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https://www.readbyqxmd.com/read/29351697/roles-of-transit-time-flow-measurement-for-coronary-artery-bypass-surgery
#1
Yoshiyuki Takami, Yasushi Takagi
Transit-time flow measurement (TTFM) has been increasingly applied to detect graft failure during coronary artery bypass grafting (CABG), because TTFM is less invasive, more reproducible, and less time consuming. Many authors have attempted to validate TTFM and to gain the clear cutoff values and algorithm in TTFM to predict graft failure. The TTFM technology has also been shown to be a useful tool to investigate CABG graft flow characteristics and coronary circulation physiology. It is important to recognize the practical roles of TTFM in the cardiac operating room by review and summarize the literatures...
January 19, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29351546/accessing-an-expanded-exposure-science-module-at-the-comparative-toxicogenomics-database
#2
Cynthia J Grondin, Allan Peter Davis, Thomas C Wiegers, Jolene A Wiegers, Carolyn J Mattingly
The Comparative Toxicogenomics Database (CTD; http://ctdbase.org) is a free resource that provides manually curated information on chemical, gene, phenotype, and disease relationships to advance understanding of the effect of environmental exposures on human health. Four core content areas are independently curated: chemical-gene interactions, chemical-disease and gene-disease associations, chemical-phenotype interactions, and environmental exposure data (e.g., effects of chemical stressors on humans). Since releasing exposure data in 2015, we have vastly increased our coverage of chemicals and disease/phenotype outcomes; greatly expanded access to exposure content; added search capability by stressors, cohorts, population demographics, and measured outcomes; and created user-specified displays of content...
January 18, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29351057/global-gene-expression-response-in-mouse-models-of-dna-repair-deficiency-after-gamma-irradiation
#3
Nils Rudqvist, Evagelia C Laiakis, Shanaz A Ghandhi, Suresh Kumar, Jeffrey D Knotts, Mashkura Chowdhury, Albert J Fornace, Sally A Amundson
In the event of an improvised nuclear device or "dirty bomb" in a highly populated area, potentially hundreds of thousands of people will require screening to ensure that exposed individuals receive appropriate treatment. For this reason, there is a need to develop tools for high-throughput radiation biodosimetry. Gene expression represents an emerging approach to biodosimetry and could potentially provide an estimate of both absorbed dose and individual radiation-induced injury. Since approximately 2-4% of humans are thought to be radiosensitive, and would suffer greater radiological injury at a given dose than members of the general population, it is of interest to explore the potential impact of such sensitivity on the biodosimetric gene expression signatures being developed...
January 19, 2018: Radiation Research
https://www.readbyqxmd.com/read/29350873/test-procedures-to-assess-somatosensory-abnormalities-in-individuals-with-peripheral-joint-pain-a-systematic-review-of-psychometric-properties
#4
REVIEW
Abdullah Alqarni, Donald Manlapaz, David Baxter, Steve Tumilty, Ramakrishnan Mani
BACKGROUND: Test procedures that were developed to assess somatosensory abnormalities should possess optimal psychometric properties (PMPs) to be used in clinical practice. The aim of this systematic review is to evaluate the literature to assess the level of evidence for PMPs of test procedures investigated in individuals with peripheral joint pain (PJP). METHODS: A comprehensive electronic literature search was conducted in seven databases from inception to March 2016...
January 19, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29350788/reliability-and-validity-of-the-atopic-dermatitis-symptom-score
#5
Ji Young Lee, Minji Kim, Hea-Kyoung Yang, Hyun Mi Kim, Joongbum Cho, Young-Min Kim, In Seok Lim, Hae-Kwan Cheong, Hye Seung Kim, Insuk Sohn, Jihyun Kim, Kangmo Ahn
BACKGROUND: We have developed the Atopic Dermatitis Symptom Score (ADSS) by which patients or parents can easily assess and record AD symptoms on a daily basis in a smartphone application. The aim of the present study was to evaluate the reliability and validity of the ADSS. METHODS: We enrolled 307 children and adolescents with AD. Parents or caregivers were asked to record daily symptoms of the patients (itching, sleep disturbance, erythema, dryness, oozing, and oedema) using a scale of 0 to 4...
January 19, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29350469/in-vitro-to-in-vivo-benchmark-dose-comparisons-to-inform-risk-assessment-of-quantum-dot-nanomaterials
#6
REVIEW
Brittany A Weldon, William C Griffith, Tomomi Workman, David K Scoville, Terrance J Kavanagh, Elaine M Faustman
Engineered nanomaterials are currently under review for their potential toxicity; however, their use in consumer/commercial products has continued to outpace risk assessments. In vitro methods may be utilized as tools to improve the efficiency of risk assessment approaches. We propose a framework to compare relationships between previously published in vitro and in vivo toxicity assessments of cadmium-selenium containing quantum dots (QDs) using benchmark dose (BMD) and dosimetric assessment methods. Although data were limited this approach was useful for identifying sensitive assays and strains...
January 19, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29350334/the-triglyceride-glucose-index-an-insulin-resistance-marker-in-newborns
#7
Eva Gesteiro, Sara Bastida, Laura Barrios, Francisco J Sánchez-Muniz
The study aims to assess the utility of the triglyceride-glucose index (TyG) as a marker of insulin resistance (IR) in neonates. TyG and the homeostatic model assessment (HOMA-IR) values were compared in 196 singleton, term normoweight and without distress newborns. A Decision Tree procedure (CHAID) was used to classify cases into groups or predict values of a dependent (Ln HOMA-IR) variable. Three nodes were drawn for TyG: ≤ 6.7, > 6.7-7.8 and > 7.8 (p < 0.0001; F = 20.52). The predictability of those TyG values vs HOMA-IR was statistically significant (p < 0...
January 19, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29349876/effectiveness-of-a-body-shape-index-absi-in-predicting-chronic-diseases-and-mortality-a-systematic-review-and-meta-analysis
#8
REVIEW
M Ji, S Zhang, R An
Anthropometric measures are simple, inexpensive, noninvasive tools to assess the risk of morbidity and mortality. This systematic review assessed the performance of A Body Shape Index (ABSI) in predicting hypertension, cardiovascular disease, type 2 diabetes and all-cause mortality and compared the differential predictability between ABSI and two other common anthropometric measures - body mass index and waist circumference. A keyword and reference search were conducted in the PubMed and Web of Science for articles published until 1 November 2017...
January 19, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29349758/is-dcis-overrated
#9
Joshua Feinberg, Rachel Wetstone, Dana Greenstein, Patrick Borgen
Ductal carcinoma in situ (DCIS), the noninvasive form of breast cancer (BC), comprises just over 20% of breast cancer cases diagnosed each year in the USA. Most patients are treated with local excision of the disease followed by whole breast radiation therapy. Total mastectomy is not an uncommon approach, and total mastectomy with a contralateral risk-reducing mastectomy has been on the rise in the past decade. In estrogen receptor-positive disease, patients are often offered endocrine ablative therapy with a selective estrogen receptor modulator or an aromatase inhibitor as both treatment and prevention...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29349733/point-of-care-ultrasound-pocus-of-the-upper-airway
#10
REVIEW
Kong Eric You-Ten, Naveed Siddiqui, Wendy H Teoh, Michael S Kristensen
Airway management is a critical skill in the practice of several medical specialities including anesthesia, emergency medicine, and critical care. Over the years mounting evidence has showed an increasing role of ultrasound (US) in airway management. The objective of this narrative review is to provide an overview of the indications for point-of-care ultrasound (POCUS) of the upper airway. The use of US to guide and assist clinical airway management has potential benefits for both provider and patient. Ultrasound can be utilized to determine airway size and predict the appropriate diameter of single-lumen endotracheal tubes (ETTs), double-lumen ETTs, and tracheostomy tubes...
January 18, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29349592/overview-of-current-and-future-adjuvant-therapy-for-high-risk-localized-renal-cell-carcinoma
#11
REVIEW
Lakshminarayanan Nandagopal, Gurudatta Naik, Guru Sonpavde
High-risk localized renal cell carcinoma represents a therapeutic challenge with high recurrence rates and poor survival with nephrectomy alone. Multiple agents targeting angiogenic and immunologic pathways have demonstrated remarkable efficacy in the metastatic setting but have failed to replicate similar successes in localized disease. Study results with adjuvant anti-angiogenic therapies may have been compromised by the high incidence of treatment discontinuations or dosage reductions secondary to intolerable side effects...
January 18, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29348418/a-novel-modeling-in-mathematical-biology-for-classification-of-signal-peptides
#12
Asma Ehsan, Khalid Mahmood, Yaser Daanial Khan, Sher Afzal Khan, Kuo-Chen Chou
The molecular structure of macromolecules in living cells is ambiguous unless we classify them in a scientific manner. Signal peptides are of vital importance in determining the behavior of newly formed proteins towards their destined path in cellular and extracellular location in both eukaryotes and prokaryotes. In the present research work, a novel method is offered to foreknow the behavior of signal peptides and determine their cleavage site. The proposed model employs neural networks using isolated sets of prokaryote and eukaryote primary sequences...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348411/in-vivo-microscopic-photoacoustic-spectroscopy-for-non-invasive-glucose-monitoring-invulnerable-to-skin-secretion-products
#13
Joo Yong Sim, Chang-Geun Ahn, Eun-Ju Jeong, Bong Kyu Kim
Photoacoustic spectroscopy has been shown to be a promising tool for non-invasive blood glucose monitoring. However, the repeatability of such a method is susceptible to changes in skin condition, which is dependent on hand washing and drying due to the high absorption of infrared excitation light to the skin secretion products or water. In this paper, we present a method to meet the challenges of mid-infrared photoacoustic spectroscopy for non-invasive glucose monitoring. By obtaining the microscopic spatial information of skin during the spectroscopy measurement, the skin region where the infrared spectra is insensitive to skin condition can be locally selected, which enables reliable prediction of the blood glucose level from the photoacoustic spectroscopy signals...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348320/-18f-fdg-pet-ct-in-local-ablative-therapies-a-systematic-review
#14
Erik H J G Aarntzen, Linda Heijmen, Wim J G Oyen
Driven by the continuous improvement of the accuracy of cross-sectional imaging, image-guided minimally invasive local ablative therapies have received incremental interest over the past years. This study systematically reviews the currently available literature on [18F]FDG PET/CT to monitor the efficacy of these local ablative therapies. By including all local ablative treatment modalities, tumor types and organ sites, we provide a comprehensive overview of current status, identify general patterns across studies and provide recommendations for future studies and clinical practice...
January 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29348178/a-scoring-system-to-predict-the-elevation-of-mean-pulmonary-arterial-pressure-in-idiopathic-pulmonary-fibrosis
#15
Taiki Furukawa, Yasuhiro Kondoh, Hiroyuki Taniguchi, Mitsuaki Yagi, Toshiaki Matsuda, Tomoki Kimura, Kensuke Kataoka, Takeshi Johkoh, Masahiko Ando, Naozumi Hashimoto, Koji Sakamoto, Yoshinori Hasegawa
Elevated mean pulmonary arterial pressure (MPAP; ≥21 mmHg) is sometimes seen in patients with idiopathic pulmonary fibrosis (IPF) and has an adverse impact upon survival. Although early diagnosis is crucial, there is no established screening tool that uses a combination of noninvasive examinations.We retrospectively analysed IPF patients at initial evaluation from April 2007 to July 2015 and, using logistic regression analysis, created a screening tool to identify elevated MPAP. Internal validation was also assessed for external validity using a bootstrap method...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29348138/development-and-validation-of-outcome-prediction-models-for-aneurysmal-subarachnoid-haemorrhage-the-sahit-multinational-cohort-study
#16
Blessing N R Jaja, Gustavo Saposnik, Hester F Lingsma, Erin Macdonald, Kevin E Thorpe, Muhammed Mamdani, Ewout W Steyerberg, Andrew Molyneux, Airton Leonardo de Oliveira Manoel, Bawarjan Schatlo, Daniel Hanggi, David Hasan, George K C Wong, Nima Etminan, Hitoshi Fukuda, James Torner, Karl L Schaller, Jose I Suarez, Martin N Stienen, Mervyn D I Vergouwen, Gabriel J E Rinkel, Julian Spears, Michael D Cusimano, Michael Todd, Peter Le Roux, Peter Kirkpatrick, John Pickard, Walter M van den Bergh, Gordon Murray, S Claiborne Johnston, Sen Yamagata, Stephan Mayer, Tom A Schweizer, R Loch Macdonald
OBJECTIVE: To develop and validate a set of practical prediction tools that reliably estimate the outcome of subarachnoid haemorrhage from ruptured intracranial aneurysms (SAH). DESIGN: Cohort study with logistic regression analysis to combine predictors and treatment modality. SETTING: Subarachnoid Haemorrhage International Trialists' (SAHIT) data repository, including randomised clinical trials, prospective observational studies, and hospital registries...
January 18, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29347645/geometry-and-the-onset-of-rigidity-in-a-disordered-network
#17
Mathijs F J Vermeulen, Anwesha Bose, Cornelis Storm, Wouter G Ellenbroek
Disordered spring networks that are undercoordinated may abruptly rigidify when sufficient strain is applied. Since the deformation in response to applied strain does not change the generic quantifiers of network architecture, the number of nodes and the number of bonds between them, this rigidity transition must have a geometric origin. Naive, degree-of-freedom-based mechanical analyses such as the Maxwell-Calladine count or the pebble game algorithm overlook such geometric rigidity transitions and offer no means of predicting or characterizing them...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347620/suppression-of-crystalline-fluctuations-by-competing-structures-in-a-supercooled-liquid
#18
Pierre Ronceray, Peter Harrowell
We propose a geometrical characterization of amorphous liquid structures that suppress crystallization by competing locally with crystalline order. We introduce for this purpose the crystal affinity of a liquid, a simple measure of its propensity to accumulate local crystalline structures on cooling. This quantity is explicitly related to the high-temperature structural covariance between local fluctuations in crystal order and that of competing liquid structures: favoring a structure that, due to poor overlap properties, anticorrelates with crystalline order reduces the affinity of the liquid...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347566/macroscopic-phase-resetting-curves-for-spiking-neural-networks
#19
Grégory Dumont, G Bard Ermentrout, Boris Gutkin
The study of brain rhythms is an open-ended, and challenging, subject of interest in neuroscience. One of the best tools for the understanding of oscillations at the single neuron level is the phase-resetting curve (PRC). Synchronization in networks of neurons, effects of noise on the rhythms, effects of transient stimuli on the ongoing rhythmic activity, and many other features can be understood by the PRC. However, most macroscopic brain rhythms are generated by large populations of neurons, and so far it has been unclear how the PRC formulation can be extended to these more common rhythms...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347365/solution-x-ray-scattering-and-structure-formation-in-protein-dynamics
#20
Alexandr Nasedkin, Jan Davidsson, Antti J Niemi, Xubiao Peng
We propose a computationally effective approach that builds on Landau mean-field theory in combination with modern nonequilibrium statistical mechanics to model and interpret protein dynamics and structure formation in small- to wide-angle x-ray scattering (S/WAXS) experiments. We develop the methodology by analyzing experimental data in the case of Engrailed homeodomain protein as an example. We demonstrate how to interpret S/WAXS data qualitatively with a good precision and over an extended temperature range...
December 2017: Physical Review. E
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