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https://www.readbyqxmd.com/read/27904853/effects-of-postoperative-parenteral-nutrition-with-different-lipid-emulsions-in-patients-undergoing-major-abdominal-surgery
#1
Seher Demirer, Ali Sapmaz, Ahmet Serdar Karaca, Ilknur Kepenekci, Semih Aydintug, Deniz Balci, Pinar Sonyurek, Kenan Kose
PURPOSE: This study was designed to investigate the effects of total parenteral nutrition (PN) using different lipid emulsions in patients undergoing major abdominal surgery. METHODS: Fifty-two patients were randomized to receive soybean oil + medium chain triglycerides (MCT) (group I), soybean oil + olive oil (group II), soybean oil + olive oil + fish oil (group III) as a lipid source. PN was started on postoperative day 1 and patients were maintained on PN for a minimum period of 4 days...
December 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27902774/intravenous-treatment-with-a-long-chain-omega-3-lipid-emulsion-provides-neuroprotection-in-a-murine-model-of-ischemic-stroke-a-pilot-study
#2
Dirk Berressem, Konrad Koch, Nicole Franke, Jochen Klein, Gunter P Eckert
Single long-chain omega-3 fatty acids (e.g. docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA)) are known for their neuroprotective properties associated with ischemic stroke. This pilot study aimed to test the effectiveness of an acute treatment with a long-chain omega-3 lipid emulsion (Omegaven 10%®, OGV) that contains fish oil (DHA 18 mg/ml; EPA 21 mg/ml) and α-tocopherol (0.2 mg/ml) in a transient middle cerebral artery occlusion (MCAO) model of ischemic stroke in mice. For this purpose, female CD-1 mice were anesthetized and subjected to 90 minutes of MCAO...
2016: PloS One
https://www.readbyqxmd.com/read/27614675/n-3-fatty-acid-based-parenteral-nutrition-improves-postoperative-recovery-for-cirrhotic-patients-with-liver-cancer-a-randomized-controlled-clinical-trial
#3
Binhao Zhang, Gang Wei, Rui Li, Yanjun Wang, Jie Yu, Rui Wang, Hua Xiao, Chao Wu, Chao Leng, Bixiang Zhang, Xiao-Ping Chen
BACKGROUND & AIMS: A new lipid emulsion enriched in n-3 fatty acid has been reported to prevent hepatic inflammation in patients following major surgery. However, the role of n-3 fatty acid-based parenteral nutrition for postoperative patients with cirrhosis-related liver cancer is unclear. We investigated the safety and efficacy of n-3 fatty acid-based parenteral nutrition for cirrhotic patients with liver cancer followed hepatectomy. METHODS: A prospective randomized controlled clinical trial (Registered under ClinicalTrials...
August 31, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27474222/multi-omic-profiles-of-hepatic-metabolism-in-tpn-fed-preterm-pigs-administered-new-generation-lipid-emulsions
#4
Gregory Guthrie, Madhulika Kulkarni, Hester Vlaardingerbroek, Barbara Stoll, Kenneth Ng, Camilia Martin, John Belmont, Darryl Hadsell, William Heird, Christopher B Newgard, Oluyinka Olutoye, Johannes van Goudoever, Charlotte Lauridsen, Xingxuan He, Edward H Schuchman, Douglas Burrin
We aimed to characterize the lipidomic, metabolomic, and transcriptomic profiles in preterm piglets administered enteral (ENT) formula or three parenteral lipid emulsions [parenteral nutrition (PN)], Intralipid (IL), Omegaven (OV), or SMOFlipid (SL), for 14 days. Piglets in all parenteral lipid groups showed differential organ growth versus ENT piglets; whole body growth rate was lowest in IL piglets, yet there were no differences in either energy expenditure or (13)C-palmitate oxidation. Plasma homeostatic model assessment of insulin resistance demonstrated insulin resistance in IL, but not OV or SL, compared with ENT...
September 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27342748/plasma-and-erythrocyte-uptake-of-omega-3-fatty-acids-from-an-intravenous-fish-oil-based-lipid-emulsion-in-patients-with-advanced-oesophagogastric-cancer
#5
A M Eltweri, A L Thomas, H L Fisk, A Arshad, P C Calder, A R Dennison, D J Bowrey
BACKGROUND: It has been demonstrated that short term intravenous (IV) administration of omega-3 polyunsaturated fatty acids (PUFAs) is more effective than oral supplementation at promoting incorporation of the bioactive omega-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into plasma, blood cells and tissues. The effect of repeated short term IV infusion of omega-3 PUFAs was investigated in patients with advanced oesophagogastric cancer during palliative chemotherapy...
June 7, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27322311/effectiveness-of-%C3%AF-3-polyunsaturated-fatty-acids-based-lipid-emulsions-for-treatment-of-patients-after-hepatectomy-a-prospective-clinical-trial
#6
Yuanfeng Gong, Zhaohui Liu, Yadi Liao, Cong Mai, Tiejun Chen, Hui Tang, Yunqiang Tang
OBJECTIVE: The present study aimed to investigate the effectiveness of parenteral nutritional support with ω-3 PUFAs-based lipid emulsions in patients after liver resection. METHODS: A total of 119 patients were randomly assigned to the immunonutrition (IM) group (n = 59) and control group (n = 60). The IM group was continuously given Omegaven(®) 10% 100 mL/day rather than regular nutrition for five days postoperatively. Venous blood samples were obtained from all subjects before surgery and D1, D3 and D7 after surgery...
2016: Nutrients
https://www.readbyqxmd.com/read/27143651/improvement-in-parenteral-nutrition-associated-cholestasis-with-the-use-of-omegaven-in-an-infant-with-short-bowel-syndrome
#7
Brian J Strang, Bruce A Reddix, Robert A Wolk
BACKGROUND: Parenteral nutrition-associated cholestasis (PNAC) and liver disease have been associated with soybean oil-based intravenous fat emulsions (IVFEs). The benefit of fish oil-based IVFEs in the reversal of parenteral nutrition (PN)-associated liver damage includes allowing for longer PN duration without immediate need for bowel or liver transplantation. METHODS: The present case involves an infant born with short bowel syndrome (SBS) requiring long-term PN with development of PNAC and subsequent administration of a fish oil-based IVFE...
October 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27072665/molecular-impact-of-omega-3-fatty-acids-on-lipopolysaccharide-mediated-liver-damage
#8
George Ventro, Min Chen, Yingkui Yang, Carroll M Harmon
BACKGROUND: Growing evidence suggests that omega 3 fatty acid containing lipid emulsions have a beneficial effect on parenteral nutrition associated liver disease (PNALD). However, the cellular and molecular mechanisms responsible for this effect are unclear. In this study, we investigated whether Omegaven™ fish oil emulsion could inhibit lipopolysaccharidase (LPS) mediated liver damage. METHODS: We examined the effects of Omegaven™ and LPS alone and synergistically on hepatic paraoxonase 1 (PON1), a potent antioxidant protein, ERK1/2 activity, and TLR4 regulation...
June 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26268565/-a-randomized-double-blind-study-of-the-effects-of-omega-3-fatty-acids-omegaven-on-outcome-after-major-liver-resection
#9
RANDOMIZED CONTROLLED TRIAL
Michael Linecker, Perparim Limani, Florin Botea, Irinel Popescu, Ruslan Alikhanov, Michail Efanov, Pavel Kim, Igor Khatkov, Dimitri Aristotele Raptis, Christoph Tschuor, Beatrice Beck-Schimmer, John Bonvini, Andrea Wirsching, Philipp Kron, Ksenija Slankamenac, Bostjan Humar, Rolf Graf, Henrik Petrowsky, Pierre-Alain Clavien
BACKGROUND: The body is dependent on the exogenous supply of omega-3 polyunsaturated fatty acids (n3-PUFA). These essential fatty acids are key players in regulating metabolic signaling but also exert anti-inflammatory and anti-carcinogenic properties. The liver is a major metabolic organ involved in fatty acid metabolism. Under experimental conditions, n3-PUFA exert beneficial effect on hepatic steatosis, regeneration and inflammatory insults such as ischemic injury after surgery. Some of these effects have also been observed in human subjects...
August 14, 2015: BMC Gastroenterology
https://www.readbyqxmd.com/read/26170701/cost-and-effectiveness-of-omega-3-fatty-acid-supplementation-in-chinese-icu-patients-receiving-parenteral-nutrition
#10
Guo Hao Wu, Jian Gao, Chun Yan Ji, Lorenzo Pradelli, Qiu Lei Xi, Qiu Lin Zhuang
BACKGROUND AND OBJECTIVES: Clinical evidence supports the use of omega-3 polyunsaturated fatty acid (PUFA)-enriched lipid emulsions in place of standard lipid emulsions in parenteral nutrition (PN) for intensive care unit (ICU) patients, but uptake may be limited by higher costs. We compared clinical and economic outcomes for these two types of lipid emulsion in the Chinese ICU setting. METHODS: We developed a pharmacoeconomic discrete event simulation model, based on efficacy data from an international meta-analysis and patient characteristics, resource consumption, and unit costs from a Chinese institutional setting...
2015: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/25954084/review-on-hepatic-explant-pathology-of-pediatric-intestinal-transplant-recipients-is-it-time-for-an-oil-change
#11
EDITORIAL
Essam Imseis, J Marc Rhoads
A recent study attempts to add to the body of evidence that is emerging regarding the fish oil parenteral lipid product Omegaven™. The authors have shown from explant livers of children on chronic parenteral nutrition with Omegaven™ that biochemical improvement in cholestasis does not always reflect improvement in liver histology. These findings support 2 small case series that were previously published. Despite improvement and resolution of hyperbilirubinemia in all six infants, five of six infants had persistent or progressive hepatic fibrosis, while only one infant had regression of fibrosis...
May 7, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25888960/modulation-of-endothelial-cell-integrity-and-inflammatory-activation-by-commercial-lipid-emulsions
#12
Kevin A Harvey, Zhidong Xu, Thomas M Pavlina, Gary P Zaloga, Rafat A Siddiqui
BACKGROUND: Thrombosis and immune dysfunction are two important complications that result from the administration of parenteral nutrition. Endothelial cells within the vasculature are crucial components necessary for maintenance of normal coagulation and immune function. METHODS: We compared the effects of three commercial lipid emulsions (LEs; Intralipid®, ClinOleic® [or Clinolipid®], and Omegaven®) differing in the levels of omega-6 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, omega-9 monounsaturated fatty acids, and saturated fatty acids upon endothelial cell fatty acid composition using Gas chromatography, endothelial cell integrity by assessing measurement of apoptosis and necrosis using flow cytometry, endothelial cell inflammatory activation by assessing the induction of ICAM-1 by lipopolysaccharide [LPS]), and transcription factor activation (phosphorylation of NF-κB) using western blot analysis...
2015: Lipids in Health and Disease
https://www.readbyqxmd.com/read/25685054/tocopherol-and-tocotrienol-homologs-in-parenteral-lipid-emulsions
#13
Zhidong Xu, Kevin A Harvey, Thomas M Pavlina, Gary P Zaloga, Rafat A Siddiqui
: Parenteral lipid emulsions, which are made of oils from plant and fish sources, contain different types of tocopherols and tocotrienols (vitamin E homologs). The amount and types of vitamin E homologs in various lipid emulsions vary considerably and are not completely known. The objective of this analysis was to develop a quantitative method to determine levels of all vitamin E homologs in various lipid emulsions. An HPLC system was used to measure vitamin E homologs using a Pinnacle DB Silica normal phase column and an isocratic, n-hexane:1,4 dioxane (98:2) mobile phase...
January 2015: European Journal of Lipid Science and Technology: EJLST
https://www.readbyqxmd.com/read/25596209/vitamin-e-in-new-generation-lipid-emulsions-protects-against-parenteral-nutrition-associated-liver-disease-in-parenteral-nutrition-fed-preterm-pigs
#14
Kenneth Ng, Barbara Stoll, Shaji Chacko, Miguel Saenz de Pipaon, Charlotte Lauridsen, Matthew Gray, E James Squires, Juan Marini, Irving J Zamora, Oluyinka O Olutoye, Douglas G Burrin
INTRODUCTION: Parenteral nutrition (PN) in preterm infants leads to PN-associated liver disease (PNALD). PNALD has been linked to serum accumulation of phytosterols that are abundant in plant oil but absent in fish oil emulsions. HYPOTHESIS: Whether modifying the phytosterol and vitamin E composition of soy and fish oil lipid emulsions affects development of PNALD in preterm pigs. METHODS: We measured markers of PNALD in preterm pigs that received 14 days of PN that included 1 of the following: (1) Intralipid (IL, 100% soybean oil), (2) Intralipid + vitamin E (ILE, d-α-tocopherol), (3) Omegaven (OV, 100% fish oil), or (4) Omegaven + phytosterols (PS, β-sitosterol, campesterol, and stigmasterol)...
July 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/25560679/reversal-of-intestinal-failure-associated-liver-disease-by-switching-from-a-combination-lipid-emulsion-containing-fish-oil-to-fish-oil-monotherapy
#15
Sanghoon Lee, Hyo Jung Park, Jihye Yoon, Seul Hee Hong, Chae-Youn Oh, Suk-Koo Lee, Jeong-Meen Seo
Intestinal failure-associated liver disease (IFALD) is a serious complication of parenteral nutrition (PN). Studies have shown that the amount and content of intravenous lipid emulsions (LEs) used is closely related to the development of IFALD. We report 2 cases of IFALD reversed by switching from a combination lipid emulsion containing fish oil to fish oil monotherapy (Omegaven; Fresenius Kabi Austria Gmbh, Graz, Austria). Patients initially received PN containing SMOFlipid 20% (SMOF; Fresenius Kabi Austria Gmbh, Graz, Austria), 2...
March 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/25502575/anti-inflammatory-and-anti-fibrotic-profile-of-fish-oil-emulsions-used-in-parenteral-nutrition-associated-liver-disease
#16
Alfonso Pastor-Clerigues, Ezequiel Marti-Bonmati, Javier Milara, Patricia Almudever, Julio Cortijo
Home parenteral nutrition (PN) is associated with many complications including severe hepatobiliary dysfunction. Commercial ω-6 fatty acid-soybean based-lipid emulsions in PN may mediate long term PN associate liver disease (PNALD) whereas ω-3-fish oil parenteral emulsions have shown to reverse PNALD in children. However, its clinical effectiveness in adults has been scarcely reported. In this work, we study the role of soybean and fish oil lipid commercial emulsions on inflammatory and profibrotic liver markers in adults with long term PNALD and in in vitro cellular models...
2014: PloS One
https://www.readbyqxmd.com/read/25326097/parenteral-soy-oil-and-fish-oil-emulsions-impact-of-dose-restriction-on-bile-flow-and-brain-size-of-parenteral-nutrition-fed-neonatal-piglets
#17
Jessica Josephson, Justine M Turner, Catherine J Field, Pamela R Wizzard, Patrick N Nation, Consolato Sergi, Ronald O Ball, Paul B Pencharz, Paul W Wales
BACKGROUND: Parenteral nutrition (PN)-associated liver disease (PNALD) remains a significant cause of morbidity and mortality for neonates dependent on PN. Total fat emulsion dose and composition, particularly the large amount of ω-6 long-chain polyunsaturated fatty acids in plant oils, have been proposed as risk factors for PNALD. We hypothesized restriction of the dose of emulsion would prevent PNALD, regardless of the composition, but growth could be compromised. METHODS: Using a neonatal piglet model, we compared conventional soy oil emulsion (Intralipid), dosed high (SO10, n = 8: 10 g/kg/d) and low (SO5, n = 6: 5 g/kg/d), with fish oil (Omegaven), dosed low (FO5, n = 8: 5 g/kg/d)...
August 2015: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/25173683/does-omegaven-have-beneficial-effects-on-a-rat-model-of-ovarian-ischemia-reperfusion
#18
Ayse N Cakir Gungor, Hakan Turkon, Aynur Albayrak, Mehmet Ovali, Mine Islimye, Meryem Gencer, Servet Hacivelioglu, Sibel Cevizci, Ismet Cesur, Emine Cosar
OBJECTIVE: The beneficial effects of omega-3 fatty acids on an intestinal ischemia/reperfusion (I/R) model was shown previously. Therefore, we aimed to examine the potential beneficial effects of parenteral omega-3 fatty acids, a safe and inexpensive product, on a rat model of ovarian I/R. STUDY DESIGN: A group of 39 rats was divided into six groups. Group 1 (Sham Group; n=6) underwent two laparotomies with a 3-h interval and their ovaries were removed 3h later...
October 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/24793206/hepatic-explant-pathology-of-pediatric-intestinal-transplant-recipients-previously-treated-with-omega-3-fatty-acid-lipid-emulsion
#19
Cal S Matsumoto, Stuart S Kaufman, Eddie R Island, Bhaskar Kallakury, Nada A Yazigi, Khalid M Khan, Thomas M Fishbein
OBJECTIVE: To evaluate and compare the biochemical and histologic effect of parenteral fish oil lipid emulsion that is rich in omega-3 polyunsaturated fatty acids (O3FAs), Omegaven (Fresenius Kabi AG, Bad Homburg, Germany) with standard omega-6 polyunsaturated fatty acid (O6FA) parenteral nutrition. STUDY DESIGN: Comparison of hepatic explant pathology and biochemical outcome on pediatric patients with intestinal failure treated with either parental O3FA or O6FA who had received a liver-inclusive intestine transplant...
July 2014: Journal of Pediatrics
https://www.readbyqxmd.com/read/24703629/parenteral-lipids-and-partial-enteral-nutrition-affect-hepatic-lipid-composition-but-have-limited-short-term-effects-on-formula-induced-necrotizing-enterocolitis-in-preterm-piglets
#20
Andreas Vegge, Thomas Thymann, Lotte Lauritzen, Stine B Bering, Bo Wiinberg, Per T Sangild
BACKGROUND & AIMS: Rapid transition from total parenteral nutrition (TPN) to enteral feeding is a risk factor for necrotizing enterocolitis (NEC) in preterm infants. We hypothesized that partial enteral nutrition with colostrum, increased proportion of n-3 polyunsaturated fatty acids (PUFA), or exclusion of lipid in TPN would affect short term NEC sensitivity and liver function. METHODS: Preterm piglets were fed for three days after birth: 1) TPN with a standard lipid emulsion (Nutriflex Lipid Plus, TPN control group, n = 19), 2) PN plus bovine colostrum as partial enteral nutrition (PN/COL, n = 18), 3) TPN with fish oil (FO) lipids (Omegaven, TPN/FO, n = 19), or 4) TPN with no lipid (TPN/NL, n = 22)...
April 2015: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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