Read by QxMD icon Read


Samir Rabadiya, Shradhha Bhadada, Ashvin Dudhrejiya, Devendra Vaishnav, Bhoomika Patel
Estrogen is known to exhibit cardioprotective and antihyperlipidemic action. Valproic acid has been shown to upregulate estrogen receptors (ERs) in breast and prostate cancer tissues. No pharmacological evaluations for magnesium valproate (MgV) so far have been done for diabetic cadio-lipidemic complications. Based on the above context, current study was undertaken to evaluate the therapeutic effectiveness of MgV in cardiac complications associated with type-1 diabetes mellitus in rats wherein diabetes was induced by single tail vein injection of streptozotocin (STZ, 45mg/kg, IV) in female Sprague Dawley rats and treatment of MgV (210mg/kg, PO) was given for eight weeks to diabetic animals, after which, various biochemical and cardiac biomarkers, hypertrophic, hemodynamic and histological parameters along with immunohistochemistry of ERs in the left ventricle (LV) were estimated...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Priyanga Ranasinghe, Wasundara S Wathurapatha, Priyadarshani Galappatthy, Prasad Katulanda, Ranil Jayawardena, Godwin R Constantine
BACKGROUND: This study evaluated the effects of zinc supplementation on glycemic control, other cardiometabolic and anthropometric parameters, and disease progression in prediabetes. METHODS: A randomized double-blind placebo-controlled Phase 2 clinical trial was conducted over a 12-month period in 200 subjects (43% male; mean [± SD] age 51.8 ± 7.3 years), randomly assigned (1:  1) to the treatment or control group. The treatment group received zinc (20 mg daily)...
May 2018: Journal of Diabetes
Xiaoping Kang, Hong Jiang, Chunbo Wu, Xianzeng Liu, Jun Qiang, Fang Liu, Yang Guo, Danqing Xiao, Jingyi Liu, Jing Yu, Xuguang Gao, Youzhong An, Jihong Zhu, Fengxue Zhu
OBJECTIVE: To evaluate the application value of continuous video-electroencephalographic (cVEEG) monitoring in patients with consciousness disorders in intensive care unit (ICU). METHODS: Retrospective analyses were conducted for applying cVEEG in the clinical diagnosis and outcome evaluation of 54 patients with consciousness disorders in intensive care unit (ICU) at our hospital from January 2008 to April 2014. RESULTS: The most common cause was cerebrovascular disease (46...
June 2, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
E Bouissou-Cadio, M T Martin, N O Fortunel
No abstract text is available yet for this article.
June 2014: Annales de Dermatologie et de Vénéréologie
Disorders due to spinal cord compression or ischemic spinal cord lesions represent the most relevant non-traumatic spinal cord injuries causing acute para- and tetraplegia. In acute spinal cord compression early diagnosis is most reasonable to indicate early operative intervention with decompression to prevent progressive neurological deficits. In patients suffering from malignant disorders the indication for operation is directed to maintain quality of life in an appropriate level (pain treatment, mobility by wheelchair)...
November 1, 2000: Therapeutische Umschau. Revue Thérapeutique
Loubna Chadli, Emmanuelle Cadio, Pierre Vaigot, Michèle T Martin, Nicolas O Fortunel
The development of methods and tools suitable for functional analysis of keratinocytes placed in an in vitro context is of great importance for characterizing properties associated with their normal state, for detecting abnormalities related to pathological states, or for studying the effects of extrinsic factors. In the present chapter, we describe the use of the intracellular fluorescent dye carboxyfluorescein succinimidyl ester (CFSE) to monitor cell division in mass cultures of normal human keratinocytes...
2013: Methods in Molecular Biology
Nicolas O Fortunel, Loubna Chadli, Emilie Bourreau, Emmanuelle Cadio, Pierre Vaigot, Mélanie Marie, Nathalie Deshayes, Michelle Rathman-Josserand, Jacques Leclaire, Michèle T Martin
The regenerative capacity of human interfollicular epidermis is closely linked to the potential of immature keratinocytes present within its basal layer. The availability of selection methods and culture systems allowing precise assessment of basal keratinocyte characteristics is critical for increasing our knowledge of this cellular compartment. This report presents a multi-parametric comparative study of basal keratinocytes selected according to two different principles: 1) high adhesion capacity on a type-I collagen-coated substrate [Adh⁺⁺⁺], 2) high cell-surface expression of α6-integrin [Itg-α6 (high)]...
May 2011: European Journal of Dermatology: EJD
Nicolas O Fortunel, Emmanuelle Cadio, Pierre Vaigot, Loubna Chadli, Sandra Moratille, Stéphan Bouet, Paul-Henri Roméo, Michèle T Martin
The basal layer of human epidermis contains both stem cells and keratinocyte progenitors. Because of this cellular heterogeneity, the development of methods suitable for investigations at a clonal level is dramatically needed. Here, we describe a new method that allows multi-parallel clonal cultures of basal keratinocytes. Immediately after extraction from tissue samples, cells are sorted by flow cytometry based on their high integrin-alpha 6 expression and plated individually in microculture wells. This automated cell deposition process enables large-scale characterization of primary clonogenic capacities...
April 2010: Experimental Dermatology
Nicolas O Fortunel, Pierre Vaigot, Emmanuelle Cadio, Michèle T Martin
The basal layer of human interfollicular epidermis is thought to contain a minor compartment of quiescent or slowly cycling epithelial stem cells. These primitive keratinocytes give rise to the progenitors, which are the proliferating keratinocytes and which can be defined as early to late progenitors, according to their differentiation status. Because of the intrinsic heterogeneity of the basal layer, the development of new methods suitable for functional analysis of basal keratinocytes directly isolated from skin samples is greatly needed...
2010: Methods in Molecular Biology
B Khoshnood, C De Vigan, B Blondel, V Vodovar, E Cadio, F Goffinet
OBJECTIVE: To assess long-term trends in disparities for prenatal diagnosis of Down syndrome in relation to policy changes. DESIGN: Population-based observational study. SETTING: Paris. POPULATION: Residents of Paris who gave birth or had a termination of pregnancy in Paris during 1983-2003 (approximately 23,000 births per year). METHODS: Using population-based data from the Paris Registry of Congenital Malformations on 1934 cases of Down syndrome, we assessed differences in prenatal diagnosis proportions by maternal profession and geographical origin for the years 1983-2003...
August 2008: BJOG: An International Journal of Obstetrics and Gynaecology
C de Vigan, B Khoshnood, E Cadio, V Vodovar, F Goffinet
OBJECTIVES: To assess recent trends in the prevalence of Down syndrome and the proportion of cases with a prenatal diagnosis in the Parisian population. PATIENTS AND METHODS: Four hundred and ninety-nine cases of Down syndrome were registered by the Paris Registry of Congenital Anomalies during the period 2001-2005. All cases with prenatal diagnosis were confirmed by cytogenetic examination. We analyzed trends in the total and live birth prevalence, the proportion of cases with a prenatal diagnosis and those with a pregnancy termination, as well as gestational age at diagnosis and termination...
February 2008: Gynécologie, Obstétrique & Fertilité
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"