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https://www.readbyqxmd.com/read/28086925/partnerships-in-mental-healthcare-service-delivery-in-low-resource-settings-developing-an-innovative-network-in-rural-nepal
#1
Bibhav Acharya, Duncan Maru, Ryan Schwarz, David Citrin, Jasmine Tenpa, Soniya Hirachan, Madhur Basnet, Poshan Thapa, Sikhar Swar, Scott Halliday, Brandon Kohrt, Nagendra P Luitel, Erick Hung, Bikash Gauchan, Rajeev Pokharel, Maria Ekstrand
BACKGROUND: Mental illnesses are the largest contributors to the global burden of non-communicable diseases. However, there is extremely limited access to high quality, culturally-sensitive, and contextually-appropriate mental healthcare services. This situation persists despite the availability of interventions with proven efficacy to improve patient outcomes. A partnerships network is necessary for successful program adaptation and implementation. PARTNERSHIPS NETWORK: We describe our partnerships network as a case example that addresses challenges in delivering mental healthcare and which can serve as a model for similar settings...
January 13, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28077087/embryogenesis-in-the-parasitic-nematode-heterodera-glycines-is-independent-of-host-derived-hatching-stimulation
#2
Sita Thapa, Jayna A Patel, Ursula Reuter-Carlson, Nathan E Schroeder
BACKGROUND: Many parasites regulate their development to synchronize their life cycle with a compatible host. The parasitic nematode Heterodera glycines displays incomplete host-mediated hatching behavior wherein some H. glycines individuals hatch only in the presence of a host-derived cue while others hatch in water alone. Furthermore, H. glycines shows variable hatching behavior based on oviposition location. The mechanisms regulating this hatching variability are unknown. In this study, we established a detailed timeline of the H...
January 11, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28068603/rational-design-synthesis-and-evaluation-of-novel-2-4-chloro-and-hydroxy-substituted-diphenyl-benzofuro-3-2-b-pyridines-non-intercalative-catalytic-topoisomerase-i-and-ii-dual-inhibitor
#3
Seojeong Park, Til Bahadur Thapa Magar, Tara Man Kadayat, Hwa Jong Lee, Ganesh Bist, Aarajana Shrestha, Eung-Seok Lee, Youngjoo Kwon
Novel series of conformationally constrained 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2-b]pyridines were rationally designed and synthesized. Their biological activities were evaluated for topoisomerase I and II inhibitory activity, and antiproliferative activity against several human cancer cell lines for the development of novel anticancer agents. Most of the compounds with phenol moiety at 4-position of central pyridine exhibited significant dual topoisomerase I and II inhibitory activities, and strong antiproliferative activity in low micromolar range...
January 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28067204/cd9-monoclonal-antibody-conjugated-pegylated-liposomes-for-targeted-delivery-of-rapamycin-in-the-treatment-of-cellular-senescence
#4
Hanh Thuy Nguyen, Raj Kumar Thapa, Beom Soo Shin, Jee-Heon Jeong, Jae-Ryong Kim, Chul Soon Yong, Jong Oh Kim
Premature cellular senescence refers to the state of irreversible cell cycle arrest due to DNA damage or other stresses. In this study, CD9 monoclonal antibody (CD9mAb) was successfully conjugated to the surface of PEGylated liposomes for targeted delivery of rapamycin (LR-CD9mAb) to overcome senescence of CD9 receptor-overexpressing cells. LR-CD9mAb has a small particle size (143.3 �� 2.4 nm), narrow size distribution (polydispersity index: 0.220 �� 0.036), and negative zeta potential (���14...
January 9, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28062340/differences-in-symptom-burden-among-cancer-patients-with-different-stages-of-cachexia
#5
Ting Zhou, Kaixiang Yang, Sudip Thapa, Huiquan Liu, Bangyan Wang, Shiying Yu
CONTEXT: Cancer patients with cachexia may suffer from significant burden of symptoms and it can severely impair patients' quality of life. However, only few studies have targeted the symptom burden in cancer cachexia patients, and whether the symptom burden differed in different cachexia stages is still unclear. OBJECTIVES: The aims of this study were to evaluate the symptom burden in cancer cachexia patients, and to compare the severity and occurrence rates of symptoms among cancer patients with non-cachexia, pre-cachexia, cachexia and refractory cachexia...
January 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28059110/incommensurate-graphene-foam-as-a-high-capacity-lithium-intercalation-anode
#6
Tereza M Paronyan, Arjun Kumar Thapa, Andriy Sherehiy, Jacek B Jasinski, John Samuel Dilip Jangam
Graphite's capacity of intercalating lithium in rechargeable batteries is limited (theoretically, 372 mAh g(-1)) due to low diffusion within commensurately-stacked graphene layers. Graphene foam with highly enriched incommensurately-stacked layers was grown and applied as an active electrode in rechargeable batteries. A 93% incommensurate graphene foam demonstrated a reversible specific capacity of 1,540 mAh g(-1) with a 75% coulombic efficiency, and an 86% incommensurate sample achieves above 99% coulombic efficiency exhibiting 930 mAh g(-1) specific capacity...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28049375/comparative-effectiveness-of-treatment-choices-for-graves-hyperthyroidism-a-historical-cohort-study
#7
Vishnu Sundaresh, Juan P Brito, Prabin Thapa, Rebecca S Bahn, Marius N Stan
Introduction The optimum therapy for Graves' Disease (GD) is chosen following discussion between physician and patient regarding benefits, drawbacks, potential side effects, and logistics of the various treatment options and takes into account patient values and preferences. This cohort study aimed to provide useful information for this discussion regarding the usage, efficacy and adverse effect profile of radioactive iodine (RAI), antithyroid drugs (ATDs), and thyroidectomy in a tertiary healthcare facility...
January 3, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28045732/hepatobiliary-scintigraphy-findings-lead-to-the-diagnosis-of-spontaneous-common-bile-duct-rupture-in-an-infant
#8
Ashwani Sood, Ashwin Singh Parihar, Babu Ram Thapa, Ravi Prakash Kanojia, Bhagwant Rai Mittal, Anish Bhattacharya
Hepatobiliary scintigraphy is a widely used functional imaging modality for diagnosis of a variety of liver diseases, as well as for detecting biliary tract abnormalities. Neonates or infants with persistent jaundice beyond the physiological period are usually evaluated with hepatobiliary scintigraphy. The authors present a 5-month-old girl with neonatal jaundice, ascites, and umbilical and bilateral inguinal hernias in whom spontaneous rupture of the biliary duct resulted in intraperitoneal bile leak with passage of tracer into bilateral inguinal hernial sacs...
December 30, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28029669/safety-and-efficacy-of-spinal-anaesthesia-in-percutaneous-nephrolithotomy
#9
R Shah, A S Thapa, N Lamichhane, S R Kc
INTRODUCTION: Renal stone is one of the common entities occurring in our population. There are different treatment modalities of stones; out of those percutaneous nephrolithotomy is one of the most popular and effective for the renal and upper tract stones. This study is based to compare the safety and efficacy of spinal anaesthesia and general anaesthesia in PCNL. METHODS: In a randomized prospective study 60 patients were divided in two groups; group 1 (n=30) underwent PCNL in general anaesthesia and group 2 (n=30) underwent PCNL in spinal anaesthesia in prone position with the conventional technique...
October 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28028304/zollinger-ellison-syndrome-an-unusual-case-of-chronic-diarrhoea-in-a-child
#10
R Goyal, U Debi, P Dey, K K Prasad, B R Thapa
Most cases of Zollinger-Ellison syndrome (ZES) are described in adults. It is a rare disorder in childhood. Most cases present with abdominal pain due to peptic ulceration and chronic diarrhoea not responding to general measures. The symptom complex is initially confused with other more common diseases, which lead to a delay in diagnosis. We present a rare case of a-12-year boy who initially presented with abdominal pain, diarrhoea, vomiting and progressive weight loss for over a two-year period before he was finally diagnosed as a case of ZES with the primary tumour in the pancreatic head and with multiple metastasis in both the liver and lymph nodes...
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28027325/using-a-novel-partitivirus-in-pseudogymnoascus-destructans-to-understand-the-epidemiology-of-white-nose-syndrome
#11
Vaskar Thapa, Gregory G Turner, Susan Hafenstein, Barrie E Overton, Karen J Vanderwolf, Marilyn J Roossinck
White-nose syndrome is one of the most lethal wildlife diseases, killing over 5 million North American bats since it was first reported in 2006. The causal agent of the disease is a psychrophilic filamentous fungus, Pseudogymnoascus destructans. The fungus is widely distributed in North America and Europe and has recently been found in some parts of Asia, but interestingly, no mass mortality is observed in European or Asian bats. Here we report a novel double-stranded RNA virus found in North American isolates of the fungus and show that the virus can be used as a tool to study the epidemiology of White-nose syndrome...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/28025118/detection-of-echinococcus-granulosus-and-echinococcus-ortleppi-in-bhutan
#12
Nirmal Kumar Thapa, Maria Teresa Armua-Fernandez, Dukpa Kinzang, Ratna B Gurung, Phuntsho Wangdi, Peter Deplazes
In this pilot study, fecal samples were collected from community dogs around slaughterhouses and from the city of Thimphu (n=138) as well as from carnivores in the forest area around a farm in Bhutan (n=28). Samples were analyzed microscopically for the presence of taeniid eggs by the floatation and sieving method. Further molecular analyses of 20 samples of community dogs positive for taeniid eggs confirmed 10 Echinococcus granulosus sensu lato and one Taenia hydatigena case. From 14 environmental fecal samples from the forest area positive for taeniid eggs, one contained E...
December 24, 2016: Parasitology International
https://www.readbyqxmd.com/read/27994400/in-vivo-confocal-microscopic-architecture-of-corneal-nerves-in-a-case-of-multiple-endocrine-neoplasia-type-2b
#13
Chintan Malhotra, Arun Kumar Jain, Bikram Thapa, Sabin Sahu
A detailed ocular examination and in vivo confocal microscopy (IVCM) using the Heidelberg retinal tomograph 3 with Rostock cornea module were performed in a patient with multiple endocrine neoplasia (MEN) 2b syndrome. Ocular findings included ptosis secondary to thickening of the lid margins, subconjunctival and perilimbal neuromas, and prominent corneal nerves extending up to the pupillary area. IVCM demonstrated structural alterations of both the main nerve trunks and the smaller branches. The main nerve trunks were grossly thickened while the smaller fibers were present in an intertwining manner in the anterior stroma...
October 2016: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/27993720/synergistic-anticancer-activity-of-combined-histone-deacetylase-and-proteasomal-inhibitor-loaded-zein-nanoparticles-in-metastatic-prostate-cancers
#14
Raj Kumar Thapa, Hanh Thuy Nguyen, Jee-Heon Jeong, Beom Soo Shin, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
The development of resistance and subsequent metastasis makes prostate cancer a leading cause of cancer-related death among men. Hence, nanoparticle-based combination chemotherapeutics could be a viable treatment strategy. We aimed to prepare vorinostat (Vor) and bortezomib (Bor) combination-loaded zein nanoparticles (ZNP, ZNP/VB) for treating metastatic prostate cancers. Our results revealed the successful preparation of ZNP/VB with a small particle size (~160nm) and polydispersity index (~0.20). Importantly, controlled and pH-dependent drug release profiles were observed...
December 18, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27992630/in-vivo-super-resolution-retinal-imaging-through-virtually-structured-detection
#15
Changgeng Liu, Yanan Zhi, Benquan Wang, Damber Thapa, Yanjun Chen, Minhaj Alam, Yiming Lu, Xincheng Yao
No abstract text is available yet for this article.
December 1, 2016: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/27957393/stress-responses-of-the-oil-producing-green-microalga-botryococcus-braunii-race-b
#16
Ivette Cornejo-Corona, Hem R Thapa, Daniel R Browne, Timothy P Devarenne, Edmundo Lozoya-Gloria
Plants react to biotic and abiotic stresses with a variety of responses including the production of reactive oxygen species (ROS), which may result in programmed cell death (PCD). The mechanisms underlying ROS production and PCD have not been well studied in microalgae. Here, we analyzed ROS accumulation, biomass accumulation, and hydrocarbon production in the colony-forming green microalga Botryococcus braunii in response to several stress inducers such as NaCl, NaHCO3, salicylic acid (SA), methyl jasmonate, and acetic acid...
2016: PeerJ
https://www.readbyqxmd.com/read/27942063/management-of-chronic-shoulder-pain-with-restricted-mobility-a-case-series
#17
Deepak Thapa, Vanita Ahuja, Deepanshu Dhiman
No abstract text is available yet for this article.
November 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27940443/women-s-health-is-not-in-focus-in-disaster-zones-lessons-from-the-nepal-earthquake
#18
EDITORIAL
Suraj B Thapa, Ganesh Acharya
No abstract text is available yet for this article.
December 9, 2016: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/27936247/land-use-and-socioeconomic-change-medicinal-plant-selection-and-biodiversity-resilience-in-far-western-nepal
#19
Ripu M Kunwar, Kedar Baral, Prashant Paudel, Ram P Acharya, Khum B Thapa-Magar, Mary Cameron, Rainer W Bussmann
Indigenous plant use-systems have evolved under, and constantly adapted to human and non-human impacts. In the last decades however, increasing socioeconomic and cultural transformations, including land-use change, outmigration, globalized markets, the introduction of new species, and climate change have led to a decreasing availability of indigenous resources, and are ultimately leading to a reduction of local use-knowledge. Participant observations, discussions, walks-in-the-woods, semi-structured interviews and informal meetings were carried out in 12 villages of far western Nepal between 2011 and 2015 to assess how sociocultural changes have affected the sustenance of indigenous systems and local biodiversity, when compared to studies carried out in the previous decades...
2016: PloS One
https://www.readbyqxmd.com/read/27935926/hyponatremia-in-patients-with-community-acquired-pneumonia
#20
L Karki, B Thapa, M K Sah
INTRODUCTION: Community acquired pneumonia is one the frequent cause of hospital admissions. Whereas, hyponatremia is a common electrolyte abnormality in hospitalized patients and has been shown to be associated with considerable morbidity and mortality. We aim to studyt the association of hyponatremia with community acquired pneumonia in terms of morbidity and mortality. METHODS: A prospective observational hospital based study was conducted in a hospital for a year...
April 2016: JNMA; Journal of the Nepal Medical Association
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