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https://www.readbyqxmd.com/read/29931731/variations-in-access-to-and-reimbursement-for-continuous-glucose-monitoring-systems-for-people-living-with-type-1-diabetes-across-england
#1
R Perera, N Oliver, E Wilmot, C Marriott
Since the introduction of real-time continuous glucose monitoring (CGM) systems more than 15 years ago and, more recently, flash glucose monitoring (Flash-GM), clinical studies have observed reductions in HbA1c , independent of insulin delivery method, with decreasing time spent in hypoglycaemia [1] and reduction in glycaemic variability [2]. CGM can improve quality of life and reduce diabetes-related distress [3], including fear of hypoglycaemia [4,5]. Despite these benefits, CGM has yet to be fully implemented as part of the standard of care for people living with Type 1 diabetes in England, and there is considerable variation in how it is funded through local payer organizations...
June 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29930148/safe-and-effective-glycaemic-control-in-premature-infants-observational-clinical-results-from-the-computerised-star-gryphon-protocol
#2
Jennifer L Knopp Nee Dickson, Adrienne M Lynn, Geoffrey M Shaw, J Geoffrey Chase
OBJECTIVE: Previous studies examine clinical outcomes of insulin therapy in neonatal intensive care units (NICUs), without first developing safe and effective control protocols. This research quantifies the safety and performance of a computerised model-based control algorithmSTAR-GRYPHON (Stochastic TARgeted Glucose Regulation sYstem to Prevent Hyper- and hypO-glycaemia in Neonates). DESIGN: Retrospective observational study of glycaemic control in very/extremely low birthweight infants treated with insulin from Christchurch Women's Hospital NICU between January 2013 and June 2017...
June 21, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29927057/role-of-diet-and-food-intake-in-age-related-macular-degeneration-a-systematic-review
#3
REVIEW
Naoko A Chapman, Robert J Jacobs, Andrea J Braakhuis
A systematic literature review was conducted to evaluate the role of diet and food intake in age-related macular degeneration (AMD). Eighteen high-quality studies were identified. Adherence to a Mediterranean diet had decreased risk of AMD progression. An Oriental diet pattern had decreased association with AMD prevalence, whereas a Western diet pattern had increased association with AMD prevalence. High consumption of vegetables rich in carotenoids, and fatty fish containing omega-3 fatty acids was beneficial for those at risk of AMD...
June 21, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29925556/bilateral-chorea-ballismus-detection-and-management-of-a-rare-complication-of-non-ketotic-hyperglycaemia
#4
Venkata Sunil Bendi, Abhishek Matta, Diego Torres-Russotto, James Shou
Non-ketotic hyperglycaemia (NKH) is the most common metabolic cause of hemichorea-hemiballismus (HC-HB) and an often-reversible condition. A 68-year-old man presented to the emergency department with a severe hyperglycaemic episode and altered mental status. He was treated appropriately and discharged home after his blood glucose levels were normal with an improvement of mental status. Four weeks after the discharge, he returned with flailing movements of bilateral upper and lower limbs. MRI of the brain revealed hyperintensities of the bilateral putamen on T1-weighted imaging...
June 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29923427/renoprotective-effects-of-canagliflozin-a-sodium-glucose-cotransporter-2-inhibitor-in-type-2-diabetes-patients-with-chronic-kidney-disease-a-randomized-open-label-prospective-trial
#5
Hiroyuki Takashima, Yoshinori Yoshida, Chinami Nagura, Tetsuya Furukawa, Ritsukou Tei, Takashi Maruyama, Noriaki Maruyama, Masanori Abe
BACKGROUND: To evaluate the renoprotective effects of canagliflozin, we assessed the albuminuria-lowering effect in Japanese type 2 diabetes patients with chronic kidney disease (CKD). METHODS: In this prospective, open-label, parallel-group study, type 2 diabetes patients with CKD were randomized to receive either oral canagliflozin (100 mg/day) or usual care (control group) for 52 weeks. Endpoints included changes in urinary albumin-to-creatinine ratio (UACR), other urinary biomarkers, laboratory parameters, and adverse events...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29923361/efficacy-of-iglarlixi-a-fixed-ratio-combination-of-insulin-glargine-and-lixisenatide-in-patients-with-type-2-diabetes-stratified-as-high-and-low-risk-according-to-hedis-measures
#6
Danny H Sugimoto, Terry Dex, William Stager, Vanita R Aroda
The Healthcare Effectiveness Data and Information Set (HEDIS) measures assess glycaemic goal attainment in patients with type 2 diabetes, incorporating factors including age and health status. Healthier patients are assigned a glycated haemoglobin (HbA1c) goal of < 7% (classified as low-risk [LR]); individuals aged > 65 years or with comorbidities are assigned a goal of < 8% (high-risk [HR]). This post-hoc analysis assessed the safety and efficacy of iGlarLixi, a fixed-ratio combination of insulin glargine 100 U/mL (iGlar) and lixisenatide, in 1,898 patients from the phase 3 LixiLan-L and LixiLan-O clinical trials, retrospectively classified as LR (n = 1,181) or HR (n = 717)...
June 19, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29922352/a-comparison-of-insulin-pen-devices-and-disposable-plastic-syringes-simplicity-safety-convenience-and-cost-differences
#7
Ripudaman Singh, Clarence Samuel, Jubbin J Jacob
Context: Managing diabetes efficiently demands a simple, safe, convenient and economical therapy. This study was done to understand the simplicity, safety, convenience and cost effectiveness of using pen versus syringe devices in patients on long-term insulin therapy. Design: This prospective observational study was conducted at the endocrine outpatient department of a universityaffiliated teaching hospital in North India. The investigator interviewed patients using a self-made questionnaire after obtaining consent; patients were scored based on their answers...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29922350/mind-body-interactions-and-mindfulness-meditation-in-diabetes
#8
REVIEW
Gagan Priya, Sanjay Kalra
Diabetes is associated with significant psychological distress. It is, therefore, important to ensure the physical and emotional as well as psychosocial wellbeing of individuals living with diabetes. Meditation-based strategies have been evaluated for their complementary role in several chronic disorders including depression, anxiety, obesity, hypertension, cardiovascular disease and diabetes. The practice of meditation is associated with reduction in stress and negative emotions and improvements in patient attitude, health-related behaviour and coping skills...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29922349/a-retrospective-review-of-the-clinical-characteristics-and-blood-glucose-data-from-cellnovo-system-users-using-data-collected-from-the-cellnovo-online-platform
#9
REVIEW
Olivia Hautier-Suply, Yasmin Friedmann, Julian Shapley
Technological advances have led to innovative insulin delivery systems for patients with type 1 diabetes mellitus. In particular, the combination of miniature engineering and software algorithms contained in continuous subcutaneous insulin infusion (CSII) system pumps provide the user and the healthcare practitioner with an opportunity to review and adjust blood glucose (BG) levels according to system feedback, and to modify or programme their regimen according to their needs. While CSII pumps record a number of data parameters such as BG level, carbohydrate intake, activity and insulin delivered, these data are generally 'locked in' and can only be accessed by uploading to a cloud-based system, thus information is not contemporaneous...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29917198/an-analysis-of-cognitive-functioning-of-children-and-youth-with-type-1-diabetes-t1dm-in-the-context-of-glycemic-control
#10
M Stanisławska-Kubiak, E Mojs, R W Wójciak, B Piasecki, M Matecka, J Sokalski, P Kopczyński, P Fichna
OBJECTIVE: The aim of the study was to evaluate the cognitive functioning of children and youth with type 1 diabetes (T1DM). PATIENTS AND METHODS: The study included 68 children with type 1 diabetes, aged 6-17 years, divided into 3 groups according to the level of glycated hemoglobin (HbA1c): group 1: HbA1c ≤ 6.0-7.5%; group 2: HbA1c 7.6-8.5%; group 3: HbA1c over 8.6%. Wechsler's intelligence scale (WISC-R), the Trail of 10 words and Brickenkamp's and Zillmer's d2 Test of Attention were used to assess cognitive functioning...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29916111/do-probiotics-effectively-ameliorate-glycemic-control-during-gestational-diabetes-a-systematic-review
#11
REVIEW
Suelen Dallanora, Yasmin Medeiros de Souza, Rúbia Garcia Deon, Clare A Tracey, Ana Amélia Freitas-Vilela, Luiz Fernando Wurdig Roesch, Roberta Hack Mendes
BACKGROUND: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. The aim of this work was to systematically review all studies in which probiotic supplements were used during pregnancy and analyse the effects on GDM. METHODS: The data were collected using the medical subheading (MeSH) terms: ("diabetes, gestational"[MeSH Terms] OR ("diabetes"[All Fields] AND "gestational"[All Fields]) OR "gestational diabetes"[All Fields] OR ("gestational"[All Fields] AND "diabetes"[All Fields])) AND ("probiotics"[MeSH Terms] OR "probiotics"[All Fields])...
June 18, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29915538/efficacy-and-safety-of-once-weekly-semaglutide-for-the-treatment-of-type-2-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
Fang-Hong Shi, Hao Li, Min Cui, Zai-Li Zhang, Zhi-Chun Gu, Xiao-Yan Liu
Background: Semaglutide, a newly once-weekly glucagon like peptide-1 (GLP-1) receptor agonist, has showed a favorable effect on glycaemic control and weight reduction in type 2 diabetes mellitus (T2DM). This meta-analysis was conducted to evaluate the clinical efficacy and safety of semaglutide in T2DM. Methods: A comprehensive searching was performed for Phase III randomized controlled trials (RCTs) which reported the efficacy and safety data of semaglutide and other therapies. The efficacy data expressed as weight mean difference (WMD) and the safety data expressed as risk ratios (RRs) were calculated by employing random-effects model...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29912623/saxagliptin-upregulates-nesfatin-1-secretion-and-ameliorates-insulin-resistance-and-metabolic-profiles-in-type-2-diabetes-mellitus
#13
Kuanlin Chen, Tiejun Zhuo, Jian Wang, Qing Mei
BACKGROUND AND AIMS: Saxagliptin as one of dipeptidyl peptidase-4 (DPP-4) inhibitors can effectively improve glycaemic control in type 2 diabetes mellitus, and nesfatin-1 is regarded as a very important factor in regulating feeding behavior and energy homeostasis. In this trial, we observed the effect of saxagliptin on regulating nesfatin-1 secretion and ameliorating insulin resistance and metabolic profiles in type 2 diabetes mellitus. METHODS: One hundred two type 2 diabetes participants (M/F = 48/54) were investigated...
June 18, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29910024/dulaglutide-versus-insulin-glargine-in-patients-with-type-2-diabetes-and-moderate-to-severe-chronic-kidney-disease-award-7-a-multicentre-open-label-randomised-trial
#14
Katherine R Tuttle, Mark C Lakshmanan, Brian Rayner, Robert S Busch, Alan G Zimmermann, D Bradley Woodward, Fady T Botros
BACKGROUND: Many antihyperglycaemic drugs, including insulin, are primarily cleared by the kidneys, restricting treatment options for patients with kidney disease. Dulaglutide is a long-acting glucagon-like peptide-1 receptor agonist that is not cleared by the kidneys, and confers a lower risk of hypoglycaemia than does insulin. We assessed the efficacy and safety of dulaglutide in patients with type 2 diabetes and moderate-to-severe chronic kidney disease. METHODS: AWARD-7 was a multicentre, open-label trial done at 99 sites in nine countries...
June 14, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29909261/temporal-relationships-of-gh-igf-i-and-fructosamine-concentrations-in-pregnant-spanish-purebred-mares-a-substantial-contribution-from-the-hormonal-standpoint
#15
K Satué, M Marcilla, P Medica, C Cravana, E Fazio
Growth hormone (GH) and insulin-like growth factor (IGF-I) exert essential functions to maintain an adequate metabolic activity for correct placental and fetal development. Although fructosamine (FRUCT) is used in clinical evaluation to assess the glycaemic state, the relationships between GH, IGF-I and FRUCT remain unknown in the mare. Therefore, the objectives of this study were to evaluate the relationships among these parameters in pregnant mares. A total of 30 healthy Spanish Purebred mares, with an age range of 9...
May 30, 2018: Theriogenology
https://www.readbyqxmd.com/read/29908020/screening-for-dysglycaemia-using-anthropometric-indices-in-an-adult-population-in-oman
#16
Shyam Sundar Ganguly, Kamalesh Sarkar, Samir Al-Adawi, Abdul Aziz Al-Mahrezi
Background: A previous community-based cross-sectional survey conducted in a semi-urban community revealed that 44% of people aged 18+ years manifest dysglycaemia, which appears to echo the national trend. There is lack of studies examining the role of anthropometric indices in people with dysglycaemia. Aim: We explored the screening ability of anthropometric indices, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) to detect dysglycaemia in the adult Omani population based on a community-based survey conducted in 2005...
June 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29903525/impacts-of-self-management-education-on-glycaemic-control-in-patients-with-type-2-diabetes-mellitus
#17
Deldar Morad Abdulah, Alan Bapeer Hassan, Farsat Saeed Saadi, Ary Habeeb Mohammed
OBJECTIVES: Dietary and physical activity advice have been considered to be seminal ingredients in prevention and management of type 2 diabetes mellitus. In this regard, the impacts of a three-month self-management intervention on glycemic control in patients with type 2 diabetes were examined in the present study. STUDY DESIGN: A Double-arm post-test intervention study. METHODS: In the current post-test intervention study, three two-hour educational sessions on dietary habits and physical activity designed according to Health Belief Model were presented to 16 non-complicated type 2 diabetic patients and their dietary, physical activities, and biochemical outcomes were compared to a 23 patient-control arm in Iraq in 2017...
June 7, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29901829/the-relationship-of-type-1-diabetes-self-management-barriers-to-child-and-parent-quality-of-life-a-us-cross-sectional-study
#18
N Saoji, M Palta, H N Young, M A Moreno, V Rajamanickam, E D Cox
AIM: Families of children and adolescents with Type 1 diabetes experience self-management challenges that negatively impact diabetes control. This study assesses whether self-management challenges are also associated with quality of life (QOL) for children and adolescents with Type 1 diabetes and their parents. METHODS: Children aged 8-12 years (n = 135), adolescents aged 13-16 years (n = 132) and their parents completed QOL assessments (diabetes-specific QOL from the PedsQL Diabetes Module or the Family Impact Module, both scaled 0-100) and a validated survey of up to six self-management barriers [PRISM; scaled 1 (low) to 5 (high)]...
June 14, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29901826/use-of-point-of-care-hba-1c-measurement-to-estimate-the-level-of-undiagnosed-diabetes-mellitus-among-67-year-old-participants-in-a-cardiovascular-screening-programme-in-the-municipality-of-viborg-denmark
#19
J W Andersen, M Dahl, K B Yderstraede, A Hoegh
AIMS: To determine the prevalence of unidentified diabetes mellitus among 67-year-olds in Denmark participating in a screening programme focusing on cardiovascular disease and diabetes, and to describe glycaemic levels in individuals according to point-of-care HbA1c combined with self-reported diabetes status. METHODS: In this cross-sectional, retrospective, population-based study, all people aged 67 years living in the Viborg municipality were invited to take part in the Viborg Inter-sectorial Screening Programme (VISP), which focuses on cardiovascular disease and diabetes...
June 14, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29898267/adherence-to-medication-glycaemic-control-and-hospital-attendance-in-young-adults-with-type-2-diabetes
#20
Shalini Kunasegaran, Junaid Beig, Manish Khanolkar, Tim Cundy
Type 2 diabetes is becoming common among people in their 20s and 30s. Glycaemic control is suboptimal in this group and is associated with poor medication adherence. We studied medication adherence over a 24-month period in all diabetes clinic registrants (n = 266) between the ages of 18 and 39 years. We reviewed their glycaemic control using mean HbA1c over the study period and examined hospital records to determine the number of hospital attendances during this time. We found that less than half the group (47%) had good adherence (>90%) and 21% of the group had very poor adherence (<50%)...
June 2018: Internal Medicine Journal
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