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https://www.readbyqxmd.com/read/28345805/promoter-hypermethylation-mediated-downregulation-of-mir-770-and-its-host-gene-meg3-a-long-non-coding-rna-in-the-development-of-gastric-cardia-adenocarcinoma
#1
Wei Guo, Zhiming Dong, Shengnan Liu, Yiling Qiao, Gang Kuang, Yanli Guo, Supeng Shen, Jia Liang
Maternally expressed gene 3 (MEG3) is an imprinted gene located at 14q32 which encodes an lncRNA and is downregulated in an expanding list of cancer cell lines and primary human cancers. The miR-770 is transcribed from the intronic sequence of MEG3 and MEG3 may be the host gene for miR-770. However, the biological role of MEG3 and miR-770 in gastric cardia adenocarcinoma (GCA) development and prognosis is poorly defined. The present study was to investigate the function and methylation status of MEG3 in GCA, and further to detect the functional association of miR-770 and its host gene MEG3 in GCA carcinogenesis and prognosis...
March 27, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28338726/cumulative-exposure-to-systolic-blood-pressure-during-young-adulthood-through-midlife-and-the-urine-albumin-to-creatinine-ratio-at-midlife
#2
Holly Kramer, Laura Colangelo, Cora E Lewis, David R Jacobs, Mark Pletcher, Kirstin Bibbins-Domingo, Alex Chang, David Siscovick, Michael Shlipak, Carmen A Peralta, Nisha Bansal, Paul Muntner, Kiang Liu
BACKGROUND: Higher blood pressure during young adulthood may increase cardiovascular and kidney disease risk later in life. This study examined the association of cumulative systolic blood pressure (SBP) exposure during young adulthood through midlife with urine albumin-to-creatinine ratios (ACR) measured during midlife. METHODS: We used data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a biracial cohort recruited in 4 urban areas during years 1985-1986...
February 21, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28336766/abdominal-obesity-and-gastroesophageal-cancer-risk-systematic-review-and-meta-analysis-of-prospective-studies
#3
Xuan Du, Khemayanto Hidayat, Bi-Min Shi
Objective: To systematically and quantitatively review the relation of abdominal obesity, as measured by waist circumference (WC) and waist to hip ratio (WHR), to total gastroesophageal cancer, gastric cancer and esophageal cancer.  Methods: PubMed and Web of Science databases were searched for studies assessing the association between abdominal obesity and gastroesophageal cancer up to August 2016. A random-effect model was used to calculate the summary relative risks (RRs) and 95% confidence intervals (CIs)...
March 23, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28335098/endoscopic-submucosal-tunnel-dissection-for-upper-gastrointestinal-submucosal-tumors-originating-from-the-muscularis-propria-layer-a-single-center-study
#4
Xiaowei Tang, Yutang Ren, Silin Huang, Qiaoping Gao, Jieqiong Zhou, Zhengjie Wei, Bo Jiang, Wei Gong
Background/Aims: In recent years, endoscopic submucosal tunnel dissection (ESTD) has gained popularity worldwide. The aim of this study was to evaluate the safety and efficacy of ESTD in treating upper gastrointestinal submucosal tumors (SMTs) in a large-volume endoscopic center. Methods: Patients with SMTs were enrolled in this study between January 2012 and January 2015. Demographic data, clinical data, and treatment outcome were collected and analyzed. Results: Seventy SMTs originating from the muscularis propria (MP) layer were identified in 69 patients...
March 24, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28325198/the-evaluation-and-management-of-suspicious-gastric-lesions-following-bariatric-surgery
#5
REVIEW
Guillermo Gomez
Obesity has reached epidemic proportions worldwide and is associated with a higher mortality from several diseases, including adenocarcinoma of the esophagus and of the gastric cardia. Increased body mass index is associated with an increased incidence of gastroesophageal reflux disease (GERD), Barrett metaplasia, and adenocarcinoma of the cardia. Bariatric surgery remains the most effective therapy for morbid obesity and has the potential to improve weight-related GERD. A high index of suspicion is paramount for early detection of foregut neoplasia after bariatric surgery...
April 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28321165/fibrin-sealant-for-closure-of-mucosal-penetration-at-the-cardia-during-peroral-endoscopic-myotomy-a-retrospective-study-at-a-single-center
#6
Wen-Gang Zhang, En-Qiang Linghu, Hui-Kai Li
AIM: To assess the efficacy and safety of fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy (POEM). METHODS: Twenty-four patients who underwent POEM and experienced mucosal injury of the cardia during the procedure were retrospectively identified. Of the 24 patients, 21 had mucosal penetration and 3 had only slight mucosal damage without penetration. The 21 patients with mucosal penetration received fibrin sealant for closure at the site of penetration...
March 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28319273/gastric-microbiota-features-associated-with-cancer-risk-factors-and-clinical-outcomes-a-pilot-study-in-gastric-cardia-cancer-patients-from-shanxi-china
#7
Guoqin Yu, Nan Hu, Lemin Wang, Chaoyu Wang, Xiao-You Han, Mike Humphry, Jacques Ravel, Christian C Abnet, Philip R Taylor, Alisa M Goldstein
Little is known about the link between gastric microbiota and the epidemiology of gastric cancer. In order to determine the epidemiologic and clinical relevance of gastric microbiota, we used 16S ribosomal RNA gene sequencing analysis to characterize the composition and structure of the gastric microbial community of 80 paired samples (non-malignant and matched tumor tissues) from gastric cardia adenocarcinoma (GCA) patients in Shanxi, China. We also used PICRUSt to predict microbial functional profiles. Compared to patients without family history of upper gastrointestinal (UGI) cancer in the non-malignant gastric tissue microbiota, patients with family history of UGI cancer had higher Helicobacter pylori (Hp) relative abundance (median: 0...
March 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28316765/five-year-survival-rate-for-gastric-cancer-in-yazd-province-central-iran-from-2001-to-2008
#8
Mohsen Akhondi-Meybodi, Marzieh Ghane, Sara Akhondi-Meybodi, Golnaz Dashti
BACKGROUND The number of patients with gastric cancer is growing worldwide. In Iran (in 2009) of 74067 new cases of cancer, 6886 were diagnosed as having gastric cancer. This study was conducted to investigate 5-year survival rate for gastric cancer in Yazd province, central Iran. METHODS In this descriptive study, the medical records of patients with gastric cancer were collected from the archives of Yazd hospitals from 2001 to 2008. The data gathered included age, sex, type of histopathology, site of involvement, cancer staging, and mode of treatment, which were analyzed using SPSS software version 11...
January 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28316620/clinical-outcomes-and-safety-of-partial-full-thickness-myotomy-versus-circular-muscle-myotomy-in-peroral-endoscopic-myotomy-for-achalasia-patients
#9
Chenyu Li, Aixia Gong, Jingwen Zhang, Zhijun Duan, Linmei Ge, Nan Xia, Jing Leng, Mei Li, Yanjie Liu
Background. Here we aimed to evaluate and compare the efficacy and safety between partial full-thickness myotomy and circular muscle myotomy during POEM procedure in achalasia patients. Methods. Clinical data of achalasia of cardia (AC) patients who underwent POEM in our center during January 2014 to January 2015 was collected (34 cases). 19 patients who received partial full-thickness myotomy were assigned to group A and 14 patients who received circular muscle myotomy were assigned to group B. The procedure-related parameters between the two groups were compared...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28303873/-transhiatal-esophagectomy-for-cardia-and-esophagus-cancer
#10
A Yu Moiseev, A M Shulutko, S E Gryaznov
AIM: To present the result of transhiatal esophagectomies with simultaneous repair. MATERIAL AND METHODS: The study included 67 procedures. In 35 cases surgery was carried out for adenocarcinoma of distal esophagus or cardia with high transition to esophagus, in 32 cases - for epidermal carcinoma of the esophagus. Gastric graft and left half of the colon were used in 60 and 7 cases respectively for simultaneous repair. 29 patients underwent transhiatal instrumental esophagectomy using author's original technique...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28299508/prognostic-role-of-primary-tumor-location-in-non-metastatic-gastric-cancer-a-systematic-review-and-meta-analysis-of-50-studies
#11
REVIEW
Fausto Petrelli, Michele Ghidini, Sandro Barni, Francesca Steccanella, Giovanni Sgroi, Rodolfo Passalacqua, Gianluca Tomasello
INTRODUCTION: The incidence of gastric cancer (GC) arising in the upper third of the stomach, including the cardia or gastroesophageal junction (GEJ), has increased in the last decades due to established etiological risk factors such as diet, obesity, and gastroesophageal reflux. We conducted a systematic review and meta-analysis to determine the prognostic role of site of origin in patients with proximal versus distal GC. MATERIAL AND METHODS: We conducted a search of the PubMed, Cochrane Library, SCOPUS, Web of Science, EMBASE, Google Scholar, LILACS, and CINAHL databases from inception to September 2016...
March 15, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28298742/indications-for-magnetic-resonance-imaging-of-the-female-pelvis-at-a-referral-center-for-cancer
#12
EDITORIAL
Patrícia Prando Cardia
No abstract text is available yet for this article.
January 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28294664/-a-giant-inflammatory-fibroid-polyp-of-the-esophagus
#13
Balázs Vincze, Péter Mezei, János Hanyik, Sándor Almássy, Károly Gyáni, Géza Szűcs, Imre Tóth
Inflammatory fibroid polyp (IFP) is an uncommon benign tumor of the gastrointestinal tract. IFP in the esophagus is very rare, in particular in giant size. A case of a 63 year old woman with a 13 × 7 × 4.5 cm polyp originated of the lower third of the oesophagus is presented. Her esophageal polyp extended proximally from the level of the tracheal bifurcation, prolapsing through the cardia as well as the herniated stomach, and entered distally into the abdominal part of the stomach. Resection of the polyp was performed via a right oesophago-gastrotomy...
March 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28293089/prognostic-significance-of-preoperative-and-postoperative-ck19-and-cea-mrna-levels-in-peripheral-blood-of-patients-with-gastric-cardia-cancer
#14
Yu-Feng Qiao, Chuan-Gui Chen, Jie Yue, Ming-Quan Ma, Zhao Ma, Zhen-Tao Yu
AIM: To evaluate the clinical and prognostic significance of preoperative and postoperative cytokeratin 19 (CK19) and carcinoembryonic antigen (CEA) mRNA levels in peripheral blood of patients with gastric cardia cancer (GCC). METHODS: We detected the preoperative and postoperative mRNA levels of CK19 and CEA in peripheral blood of 129 GCC patients by using reverse transcription-polymerase chain reaction and evaluated their clinical and prognostic significance by univariate Kaplan-Meier survival analysis and multivariate Cox proportional hazard analysis...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28291240/testosterone-levels-in-pre-menopausal-women-are-associated-with-nonalcoholic-fatty-liver-disease-in-midlife
#15
Monika Sarkar, Melissa Wellons, Marcelle I Cedars, Lisa VanWagner, Erica P Gunderson, Veeral Ajmera, Laura Torchen, David Siscovick, J Jeffrey Carr, James G Terry, Mary Rinella, Cora E Lewis, Norah Terrault
OBJECTIVES: Young women with hyperandrogenism have high risk of metabolic co-morbidities, including increased risk of nonalcoholic fatty liver disease (NAFLD). Whether testosterone (the predominant androgen) is associated with NAFLD independent of metabolic co-factors is unclear. Additionally, whether testosterone confers increased risk of NAFLD in women without hyperandrogenism is unknown. METHODS: Among women in the prospective population-based multicenter Coronary Artery Risk Development in Young Adults (CARDIA) study, we assessed whether free testosterone levels measured at Year 2 (1987-1988) were associated with prevalent NAFLD at Year 25 (2010-2011) (n=1052)...
March 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28285119/fitness-in-young-adulthood-and-long-term-cardiac-structure-and-function-the-cardia-study
#16
Ambarish Pandey, Norrina B Allen, Colby Ayers, Jared P Reis, Henrique T Moreira, Stephen Sidney, Jamal S Rana, David R Jacobs, Lisa S Chow, James A de Lemos, Mercedes Carnethon, Jarett D Berry
OBJECTIVES: This study sought to evaluate the association between early-life cardiorespiratory fitness (CRF) and measures of left ventricular (LV) structure and function in midlife. BACKGROUND: Low CRF in midlife is associated with a higher risk of heart failure. However, the unique contributions of early-life CRF toward measures of LV structure and function in middle age are not known. METHODS: CARDIA (Coronary Artery Risk Development in Young Adults) study participants with a baseline maximal treadmill test and an echocardiogram at year 25 were included...
March 5, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28276825/perioperative-chemotherapy-for-resectable-gastric-cancer-what-is-the-evidence
#17
Erling A Bringeland, Hans H Wasmuth, Jon E Grønbech
The UK MAGIC trial published in 2006 was the first RCT to identify improved long-term survival rates using preoperative chemotherapy for resectable gastric or gastroesophageal cancer. Overnight, the treatment regimen impacted European guidelines. However, the majority of patients underwent limited lymph node dissection, and analyses of the rates of curative resection, downsizing and downstaging were not by intention to treat, rightfully raising concerns about their validity. For the subset of true gastric cancers, meta-analyses may even question the claims of improved long-term survival rates by present-day regimens...
February 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28260958/sleep-apnea-risk-and-subclinical-atherosclerosis-in-early-middle-aged-retired-national-football-league-players
#18
Faith S Luyster, Reginald E Dunn, Diane S Lauderdale, Mercedes R Carnethon, Andrew M Tucker, Robert A Vogel, Andrew E Lincoln, Kristen L Knutson, Elliot J Pellman, Patrick J Strollo
PURPOSE: Limited data from former National Football League (NFL) players suggest that obstructive sleep apnea (OSA) may be highly prevalent after retirement. It remains unclear whether the high prevalence of OSA in retired players is comparable to nonathletes. This retrospective analysis compared sleep apnea (SA) risk in retired NFL players to a community cohort (CARDIA Sleep study), and examined associations between SA risk and cardiovascular risk factors, including subclinical atherosclerosis...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28253317/development-of-the-diabetes-typology-model-for-discerning-type-2-diabetes-mellitus-with-national-survey-data
#19
Anna Bellatorre, Sharon H Jackson, Kelvin Choi
OBJECTIVE: To classify individuals with diabetes mellitus (DM) into DM subtypes using population-based studies. DESIGN: Population-based survey. SETTING: Individuals participated in 2003-2004, 2005-2006, or 2009-2010 the National Health and Nutrition Examination Survey (NHANES), and 2010 Coronary Artery Risk Development in Young Adults (CARDIA) survey (research materials obtained from the National Heart, Lung, and Blood Institute Biologic Specimen and Data Repository Information Coordinating Center)...
2017: PloS One
https://www.readbyqxmd.com/read/28248886/endoscopic-submucosal-dissection-for-gastric-adenomyoma-a-rare-entity-of-15-cases-among-571-patients-with-gastric-submucosal-eminence-lesions
#20
Sinan Wang, Hailong Cao, Yujie Zhang, Mengque Xu, Xue Chen, Meiyu Piao, Bangmao Wang
Gastric adenomyoma (GA) is a kind of rare gastric submucosal eminence lesions. As the malignant transformation cannot be ruled out, surgery and laparoscopic resection are usually considered. The aim of this study is to evaluate the therapeutic effect and safety of endoscopic submucosal dissection (ESD) for GA.All of the patients with gastric submucosal eminence lesions who underwent ESD from June 2008 to June 2015 in General Hospital, Tianjin Medical University, China, were identified, and patients with GA, which was confirmed by pathological evaluation, were enrolled for further analysis...
March 2017: Medicine (Baltimore)
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