Jeremy Anderson, Samira Imran, Yan Yung Ng, Tongtong Wang, Sarah Ashley, Cao Minh Thang, Le Quang Thanh, Vo Thi Trang Dai, Phan Van Thanh, Bui Thi Hong Nhu, Do Ngoc Xuan Trang, Phan Thi Phuong Trinh, Le Thanh Binh, Nguyen Thuong Vu, Nguyen Trong Toan, Boris Novakovic, Mimi L K Tang, Danielle Wurzel, Kim Mulholland, Daniel G Pellicci, Lien Anh Ha Do, Paul V Licciardi
BACKGROUND: Preterm infants are more likely to experience severe respiratory syncytial virus (RSV) disease compared to term infants. The reasons for this are multi-factorial, however their immature immune system is believed to be a major contributing factor. METHODS: We collected cord blood from 25 preterm (gestational age 30.4-34.1 weeks) and 25 term infants (gestation age 37-40 weeks) and compared the response of cord blood mononuclear cells (CBMCs) to RSVA and RSVB stimulation using neutralising assays, high-dimensional flow cytometry, multiplex cytokine assays and RNA-sequencing...
March 5, 2024: EBioMedicine