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https://www.readbyqxmd.com/read/29665801/an-extended-opensim-knee-model-for-analysis-of-strains-of-connective-tissues
#1
M Marieswaran, Arnab Sikidar, Anu Goel, Deepak Joshi, Dinesh Kalyanasundaram
BACKGROUND: OpenSim musculoskeletal models provide an accurate simulation environment that eases limitations of in vivo and in vitro studies. In this work, a biomechanical knee model was formulated with femoral articular cartilages and menisci along with 25 connective tissue bundles representing ligaments and capsules. The strain patterns of the connective tissues in the presence of femoral articular cartilage and menisci in the OpenSim knee model was probed in a first of its kind study...
April 17, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29659700/sex-steroids-drive-the-remodeling-of-oviductal-extracellular-matrix-in-cattle
#2
Angela Maria Gonella-Diaza, Fernando Silveira Mesquita, Everton Lopes, Kauê Ribeiro da Silva, Bruno Cogliati, Ricardo De Francisco Strefezzi, Mario Binelli
The extracellular matrix (ECM) is a group of molecules that offer structural and biochemical support to cells and interact with them to regulate their function. Also, growth factors (GFs) stored in the ECM can be locally released during the ECM remodeling process. Here, we hypothesize that the balance between ECM components and remodelers is regulated according to the ovarian steroid milieu to which the oviduct is exposed during the periovulatory period. Follicular growth was manipulated to generate cows that ovulated small follicles (SF-SCL; n = 20) or large follicles (LF-LCL; n = 21) and possess corresponding Estradiol (E2) and Progesterone (P4) plasmatic concentrations...
April 5, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29656809/lateral-knee-compartment-portals-a-cadaveric-study-defining-a-posterolateral-viewing-safety-zone
#3
Brian Dilworth, Victor Fehrenbacher, John Nyland, Jamie Clark, Joseph W Greene
PURPOSE: This study attempted to define a reproducible "safe zone" based on extra- and intra-articular knee anatomy for placing one or 2 accessory portals in the lateral tibiofemoral compartment for posterolateral region viewing. METHODS: Standard portals were created in 10 cadaveric knees to enable posterolateral region arthroscopic lateral tibiofemoral joint compartment viewing. After identifying the lateral knee surface tissue "soft spot," an accessory posterolateral portal (A) was created using an 18-gauge spinal needle and 4-mm cannula under direct visualization of a 70° arthroscope through the anteromedial portal...
April 12, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29655900/the-anterolateral-ligament-is-a-distinct-ligamentous-structure-a-histological-explanation
#4
Thomas Neri, Pierre Dalcol, Fabien Palpacuer, Florian Bergandi, Jean Michel Prades, Frederic Farizon, Remi Philippot, Michel Peoc'h
BACKGROUND: The aim was to determine whether the anterolateral ligament (ALL) had a histological structure that defined it as a real ligament. METHODS: Histological examination of 30 ALL samples taken from fresh-frozen knees were performed. The ALL femoral insertion and its relationship with the lateral collateral ligament (LCL) were studied and the tibial insertion and its relationship with articular cartilage of the tibial joint surface were analyzed. For the ligamentous part, its histological structure and its differences with the articular capsule were studied...
April 11, 2018: Knee
https://www.readbyqxmd.com/read/29653407/a-new-alzheimer-s-disease-cell-model-using-b-cells-to-induce-beta-amyloid-plaque-formation-and-increase-tnf-alpha-expression
#5
Mehrouz Dezfulian
Different cell models have been developed for the study of Alzheimer's disease (AD) pathways. The neuronal dysfunction and cell death mechanisms that are commonly found in this disease are due to the production of high levels of cytokines and the formation of amyloid plaques. In the cell model introduced in the present study, the production of these two important factors is induced by using B cells from an AD patient. The B cells of an Alzheimer's patient and a normal control were immortalized by using EBV (Epstein-Barr virus) to produce a lymphoblastoid cell line (LCL)...
April 10, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29627149/combined-bilobed-trapezius-myocutaneous-and-scapula-osteomyocutaneous-flaps-for-the-restoration-of-through-and-through-defects-of-the-mandible-following-salvage-surgery-for-recurrent-head-and-neck-tumours
#6
W-L Chen, Z-Q Huang, B Zhou, Y Wang, R Chen
This study was performed to evaluate the outcomes of combined bilobed trapezius myocutaneous and scapula osteomyocutaneous flaps for the restoration of through-and-through defects of the mandible. The subjects were six patients with recurrent malignant tumours who underwent salvage surgeries and reconstruction with combined flaps based on the transverse cervical vessels (TCVs). All patients had combined bone (four type H, one type LCL, and one type C) and extensive soft tissue defects (through-and-through defects) following salvage surgery...
April 4, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29618629/targeted-recruitment-of-the-basal-transcriptional-machinery-by-lnk-clock-components-controls-the-circadian-rhythms-of-nascent-rnas-in-arabidopsis
#7
Yuan Ma, Sergio Gil, Klaus D Grasser, Paloma Mas
The rhythms of steady-state mRNA expression pervade nearly all circadian systems. However, the mechanisms behind the rhythmic transcriptional synthesis and its correlation with circadian expression remain fully unexplored, particularly in plants. Here, we discovered a multi-functional protein complex that orchestrates the rhythms of transcriptional activity in Arabidopsis thaliana. The expression of the circadian oscillator genes TOC1 (TIMING OF CAB EXPRESSION1/PSEUDO-RESPONSE REGULATOR1) and PRR5 (PSEUDO-RESPONSE REGULATOR5) initially relies on the modular function of the clock-related factor RVE8: its MYB domain provides the DNA binding specificity, while its LCL domain recruits the clock components, LNKs, to target promoters...
April 4, 2018: Plant Cell
https://www.readbyqxmd.com/read/29614901/background-distraction-during-vertical-solid-and-character-line-bisections
#8
Julio A Rodriguez, Damon G Lamb, Liliana Salazar, Lauren N Correa, Diana M Mosquera, Zared J Schwartz, Ronald A Cohen, Adam D Falchook, Kenneth M Heilman
Background-objectives: When vertical lines are positioned above or below the center of the page, line bisection deviates toward the center of the page, suggesting that the edges of the page distract the allocation of attention to the line. A letter-character line (LCL) bisection requires both global and focal attention, to identify the target letter closest to the line's center. If more focal and less global attention is allocated to a LCL, more global attentional resources may be available and inadvertently allocated to the page...
April 4, 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29609200/il1rn-variation-influences-both-disease-susceptibility-and-response-to-human-recombinant-il-1ra-therapy-in-systemic-juvenile-idiopathic-arthritis
#9
Victoria L Arthur, Emily Shuldiner, Elaine F Remmers, Anne Hinks, Alexei A Grom, Dirk Foell, Alberto Martini, Marco Gattorno, Seza Özen, Sampath Prahalad, Andrew S Zeft, John F Bohnsack, Norman T Ilowite, Elizabeth D Mellins, Ricardo Russo, Claudio Len, Sheila Oliveira, Rae S M Yeung, Alan M Rosenberg, Lucy R Wedderburn, Jordi Anton, Johannes-Peter Haas, Angela Rösen-Wolff, Kirsten Minden, Ann Marie Szymanski, Wendy Thomson, Daniel L Kastner, Patricia Woo, Michael J Ombrello
OBJECTIVE: To determine whether systemic juvenile idiopathic arthritis (sJIA) susceptibility loci identified by candidate gene studies demonstrated association with sJIA in the largest study population assembled to date. METHODS: Single nucleotide polymorphisms (SNPs) from 11 previously reported sJIA risk loci were examined for association in 9 populations, including 770 sJIA cases and 6947 control subjects. The effect of sJIA-associated SNPs on gene expression was evaluated in silico in paired whole genome and RNA sequencing data from lymphoblastoid cell lines (LCL) of 373 European 1000 Genomes Project subjects...
April 2, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29552473/arthroscopic-repair-of-the-lateral-ulnar-collateral-ligament-of-the-elbow-using-a-knotless-suture-anchor
#10
Eugene T Ek, Kemble K Wang
The lateral collateral ligament (LCL) complex of the elbow plays a crucial role in the stability of the elbow joint, especially to varus loads. Deficiency of particularly the lateral ulnar collateral component of the LCL can lead to chronic posterolateral rotatory instability, which can be functionally debilitating and can lead to a rapid onset of early degenerative arthritis. Commonly, in the setting of acute rupture of the LCL, the ligament is repaired using an open technique with suture anchor fixation to the lateral epicondyle insertion point...
February 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29544463/psychosocial-burden-of-localised-cutaneous-leishmaniasis-a-scoping-review
#11
Issam Bennis, Vincent De Brouwere, Zakaria Belrhiti, Hamid Sahibi, Marleen Boelaert
BACKGROUND: Cutaneous Leishmaniasis (CL) is a parasitic skin disease, linked to poverty, and belonging to the group of Neglected Tropical Diseases. Depending on the severity, the type of lesions or scars, and the context, CL can lead to self- and social stigma influencing the quality of life and psychological well-being of the patient. This dimension is, however, little documented for the most common, localized form of cutaneous leishmaniasis (LCL). We aimed to describe the current knowledge on the psychological burden and the stigma related to LCL...
March 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29543867/toll-like-receptors-2-4-and-9-expressions-over-the-entire-clinical-and-immunopathological-spectrum-of-american-cutaneous-leishmaniasis-due-to-leishmania-v-braziliensis-and-leishmania-l-amazonensis
#12
Marliane Batista Campos, Luciana Vieira do Rêgo Lima, Ana Carolina Stocco de Lima, Thiago Vasconcelos Dos Santos, Patrícia Karla Santos Ramos, Claudia Maria de Castro Gomes, Fernando Tobias Silveira
Leishmania (V.) braziliensis and Leishmania(L.) amazonensis are the most pathogenic agents of American Cutaneous Leishmaniasis in Brazil, causing a wide spectrum of clinical and immunopathological manifestations, including: localized cutaneous leishmaniasis (LCLDTH+/++), borderline disseminated cutaneous leishmaniasis (BDCLDTH±), anergic diffuse cutaneous leishmaniasis (ADCLDTH-), and mucosal leishmaniasis (MLDTH++++). It has recently been demonstrated, however, that while L. (V.) braziliensis shows a clear potential to advance the infection from central LCL (a moderate T-cell hypersensitivity form) towards ML (the highest T-cell hypersensitivity pole), L...
2018: PloS One
https://www.readbyqxmd.com/read/29529702/complex-fibular-head-avulsion-fracture-surgical-management-of-a-case
#13
Vittorio Mattugini, Carmine Citarelli, Fabio Cosseddu, Marco Ghilard, Guido Luppichini, Francesco Casella, Giulio Agostini, Federico Sacchetti, Rodolfo Capanna
Fibular head avulsion fractures are rare injuries determined by traction of the fibular attachment of the lateral collateral ligament (LCL). Surgical treatment is often recommended with different techniques such as tension band fixation or lag screws stabilization. In this article, we describe a fixation technique of fibular head fractures obtained through the use of anchors. A 45-year-old athletic patient came to our attention in our traumatologic service after a motorcycle accident. He reported a complex injury of the posterolateral corner with an avulsion fracture of the left fibular head...
March 12, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29498196/prescription-opioid-use-before-and-after-kidney-transplant-implications-for-post-transplant-outcomes
#14
K L Lentine, N N Lam, A S Naik, D A Axelrod, Z Zhang, V R Dharnidharka, G P Hess, D L Segev, R Ouseph, H Randall, T Alhamad, R Devraj, R Gadi, B L Kasiske, D C Brennan, M A Schnitzler
Evolving literature suggests that the epidemic of prescription opioid use affects the transplant population. We examined a novel database wherein national U.S. transplant registry records were linked to a large pharmaceutical claims warehouse (2007 to 2015) to characterize prescription opioid use before and after kidney transplant, and associations (adjusted hazard ratio,95% LCL aHR95% UCL ) with death and graft loss. Among 75,430 eligible patients, 43.1% filled opioids in the year before transplant. Use was more common among recipients who were women, white, unemployed, publicly insured, and with longer pre-transplant dialysis...
March 2, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29481560/failure-of-fluconazole-in-treating-cutaneous-leishmaniasis-caused-by-leishmania-guyanensis-in-the-brazilian-amazon-an-open-nonrandomized-phase-2-trial
#15
Valeska Albuquerque Francesconi, Fabio Francesconi, Rajendranath Ramasawmy, Gustavo Adolfo Sierra Romero, Maria das Graças Costa Alecrim
BACKGROUND: The treatment of Leishmaniasis caused by Leishmania (Viannia) guyanensis is based on a weak strength of evidence from very few clinical trials and some case series reports. Current treatment guidelines recommend pentamidine isethionate or meglumine antimoniate (Glucantime) as the first-line choices. Both are parenteral drugs with a low therapeutic indexes leading to a high risk of undesired effects. Imidazole derivatives interfere with the production of leishmanial ergosterol, an essential component of their membrane structure...
February 26, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29477042/anti-angiogenic-and-anti-inflammatory-effects-of-long-circulating-liposomes-co-encapsulating-curcumin-and-doxorubicin-on-c26-murine-colon-cancer-cells
#16
Alina Sesarman, Lucia Tefas, Bianca Sylvester, Emilia Licarete, Valentin Rauca, Lavinia Luput, Laura Patras, Manuela Banciu, Alina Porfire
BACKGROUND: Emerging treatment options for colon cancer are needed to overcome the limitations regarding the side effects of current chemotherapeutics and drug resistance. The goal of this study was to assess the antitumor actions of PEGylated long-circulating liposomes (LCL) co-delivering curcumin (CURC) and doxorubicin (DOX) on murine colon carcinoma cells (C26). METHODS: The cytotoxicity of CURC and DOX, administered alone or in combination, either in free or LCL form, was evaluated with regard to antiproliferative effects on C26 cells and to protumor processes that might be affected...
October 16, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29467311/epstein-barr-virus-nuclear-antigen-leader-protein-coactivates-ep300
#17
Chong Wang, Hufeng Zhou, Yong Xue, Jun Liang, Yohei Narita, Catherine Gerdt, Amy Y Zheng, Runsheng Jiang, Stephen Trudeau, Chih-Wen Peng, Benjamin E Gewurz, Bo Zhao
Epstein-Barr virus nuclear antigen (EBNA) leader protein (EBNALP) is one of the first viral genes expressed upon B-cell infection. EBNALP is essential for EBV-mediated B-cell immortalization. EBNALP is thought to function primarily by coactivating EBNA2-mediated transcription. Chromatin immune precipitation followed by deep sequencing (ChIP-seq) studies highlight that EBNALP frequently cooccupies DNA sites with host cell transcription factors (TFs), in particular, EP300, implicating a broader role in transcription regulation...
May 1, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29440688/unbalanced-inflammatory-reaction-could-increase-tissue-destruction-and-worsen-skin-infectious-diseases-a-comparative-study-of-leishmaniasis-and-sporotrichosis
#18
F N Morgado, L M V de Carvalho, J Leite-Silva, A J Seba, M I F Pimentel, A Fagundes, M F Madeira, M R Lyra, M M Oliveira, A O Schubach, F Conceição-Silva
The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29436742/biomechanical-influence-of-deficient-posterolateral-corner-structures-on-knee-joint-kinematics-a-computational-study
#19
Kyoung-Tak Kang, Yong-Gon Koh, Juhyun Son, Moonki Jung, Sangyun Oh, Sung-Jae Kim, Sung-Hwan Kim
The posterolateral corner (PLC) structures including the popliteofibular ligament (PFL), popliteus tendon (PT) and lateral collateral ligament (LCL) are important soft tissues for posterior translational, external rotational and varus angulation knee joint instabilities. The purpose of this study was to determine the effects of deficient PLC structures on the kinematics of the knee joint under gait and squat loading conditions. We developed subject-specific computational models with full 12-degree-of-freedom tibiofemoral and patellofemoral joints for four male subjects and one female subject...
February 13, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29429331/investigation-of-lipid-metabolism-by-a-new-structured-lipid-with-medium-and-long-chain-triacylglycerols-from-cinnamomum-camphora-seed-oil-in-healthy-c57bl-6j-mice
#20
Jiang-Ning Hu, Jin-Rong Shen, Chao-Yue Xiong, Xue-Mei Zhu, Ze-Yuan Deng
In the present study, a new structured lipid with medium- and long-chain triacylglycerols (MLCTs) was synthesized from camellia oil (CO) and Cinnamomum camphora seed oil (CCSO) by enzymatic interesterification. Meanwhile, the antiobesity effects of structured lipid were investigated through observing the changes of enzymes related to lipid mobilization in healthy C57BL/6J mice. Results showed that after synthesis, the major triacylgeride (TAG) species of intesterificated product changed to LaCC/CLaC (12.6 ± 0...
February 14, 2018: Journal of Agricultural and Food Chemistry
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