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https://www.readbyqxmd.com/read/28201843/regression-of-liver-fibrosis
#1
Lara Campana, John P Iredale
Liver fibrosis is the final common pathway of chronic or iterative liver damage. Advanced chronic fibrosis is described as cirrhosis with a loss of architecture and attendant functional failure and the development of life-threatening complications. However, compelling evidence from rodent models and human studies indicates that if the injury is removed liver fibrosis is reversible. Hepatocytes, activated hepatic stellate cells, endothelial and immune cells, particularly macrophages, cooperate in the establishment and resolution of liver fibrosis...
February 2017: Seminars in Liver Disease
https://www.readbyqxmd.com/read/28197662/-trends-in-medical-rehabilitation-supply-structure-and-target-groups
#2
Rolf Buschmann-Steinhage
Medical rehabilitation in Germany has been changing continuously since its inception following the Bismarck Legislation. This article describes its development in past years and discusses quantitative and qualitative changes. Central quantitative changes are discussed using the examples of rehabilitation utilisation, spectrum of diseases, setting and follow-up rehabilitation. Important qualitative changes in medical rehabilitation pertain to multiple morbidities, the emphasis on work-related problems in rehabilitative concepts and their implementation, more flexible forms of rehabilitation, prevention, rehabilitation for people from other countries, mobile rehabilitation and rehabilitation after-care (also with new media)...
February 14, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28165011/mtorc1-independent-tfeb-activation-via-akt-inhibition-promotes-cellular-clearance-in-neurodegenerative-storage-diseases
#3
Michela Palmieri, Rituraj Pal, Hemanth R Nelvagal, Parisa Lotfi, Gary R Stinnett, Michelle L Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V Bondar, Laura Bremner, Usama Saleem, Dennis Y Tse, Deepthi Sanagasetti, Samuel M Wu, Joel R Neilson, Fred A Pereira, Robia G Pautler, George G Rodney, Jonathan D Cooper, Marco Sardiello
Neurodegenerative diseases characterized by aberrant accumulation of undigested cellular components represent unmet medical conditions for which the identification of actionable targets is urgently needed. Here we identify a pharmacologically actionable pathway that controls cellular clearance via Akt modulation of transcription factor EB (TFEB), a master regulator of lysosomal pathways. We show that Akt phosphorylates TFEB at Ser467 and represses TFEB nuclear translocation independently of mechanistic target of rapamycin complex 1 (mTORC1), a known TFEB inhibitor...
February 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28158440/the-inequity-of-inpatient-services-in-rural-areas-and-the-new-type-rural-cooperative-medical-system-nrcms-in-china-repeated-cross-sectional-analysis
#4
Bingbing Pan, Samuel D Towne, Yuxing Chen, ZhaoKang Yuan
No abstract text is available yet for this article.
February 3, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28125930/from-coastal-to-global-the-transnational-flow-of-ayurveda-and-its-relevance-for-indo-african-linkages
#5
Caroline Meier Zu Biesen
Driven by long-standing ties with India, and intertwined with global market interests, a growing influx of materia medica from South Asia is currently emerging in East Africa. To compete at a global level and framed within the language of 'South-South cooperation for mutual benefit', India presents itself as an appropriate exporter of medical products suitable for African clientele. The expansion of India's medical sector into Africa is particularly relevant for Ayurvedic pharmaceuticals. Ayurveda's diaspora into Africa exemplifies the emergence of new health interventions and medical assemblages in a transnationally interconnected world and implies innovative coalitions involved in the complex promotion of local/Global Health industries...
January 26, 2017: Global Public Health
https://www.readbyqxmd.com/read/28121261/occupational-injuries-and-exposures-among-emergency-medical-services-workers
#6
Audrey A Reichard, Suzanne M Marsh, Theresa R Tonozzi, Srinivas Konda, Mirinda A Gormley
OBJECTIVE: Emergency medical services (EMS) workers incur occupational injuries at a higher rate than the general worker population. This study describes the circumstances of occupational injuries and exposures among EMS workers to guide injury prevention efforts. METHODS: The National Institute for Occupational Safety and Health collaborated with the National Highway Traffic Safety Administration to conduct a follow-back survey of injured EMS workers identified from a national sample of hospital emergency departments (EDs) from July 2010 through June 2014...
January 25, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28109347/how-is-physician-work-valued
#7
Jeffrey P Jacobs, Stephen J Lahey, Francis C Nichols, James M Levett, George Gilbert Johnston, Richard K Freeman, James D St Louis, Julie Painter, Courtney Yohe, Cameron D Wright, Kirk R Kanter, John E Mayer, Keith S Naunheim, Jeffrey B Rich, Joseph E Bavaria
Strategies to value physician work continue to evolve. The Society of Thoracic Surgeons and The Society of Thoracic Surgeons National Database have an increasingly important role in this evolution. An understanding of the Current Procedural Terminology (CPT) system (American Medical Association [AMA], Chicago, IL) and the Relative Value Scale Update Committee (RUC) is necessary to comprehend how physician work is valued. In 1965, with the dawn of increasingly complex medical care, immense innovation, and the rollout of Medicare, the need for a common language describing medical services and procedures was recognized as being of critical importance...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28099481/correction-comparing-maternal-services-utilization-and-expense-reimbursement-before-and-after-the-adjustment-of-the-new-rural-cooperative-medical-scheme-policy-in-rural-china
#8
Hua You, Hai Gu, Weiqing Ning, Hua Zhou, Hengjin Dong
[This corrects the article DOI: 10.1371/journal.pone.0158473.].
2017: PloS One
https://www.readbyqxmd.com/read/28092617/supplementation-of-pigs-diet-with-zinc-and-copper-as-alternative-to-conventional-antimicrobials
#9
B Dębski
Modern commercial pig farming systems inflict increased stress in animals, which often leads to various negative changes in the gastro-intestinal tract, especially in the case of piglets. Ban of antibiotics, used as growth promoters, has caused a need for alternatives to conventional antimicrobials in swine diets. Use of pre-/or probiotics, organic acids and plant extracts is often recommended, but it seems that zinc oxide and cooper salts, which were traditionally included in high doses to piglets diet, possess the highest efficacy...
December 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28062578/gmp-synthase-is-required-for-virulence-factor-production-and-infection-by-cryptococcus-neoformans
#10
Jessica L Chitty, Tayla L Tatzenko, Simon J Williams, Y Q Andre E Koh, Elizabeth C Corfield, Mark S Butler, Avril A B Robertson, Matthew A Cooper, Ulrike Kappler, Bostjan Kobe, James A Fraser
Over the last four decades the HIV pandemic and advances in medical treatments that also cause immunosuppression have produced an ever-growing cohort of individuals susceptible to opportunistic pathogens. Of these, AIDS patients are particularly vulnerable to infection by the encapsulated yeast Cryptococcus neoformans Most commonly found in the environment in purine-rich bird guano, C. neoformans experiences a drastic change in nutrient availability during host infection, ultimately disseminating to colonize the purine-poor central nervous system...
January 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28057111/-health-economic-evaluation-of-a-23-value-pneumococcal-polysaccharide-vaccination-pilot-programme-among-elderly-chronic-obstructive-pulmonary-disease-patients-in-china
#11
Y P Qiu, K Zhao, X Li, L W Shi, W D Guo, X R Qi, B Y Sui, R M Zhou
Objective: From the perspective of health economics, to evaluate 23 pneumococcal polysaccharide vaccination programme among chronic obstructive pulmonary disease (COPD) patient. Methods: In the pilot counties of the project of integrated care pathway for COPD patient (Hanbin district of Hanzhong city in Shanxi Province, Qianjian district of Qingqing city, Huandao district of Qindao city in Shangdong Province, Wen county of Jiaozuo city in Henan Province), information of insurance participants of New Rural Cooperative Medical System (NRCS) was collected by local NRCM information system, which included general information as well as records of medical care and medical fee...
December 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28052775/does-the-new-cooperative-medical-scheme-reduce-inequality-in-catastrophic-health-expenditure-in-rural-china
#12
Na Guo, Tor Iversen, Mingshan Lu, Jian Wang, Luwen Shi
BACKGROUND: In 2003, the New Cooperative Medical Scheme (NCMS) was introduced in China to re-establish health insurance for the country's vast rural population. In addition, the coverage of NCMS has been expanding after the new health care reform launched in 2009. This study aims to examine whether the NCMS and its recent expansion have reached the goal of reducing the risk and inequality of catastrophic health spending for rural residents in China. METHODS: We conducted a face-to-face household survey in three counties of the Shandong province in 2009 and 2012...
November 14, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/28049149/rela-mutant-enterococcus-faecium-with-multiantibiotic-tolerance-arising-in-an-immunocompromised-host
#13
Erin S Honsa, Vaughn S Cooper, Mohammed N Mhaissen, Matthew Frank, Jessica Shaker, Amy Iverson, Jeffrey Rubnitz, Randall T Hayden, Richard E Lee, Charles O Rock, Elaine I Tuomanen, Joshua Wolf, Jason W Rosch
: Serious bacterial infections in immunocompromised patients require highly effective antibacterial therapy for cure, and thus, this setting may reveal novel mechanisms by which bacteria circumvent antibiotics in the absence of immune pressure. Here, an infant with leukemia developed vancomycin-resistant Enterococcus faecium (VRE) bacteremia that persisted for 26 days despite appropriate antibiotic therapy. Sequencing of 22 consecutive VRE isolates identified the emergence of a single missense mutation (L152F) in relA, which constitutively activated the stringent response, resulting in elevated baseline levels of the alarmone guanosine tetraphosphate (ppGpp)...
January 3, 2017: MBio
https://www.readbyqxmd.com/read/28047795/su-f-e-11-perception-and-implementation-of-collaborative-documentation-technologies-among-medical-physics-educators-and-industry-professionals-a-current-practice-survey
#14
Angela N Johnson
PURPOSE: Collaboration on documents and manuscripts plays a central role in conveying medical physics concepts between interdisciplinary teams, necessary for knowledge-building, acquiring funding, and translating scientific concepts to applied medical solutions. Conventional tools and emerging internet-based solutions are used in generating and disseminating physics documents among teams. This research aimed to gain insights on how medical physics professionals and educators are using collaborative documentation software and team practices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28038483/a-new-museum-within-the-croatian-academy-of-sciences-and-arts-and-the-first-of-its-kind-in-croatia-the-croatian-museum-of-medicine-and-pharmacy
#15
EDITORIAL
Silvija Brkić Midžić
One decade has passed since the Croatian Academy of Sciences and Arts initiated the foundation of the Croatian Museum of Medicine and Pharmacy, providing it with the location of 300m in Gundulićeva Street 24 in Zagreb. The foundation of the Museum was the Collection of the History of Medicine and Pharmacy which was in safekeeping of the Division for the History of Medical Sciences of the Croatian Academy of Sciences and Arts in Zagreb for more than fifty years. It was put together by combining the materials from two collections: the pharmaceutical-historical collection in Zagreb, which subsequently became the collection of the Institute for the History of Pharmacy, and the one of the Croatian Medical History Museum, which was established in 1944 within the Croatian Medical Association...
December 2016: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/28035494/antiresorptive-agent-related-osteonecrosis-of-the-jaw-position-paper-2017-of-the-japanese-allied-committee-on-osteonecrosis-of-the-jaw
#16
Toshiyuki Yoneda, Hiroshi Hagino, Toshitsugu Sugimoto, Hiroaki Ohta, Shunji Takahashi, Satoshi Soen, Akira Taguchi, Toshihiko Nagata, Masahiro Urade, Takahiko Shibahara, Satoru Toyosawa
Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) is an intractable, though rare, complication in cancer patients with bone metastases and patients with osteoporosis who are treated with antiresorptive agents, including bisphosphonates and denosumab. Despite the more than 10 years that have passed since the first cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ) were reported, our understanding of the epidemiology and pathophysiology of ARONJ remains limited, and data supported by evidence-based medicine are still sparse...
January 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28028435/age-or-health-status-which-influences-medical-insurance-enrollment-greater
#17
Wei Xu, Gong-Jie Cai, Guan-Nan Li, Jing-Jing Cao, Qiong-Hua Shi, Jie Bai
BACKGROUND: The New Cooperative Medical Scheme (NCMS) for peasantries implemented in 2003 and the Urban Resident Basic Medical Insurance (URBMI) for the urban unemployed implemented in 2007 have many similarities. They both apply the financing mode of individual premiums plus government's subsidies, and the voluntary enrollment. The Chinese government plans to integrate these two systems and build a unified basic medical insurance system for the unemployed in order to achieve the medical equity and increase the general health level...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/28025610/evidence-gaps-in-ent-surgery-a-qualitative-survey
#18
REVIEW
Jan Löhler, B Akcicek, F Müller, G Dreier, J J Meerpohl, W Vach, J A Werner
Introduction: As in other disciplines, the burgeoning knowledge in ENT medicine long ago surpassed our ability to adequately absorb it and maintain a proper overview. This can give rise to actual or assumed evidence gaps that can impede the progress of the discipline and evidence-based treatment of patients. Clinics and medical practices also hold to traditional doctrines that shape day-to-day medicine, without these schools being challenged based on evidence. Methods: Between February and June 2015, 160 ENT clinics, including 34 university hospitals, and 2,670 ENT practices took part in a two-arm online survey on existing or perceived evidentiary gaps in ENT medicine using a previously developed questionnaire...
2016: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/28005003/pleasant-preventing-and-lessening-exacerbations-of-asthma-in-school-age-children-associated-with-a-new-term-a-cluster-randomised-controlled-trial-and-economic-evaluation
#19
Steven A Julious, Michelle J Horspool, Sarah Davis, Mike Bradburn, Paul Norman, Neil Shephard, Cindy L Cooper, W Henry Smithson, Jonathan Boote, Heather Elphick, Amanda Loban, Matthew Franklin, Wei Sun Kua, Robin May, Jennifer Campbell, Rachael Williams, Saleema Rex, Oscar Bortolami
BACKGROUND: Asthma episodes and deaths are known to be seasonal. A number of reports have shown peaks in asthma episodes in school-aged children associated with the return to school following the summer vacation. A fall in prescription collection in the month of August has been observed, and was associated with an increase in the number of unscheduled contacts after the return to school in September. OBJECTIVE: The primary objective of the study was to assess whether or not a NHS-delivered public health intervention reduces the September peak in unscheduled medical contacts...
December 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27994123/the-origins-scaling-and-loss-of-tetrapod-digits
#20
REVIEW
Aditya Saxena, Matthew Towers, Kimberly L Cooper
Many of the great morphologists of the nineteenth century marvelled at similarities between the limbs of diverse species, and Charles Darwin noted these homologies as significant supporting evidence for descent with modification from a common ancestor. Sir Richard Owen also took great care to highlight each of the elements of the forelimb and hindlimb in a multitude of species with focused attention on the homology between the hoof of the horse and the middle digit of man. The ensuing decades brought about a convergence of palaeontology, experimental embryology and molecular biology to lend further support to the homologies of tetrapod limbs and their developmental origins...
February 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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