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https://www.readbyqxmd.com/read/28917152/pegylated-thermosensitive-lipid-coated-hollow-gold-nanoshells-for-effective-combinational-chemo-photothermal-therapy-of-pancreatic-cancer
#1
Bijay Kumar Poudel, Biki Gupta, Thiruganesh Ramasamy, Raj Kumar Thapa, Shiva Pathak, Kyung Taek Oh, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Pancreatic cancer has extremely poor prognosis with an 85% mortality rate that results from aggressive and asymptomatic growth, high metastatic potential, and rapid development of resistance to already ineffective chemotherapy. In this study, plasmonic hollow gold nanoshells (GNS) coated with PEGylated thermosensitive lipids were prepared as an efficient platform to ratiometrically co-deliver two drugs, bortezomib and gemcitabine (GNS-L/GB), for combinational chemotherapy and photothermal therapy of pancreatic cancer...
September 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28914185/power-potential-and-pitfalls-in-global-health-academic-partnerships-review-and-reflections-on-an-approach-in-nepal
#2
David Citrin, Stephen Mehanni, Bibhav Acharya, Lena Wong, Isha Nirola, Rekha Sherchan, Bikash Gauchan, Khem Bahadur Karki, Dipendra Raman Singh, Sriram Shamasunder, Phuoc Le, Dan Schwarz, Ryan Schwarz, Binod Dangal, Santosh Kumar Dhungana, Sheela Maru, Ramesh Mahar, Poshan Thapa, Anant Raut, Mukesh Adhikari, Indira Basnett, Shankar Prasad Kaluanee, Grace Deukmedjian, Scott Halliday, Duncan Maru
BACKGROUND: Global health academic partnerships are centered around a core tension: they often mirror or reproduce the very cross-national inequities they seek to alleviate. On the one hand, they risk worsening power dynamics that perpetuate health disparities; on the other, they form an essential response to the need for healthcare resources to reach marginalized populations across the globe. OBJECTIVES: This study characterizes the broader landscape of global health academic partnerships, including challenges to developing ethical, equitable, and sustainable models...
2017: Global Health Action
https://www.readbyqxmd.com/read/28913666/quantitative-modeling-of-the-dynamics-and-intracellular-trafficking-of-far-red-light-activatable-prodrugs-implications-in-stimuli-responsive-drug-delivery-system
#3
Mengjie Li, Pritam Thapa, Pallavi Rajaputra, Moses Bio, Cody J Peer, William D Figg, Youngjae You, Sukyung Woo
The combination of photodynamic therapy (PDT) with anti-tumor agents is a complimentary strategy to treat local cancers. We developed a unique photosensitizer (PS)-conjugated paclitaxel (PTX) prodrug in which a PS is excited by near-infrared wavelength light to site-specifically release PTX while generating singlet oxygen (SO) to effectively kill cancer cells with both PTX and SO. The aim of the present study was to identify the determinants influencing the combined efficacy of this light-activatable prodrug, especially the bystander killing effects from released PTX...
September 14, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28913657/radical-cystectomy-for-recurrent-urothelial-carcinoma-after-prior-partial-cystectomy-perioperative-and-oncologic-outcomes
#4
Ross J Mason, Igor Frank, Bimal Bhindi, Matthew K Tollefson, R Houston Thompson, R Jeffrey Karnes, Robert Tarrell, Prabin Thapa, Stephen A Boorjian
PURPOSE: To evaluate perioperative and oncologic outcomes of patients undergoing radical cystectomy (RC) for recurrence of urothelial carcinoma (UC) after prior partial cystectomy (PC), and to compare these outcomes to patients undergoing primary RC. METHODS: Patients who underwent RC for recurrence of UC after prior PC were matched 1:3 to patients undergoing primary RC based on age, pathologic stage, and decade of surgery. Perioperative and oncologic outcomes were compared using Wilcoxon sign-rank test, McNemars test, the Kaplan-Meier method, and Cox proportional hazards regression analyses...
September 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28905468/preventive-dental-checkups-and-their-association-with-access-to-usual-source-of-care-among-rural-and-urban-adult-residents
#5
Aishah Khan, Janani R Thapa, Donglan Zhang
PURPOSE: This study aimed to assess the relationship between rural or urban residence and having a usual source of care (USC), and the utilization of preventive dental checkups among adults. METHODS: Cross-sectional analysis was conducted using data from the Medical Expenditure Panel Survey 2012. We performed a logit regression on the relationship between rural and urban residence, having a USC, and having at least 1 dental checkup in the past year, adjusting for sociodemographic characteristics and health status...
September 14, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28882756/opening-a-can-of-worms-leprosy-reactions-and-complicit-soil-transmitted-helminths
#6
Deanna A Hagge, Pawan Parajuli, Chhatra B Kunwar, Divya R S J B Rana, Ruby Thapa, Kapil D Neupane, Peter Nicholls, Linda B Adams, Annemieke Geluk, Mahesh Shah, Indra B Napit
BACKGROUND: >94% of new annual leprosy cases are diagnosed in populations co-endemic for soil-transmitted helminths (STH). STH can profoundly dysregulate host immune responses towards Th2 bias, which can be restored over time after deworming. We hypothesize that STH co-infection is associated with leprosy reaction (denoted as simply "reaction" herein) occurrence within a co-endemic population. METHODS: A cohort study was performed on a cohort of Nepalese leprosy patients across treatment and diagnostic classifications who were screened by routine fecal smear microscopy and multiplex quantitative PCR (qPCR) for Ascaris lumbricoides (Al), Strongyloides stercoralis (Ss), Ancyclostoma duodenale (Ad) and Necator americanus (Na)...
September 1, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28874781/immunization-of-cervidized-transgenic-mice-with-multimeric-deer-prion-protein-induces-self-antibodies-that-antagonize-chronic-wasting-disease-infectivity-in-vitro
#7
Dalia H Abdelaziz, Simrika Thapa, Basant Abdulrahman, Li Lu, Shikha Jain, Hermann M Schatzl
Chronic wasting disease (CWD) is the most contagious prion disease. It is expanding rapidly in North America, was found recently in Europe, and the potential for transmission to humans cannot be excluded yet. We hypothesized that it is possible to prevent peripheral CWD infection and CWD prion shedding by inducing auto-antibodies against the cellular prion protein (PrP(C)) by active vaccination. Our objective is to overcome self-tolerance against PrP by using a multimeric recombinant PrP (recPrP) as an immunogen...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874362/drug-resistance-in-malaria-tuberculosis-and-hiv-in-south-east-asia-biology-programme-and-policy-considerations
#8
Samiran Panda, Soumya Swaminathan, Khurshid A Hyder, Eva-Maria Christophel, Razia N Pendse, Achuthan N Sreenivas, Setiwan J Laksono, Rahul Srivastava, Gopinath B Nair, Tjandra Y Aditama, Pratap Singhasivanon, Arun B Thapa, Swarup K Sarkar
No abstract text is available yet for this article.
September 5, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28870292/nutrients-and-host-attributes-modulate-the-abundance-and-functional-traits-of-phyllosphere-microbiome-in-rice
#9
Shobit Thapa, Radha Prasanna, Kunal Ranjan, Kulandaivelu Velmourougane, Balasubramanian Ramakrishnan
The abundance of phyllosphere bacterial communities of seven genotypes of rice ADT- 38, ADT-43, CR-1009, PB-1, PS-5, P-44, and PB-1509 was investigated, in relation to nutrient dynamics of rhizosphere and leaves. P-44 genotype recorded highest pigment accumulation, while genotypes CR-1009 and P-44 exhibited most number of different bacterial morphotypes, Colony forming units in two media (Nutrient agar and R2A) varied significantly and ranged from 10(6)-10(7) per g plant tissues. Among the selected 60 distinct morphotypes, IAA and siderophore producers were the dominant functional types...
November 2017: Microbiological Research
https://www.readbyqxmd.com/read/28865424/prevalence-pattern-and-risk-factors-of-retinal-vein-occlusion-in-an-elderly-population-in-nepal-the-bhaktapur-retina-study
#10
Raba Thapa, Sanyam Bajimaya, Govinda Paudyal, Shankar Khanal, Stevie Tan, Suman S Thapa, Ger van Rens
BACKGROUND: This study aims to explore the prevalence, pattern and risk factors of retinal vein occlusion (RVO) in an elderly population of Nepal. METHOD: One thousand eight hundred sixty subjects of age 60 years and above were enrolled in a population-based, cross-sectional study. Detailed history, visual acuity, anterior segment and posterior segment examinations were done. Blood pressure, non-fasting blood sugar, body mass index and abdominal girth were measured...
September 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28863385/tumour-radiosensitivity-is-associated-with-immune-activation-in-solid-tumours
#11
Tobin Strom, Louis B Harrison, Anna R Giuliano, Michael J Schell, Steven A Eschrich, Anders Berglund, William Fulp, Ram Thapa, Domenico Coppola, Sungjune Kim, Jessica Frakes, John Foekens, James J Mulé, Javier F Torres-Roca
PURPOSE: Our goal was to determine whether tumour radiosensitivity is associated with activation of the immune system across all tumour types as measured by two gene expression signatures (GESs). METHODS: We identified 10,240 genomically profiled distinct solid primary tumours with gene expression analysis available from an institutional de-identified database. Two separate GESs were included in the analysis, the radiosensitivity index (RSI) GES (a 10-gene GES as a measure of radiosensitivity) and the 12-chemokine (12-CK) signature (a 12-gene GES as a measure of immune activation)...
August 29, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28851796/determinants-of-severe-acute-malnutrition-among-children-under-5-years-of-age-in-nepal-a-community-based-case-control-study
#12
Nilesh Kumar Pravana, Suneel Piryani, Surendra Prasad Chaurasiya, Rasmila Kawan, Ram Krishna Thapa, Sumina Shrestha
BACKGROUND: Malnutrition is one of the leading causes of morbidity and mortality among children under the age of 5 years in low and middle income countries like Nepal. Children with severe acute malnutrition (SAM) are nine times more likely to die than children without malnutrition. The prevalence of SAM has increased in Nepal over the past 15 years; however, the determinants of SAM have not been clearly assessed in the country. OBJECTIVE: To assess the determinants of SAM among children aged 6-59 months in the Bara district of Nepal...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28844793/utilization-and-outcomes-of-radical-cystectomy-for-high-grade-non-muscle-invasive-bladder-cancer-in-elderly-patients
#13
William P Parker, Woodson Smelser, Eugene K Lee, Elizabeth B Habermann, Prabin Thapa, Harras B Zaid, Igor Frank, Tomas L Griebling, Matthew K Tollefson, R Houston Thompson, Jeffrey M Holzbeierlein, R Jeffrey Karnes, Stephen A Boorjian
BACKGROUND: Radical cystectomy (RC) represents a treatment option for patients with high-grade non-muscle-invasive bladder cancer (HG-NMIBC); however, perioperative morbidity is not insignificant, particularly in elderly patients. We sought to evaluate the associations of age with utilization and outcomes of RC for HG-NMIBC. PATIENTS AND METHODS: Patients with HG-NMIBC diagnosed between 2004 and 2013 were identified in the National Cancer Database and stratified by age: ≤ 60, 61-70, 71-80, and > 80 years...
August 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28844641/performance-of-an-ipad-application-to-detect-moderate-and-advanced-visual-field-loss-in-nepal
#14
Chris A Johnson, Suman Thapa, Yu Xiang George Kong, Alan L Robin
PURPOSE: To evaluate the accuracy and efficiency of Visual Fields Easy (VFE), a free iPad app, for performing suprathreshold perimetric screening. METHODS: We performed screening visual fields using a calibrated iPad 2 with the VFE application on 206 subjects (411 eyes): 210 normal (NL), 183 glaucoma (GL) and 18 diabetic retinopathy (DR) at Tilganga Institute of Ophthalmology, Kathmandu, Nepal. We correlated the results with a Humphrey Field Analyzer using 24-2 SITA Standard tests on 273 of these eyes (198 NL, 160 GL, 15 DR) RESULTS: The number of missed locations on the VFE correlated with Mean Deviation (MD, r=0...
August 24, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28839478/epidemiology-of-surgically-managed-mandibular-condylar-fractures-at-a-tertiary-referral-hospital-in-urban-southwest-china
#15
Swosti Thapa, Jun Wang, Hong-Tao Hu, Fu-Gui Zhang, Ping Ji
BACKGROUND: Mandibular condylar fracture is one of the commonest maxillofacial fractures treated by maxillofacial surgeons. Demography of the patients, causation, and characteristics of the fracture depends on various socio-economic factors. Hence, maxillofacial surgeons should be familiar with epidemiology of mandibular condylar fracture. OBJECTIVE: This study retrospectively describes the demography, etiology, fracture characteristics, and hospital utilization of surgically treated mandibular condylar fractures in a tertiary referral hospital in urban China in past five years...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28838177/the-switch-from-trivalent-to-bivalent-oral-poliovirus-vaccine-in-the-south-east-asia-region
#16
Sunil Bahl, Andreas Hasman, Abu Obeida Eltayeb, Douglas James Noble, Arun Thapa
This analysis describes an innovative and successful approach to risk identification and mitigation in relation to the switch from trivalent to bivalent oral polio vaccine (OPV) in the 11 countries of the World Health Organization's (WHO's) South-East Asia Region (SEAR) in April 2016.The strong commitment of governments and immunization professionals to polio eradication and an exemplary partnership between the WHO, United Nations Children's Fund (UNICEF), and other partners and stakeholders in the region and globally were significant contributors to the success of the OPV switch in the SEAR...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28826737/thiol-dioxygenase-turnover-yields-benzothiazole-products-from-2-mercaptoaniline-and-o2-dependent-oxidation-of-primary-alcohols
#17
William P Morrow, Sinjinee Sardar, Pawan Thapa, Mohammad S Hossain, Frank W Foss, Brad S Pierce
Thiol dioxygenases are non-heme mononuclear iron enzymes that catalyze the O2-dependent oxidation of free thiols (-SH) to produce the corresponding sulfinic acid (-SO2(-)). Previous chemical rescue studies identified a putative Fe(III)-O2(-) intermediate that precedes substrate oxidation in Mus musculus cysteine dioxygenase (Mm CDO). Given that a similar reactive intermediate has been identified in the extradiol dioxygenase 2, 3-HCPD, it is conceivable that these enzymes share other mechanistic features with regard to substrate oxidation...
October 1, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28822512/implications-of-the-2013-acc-aha-cholesterol-guidelines-on-contemporary-clinical-practice-for-patients-with-atherosclerotic-coronary-and-peripheral-arterial-disease
#18
Prasad Gunasekaran, Vinodh Jeevanantham, Suresh Sharma, Rashmi Thapa, Kamal Gupta
BACKGROUND: Cholesterol management guidelines from the American College of Cardiology/American Heart Association (ACC/AHA-2013) recommend fixed statin dosing (dose depends on age ≤ or >75years) compared to the earlier adult treatment panel III (ATPIII) guidelines which recommended specific low-density lipoprotein-cholesterol (LDL-C) targets. Clinical implications of this recommendation are not known. METHODS: We retrospectively compared cholesterol levels and statin utilization across cohorts with coronary artery disease (CAD) (n=9563), peripheral arterial disease (PAD) (n=596) and CAD+PAD (n=975) by applying both guidelines...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28813599/tetraterpene-synthase-substrate-and-product-specificity-in-the-green-microalga-botryococcus-braunii-race-l
#19
Hem R Thapa, Su Tang, James C Sacchettini, Timothy P Devarenne
Recently, the biosynthetic pathway for lycopadiene, a C40 tetraterpenoid hydrocarbon, was deciphered from the L race of Botryococcus braunii, an alga that produces hydrocarbon oils capable of being converted into combustible fuels. The lycopadiene pathway is initiated by the squalene synthase (SS)-like enzyme lycopaoctaene synthase (LOS), which catalyzes the head-to-head condensation of two C20 geranylgeranyl diphosphate (GGPP) molecules to produce C40 lycopaoctaene. LOS shows unusual substrate promiscuity for SS or SS-like enzymes by utilizing C15 farnesyl diphosphate (FPP) and C20 phytyl diphosphate in addition to GGPP as substrates...
August 25, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28811950/autoscopic-hallucination-in-alcohol-dependence-syndrome-a-rare-or-missed-phenomenon
#20
Sulochana Joshi, Binita Thapa, Rabi Shakya
Autoscopic phenomenon, a psychic illusionary duplication of one's own self, has been the subject of interest in the literature and science for years. It has been reported in various diseases of the central nervous system but with an unknown mechanism. Hallucinations are a common presentation in alcohol dependence syndrome during delirium tremens and as induced disorder. However, autoscopic hallucination has been rarely reported in the cases of alcohol dependence. We present a case of a 40-year-old man who experienced autoscopic hallucination during the withdrawal state of alcohol...
2017: Case Reports in Psychiatry
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