, are still scarce. Developing an effective method for constructing such DSE molecules is urgently needed. In this study, we constructed three DSE molecules ( NRP-Boc , DCIP-Boc , and DCMP-Boc ) with far-red to near-infrared fluorescence by simply modifying three traditional aggregation-caused quenching (ACQ) fluorophores with tert -butyloxycarbonyl (Boc) groups...
April 18, 2024: Analytical Chemistry
#3
JOURNAL ARTICLE
Shijun Gao, Peyton N Oden, Benjamin J Ryan, Haozhe Yang, Bret D Freudenthal, Marc M Greenberg
N6-(2-deoxy-α,β-d-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamido-pyrimidine (Fapy•dG) is formed from a common intermediate and in comparable amounts to the well-studied mutagenic DNA lesion 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OxodGuo). Fapy•dG preferentially gives rise to G → T transversions and G → A transitions. However, the molecular basis by which Fapy•dG is processed by DNA polymerases during this mutagenic process remains poorly understood. To address this we investigated how DNA polymerase β (Pol β), a model mammalian polymerase, bypasses a templating Fapy•dG, inserts Fapy•dGTP, and extends from Fapy•dG at the primer terminus...
April 18, 2024: Nucleic Acids Research
#4
JOURNAL ARTICLE
Maryam Aryafar, Mohammad Mahdavi, Hossein Shahzadi, Yeganeh Rajabpour Ranjbar, Mohammad Hassan Sohouli, Sina Afzal, Asal Neshatbini Tehrani, Danial Fotros, Ghazal Daftari
BACKGROUND: Dilated cardiomyopathy (DCMP) is characterized by the enlargement and weakening of the heart and is a major cause of heart failure in children. Infection and nutritional deficiencies are culprits for DCMP. Zinc is an important nutrient for human health due to its anti-oxidant effect that protects cell against oxidative damage. This case-control study aimed to investigate the relationship between dietary intake of zinc and selenium and the risk of DCMP in pediatric patients...
April 11, 2024: BMC Pediatrics
#5
JOURNAL ARTICLE
Megumi Sasatani, Yang Xi, Kazuhiro Daino, Atsuko Ishikawa, Yuji Masuda, Junko Kajimura, Jinlian Piao, Elena Karamfilova Zaharieva, Hiroaki Honda, Guanyu Zhou, Kanya Hamasaki, Yoichiro Kusunoki, Tsutomu Shimura, Shizuko Kakinuma, Yoshiya Shimada, Kazutaka Doi, Tomoko Ishikawa-Fujiwara, Yusuke Sotomaru, Kenji Kamiya
Rev1 has two important functions in the translesion synthesis pathway, including dCMP transferase activity, and acts as a scaffolding protein for other polymerases involved in translesion synthesis. However, the role of Rev1 in mutagenesis and tumorigenesis in vivo remains unclear. We previously generated Rev1-overexpressing (Rev1-Tg) mice and reported that they exhibited a significantly increased incidence of intestinal adenoma and thymic lymphoma (TL) after N-methyl-N-nitrosourea (MNU) treatment. In this study, we investigated mutagenesis of MNU-induced TL tumorigenesis in wild-type (WT) and Rev1-Tg mice using diverse approaches, including whole-exome sequencing (WES)...
April 4, 2024: Cancer Science
#6
Shijun Gao, Peyton N Oden, Benjamin J Ryan, Haozhe Yang, Bret D Freudenthal, Marc M Greenberg
N6-(2-deoxy-α,β-D-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamido-pyrimidine (Fapy•dG) is formed from a common intermediate and in comparable amounts to the well-studied mutagenic DNA lesion 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OxodGuo). Fapy•dG preferentially gives rise to G → T transversions and G → A transitions. However, the molecular basis by which Fapy•dG is processed by DNA polymerases during this mutagenic process remains poorly understood. To address this we investigated how DNA polymerase β (Pol β), a model mammalian polymerase, bypasses a templating Fapy•dG, inserts Fapy•dGTP, and extends from Fapy•dG at the primer terminus...
January 16, 2024: bioRxiv
#7
JOURNAL ARTICLE
Jérôme Jouan, Damian Craiem, Gilles Soulat, Virginie Bliah, Ignacio Masari, Elie Mousseaux
OBJECTIVES: Secondary functional tricuspid regurgitation (FTR) management remains controversial mainly due to the lack of knowledge in its pathogenesis and the difficulties to measure the actual dimensions of tricuspid annulus (TA) with current imaging methods. Using a novel method based on multiphase cardiac computed tomography (CT) scan acquisition to accurately analyze the right atrioventricular junction size, we sought to explore modifications of TA morphometry and dynamics in secondary FTR...
December 2023: JTCVS open
#8
JOURNAL ARTICLE
Dominic A Caputa, Quin P Blankenship, Zachary D Smith, Molly M Huebner, Zoe A Vetter, Richard W Parks, Saul Armendariz Lobera, Emmett M Leddin, Cooper A Taylor, Carol A Parish, Bill R Miller
Cancer is one of the leading causes of death in the U.S., and tumorous cancers such as cervical, lung, breast, and ovarian cancers are the most common types. APOBEC3B is a nonessential cytidine deaminase found in humans and theorized to defend against viral infection. However, overexpression of APOBEC3B is linked to cancer in humans, which makes APOBEC3B a potential cancer treatment target through competitive inhibition for several tumorous cancers. Computational studies can help reveal a small molecule inhibitor using high-throughput virtual screening of millions of candidates with relatively little cost...
December 18, 2023: Journal of Biomolecular Structure & Dynamics
#9
JOURNAL ARTICLE
Heng Liang, Jeffrey P Mower, Catherine P Chia
The de novo synthesis of dTTP uses several pathways: gram-negative bacteria use dCTP deaminase (Dcd) to convert dCTP into dUTP, whereas eukaryotes and gram-positive bacteria instead use dCMP deaminase to transform dCMP to dUMP. It is then unusual that in addition to dCMP deaminases, the eukaryote Dictyostelium discoideum has two dCTP deaminases (Dcd1Dicty and Dcd2Dicty). Expression of either DcdDicty can fully rescue the slow growth of an E. coli dcd knockout. Both DcdDicty mitigate the hydroxyurea sensitivity of a Schizosaccharomyces pombe dCMP deaminase knockout...
December 8, 2023: Molecular Biology and Evolution
#10
JOURNAL ARTICLE
SungA Bae, Wan Kee Kim, Seng Chan You, Minkwan Kim, In Hyun Jung
INTRODUCTION: Amlodipine, widely used as a first-line treatment for hypertension, has inconclusive clinical evidence regarding its efficacy in patients with heart failure. This retrospective cohort study aimed to investigate the clinical effectiveness of amlodipine treatment after hospitalization for heart failure in patients with dilated cardiomyopathy (DCMP). METHODS: A total of 20,851 patients who were diagnosed with DCMP and admitted for heart failure between 2005 and 2016 according to Korean nationwide medical insurance service database were enrolled...
2023: Frontiers in Cardiovascular Medicine
#11
JOURNAL ARTICLE
K P Kravchenko, D S Medvedev, S N Morozkina, D V Trotsyuk, S V Gornov, V O Polyakova
In recent years, more and more attention of researchers has been paid to the study of dilated cardiomyopathy (DCMP). The prevalence of this disease in older age groups is higher than previously thought, and the course of the disease is associated with a worse prognosis and treatment difficulties. Researchers are considering various signaling molecules whose expression changes are associated with myocardial damage and the development of DCMP; evaluation of changes in the expression of melatonin and its receptors in DCMP requires further study...
2023: Advances in Gerontology
#12
JOURNAL ARTICLE
Franz Huschner, Jagoda Głowacka-Walas, James D Mills, Katarzyna Klonowska, Kathryn Lasseter, John M Asara, Romina Moavero, Christoph Hertzberg, Bernhard Weschke, Kate Riney, Martha Feucht, Theresa Scholl, Pavel Krsek, Rima Nabbout, Anna C Jansen, Bořivoj Petrák, Jackelien van Scheppingen, Josef Zamecnik, Anand Iyer, Jasper J Anink, Angelika Mühlebner, Caroline Mijnsbergen, Lieven Lagae, Paolo Curatolo, Julita Borkowska, Krzysztof Sadowski, Dorota Domańska-Pakieła, Magdalena Blazejczyk, Floor E Jansen, Stef Janson, Malgorzata Urbanska, Aleksandra Tempes, Bart Janssen, Kamil Sijko, Konrad Wojdan, Sergiusz Jozwiak, Katarzyna Kotulska, Karola Lehmann, Eleonora Aronica, Jacek Jaworski, David J Kwiatkowski
We present a comprehensive multi-omic analysis of the EPISTOP prospective clinical trial of early intervention with vigabatrin for pre-symptomatic epilepsy treatment in Tuberous Sclerosis Complex (TSC), in which 93 infants with TSC were followed from birth to age 2 years, seeking biomarkers of epilepsy development. Vigabatrin had profound effects on many metabolites, increasing serum deoxycytidine monophosphate (dCMP) levels 52-fold. Most serum proteins and metabolites, and blood RNA species showed significant change with age...
November 23, 2023: Nature Communications
#13
JOURNAL ARTICLE
Anna Ligasová, Barbora Piskláková, David Friedecký, Karel Koberna
Deoxycytidine analogues (dCas) are widely used for the treatment of malignant diseases. They are commonly inactivated by cytidine deaminase (CDD), or by deoxycytidine monophosphate deaminase (dCMP deaminase). Additional metabolic pathways, such as phosphorylation, can substantially contribute to their (in)activation. Here, a new technique for the analysis of these pathways in cells is described. It is based on the use of 5-ethynyl 2'-deoxycytidine (EdC) and its conversion to 5-ethynyl 2'-deoxyuridine (EdU)...
November 22, 2023: Scientific Reports
#14
JOURNAL ARTICLE
David E DeMik, Jess H Lonner, Jason Cholewa, Michael B Anderson, Atul F Kamath, Krishna R Tripuraneni
BACKGROUND: Contemporary total knee arthroplasty (TKA) patients have increased expectations of returning to pre-disease function, including sexual activity (SA). The purpose of this study was to determine whether patients using a digital care management platform (DCMP) were more likely to have a higher rate and frequency of return to SA. METHODS: An exploratory analysis of a prospective, multi-center, randomized controlled trial enrolled patients undergoing TKA...
October 16, 2023: Journal of Arthroplasty
#15
JOURNAL ARTICLE
Yining Jiang, Carine Clavaguéra, Suvasthika Indrajith, Chantal Houée-Levin, Giel Berden, Jos Oomens, Scuderi Debora
OH●-induced oxidation products of DNA nucleosides and nucleotides have been structurally characterized by collision-induced dissociation tandem mass spectrometry (CID-MS2) and Infrared Multiple Photon Dissociation (IRMPD) spectroscopy. CID-MS2 results have shown that the addition of one oxygen atom occurs on the nucleobase moiety. The gas-phase geometries of +16 mass increment products of 2'-deoxyadenosine (dA(O)H+), 2'-deoxyadenosine 5'-monophosphate (dAMP(O)H+), 2'-deoxycytidine (dC(O)H+), and 2'-deoxycytidine 5'-monophosphate (dCMP(O)H+) are extensively investigated by IRMPD spectroscopy and quantum-chemical calculations...
September 15, 2023: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
#16
Izaac Sit, Eleanor Quirk, Eshani Hettiarachchi, Vicki H Grassian
No abstract text is available yet for this article.
July 28, 2023: Langmuir: the ACS Journal of Surfaces and Colloids
#17
JOURNAL ARTICLE
Izaac Sit, Mark A Young, James D Kubicki, Vicki H Grassian
Geochemical interfaces can impact the fate and transport of aqueous species in the environment including biomolecules. In this study, we investigate the surface chemistry of adsorbed nucleotides on two different minerals, hematite and goethite, using infrared spectroscopy and density functional theory (DFT) calculations. Attenuated total reflectance-Fourier transform infrared spectroscopy is used to probe the adsorption of deoxyadenosine monophosphate (dAMP), deoxyguanosine monophosphate (dGMP), deoxycytidine monophosphate (dCMP), and deoxythymidine monophosphate (dTMP) onto either hematite or goethite particle surfaces...
July 20, 2023: Physical Chemistry Chemical Physics: PCCP
#18
JOURNAL ARTICLE
Robyn Richie-Jannetta, Pradeep Pallan, Phillip J Kingsley, Nikhil Kamdar, Martin Egli, Lawrence J Marnett
The DNA adduct 6-oxo-M1 dG, (3-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-oxo-pyrimido(1,2alpha)purin-10(3H)-one) is formed in the genome via oxidation of the peroxidation-derived adduct M1 dG. However, the effect of 6-oxo-M1 dG adducts on subsequent DNA replication is unclear. Here we investigated the ability of the human Y-family polymerase hPol η to bypass 6-oxo-M1 dG. Using steady-state kinetics and analysis of DNA extension products by LC-MS/MS, we found hPol η preferentially inserts a dAMP or dGMP nucleotide into primer-templates across from the 6-oxo-M1 dG adduct, with dGMP being slightly preferred...
July 17, 2023: Journal of Biological Chemistry
#19
Josef Finsterer, Gerhard Pölzl
Mutations in the LMNA gene cause heterogeneous phenotypes such as myopathy, progeroid syndromes, hereditary neuropathies, cardiomyopathies, or lipodystrophies. A specific LMNA mutation manifesting as dilated cardiomyopathy (dCMP), and iron metabolism disorder has not been reported. The patient is a 50-year-old female with palpitations and fatigue since childhood, hyperlipidemia for 25 years, gastroesophageal reflux for 20 years, arterial hypertension for eight years, and iron deficiency for one year, requiring intravenous iron supplementation...
May 2023: Curēus
#20
JOURNAL ARTICLE
Xiao Jia, Xiaohang Lin, Yang Liu, Yuanyuan Qu, Mingwen Zhao, Xiangdong Liu, Weifeng Li
Electrokinetic identification of biomolecules is an effective analytical method in which an electric field drives the nucleic acids, peptides, and other species through a nanoscale channel and the time of flight (TOF) is recorded. The mobilities of the molecules are determined by the water/nanochannel interface, including the electrostatic interactions, surface roughness, van der Waals interactions, and hydrogen bonding. The recently reported α-phase phosphorus carbide (α-PC) has an intrinsically wrinkled structure that can efficiently regulate the migrations of biomacromolecules on it, making it a highly promising candidate for the fabrication of nanofluidic devices for electrophoretic detection...
May 17, 2023: Journal of Materials Chemistry. B, Materials for Biology and Medicine
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