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https://www.readbyqxmd.com/read/28924447/passive-blood-anaphylaxis-subcutaneous-immunoglobulins-are-a-cause-of-ongoing-passive-anaphylactic-reaction
#1
Przemyslaw Zdziarski, Andrzej Gamian, Jacek Majda, Agnieszka Korzeniowska-Kowal
BACKGROUND: Allergic, especially anaphylactic, reactions during immunoglobulin replacement therapy are rare, but their pathophysiology and classification remain ambiguous. Recent findings show positive results of skin tests with commercially available immunoglobulins, but target antigens and responsible compounds of the tested immunoglobulins have not been strictly identified. CASE DESCRIPTION AND FINDINGS: Four adult patients with recently diagnosed common variable immunodeficiency qualified for standard subcutaneous immunoglobulin replacement therapy regimen...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28912408/-results-of-a-drug-use-survey-of-filgrastim-biosimilar-1-filgrastim-bs-syringe-for-inj-mochida-and-f
#2
Tsukasa Teshima, Nao Takigawa, Yuki Makita, Chinatsu Kushiya
With the aim of evaluating the safety and efficacy of filgrastim biosimilar 1(Filgrastim BS syringe for Inj. "MOCHIDA"and "F"), we conducted a drug use results survey of this product for its indications, including mobilization of hematopoietic stem cells into peripheral blood and chemotherapy-induced neutropenia. Of the 518 cases enrolled between August 2013 and July 2015, 495 were selected to be subjects of our safety and efficacy evaluations. 37 cases (7.47%)experienced side effects, which were mainly lower back pain(19, 3...
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28904280/food-dependent-exercise-induced-anaphylaxis-due-to-ingestion-of-mikan-citrus-unshiu
#3
Yutaka Tanaka, Marie Sugihara, Shuntaro Tsumagari, Nobue Takamatsu, Kazuyuki Kurihara
A 12-year-old girl was referred to our hospital owing to repeated anaphylactic reactions induced by exercise after meals. Food-dependent exercise-induced anaphylaxis (FDEIAn) was suspected. However, sequential tests of typical foods, including egg, milk, soy, and wheat, in combination with exercise, were all negative.The results of the skin prick test (SPT) for Citrus unshiu and specific IgE test for orange and grapefruit were positive. Although no symptoms were noted after an exercise challenge combined with the ingestion of only Citrus unshiu, an anaphylactic reaction was induced by additional acetyl-salicylic acid...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28901381/anti%C3%A2-allergic-action-of-bacillus-calmette%C3%A2-guerin-extract-in-experimental-mast-cell%C3%A2-mediated-anaphylactic-models
#4
Mingli Sun, Yong Wang, Haishan Zhao, Weifan Yao, Xiaosong Yu
Allergy is an acquired hypersensitivity reaction of the immune system mediated by IgE‑induced mast cell degranulation. In China, bacillus Calmette‑Guerin extract (BCGE) has been shown to be clinically effective for regulating immunity, which enhances the resistance of the body to anaphylactic disease, infectious diseases and cancer. However, the mechanisms remain to be fully elucidated. The present study investigated the potential anti‑allergic effects of BCGE in animal models of mast cell‑dependent anaphylaxis and mechanisms of BCGE in mast cells...
August 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900904/lonoctocog-alfa-a-review-in-haemophilia-a
#5
Zaina T Al-Salama, Lesley J Scott
Lonoctocog alfa (rVIII-SingleChain; Afstyla(®)) is a novel single-chain recombinant factor VIII (FVIII) molecule, with a truncated B-domain and the heavy and light chains covalently linked to form a stable and homogenous drug that binds with high affinity to von Willebrand factor (VWF). Intravenous lonoctocog alfa is approved for the prophylaxis and treatment of bleeding in patients with haemophilia A in several countries worldwide. In two pivotal, multicentre trials, lonoctocog alfa was effective in the treatment of bleeding episodes and as prophylaxis, including for perioperative management in adults, adolescents and children...
September 12, 2017: Drugs
https://www.readbyqxmd.com/read/28893913/il17a-deficient-mice-are-highly-susceptible-to-toxoplasma-gondii-infection-due-to-excessively-induced-t-gondii-hsp70-and-ifn-%C3%AE-production
#6
Masataka Moroda, Masaya Takamoto, Yoichiro Iwakura, Jun Nakayama, Fumie Aosai
IL-17A is known to be involved in the host defense against pathogens and pathogenesis of autoimmune diseases. Previously, we showed that excessive IFN-γ plays an important role in the pathogenesis of lethal effect of Toxoplasma gondii (T. gondii) by inducing anaphylactic responses. In this report, we examine the effects of an IL-17A deficiency on murine host defense against oral T. gondii infection. IL-17A-deficient C57BL/6 (B6) mice exhibited higher mortality than wild type (WT) mice to T. gondii at the acute phase of infection...
September 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28888249/do-corticosteroids-prevent-biphasic-anaphylaxis
#7
Waleed Alqurashi, Anne K Ellis
Anaphylaxis is a severe hypersensitivity reaction that is rapid in onset and can result in death. The pattern of an anaphylactic reaction can be uniphasic (or monophasic), biphasic (also called delayed or late phase), or refractory in nature. The most widely cited definition of biphasic anaphylaxis is a recurrence of anaphylactic symptoms after initial resolution despite no further exposure to the trigger. Corticosteroids are thought by some to prevent the development of biphasic symptoms and, therefore, commonly used in the emergency treatment of anaphylaxis but this has not been systemtically analyzed...
September 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28885749/paediatric-food-induced-anaphylaxis-hospital-presentations-in-new-zealand
#8
Sophie Speakman, Bridget Kool, Jan Sinclair, Penny Fitzharris
AIM: Globally, rates of paediatric food-induced anaphylaxis (FIA) are increasing. Little data is available regarding the epidemiology of FIA among New Zealand (NZ) children. This study investigated the incidence of paediatric (0-14 years) FIA hospital presentations in NZ over a 10-year period. METHODS: Ministry of Health public hospital discharge data from 2006 to 2015 were analysed using FIA-related International Classification of Diseases codes (T78.0 - anaphylactic shock due to adverse food reaction and T78...
September 8, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28884986/corticosteroids-in-management-of-anaphylaxis-a-systematic-review-of-evidence
#9
C K Liyanage, P Galappatthy, S L Seneviratne
As anaphylaxis is a medical emergency, there are no randomized controlled clinical trials on its emergency management. Therefore, current guidelines are mostly based on data from observational studies, animal and laboratory studies. Although epinephrine is the mainstay of recommended treatment, corticosteroids are also frequently used. This review evaluates the evidence on the use of corticosteroids in emergency management of anaphylaxis from published human and animal or laboratories studies. Thirty original research papers were found with 22 human studies and eight animal or laboratory studies...
September 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28878810/prevalence-and-clinical-features-of-adverse-food-reactions-in-portuguese-children
#10
Arminda Jorge, Elisa Soares, Emanuel Sarinho, Felix Lorente, Jorge Gama, Luís Taborda-Barata
BACKGROUND: The prevalence of adverse food reactions (AFR) has been increasing in the western world. Clinical manifestations are diversified and it may not be possible to clinically discriminate between IgE and non-IgE mediated AFR. In Portugal, the prevalence of AFR and food allergies in children is not known. Thus, the objectives of this study were to determine the prevalence of AFR in central Portugal. METHODS: Point prevalence study in 3-11 year-old schoolchildren from Central Portugal...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28870153/myocardial-infarction-during-anaphylaxis-in-a-young-healthy-male-with-normal-coronary-arteries-is-epinephrine-the-culprit
#11
W D Jayamali, H M M T B Herath, Aruna Kulathunga
BACKGROUND: Anaphylaxis is an acute, potentially fatal medical emergency. Myocardial injury or infarction in the setting of an anaphylaxis can be due the anaphylaxis itself, when it is known as Kounis syndrome or it can also be due to the effect of epinephrine treatment. Epinephrine is considered as the cornerstone in management of anaphylaxis. Myocardial infarction secondary to therapeutic doses of adrenaline is a rare occurrence and only a few cases have been reported in literature...
September 4, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28846157/allergy-like-immediate-reactions-with-herbal-medicines-in-children-%C3%A2-a-retrospective-study-using-data-from-vigibase-%C3%A2
#12
Ricarda Meincke, Jitka Pokladnikova, Julie Straznicka, Ronald H B Meyboom, David Niedrig, Stefan Russmann, Ludek Jahodar
BACKGROUND: The use of herbal medicines in children and the general population is continually on the rise with an overall herbal lifetime and current use ranging between 0.8-85.5% and 2.2-8.9%, respectively. Although acute hypersensitivity reactions are generally considered to be rare, little knowledge exists on the frequency and type of these reactions especially in specific populations like children. OBJECTIVES: To assess the patterns of acute hypersensitivity reactions to herbal medicines reported to the WHO global individual case safety report (ICSR) database VigiBase(®) in children...
August 28, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28845921/safety-of-hematopoietic-cell-infusion-in-children-with-malignant-and-non-malignant-diseases
#13
Chelsea Heneghan, Elana Smilow, Yvette Tanhehco, Zhezhen Jin, Paige Cofnas, Sharon Schwartz, Nita Patel, Deborah Carberry, Justin Silverman, Paul Huynh, Brittany Hagan, Kim Tobin, Monica Bhatia, Diane George, James Garvin, Prakash Satwani
HPC infusions have been associated with a variety of adverse events related to either patient or HPC product-related factors. Studies documenting infusion-related AEs in children are limited. We reviewed HPC infusion records in 354 children. Infusion-related adverse events were classified as follows: grade 0-absent, grade I-mild, grade II-moderate, grade III-severe, grade IV-life-threatening, and grade V-death. The percentage of patients with grade 0, I, and II-IV AEs was as follows: 0 = 67%, I = 23.4%, and II-V = 9...
August 28, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28830892/life-threatening-intraoperative-anaphylaxis-as-a-result-of-chlorhexidine-present-in-instillagel
#14
Joshua Totty, James Forsyth, Anthony Mekako, Ian Chetter
A 70-year-old man with left lower limb critical ischaemia was admitted to our vascular unit for a femoral-popliteal bypass. He had experienced a skin reaction to chlorhexidine 6 months previously during an angioplasty procedure. After intubation, once in the operating theatre, the patient had a urinary catheter inserted using Instillagel. Around 30 min later the patient had a full-blown anaphylactic reaction that required aggressive medical management and the abandoning of surgery. Postoperative allergy testing confirmed that the suspected primary trigger for the anaphylaxis was indeed chlorhexidine, which was present in Instillagel...
August 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28827807/a-prospective-cohort-study-of-the-effectiveness-of-the-primary-hospital-management-of-all-snakebites-in-kurunegala-district-of-sri-lanka
#15
MULTICENTER STUDY
Seyed Shahmy, Senanayake A M Kularatne, Shantha S Rathnayake, Andrew H Dawson
INTRODUCTION: Sri Lanka records substantial numbers of snakebite annually. Primary rural hospitals are important contributors to health care. Health care planning requires a more detailed understanding of snakebite within this part of the health system. This study reports the management and epidemiology of all hospitalised snakebite in the Kurunegala district in Sri Lanka. METHODOLOGY: The district has 44 peripheral/primary hospitals and a tertiary care hospital-Teaching Hospital, Kurunegala (THK)...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28814352/characteristics-of-drug-induced-anaphylaxis-in-children-and-adolescents
#16
Ozlem Cavkaytar, Betül Karaatmaca, Pınar Gur Cetinkaya, Saliha Esenboga, Ebru Arik Yilmaz, Umit M Sahiner, Bulent E Sekerel, Ozge Soyer
BACKGROUND: Although data on anaphylaxis in the general population exist for different allergens, there is still lack of detailed etiologic data on drug-induced anaphylaxis (DIA), particularly in children. OBJECTIVE: To define the etiology of DIA, to determine the accuracy of drug-related anaphylaxis histories, along with the severity and culprit drug associations among individuals <18 years old. METHODS: Patients with a history of drug hypersensitivity reaction (DHR) referred to our center between January 2012 and February 2016 were included...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28812277/milonine-an-alkaloid-of-cissampelos-sympodialis-eichl-menispermaceae-inhibits-histamine-release-of-activated-mast-cells
#17
Adriano Francisco Alves, Giciane Carvalho Vieira, Francisco Allysson A F Gadelha, Luiz Henrique Agra Cavalcante-Silva, Marco Aurélio Martins, José Maria Barbosa-Filho, Marcia Regina Piuvezam
Milonine is an alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae), a plant used in the northeast of Brazil to treat allergies such as asthma, rhinitis, and other conditions. Previously, several alkaloids were isolated from its roots and leaves with pharmacological properties in asthma and acute inflammation models. Therefore, the aim of this study was to evaluate the milonine effect on mast cells degranulation in vivo and in vitro. Swiss mice (n = 8) were used in models of paw edema induced by carrageenan, compound 48/80, or histamine...
August 15, 2017: Inflammation
https://www.readbyqxmd.com/read/28802031/quality-of-life-among-caregivers-and-growth-in-children-with-parent-reported-food-allergy
#18
Tanya Kajornrattana, Pasuree Sangsupawanich, Araya Yuenyongviwat
BACKGROUND: Some caregivers who believe their children have food allergy avoid feeding certain foods to their children without proper allergy tests. Such actions made without a proper diagnosis can negatively impact the child's health and impose an unnecessary burden on the caregivers. OBJECTIVE: This study aimed to evaluate the caregiver quality of life (QoL) and growth in children with a parent-reported food allergy. METHODS: An observational cross-sectional study was performed in 200 children younger than five years who had a parent-reported food allergy...
August 8, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28798744/the-mast-cell-contact-and-coagulation-system-connection-in-anaphylaxis
#19
REVIEW
Mar Guilarte, Anna Sala-Cunill, Olga Luengo, Moisés Labrador-Horrillo, Victoria Cardona
Anaphylaxis is the most severe form of allergic reaction, resulting from the effect of mediators and chemotactic substances released by activated cells. Mast cells and basophils are considered key players in IgE-mediated human anaphylaxis. Beyond IgE-mediated activation of mast cells/basophils, further mechanisms are involved in the occurrence of anaphylaxis. New insights into the potential relevance of pathways other than mast cell and basophil degranulation have been unraveled, such as the activation of the contact and the coagulation systems...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28793302/safety-of-adrenaline-use-in-anaphylaxis-a-multicentre-register
#20
Victòria Cardona, Laia Ferré-Ybarz, Mar Guilarte, Nuria Moreno-Pérez, Catalina Gómez-Galán, Eva Alcoceba-Borràs, Maria Belén Delavalle, Teresa Garriga-Baraut
BACKGROUND: The use of intramuscular adrenaline to treat anaphylaxis is suboptimal, despite being the first-line treatment recommended by national and international anaphylaxis guidelines. Fear of potentially severe side effects may be one of the underlying factors. The aim of this study was to assess the incidence and severity of adverse side effects after the use of adrenaline in anaphylaxis, as well as potential risk factors. METHODS: Observational study based on a multicenter online registry of cases of adrenaline administration for suspected anaphylaxis...
2017: International Archives of Allergy and Immunology
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