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https://www.readbyqxmd.com/read/29785359/white-matter-microstructure-white-matter-lesions-and-hypertension-an-examination-of-early-surrogate-markers-of-vascular-related-brain-change-in-midlife
#1
Thaddeus Haight, R Nick Bryan, Guray Erus, Meng-Kang Hsieh, Christos Davatzikos, Ilya Nasrallah, Mark D'Esposito, David R Jacobs, Cora Lewis, Pamela Schreiner, Stephen Sidney, Osorio Meirelles, Lenore J Launer
Objective: We examined imaging surrogates of white matter microstructural abnormalities which may precede white matter lesions (WML) and represent a relevant marker of cerebrovascular injury in adults in midlife. Methods: In 698 community-dwelling adults (mean age 50 years ±3.5 SD) from the Coronary Artery Risk Development in Young Adults (CARDIA) Brain MRI sub-study, WML were identified on structural MR and fractional anisotropy (FA), representing WM microstructural integrity, was derived using Diffusion Tensor Imaging...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29774939/-feasibility-and-preliminary-technical-experience-of-single-incision-plus-one-port-laparoscopic-total-gastrectomy-combined-with-%C3%AF-shaped-esophagojejunal-anastomosis-in-surgical-treatment-of-gastric-cancer
#2
Guangsheng Du, Enlai Jiang, Yuan Qiu, Wensheng Wang, Shuai Wang, Yunbo Li, Ke Peng, Xiang Li, Hua Yang, Weidong Xiao
OBJECTIVE: To explore the feasibility, safety, and preliminary technical experience of single incision plus one port laparoscopic total gastrectomy combined with π-shaped esophagojejunal anastomosis (SILT-π) in the surgical treatment of gastric cancer. METHODS: Clinical data of 5 gastric cancer patients undergoing SILT-π operation at the Department of General Surgery, The Second Affiliated Hospital of the Army Medical University from August to October 2017 were retrospectively analyzed...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29768377/occurrence-of-metachronous-multiple-primary-cancers-occurred-in-different-parts-of-the-stomach-with-2-pathologic-features-a-case-report
#3
Yan Song, Ningning Zhao, Kui Jiang, Zhongqing Zheng, Bangmao Wang, Dalu Kong, Shu Li
RATIONALE: With the increasing survival rate of gastric cancer, more multiple primary cancers (MPC) have been reported. However, few cases involve metachronous multiple primary cancers which both occurred in the stomach. PATIENT CONCERNS: An 83-year-old Chinese male had been diagnosed with gastric cardia cancer and underwent proximal gastrectomy. The pathological result was gastric adenocarcinoma. 13 years later the patient's gastroscope result deteriorated. The biopsy of the antrum revealed dysplasia with doubtful focal cancerization...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29766708/axillary-extramammary-paget-s-disease-on-lymphadenectomy-scar-for-melanoma-an-instance-of-immunocompromised-district
#4
Roberta Giuffrida, Francesco Borgia, Maria Lentini, Roberta Cardia, Serafinella P Cannavò
No abstract text is available yet for this article.
June 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29766515/results-of-pneumatic-dilation-in-treating-achalasia-predictive-factors
#5
REVIEW
Valter Nilton Felix
Forced pneumatic dilatation (PD) of the cardia is one of the most consecrated therapeutic measures for esophageal achalasia. The procedure only achieved better standardization with the appearance of the Rigiflex balloon. Results and predictive factors of success and failure of PD are reviewed, right after the description of the main technical aspects of the procedure. The success rates, providing control of dysphagia for about 1 year from the procedure using the Rigiflex balloon, are quite satisfactory, with success in more than 75% of patients...
May 16, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29765447/microrna-141-inhibits-proliferation-of-gastric-cardia-adenocarcinoma-by-targeting-macc1
#6
Shubin Li, Jixian Zhu, Junjie Li, Shubo Li, Bin Li
Introduction: Abnormal expression of microRNAs (miRNAs) contributes to cancer development through regulating proliferation, apoptosis and drug resistance in cancer cells. The present study was designed to explore the effect and mechanism of miR-141 on gastric cardia adenocarcinoma (GCA). Material and methods: Forty-one paired GCA tissues and adjacent normal tissues were obtained from GCA patients never treated by chemotherapy or radiotherapy. QRT-PCR was used to detect the expression level of miR-141 in GCA...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29743918/effect-of-lavender-lavandula-angustifolia-essential-oil-on-acute-inflammatory-response
#7
Gabriel Fernando Esteves Cardia, Saulo Euclides Silva-Filho, Expedito Leite Silva, Nancy Sayuri Uchida, Heitor Augusto Otaviano Cavalcante, Larissa Laila Cassarotti, Valter Eduardo Cocco Salvadego, Ricardo Alexandre Spironello, Ciomar Aparecida Bersani-Amado, Roberto Kenji Nakamura Cuman
Lavandula angustifolia is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29743108/-18-fdg-pet-ct-identifies-histopathological-non-responders-after-neoadjuvant-chemotherapy-in-locally-advanced-gastric-and-cardia-cancer-cohort-study
#8
Paul M Schneider, Dilmurodjon Eshmuminov, Tamara Rordorf, Diana Vetter, Patrick Veit-Haibach, Achim Weber, Peter Bauerfeind, Panagiotis Samaras, Kuno Lehmann
BACKGROUND: Pathologic response to neoadjuvant chemotherapy (neoCTX) is a prognostic factor in many cancer types, and early prediction would help to modify treatment. In patients with gastric and esophagogastric junction (AEG) cancer, the accuracy of FDG PET-CT to predict early pathologic response after neoadjuvant chemotherapy (neoCTX) is currently not known. METHODS: From a consecutive cohort of 72 patients, 44 patients with resectable, locally-advanced gastric cancer or AEG Siewert type II and III received neoCTX after primary staging with endoscopic ultrasound, PET-CT and laparoscopy...
May 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29738331/intraoperative-3-dimensional-transesophageal-echocardiography-assessment-of-valvular-geometry-after-implantation-of-basal-annuloplasty-of-cardia-externally-device-for-ischemic-mitral-regurgitation
#9
https://www.readbyqxmd.com/read/29735485/longitudinal-associations-of-smoke-free-policies-and-incident-cardiovascular-disease-cardia-study
#10
Stephanie L Mayne, Rachel Widome, Allison J Carroll, Pamela J Schreiner, Penny Gordon-Larsen, David R Jacobs, Kiarri N Kershaw
Background -Smoke-free legislation has been associated with lower rates of cardiovascular disease hospital admissions in ecological studies. However, prior studies lacked detailed information on individual-level factors (eg, sociodemographic and clinical characteristics) that could potentially confound associations. Our objective was to estimate associations of smoke-free policies with incident cardiovascular disease in a longitudinal cohort after controlling for sociodemographics, cardiovascular disease risk factors, and policy covariates...
May 7, 2018: Circulation
https://www.readbyqxmd.com/read/29732464/immunohistochemical-study-on-dystrophin-expression-in-cad-related-sudden-cardiac-death-a-marker-of-early-myocardial-ischaemia
#11
Cristina Mondello, Luigi Cardia, Giovanni Bartoloni, Alessio Asmundo, Elvira Ventura Spagnolo
The aims of this study were to assess if dystrophin can be a tool for the forensic evaluation of sudden cardiac death due to coronary atherosclerotic disease (CAD) and particularly if it can be a marker of early myocardial ischaemia. Then in this investigation, the dystrophin was compared to C5b-9 and fibronectin to analyze if there are some differences in the expression of these proteins. Two groups of CAD-related sudden cardiac death, respectively the group 1 with gross and/or histological evidence and the group 2 with no specific histological signs of myocardial ischaemia were used...
May 7, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29719284/characterization-of-helicobacter-pylori-na%C3%A3-ve-early-gastric-cancers
#12
Akihiro Yamada, Mitsuru Kaise, Naoko Inoshita, Takahito Toba, Kosuke Nomura, Yasutaka Kuribayashi, Satoshi Yamashita, Tsukasa Furuhata, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani, Osamu Ogawa, Toshiro Iizuka, Shu Hoteya
AIM: Helicobacter pylori-naïve gastric cancers(GCs) have not been well documented. We aimed to characterize early H. pylori-naïve GCs. SUBJECTS AND METHODS: Of 666 patients with GC resected by endoscopic submucosal dissection, H. pylori-naïve patients were extracted according to the definition: no H. pylori eradication history, negative for serum H. pylori-antibody and current H. pylori-infection tests, and no gastric atrophy by pepsinogen (PG) test, endoscopy, and histology...
May 2, 2018: Digestion
https://www.readbyqxmd.com/read/29712737/fgf23-fibroblast-growth-factor-23-and-incident-hypertension-in-young-and-middle-aged-adults-the-cardia-study-coronary-artery-risk-development-in-young-adults
#13
Ehimare Akhabue, Samantha Montag, Jared P Reis, Lindsay R Pool, Rupal Mehta, Clyde W Yancy, Lihui Zhao, Myles Wolf, Orlando M Gutierrez, Mercedes R Carnethon, Tamara Isakova
Blacks have the highest prevalence of hypertension in the United States. Higher levels of FGF23 (fibroblast growth factor-23) have been associated with worse cardiovascular outcomes. Whether FGF23 is associated with rising blood pressure (BP) and racial differences in incident hypertension is unclear. We studied 1758 adults (45.0±3.7 years; 57.8% female; 36.9% black) without hypertension or cardiovascular disease who participated in the year 20 (2005-2006) follow-up examination of the CARDIA study (Coronary Artery Risk Development in Young Adults)...
April 30, 2018: Hypertension
https://www.readbyqxmd.com/read/29708994/profiles-of-patient-and-tumour-characteristics-in-relation-to-health-related-quality-of-life-after-oesophageal-cancer-surgery
#14
Poorna Anandavadivelan, Anna Wikman, Asif Johar, Pernilla Lagergren
Strong deterioration in health-related quality of life (HRQOL) is a major concern in a sub-group of long-term oesophageal cancer survivors. This study aimed to identify potential clustering of patients and tumour variables that predicts such deterioration. Patient and tumour variables were collected in a prospective cohort of patients who underwent surgery for oesophageal cancer in Sweden 2001-2005. Latent cluster analysis identified statistically significant clustering of these variables. Multivariable logistic regression adjusted for age, BMI, tumour stage and marital status was used to determine odds ratios (ORs) with 95% confidence intervals (CIs) between patient profiles and HRQOL at 3 and 5 years from surgery...
2018: PloS One
https://www.readbyqxmd.com/read/29707766/risk-of-gastric-cancer-among-patients-with-gastric-intestinal-metaplasia
#15
Liming Shao, Peiwei Li, Jun Ye, Jiamin Chen, Yuehua Han, Jianting Cai, Xinliang Lu
Plenty of studies have assessed the association between intestinal metaplasia (IM) and gastric cancer risk, while the results were inconsistent. We aimed to assess the risk of gastric cancer among patients with IM. Systematic literature searches were conducted in PubMed, Embase and Cochrane databases. Baseline characteristics and outcomes from the included studies were extracted independently by two investigators. Either a fixed-effects or a random-effects model was used to composite the pooled OR for gastric cancer risk...
April 29, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29707312/establishment-of-animal-model-of-gastroesophageal-reflux-disease-by-per-oral-endoscopic-tunneling-a-preliminary-study
#16
Hai-Qing Hu, Hui-Kai Li, Ying Xiong, Xiao-Bin Zhang, Jun-Li Zhi, Xiao-Xiao Wang, En-Qiang Linghu
Background: Although a variety of antireflux procedures and medications are used to treat gastroesophageal reflux disease (GERD), reliable large-animal models of GERD that can be used to objectively compare the efficacy of these treatments are lacking. We developed a method to establish large animal models of GERD by endoscopic sphincterotomy to develop an endoscopic treatment for GERD. Methods: In this study six flesh swine carcasses were used. A full thickness incision was made at the esophageal site 5 cm above the dentate line by per-oral endoscopic tunneling...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29696226/where-are-they-now-retention-strategies-over-25-years-in-the-coronary-artery-risk-development-in-young-adults-cardia-study
#17
Ellen Funkhouser, Jennifer Wammack, Cathy Roche, Jared Reis, Stephen Sidney, Pamela Schreiner
Purpose: In 1991, we described the recruitment and goals for a cohort of young adults. At the time, little was known about long-term retention of young, healthy and mobile adults or minorities. We present retention strategies and rates over 25 years, and predictors of participation at the year 25 follow-up examination of the Coronary Artery Risk Development in Young Adults (CARDIA) Study, a longitudinal investigation of coronary artery disease risk factors in a biracial population initially ages 18-30 years recruited from four U...
March 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29692806/endoscopic-submucosal-tunnel-dissection-for-large-gastric-neoplastic-lesions-a-case-matched-controlled-study
#18
Xiuxue Feng, Enqiang Linghu, Ningli Chai, Zhongsheng Lu, Xiangdong Wang, Ping Tang, Jiangyun Meng, Hong Du, Hongbin Wang
Aim: To evaluate the efficacy and safety of endoscopic submucosal tunnel dissection (ESTD) for resection of large superficial gastric lesions (SGLs). Methods: The clinicopathological records of patients performed with ESTD or endoscopic submucosal dissection (ESD) for SGLs between January 2012 and January 2014 were retrospectively reviewed. 7 cases undergoing ESTD were enrolled to form the ESTD group. The cases were individually matched at a 1 : 1 ratio to other patients performed with ESD according to lesion location, ulcer or scar findings, resected specimen area, operation time and operators, and the matched cases constituting the ESD group...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29683186/morbidity-and-mortality-according-to-age-following-gastrectomy-for-gastric-cancer
#19
S D Nelen, K Bosscha, V E P P Lemmens, H H Hartgrink, R H A Verhoeven, J H W de Wilt
BACKGROUND: This study investigated age-related differences in surgically treated patients with gastric cancer, and aimed to identify factors associated with outcome. METHODS: Data from the Dutch Upper Gastrointestinal Cancer Audit were used. All patients with non-cardia gastric cancer registered between 2011 and 2015 who underwent surgery were selected. Patients were analysed by age group (less than 70 years versus 70 years or more). Multivariable logistic regression was used to assess the influence of clinicopathological factors on morbidity and mortality...
April 23, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29675663/origins-of-metaplasia-in-barrett-s-esophagus-is-this-an-esophageal-stem-or-progenitor-cell-disease
#20
REVIEW
Wei Zhang, David H Wang
The incidence of esophageal adenocarcinoma has been increasing in Western countries over the past several decades. Though Barrett's esophagus, in which the normal esophageal squamous epithelium is replaced with metaplastic intestinalized columnar cells due to chronic damage from gastroesophageal reflux, is accepted as the requisite precursor lesion for esophageal adenocarcinoma, the Barrett's esophagus cell of origin and the molecular mechanism underlying esophageal epithelial metaplasia remain controversial...
April 19, 2018: Digestive Diseases and Sciences
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