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https://www.readbyqxmd.com/read/29675260/one-too-many-diabetes-the-combination-of-hyperglycaemic-hyperosmolar-state-and-central-diabetes-insipidus
#1
Snezana Burmazovic, Christoph Henzen, Lukas Brander, Luca Cioccari
The combination of hyperosmolar hyperglycaemic state and central diabetes insipidus is unusual and poses unique diagnostic and therapeutic challenges for clinicians. In a patient with diabetes mellitus presenting with polyuria and polydipsia, poor glycaemic control is usually the first aetiology that is considered, and achieving glycaemic control remains the first course of action. However, severe hypernatraemia, hyperglycaemia and discordance between urine-specific gravity and urine osmolality suggest concurrent symptomatic diabetes insipidus...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29675256/a-case-with-relapsed-transient-neonatal-diabetes-mellitus-treated-with-sulfonylurea-ending-chronic-insulin-requirement
#2
Akihiko Ando, Shoichiro Nagasaka, Shun Ishibashi
We report a case of a woman with diabetes mellitus caused by a genetic defect in ABCC8 -coding sulfonylurea receptor 1 (SUR1), a subunit of the ATP-sensitive potassium (KATP ) channel protein. She was diagnosed with diabetes at 7 days after birth. After intravenous insulin drip for 1 month, her hyperglycaemia remitted. At the age of 13 years, her diabetes relapsed, and after that she had been treated by intensive insulin therapy for 25 years with relatively poor glycaemic control. She was switched to oral sulfonylurea therapy and attained euglycaemia...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29674706/discordance-in-glycemic-categories-and-regression-to-normality-at-baseline-in-10-000-people-in-a-type-2-diabetes-prevention-trial
#3
Mike Sampson, Tim Elwell-Sutton, Max O Bachmann, Allan Clark, Ketan K Dhatariya, Clare Ferns, Amanda Howe, W Garry John, Gerry Rayman, Leyla Swafe, Jeremy Turner, Melanie Pascale
The world diabetes population quadrupled between 1980 and 2014 to 422 million and the enormous impact of Type 2 diabetes is recognised by the recent creation of national Type 2 diabetes prevention programmes. There is uncertainty about how to correctly risk stratify people for entry into prevention programmes, how combinations of multiple 'at high risk' glycemic categories predict outcome, and how the large recently defined 'at risk' population based on an elevated glycosylated haemoglobin (HbA1c) should be managed...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674136/glycaemic-control-and-glycaemic-variability-in-older-people-with-diabetes
#4
Hermes J Florez
No abstract text is available yet for this article.
April 16, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29674135/mean-hba-1c-hba-1c-variability-and-mortality-in-people-with-diabetes-aged-70-years-and-older-a-retrospective-cohort-study
#5
Angus Forbes, Trevor Murrells, Henrietta Mulnier, Alan J Sinclair
BACKGROUND: Glycaemic targets for older people have been revised in recent years because of concern that more stringent targets are associated with increased mortality. We aimed to investigate the association between glycaemic control (mean HbA1c ) and variability (variability of HbA1c over time) and mortality in older people with diabetes. METHODS: We did a 5-year retrospective cohort study using The Health Improvement Network database, which includes data from 587 UK primary care practices...
April 16, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29673826/lifestyle-interventions-for-improving-health-and-health-behaviours-in-women-with-type-2-diabetes-a-systematic-review-of-the-literature-2011-2017
#6
REVIEW
Charrlotte Seib, Joy Parkinson, Nicole McDonald, Haruka Fujihira, Stephanie Zietek, Debra Anderson
The development and maintenance of healthy lifestyle behaviours are among the most promising strategies for reducing complications and premature death among women living with type 2 diabetes mellitus (T2DM). However, despite the potential benefits of these interventions, they have had varying success and the sustained uptake of the recommended lifestyle modifications is limited. This paper reviews research on the impact of lifestyle interventions aimed at improving health and health behaviours in women with T2DM...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29672991/glycaemic-optimization-for-patients-with-cardiac-disease-a-before-and-after-study
#7
Tripti Joshi, Sarah-Jane Pullen, Alison Gebuehr, Christopher Oldmeadow, John Richard Attia, Shamasunder Halady Acharya
AIM: To investigate if glycaemic profiles and outcomes of patients with diabetes admitted for cardiothoracic surgery or acute coronary syndrome improved after implementation of a structured glycaemia management guideline. METHODS: This is a retrospective before-and-after comparative analysis of outcomes for all consecutive cardiothoracic and acute coronary syndrome patients with diabetes (N = 375), who were admitted at our tertiary-care university-affiliated hospital during the preguideline period (July-December, 2013) and the postguideline period (July-December, 2014)...
April 19, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29669179/beta-cell-stress-in-a-4-year-follow-up-of-patients-with-type-2-diabetes-a-longitudinal-analysis-of-the-betadecline-study
#8
Giuseppina T Russo, Carlo B Giorda, Stefania Cercone, Salvatore De Cosmo, Antonio Nicolucci, Domenico Cucinotta
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with a progressive deterioration in beta cell function and loss of glycaemic control. Clinical predictors of beta cell failure are needed to guide appropriate therapy. METHODS: A prospective evaluation of a large set of potential predictors of beta cell stress, measured as change in the proinsulin/insulin (PI/I) ratio, was conducted in a cohort of 235 outpatients with T2DM on stable treatment with oral hypoglycaemic agents or diet followed-up for ~4 years (median value 3...
April 18, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29666090/rare-case-of-chorea-hyperglycaemia-basal-ganglia-c-h-bg-syndrome
#9
Sajjad Ahmad, Priya Mohan Babu, Lavanya Shenbagaraj, Lindsay George
An 83-year-old woman presented with acute-onset haemichorea and haemiballism particularly affecting the left side of the body. She was known to have type 2 diabetes, which was poorly controlled with sitagliptin. She was hyperglycaemic but not ketotic or acidotic. After she was started on insulin and good glycaemic control was achieved, her abnormal movements dramatically improved. MRI of the brain showed a T1-weighted hyperintense lesion on the right basal ganglia, which is typical of chorea-hyperglycaemia-basal ganglia syndrome...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29661995/greater-glycaemic-response-to-an-oral-glucose-load-in-healthy-lean-active-and-young-chinese-adults-compared-to-matched-caucasians
#10
Trevor Simper, Caroline Dalton, David Broom, Waleed Ibrahim, Lingjin Li, Charles Bankole, Sisi Chen
There are ethnic differences recorded in glycaemic response and rates of type 2 diabetes mellitus (DM) between Chinese and Caucasian populations. Whether these differences are evident in matched healthy, lean, active, young adults is unclear. This study compares the postprandial glycaemic response of a group of Chinese participants ( n = 49) with a group of similar Caucasians, ( n = 48) aged 23.8 (±4.35 years), body mass index (BMI) 22.7 (±2.6) kg/m², healthy (free from non-communicable disease), and lean (body fat % 23...
April 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29656910/glycemic-control-is-an-important-modifiable-risk-factor-for-uveitis-in-patients-with-diabetes-a-retrospective-cohort-study-establishing-clinical-risk-and-ophthalmic-disease-burden
#11
Abdus Samad Ansari, Simon de Lusignan, William Hinton, Neil Munro, Simon Taylor, Andrew McGovern
AIM: To characterize the risk uveitis, scleritis or episcleritis in relation to diabetes, glycaemic control, and co-existence of retinopathy. METHODS: Using the Royal College of General Practitioners Research and Surveillance Centre database, we established the prevalence of acute uveitis and scleritis or episcleritis over a six-year period among populations without(n = 889,856) and with diabetes(n = 48,584). We evaluated the impact of glycaemic control on disease risk...
March 23, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29656554/a-single-day-of-bed-rest-irrespective-of-energy-balance-does-not-affect-skeletal-muscle-gene-expression-or-insulin-sensitivity
#12
Marlou L Dirks, Francis B Stephens, Sarah R Jackman, Jesús Galera Gordo, David Machin, Richard M Pulsford, Luc Jc van Loon, Benjamin T Wall
NEW FINDINGS: What is the central question of this study? What are the initial metabolic and molecular events that underpin bed rest-induced skeletal muscle deconditioning, and what is the contribution of energy balance? What is the main finding and its importance? A single day of bed rest, irrespective of energy balance, did not lead to overt changes in skeletal muscle gene expression or insulin sensitivity. More than one day of physical inactivity is required to observe the insulin resistance and robust skeletal muscle transcriptional responses associated with bed rest and consequent alterations in energy balance...
April 15, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29653463/estimation-of-glycaemic-control-in-the-past-month-using-ratio-of-glycated-albumin-to-hba-1c
#13
I Musha, M Mochizuki, T Kikuchi, J Akatsuka, A Ohtake, K Kobayashi, N Kikuchi, T Kawamura, I Yokota, T Urakami, S Sugihara, S Amemiya
AIMS: To evaluate comprehensively the use of the glycated albumin to HbA1c ratio for estimation of glycaemic control in the previous month. METHODS: A total of 306 children with Type 1 diabetes mellitus underwent ≥10 simultaneous measurements of glycated albumin and HbA1c . Correlation and concordance rates were examined between HbA1c measurements taken 1 month apart (ΔHbA1c ) and glycated albumin/HbA1c ratio fluctuations were calculated as Z-scores from the cohort value at enrolment (method A) or the percent difference from the individual mean over time (method B)...
April 13, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29652101/switching-from-sitagliptin-to-liraglutide-to-manage-patients-with-type-2-diabetes-in-the-uk-a-long-term-cost-effectiveness-analysis
#14
Anthony H Barnett, Simon Arnoldini, Barnaby Hunt, Gowri Subramanian, Christina Stentoft Hoxer
AIMS: The recent LIRA-SWITCH trial showed that switching from sitagliptin 100 mg to liraglutide 1.8 mg led to statistically significant and clinically relevant improvements in glycated haemoglobin (HbA1c ) and body mass index (BMI). Based on these findings, the aim of the present study was to assess the long-term cost-effectiveness of switching from sitagliptin to liraglutide in patients with type 2 diabetes in the UK. MATERIALS AND METHODS: The IQVIA CORE Diabetes Model Version 8...
April 13, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29649949/postprandial-effects-of-breakfast-glycaemic-index-on-cognitive-performance-among-young-healthy-adults-a-crossover-clinical-trial
#15
Natalia Sanchez-Aguadero, Jose I Recio-Rodriguez, Maria C Patino-Alonso, Sara Mora-Simon, Rosario Alonso-Dominguez, Benigna Sanchez-Salgado, Manuel A Gomez-Marcos, Luis Garcia-Ortiz
OBJECTIVE: To evaluate the postprandial effects of high and low glycaemic index (GI) breakfasts on cognitive performance in young, healthy adults. METHODS: A crossover clinical trial including 40 young, healthy adults (aged 20-40 years, 50% females) recruited from primary healthcare centres in Salamanca, Spain. Verbal memory, phonological fluency, attention, and executive functions were examined 0, 60, and 120 minutes after consuming a low GI (LGI), high GI (HGI), or water breakfast...
April 12, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29649539/switching-to-insulin-glargine-300-u-ml-is-duration-of-prior-basal-insulin-therapy-important
#16
Riccardo C Bonadonna, Eric Renard, Alice Cheng, Andreas Fritsche, Anna Cali, Lydie Melas-Melt, Guillermo E Umpierrez
AIMS: To assess the impact of duration of prior basal insulin therapy on study outcomes in people with type 2 diabetes mellitus receiving insulin glargine 300 U/mL (Gla-300) or insulin glargine 100 U/mL (Gla-100) for 6 months. METHODS: A post hoc patient-level meta-analysis of data from the EDITION 1 and 2 studies. Outcomes included: HbA1c , percentage of participants with ≥1 confirmed or severe hypoglycaemic event at night (00:00-05:59 h) or any time (24 h), and body weight change...
April 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29648664/how-does-the-association-of-general-and-central-adiposity-with-glycaemia-and-blood-pressure-differ-by-gender-and-area-of-residence-in-a-malawian-population-a-cross-sectional-study
#17
Kathleen Mudie, Debbie A Lawlor, Neil Pearce, Amelia Crampin, Laurie Tomlinson, Terence Tafatatha, Crispin Musicha, Dorothea Nitsch, Liam Smeeth, Moffat J Nyirenda
Background: In high-income settings, body mass index (BMI) and measures of central adiposity, such as waist-to-hip ratio (WHR) are associated with cardiometabolic risk, but evidence from low-income settings, particularly sub-Saharan Africa (SSA), is limited. We assessed whether there are differences between central and general adiposity in their associations with fasting glucose, diabetes, systolic and diastolic blood pressures and hypertension, and whether these associations differ with gender or rural/urban setting in Malawi...
April 10, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29648479/dietary-intervention-and-health-in-patients-with-systemic-lupus-erythematosus-a-systematic-review-of-the-evidence
#18
Marília Cristina Santos de Medeiros, Jussara Cristina Alves Medeiros, Humberto Jefferson de Medeiros, José Carlos Gomes de Carvalho Leitão, Maria Irany Knackfuss
OBJECTIVE: The aim of this study was to evaluate the scientific evidence of dietary intervention, either through diet or supplementation, and its effects on the health of patients with systemic lupus erythematosus. METHODS: Literature searches were conducted using Scopus, PubMed, BioMed Central and Science Direct databases. The terms used for the search were diet, nutritional support, nutrition therapy and systemic lupus erythematosus. RESULTS: Eleven studies with interventions related to supplementation of omega-3 fatty acids, vitamin D and turmeric, as well as changes in diet composition, such as low glycaemic index diet were identified...
April 12, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29644952/carbohydrate-dietary-glycaemic-index-and-glycaemic-load-and-colorectal-cancer-risk-a-case-control-study-in-china
#19
Jing Huang, Yu-Jing Fang, Ming Xu, Hong Luo, Nai-Qi Zhang, Wu-Qing Huang, Zhi-Zhong Pan, Yu-Ming Chen, Cai-Xia Zhang
A carbohydrate-rich diet results in hyperglycaemia and hyperinsulinaemia; it may further induce the carcinogenesis of colorectal cancer. However, epidemiological evidence among Chinese population is quite limited. The aim of this study was to investigate total carbohydrate, non-fibre carbohydrate, total fibre, starch, dietary glycaemic index (GI) and glycaemic load (GL) in relation to colorectal cancer risk in Chinese population. A case-control study was conducted from July 2010 to April 2017, recruiting 1944 eligible colorectal cancer cases and 2027 age (5-year interval) and sex frequency-matched controls...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29642898/enablers-and-barriers-for-women-with-gestational-diabetes-mellitus-to-achieve-optimal-glycaemic-control-a-qualitative-study-using-the-theoretical-domains-framework
#20
Ruth Martis, Julie Brown, Judith McAra-Couper, Caroline A Crowther
BACKGROUND: Glycaemic target recommendations vary widely between international professional organisations for women with gestational diabetes mellitus (GDM). Some studies have reported women's experiences of having GDM, but little is known how this relates to their glycaemic targets. The aim of this study was to identify enablers and barriers for women with GDM to achieve optimal glycaemic control. METHODS: Women with GDM were recruited from two large, geographically different, hospitals in New Zealand to participate in a semi-structured interview to explore their views and experiences focusing on enablers and barriers to achieving optimal glycaemic control...
April 11, 2018: BMC Pregnancy and Childbirth
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