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https://www.readbyqxmd.com/read/27904030/formulation-optimization-and-in-vitro-characterization-of-orally-disintegrating-films-using-a-factorial-design-and-mathematical-modeling-for-drug-release
#1
Yeongbin Lee, Prakash Thapa, Seong Hoon Jeong, Mi Hee Woo, Du Hyung Choi
Even though experimental designs are becoming popular especially for conventional dosage forms, limited studies have been performed to optimize formulations of orally disintegrating films (ODFs). This study aimed to evaluate sildenafil citrate-loaded ODFs for a controlled release with hydroxypropyl methylcellulose as a film-forming polymer. A factorial design was utilized for optimization with three control factors: ethanol ratio, plasticizer ratio, and the type of plasticizer. Tensile strength, disintegration time, water contact angle, and thickness were chosen as responses...
November 30, 2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27900546/validation-of-the-chinese-version-of-functional-assessment-of-anorexia-cachexia-therapy-faact-scale-for-measuring-quality-of-life-in-cancer-patients-with-cachexia
#2
Ting Zhou, Kaixiang Yang, Sudip Thapa, Qiang Fu, Yongsheng Jiang, Shiying Yu
PURPOSE: The assessment of quality of life (QOL) is an important part of cachexia management for cancer patients. Functional assessment of anorexia-cachexia therapy (FAACT), a specific QOL instrument for cachexia patients, has not been validated in Chinese population. The aim of this study was to validate the FAACT scale in Chinese cancer patients for its future use. METHODS: Eligible cancer patients were included in our study. Patients' demographic and clinical characteristics were collected from the electronic medical records...
November 29, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27899093/microbiological-profile-of-corneal-ulcer-cases-diagnosed-in-a-tertiary-care-ophthalmological-institute-in-nepal
#3
Sharmila Suwal, Dinesh Bhandari, Pratigya Thapa, Mohan Krishna Shrestha, Jyoti Amatya
BACKGROUND: Corneal ulcer, a major cause of monocular blindness in developing countries has consistently been listed as the major cause of blindness and visual disability in many of the developing nations in Asia, Africa and the Middle East, ranking second only to cataract. This study was carried out to determine the microbiological profile of corneal ulcer cases diagnosed among patients visiting Tilganga Institute of Ophthalmology (TIO), Nepal. METHODS: A total of 101 corneal scrapping samples were tested for routine culture and antibiotic susceptibility at the pathology department of TIO Nepal from April to October 2014...
November 29, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27896312/the-memory-trace-supporting-lose-shift-responding-decays-rapidly-after-reward-omission-and-is-distinct-from-other-learning-mechanisms-in-rats
#4
Aaron J Gruber, Rajat Thapa
The propensity of animals to shift choices immediately after unexpectedly poor reinforcement outcomes is a pervasive strategy across species and tasks. We report here that the memory supporting such lose-shift responding in rats rapidly decays during the intertrial interval and persists throughout training and testing on a binary choice task, despite being a suboptimal strategy. Lose-shift responding is not positively correlated with the prevalence and temporal dependence of win-stay responding, and it is inconsistent with predictions of reinforcement learning on the task...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27892715/incorporation-of-chemotherapeutic-agent-and-photosensitizer-in-a-low-temperature-sensitive-liposome-for-effective-chemo-hyperthermic-anticancer-activity
#5
Hanh Thuy Nguyen, Tuan Hiep Tran, Raj Kumar Thapa, Tung Thanh Pham, Jee-Heon Jeong, Yu Seok Youn, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
OBJECTIVES: In this study, we combined chemo- and hyperthermia therapy in a low temperature-sensitive liposome (LTSL) for potential cancer treatment. METHODS: Docetaxel (DOC) and indocyanine green (ICG) as a therapeutic agent and photosensitizer, respectively, were incorporated in a low temperature-sensitive liposome (LTSL/DI). Nanoparticles were evaluated for the physicochemical characterizations, in vitro uptake and cytotoxicity, and furthermore in vivo anticancer activity...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892532/si-doped-t6-carbon-structure-as-an-anode-material-for-li-ion-batteries-an-ab-initio-study
#6
A Rajkamal, E Mathan Kumar, V Kathirvel, Noejung Park, Ranjit Thapa
First-principles calculations are performed to identify the pristine and Si doped 3D metallic T6 carbon structure (having both sp(2) and sp(3) type hybridization) as a new carbon based anode material. The π electron of C2 atoms (sp(2) bonded) forms an out of plane network that helps to capture the Li atom. The highest Li storage capacity of Si doped T6 structure with conformation Li1.7Si1C5 produces theoretical specific capacity of 632 mAh/g which substantially exceeding than graphite. Also, open-circuit voltage (OCV) with respect to Li metal shows large negative when compared to the pristine T6 structure...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27892443/medication-adherence-pattern-and-factors-affecting-adherence-in-helicobacter-pylori-eradication-therapy
#7
S Shakya Shrestha, M Bhandari, S R Thapa, R Shrestha, R Poudyal, B Purbey, R B Gurung
Background Helicobacter pylori (H. pylori) infection is the most common chronic bacterial infection worldwide affecting approximately half of the world's population. A number of screening tests as well as complex multi-drug therapies are available for the detection and treatment of H. pylori infection. However, the optimum eradication rates of H. pylori infection can only be achieved if adherence to drug therapy is higher. Therefore, it is of utmost importance to determine the factors leading to poor adherence to obtain successful treatment outcomes...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27892438/comparison-of-initial-response-of-nebulized-salbutamol-and-adrenaline-in-infants-and-young-children-admitted-with-acute-bronchiolitis
#8
S Adhikari, P Thapa, K S Rao, G Bk
Background Acute bronchiolitis is common cause of hospitalization in infants and young children. There are widespread variations in the diagnosis and management. Despite the use of bronchodilators for decades, there is lack of consensus for the benefit of one above another. Objective To compare initial response of nebulized adrenaline and salbutamol. Method Children aged two months to two years admitted with acute bronchiolitis in the department of Paediatrics of Manipal teaching hospital, Pokhara, Nepal, from 1st March 2014 to 28th February 2015 were enrolled...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27888587/tuberculosis-caused-by-mycobacterium-orygis-in-dairy-cattle-and-captured-monkeys-in-bangladesh-a-new-scenario-of-tuberculosis-in-south-asia
#9
Z Rahim, J Thapa, Y Fukushima, A G M van der Zanden, S V Gordon, Y Suzuki, C Nakajima
Mycobacterium orygis, commonly known as the oryx bacillus and a newly proposed Mycobacterium tuberculosis complex subspecies, was isolated from 18 cattle in a dairy farm and two captured rhesus monkeys in a zoo in Bangladesh. All the infected animals had tuberculosis lesions in their lungs, suggesting transmission and infection with M. orygis by an airborne route. The 20 isolates were analysed using a range of conventional and molecular typing methods, and RD-deletion typing and sequencing of selected genes confirmed the isolates as M...
November 25, 2016: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/27887586/hepatitis-e-virus-seroepidemiology-a-post-earthquake-study-among-blood-donors-in-nepal
#10
Ashish C Shrestha, Robert L P Flower, Clive R Seed, Manita Rajkarnikar, Shrawan K Shrestha, Uru Thapa, Veronica C Hoad, Helen M Faddy
BACKGROUND: As one of the causative agents of viral hepatitis, hepatitis E virus (HEV) has gained public health attention globally. HEV epidemics occur in developing countries, associated with faecal contamination of water and poor sanitation. In industrialised nations, HEV infections are associated with travel to countries endemic for HEV, however, autochthonous infections, mainly through zoonotic transmission, are increasingly being reported. HEV can also be transmitted by blood transfusion...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27885293/prevalence-of-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-isolated-from-urinary-tract-infected-patients
#11
P Chaudhary, D Bhandari, K Thapa, P Thapa, D Shrestha, H K Chaudhary, A Shrestha, H Parajuli, B P Gupta
BACKGROUND: Klebsiella pneumoniae, one of the bacterial agents associated with urinary tract infection has been often implicated as a major extended spectrum beta-lactamase (ESBL) producer in last few decades. This study was designed to assess the prevalence of ESBL producing Klebsiella pneumoniae in urinary isolates at a tertiary care hospital in Kathmandu, Nepal, from July to December 2014. METHODS: One thousand nine hundred eighty six mid-stream urine specimens were collected aseptically from the clinically suspected patients of urinary tract infections attending Capital Hospital and Research Center, Kathmandu...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27885288/correlation-between-clinical-features-and-magnetic-resonance-imaging-findings-in-lumbar-disc-prolapse
#12
S S Thapa, R B Lakhey, P Sharma, R K Pokhrel
BACKGROUND: Magnetic resonance imaging is routinely done for diagnosis of lumbar disc prolapse. Many abnormalities of disc are observed even in asymptomatic patient.This study was conducted tocorrelate these abnormalities observed on Magnetic resonance imaging and clinical features of lumbar disc prolapse. METHODS: A This prospective analytical study includes 57 cases of lumbar disc prolapse presenting to Department of Orthopedics, Tribhuvan University Teaching Hospital from March 2011 to August 2012...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27875827/disability-among-persons-aging-with-hiv-aids
#13
Suzanne G Leveille, Saurja Thapa
Persons surviving to older ages with HIV/AIDS often face an accelerated aging accompanied by increased comorbidity and decline in health and function. In this chapter, we review the process of disablement among persons aging with HIV/AIDS, from chronic conditions to impairments and functional limitations, leading to disability. Chronic immune activation related to chronic HIV infection may contribute to early development of chronic conditions that are common in older adults resulting in premature disablement...
2017: Interdisciplinary Topics in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27872776/cerebral-venous-sinus-thrombosis-during-everest-expedition-a-case-report-and-review-of-the-literature
#14
P Khanal, L Thapa, A M Shrestha, S Bhattarai, D Sapkota, N Sharma, U P Devkota
Cerebral venous sinus thrombosis (CVST) is a rare but serious disorder that is associated with a poor clinical outcome. We report a 35-year-old man who had a severe headache and diplopia while climbing Mount Everest. His MR venography showed right transverse and right sigmoid sinus thrombosis. He improved on anticoagulant and symptomatic measures. Cerebral venous sinus thrombosis at high altitude is discussed.
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27870828/agonist-stimulated-phosphatidylinositol-3-4-5-trisphosphate-generation-by-scaffolded-phosphoinositide-kinases
#15
Suyong Choi, Andrew C Hedman, Samar Sayedyahossein, Narendra Thapa, David B Sacks, Richard A Anderson
Generation of the lipid messenger phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) is crucial for development, cell growth and survival, and motility, and it becomes dysfunctional in many diseases including cancers. Here we reveal a mechanism for PtdIns(3,4,5)P3 generation by scaffolded phosphoinositide kinases. In this pathway, class I phosphatidylinositol-3-OH kinase (PI(3)K) is assembled by IQGAP1 with PI(4)KIIIα and PIPKIα, which sequentially generate PtdIns(3,4,5)P3 from phosphatidylinositol...
November 21, 2016: Nature Cell Biology
https://www.readbyqxmd.com/read/27865750/outcomes-following-radical-cystectomy-for-plasmacytoid-urothelial-carcinoma-defining-the-need-for-improved-local-cancer-control
#16
Patrick A Cockerill, John C Cheville, Stephen A Boorjian, Andrew Blackburne, Prabin Thapa, Robert F Tarrell, Igor Frank
OBJECTIVE: To evaluate oncologic outcomes after radical cystectomy (RC) in patients with plasmacytoid urothelial carcinoma (UC), and compared survival to that in patients with pure UC of the bladder. METHODS: We identified 46 patients with plasmacytoid UC and 972 with pure UC who were treated with RC between 1980 and 2009. All pathologic specimens were re-reviewed by a single GU pathologist. Patients were matched 1:2 by age, gender, ECOG performance status, pathological tumor stage and nodal status to patients with pure UC...
November 16, 2016: Urology
https://www.readbyqxmd.com/read/27835999/serial-survey-shows-community-intervention-may-contribute-to-increase-in-knowledge-of-tuberculosis-in-30-districts-of-india
#17
Badri Thapa, Banuru Muralidhara Prasad, Sarabjit S Chadha, Jamie Tonsing
BACKGROUND: Correct knowledge about Tuberculosis (TB) is essential for appropriate healthcare seeking behaviour and to accessing diagnosis and treatment services timely. There are several factors influencing knowledge about TB. The present study was conducted to assess the change in community knowledge of Tuberculosis (TB) and its association with respondent's socio-demographic characteristics in two serial knowledge-attitude-practice surveys. METHODS: Community level interventions including community meetings with youth groups, village health committees and self-help groups and through mass media activities were undertaken to create awareness and knowledge about TB and service availability...
November 11, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27832584/getting-a-grip-on-flu-by-casting-the-dai
#18
Danielle M Clancy, Seamus J Martin
Influenza A initiates host cell death through unknown mechanisms. Thapa et al. (2016) in this issue of Cell Host & Microbe, along with recent work by Kuriakose et al. (2016), indicate that this virus provokes divergent modes of cell death, including apoptosis and necroptosis, via the nucleic acid sensor, DAI.
November 9, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27831933/aerodynamic-parameters-from-distributed-heterogeneous-cnt-hair-sensors-with-a-feedforward-neural-network
#19
Kaman Thapa Magar, Gregory W Reich, Corey Kondash, Keith Slinker, Alexander M Pankonien, Jeffery W Baur, Brian Smyers
Distributed arrays of artificial hair sensors have bio-like sensing capabilities to obtain spatial and temporal surface flow information which is an important aspect of an effective fly-by-feel system. The spatiotemporal surface flow measurement enables further exploration of additional flow features such as flow stagnation, separation, and reattachment points. Due to their inherent robustness and fault tolerant capability, distributed arrays of hair sensors are well equipped to assess the aerodynamic and flow states in adverse conditions...
November 10, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27828505/infrared-glass-based-negative-curvature-anti-resonant-fibers-fabricated-through-extrusion
#20
Rafael R Gattass, Daniel Rhonehouse, Daniel Gibson, Collin C McClain, Rajesh Thapa, Vinh Q Nguyen, Shyam S Bayya, R Joseph Weiblen, Curtis R Menyuk, L Brandon Shaw, Jasbinder S Sanghera
Negative curvature fibers have been gaining attention as fibers for high power infrared light. Currently, these fibers have been made of silica glass and infrared glasses solely through stack and draw. Infrared glasses' lower softening point presents the opportunity to perform low-temperature processing methods such as direct extrusion of pre-forms. We demonstrate an infrared-glass based negative curvature fiber fabricated through extrusion. The fiber shows record low losses in 9.75 - 10.5 µm range (which overlaps with the CO<sub>2</sub> emission bands)...
October 31, 2016: Optics Express
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