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https://www.readbyqxmd.com/read/28783582/cytotoxic-effects-of-fritillaria-imperialis-l-extracts-on-human-liver-cancer-cells-breast-cancer-cells-and-fibroblast-like-cells
#1
Ozra Zarei, Mohammad Mehdi Yaghoobi
In this study, we evaluated the cytotoxic effects of Fritillaria imperialis L. aqueous and ethanolic extracts on human liver cancer cells (LCL-PI 11), breast adenocarcinoma cells (MCF-7) and fibroblast-like cells (HSkMC). MTT, BrdU and TUNEL assays were used to detect cytotoxicity, proliferation rate and apoptotic death. Following 48h, the IC50 values for LCL-PI11 and MCF-7 cells were 4.2 and 3.9μg/mL of aqueous extract, and 1.7 and 1.3μg/mL of ethanolic extract, respectively, which was comparable to that of 5-FU...
August 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28782837/in-situ-force-in-the-anterior-cruciate-ligament-the-lateral-collateral-ligament-and-the-anterolateral-capsule-complex-during-a-simulated-pivot-shift-test
#2
Kevin M Bell, Ata A Rahnemai-Azar, Sebastian Irarrazaval, Daniel Guenther, Freddie H Fu, Volker Musahl, Richard E Debski
The role of the anterolateral capsule complex in knee rotatory stability remains controversial. Therefore, the objective of this study was to determine the in-situ forces in the anterior cruciate ligament (ACL), the anterolateral capsule, the lateral collateral ligament (LCL), and the forces transmitted between each region of the anterolateral capsule in response to a simulated pivot shift test. A robotic testing system applied a simulated pivot shift test continuously from full extension to 90(o) of flexion to intact cadaveric knees (n = 7)...
August 7, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28770380/sex-steroids-modulate-morphological-and-functional-features-of-the-bovine-oviduct
#3
Angela Maria Gonella-Diaza, Fernando Silveira Mesquita, Kauê Ribeiro da Silva, Júlio Cesar de Carvalho Balieiro, Nilton Pedro Dos Santos, Guilherme Pugliesi, Ricardo de Francisco Strefezzi, Mario Binelli
In cattle, the oviduct plays a major role in the reproductive process; however, molecular control of oviduct receptivity to the embryo is poorly understood. A model for receptivity based on size of the pre-ovulatory follicle (POF) was used to compare oviductal morphology, cellular proliferation, and candidate transcript abundance. Growth of the POF of Nelore (Bos indicus) cows was manipulated to produce two groups: a large POF-large corpus luteum (CL) group (LF-LCL; greater receptivity) and a small POF-small CL group (SF-SCL)...
August 2, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28736497/differences-between-the-genomes-of-lymphoblastoid-cell-lines-and-blood-derived-samples
#4
Lena M Joesch-Cohen, Gustavo Glusman
Lymphoblastoid cell lines (LCLs) represent a convenient research tool for expanding the amount of biologic material available from an individual. LCLs are commonly used as reference materials, most notably from the Genome in a Bottle Consortium. However, the question remains how faithfully LCL-derived genome assemblies represent the germline genome of the donor individual as compared to the genome assemblies derived from peripheral blood mononuclear cells. We present an in-depth comparison of a large collection of LCL- and peripheral blood mononuclear cell-derived genomes in terms of distributions of coverage and copy number alterations...
2017: Advances in Genomics and Genetics
https://www.readbyqxmd.com/read/28734719/coronoid-reconstruction-using-osteochondral-grafts-a-biomechanical-study
#5
Enrico Bellato, Youngbok Kim, James S Fitzsimmons, Lawrence J Berglund, Alexander W Hooke, Daniel R Bachman, Shawn W O'Driscoll
HYPOTHESIS: The purposes of this study were to test the hypothesis that coronoid deficiency in the setting of posteromedial rotatory instability (PMRI) must be reconstructed to restore articular contact pressures to normal and to compare 3 different osteochondral grafts for this purpose. METHODS: After creation of a anteromedial fracture, six cadaveric elbows were tested under gravity varus stress using a custom-made machine designed to simulate muscle loads and to passively flex the elbow...
July 19, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28712122/clinical-features-and-treatment-response-of-cutaneous-leishmaniasis-in-north-west-ethiopia
#6
Helina Fikre, Rezika Mohammed, Saba Atinafu, Johan van Griensven, Ermias Diro
OBJECTIVE: Cutaneous leishmaniasis (CL) receives far less attention than visceral leishmaniasis. Nevertheless, CL is predominantly caused by a unique species in Ethiopia (L aethiopica), which is known to cause severe forms such as diffuse (DCL) and mucocutaneous leishmaniasis (MCL). We report on the number and type of CL cases diagnosed, the clinical features, the treatments and treatment outcomes in North-West Ethiopia. METHODS: This is a retrospective chart record analysis of CL patients treated at the Leishmania Research and Treatment Center (LRTC) of the University of Gondar, Ethiopia...
July 16, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28707080/reproductive-outcomes-of-anestrous-goats-supplemented-with-spineless-opuntia-megacantha-salm-dyck-protein-enriched-cladodes-and-exposed-to-the-male-effect
#7
Cesar A Meza-Herrera, Omag Cano-Villegas, Arnoldo Flores-Hernandez, Francisco G Veliz-Deras, Guadalupe Calderon-Leyva, Juan M Guillen-Muñoz, Cristina García de la Peña, Cesar A Rosales-Nieto, Ulises Macias-Cruz, Leonel Avendaño-Reyes
The possible influence of the "male effect" upon reproductive outcomes of adult anestrous goats under marginal rangeland conditions and supplemented with protein-enriched Opuntia megacantha Salm-Dyck was evaluated. Reproductive variables included: estrus percentage (EST, %), estrus latency (ESL, hours), ovulation percentage (OP, %), ovulation rate (OR, units), average largest follicle at ovulation (LFO, mm), largest corpus luteum (LCL, mm), embryo number (EBN, units), and embryo implantation percentage (EIP, %)...
July 13, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28698915/surgical-treatment-of-stage-ii-posterior-tibialis-tendon-dysfunction-ten-year-clinical-and-radiographic-results
#8
Alberto Ruffilli, Francesco Traina, Sandro Giannini, Roberto Buda, Fabrizio Perna, Cesare Faldini
INTRODUCTION: Grade II chronic tibialis posterior tendon dysfunction (PTTD) poses a reconstructive challenge to the orthopaedic surgeon. Aim of this retrospective study is to report the clinical and radiographical results of a case series of 63 patients (102 ft) affected by grade II PTTD who underwent tailored surgical treatment at 10-year mean follow-up. MATERIALS AND METHODS: Sixty-three patients (102 ft) were available for clinical and radiological evaluation and were retrospectively reviewed at a mean follow-up of 125...
July 11, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28698614/spatial-patterns-of-wet-season-precipitation-vertical-gradients-on-the-tibetan-plateau-and-the-surroundings
#9
Lan Cuo, Yongxin Zhang
The Tibetan Plateau and the surrounding (TPS) with its vast land mass and high elevation affects regional climate and weather. The TPS is also the headwater of 9 major Asian rivers that provide fresh water for 1.65 billion people and many ecosystems, with wet season (May-September) precipitation being the critical component of the fresh water. Using station observations, ERA-Interim and MERRA2 reanalysis, we find that wet season precipitation displays vertical gradients (i.e., changes with elevation) that vary within the region on the TPS...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28696813/liposomal-prednisolone-phosphate-potentiates-the-antitumor-activity-of-liposomal-5-fluorouracil-in-c26-murine-colon-carcinoma-in-vivo
#10
Laura Patras, Bianca Sylvester, Lavinia Luput, Alina Sesarman, Emilia Licarete, Alina Porfire, Dana Muntean, Denise Minerva Drotar, Alexandra Doina Rusu, Andras-Laszlo Nagy, Cornel Catoi, Ioan Tomuta, Laurian Vlase, Manuela Banciu, Marcela Achim
The antitumor efficacy of 5-fluorouracil (5-FU) in advanced colorectal cancer (CRC) is hindered not only by the low therapeutic index, but also by tumor cell resistance to this cytotoxic drug. Therefore, to enhance the 5-FU antitumor activity, the present research employed a novel tumor-targeted therapy based on the co-administration of 5-FU encapsulated in long-circulating liposomes (LCL-5-FU) together with liposomal prednisolone phosphate (LCL-PLP), a formulation with known anti-angiogenic actions on C26 murine colon carcinoma cells...
July 11, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28696495/robotic-arm-assisted-total-knee-arthroplasty-demonstrated-soft-tissue-protection
#11
Anton Khlopas, Morad Chughtai, Emily L Hampp, Laura Y Scholl, Michael Prieto, Ta-Cheng Chang, Abdullah Abbasi, Manoshi Bhowmik-Stoker, Jason Otto, David J Jacofsky, Michael A Mont
INTRODUCTION: While total knee arthroplasty (TKA) procedures have demonstrated clinical success, occasionally intraoperative complications can occur. Collateral or posterior cruciate ligament injury, instability, extensor mechanism disruption, and tibiofemoral or patellofemoral dislocation are among a few of the intraoperatively driven adverse events prevalently ranked by The Knee Society. Robotic-arm assisted TKA (RATKA) provides a surgeon the ability to three-dimensionally plan a TKA and use intraoperative visual, auditory, and tactile feedback to ensure that only the desired bone cuts are made...
July 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28694700/role-of-sirt1-pgc-1%C3%AE-in-mitochondrial-oxidative-stress-in-autistic-spectrum-disorder
#12
Xiaosong Bu, De Wu, Xiaomei Lu, Li Yang, Xiaoyan Xu, Juan Wang, Jiulai Tang
Autistic spectrum disorder (ASD) is a neurodevelopmental disorder and has a high prevalence in children. Recently, mitochondrial oxidative stress has been proposed to be associated with ASD. Besides, SIRT1/PGC-1α signaling plays an important role in combating oxidative stress. In this study, we sought to determine the role of SIRT1/PGC-1α signaling in the ASD lymphoblastoid cell lines (LCLs). In this study, the mRNA and protein expressions of SIRT1/PGC-1α axis genes were assessed in 35 children with ASD and 35 healthy controls (matched for age, gender, and IQ)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28689821/role-of-the-lateral-collateral-ligament-in-posteromedial-rotatory-instability-of-the-elbow
#13
Enrico Bellato, Youngbok Kim, James S Fitzsimmons, Alexander W Hooke, Lawrence J Berglund, Daniel R Bachman, Shawn W O'Driscoll
BACKGROUND: Posteromedial rotatory instability (PMRI) of the elbow consists of an anteromedial coronoid fracture with lateral collateral ligament (LCL) and posterior bundle of the medial collateral ligament (PMCL) tears. We hypothesized that the LCL tear is required for elbow subluxation/joint incongruity and that an elbow affected by an anteromedial subtype 2 coronoid fracture and a PMCL tear exhibits contact pressures different from both an intact elbow and an elbow affected by PMRI...
September 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28685784/%C3%AE-pyridylenolate-zinc-catalysts-for-the-ring-opening-homo-and-copolymerization-of-%C3%AE%C2%B5-caprolactone-and-lactides
#14
Jianliang Bai, Xia Xiao, Yue Zhang, Jianbin Chao, Xia Chen
A family of zinc β-pyridylenolates with varying α,β-substituents has been synthesized. A direct reaction of β-pyridyl ketone ligands with ZnEt2 in toluene afforded dimeric [LZnEt]2 (L = (2-C5H4N)-C(R(1))[double bond, length as m-dash]C(R(2))-O-). X-ray structural data revealed that all the [LZnEt]2 complexes exist as μ-O-bridged dimers in the solid state, although they adopt a different geometry. Each of the [LZnEt]2 complexes is a highly active catalyst for the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) and racemic lactide (rac-LA), respectively...
August 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28667285/oxidative-stress-challenge-uncovers-trichloroacetaldehyde-hydrate-induced-mitoplasticity-in-autistic-and-control-lymphoblastoid-cell-lines
#15
Richard Eugene Frye, Shannon Rose, Rebecca Wynne, Sirish C Bennuri, Sarah Blossom, Kathleen M Gilbert, Lynne Heilbrun, Raymond F Palmer
Mitoplasticity occurs when mitochondria adapt to tolerate stressors. Previously we hypothesized that a subset of lymphoblastoid cell lines (LCLs) from children with autistic disorder (AD) show mitoplasticity (AD-A), presumably due to previous environmental exposures; another subset of AD LCLs demonstrated normal mitochondrial activity (AD-N). To better understand mitoplasticity in the AD-A LCLs we examined changes in mitochondrial function using the Seahorse XF96 analyzer in AD and Control LCLs after exposure to trichloroacetaldehyde hydrate (TCAH), an in vivo metabolite of the environmental toxicant and common environmental pollutant trichloroethylene...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28666266/combination-of-betulinic-acid-and-chidamide-synergistically-inhibits-epstein-barr-virus-replication-through-over-generation-of-reactive-oxygen-species
#16
Haibing Yu, Hongyu Zhang, Zhigang Chu, Qiongfang Ruan, Xueru Chen, Danli Kong, Xiaodong Huang, Huawen Li, Huanwen Tang, Hongjin Wu, Yifei Wang, Weiguo Xie, Yuanling Ding, Paul Yao
Epstein-Barr virus (EBV) has widely infected more than 90% of human populations. Currently, there is no efficient way to remove the virus because the EBV carriers are usually in a latent stage that allows them to escape the immune system and common antiviral drugs. In the effort to develop an efficient strategy for the removal of the EBV virus, we have shown that betulinic acid (BA) slightly suppresses EBV replication through SOD2 suppression with subsequent reactive oxygen species (ROS) generation and DNA damage in EBV-transformed LCL (lymphoblastoid cell line) cells...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28662974/u-s-cannabis-legalization-and-use-of-vaping-and-edible-products-among-youth
#17
Jacob T Borodovsky, Dustin C Lee, Benjamin S Crosier, Joy L Gabrielli, James D Sargent, Alan J Budney
BACKGROUND: Alternative methods for consuming cannabis (e.g., vaping and edibles) have become more popular in the wake of U.S. cannabis legalization. Specific provisions of legal cannabis laws (LCL) (e.g., dispensary regulations) may impact the likelihood that youth will use alternative methods and the age at which they first try the method - potentially magnifying or mitigating the developmental harms of cannabis use. METHODS: This study examined associations between LCL provisions and how youth consume cannabis...
August 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28656567/varus-valgus-instability-in-the-anterior-cruciate-ligament-deficient-knee-effect-of-posterior-tibial-load
#18
Tomoki Ohori, Tatsuo Mae, Konsei Shino, Yuta Tachibana, Hiromichi Fujie, Hideki Yoshikawa, Ken Nakata
BACKGROUND: Anterior cruciate ligament (ACL) injury is often accompanied with medial collateral ligament (MCL) injury. Assessment of varus-valgus (V-V) instability in the ACL-deficient knee is crucial for the management of the concomitant ACL-collateral ligaments injury. We evaluated the V-V laxity and investigated the effect of additional posterior tibial load on the laxity in the ACL-deficient knee. Our hypothesis was that the V-V laxity in the ACL-deficient knee was greater than that in the intact knee and attenuated by additional posterior tibial load...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28654678/genetic-factors-affecting-ebv-copy-number-in-lymphoblastoid-cell-lines-derived-from-the-1000-genome-project-samples
#19
Rajendra Mandage, Marco Telford, Juan Antonio Rodríguez, Xavier Farré, Hafid Layouni, Urko M Marigorta, Caitlin Cundiff, Jose Maria Heredia-Genestar, Arcadi Navarro, Gabriel Santpere
Epstein-Barr virus (EBV), human herpes virus 4, has been classically associated with infectious mononucleosis, multiple sclerosis and several types of cancers. Many of these diseases show marked geographical differences in prevalence, which points to underlying genetic and/or environmental factors. Those factors may include a different susceptibility to EBV infection and viral copy number among human populations. Since EBV is commonly used to transform B-cells into lymphoblastoid cell lines (LCLs) we hypothesize that differences in EBV copy number among individual LCLs may reflect differential susceptibility to EBV infection...
2017: PloS One
https://www.readbyqxmd.com/read/28630707/evidence-of-endometrial-amino-acid-metabolism-and-transport-modulation-by-peri-ovulatory-endocrine-profiles-driving-uterine-receptivity
#20
Moana Rodrigues França, Maressa Izabel Santos da Silva, Guilherme Pugliesi, Veerle Van Hoeck, Mario Binelli
BACKGROUND: In beef cattle, changes in the periovulatory endocrine milieu are associated with fertility and conceptus growth. A large preovulatory follicle (POF) and the resulting elevated concentrations of progesterone (P4) during diestrus positively affect pregnancy rates. Amino acids (AA) are important components of maternally derived secretions that are crucial for embryonic survival before implantation. The hypothesis is that the size of the POF and the concentration of P4 in early diestrus modulate the endometrial abundance of SLC transcripts related to AA transport and metabolism and subsequently impact luminal concentrations of AA...
2017: Journal of Animal Science and Biotechnology
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