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https://www.readbyqxmd.com/read/28497049/biomechanical-analysis-of-cuboid-osteotomy-lateral-column-lengthening-for-stage-ii-b-adult-acquired-flatfoot-deformity-a-cadaveric-study
#1
Haichao Zhou, Haoyang Ren, Chunguang Li, Jiang Xia, Guangrong Yu, Yunfeng Yang
Purpose. To investigate the effect of cuboid osteotomy lateral column lengthening (LCL) for the correction of stage II B adult-acquired flatfoot deformity in cadaver. Methods. Six cadaver specimens were loaded to 350 N. Flatfoot models were established and each was evaluated radiographically and pedobarographically in the following conditions: (1) intact foot, (2) flatfoot, and (3) cuboid osteotomy LCL (2, 3, 4, and 5 mm). Results. Compared with the flatfoot model, the LCLs showed significant correction of talonavicular coverage on anteroposterior radiographs and talus-first metatarsal angle on both anteroposterior and lateral radiographs (p < ...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28497021/understanding-rare-adverse-sequelae-of-breast-implants-anaplastic-large-cell-lymphoma-late-seromas-and-double-capsules
#2
REVIEW
Mark W Clemens, Maurizio Bruno Nava, Nicola Rocco, Roberto N Miranda
Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a distinct type of T-cell lymphoma arising around breast implants. The United States FDA recently updated the 2011 safety communication, warning that women with breast implants may have a very low risk of developing ALCL adjacent to a breast implant. According to the World Health Organization, BI-LCL is not a breast cancer or cancer of the breast tissue; it is a lymphoma, a cancer of immune cells. BI-ALCL is highly curable in the majority of patients...
April 2017: Gland Surgery
https://www.readbyqxmd.com/read/28494239/crispr-cas9-screens-reveal-epstein-barr-virus-transformed-b-cell-host-dependency-factors
#3
Yijie Ma, Michael J Walsh, Katharina Bernhardt, Camille W Ashbaugh, Stephen J Trudeau, Isabelle Y Ashbaugh, Sizun Jiang, Chang Jiang, Bo Zhao, David E Root, John G Doench, Benjamin E Gewurz
Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (BL) and immunosuppression-related lymphomas. These B cell malignancies arise by distinct transformation pathways and have divergent viral and host expression programs. To identify host dependency factors resulting from these EBV+, B cell-transformed cell states, we performed parallel genome-wide CRISPR/Cas9 loss-of-function screens in BL and lymphoblastoid cell lines (LCLs). These highlighted 57 BL and 87 LCL genes uniquely important for their growth and survival...
May 10, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28475033/differentially-expressed-genes-during-spontaneous-lytic-switch-of-marek-s-disease-virus-in-lymphoblastoid-cell-lines-determined-by-global-gene-expression-profiling
#4
William N Mwangi, Deepali Vasoya, Lydia B Kgosana, Mick Watson, Venugopal Nair
Marek's disease virus (MDV), an alphaherpesvirus of poultry, causes Marek's disease and is characterized by visceral CD4+TCRαβ+ T-cell lymphomas in susceptible hosts. Immortal cell lines harbouring the viral genome have been generated from ex vivo cultures of MD tumours. As readily available sources of large numbers of cells, MDV-transformed lymphoblastoid cell lines (LCLs) are extremely valuable for studies of virus-host interaction. While the viral genome in most cells is held in a latent state, minor populations of cells display spontaneous reactivation identifiable by the expression of lytic viral genes...
April 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28461924/lateral-collateral-ligament-injuries-of-the-elbow-chronic-posterolateral-rotatory-instability-plri
#5
REVIEW
Megan Conti Mica, Pieter Caekebeke, Roger van Riet
Chronic posterolateral rotatory instability (PLRI) is the most common form of chronic elbow instability.PLRI usually occurs from a fall on the outstretched hand. On impact, the radial head and ulna rotate externally coupled with valgus displacement of the forearm. This leads to posterior displacement of the radial head relative to the capitellum, thus causing disruption of some or all of the lateral-sided stabilisers.PLRI is mainly a clinical diagnosis with a history of instability, clicking and lateral-sided pain, with a positive clinical examination including the pivot-shift test, push-up, chair and tabletop test...
December 2016: EFORT Open Rev
https://www.readbyqxmd.com/read/28451605/the-impact-of-osseous-malalignment-and-realignment-procedures-in-knee-ligament-surgery-a-systematic-review-of-the-clinical-evidence
#6
REVIEW
Thomas Tischer, Jochen Paul, Dietrich Pape, Michael T Hirschmann, Andreas B Imhoff, Stefan Hinterwimmer, Matthias J Feucht
BACKGROUND: Failure rates of knee ligament surgery may be high, and the impact of osseous alignment on surgical outcome remains controversial. Basic science studies have demonstrated that osseous malalignment can negatively affect ligament strain and that realignment procedures may improve knee joint stability. HYPOTHESIS/PURPOSE: The purpose of this review was to summarize the clinical evidence concerning the impact of osseous malalignment and realignment procedures in knee ligament surgery...
March 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28442063/peri-ovulatory-endocrine-regulation-of-the-prostanoid-pathways-in-the-bovine-uterus-at-early-dioestrus
#7
Milena Lopes Oliveira, Fabio Luiz D'Alexandri, Guilherme Pugliesi, Veerle Van Hoeck, Fernando Silveira Mesquita, Claudia M B Membrive, João Alberto Negrão, Craig E Wheelock, Mario Binelli
We hypothesised that different endocrine profiles associated with pre-ovulatory follicle (POF) size would impact on uterine prostanoid pathways and thereby modulate the histotroph composition. Beef cows (n=15 per group) were hormonally manipulated to have small (SF-SCL group) or large (LF-LCL group) pre-ovulatory follicles (POF) and corpora lutea (CL). Seven days after induction of ovulation, animals were slaughtered and uterine tissues and flushings were collected for quantification of prostanoids. The POF and CL size and the circulating progesterone concentrations at Day 7 were greater (P<0...
March 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28431191/timing-for-the-introduction-of-cycled-light-for-extremely-preterm-infants-a-randomized-controlled-trial
#8
Debra H Brandon, Susan G Silva, Jinhee Park, William Malcolm, Heba Kamhawy, Diane Holditch-Davis
Day-night cycled light improves health outcomes in preterm infants, yet the best time to institute cycled light is unclear. The hypothesis of this study was that extremely preterm infants receiving early cycled light would have better health and developmental outcomes than infants receiving late cycled light. Infants born at ≤28 weeks gestation were randomly assigned to early cycled light (ECL) starting at 28 weeks postmenstrual age [PMA] or late cycled light (LCL), starting at 36 weeks PMA. Daylight was 200-600 lux and night was 5-30 lux...
April 21, 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/28419804/simultaneous-reconstruction-of-the-medial-and-lateral-collateral-ligaments-for-chronic-combined-ligament-injuries-of-the-ankle
#9
Toshito Yasuda, Hiroaki Shima, Katsunori Mori, Seiya Tsujinaka, Masashi Neo
BACKGROUND: Objective data on chronic injuries of the medial collateral ligament (MCL) of the ankle are scarce. Chronic MCL injuries are frequently associated with lateral collateral ligament (LCL) injuries. For patients with chronic combined MCL and LCL injuries, the authors have performed simultaneous surgery of the 2 ligaments. HYPOTHESIS: Simultaneous surgery of the 2 ligaments may be effectively used to treat chronic combined MCL and LCL injuries. STUDY DESIGN: Case series; Level of evidence, 4...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28369965/canine-cranial-cruciate-ligament-deficient-stifle-biomechanics-associated-with-extra-articular-stabilization-predicted-using-a-computer-model
#10
Nathan P Brown, Gina E Bertocci, Denis J Marcellin-Little
OBJECTIVE: To evaluate lateral fabellotibial suture (LFTS) and TightRope CCL (TR) extra-articular stabilization biomechanics in the cranial cruciate ligament (CrCL)-deficient canine stifle joint during the stance phase of gait. STUDY DESIGN: Computer simulations. ANIMALS: Healthy 33-kg Golden Retriever. METHODS: LFTS and TR were implemented in a previously developed 3-D quasi-static rigid body CrCL-deficient canine pelvic limb computer model simulating the stance phase of gait...
April 1, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28337591/arthroscopic-r-lcl-plication-for-symptomatic-minor-instability-of-the-lateral-elbow-smile
#11
Paolo Arrigoni, Davide Cucchi, Riccardo D'Ambrosi, Alessandra Menon, Alberto Aliprandi, Pietro Randelli
PURPOSE: Minor instability has been proposed as a possible aetiology of lateral elbow pain. This study presents the results of the arthroscopic plication of the radial component of the lateral collateral ligament (R-LCL) to reduce minor instability of the lateral elbow. METHODS: Twenty-seven patients with recalcitrant lateral epicondylitis who had failed conservative therapy and who had no previous trauma or overt instability, were included. R-LCL plication was performed in the presence of at least one sign of lateral ligamentous patholaxity and one intra-articular abnormal finding...
March 23, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28314869/-operative-treatment-of-terrible-triad-injury-of-the-elbow-open-reduction-and-internal-fixation
#12
R Babst, C Schraner, F J P Beeres
AIM OF SURGERY: Reconstruction of the most important ligamentous and osseus structures of the elbow after terrible triad injury via the radial head to the lateral collateral ligament complex (LCL) and if necessary beginning at the coronoid process. The aim is a stable concentrically guided elbow with early functional follow-up treatment. The approach depends on the intraoperatively tested stability. INDICATIONS: Osteoligamentous terrible triad injury pattern with or without subluxation position following reduction and temporary immobilization...
March 17, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28302426/proximity-of-lateral-critical-structures-to-the-all-epiphyseal-outside-in-femoral-tunnels-in-pediatric-anterior-cruciate-ligament-reconstruction
#13
Mark K Lane, Jennifer Mutch, Kaitlyn Ratkowiak, Stephen E Lemos, Kunal Kalra
PURPOSE: To describe the proximity of the lateral critical structures (peroneal nerve [PN], popliteus tendon [PT], lateral collateral ligament [LCL], and articular cartilage [AC]) to the femoral tunnel for outside-in all-epiphyseal anterior cruciate ligament (ACL) reconstruction in reference to knee flexion angle. METHODS: All-epiphyseal ACL reconstructions were performed in 12 human cadaveric knees using arthroscopy and outside-in drilling for anatomic femoral tunnel placement that was ensured by identifying the center of the total ACL footprint...
March 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28291260/gene-expression-and-proliferation-biomarkers-for-antidepressant-treatment-resistance
#14
J Breitfeld, C Scholl, M Steffens, G Laje, J C Stingl
The neurotrophic hypothesis of depression suggests an association between effects on neuroplasticity and clinical response to antidepressant drug therapy. We studied individual variability in antidepressant drug effects on cell proliferation in lymphoblastoid cell lines (LCLs) from n=25 therapy-resistant patients versus n=25 first-line therapy responders from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Furthermore, the variability in gene expression of genes associated with cell proliferation was analyzed for tentative candidate genes for prediction of individual LCL donor's treatment response...
March 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28291184/lateral-radiographic-landmarks-for-acl-and-lcl-footprint-origins-during-all-epiphyseal-femoral-drilling-in-skeletally-immature-knees
#15
Kevin G Shea, Peter C Cannamela, Peter D Fabricant, E Bailey Terhune, John D Polousky, Matthew D Milewski, Theodore J Ganley, Allen F Anderson
BACKGROUND: This study was conducted to evaluate the spatial relationship of the anterior cruciate ligament (ACL) and lateral collateral ligament (LCL) femoral footprint origins in knee specimens from skeletally immature donors as viewed on lateral radiographs. METHODS: Fourteen cadaver specimens of skeletally immature knees from children between 7 and 11 years old at the time of death were examined through gross dissection. Metallic pins were placed at the center of the ACL and LCL femoral footprints, and computed tomography (CT) scans were performed...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28289158/annexin-a1-is-involved-in-the-resolution-of-inflammatory-responses-during-leishmania-braziliensis-infection
#16
Leandro G Oliveira, Míriam C Souza-Testasicca, Juliana P Vago, Amanda Braga Figueiredo, Adriana M C Canavaci, Luiza Oliveira Perucci, Tatiana P Teixeira Ferreira, Eduardo A F Coelho, Denise Utsch Gonçalves, Manoel Otávio C Rocha, Patrícia M R E Silva, Cláudia N Ferreira, Celso Queiroz-Junior, Lirlândia P Sousa, Ana Paula Fernandes
Leishmaniases are diseases caused by several Leishmania species. Leishmania (Viannia) braziliensis can cause localized cutaneous leishmaniasis (LCL), which heals spontaneously, or mucosal leishmaniasis (ML), characterized by chronic and intense inflammation and scanty parasitism. Annexin A1 (AnxA1) is a protein involved in modulation and resolution of inflammation through multiple mechanisms. In the present study, the role of AnxA1 was investigated in L. braziliensis-infected BALB/c mice. AnxA1 levels increased at the peak of tissue lesion and parasitism in infected mice...
March 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28272413/efficient-and-reliable-establishment-of-lymphoblastoid-cell-lines-by-epstein-barr-virus-transformation-from-a-limited-amount-of-peripheral-blood
#17
Natsue Omi, Yuichi Tokuda, Yoko Ikeda, Morio Ueno, Kazuhiko Mori, Chie Sotozono, Shigeru Kinoshita, Masakazu Nakano, Kei Tashiro
Lymphoblastoid cell lines (LCLs) transformed by Epstein-Barr virus (EBV) serve as an unlimited resource of human genomic DNA. The protocol that is widely used to establish LCLs involves peripheral blood mononuclear cell isolation by density gradient centrifugation, however, that method requires as much as 5 ml of peripheral blood. In this study, in order to provide a more simple and efficient method for the generation of LCLs, we developed a new protocol using hemolytic reaction to enrich white blood cells for EBV transformation and found that the hemolytic protocol successfully generated LCLs from a small volume (i...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28243437/analysis-of-the-cross-talk-of-epstein-barr-virus-infected-b-cells-with-t-cells-in-the-marmoset
#18
Jordon Dunham, Nikki van Driel, Bart Jl Eggen, Chaitali Paul, Bert A 't Hart, Jon D Laman, Yolanda S Kap
Despite the well-known association of Epstein-Barr virus (EBV), a lymphocryptovirus (LCV), with multiple sclerosis, a clear pathogenic role for disease progression has not been established. The translationally relevant experimental autoimmune encephalomyelitis (EAE) model in marmoset monkeys revealed that LCV-infected B cells have a central pathogenic role in the activation of T cells that drive EAE progression. We hypothesized that LCV-infected B cells induce T-cell functions relevant for EAE progression. In the current study, we examined the ex vivo cross-talk between lymph node mononuclear cells (MNCs) from EAE marmosets and (semi-) autologous EBV-infected B-lymphoblastoid cell lines (B-LCLs)...
February 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28237888/cognitive-fatigue-a-time-based-resource-sharing-account
#19
Guillermo Borragán, Hichem Slama, Mario Bartolomei, Philippe Peigneux
Cognitive Fatigue (CF) is an important confound impacting cognitive performance. How CF is triggered and what are the features that make a cognitive effort perceived as exhausting remain unclear. In the theoretical framework of the Time-based Resource-sharing (TBRS) model (Barrouillet et al., 2004), we hypothesized that CF is an outcome of increased cognitive load due to constrained time to process ongoing cognitive demands. We tested this cognitive load-related CF hypothesis across 2 experiments manipulating both task complexity and cognitive load induced by the processing time interval...
February 3, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28219360/interobserver-and-intraobserver-agreement-of-ligamentous-injuries-on-conventional-mri-after-simple-elbow-dislocation
#20
Marc Schnetzke, Svenja Schüler, Johannes Hoffend, Rainer Simon, Holger Keil, Felix Porschke, Stefan Studier-Fischer, Paul-Alfred Grützner, Thorsten Guehring
BACKGROUND: The primary objective of this study was to assess the interobserver and intraobserver agreement on ligamentous injuries on conventional magnetic resonance imaging (MRI) in acute simple elbow dislocation. The secondary objectives were to determine the interobserver agreement on the assessment of joint congruity, joint effusion, loose bodies and chondral lesions on conventional MRI. METHODS: Conventional MRIs (1.5 Tesla, elbow specific surface coil) of 30 patients (40...
February 20, 2017: BMC Musculoskeletal Disorders
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