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SLE and dsDNA

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https://www.readbyqxmd.com/read/29770567/association-between-polymorphisms-in-the-promoter-region-of-mir-17-92-cluster-and-systemic-lupus-erythematosus-in-a-chinese-population
#1
Rong Wang, Chun-Fang Wang, Hai-Mei Qin, Yu-Lan Lu, Gui-Jiang Wei, Hua-Tuo Huang, Yang Xiang, Jun-Li Wang, Yan Lan, Ye-Sheng Wei
The aim of this study was to investigate the association of genetic polymorphisms in the promoter region of miR-17-92 with systemic lupus erythematosus (SLE). The gene polymorphism was analysed using SNaPshot in 312 SLE patients and 396 controls. Relative expression of miR-17-92 was measured by quantitative real-time PCR. Association was found between rs9515692 and a decreased risk of SLE (CT vs CC: OR = 0.65, 95%CI, 0.46-0.92, P = .014; CT+TT vs CC: OR = 0.64, 95%CI, 0.46-0.90, P = .009; T vs C: OR = 0.69, 95%CI, 0...
May 16, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29759049/klinefelter-s-syndrome-with-lupus-encephalitis-and-retroperitoneal-teratoma
#2
C Ng Wq, S E Eide, Huang J, Khor Ym
We report a case of a middle-aged male who presented with pyrexia of unknown origin, oral ulcers, rash and bicytopenia. His past medical history included unexplained proteinuria, infertility and joint pain. Initial workup showed a large retroperitoneal soft tissue mass, which has appeared stable for 10 years. He subsequently developed neuropsychiatric symptoms with imaging findings of meningoencephalitis. Concurrent investigations showed elevated ANA, anti-double-stranded DNA (dsDNA) and ESR levels, as well as low complement levels...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29747124/serum-human-epididymis-protein-4-is-a-predictor-for-developing-nephritis-in-patients-with-systemic-lupus-erythematosus-a-prospective-cohort-study
#3
Yingpeng Ren, Jing Xie, Feng Lin, Wanwan Luo, Zhencheng Zhang, Panying Mao, Renqian Zhong, Yan Liang, Zaixing Yang
BACKGROUND: It has been demonstrated that serum human epididymis protein 4 (HE4) is a useful biomarker for differentiating lupus nephritis (LN) from systemic lupus erythematosus (SLE). However, it remains unclear whether HE4 can be used to predict the development of LN. METHODS: A total of 74 SLE patients without LN were recruited between August 2008 and September 2013. Serum HE4 concentrations were measured by enzyme-linked immunosorbent assay. These patients were followed up from the date of SLE diagnosis to LN development or the end of the study...
May 7, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29737056/-correlation-of-thyroid-autoantibodies-system-lupus-erythematosus-immunologic-indicators-and-disease-activity-in-sle-with-ht
#4
Huan Liu, Li-Hua Yang, Geng Yin, Qi-Bing Xie
OBJECTIVE: To investigate the correlation of disease activity and thyroid indicators ,immunologic markers of system lupus erythematosus (SLE) in SLE with Hashimoto's thyroiditis (HT). METHODS: The clinical data of 63 cases of SLE with HT were collected. According to Systemic lupus erythematosus disease activity index 2000 (SLEDAI-2000),we classified the patients into four groups,which were remission group (5 cases),low (19 cases),moderate (12 cases) and high (27 cases) disease activity group...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29731498/a-case-of-anti-glomerular-basement-membrane-antibody-positive-systemic-lupus-erythematosus-with-pulmonary-hemorrhage-successfully-treated-at-an-early-stage-of-the-disease
#5
Takehisa Yamada, Koji Mugishima, Seiichiro Higo, Yukie Yoshida, Fumiaki Itagaki, Shizuka Yui, Tetsuya Kashiwagi, Yoko Endo, Akira Shimizu, Shuichi Tsuruoka
We report here a case of systemic lupus erythematosus (SLE) with pulmonary hemorrhage and anti-glomerular basement membrane (anti-GBM) antibodies. A 42-year-old woman was admitted to our hospital with complaints of exanthema, arthralgia, shortness of breath, and hemoptysis. Plain chest computed tomography (CT) scan revealed pericardial effusion, bilateral pleural effusions, and pulmonary hemorrhage. Laboratory findings on admission revealed proteinuria, microscopic hematuria, anemia, leukopenia, hypoalbuminemia, hypocomplementemia, and slightly elevated levels of serum creatinine...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29728857/cxcl13-is-an-activity-marker-for-systemic-but-not-cutaneous-lupus-erythematosus-a-longitudinal-cohort-study
#6
Anna Niederkorn, Julia Frühauf, Gerold Schwantzer, Nora Wutte, Clemens Painsi, Stefan Werner, Martin Stradner, Andrea Berghold, Josef Hermann, Elisabeth Aberer
Serum levels of the IFN-regulated cytokine CXCL13 have been found to correlate with SLEDAI and renal involvement in systemic lupus erythematosus. This study investigates whether CXCL13 can also be a marker of disease activity in patients with subacute cutaneous or chronic cutaneous lupus erythematosus (SCLE, CCLE). We analysed CXCL13 levels in 60 patients' sera (18 SLE, 19 SCLE, 23 CCLE) at five time points within 1 year and correlated these levels with disease activity scores and laboratory markers. Clinical scores with no/mild, moderate or high/severe disease activity were categorized by SLEDAI in SLE, by CLASI in SCLE/CCLE...
May 4, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29721697/spectrum-of-systemic-lupus-erythematosus-in-oman-from-childhood-to-adulthood
#7
Asma Al Rasbi, Eiman Abdalla, Rabab Sultan, Nasreen Abdullah, Juma Al Kaabi, Ibrahim Al-Zakwani, Reem Abdwani
SLE is a disease that mainly affects women of childbearing age, however, a total of 15-20% of cases present in children. Although adult onset SLE (aSLE) and childhood onset SLE (cSLE) share the same diagnostic criteria, differences have been identified. The aim of this study is to compare the similarities and differences in between cSLE and aSLE in an Arab population from Oman. We evaluated 225 SLE patients, 139 adults and 86 children, who fulfilled the criteria for diagnosis. At disease onset, 99% of SLE cohort fulfilled the SLICC criteria; however the ACR 1997 criteria were fulfilled in 66% aSLE and 80% cSLE...
May 2, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29702988/enteritis-as-initial-manifestation-of-systemic-lupus-erythematosus-in-early-pregnancy-a-case-report
#8
Anna Maria Bellou, Dominik Bös, Guido Kukuk, Ulrich Gembruch, Waltraut Maria Merz
RATIONAL: Lupus enteritis is a rare, severe complication of systemic lupus erythematosus (SLE). We report of a patient who presented with enteritis as manifestation of new-onset SLE during the first trimester of pregnancy. PATIENTS CONCERNS: The 23-year nulliparous patient was admitted to a district hospital with abdominal pain, nausea, vomiting and bloody diarrhea at a gestational age (GA) of 10 weeks. Her symptoms improved with symptomatic treatment and she was discharged a few days later...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29698559/tuftsin-phosphorylcholine-tpc-equally-effective-to-methylprednisolone-in-ameliorating-lupus-nephritis-in-a-mice-model
#9
Asaf Shemer, Shay Kivity, Ora Shovman, Ori Perry, Abdulla Watad, Dana Ben-Ami Shor, Alex Volkov, Iris Barshack, Nicola L Bragazzi, Alexander Krule, Mati Fridkin, Howard Amital, Miri Blank, Yehuda Shoenfeld
BACKGROUND: The role of helminth treatment in autoimmune diseases is constantly growing. Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with challenging treatment options. Tuftsin phosphorylcholine (TPC) is a novel helminth-based compound that modulates the host immune network. OBJECTIVES: This study was conducted to evaluate the potential value of TPC in ameliorating lupus nephritis in a murine model and specifically to compare the efficacy of TPC to the existing first-line therapy for SLE: corticosteroids (methylprednisolone)...
April 26, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29688144/prevalence-risk-factors-and-impact-on-mortality-of-neuropsychiatric-lupus-a-prospective-single-center-study
#10
G Y Ahn, D Kim, S Won, S T Song, H-J Jeong, I-W Sohn, S Lee, Y B Joo, S-C Bae
Objective The objective of this paper is to identify the prevalence, risk factors, and impact on mortality of neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Patients from the Hanyang BAE lupus cohort were registered and followed from 1998 to 2015. NPSLE was defined using American College of Rheumatology (ACR) case definitions and Ainiala criteria. Demographics, autoantibodies, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and Systemic Lupus International Collaborating Clinic (SLICC)/ACR Damage Index were collected at baseline and then annually...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29671280/efficacy-and-safety-of-subcutaneous-belimumab-in-anti-dsdna-positive-hypocomplementemic-patients-with-systemic-lupus-erythematosus
#11
A Doria, W Stohl, A Schwarting, M Okada, M Scheinberg, R van Vollenhoven, A E Hammer, J Groark, D Bass, N L Fox, D Roth, D Gordon
OBJECTIVE: To investigate the efficacy and safety of belimumab, a human immunoglobulin monoclonal antibody against B lymphocyte stimulator, in a subset of patients with systemic lupus erythematosus (SLE) who were hypocomplementemic (C3 [<90 mg/dL] and/or C4 [<10 mg/dL]) and anti-double-stranded(ds)DNA-positive (≥30 IU/mL) at baseline. METHODS: This Phase III, double-blind, placebo-controlled study (BEL112341; NCT01484496) randomized patients (2:1) with moderate-to-severe SLE (Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity Index ≥8) to weekly subcutaneous (SC) belimumab 200 mg or placebo, plus standard SLE therapy, for 52 weeks...
April 18, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29668584/combined-utilization-of-untimed-single-urine-of-mcp-1-and-tweak-as-a-potential-indicator-for-proteinuria-in-lupus-nephritis-a-case-control-study
#12
Xiwen Dong, Zhaohui Zheng, Xing Luo, Jin Ding, Ying Li, Zhiqin Li, Sijia Li, Mengyao Rong, Yalu Fu, Zhenbiao Wu, Ping Zhu
The aim of this study was to determine whether combined utilization of untimed single urine monocyte chemoattractant protein 1 (uMCP-1) and tumor necrosis factor (TNF)-like weak inducer of apoptosis (uTWEAK) could serve as a screening test for proteinuria in patients with lupus nephritis (LN).A case-control study that contained 39 biopsy-proven LN patients, 20 non-LN systemic lupus erythematosus (SLE) patients, and 10 healthy controls (HCs) were carried out. Correlations between uMCP-1, uTWEAK, and traditional clinical markers were analyzed by Spearman correlation test...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29657153/repeat-testing-of-antibodies-and-complements-in-systemic-lupus-erythematosus-when-is-it-enough
#13
Thomas C Raissi, Carly Hewson, Janet E Pope
OBJECTIVE: Patients with systemic lupus erythematosus (SLE) frequently undergo repeat testing for antibodies against extractable nuclear antigens (anti-ENA), but it is not known whether this is necessary or cost-effective. This study characterized the frequencies of changes in anti-ENA, anti-dsDNA, and complement C3 and C4 upon repeat testing. METHODS: Chart review was done at one site of 130 patients with SLE enrolled in the 1000 Canadian Faces of Lupus prospective registry with annual antibody and complement testing...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29657143/clinical-and-serological-associations-with-the-development-of-incident-proteinuria-in-danish-patients-with-systemic-lupus-erythematosus
#14
Nima Tanha, Renata Baronaite Hansen, Christoffer Tandrup Nielsen, Mikkel Faurschou, Søren Jacobsen
OBJECTIVE: In a longitudinal cohort study, we investigated whether clinical and serological manifestations at the time of classification of systemic lupus erythematosus (SLE) were predictive of subsequent development of incident proteinuria as a biomarker of incident lupus nephritis. METHODS: Patients fulfilling SLE classification criteria but having no proteinuria prior to or at the time of classification were included. Data on SLE manifestations, vital status, criteria-related autoantibodies, and SLE-associated medications were collected during clinical visits and supplemented by chart review...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29656375/does-erythrocyte-sedimentation-rate-reflect-and-discriminate-flare-from-infection-in-systemic-lupus-erythematosus-correlation-with-clinical-and-laboratory-parameters-of-disease-activity
#15
Valentin Sebastian Schäfer, Katharina Weiß, Andreas Krause, Wolfgang Andreas Schmidt
To examine disease activity parameters in patients with systemic lupus erythematosus (SLE) experiencing flare, infection, both, or neither condition, focusing on erythrocyte sedimentation rate (ESR). This study is a retrospective analysis of 371 consecutive inpatient SLE cases from 2006 to 2015. Cases were classified as flare (n = 147), infection (n = 48), both (n = 23), or neither (n = 135). ESR levels were correlated to C-reactive protein (CRP), ferritin, anti-dsDNA antibodies, complement C3 reduction, serositis, and erythrocyturia with proteinuria (Pearson's correlation)...
April 14, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29648686/development-and-validation-of-a-novel-evidence-based-lupus-multivariable-outcome-score-for-clinical-trials
#16
Michal Abrahamowicz, John M Esdaile, Rosalind Ramsey-Goldman, Lee S Simon, Vibeke Strand, Peter E Lipsky
BACKGROUND: Trials of new SLE treatments are hampered by the lack of effective outcome measures. To address this, we developed a new Lupus Multivariable Lupus Outcome Score (LuMOS). METHOD: The LuMOS formula was developed by analyzing raw data of two pivotal trials: BLISS-52 and BLISS-76, the basis for approval of belimumab (Bel). Using data from BLISS-76 as the learning dataset, we optimized discrimination between outcomes for patients treated with 10mg/kg Bel versus placebo over the first 52 weeks of follow-up using multivariable logistic regression analyses...
April 12, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29629666/clinical-significance-of-anti-ribosomal-p-protein-antibodies-in-patients-with-lupus-nephritis
#17
Sabahat Sarfaraz, Sabiha Anis, Ejaz Ahmed, Rana Muzaffar
BACKGROUND: Systemic lupus erythematosus (SLE) is achronic inflammatory disorder affecting multiplesystems of the body. Clinical features show wide variations in patients with different ethnic background. Renal involvement is a predictor of poor prognosis. Immunological workup is an integral part of SLE diagnostic criteria. Anti-ribosomal P Protein (anti-P) antibodies are highly specific for SLE. They may be present inantinuclear antibodies (ANA) negative SLE patients. Their role in lupus nephritis (LN) is under debate, some researchers found them associated with poor prognosiswhereasothers found favorable effect of these antibodies on renal disease...
April 9, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29623613/analytical-variability-in-the-determination-of-anti-double-stranded-dna-antibodies-the-strong-need-of-a-better-definition-of-the-old-and-new-tests
#18
Maria Infantino, M Manfredi, M Merone, V Grossi, M Benucci, F Li Gobbi, F Bandinelli, A Damiani, P Soda
Anti-dsDNA antibodies are a heterogeneous group of antibodies, quite specific for SLE. Their variability is related to the assay used, the immunoglobulin class secondary antibody, and the dsDNA source. The standardization of measuring anti-dsDNA antibodies is still poor and different methods yield different results. Several novel technologies were developed during the last decades that represent viable alternatives to the traditional methods such as the chemiluminescent immunoassay (CIA) and multiplex flow immunoassay (MFI)...
April 5, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29608758/neutrophil-extracellular-trap-release-is-associated-with-antinuclear-antibodies-in-systemic-lupus-erythematosus-and-anti-phospholipid-syndrome
#19
Maarten van der Linden, Lucas L van den Hoogen, Geertje H A Westerlaken, Ruth D E Fritsch-Stork, Joël A G van Roon, Timothy R D J Radstake, Linde Meyaard
Objectives: Increased release of neutrophil extracellular traps (NETs) is implicated in the activation of plasmacytoid dendritic cells, vascular disease and thrombosis in SLE and APS. However, studies comparing NET release between patients with SLE and APS are lacking. Here we evaluated plasma-induced NET release in a large cohort of patients with SLE, SLE + APS and primary APS in relation to clinical and serological parameters. Methods: Neutrophils from healthy controls were exposed to plasma of heterologous healthy controls (n = 27) or SLE (n = 55), SLE + APS (n = 38) or primary APS (PAPS) (n = 28) patients and NET release was quantified by immunofluorescence...
March 28, 2018: Rheumatology
https://www.readbyqxmd.com/read/29576246/autoantibodies-targeting-tlr-and-smad-pathways-define-new-subgroups-in-systemic-lupus-erythematosus
#20
Myles J Lewis, Michael B McAndrew, Colin Wheeler, Nicholas Workman, Pooja Agashe, Jens Koopmann, Ezam Uddin, David L Morris, Lu Zou, Richard Stark, John Anson, Andrew P Cope, Timothy J Vyse
OBJECTIVES: The molecular targets of the vast majority of autoantibodies in systemic lupus erythematosus (SLE) are unknown. We set out to identify novel autoantibodies in SLE to improve diagnosis and identify subgroups of SLE individuals. METHODS: A baculovirus-insect cell expression system was used to create an advanced protein microarray with 1543 full-length human proteins expressed with a biotin carboxyl carrier protein (BCCP) folding tag, to enrich for correctly folded proteins...
March 22, 2018: Journal of Autoimmunity
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