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https://www.readbyqxmd.com/read/29730982/phytosterol-determination-in-lipid-emulsions-for-parenteral-nutrition
#1
Josep M Llop Talaverón, Ana Novak, Josep M Suñé Negre, María Badia Tahull, Elisabet Leiva Badosa, Josep R Ticó Grau
OBJECTIVE: The presence of phytosterols in vegetal lipid emulsions has been  associated with alterations of liver function tests. Determination of phytosterols  content, currently undeclared, would allow the development of strategies to  prevent or treat these alterations. METHOD: 3-4 non-consecutive batches of 6 lipid emulsions from different providers (Clinoleic, Intralipid, Lipofundina, Lipoplus, Omegaven and Smoflipid) were analyzed. Differences in total phytosterol assay between providers and batches were statistically studied by a one-way ANOVA and Kruskal-Wallis non-parametric approximation and post hoc Scheffé test (p < 0...
May 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29565143/the-presence-of-inorganic-calcium-in-pediatric-parenteral-admixtures
#2
Dorota Watrobska-Swietlikowska, Agnieszka Szlagatys-Sidorkiewicz, Ronan MacLoughlin
INTRODUCTION: Newborn infants and small children require large amounts of calcium and phosphate in a low volume of solution which can increase the risk of precipitation of calcium phosphate. Calcium gluconate is the predominant calcium salt form employed in parenteral nutrition (PN) compounding due to its solubility profile with phosphate. Unfortunately, calcium gluconate contains higher levels of aluminum contamination than calcium chloride, resulting in an increased potential for aluminum toxicity in patients receiving traditional PN...
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29534288/parenteral-lipid-dose-restriction-with-soy-oil-not-fish-oil-preserves-retinal-function-in-neonatal-piglets
#3
Marihan Lansing, Yves Sauvé, Ioannis Dimopoulos, Catherine J Field, Miyoung Suh, Pamela Wizzard, Susan Goruk, David Lim, Mitsuru Muto, Paul Wales, Justine Turner
BACKGROUND: A dietary supply of docosahexaenoic acid (DHA) and arachidonic acid (AA) is critical for neonatal retinal development. Both are absent/minimal in parenteral nutrition (PN) using soy-oil emulsions ([SO] Intralipid®) traditionally used for neonatal intestinal failure. In contrast, fish-oil emulsions ([FO] Omegaven®) are enriched in DHA/AA. The aim of this study was to compare retinal function and fatty acid content in neonatal piglets fed PN with SO or FO. METHODS: Two-5-day-old piglets were randomly allocated to SO (n = 4) or FO (n = 4), provided at equivalent doses (5g/kg/d)...
March 13, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29378575/effects-of-omegaven%C3%A2-epa-dha-and-oxaliplatin-on-oesophageal-adenocarcinoma-cell-lines-growth-cytokine-and-cell-signal-biomarkers-expression
#4
Amar M Eltweri, Lynne M Howells, Anne L Thomas, Ashley R Dennison, David J Bowrey
BACKGROUND: There is limited evidence assessing the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oesophageal adenocarcinoma, both in vitro and in vivo. We evaluated the effects of the omega-3 PUFA and oxaliplatin on OE33 and OE19 cells. METHOD: The two oesophageal cells were treated with Omegaven® (fish oil emulsion), EPA, DHA and oxaliplatin and incubated for up to 144 h. RESULTS: The following inhibitory effects were observed on OE33 cells: EPA reduced cell growth by 39% (p = 0...
January 30, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29358007/pretreatment-with-intravenous-fish-oil-reduces-hepatic-ischemia-reperfusion-injury-in-a-murine-model
#5
Meredith A Baker, Prathima Nandivada, Paul D Mitchell, Gillian L Fell, Amy Pan, Lorenzo Anez-Bustillos, Duy T Dao, Kathleen M Gura, Vania Nosé, Mark Puder
BACKGROUND: Ischemia reperfusion injury is a barrier to liver surgery and transplantation, particularly for steatotic livers. The purpose of this study was to determine if pretreatment with a single dose of intravenous fish oil decreases hepatic ischemia reperfusion injury and improves recovery of injured livers. METHODS: Sixty adult male C57BL/6 mice received 1 g/kg intravenous fish oil (Omegaven, Fresenius Kabi) or isovolumetric 0.9% NaCl (saline) via tail vein 1 hour before 30 minutes of 70% hepatic ischemia...
January 19, 2018: Surgery
https://www.readbyqxmd.com/read/29079315/a-comparison-of-lipid-minimization-strategies-in-children-with-intestinal-failure
#6
Jessica Gonzalez-Hernandez, Purvi Prajapati, Gerald Ogola, Van Nguyen, Nandini Channabasappa, Hannah G Piper
PURPOSE: The purpose of this study was to compare outcomes of lipid minimization with either Intralipid (IL) or Omegaven® in children with intestinal failure (IF) who developed intestinal failure-associated liver disease (IFALD) while receiving parenteral nutrition (PN). METHODS: A retrospective review of children with IF requiring PN who developed IFALD (direct bilirubin >2 mg/dL) while receiving IL (2009-2016) was performed. Clinical characteristics, nutritional, and laboratory values were compared between children treated with reduced IL or Omegaven®...
October 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28767202/effects-of-parenteral-fish-oil-on-plasma-nonesterified-fatty-acids-and-systemic-inflammatory-mediators-in-dogs-following-ovariohysterectomy
#7
Kaoru Tsuruta, Robert C Backus, Amy E DeClue, Kevin L Fritsche, Fred A Mann
OBJECTIVE: To evaluate the effects of intravenous (IV) infusion of fish oil (FO) emulsion following ovariohysterectomy (OVH) on inflammatory mediators and plasma omega-3 nonesterified fatty acids (NEFA) concentrations in dogs. DESIGN: Prospective clinical study. SETTING: University teaching hospital. ANIMALS: Twenty-nine privately owned dogs undergoing routine OVH. INTERVENTIONS: Postoperative 3-hour IV infusion of saline (n = 9), FO (Omegaven, n = 10), or soybean oil (SO, intralipid, n = 10) emulsion and blood collected before, 5 and 24 hours following OVH for plasma NEFA and RBC membrane fatty acids (FAs) concentrations, leukocyte cytokine production capacity, and C-reactive protein (CRP) measurement...
September 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28606477/n-3-polyunsaturated-fatty-acid-enriched-lipid-emulsion-improves-paneth-cell-function-via-the-il-22-stat3-pathway-in-a-mouse-model-of-total-parenteral-nutrition
#8
Jiwei Wang, Feng Tian, Huijun Zheng, Hao Tian, Peng Wang, Li Zhang, Xuejin Gao, Xinying Wang
Total parenteral nutrition (TPN) is a life-saving therapy for patients with gastrointestinal dysfunction or failure. Long-term TPN impairs gut barrier function and contributes to infections and poor clinical outcomes. However, the underlying mechanisms of TPN-related gut barrier damage have not been fully elucidated, and effective measures are still rare. Here, we compared the effects of a predominantly n-6 polyunsaturated fatty acids emulsion (PUFAs; Intralipid) and a lipid emulsion containing n-3 PUFAs (Intralipid plus Omegaven) on antimicrobial peptides produced by Paneth cells...
August 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28433363/the-molecular-impact-of-omega-3-fatty-acids-on-hepatic-pro-inflammatory-cytokine-signaling
#9
George J Ventro, Yingkui Yang, Min Chen, Carroll M Harmon
PURPOSE: Parenteral nutrition associated liver disease (PNALD) develops in a subset of children receiving parenteral nutrition for intestinal failure. Omegaven™ is an omega-3 fatty acid (Ω3FA) lipid emulsion high in docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) that can lessen PNALD. Inflammatory cytokines (IL-1, TNF-α, TGF-β) are elevated in PNALD and can decrease paraoxonase 1 protein expression (PON1). We sought to determine the effect of Omegaven™, EPA, and DHA on inflammatory cytokines TNF-α, IL-1, and TGF-β via ERK1/2 and p-Smad2/3 signaling pathways as well as the changes in intracellular PON1 protein expression as a potential mechanism explaining the protective effects of Omegaven™ and Ω3FA...
June 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28401057/intestinal-hypoganglionosis-leading-to-intestinal-failure-and-the-compassionate-use-of-omegaven%C3%A2
#10
Racha Khalaf, Sara Karjoo, Paul Danielson, Michael Wilsey, Fauzia Shakeel
Intestinal hypoganglionosis is a rare innervation disorder that provides numerous nutritional, medical and surgical challenges. In this case report, we present a case of a newborn with intestinal hypoganglionosis leading to intestinal failure and intestinal failure-associated liver disease who responded to Omegaven™, a fat emulsion comprised of omega-3 fatty acids. Omegaven™ has been shown to be beneficial in the management of cholestatic liver injury. Clinical success with Omegaven™ was seen in this patient with a clear decrease in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and complete resolution of cholestasis with a direct bilirubin of zero within two weeks of initiation of Omegaven™...
March 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28162861/effect-of-omegaven-on-mast-cell-concentration-in-diabetic-wound-healing
#11
Saeid Babaei, Hadi Ansarihadipour, Mahmoodreza Nakhaei, Mohammadreza Darabi, Parvindokht Bayat, Mohammadhassan Sakhaei, Maryam Baazm, Atefe Mohammadhoseiny
Diabetic wound healing is a complicated process. In all over the world 15% of 200 million diabetic people suffer from diabetic foot problems. Mast cells are known to participate in three phases of wound healing: the inflammatory reaction, angiogenesis and extracellular-matrix reabsorption. The inflammatory reaction is mediated by released histamine and arachidonic acid metabolites. Omega-3 fatty acids alter proinflammatory cytokine production during wound healing which affects the presence of inflammatory cells in wound area as well, but how this events specifically influences the presence of mast cells in wound healing is not clearly understood...
May 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/27904853/effects-of-postoperative-parenteral-nutrition-with-different-lipid-emulsions-in-patients-undergoing-major-abdominal-surgery
#12
Seher Demirer, Ali Sapmaz, Ahmet Serdar Karaca, Ilknur Kepenekci, Semih Aydintug, Deniz Balci, Pinar Sonyurek, Kenan Kose
PURPOSE: This study was designed to investigate the effects of total parenteral nutrition (PN) using different lipid emulsions in patients undergoing major abdominal surgery. METHODS: Fifty-two patients were randomized to receive soybean oil + medium chain triglycerides (MCT) (group I), soybean oil + olive oil (group II), soybean oil + olive oil + fish oil (group III) as a lipid source. PN was started on postoperative day 1 and patients were maintained on PN for a minimum period of 4 days...
December 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27902774/intravenous-treatment-with-a-long-chain-omega-3-lipid-emulsion-provides-neuroprotection-in-a-murine-model-of-ischemic-stroke-a-pilot-study
#13
Dirk Berressem, Konrad Koch, Nicole Franke, Jochen Klein, Gunter P Eckert
Single long-chain omega-3 fatty acids (e.g. docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA)) are known for their neuroprotective properties associated with ischemic stroke. This pilot study aimed to test the effectiveness of an acute treatment with a long-chain omega-3 lipid emulsion (Omegaven 10%®, OGV) that contains fish oil (DHA 18 mg/ml; EPA 21 mg/ml) and α-tocopherol (0.2 mg/ml) in a transient middle cerebral artery occlusion (MCAO) model of ischemic stroke in mice. For this purpose, female CD-1 mice were anesthetized and subjected to 90 minutes of MCAO...
2016: PloS One
https://www.readbyqxmd.com/read/27614675/n-3-fatty-acid-based-parenteral-nutrition-improves-postoperative-recovery-for-cirrhotic-patients-with-liver-cancer-a-randomized-controlled-clinical-trial
#14
Binhao Zhang, Gang Wei, Rui Li, Yanjun Wang, Jie Yu, Rui Wang, Hua Xiao, Chao Wu, Chao Leng, Bixiang Zhang, Xiao-Ping Chen
BACKGROUND & AIMS: A new lipid emulsion enriched in n-3 fatty acid has been reported to prevent hepatic inflammation in patients following major surgery. However, the role of n-3 fatty acid-based parenteral nutrition for postoperative patients with cirrhosis-related liver cancer is unclear. We investigated the safety and efficacy of n-3 fatty acid-based parenteral nutrition for cirrhotic patients with liver cancer followed hepatectomy. METHODS: A prospective randomized controlled clinical trial (Registered under ClinicalTrials...
October 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27474222/multi-omic-profiles-of-hepatic-metabolism-in-tpn-fed-preterm-pigs-administered-new-generation-lipid-emulsions
#15
Gregory Guthrie, Madhulika Kulkarni, Hester Vlaardingerbroek, Barbara Stoll, Kenneth Ng, Camilia Martin, John Belmont, Darryl Hadsell, William Heird, Christopher B Newgard, Oluyinka Olutoye, Johannes van Goudoever, Charlotte Lauridsen, Xingxuan He, Edward H Schuchman, Douglas Burrin
We aimed to characterize the lipidomic, metabolomic, and transcriptomic profiles in preterm piglets administered enteral (ENT) formula or three parenteral lipid emulsions [parenteral nutrition (PN)], Intralipid (IL), Omegaven (OV), or SMOFlipid (SL), for 14 days. Piglets in all parenteral lipid groups showed differential organ growth versus ENT piglets; whole body growth rate was lowest in IL piglets, yet there were no differences in either energy expenditure or (13)C-palmitate oxidation. Plasma homeostatic model assessment of insulin resistance demonstrated insulin resistance in IL, but not OV or SL, compared with ENT...
September 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27342748/plasma-and-erythrocyte-uptake-of-omega-3-fatty-acids-from-an-intravenous-fish-oil-based-lipid-emulsion-in-patients-with-advanced-oesophagogastric-cancer
#16
A M Eltweri, A L Thomas, H L Fisk, A Arshad, P C Calder, A R Dennison, D J Bowrey
BACKGROUND: It has been demonstrated that short term intravenous (IV) administration of omega-3 polyunsaturated fatty acids (PUFAs) is more effective than oral supplementation at promoting incorporation of the bioactive omega-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into plasma, blood cells and tissues. The effect of repeated short term IV infusion of omega-3 PUFAs was investigated in patients with advanced oesophagogastric cancer during palliative chemotherapy...
June 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27322311/effectiveness-of-%C3%AF-3-polyunsaturated-fatty-acids-based-lipid-emulsions-for-treatment-of-patients-after-hepatectomy-a-prospective-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Yuanfeng Gong, Zhaohui Liu, Yadi Liao, Cong Mai, Tiejun Chen, Hui Tang, Yunqiang Tang
OBJECTIVE: The present study aimed to investigate the effectiveness of parenteral nutritional support with ω-3 PUFAs-based lipid emulsions in patients after liver resection. METHODS: A total of 119 patients were randomly assigned to the immunonutrition (IM) group (n = 59) and control group (n = 60). The IM group was continuously given Omegaven(®) 10% 100 mL/day rather than regular nutrition for five days postoperatively. Venous blood samples were obtained from all subjects before surgery and D1, D3 and D7 after surgery...
June 17, 2016: Nutrients
https://www.readbyqxmd.com/read/27143651/improvement-in-parenteral-nutrition-associated-cholestasis-with-the-use-of-omegaven-in-an-infant-with-short-bowel-syndrome
#18
Brian J Strang, Bruce A Reddix, Robert A Wolk
BACKGROUND: Parenteral nutrition-associated cholestasis (PNAC) and liver disease have been associated with soybean oil-based intravenous fat emulsions (IVFEs). The benefit of fish oil-based IVFEs in the reversal of parenteral nutrition (PN)-associated liver damage includes allowing for longer PN duration without immediate need for bowel or liver transplantation. METHODS: The present case involves an infant born with short bowel syndrome (SBS) requiring long-term PN with development of PNAC and subsequent administration of a fish oil-based IVFE...
October 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27072665/molecular-impact-of-omega-3-fatty-acids-on-lipopolysaccharide-mediated-liver-damage
#19
George Ventro, Min Chen, Yingkui Yang, Carroll M Harmon
BACKGROUND: Growing evidence suggests that omega 3 fatty acid containing lipid emulsions have a beneficial effect on parenteral nutrition associated liver disease (PNALD). However, the cellular and molecular mechanisms responsible for this effect are unclear. In this study, we investigated whether Omegaven™ fish oil emulsion could inhibit lipopolysaccharidase (LPS) mediated liver damage. METHODS: We examined the effects of Omegaven™ and LPS alone and synergistically on hepatic paraoxonase 1 (PON1), a potent antioxidant protein, ERK1/2 activity, and TLR4 regulation...
June 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26268565/-a-randomized-double-blind-study-of-the-effects-of-omega-3-fatty-acids-omegaven-on-outcome-after-major-liver-resection
#20
RANDOMIZED CONTROLLED TRIAL
Michael Linecker, Perparim Limani, Florin Botea, Irinel Popescu, Ruslan Alikhanov, Michail Efanov, Pavel Kim, Igor Khatkov, Dimitri Aristotele Raptis, Christoph Tschuor, Beatrice Beck-Schimmer, John Bonvini, Andrea Wirsching, Philipp Kron, Ksenija Slankamenac, Bostjan Humar, Rolf Graf, Henrik Petrowsky, Pierre-Alain Clavien
BACKGROUND: The body is dependent on the exogenous supply of omega-3 polyunsaturated fatty acids (n3-PUFA). These essential fatty acids are key players in regulating metabolic signaling but also exert anti-inflammatory and anti-carcinogenic properties. The liver is a major metabolic organ involved in fatty acid metabolism. Under experimental conditions, n3-PUFA exert beneficial effect on hepatic steatosis, regeneration and inflammatory insults such as ischemic injury after surgery. Some of these effects have also been observed in human subjects...
August 14, 2015: BMC Gastroenterology
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