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early gastriccancer

Zhaode Bu, Jiafu Ji
Gastric cancer remains one of the most common types of cancer worldwide, and most patients present withadvanced disease. Sixty percent of these patients eventually relapse after curative surgical resection, and combinationchemotherapy regimens only provide limited survival benefits. Mammalian target of rapamycin (mTOR) is a new targetof cancer therapies. Preclinical data suggest that the suppression of the mTOR pathway inhibits the progression of gastriccancer in vitro and in animal models. In clinical trials, the mTOR inhibitor, everolimus, was well tolerated in phase I/IIstudies on patients with metastatic gastric cancer...
February 2013: Current Cancer Drug Targets
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