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https://www.readbyqxmd.com/read/29773775/case-study-in-international-cooperation-cuba-s-molecular-immunology-center-and-roswell-park-cancer-institute
#1
Rachel Evans, Mary Reid, Brahm Segal, Scott I Abrams, Kelvin Lee
In 1961, the USA severed diplomatic relations with Cuba, and in 1962 an embargo was imposed on trade and financial relations with that country. It was not until five decades later that the USA and Cuba would reestablish relations. This opened the way for the New York State Trade Mission to Cuba in April 2015, during which Cuba's Molecular Immunology Center and Buffalo, New York's Roswell Park Cancer Institute signed a formal agreement that would set in motion biotechnology research collaboration to address one of the most important causes of death in both countries...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29767345/metastatic-breast-cancer-collateral-damage-project-mbccd-scale-development-and-preliminary-results-of-the-survey-of-health-impact-needs-and-experiences-shine
#2
Timothy J Williamson, Susan M Love, Jessica N Clague DeHart, Alexandra Jorge-Miller, Leah Eshraghi, Heather Cooper Ortner, Annette L Stanton
PURPOSE: Until recently, people with metastatic breast cancer (MBC) had a very poor prognosis. New treatment approaches have prolonged the time that people with MBC live, but their quality of life has received less attention. Consequently, the needs and concerns across financial, vocational, psychological, social, and physical domains in MBC patients are poorly understood-particularly regarding the collateral damage or longer-term, life-altering impacts of MBC and its treatments. This study's aims were to characterize MBC-related collateral damage, identify groups most likely to experience collateral damage, and examine its associations with psychological health, illness management, and health behaviors...
May 16, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29764177/solidarity-and-compassion-prisoners-as-hospice-volunteers-in-poland
#3
Piotr Krakowiak, Renata Deka, Anna Janowicz
Democracy in Eastern Europe arrived after a long fight with a communist regime, and the activities of medical volunteers have been developing in opposition to the existing then in Poland mentality called Homo Sovieticus. From 1981 onwards the Polish Hospice Movement there was inspired by practitioners and international experiences brought by visits of Dr. Cicely Saunders. The history of modern end-of-life care in Poland was connected to caring communities, which could be called compassionate, because of the volunteering of all hospice team members...
April 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29748753/electrospun-poly-%C3%AE%C2%B5-caprolactone-matrices-containing-silver-sulfadiazine-complexed-with-%C3%AE-cyclodextrin-as-a-new-pharmaceutical-dosage-form-to-wound-healing-preliminary-physicochemical-and-biological-evaluation
#4
Sarah Oliveira Lamas Souza, Monique Alvarenga Pinto Cotrim, Rodrigo Lambert Oréfice, Suzana Gonçalves Carvalho, Jessyca Aparecida Paes Dutra, Francisco de Paula Careta, Juliana Alves Resende, Janaina Cecília Oliveira Villanova
Cooperation between researchers in the areas of medical, pharmaceutical and materials science has facilitated the development of pharmaceutical dosage forms that elicit therapeutic effects and protective action with a single product. In addition to optimizing pharmacologic action, such dosage forms provide greater patient comfort and increase success and treatment compliance. In the present work, we prepared semipermeable bioactive electrospun fibers for use as wound dressings containing silver sulfadiazine complexed with β-cyclodextrin in a poly(Ɛ-caprolactone) nanofiber matrix aiming to reduce the direct contact between silver and skin and to modulate the drug release...
May 10, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29739411/locum-physicians-professional-ethos-a-qualitative-interview-study-from-germany
#5
Sabine Salloch, Birgit Apitzsch, Maximiliane Wilkesmann, Caroline Ruiner
BACKGROUND: In contrast to other countries, the appearance of locum physicians as independent contractors constitutes a rather new phenomenon in the German health care system and emerged out of a growing economization and shortage of medical staff in the hospital sector. Locums are a special type of self-employed professionals who are only temporally embedded in organisational contexts of hospitals, and this might have consequences for their professional practice. Therefore, questions arise regarding how locums perceive their ethical duties as medical professionals...
May 8, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29721654/-physician-assistants-in-surgery-a-young-profession-through-graduates-eyes
#6
Marcus Hoffmann, Silke Arnegger, Bettina Mend, Reinhard Hoffmann, Tanja Marschall
BACKGROUND: In Germany, physician assistant (PA) is a comparatively young profession. The concept paper by the German Medical Association (BÄK) and the Federation of Statutory Health Insurance Physicians (KBV) from 2017 defines the new occupational profile in detail. In contrast, there is hardly any information on the day to day working life of a PA in Germany OBJECTIVE: The aim of this study was to map the employment reality of the PA graduates of the study program of the Baden-Wuerttemberg Cooperative State University Karlsruhe...
May 2, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29720175/challenges-for-the-surgical-capacity-building-of-township-hospitals-among-the-central-china-a-retrospective-study
#7
Zhong Li, Jian Yang, Yue Wu, Zijin Pan, Xiaoqun He, Boyang Li, Liang Zhang
BACKGROUND: China's rapid transition in healthcare service system has posed considerable challenges for the primary care system. Little is known regarding the capacity of township hospitals (THs) to deliver surgical care in rural China with over 600 million lives. We aimed to ascertain its current performance, barriers, and summary lessons for its re-building in central China. METHODS: This study was conducted in four counties from two provinces in central China...
May 2, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29716603/study-on-the-equity-of-medical-services-utilization-for-elderly-enrolled-in-different-basic-social-medical-insurance-systems-in-an-underdeveloped-city-of-southwest-china
#8
Rao Chen, Ning-Xiu Li, Xiang Liu
BACKGROUND: The equity of medical services utilization for elderly individuals enrolled in different basic social medical insurance systems holds significant meaning for social harmony against a background of demographic aging and a growing wealth gap in China. This study is to explore the equity of the three medical insurance systems in southwest China with the aim of providing recommendations for relevant policy. METHODS: A total of 9600 elderly people insured through basic social medical insurance were selected and interviewed with a questionnaire...
May 2, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29713474/the-belgian-commitment-to-pharmaceutical-quality-a-model-policy-to-improve-quality-assurance-of-medicines-available-through-humanitarian-and-development-programs
#9
EDITORIAL
Raffaella Ravinetto, Tim Roosen, Catherine Dujardin
Today, a combination of globalization of pharmaceutical production, lack of regulatory harmonization, and weakness of Medicines Regulatory Authorities, creates the "perfect conditions" for poor-quality medicine to circulate in the global market and to penetrate the less-regulated countries. Medicines regulation is the responsibility of the national regulatory authorities in the recipient country, but in the poorer countries, in practice, the responsibility of supply of quality-assured medicines is often taken by Non-Governmental Organizations and other implementers...
2018: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/29704556/antiretroviral-therapy-treatment-in-australia-comparing-the-australian-hiv-observational-database-using-a-national-representative-database-of-prescription-data
#10
Robin Huang, Kathy Petoumenos, Richard T Gray, Hamish McManus, Nila Dharan, Rebecca Guy, David A Cooper
OBJECTIVES: Cohort studies are often used as a national surveillance tool to monitor trends in HIV treatment and morbidity outcomes. However, there are limited studies validating the accuracy of using cohorts as a representation of the overall HIV-positive population. We compared data from a large Australian HIV-positive cohort study (Australian HIV Observational Database (AHOD)) and a 10% longitudinal sample from Australia's subsidized prescription medication scheme (the Pharmaceutical Benefits Scheme (PBS)) to assess the use of cohorts for providing representative data for surveillance and monitoring purposes...
April 25, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29698644/principles-of-systems-biology-no-28
#11
(no author information available yet)
This month: new principles for engineering cells (Avalos/Toettcher, Li, Wang, Ellis/Stan), the daily rhythms of gene expression in a primate (Cooper/Panda), structure of the nuclear pore by an integrative approach (Rout/Akey/Sali), and scoring Mendelian disease risk using electronic medical records (Denny).
April 25, 2018: Cell Systems
https://www.readbyqxmd.com/read/29684645/challenges-in-pediatric-neuroimaging
#12
REVIEW
Matthew J Barkovich, Yi Li, Rahul S Desikan, A James Barkovich, Duan Xu
Pediatric neuroimaging is challenging due the rapid structural, metabolic, and functional changes that occur in the developing brain. A specially trained team is needed to produce high quality diagnostic images in children, due to their small physical size and immaturity. Patient motion, cooperation and medical condition dictate the methods and equipment used. A customized approach tailored to each child's age and functional status with the appropriate combination of dedicated staff, imaging hardware, and software is key; these range from low-tech techniques, such as feed and swaddle, to specialized small bore MRI scanners, MRI compatible incubators and neonatal head coils...
April 20, 2018: NeuroImage
https://www.readbyqxmd.com/read/29677985/medical-data-analytics-is-not-a-simple-task
#13
František Babič, Michal Vadovský, Ján Paralič
Data analytics represents a new chance for medical diagnosis and treatment to make it more effective and successful. This expectation is not so easy to achieve as it may look like at a first glance. The medical experts, doctors or general practitioners have their own vocabulary, they use specific terms and type of speaking. On the other side, data analysts have to understand the task and to select the right algorithms. The applicability of the results depends on the effectiveness of the interactions between those two worlds...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29664883/should-all-orthopedists-perform-hemiarthroplasty-for-femoral-neck-fractures-a-volume-outcome-analysis
#14
R Carter Clement, Paula D Strassle, Robert F Ostrum
OBJECTIVES: To determine whether very low surgeon and hospital hip arthroplasty volume are associated with unfavorable outcomes following hemiarthroplasty for femoral neck fractures. METHODS: Patients ≥60 years old and who underwent hemiarthroplasty for femoral neck fracture were identified in the New York Statewide Planning and Research Cooperative System data from 2001-2015. Incidence of inpatient mortality and postoperative complications were compared across both surgeon and hospital volume using multivariable Cox proportional hazards regression, adjusting for clinical and demographic factors...
April 3, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29658441/efficacy-of-transcranial-direct-current-stimulation-combined-with-cognitive-training-in-the-treatment-of-apathy-in-patients-with-alzheimer-s-disease-study-protocol-for-a-randomized-trial
#15
Jean-Paul Nguyen, Claire Boutoleau-Bretonniere, Jean-Pascal Lefaucheur, Alcira Suarez, Helene Gaillard, Guillaume Chapelet, Sebastien Abad, Aurelien Van Langhenhove, Julian Nizard, Laure de Decker
BACKGROUND: Apathy, commonly defined as loss of motivation, is a symptom frequently encountered in Alzheimer's disease (AD). The treatment of apathy remains challenging in the absence of any truly effective medications. Transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) can improve cognitive disorders, but do not appear to improve apathy. Isolated cognitive training also appears to have no effect on apathy. We propose to test the efficacy of a new procedure for the treatment of apathy in AD patients consisting of a combination of tDCS and cognitive training, based on the latest guidelines for the design of therapeutic trials in this field...
April 16, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29655551/medical-and-entomological-malarial-interventions-a-comparison-and-synergy-of-two-control-measures-using-a-ross-macdonald-model-variant-and-openmalaria-simulation
#16
R C Elliott, D L Smith, D Echodu
Using an established Ross/Macdonald model variant for mosquito-born parasite transmission, we extend the formalism to simply incorporate time-dependent control measures. In particular, two interventions are considered, mass drug administration (MDA) and indoor residual spraying (IRS), whose individual intensities during their respective campaigns are set to the same intervention-reduced reproductive number R0 . The impacts of these interventions, measured as each campaign's ability over time to reduce infections in a community, are found based on the transmission setting, coverage, and their associated durations...
April 12, 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/29650451/hiv-incidence-in-western-kenya-during-scale-up-of-antiretroviral-therapy-and-voluntary-medical-male-circumcision-a-population-based-cohort-analysis
#17
Martien W Borgdorff, Daniel Kwaro, David Obor, George Otieno, Viviane Kamire, Frederick Odongo, Patrick Owuor, Jacques Muthusi, Lisa A Mills, Rachael Joseph, Mary E Schmitz, Peter W Young, Emily Zielinski-Gutierrez, Kevin M De Cock
BACKGROUND: In Kenya, coverage of antiretroviral therapy (ART) among people with HIV infection has increased from 7% in 2006, to 57% in 2016; and, in western Kenya, coverage of voluntary medical male circumcision (VMMC) increased from 45% in 2008, to 72% in 2014. We investigated trends in HIV prevalence and incidence in a high burden area in western Kenya in 2011-16. METHODS: In 2011, 2012, and 2016, population-based surveys were done via a health and demographic surveillance system and home-based counselling and testing in Gem, Siaya County, Kenya, including 28 688, 17 021, and 16 772 individuals aged 15-64 years...
April 9, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29644808/prognostic-evaluation-of-neurological-assessment-of-the-neuro-oncology-scale-in-glioblastoma-patients
#18
Jiwook Lee, Sung Hyun Park, Young Zoon Kim
BACKGROUND: The aims of this study were to investigate the role of the Neurological Assessment of Neuro-Oncology (NANO) scale in predicting the prognosis of patients with glioblastoma, and compare these results to predicted data of the Karnofsky Performance Scale (KPS), and Eastern Cooperative Oncology Group (ECOG)/World Health Organization (WHO) performance status. Additionally, we examined other prognostic factors in glioblastoma patients. METHODS: The medical records of 76 patients with a new diagnosis of histologically ascertained glioblastoma in the period from January 2002 to December 2015 at the authors' institution were retrospectively reviewed...
April 2, 2018: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/29643545/-necessity-and-feasibility-of-data-sharing-of-cohort-studies
#19
Y Yang, H Y Zhao, S Y Zhan
Cohort study is one of the important epidemiological methods which plays an irreplaceable status and role in etiological study. Using cohort study design, we can accurately and continuously collect genetic and environmental information, and identify and validate omics biomarkers to provide evidences for precision public health and medicine. However, results from a new cohort would not be available for at least ten years, as five years would be needed for funding, planning and enrolment, and another five for following up even the earliest analyses of the most common diseases; results for most cancers would take longer, with an unaffordable budget for many research investigators or institutions...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29629286/the-kaleidoscope-model-of-integrative-healthcare-as-a-collaborative-paradigm-for-cardiology-and-chiropractic-a-call-to-action
#20
REVIEW
Daniel J Cohen, Steven Schulman, Charles S Masarsky, Marion Todres-Masarsky
This review article proposes a model of integrative care for cardiovascular patients in institutional settings. We review relevant historic and contemporary examples of medical-chiropractic cooperation and a brief review of the literature illustrating the clinical benefits of chiropractic care for patients with cardiovascular disease. The groundwork proposes a distinct research and clinical practice model incorporating the doctor of chiropractic (D.C.) as a synergistic partner with the medical cardiologist coined the Kaleidoscope Model of Integrative Care (KM)...
March 2018: Integrative Medicine Research
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