keyword
MENU ▼
Read by QxMD icon Read
search

docetaxel-induced polyploidy

keyword
https://www.readbyqxmd.com/read/24756365/anticancer-activity-of-the-aurora-a-kinase-inhibitor-mk-5108-in-non-small-cell-lung-cancer-nsclc-in-vitro-as-monotherapy-and-in-combination-with-chemotherapies
#1
Danielle C Chinn, William S Holland, Philip C Mack
PURPOSE: Aurora kinases are key regulators of mitotic events. Dysfunction of these kinases can cause polyploidy and chromosomal instability, a contributor to tumorigenesis. MK-5108 is a potent inhibitor of Aurora A kinase that has shown preclinical potent activity in malignancies of breast, cervical, colon, ovarian, and pancreatic origin. We sought to assess the preclinical efficacy of MK-5108 in a panel of non-small-cell lung cancer cell lines as a single agent and in combination with cisplatin and docetaxel...
July 2014: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/23990115/amg-900-a-small-molecule-inhibitor-of-aurora-kinases-potentiates-the-activity-of-microtubule-targeting-agents-in-human-metastatic-breast-cancer-models
#2
Tammy L Bush, Marc Payton, Scott Heller, Grace Chung, Kelly Hanestad, James B Rottman, Robert Loberg, Gregory Friberg, Richard L Kendall, Douglas Saffran, Robert Radinsky
Breast cancer is the most prevalent malignancy affecting women and ranks second in cancer-related deaths, in which death occurs primarily from metastatic disease. Triple-negative breast cancer (TNBC) is a more aggressive and metastatic subtype of breast cancer that is initially responsive to treatment of microtubule-targeting agents (MTA) such as taxanes. Recently, we reported the characterization of AMG 900, an orally bioavailable, potent, and highly selective pan-Aurora kinase inhibitor that is active in multidrug-resistant cell lines...
November 2013: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/22967442/-sensitivity-to-chemotherapeutic-drugs-of-polyploid-tumor-cells-induced-by-a-spindle-poison-nocodazole
#3
Juan Hao, Bi-bo Yuan, Yuan-fu Xu, Juan Yu, Guo-yan Liu, De-hua Wang
OBJECTIVE: To investigate the changes of drug sensitivity of spindle poison-induced polyploid tumor cells to chemotherapeutic agents and its possible mechanism. METHODS: Nocodazole in a dose of 100 ng/ml was used to induce polyploidization in a breast cancer cell line MDA-MB-231 cells. The polyploid cells (T-MDA-MB-231) were sorted by flow cytometry. The morphological changes and proliferation of T-MDA-MB-231 cells were compared with that of MDA-MB-231 cells. The cell growth inhibition was assessed by MTT assay...
June 2012: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/21291867/aurora-inhibitor-mln8237-in-combination-with-docetaxel-enhances-apoptosis-and-anti-tumor-activity-in-mantle-cell-lymphoma
#4
Wenqing Qi, Laurence S Cooke, Xiaobing Liu, Lisa Rimsza, Denise J Roe, Ann Manziolli, Daniel O Persky, Thomas P Miller, Daruka Mahadevan
Auroras (A and B) are oncogenic serine/threonine kinases that play key roles in the mitotic phase of the eukaryotic cell cycle. Analysis of the leukemia lymphoma molecular profiling project (LLMPP) database indicates Aurora over-expression correlates with poor prognosis. A tissue microarray (TMA) composed of 20 paired mantle cell lymphoma (MCL) patients demonstrated >75% of patients had high levels Aurora expression. Aurora A and B were also found elevated in 13 aggressive B-NHL cell lines. MLN8237, an Aurora inhibitor induced G2/M arrest with polyploidy and abrogated Aurora A and histone-H3 phosphorylation...
April 1, 2011: Biochemical Pharmacology
https://www.readbyqxmd.com/read/20515952/docetaxel-resistant-prostate-cancer-cells-remain-sensitive-to-s-trityl-l-cysteine-mediated-eg5-inhibition
#5
Carolyn Wiltshire, Babloo L Singh, Jacqueline Stockley, Janis Fleming, Brendan Doyle, Robert Barnetson, Craig N Robson, Frank Kozielski, Hing Y Leung
Castrate-resistant prostate cancer remains a major clinical challenge. Due to the toxicity profile of taxane-based chemotherapy and treatment failure in some patients, novel agents with improved efficacy to side effect profiles are urgently needed. Eg5, a member of the kinesin-5 family, controls the formation of the bipolar spindle during cell division, and suppressed Eg5 function leads to mitotic arrest. S-Trityl-L-cysteine (STLC) is a novel Eg5-specific small-molecule inhibitor. Here, we report the first study to evaluate its use in prostate cancer...
June 2010: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/10964328/comparison-of-2-methoxyestradiol-induced-docetaxel-induced-and-paclitaxel-induced-apoptosis-in-hepatoma-cells-and-its-correlation-with-reactive-oxygen-species
#6
H L Lin, T Y Liu, G Y Chau, W Y Lui, C W Chi
BACKGROUND: Previously, the authors observed that paclitaxel treatment of hepatoma cells resulted in differential cytotoxicity. Whether other antimicrotubule agents (docetaxel and 2-methoxyestradiol) are more effective than paclitaxel is not clear. Moreover, whether the modulation of reactive oxygen species (ROS) is involved in the drug-induced growth inhibition of hepatoma cells is not known. METHODS: The authors examined the effects of 2-methoxyestradiol, paclitaxel, and docetaxel on HepG2, Hep3B, HA22T/VGH, and Hepa1-6 hepatoma cell lines...
September 1, 2000: Cancer
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"