keyword
https://read.qxmd.com/read/38482442/wtap-mediated-abnormal-m6a-modification-promotes-cancer-progression-by-remodeling-the-tumor-microenvironment-bibliometric-and-database-analyses
#21
JOURNAL ARTICLE
Yumeng Du, Lihua Huang, Mao Long, Xin Wu, Jinglei Miao
BACKGROUND: Wilms' tumor 1 associated protein (WTAP) is an essential component of the m6A methyltransferase complex. The research on WTAP has been continuously developed and promoted in recent years. It is needed to make systematic specific bibliometric and database analyses on WTAP, to identify the cooperation and impact of authors, countries, institutions and journals, to evaluate the knowledge base and find the hotspot trends, and to detect the emerging topics regarding WTAP research...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38471332/public-expenditure-on-health-care-and-the-incidence-of-non-communicable-diseases-ncds-in-china-from-2008-to-2018
#22
JOURNAL ARTICLE
Zhixin Feng, Xiaoting Liu, Wei Yang, David R Phillips
OBJECTIVES: This study investigates whether differences in individual-level and provincial-level health funding could explain or mitigate health inequalities among older people in terms of non-communicable diseases within a population served by fragmented health insurance schemes. STUDY DESIGN: A national repeated cross-sectional analysis was done of the 2008, 2011, 2014, and 2018 Chinese Longitudinal Healthy Longevity Surveys. These provided a total of 44,623 persons aged 60 and over...
March 5, 2024: Maturitas
https://read.qxmd.com/read/38464986/mortality-after-alcohol-septal-ablation-vs-septal-myectomy-in-patients-with-obstructive-hypertrophic-cardiomyopathy
#23
JOURNAL ARTICLE
Risako Yasuda, Itsuki Osawa, Tadahiro Goto, Kohei Hasegawa, Michael A Fifer, Albree Tower-Rader, Muredach P Reilly, Mathew S Maurer, Yanling Zhao, Hiroo Takayama, Yuichi J Shimada
Background: Alcohol septal ablation (ASA) and septal myectomy (SM) are 2 options for septal reduction therapy (SRT) to treat medication-resistant symptomatic obstructive hypertrophic cardiomyopathy (HCM). Because differences in mortality rates after these different SRT methods have not been extensively investigated in real-world settings, in this study compared the 1-year mortality rates after ASA and SM using population-based database. Methods and Results: Utilizing New York Statewide Planning and Research Cooperative System (SPARCS) data from 2005 to 2016, we performed a comparative effectiveness study of ASA vs...
March 8, 2024: Circulation reports
https://read.qxmd.com/read/38456938/the-emergence-of-the-medical-university-of-vienna-20%C3%A2-years-ago
#24
JOURNAL ARTICLE
Wolfgang Schütz, Markus Grimm
At the beginning of the 2000s the Austrian public universities were characterized by staffing rigidities, little competitive research, outdated study curricula and free access to all fields of study, the latter combined with high dropout rates and long study durations. As a countermeasure the universities were granted full legal capacity. For new employees the status of civil servants was herewith cancelled and, being now subject to the Employment Act, tenured employments for anyone who wanted to stay at the university were no longer possible...
March 8, 2024: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/38449521/a-20-year-overview-of-fertility-preservation-in-boys-new-insights-gained-through-a-comprehensive-international-survey
#25
JOURNAL ARTICLE
Kathleen Duffin, Nina Neuhaus, Claus Yding Andersen, Virginie Barraud-Lange, Aude Braye, Cristina Eguizabal, Aurélie Feraille, Jill P Ginsberg, Debra Gook, Ellen Goossens, Kirsi Jahnukainen, Yasmin Jayasinghe, Victoria Keros, Sabine Kliesch, Sheila Lane, Callista L Mulder, Kyle E Orwig, Ans M M van Pelt, Catherine Poirot, Michael P Rimmer, Nathalie Rives, Hooman Sadri-Ardekani, Myriam Safrai, Stefan Schlatt, Jan-Bernd Stukenborg, Marianne D van de Wetering, Christine Wyns, Rod T Mitchell
STUDY QUESTION: Twenty years after the inception of the first fertility preservation programme for pre-pubertal boys, what are the current international practices with regard to cryopreservation of immature testicular tissue? SUMMARY ANSWER: Worldwide, testicular tissue has been cryopreserved from over 3000 boys under the age of 18 years for a variety of malignant and non-malignant indications; there is variability in practices related to eligibility, clinical assessment, storage, and funding...
2024: Human Reproduction Open
https://read.qxmd.com/read/38441941/impact-of-traditional-and-new-media-on-smoking-intentions-and-behaviors-secondary-analysis-of-tasmania-s-tobacco-control-mass-media-campaign-program-2019-2021
#26
JOURNAL ARTICLE
James Kite, Anne Grunseit, Glenn Mitchell, Pip Cooper, Lilian Chan, Bo-Huei Huang, Margaret Thomas, Blythe O'Hara, Abby Smith
BACKGROUND: Tasmania, the smallest state by population in Australia, has a comprehensive tobacco control mass media campaign program that includes traditional (eg, television) and "new" channels (eg, social media), run by Quit Tasmania. The campaign targets adult smokers, in particular men aged 18-44 years, and people from low socioeconomic areas. OBJECTIVE: This study assesses the impact of the 2019-2021 campaign program on smokers' awareness of the campaign program, use of Quitline, and smoking-related intentions and behaviors...
March 5, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38432931/-contribution-to-pharmacy-pharmacist-education-through-writing
#27
JOURNAL ARTICLE
Hideaki Natsugari
The Education Award of the Pharmaceutical Society of Japan (PSJ) was conferred for "Contribution to pharmacy/pharmacist education through writing on organic chemistry." The award-winning activities were described in three parts section 1-3. Section 1 Importance of Research and Education in Organic Chemistry: In this section, it is explained that organic chemistry serves as the fundamental basis for a wide range of natural science disciplines studied in pharmaceutical departments. It emphasizes that having a solid foundation in organic chemistry is essential for pharmacists to understand pharmaceuticals...
2024: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://read.qxmd.com/read/38429749/temporal-spatial-distribution-characteristics-and-associated-socioeconomic-factors-of-visiting-frequency-for-rural-patients-with-hypertension-in-fujian-province-southeast-china
#28
JOURNAL ARTICLE
Rong Fu, Zhi Huang, Yulan Lin, Xuwei Tang, Zhenquan Zheng, Zhijian Hu
BACKGROUND: Regular follow-up and medication can effectively reduce the risk of adverse outcomes for patients with hypertension. This study aimed to explore the temporal-spatial distribution characteristics and associated socioeconomic factors of visiting frequency for rural patients with hypertension in Fujian province from 2011 to 2016. METHODS: The medical records of patients with hypertension were abstracted from the database of New Rural Cooperative Medical Scheme...
March 1, 2024: BMC Public Health
https://read.qxmd.com/read/38418641/disclosure-orthodontic-and-tmd%C3%A2-%C3%A2-new-study
#29
JOURNAL ARTICLE
Larry Z Lockerman
DESIGN: Cooperative analysis of participants and controls. DATA SOURCE: Wiley Online Library, National Institute of Health, ResearchGate, ScienceDirect, Google Scholar. STUDY SELECTION: Human clinical trials age 18-30 years old, a case-control study included 291 individuals, 192 TMDs and 99 controls. All patients underwent assessment based on a questionnaire and a clinical examination according to Axis I of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD)...
February 28, 2024: Evidence-based Dentistry
https://read.qxmd.com/read/38413915/adapting-the-donabedian-model-in-undergraduate-nursing-education-a-modified-delphi-study
#30
JOURNAL ARTICLE
Marjan Ghofrani, Leila Valizadeh, Vahid Zamanzadeh, Akram Ghahramanian, Ali Janati, Fariba Taleghani
BACKGROUND: Donabedian conceptual and multidimensional framework has been used in several studies in an educational context. In this study, we aimed to adapt the Donabedian three-component model (structure, process, and outcome) in undergraduate nursing education. This conceptual framework provides a comprehensive image of nursing education institutions and can help to evaluate institutions by measuring different aspects of their performance. A comprehensive understanding of the various elements of an educational institution helps to develop a complete, appropriate relevant set of performance indicators...
February 27, 2024: BMC Medical Education
https://read.qxmd.com/read/38410433/use-of-electronic-health-records-to-characterize-patients-with-uncontrolled-hypertension-in-two-large-health-system-networks
#31
Yuan Lu, Ellen C Keeley, Eric Barrette, Rhonda M Cooper-DeHoff, Sanket S Dhruva, Jenny Gaffney, Ginger Gamble, Bonnie Handke, Chenxi Huang, Harlan Krumholz, Caitrin Rowe, Wade Schulz, Kathryn Shaw, Myra Smith, Jennifer Woodard, Patrick Young, Keondae Ervin, Joseph Ross
Background Improving hypertension control is a public health priority. However, consistent identification of uncontrolled hypertension using computable definitions in electronic health records (EHR) across health systems remains uncertain. Methods In this retrospective cohort study, we applied two computable definitions to the EHR data to identify patients with controlled and uncontrolled hypertension and to evaluate differences in characteristics, treatment, and clinical outcomes between these patient populations...
February 15, 2024: Research Square
https://read.qxmd.com/read/38404280/-design-and-innovation-of-a-utility-model-patent-for-tracheal-cannula-fixation-belt
#32
JOURNAL ARTICLE
Hao Liu, Changle Feng, Mengli Yang, Haiyan Xie, Qianqian Liang
Tracheostomy is a very common airway procedure in the treatment of critically ill neurological patients. At present, the traditional tracheal cannula fixation belt is easy to be contaminated, difficult to disinfect, and needs to be replaced regularly. It is prone to infection, skin injury, unplanned extubation and other adverse events, which cannot meet the clinical treatment effect and patient safety management. In order to overcome the above problems, the medical staff of the neurology intensive care unit of Henan Provincial People's Hospital designed a new type of tracheal cannula fixation belt to increase patient comfort and reduce complications, and obtained a National Utility Model Patent of China (ZL 2022 2 0855188...
January 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38395795/-cooperation-between-physicians-and-physios-fosters-trust-you-know-a-qualitative-study-exploring-patients-experience-with-first-contact-physiotherapy-for-low-back-pain-in-french-primary-care
#33
JOURNAL ARTICLE
Amélie Kechichian, Dylan Pommier, Léo Druart, Véronique Lowry, Nicolas Pinsault, François Desmeules
BACKGROUND: Physiotherapists working in collaboration with family physicians in French multidisciplinary primary healthcare clinics are now able to manage acute low back pain patients as first-contact practitioners in advanced practice roles. This includes medical act delegation such as making a medical diagnosis and prescribing medication. The aim of this study is to explore patients' experience and perceptions when attending a first-contact physiotherapist (FCP) in an advanced practice collaborative primary care model for acute low back pain (LBP)...
February 23, 2024: BMC Prim Care
https://read.qxmd.com/read/38386978/long-term-treatment-with-rilzabrutinib-in-patients-with-immune-thrombocytopenia
#34
JOURNAL ARTICLE
David J Kuter, Jiri Mayer, Merlin Efraim, Lachezar H Bogdanov, Ross Ian Baker, Zane S Kaplan, Mamta Garg, Marek Trneny, Philip Y Choi, A J Gerard Jansen, Vickie McDonald, Robert J Bird, Jaromir Gumulec, Milan Kostal, Terry Gernsheimer, Waleed Ghanima, Ahmed Abd Almalik Daak, Nichola Cooper
Immune thrombocytopenia (ITP) is an autoimmune disease associated with autoantibody-mediated platelet destruction and impaired platelet production, resulting in thrombocytopenia and a predisposition to bleeding. The ongoing, global phase 1/2 study showed that rilzabrutinib, a Bruton tyrosine kinase inhibitor specifically developed to treat autoimmune disorders, could be an efficacious and well-tolerated treatment for ITP. Clinical activity, durability of response, and safety were evaluated in 16 responding patients who continued rilzabrutinib 400 mg twice daily in the long-term extension (LTE) study...
February 22, 2024: Blood Advances
https://read.qxmd.com/read/38380258/increasing-the-precision-of-simulated-percutaneous-dilatational-tracheostomy-a-pilot-prototype-device-development-study
#35
JOURNAL ARTICLE
Athia Haron, Lutong Li, Eryl A Davies, Peter D G Alexander, Brendan A McGrath, Glen Cooper, Andrew Weightman
Percutaneous dilatational tracheostomy (PDT) is a bedside medical procedure which sites a new tracheostomy tube in the front of the neck. The critical first step is accurate placement of a needle through the neck tissues into the trachea. Misplacement occurs in around 5% of insertions, causing morbidity, mortality, and delays to recovery. We aimed to develop and evaluate a prototype medical device to improve precision of initial PDT-needle insertion. The Guidance for Tracheostomy (GiFT) system communicates the relative locations of intra-tracheal target sensor and PDT-needle sensor to the operator...
March 15, 2024: IScience
https://read.qxmd.com/read/38379957/representative-public-health-surveys-pose-several-challenges-lessons-learned-across-9-communities-during-the-covid-19-pandemic
#36
JOURNAL ARTICLE
Jeanne W Lawless, Diego G Diel, Bettina Wagner, Kevin J Cummings, Genevive R Meredith, Lara Parrilla, Elizabeth F Plocharczyk, Robert Lawlis, Samantha Hillson, Benjamin D Dalziel, Jeffrey W Bethel, Jane Lubchenco, Katherine R McLaughlin, Roy Haggerty, Kathryn A Higley, F Javier Nieto, Tyler S Radniecki, Christine Kelly, Justin L Sanders, Casey L Cazer
Community surveillance surveys offer an opportunity to obtain important and timely public health information that may help local municipalities guide their response to public health threats. The objective of this paper is to present approaches, challenges, and solutions from SARS-CoV-2 surveillance surveys conducted in different settings by 2 research teams. For rapid assessment of a representative sample, a 2-stage cluster sampling design was developed by an interdisciplinary team of researchers at Oregon State University between April 2020 and June 2021 across 6 Oregon communities...
April 2024: AJPM Focus
https://read.qxmd.com/read/38366769/using-clinical-simulation-to-assess-a-new-paediatric-escalation-system-education-package-empirical-research-mixed-methods
#37
JOURNAL ARTICLE
Alannah Cooper, Rebecca Iten, Gavin D Leslie, David Barrett, Marguerite Lane, Jonathon Mould, Prasanthy Hamsanathan, Scott Stokes, Pania Falconer, Margaret Wood, Samantha Cheesman, Fenella J Gill
AIM: The aim of the study was to assess the suitability of an online education package to prepare health professionals to use a new paediatric early warning system. DESIGN: Quasi-experimental mixed methods using co-production. METHODS: Participants completed the Package and participated in up to four clinical scenarios. Data were collected using self-report surveys, and during clinical scenarios; escalation of care, documentation, family involvement, communication handovers were assessed, and recorded debriefings were thematically analysed...
February 2024: Nursing Open
https://read.qxmd.com/read/38346831/-heart-failure-cooperation-protocol-a-new-way-of-thinking-about-the-care-of-heart-failure-patients
#38
REVIEW
Thibaut Soler
To meet the care needs of heart failure patients, a nationwide cooperation protocol has been developed. This heart failure cooperation protocol (PCIC) enables nurses to acquire new skills by delegating medical acts.
February 2024: Revue de L'infirmière
https://read.qxmd.com/read/38335402/obstetric-service-demand-is-the-main-health-need-of-the-vietnamese-population-in-guangxi-china-a-cross-sectional-study
#39
JOURNAL ARTICLE
Zhini Lan, Xiaoqiu Wu, Jiefang Huang, Cuizhu Pan, Jingzhen Lai, Xia Liang
China has become an emerging destination for international migration, especially in some Association of South East Asian Nations countries, but the situation of migrants seeking medical care in China remains unclear. A retrospective cross-sectional study was conducted in a hospital in Chongzuo, which provides medical services for foreigners, to investigate the situation of Vietnamese people seeking health care in Guangxi, China. Vietnamese patients who visited the hospital between 2018 and 2020 were included in the study...
February 9, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38333366/the-safety-and-immunogenicity-of-vaccines-administered-to-pregnant-women-living-with-hiv-a-systematic-review-and-meta-analysis
#40
JOURNAL ARTICLE
Eve Nakabembe, Jo Cooper, Kyle Amaral, Valerie Tusubira, Yingfen Hsia, Bahaa Abu-Raya, Musa Sekikubo, Annettee Nakimuli, Manish Sadarangani, Kirsty Le Doare
BACKGROUND: Human Immunodeficiency Virus (HIV)-exposed uninfected (HEU) infants have a higher burden of infectious diseases related morbidity and mortality compared with HIV-unexposed uninfected (HUU). Immunization of pregnant women living with HIV (PWLWH) could reduce the severity and burden of infectious diseases for HEU in early infancy. METHODS: We conducted a systematic review of safety and immunogenicity of vaccines administered to PWLWH and meta-analyses to test the overall effect of immunogenicity comparing pregnant women without HIV (PWWH) to PWLWH...
March 2024: EClinicalMedicine
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