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hyperlipidemia and ischemic stroke

Samrat Yeramaneni, Dawn O Kleindorfer, Heidi Sucharew, Kathleen Alwell, Charles J Moomaw, Matthew L Flaherty, Daniel Woo, Opeolu Adeoye, Simona Ferioli, Felipe de Los Rios La Rosa, Sharyl Martini, Jason Mackey, Pooja Khatri, Brett M Kissela, Jane C Khoury
BACKGROUND: Although statin therapy is associated with reduced stroke and mortality risk, some studies report that higher lipid levels are associated with improved outcomes following ischemic stroke. AIMS: We examined the association of hyperlipidemia (HLD) combined with statin therapy on all-cause mortality in stroke patients. METHODS: All stroke patients in the Greater Cincinnati Northern Kentucky region of ∼1.3 million were identified using ICD-9 discharge codes in 2005 and 2010...
September 20, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
Aparna Pandey, Amit Shrivastava, Ashok Solanki
BACKGROUND: Stroke is one of the most frequent causes of death and disability worldwide and has significant clinical and socioeconomic impact. Hyperlipidemia and inflammation play major roles in atherothrombosis and in stroke. This study is conducted to compare the high sensitive C-reactive protein (hs-CRP) levels and the lipid profile parameters between stroke patients and control group and demonstrate correlation between markers, neurological deficit, and short-term outcome. METHODS: We have studied a total 162 patients according to inclusion criteria...
July 6, 2016: Iranian Journal of Neurology
Abdolhamid Shariat, Leila Niknam, Sadegh Izadi, Alireza Salehi
BACKGROUND: The aim of this study is to determine the frequency of intracranial artery stenosis in patients with acute ischemic stroke in Iran. METHODS: A total of 169 patients with acute ischemic stroke were eligible to participate and were enrolled in this study from January 2012 to February 2013. All the patients were admitted to the Nemazee ‎Hospital, affiliated to Shiraz University of Medical Sciences, Iran. They underwent transcranial Doppler (TCD) ultrasonography...
July 6, 2016: Iranian Journal of Neurology
Jasvinder A Singh, Shaohua Yu
BACKGROUND: Previous studies of allopurinol and stroke risk have provided contradictory findings, ranging from a protective effect to an increased risk. Our objective was to assess whether allopurinol use is associated with the risk of stroke in the elderly. METHODS: We used the 5 % random sample of Medicare beneficiaries from 2006-2012 to study the association of new allopurinol initiation and incident stroke. We used multivariable-adjusted Cox regression models adjusted for age, gender, race, Charlson index, and cardio-protective medications (beta-blockers, ACE inhibitors, diuretics, statins) to calculate hazards ratio (HR) with 95 % confidence intervals (CI)...
2016: BMC Neurology
Çiğdem Deniz, Yahya Çelik, Tuğçe Özdemir Gültekin, Gozde Eryiğit Baran, Çağla Deniz, Talip Asil
BACKGROUND AND PURPOSE: We aimed to examine the incidence of cognitive impairment among patients with stroke, the associated risk factors, progression of the cognitive impairment, and the association between the localization of the lesion(s) as detected by magnetic resonance imaging and the affected areas of cognitive function. METHODS: A total of 40 patients over 18 years of age enduring a transient ischemic stroke or minor stroke within the past 3 months who had a minimum life expectancy of 1 year were included in this study...
2016: Neuropsychiatric Disease and Treatment
Shu-Yu Tai, Ling-Feng Wang, Chih-Feng Tai, Yu-Ting Huang, Chen-Yu Chien
Few studies have investigated the relationship between chronic rhinosinusitis (CRS) and erectile dysfunction (ED). This case-control study aimed to investigate the association between CRS and the risk of ED in a large national sample. Tapping Taiwan's National Health Insurance Research Database, we identified people 30 years or older with a new primary diagnosis of CRS between 1996 and 2007. The cases were compared with sex- and age-matched controls. We identified 14 039 cases and recruited 140 387 matched controls...
2016: Scientific Reports
Kyeong Joon Kim, Jong-Min Kim, Yun Jung Bae, Hee Joon Bae, Beomseok Jeon, Jae Hyung Kim, Jeong Ho Han, Chang Wan Oh
BACKGROUND: Hemifacial spasm (HFS) is frequently caused by vascular compression of the facial nerve. Vertebrobasilar dolichoectasia (VBDE) may cause vascular crowding in the limited space of the posterior fossa, increasing the chance of vascular compression of the facial nerve. We investigated the prevalence of VBDE in HFS. METHODS: We analyzed the presence of VBDE on 3.0 T magnetic resonance images in patients with HFS and control subjects; age, sex and hypertension were matched...
August 20, 2016: Parkinsonism & related Disorders
Ahsan Mukhtar, Sidra Malik, Muhammad Saim Khan, Mazhar Ishaq
Retinal artery occlusion is an uncommon condition but can lead to grave consequences if not managed in time. Elderly population with other comorbid conditions like hypertension, ischemic heart disease, hyperlipidemia and stroke are commonly affected. However, this condition may affect younger population with entirely different systemic associations. Thromboembolism, which usually takes place secondary to cardiac emboli or hypercoagulable states cause retinal artery occlusion in young population. A24-year lady presented with a short history of unilateral altitudinal visual loss...
July 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Xiaojian Wang, Ling Zhu, Yan Wu, Kai Sun, Ming Su, Liping Yu, Jingzhou Chen, Weiju Li, Jing Yang, Zuyi Yuan, Rutai Hui
Growth differentiation factor 15 (GDF-15) is a relatively new biomarker that predicts adverse stroke outcomes. However, the association of GDF-15 with first-ever stroke in hypertensive patients has not yet been evaluated. The objective of this study was to evaluate the clinical implications of plasma GDF-15 on the development of first-ever stroke in patients with hypertension.In total, 254 patients with hypertension without a history of stroke were included from March 2010 to August 2010 and followed up until June 2013...
July 2016: Medicine (Baltimore)
Haralampos Milionis, Fotios Barkas, George Ntaios, Vasileios Papavasileiou, Kostantinos Vemmos, Patrick Michel, Moses Elisaf
BACKGROUND/PURPOSE: A reduction of cardiovascular events has been reported in phase 2 and 3 trials of the proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors alirocumab and evolocumab. We aimed to investigate the effect PCSK9 inhibition on stroke risk in a meta-analysis involving data from randomized studies with alirocumab and evolocumab. METHODS: Data from pre-specified combined analysis of 4465 patients who completed phase 2 or 3 studies of evolocumab over a period of 1year and a randomized trial on alirocumab including 2341 patients with hyperlipidemia on maximally tolerated statin who were at high risk for coronary heart disease over a period of 1...
June 28, 2016: European Journal of Internal Medicine
Azra Zafar, Fahd A Al-Khamis, Aishah I Al-Bakr, Abdulla A Alsulaiman, Amir H Msmar
OBJECTIVE: To identify the different subtypes of acute ischemic stroke, and estimate the frequency of various risk factors among these patients. METHODS: In this retrospective, cross-sectional study, we reviewed the medical records of patients admitted with the diagnosis of acute ischemic stroke at King Fahd Hospital of the University, Al-Khobar, Saudi Arabia from March 2008 till December 2015. The demographic characteristics, subtypes of stroke, risk factors (hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, atrial fibrillation, valvular heart disease) and other relevant data were documented on pre-defined data sheets...
July 2016: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Teresa M Damush, Laura Myers, Jane A Anderson, Zhangsheng Yu, Susan Ofner, Gloria Nicholas, Barbara Kimmel, Arlene A Schmid, Thomas Kent, Linda S Williams
We targeted stroke/transient ischemic attack (TIA) survivors to engage in self-management practices to manage secondary stroke risk factors. We conducted a randomized, regional pilot trial of a locally adapted, secondary stroke prevention program. We implemented the program at two Veterans Administration Medical Centers. Program sessions targeted stroke risk factor self-management. Specifically, we evaluated the effect of the program on the reach, implementation, and effectiveness on patient self-efficacy; stroke-specific, health-related quality of life; and medication adherence for the prevalent stroke risk factors: (1) diabetes, (2) hypertension, and (3) hyperlipidemia...
September 2016: Translational Behavioral Medicine
Yeon Suk Jung, Jung Hwa Park, Hyunha Kim, So Young Kim, Ji Young Hwang, Ki Whan Hong, Sun Sik Bae, Byung Tae Choi, Sae-Won Lee, Hwa Kyoung Shin
AIM: Increasing evidence suggests that probucol, a lipid-lowering agent with anti-oxidant activities, may be useful for the treatment of ischemic stroke with hyperlipidemia via reduction in cholesterol and neuroinflammation. In this study we examined whether probucol could protect against brain ischemic injury via anti-neuroinflammatory action in normal and hyperlipidemic mice. METHODS: Primary mouse microglia and murine BV2 microglia were exposed to lipopolysaccharide (LPS) for 3 h, and the release NO, PGE2, IL-1β and IL-6, as well as the changes in NF-κB, MAPK and AP-1 signaling pathways were assessed...
August 2016: Acta Pharmacologica Sinica
Binbin Sun, Shuangyi Fan, Zhifang Li, Wanshen Guo, Lixue Liu, Youping Zhou, Luyan Ji, Leshi Zhang, Xusheng Huang
BACKGROUND: The occurrence of acute ischemic stroke in cancer patients is not unusual. In clinical practice, acute ischemic stroke with cancer usually cannot be diagnosed promptly due to lack of specific markers. But for cancer patients, advanced prevention, accurate diagnosis and proper treatment of acute ischemic stroke are very important. The aim of the present study was to investigate the clinical and neuroimaging features of acute ischemic stroke in patients with cancer. METHODS: We conducted a retrospective review of all cancer-associated acute ischemic stroke patients (n = 46) admitted to the Affiliated Hospital of Academy of Military Medical Sciences between October 2011 and March 2015...
2016: European Neurology
Tain-Junn Cheng, How-Ran Guo, Chia-Yu Chang, Shih-Feng Weng, Pi-I Li, Jhi-Joung Wang, Wen-Shiann Wu
Stroke is a common cause of death worldwide, but about 30% of ischemic stroke (IS) patients have no identifiable contributing risk factors. Because peptic ulcer disease (PUD) and vascular events share some common risk factors, we conducted a population-based study to evaluate the association between PUD and IS.We followed up a representative sample of 1 million residents of Taiwan using the National Health Insurance Research Database from 1997 to 2011. We defined patients who received medications for PUD and had related diagnosis codes as the PUD group, and a reference group matched by age and sex was sampled from those who did not have PUD...
May 2016: Medicine (Baltimore)
Monica Reed Chase, Howard S Friedman, Prakash Navaratnam, Kim Heithoff, Ross J Simpson
BACKGROUND: There is growing concern about appropriate disease management for peripheral artery disease (PAD) because of the rapidly expanding population at risk for PAD and the high burden of illness associated with symptomatic PAD. A better understanding of the potential economic impact of symptomatic PAD relative to a matched control population may help improve care management for these patients. OBJECTIVE: To compare the medical resource utilization, costs, and medication use for patients with symptomatic PAD relative to a matched control population...
June 2016: Journal of Managed Care & Specialty Pharmacy
Tae Jung Kim, Sang-Bae Ko, Han-Gil Jeong, Ji Sung Lee, Chi Kyung Kim, Yerim Kim, Kiwoong Nam, Heejung Mo, Sang Joon An, Huimahn Alex Choi, Byung-Woo Yoon
BACKGROUND AND PURPOSE: Wake-up stroke (WUS) represents a quarter of all ischemic strokes and may be a specific subgroup. Nocturnal desaturation secondary to sleep-disordered breathing is an independent risk factor for stroke, but the association between nocturnal desaturation and WUS remains unclear. We investigated the relationship between nocturnal desaturation using oxygen desaturation index and WUS in patients with acute stroke in the stroke unit. METHODS: A total of 298 patients admitted for acute ischemic stroke to the stroke unit between July 2013 and May 2015 were enrolled...
July 2016: Stroke; a Journal of Cerebral Circulation
Khaled Hammoud, Michael Lanfranchi, Sean X Li, William A Mehan
The diagnostic value of head magnetic resonance imaging after negative head computed tomography for emergency department patients with vague neurologic symptoms, such as dizziness and altered mental status, remains an ongoing discussion. The objective of this study is to detect the subgroup of patients with such presentations having minor strokes whom may benefit from primary and secondary stroke prevention. We conducted a retrospective analysis and stratified patient risk factors associated with positive findings on subsequent head MRI ordered by the emergency department physician following a normal head CT...
August 2016: Emergency Radiology
Kathie P Huang, Cara J Joyce, Maxim Topaz, Ye Guo, Arash Mostaghimi
BACKGROUND: The cardiovascular risk of patients with alopecia areata (AA) is not well characterized, with limited studies evaluating the risk of acute myocardial infarction (AMI) and ischemic stroke. OBJECTIVE: We sought to determine the risk for patients with AA to develop subsequent stroke and AMI. METHODS: We conducted propensity-matched retrospective analysis between January 1, 2000, and January 1, 2010, from Brigham and Women's Hospital and Massachusetts General Hospital in Boston, MA...
July 2016: Journal of the American Academy of Dermatology
Bogusław Okopień, Łukasz Bułdak, Aleksandra Bołdys
Atherosclerosis is an inflammatory disease that affects arterial wall. It leads to wall thickening and its instability. As a result a reduction in lumen diameter and blood flow is observed. This manifests predominantly as the affectation of vascular bed of coronary (myocardial infarction), cerebral, carotid (ischemic stroke) or peripheral arteries (limb amputation). One of the most important factors that accelerate atherosclerosis is hyperlipidemia. According to current guidelines the main attention should be focused on the treatment of hyperlipidemia (beside the prevention, which includes proper diet, physical activity and risk factors avoidance)...
August 2016: Pharmacological Reports: PR
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