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https://www.readbyqxmd.com/read/29040685/a-pooled-analysis-of-dietary-sugar-carbohydrate-intake-and-esophageal-and-gastric-cardia-adenocarcinoma-incidence-and-survival-in-the-usa
#1
Nan Li, Jessica L Petrick, Susan E Steck, Patrick T Bradshaw, Kathleen M McClain, Nicole M Niehoff, Lawrence S Engel, Nicholas J Shaheen, Harvey A Risch, Thomas L Vaughan, Anna H Wu, Marilie D Gammon
Background: During the past 40 years, esophageal/gastric cardia adenocarcinoma (EA/GCA) incidence increased in Westernized countries, but survival remained low. A parallel increase in sugar intake, which may facilitate carcinogenesis by promoting hyperglycaemia, led us to examine sugar/carbohydrate intake in association with EA/GCA incidence and survival. Methods: We pooled 500 EA cases, 529 GCA cases and 2027 controls from two US population-based case-control studies with cases followed for vital status...
September 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040424/body-contouring-surgery-and-the-maintenance-of-weight-loss-following-roux-en-y-gastric-bypass-a-retrospective-study
#2
Oliver J Smith, Nadine Hachach-Haram, Max Greenfield, Nicki Bystrzonowski, Andrea Pucci, Rachel L Batterham, Majid Hashemi, Afshin Mosahebi
Background: Bariatric surgery leads to significant weight loss with reduced morbidity and mortality. However, excess skin as a consequence of weight loss represents a major problem, impacting upon patient's functionality with potential negative effects on weight loss. Objectives: We evaluated the effect of body-contouring surgery on weight-loss maintenance following bariatric surgery. Methods: We undertook a retrospective analysis of patients undergoing Roux-en-Y gastric bypass (RYGB) +/- body-contouring surgery (BC)...
October 4, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29034986/access-to-a-youth-specific-service-for-young-adults-with-type-1-diabetes-mellitus-is-associated-with-decreased-hospital-length-of-stay-for-diabetic-ketoacidosis
#3
Kharis Burns, Kaye Farrell, Rickie Myszka, Kris Park, Deborah Jane Holmes-Walker
BACKGROUND: Management of Type 1 diabetes mellitus (T1DM) in youth with diabetes is complex and glycaemic control often deteriorates during this challenging period. We hypothesise that attendance at a youth-specific diabetes clinic reduces hospital admission rates and length of stay for diabetic ketoacidosis (DKA). AIMS: This study aimed to assess the impact of a youth specific diabetes service for youth with diabetes (YWD) on DKA admissions in two adjacent local health districts (LHDs)...
October 16, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29033057/clinical-inertia-versus-overtreatment-in-glycaemic-management
#4
Kamlesh Khunti, Melanie J Davies
No abstract text is available yet for this article.
October 9, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29030337/diabetic-patients-with-poor-glycaemic-control-have-higher-risk-of-latent-tb-study-shows
#5
Sophie Cousins
No abstract text is available yet for this article.
October 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29029859/intensive-insulin-therapy-insulin-sensitisers-and-insulin-secretagogues-for-burns-a-systematic-review-of-effectiveness-and-safety
#6
REVIEW
Jared M Campbell, Natalia Adanichkin, Rochelle Kurmis, Zachary Munn
This systematic review investigated the effectiveness and safety of intensive insulin therapy (IIT), insulin secretagogues and sensitisers in burn patients. PubMed, Embase, clinicaltrials.gov and Cochrane central were searched from 1990 to 2016. Title/abstract screening, full-text review, critical appraisal and data extraction were carried out by two independent reviewers. Inclusion criteria were hospitalised burn patients, IIT, insulin sensitisers or secretagogues and the outcomes mortality, length of stay, resting energy expenditure, blood glucose, catabolism, or complications...
October 10, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29026922/erratum-to-innovative-technology-shows-impact-of-glycaemic-control-on-peripheral-retinal-vessels-in-adolescents-with-type-1-diabetes
#7
Valli Velayutham, Paul Z Benitez-Aguirre, Maria E Craig, Gerald Liew, Tien Y Wong, Alicia J Jenkins, Kim C Donaghue
No abstract text is available yet for this article.
October 1, 2017: Diabetologia
https://www.readbyqxmd.com/read/29026101/heterozygous-rfx6-protein-truncating-variants-are-associated-with-mody-with-reduced-penetrance
#8
Kashyap A Patel, Jarno Kettunen, Markku Laakso, Alena Stančáková, Thomas W Laver, Kevin Colclough, Matthew B Johnson, Marc Abramowicz, Leif Groop, Päivi J Miettinen, Maggie H Shepherd, Sarah E Flanagan, Sian Ellard, Nobuya Inagaki, Andrew T Hattersley, Tiinamaija Tuomi, Miriam Cnop, Michael N Weedon
Finding new causes of monogenic diabetes helps understand glycaemic regulation in humans. To find novel genetic causes of maturity-onset diabetes of the young (MODY), we sequenced MODY cases with unknown aetiology and compared variant frequencies to large public databases. From 36 European patients, we identify two probands with novel RFX6 heterozygous nonsense variants. RFX6 protein truncating variants are enriched in the MODY discovery cohort compared to the European control population within ExAC (odds ratio = 131, P = 1 × 10(-4))...
October 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29026049/diabetes-in-older-people-position-statement-of-the-hong-kong-geriatrics-society-and-the-hong-kong-society-of-endocrinology-metabolism-and-reproduction
#9
C W Wong, J Sw Lee, K F Tam, H F Hung, W Y So, C K Shum, C Y Lam, J N Cheng, S P Man, T W Auyeung
Following a survey on the clinical practice of geriatricians in the management of older people with diabetes and a study of hypoglycaemia in diabetic patients, a round-table discussion with geriatricians and endocrinologists was held in January 2015. Consensus was reached for six domains specifically related to older diabetic people: (1) the considerations when setting an individualised diabetic management; (2) inclusion of geriatric syndrome screening in assessment; (3) glycaemic and blood pressure targets; (4) pharmacotherapy; (5) restrictive diabetic diet; and (6) management goals for nursing home residents...
October 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29025920/heartbeat-glycaemic-control-and-excess-risk-of-major-coronary-events-in-type-1-diabetes
#10
Kazem Rahimi, Catherine M Otto
No abstract text is available yet for this article.
November 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29025432/psychometric-properties-of-the-diabetes-self-management-questionnaire-dsmq-in-urdu
#11
Allah Bukhsh, Shaun Wen Huey Lee, Priyia Pusparajah, Andreas Schmitt, Tahir Mehmood Khan
BACKGROUND: Numerous study tools on diabetes self-care have been introduced; however, most existing tools do not show expectable and meaningful correlations with patients' glycaemic control. The Diabetes Self-Management Questionnaire (DSMQ) was designed to appraise self-care activities which can predict glycaemic control outcomes. However, this tool has not been validated in Pakistan. Therefore, the aim of this study was to translate and examine the psychometric properties of the Urdu version of DSMQ among type 2 diabetes patients...
October 12, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29024408/effects-of-glucagon-like-peptide-1-glp-1-receptor-agonists-on-cardiovascular-risk-factors-a-narrative-review-of-head-to-head-comparisons
#12
REVIEW
Niels B Dalsgaard, Tina Vilsbøll, Filip K Knop
Cardiovascular (CV) disease is the leading cause of death and morbidity in patients with type 2 diabetes. Five CV risk factors (blood pressure, resting heart rate [HR], body weight, cholesterol levels and blood glucose) are monitored routinely as safety and efficacy endpoints in randomised clinical trials for diabetes therapies. To determine if different glucagon-like peptide-1 receptor agonists (GLP-1RAs) had varying effects on these CV risk factors, we reviewed 16 head-to-head trials directly comparing GLP-1RAs that included at least one of the five factors...
October 12, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29023081/frailty-predicts-adverse-outcomes-in-older-people-with-diabetes
#13
Joanna Ulley, Ahmed H Abdelhafiz
The greatest proportional increase in the number of people with diabetes by age group is predicted to occur in those aged 60 to 79. In older people living with diabetes, geriatric syndromes, which indicate frailty, are emerging as a third category of complications in addition to the traditional microvascular and macrovascular sequelae. Frailty is defined by the presence of three or more phenotypes (weight loss, weakness, decreased physical activity, exhaustion and slow gait speed). The presence of one or two phenotypes describes a pre-frail state, and the absence of phenotypes describes a non-frail person...
January 2017: Practitioner
https://www.readbyqxmd.com/read/29022162/the-effect-of-religious-belief-and-forgiveness-on-coping-with-diabetes
#14
Ece Yazla, Mehmet Emrah Karadere, Ferit Kerim Küçükler, Çağatay Karşıdağ, Leman İnanç, Elif Kankoç, Melda Dönertaş, Emre Demir
We aimed to investigate the relationship of religious beliefs and forgiveness in diabetic patients with various sociodemographic characteristics, emotional problems and glycaemic control. The study comprises 100 patients diagnosed with type 2 DM. We used a data collection form, the Scale of Forgiveness and Religiosity (SFR), Problem Areas in Diabetes Scale (PAID), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI) and the Audit of Diabetes-Dependent Quality of Life (ADDQoL). We also recorded blood glucose and HbA1c test results...
October 11, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/29022100/sea-buckthorn-decreases-and-delays-insulin-response-and-improves-glycaemic-profile-following-a-sucrose-containing-berry-meal-a-randomised-controlled-crossover-study-of-danish-sea-buckthorn-and-strawberries-in-overweight-and-obese-male-subjects
#15
Maria Wichmann Mortensen, Camilla Spagner, Cătălina Cuparencu, Arne Astrup, Anne Raben, Lars Ove Dragsted
PURPOSE: Berries and mixed berry products exert acute effects on postprandial glycaemia and insulinemia, but very few berries have been studied, and primarily in normal weight subjects. Sea buckthorn and strawberry are compositionally widely different berries and may likely produce different responses. The effects of strawberry and sea buckthorn on postprandial glycaemia and insulinemia were examined in overweight or obese male subjects. Subjective appetite sensations and ad libitum intake were also examined...
October 11, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29021909/managing-diabetes-at-high-altitude-personal-experience-with-support-from-a-multidisciplinary-physical-activity-and-diabetes-clinic
#16
Gary Malcolm, Sian Rilstone, Sivasujan Sivasubramaniyam, Carol Jairam, Stephen Chew, Nick Oliver, Neil E Hill
OBJECTIVE: Physical activity is important for well-being but can be challenging for people with diabetes. Data informing support of specialist activities such as climbing and high-altitude trekking are limited. A 42-year-old man with type 1 diabetes (duration 30 years) attended a Multidisciplinary Physical Activity and Diabetes Clinic planning to climb Mont Blanc during the summer and trek to Everest Base Camp in the autumn. His aims were to complete these adventures without his diabetes impacting on their success...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29018885/size-and-shape-of-the-associations-of-glucose-hba1c-insulin-and-homa-ir-with-incident-type-2-diabetes-the-hoorn-study
#17
Carolien Ruijgrok, Jacqueline M Dekker, Joline W Beulens, Ingeborg A Brouwer, Veerle M H Coupé, Martijn W Heymans, Femke P C Sijtsma, David J Mela, Peter L Zock, Margreet R Olthof, Marjan Alssema
AIMS/HYPOTHESIS: Glycaemic markers and fasting insulin are frequently measured outcomes of intervention studies. To extrapolate accurately the impact of interventions on the risk of diabetes incidence, we investigated the size and shape of the associations of fasting plasma glucose (FPG), 2 h post-load glucose (2hPG), HbA1c, fasting insulin and HOMA-IR with incident type 2 diabetes mellitus. METHODS: The study population included 1349 participants aged 50-75 years without diabetes at baseline (1989) from a population-based cohort in Hoorn, the Netherlands...
October 10, 2017: Diabetologia
https://www.readbyqxmd.com/read/29018826/high-prevalence-of-autoimmune-diabetes-and-poor-glycaemic-control-among-adults-in-madagascar-a-brief-report-from-a-humanitarian-health-campaign-in-ambanja
#18
Ernesto Maddaloni, Giovanlorenzo Pastore, Marco Giuseppe Del Buono, Aldostefano Porcari, Mario Fittipaldi, Francesco Garilli, Claudio Tiberti, Silvia Angeletti, Paolo Pozzilli, Giovanni Mottini, Nicola Napoli
Madagascar is a geographically isolated country considered a biodiversity hotspot with unique genomics. Both the low-income and the geographical isolation represent risk factors for the development of diabetes. During a humanitarian health campaign conducted in Ambanja, a rural city in the northern part of Madagascar, we identified 42 adult subjects with diabetes and compared their features to 24 randomly enrolled healthy controls. 42.9% (n = 18) of diabetic subjects showed HbA1c values ≥ 9.0%. Unexpectedly, waist circumference and BMI were similar in people with diabetes and controls...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29016751/cardiac-effects-of-sglt2-inhibitors-the-sodium-hypothesis
#19
Edoardo Bertero, Leticia Prates Roma, Pietro Ameri, Christoph Maack
The effects of intense glycaemic control on macrovascular complications in patients with type 2 diabetes are incompletely resolved, and many glucose-lowering medications negatively affect cardiovascular outcomes. Recently, the EMPA-REG OUTCOME trial revealed that empagliflozin, an inhibitor of the sodium-glucose cotransporter 2 (SGLT2), substantially reduced the risk of hospitalization for heart failure, death from cardiovascular causes, and all-cause mortality in patients with type 2 diabetes mellitus at high cardiovascular risk...
August 4, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28993227/adverse-glycaemic-effects-of-cancer-therapy-indications-for-a-rational-approach-to-cancer-patients-with-diabetes
#20
REVIEW
Marco Gallo, Giovanna Muscogiuri, Francesco Felicetti, Antongiulio Faggiano, Francesco Trimarchi, Emanuela Arvat, Riccardo Vigneri, Annamaria Colao
Diabetes and cancer are common, chronic, and potentially fatal diseases that frequently co-exist. Observational studies have reported an increased risk of cancer in patients with diabetes. Furthermore, many patients with cancer already have diabetes, or develop hyperglycemia as a consequence of the tumor or of cancer therapies, and coexisting diabetes confers a greater risk of mortality for many malignancies. Managing oncologic patients with diabetes is often complicated, since the co-existence of diabetes and cancer poses several complex clinical questions: what level of glycemic control to achieve, which therapy to use, how to deal with glucocorticoid therapies and artificial nutrition, how diabetes complications can affect cancer management, which drug-drug interactions should be taken into account, or even how to manage diabetes at the end of life...
October 6, 2017: Metabolism: Clinical and Experimental
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