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https://www.readbyqxmd.com/read/29793125/assessment-of-cam-morphology-of-the-hip-with-ultra-sound-imaging-by-physical-therapists-is-reliable-and-valid
#1
Liliane Mandema, Igor Tak, Brigitte Mooij, Ruud Groeneweg, Eric Bakker, Peter van Veldhoven
BACKGROUND: Femoroacetabular impingement syndrome is considered present when a combination of clinical symptoms, signs and morphological features of the hip co-exist. Imaging is increasingly popular in primary health care settings with physical therapists performing ultrasound (US). OBJECTIVE: The aim of this study was to assess the diagnostic accuracy and inter-rater reliability of ultrasound in determining presence of cam morphology. DESIGN: A concurrent validity and inter-rater reliability study...
April 14, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29793046/validation-of-the-revised-pam-score-in-patients-with-aml-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#2
Jan M Middeke, Frederike Kollinger, Henning Baldauf, Friedrich Stölzel, Martin Wermke, Malte von Bonin, Katja Sockel, Cornelia S Link, Raphael Teipel, Christoph Röllig, Christian Thiede, Uwe Platzbecker, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig
PURPOSE: Despite recent advances, allogeneic hematopoietic stem cell transplantation (alloHSCT) continues to be accompanied by a high rate of morbidity and mortality. Several scores have been developed to predict outcome after HSCT. The PAM score has been recently revised, and utilizes information on patient age, donor type, disease risk, cytomegalovirus (CMV) serostatus of patients and donors, and the forced expiratory volume in one second (FEV1). The aim of this study was to analyze the predictive power of the PAM score in an independent, large cohort of acute myeloid leukemia (AML) patients...
May 21, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29792988/towards-quantitative-prediction-of-the-performance-of-dry-powder-inhalers-by-multi-scale-simulations-and-experiments
#3
Duy Nguyen, Johan Remmelgas, Ingela Niklasson Björn, Berend van Wachem, Kyrre Thalberg
This work demonstrates the use of multi-scale simulations coupled with experiments to build a quantitative prediction tool for the performance of adhesive mixtures in a dry powder inhaler (DPI). Using discrete element model (DEM), the behaviour of fine-carrier particle assemblies upon different mechanisms encountered during dose entrainment and dispersion can be described at the individual particle level. Combining these results with computational fluid dynamics (CFD) simulations, the complete dosing event from a DPI can be captured and key performance measures can be extracted...
May 21, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29792762/genetic-profiling-in-acute-myeloid-leukemia-a-path-to-predicting-treatment-outcome
#4
Giuseppe Visani, Federica Loscocco, Alessandro Isidori, Pier Paolo Piccaluga
Despite substantial progresses in acute myeloid leukemia (AML) diagnosis and treatment, at least half of patient will eventually die for the disease. In the last decades, the use of genetic and genomic approaches allowed the identification of patients with higher risk of recurrence after and/or resistance to CHT. However, though many novel drugs have been proposed and tested, only little clinical improvements have been made concerning the treatment of the so called 'high risk' patients. Areas covered: In this article, the authors, based on their own experience and the most updated literature, review the basic knowledge of AML prognostication and treatment prediction developed throughout genetic and genomic profiling, and focus on the use of gene expression profiling as a promising predictive tool...
May 24, 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29792506/testing-the-validity-of-criminal-risk-assessment-tools-in-sexually-abusive-youth
#5
Steffen Barra, Cornelia Bessler, Markus A Landolt, Marcel Aebi
Although accurate risk appraisals are mandatory to provide effective treatment to juveniles who have sexually offended (JSOs), the current knowledge on the validity of risk assessment instruments for JSOs is inconclusive. We compared the predictive validities of the Juvenile Sex Offender Assessment Protocol II (J-SOAP II), the Estimate of Risk of Adolescent Sexual Offense Recidivism (ERASOR), and the Violence Risk Appraisal Guide-Revised (VRAG-R) scores concerning sexual, nonsexual-violent, and general criminal recidivism (based on both official and nonregistered reoffenses) in a consecutive sample of 597 male JSOs (Mage = 14...
May 24, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29792335/synthesis-of-novel-thymol-derivatives-against-mrsa-and-esbl-producing-pathogenic-bacteria
#6
Shasank S Swain, Sudhir K Paidesetty, Rabindra N Padhy
Twelve substituted aryl-azo-thymol derivatives (4a to 4 l) were synthesized and characterized by several spectral techniques such as, FTIR, UV-vis, proton NMR, Mass spectrometry and elemental analysis. Antimicrobial activities were evaluated by agar-well diffusion method against isolated MRSA, ESBL-producing pathogenic bacteria and antifungal resistant fungi, in vitro. In addition, drug likeness properties of derivatives were assessed through bioinformatic tools such as, PASS prediction, molecular docking and Lipinski rules of five, along with determination of toxic nature and LD50 values...
May 24, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29792117/the-rockwood-classification-in-acute-acromioclavicular-joint-injury-does-not-correlate-with-symptoms
#7
J Granville-Chapman, E Torrance, A Rashid, L Funk
PURPOSE: Rockwood classified acromioclavicular (AC) joint injuries by displacement of the joint on radiographs. This classification has driven the management dogma of acute AC dislocation. The correlation between Rockwood grade and symptoms has not been described in acute injury. This study assesses that relationship. METHODS: This series included 77 patients with acute AC joint injury (<6 weeks), treated between 2006 and 2015. Objective and patient-reported measures enabled correlation between clinical measures and Rockwood grade...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29792115/using-machine-learning-to-advance-personality-assessment-and-theory
#8
Wiebke Bleidorn, Christopher James Hopwood
Machine learning has led to important advances in society. One of the most exciting applications of machine learning in psychological science has been the development of assessment tools that can powerfully predict human behavior and personality traits. Thus far, machine learning approaches to personality assessment have focused on the associations between social media and other digital records with established personality measures. The goal of this article is to expand the potential of machine learning approaches to personality assessment by embedding it in a more comprehensive construct validation framework...
May 1, 2018: Personality and Social Psychology Review
https://www.readbyqxmd.com/read/29792051/predicting-suicide-attempts-and-suicide-deaths-following-outpatient-visits-using-electronic-health-records
#9
Gregory E Simon, Eric Johnson, Jean M Lawrence, Rebecca C Rossom, Brian Ahmedani, Frances L Lynch, Arne Beck, Beth Waitzfelder, Rebecca Ziebell, Robert B Penfold, Susan M Shortreed
OBJECTIVE: The authors sought to develop and validate models using electronic health records to predict suicide attempt and suicide death following an outpatient visit. METHOD: Across seven health systems, 2,960,929 patients age 13 or older (mean age, 46 years; 62% female) made 10,275,853 specialty mental health visits and 9,685,206 primary care visits with mental health diagnoses between Jan. 1, 2009, and June 30, 2015. Health system records and state death certificate data identified suicide attempts (N=24,133) and suicide deaths (N=1,240) over 90 days following each visit...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29791526/geomorphology-based-unit-hydrograph-models-for-flood-risk-management-case-study-in-brazilian-watersheds-with-contrasting-physiographic-characteristics
#10
Samuel Beskow, Gabriela S Nunes, Carlos R DE Mello, Tamara L Caldeira, Lloyd D Norton, Alice A Steinmetz, Marcelle M Vargas, Léo F Ávila
Heavy rainfall in conjunction with an increase in population and intensification of agricultural activities have resulted in countless problems related to flooding in watersheds. Among the techniques available for direct surface runoff (DSR) modeling and flood risk management are the Unit Hydrograph (UH) and Instantaneous Unit Hydrograph (IUH). This study focuses on the evaluation of predictive capability of two conceptual IUH models (Nash and Clark), considering their original (NIUH and CIUH) and geomorphological approaches (NIUHGEO and CIUHGEO), and their advantages over two traditional synthetics UH models - Triangular (TUH) and Dimensionless (DUH), to estimate DSR hydrographs taking as reference two Brazilian watersheds with contrasting geomorphological and climatic characteristics...
May 21, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29791467/scan-patterns-during-scene-viewing-predict-individual-differences-in-clinical-traits-in-a-normative-sample
#11
Taylor R Hayes, John M Henderson
The relationship between viewer individual differences and gaze control has been largely neglected in the scene perception literature. Recently we have shown a robust association between individual differences in viewer cognitive capacity and scan patterns during scene viewing. These findings suggest other viewer individual differences may also be associated with scene gaze control. Here we expand our findings to quantify the relationship between individual differences in clinical traits and scene viewing behavior in a normative sample...
2018: PloS One
https://www.readbyqxmd.com/read/29791401/investigation-of-index-change-in-compression-molding-of-as-40-se-50-s-10-chalcogenide-glass
#12
Lin Zhang, Wenchen Zhou, Neil J Naples, Allen Y Yi
Chalcogenide glasses are emerging as alternative materials for low-cost and high-volume glass molding processes for infrared optics. In precision glass molding, it is well documented that the refractive index variation in the molded elements can lead to substantial amounts of aberrations. The variation has such a significant effect that the optical designs with molded lenses need to be carefully considered and compensated for index variation to achieve targeted optical performance. This research is aimed to evaluate the refractive index change of a chalcogenide glass during the molding process by both finite element method-based simulation and optical experiment...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791333/modeling-of-microjoule-and-millijoule-energy-lidars-with-pmt-sipm-apd-detectors-a-sensitivity-analysis
#13
Ravil Agishev
This paper demonstrates a renewed concept and applications of the generalized methodology for atmospheric light detection and ranging (LIDAR) capability prediction as a continuation of a series of our previous works, where the dimensionless parameterization appeared as a tool for comparing systems of a different scale, design, and applications. The modernized concept applied to microscale and milliscale LIDARs with relatively new silicon photomultiplier detectors and traditional photomultiplier tube and avalanche photodiode detectors allowed prediction of the remote sensing instruments' performance and limitations...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791163/on-the-relationship-between-excited-state-lifetime-and-isomerization-quantum-yield-in-animal-rhodopsins-beyond-the-one-dimensional-landau-zener-model
#14
Mohsen M T El-Tahawy, Artur Nenov, Oliver Weingart, Massimo Olivucci, Marco Garavelli
We show that the speed of the chromophore photoisomerization of animal rhodopsins is not a relevant control knob for their light sensitivity. This result is at odd with the momentum-driven tunnelling rationale (i.e., assuming a one-dimensional Landau-Zener model for the decay: Zener, C. "Non-Adiabatic Crossing of Energy Levels", Proceedings of the Royal Society of London. Series A 1932, 137 (833), 696-702) holding that a faster nuclear motion through the conical intersection translates into a higher quantum yield and, thus, light sensitivity...
May 23, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29790979/petrosal-meningiomas-factors-affecting-outcome-and-the-role-of-intraoperative-multimodal-assistance-to-microsurgery
#15
Francesco Tomasello, Filippo Flavio Angileri, Alfredo Conti, Antonino Scibilia, Salvatore Cardali, Domenico La Torre, Antonino Germanò
BACKGROUND: Petrous meningiomas (PMs) represent a subset of posterior fossa tumors accounting for ∼8% of all intracranial meningiomas. Surgical treatment of PMs is challenging because of their relationships with vital neurovascular structures of the cerebellopontine angle. OBJECTIVE: To investigate independent pre- and intraoperative predictors of PM surgery outcome. METHODS: We reviewed the surgical and outcome data of patients who underwent microsurgical resection of PMs from 1997 to 2016...
May 22, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29790974/crisprcasfinder-an-update-of-crisrfinder-includes-a-portable-version-enhanced-performance-and-integrates-search-for-cas-proteins
#16
David Couvin, Aude Bernheim, Claire Toffano-Nioche, Marie Touchon, Juraj Michalik, Bertrand Néron, Eduardo P C Rocha, Gilles Vergnaud, Daniel Gautheret, Christine Pourcel
CRISPR (clustered regularly interspaced short palindromic repeats) arrays and their associated (Cas) proteins confer bacteria and archaea adaptive immunity against exogenous mobile genetic elements, such as phages or plasmids. CRISPRCasFinder allows the identification of both CRISPR arrays and Cas proteins. The program includes: (i) an improved CRISPR array detection tool facilitating expert validation based on a rating system, (ii) prediction of CRISPR orientation and (iii) a Cas protein detection and typing tool updated to match the latest classification scheme of these systems...
May 22, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29790453/thyroid-hypoplasia-in-congenital-hypothyroidism-associated-with-thyroid-peroxidase-mutations
#17
Athanasia Stoupa, Rim Chaabane, Manelle Guériouz, Catherine Raynaud-Ravni, Patrick Nitschke, Christine Bole-Feyset, Mouna Mnif, Leila Ammar Keskes, Mongia Hachicha, Neila Belguith, Michel Polak, Aurore Carré
CONTEXT: Primary congenital hypothyroidism (CH) affects about 1:3000 newborns worldwide and is mainly caused by defects in thyroid gland development (thyroid dysgenesis, TD) or hormone synthesis. A genetic cause is identified in less than 10% of TD patients. Our aim was to identify novel candidate genes in patients with TD using next-generation sequencing tools. PATIENT FINDINGS: We used whole exome sequencing (WES) to study two families, a consanguineous Tunisian family (one child with severe thyroid hypoplasia) and a French family (two newborn siblings, with a thyroid in situ that was not enlarged on ultrasound at diagnosis)...
May 23, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29790335/accurate-electron-nucleus-distances-from-paramagnetic-relaxation-enhancements
#18
Henry W Orton, Gottfried Otting
Measurements of paramagnetic relaxation enhancements (PRE) in 1H-NMR spectra are an important tool to obtain long-range distance information in proteins, but quantitative interpretation is easily compromised by non-specific intermolecular PREs. Here we show that PREs generated by lanthanides with anisotropic magnetic susceptibilities offer a route to accurate calibration-free distance measurements. As these lanthanides change 1H chemical shifts due to pseudocontact shifts, the relaxation rates in the paramagnetic and diamagnetic state can be measured with a single sample that simultaneously contains the protein labeled with a paramagnetic and a diamagnetic lanthanide ion...
May 23, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29790236/forecasting-zoonotic-cutaneous-leishmaniasis-using-meteorological-factors-in-eastern-fars-province-iran-a-sarima-analysis
#19
Hamid Reza Tohidinik, Mehdi Mohebali, Mohammad Ali Mansournia, Sharareh R Niakan Kalhori, Mohsen Ali-Akbarpour, Kamran Yazdani
OBJECTIVES: To predict the occurrence of zoonotic cutaneous leishmaniasis (ZCL) and evaluate the effect of climatic variables on disease incidence in the east of Fars province, Iran using the Seasonal Autoregressive Integrated Moving Average (SARIMA) model. METHODS: The Box-Jenkins approach was applied to fit the SARIMA model for ZCL incidence from 2004 to 2015. Then the model was used to predict the number of ZCL cases for the year 2016. Finally, we assessed the relation of meteorological variables (rainfall, rainy days, temperature, hours of sunshine and relative humidity) with ZCL incidence...
May 22, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29790049/a-simple-approach-to-estimate-daily-loads-of-total-refractory-and-labile-organic-carbon-from-their-seasonal-loads-in-a-watershed
#20
Ying Ouyang, Johnny M Grace, Wayne C Zipperer, Jeff Hatten, Janet Dewey
Loads of naturally occurring total organic carbons (TOC), refractory organic carbon (ROC), and labile organic carbon (LOC) in streams control the availability of nutrients and the solubility and toxicity of contaminants and affect biological activities through absorption of light and complex metals with production of carcinogenic compounds. Although computer models have become increasingly popular in understanding and management of TOC, ROC, and LOC loads in streams, the usefulness of these models hinges on the availability of daily data for model calibration and validation...
May 22, 2018: Environmental Science and Pollution Research International
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