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Endocytosis, signal transduction

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https://www.readbyqxmd.com/read/29877613/the-crossroads-of-receptor-mediated-signaling-and-endocytosis-in-plants
#1
Lucas Alves Neubus Claus, Daniel V Savatin, Eugenia Russinova
Plants deploy numerous plasma membrane receptors to sense and rapidly react to environmental changes. Correct localization and adequate protein levels of the cell-surface receptors are critical for signaling activation and modulation of plant development and defense against pathogens. After ligand binding, receptors are internalized for degradation and signaling attenuation. However, one emerging notion is that the ligand-induced endocytosis of receptor complexes is important for the signaling duration, amplitude, and specificity...
June 7, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29868263/sorting-nexin-1-is-a-candidate-tumor-suppressor-and-potential-prognostic-marker-in-gastric-cancer
#2
Xiao-Yong Zhan, Yaqiong Zhang, Ertao Zhai, Qing-Yi Zhu, Yulong He
Sorting nexin-1 (SNX1) is an important functional protein in cell endocytosis, efflux, protein sorting, cell signal transduction, etc; however, the expression, the role and clinical relevance of SNX1 have not been investigated in gastric cancer (GC). In this study, we first performed a bioinformatics investigation using the data obtained from The Cancer Genome Atlas (TCGA) database. The result showed that SNX1 mRNA levels were significantly lower in GC tissues than in paracancerous tissues. In a study of 150 cases of GC, including 60 cases with paired paracancerous and cancer tissues and 90 cases with detailed follow-up information, SNX1 expression was analyzed by immunohistochemistry...
2018: PeerJ
https://www.readbyqxmd.com/read/29789424/the-c-terminal-region-of-the-yeast-monocarboxylate-transporter-jen1-acts-as-a-glucose-signal-responding-degron-recognized-by-the-%C3%AE-arrestin-rod1
#3
Shoki Fujita, Daichi Sato, Hirokazu Kasai, Masataka Ohashi, Shintaro Tsukue, Yutaro Takekoshi, Katsuya Gomi, Takahiro Shintani
In response to changes in nutrient conditions, cells rearrange the composition of plasma membrane (PM) transporters to optimize their metabolic flux. Not only transcriptional gene regulation, but also inactivation of specific transporters is important for fast rearrangement of the PM. In eukaryotic cells, endocytosis plays a role in transporter inactivation, which is triggered by ubiquitination of these transporters. The Nedd4 family E3 ubiquitin ligase is responsible for ubiquitination of the PM transporters and requires that a series of α-arrestin proteins are targeted to these transporters...
May 22, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29777486/physiological-and-quantitative-proteomic-analyses-unraveling-potassium-deficiency-stress-response-in-alligator-weed-alternanthera-philoxeroides-l-root
#4
Li-Qin Li, Lun Liu, Wei Zhuo, Qian Chen, Sheng Hu, Shuang Peng, Xi-Yao Wang, Yi-Fei Lu, Li-Ming Lu
Physiological and iTRAQ based proteomic analysis provided new insights into potassium deficiency stress response in alligator weed root. Alligator weed (Alternanthera philoxeroides) has a strong ability to adapt to potassium deficiency (LK) stress. Proteomic changes in response to this stress are largely unknown in alligator weed. In this study, we investigated physiological and molecular mechanisms under LK using isobaric tags for relative and absolute quantitation to characterize proteome-level changes in this plant...
May 18, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29765007/from-intra-to-extracellular-vesicles-extracellular-vesicles-in-developmental-signalling
#5
REVIEW
Ana-Citlali Gradilla, Eléanor Simon, Gustavo Aguilar, Isabel Guerrero
Signalling from cell-to-cell is fundamental for determining differentiation and patterning. This communication can occur between adjacent and distant cells. Extracellular vesicles (EVs) are membrane-based structures thought to facilitate the long-distance movement of signalling molecules. EVs have recently been found to allow the transport of two major developmental signalling pathways: Hedgehog and Wnt. These signalling molecules undergo crucial post-translational lipid modifications, which anchor them to membranes and impede their free release into the extracellular space...
May 15, 2018: Essays in Biochemistry
https://www.readbyqxmd.com/read/29760588/in-vitro-gentamicin-exposure-alters-caveolae-protein-profile-in-cochlear-spiral-ligament-pericytes
#6
Elisa Ghelfi, Yohann Grondin, Emil J Millet, Adam Bartos, Magda Bortoni, Clara Oliveira Gomes Dos Santos, Humberto J Trevino-Villarreal, Rosalinda Sepulveda, Rick Rogers
Background: The aminoglycoside antibiotic gentamicin is an ototoxic drug and has been used experimentally to investigate cochlear damage induced by noise.We have investigated the changes in the protein profile associated with caveolae in gentamicin treated and untreated spiral ligament (SL) pericytes, specialized cells in the blood labyrinth barrier of the inner ear microvasculature. Pericytes from various microvascular beds express caveolae, protein and cholesterol rich microdomains, which can undergo endocytosis and transcytosis to transport small molecules in and out the cells...
2018: Proteome Science
https://www.readbyqxmd.com/read/29747819/protein-toxins-that-utilize-gangliosides-as-host-receptors
#7
Madison Zuverink, Joseph T Barbieri
Subsets of protein toxins utilize gangliosides as host receptors. Gangliosides are preferred receptors due to their extracellular localization on the eukaryotic cell and due to their essential nature in host physiology. Glycosphingolipids, including gangliosides, are mediators of signal transduction within and between eukaryotic cells. Protein toxins possess AB structure-function organization, where the A domain encodes a catalytic function for the posttranslational modification of a host macromolecule, including proteins and nucleic acids, and a B domain, which encodes host receptor recognition, including proteins and glycosphingolipids, alone or in combination...
2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29691252/high-usp6nl-levels-in-breast-cancer-sustain-chronic-akt-phosphorylation-and-glut1-stability-fueling-aerobic-glycolysis
#8
Daniele Avanzato, Emanuela Pupo, Nadia Ducano, Claudio Isella, Giovanni Bertalot, Chiara Luise, Salvatore Pece, Alejandra Bruna, Oscar M Rueda, Carlos Caldas, Pier Paolo Di Fiore, Anna Sapino, Letizia Lanzetti
USP6NL, also named RN-tre, is a GTPase activating protein (GAP) involved in control of endocytosis and signal transduction. Here we report that USP6NL is overexpressed in breast cancer (BC), mainly of the basal-like/integrative cluster 10 subtype. Increased USP6NL levels were accompanied by gene amplification and were associated with worse prognosis in the METABRIC dataset, retaining prognostic value in multivariable analysis. High levels of USP6NL in BC cells delayed endocytosis and degradation of the epidermal growth factor receptor (EGFR), causing chronic AKT activation...
April 24, 2018: Cancer Research
https://www.readbyqxmd.com/read/29615051/the-nuclear-transportation-routes-of-membrane-bound-transcription-factors
#9
REVIEW
Yang Liu, Peiyao Li, Li Fan, Minghua Wu
Membrane-bound transcription factors (MTFs) are transcription factors (TFs) that are anchored in membranes in a dormant state. Activated by external or internal stimuli, MTFs are released from parent membranes and are transported to the nucleus. Existing research indicates that some plasma membrane (PM)-bound proteins and some endoplasmic reticulum (ER) membrane-bound proteins have the ability to enter the nucleus. Upon specific signal recognition cues, some PM-bound TFs undergo proteolytic cleavage to liberate the intracellular fragments that enter the nucleus to control gene transcription...
April 3, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29562183/the-lis1-nde1-complex-is-essential-for-fgf-signaling-by-regulating-fgf-receptor-intracellular-trafficking
#10
Liansheng Liu, Jinqiu Lu, Xiaoling Li, Ailing Wu, Qingzhe Wu, Mujun Zhao, Nan Tang, Hai Song
Intracellular transport of membranous organelles and protein complexes to various destinations is fundamental to signaling transduction and cellular function. The cytoplasmic dynein motor and its regulatory proteins LIS1 and NDE1 are required for transporting a variety of cellular cargos along the microtubule network. In this study, we show that deletion of Lis1 in developing lung endoderm and limb mesenchymal cells causes agenesis of the lungs and limbs. In both mutants, there is increased cell death and decreased fibroblast growth factor (FGF) signaling activity...
March 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29543760/receptor-tyrosine-kinase-ubiquitination-and-de-ubiquitination-in-signal-transduction-and-receptor-trafficking
#11
REVIEW
William R Critchley, Caroline Pellet-Many, Benjamin Ringham-Terry, Michael A Harrison, Ian C Zachary, Sreenivasan Ponnambalam
Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid communication between cells and their environment. Evidence is now emerging that interdependent regulatory mechanisms, such as membrane trafficking, ubiquitination, proteolysis and gene expression, have substantial effects on RTK signal transduction and cellular responses. Different RTKs exhibit both basal and ligand-stimulated ubiquitination, linked to trafficking through different intracellular compartments including the secretory pathway, plasma membrane, endosomes and lysosomes...
March 15, 2018: Cells
https://www.readbyqxmd.com/read/29504311/roles-of-flotillins-in-tumors
#12
Xu-Xu Liu, Wei-Dong Liu, Lei Wang, Bin Zhu, Xiao Shi, Zi-Xuan Peng, He-Cheng Zhu, Xing-Dong Liu, Mei-Zuo Zhong, Dan Xie, Mu-Sheng Zeng, Cai-Ping Ren
The identification and use of molecular biomarkers have greatly improved the diagnosis and treatment of malignant tumors. However, a much deeper understanding of oncogenic proteins is needed for the benefit to cancer patients. The lipid raft marker proteins, flotillin-1 and flotillin-2, were first found in goldfish retinal ganglion cells during axon regeneration. They have since been found in a variety of cells, mainly on the inner surface of cell membranes, and not only act as a skeleton to provide a platform for protein-protein interactions, but also are involved in signal transduction, nerve regeneration, endocytosis, and lymphocyte activation...
2018: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29500444/metformin-induced-caveolin-1-expression-promotes-t-dm1-drug-efficacy-in-breast-cancer-cells
#13
Yuan-Chiang Chung, Ching-Ming Chang, Wan-Chen Wei, Ting-Wei Chang, King-Jen Chang, Wei-Ting Chao
Trastuzumab emtansine (T-DM1) is an antibody drug conjugate (ADC) that was recently approved for the treatment of HER-2-positive metastatic breast cancer. The drug sensitivity of ADCs depends mainly on the internalization efficiency of the drug. Caveolin-1 was shown to promote T-DM1 internalization and enhance drug sensitivity. Whether caveolin-1 can be overexpressed to improve T-DM1 efficacy is interesting and has the potential for clinical application. In this study, diabetes drug metformin was investigated in terms of induction of caveolin-1 expression for increased efficacy of subsequent T-DM1 application...
March 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29473018/a-global-analysis-of-kinase-function-in-candida-albicans-hyphal-morphogenesis-reveals-a-role-for-the-endocytosis-regulator-akl1
#14
Hagit Bar-Yosef, Tsvia Gildor, Bernardo Ramírez-Zavala, Christian Schmauch, Ziva Weissman, Mariel Pinsky, Rawi Naddaf, Joachim Morschhäuser, Robert A Arkowitz, Daniel Kornitzer
The human pathogenic fungus Candida albicans can switch between yeast and hyphal morphologies as a function of environmental conditions and cellular physiology. The yeast-to-hyphae morphogenetic switch is activated by well-established, kinase-based signal transduction pathways that are induced by extracellular stimuli. In order to identify possible inhibitory pathways of the yeast-to-hyphae transition, we interrogated a collection of C. albicans protein kinases and phosphatases ectopically expressed under the regulation of the TETon promoter...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29356040/basolateral-cd147-induces-hepatocyte-polarity-loss-by-e-cadherin-ubiquitination-and-degradation-in-hepatocellular-carcinoma-progress
#15
Meng Lu, Jiao Wu, Zhi-Wei Hao, Yu-Kui Shang, Jing Xu, Gang Nan, Xia Li, Zhi-Nan Chen, Huijie Bian
Hepatocytes are epithelial cells with highly specialized polarity. The disorder and loss of hepatocyte polarity leads to a weakness of cell adhesion and connection, the induction of epithelial-mesenchymal transition, and eventually the occurrence of hepatocellular carcinoma (HCC). Cluster of differentiation 147 (CD147), a tumor-related glycoprotein, promotes epithelial-mesenchymal transition and the invasion of HCC. However, the function of CD147 in hepatocyte depolarization is unknown. Here we identified that CD147 was basolaterally polarized in hepatocyte membrane of liver tissues and HepG2 cells...
January 21, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29305908/exostosin-like-2-regulates-fgf2-signaling-by-controlling-the-endocytosis-of-fgf2
#16
Satomi Nadanaka, Hiroshi Kitagawa
BACKGROUND: Heparan sulfate proteoglycans are ubiquitously expressed on cell surfaces and in extracellular matrices, and are engaged in heparin-binding growth factor-related signal transduction. Thus, changes in the amounts, structures, and chain lengths of heparan sulfate have profound effects on aspects of cell growth controlled by heparin-binding growth factors such as FGF2. Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate...
April 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29276316/a-new-electron-microscopic-method-to-observe-the-distribution-of-phosphatidylinositol-3-4-bisphosphate
#17
Sharmin Aktar, Sho Takatori, Takuma Tsuji, Minami Orii, Yuki Ohsaki, Jinglei Cheng, Toyoshi Fujimoto
Phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4)P2 ] is a phosphoinositide that plays important roles in signal transduction, endocytosis, and cell migration among others. The intracellular distribution of PtdIns(3,4)P2 has mainly been studied by observing the distribution of GFP-tagged PtdIns(3,4)P2 -binding protein domains in live cells and by labeling with anti-PtdIns(3,4)P2 antibody in fixed cell samples, but these methods only offer low spatial resolution results and may have pitfalls. In the present study, we developed an electron microscopic method to observe the PtdIns(3,4)P2 distribution using the SDS-treated freeze-fracture replica labeling method...
October 24, 2017: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/29200219/ordering-of-lipid-membranes-altered-by-boron-nitride-nanosheets
#18
Yonghui Zhang, Zhen Li, Chun Chan, Jiale Ma, Chunyi Zhi, Xiaolin Cheng, Jun Fan
Boron nitride nanosheets are novel promising nanomaterials with a lower cytotoxicity than graphene making them a better candidate for biomedical applications. However, there is no systematic study on how they interact with cell membranes. Here we employed large scale all-atom molecular dynamics simulations to provide molecular details of the structure and properties of membranes after the insertion of boron nitride nanosheets. Our results reveal that the boron nitride nanosheet can extract phospholipids from the lipid bilayers and is enveloped by the membrane...
February 7, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29161594/clathrin-assembly-defines-the-onset-and-geometry-of-cortical-patterning
#19
Yang Yang, Ding Xiong, Anne Pipathsouk, Orion D Weiner, Min Wu
Assembly of the endocytic machinery is a constitutively active process that is important for the organization of the plasma membrane, signal transduction, and membrane trafficking. Existing research has focused on the stochastic nature of endocytosis. Here, we report the emergence of the collective dynamics of endocytic proteins as periodic traveling waves on the cell surface. Coordinated clathrin assembly provides the earliest spatial cue for cortical waves and sets the direction of propagation. Surprisingly, the onset of clathrin waves, but not individual endocytic events, requires feedback from downstream factors, including FBP17, Cdc42, and N-WASP...
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29125865/membrane-order-in-the-plasma-membrane-and-endocytic-recycling-compartment
#20
David B Iaea, Frederick R Maxfield
The cholesterol content of membranes plays an important role in organizing membranes for signal transduction and protein trafficking as well as in modulating the biophysical properties of membranes. While the properties of model or isolated membranes have been extensively studied, there has been little evaluation of internal membranes in living cells. Here, we use a Nile Red based probe, NR12S, and ratiometric live cell imaging, to analyze the membrane order of the plasma membrane and endocytic recycling compartment...
2017: PloS One
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