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https://www.readbyqxmd.com/read/28088250/pre-hospital-treatment-of-bee-and-wasp-induced-anaphylactic-reactions-a-retrospective-study
#1
Athamaica Ruiz Oropeza, Søren Mikkelsen, Carsten Bindslev-Jensen, Charlotte G Mortz
BACKGROUND: Bee and wasp stings are among the most common triggers of anaphylaxis in adults representing around 20% of fatal anaphylaxis from any cause. Data of pre-hospital treatment of bee and wasp induced anaphylactic reactions are sparse. This study aimed to estimate the incidence of bee and wasp induced anaphylactic reactions, the severity of the reactions and to correlate the pre-hospital treatment with the severity of the anaphylactic reaction. METHODS: Retrospective and descriptive study based on data from the Mobile Emergency Care Units (MECUs) in the Region of Southern Denmark (2008 only for Odense and 2009-2014 for the whole region)...
January 14, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28072475/safety-of-sulfur-hexafluoride-microbubbles-in-sonography-of-abdominal-and-superficial-organs-retrospective-analysis-of-30-222-cases
#2
Chunlin Tang, Kejing Fang, Yanli Guo, Rui Li, Xiaozhou Fan, Ping Chen, Zhaohui Chen, Qiangwei Liu, Ye Zou
OBJECTIVES: The purpose of this study was to investigate the safety of the sulfur hexafluoride microbubble contrast agent SonoVue (Bracco SpA, Milan, Italy) and to implement precautions with the intent of further improving the safety of this contrast agent. METHODS: A total of 30,222 patients undergoing contrast-enhanced sonography of abdominal and superficial organs in our hospital from January 2005 to December 2014 were retrospectively investigated. SonoVue was used as the ultrasound contrast agent...
January 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28040663/incorporation-of-amoxicillin-loaded-organic-montmorillonite-into-poly-ester-urethane-urea-nanofibers-as-a-functional-tissue-engineering-scaffold
#3
Kui Yu, Tonghe Zhu, Yu Wu, Xiangxiang Zhou, Xingxing Yang, Juan Wang, Jun Fang, Hany El-Hamshary, Salem S Al-Deyab, Xiumei Mo
A dual drug-loaded system is a promising alternative for the sustained drug release system and skin tissue engineering. In this study, a natural sodium montmorillonite (Na-MMT) modified by cetyl trimethyl ammonium bromide (CTAB) was prepared as a carrier to load a model drug - amoxicillin (AMX), the modified organic montmorillonite (CTAB-OMMT) loaded with AMX was marked as AMX@CTAB-OMMT and was subsequently incorporated into poly(ester-urethane) urea (PEUU) and gelatin hybrid nanofibers via electrospinning, resulting in a new drug-loaded nanofibrous scaffold (AMX@CTAB-OMMT-PU75)...
December 23, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28038894/mechanistic-characterization-and-inhibition-of-sphingomyelinase-c-over-substituted-iron-schiff-bases-of-chitosan-adsorbed-on-glassy-carbon-electrode
#4
Claudia A Caro, Luis Lillo, Francisco J Valenzuela, Gerardo Cabello
The medical treatment of laxoscelisms is based solely on supportive measures. Although equine antiserum for Sphingomyelinase C (SMASE) and D isomers are available, it is not used due to the risk of an anaphylactic reaction and its unproven efficacy. As potential enzyme inhibitors, derivatives of Iron chitosan complexes were studied (Shiff base having -R = -H, -Cl, -Br, -F, -OCH3, -CH3, -NO2). These chitosan complexes were chosen because they have revealed good results in medicine and catalysis due to their biodegradable characteristics and bioavailability...
December 27, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28007117/anaphylactic-reaction-secondary-to-topical-preoperative-moxifloxacin
#5
Michael A Ullman, Kirsten J Midgley, Jocelyn Kim, Saul Ullman
: We report a case of anaphylactic shock following topical administration of moxifloxacin for endophthalmitis prophylaxis prior to cataract surgery. Immunoglobulin E (IgE) serology and IgE skin testing confirmed the anaphylactic etiology. Phacoemulsification with posterior chamber intraocular lens implantation was later performed with identical preoperative preparation except for the exclusion of moxifloxacin; no anaphylactic response occurred. To our knowledge, this is the first report of an anaphylactic response to topical moxifloxacin...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28005146/-diagnostics-of-drug-hypersensitivity-reactions
#6
REVIEW
C Möbs, W Pfützner
Drug hypersensitivity reactions comprise approximately 25% of all adverse drug reactions and can be classified into allergic and pseudoallergic drug reactions. Immediate type anaphylactic and delayed type rash reactions of various clinical patterns can be distinguished, depending on the pathogenesis and clinical symptoms. The diagnostic work-up encompasses a thorough but also focused evaluation of the medical history, skin tests and when indicated challenge tests. Furthermore, in vitro tests, such as basophil activation tests and T cell assays not only add valuable additional information but can also yield decisive results for the diagnosis, especially in cases of severe drug reactions or reactions which cannot be further clarified by provocation tests...
December 22, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27999602/anaphylaxis-to-supplemental-oral-lactase-enzyme
#7
M R Voisin, R Borici-Mazi
BACKGROUND: Anaphylactic reactions involving IgE mediated hypersensitivity have been frequently reported for a number of uncommon foods. However, cases of anaphylaxis to over the counter vitamins and oral supplements have been rarely published. Lactose intolerance affects approximately 20% of Canadians and roughly 70% of the world's population of any age. Lactose intolerance develops primarily due to the absence of the enzyme lactase and treatment involves avoidance of lactose-containing foods or ingestion of commercially available lactase enzyme preparations prior to their consumption...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27997286/kounis-syndrome-following-canned-tuna-fish-ingestion
#8
Luisa De Gennaro, Natale Daniele Brunetti, Nicola Locuratolo, Massimo Ruggiero, Manuela Resta, Giuseppe Diaferia, Michele Rana, Pasquale Caldarola
Kounis syndrome (KS) is a complex of cardiovascular symptoms and signs following either allergy or hypersensitivity and anaphylactic or anaphylactoid insults. We report the case of 57-year-old man, with hypertension and history of allergy, referred for facial rash and palpitations appeared after consumption of canned tuna fish. Suddenly, the patient collapsed: electrocardiogram showed ST-elevation in inferior leads. The patient was transferred from the spoke emergency room for coronary angio, which did not show any sign of coronary atherosclerosis...
December 20, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27995273/-partial-response-of-solar-urticaria-to-omalizumab-therapy
#9
L Kowalzick, W Thiel, C Bielfeld, H Ziegler, L Eickenscheidt
The treatment of solar urticaria is regarded as difficult. In some cases good responses to the anti-IgE antibody omalizumab (Xolair®), approved for treatment of chronic spontaneous urticaria, have been reported. We report on a 50-year-old Caucasian woman who for the last 5 years has developed localized itching and stinging erythemas following exposure to sunlight accompanied sometimes by anaphylactic reactions. Oral antihistamines in three- to four-fold doses and a topical sun screen had been only partially effective in long-term use...
December 19, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27994696/primary-hydatid-cyst-of-the-brain-in-a-child-a-case-report
#10
Alessia Imperato, Alessandro Consales, Marcello Ravegnani, Elio Castagnola, Roberto Bandettini, Andrea Rossi
BACKGROUND: Primary intracranial hydatid cyst is a rare location of human echinococcosis whose spontaneous, traumatic or even iatrogenic rupture, as in case of misdiagnosis, may cause anaphylactic reactions and dissemination. CASE REPORT: We discuss the management of a 9-year-old boy who was admitted to our Emergency Department with an intracranial hypertension syndrome. Head CT scan and brain MRI showed a huge intra-axial right temporo-parieto-occipital cyst with a marginal calcification, associated with left ventricular uncompensated hydrocephalus...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27992668/extensively-hydrolyzed-casein-formula-alone-or-with-l-rhamnosus-gg-reduces-%C3%AE-lactoglobulin-sensitization-in-mice
#11
Rosita Aitoro, Raffaele Simeoli, Antonio Amoroso, Lorella Paparo, Rita Nocerino, Claudio Pirozzi, Margherita Di Costanzo, Rosaria Meli, Carmen De Caro, Gianluca Picariello, Gianfranco Mamone, Antonio Calignano, Cathryn R Nagler, Roberto Berni Canani
BACKGROUND: Extensively hydrolyzed casein formula (EHCF) has been proposed for the prevention and is commonly used for the treatment of cow's milk allergy (CMA). The addition of the probiotic Lactobacillus rhamnosus GG (LGG) to EHCF may induces faster acquisition of tolerance to cow's milk. The mechanisms underlying this effect are largely unexplored. We investigated the effects of EHCF alone or in combination with LGG on β-lactoglobulin (BLG) sensitization in mice. METHODS: Three-weeks old C3H/HeOuJ mice were sensitized by oral administration of BLG using cholera toxin as adjuvant at weekly intervals for 5 weeks (sensitization period)...
December 19, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27965927/catastrophic-bronchial-spasm-due-to-a-severe-anaphylactic-reaction-to-protamine
#12
Jae-Bum Kim, Jae Hyun Kim, Kyung Sub Song
Fatal anaphylactic reactions to protamine sulfate during cardiac surgery are very rare. We report a case of catastrophic bronchial spasm due to an anaphylactic reaction to protamine. The patient was managed successfully using a bronchodilator, steroid treatment, and extracorporeal membrane oxygenation.
December 2016: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27965263/primary-intravenous-chemotherapy-for-group-d-retinoblastoma-a-13-year-retrospective-analysis
#13
Ido D Fabian, Andrew W Stacey, Kenneth P Johnson, Zerrin Onadim, Tanzina Chowdhury, Catriona Duncan, M Ashwin Reddy, Mandeep S Sagoo
BACKGROUND: Eye salvage rate for group D retinoblastoma using intravenous chemotherapy (IVC) as a primary modality is <50%. To report on 13 years' experience with the use of primary IVC for group D retinoblastoma. METHODS: A retrospective analysis of 64 group D eyes (52 patients) treated with primary IVC, from 2002 to 2014. RESULTS: The median age at presentation was 11.0 months (mean: 18.6, range: 0.6-144.0), 35 (67%) patients had bilateral disease, 38 (73%) germline disease and 8 (15%) cases were familial...
January 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27951566/new-strategies-for-anaemia-management-in-chronic-kidney-disease
#14
Francesco Locatelli, Lucia Del Vecchio
Erythropoiesis-stimulating agents (ESAs) and iron therapy are the standard of care for normocytic normochromic anaemia, which is a frequent comorbidity of patients with chronic kidney disease. In a large percentage of patients, ESAs and iron increase haemoglobin levels, thus reducing the risk of blood transfusions and improving patient quality of life. However, randomised trials have raised some concerns about higher haemoglobin targets and/or high ESA dose use. These concerns include higher cardiovascular and thrombosis risk, cancer progression, and increased mortality...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/27951562/newly-developed-biocompatible-material-dispersible-titanium-doped-hydroxyapatite-nanoparticles-suitable-for-antibacterial-coating-on-intravascular-catheters
#15
Tsutomu Furuzono, Masatoshi Okazaki, Yoshinao Azuma, Mitsunobu Iwasaki, Yasumichi Kogai, Yoshiki Sawa
BACKGROUND: Thirteen patients with chlorhexidine-silver sulfadiazine-impregnated catheters have experienced serious anaphylactic shock in Japan. These adverse reactions highlight the lack of commercially available catheters impregnated with strong antibacterial chemical agents. A system should be developed that can control both biocompatibility and antibacterial activity. SUMMARY: Hydroxyapatite (HAp) is biocompatible with bone and skin tissues. To provide antibacterial activity by using an external physical stimulus, titanium (Ti) ions were doped into the HAp structure...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/27936684/purification-and-characterization-of-a-black-walnut-juglans-nigra-allergen-jug-n-4
#16
Yu-Zhu Zhang, Wen-Xian Du, Yuting Fan, Jiang Yi, Shu-Chen Lyu, Kari C Nadeau, Andrew L Thomas, Tara McHugh
Tree nuts as a group cause a significant number of fatal anaphylactic reactions to foods. Walnuts (Juglans spp.) are one of the leading causes of allergic reactions to tree nuts in the U.S. and Japan. The purpose of this study was to purify and characterize potential food allergens from black walnut. Here, we report the isolation of the black walnuts allergen Jug n 4 (an 11S globulin) by ammonium sulfate precipitation, hydrophobic interaction, and size exclusion chromatography. Reducing SDS-PAGE analysis indicated that purified Jug n 4 consists of three major bands...
January 5, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27920822/anti-anaphylactic-effects-of-trichilia-monadelpha-thonn-j-j-de-wilde-extracts-on-rodent-models-of-anaphylaxis
#17
Inemesit Okon Ben, Eric Woode, George Asumeng Koffuor, Emmanuel Akomanin Asiamah
Effects of petroleum ether and ethanolic extracts of Trichilia monadelpha stem bark (PEE and EAE) on compound 48/80-induced systemic and passive anaphylaxis were determined. Survival rate, extravasation, degranulation of mast cells, and secretion of tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were measured after pre-treatment with extracts (10-100 mg/kg) and disodium chromoglycate (2.5-250 μg/kg) and induction of anaphylaxis in C57BL/6 mice or Sprague-Dawley rats with compound 48/80. Histopathological assessments were made from skin biopsies of rats...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27914063/episweep-computationally-driven-reengineering-of-therapeutic-proteins-to-reduce-immunogenicity-while-maintaining-function
#18
Yoonjoo Choi, Deeptak Verma, Karl E Griswold, Chris Bailey-Kellogg
Therapeutic proteins are yielding ever more advanced and efficacious new drugs, but the biological origins of these highly effective therapeutics render them subject to immune surveillance within the patient's body. When recognized by the immune system as a foreign agent, protein drugs elicit a coordinated response that can manifest a range of clinical complications including rapid drug clearance, loss of functionality and efficacy, delayed infusion-like allergic reactions, more serious anaphylactic shock, and even induced auto-immunity...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27906697/allergen-immunotherapy-an-updated-review-of-safety
#19
Christine James, David I Bernstein
PURPOSE OF REVIEW: Allergen immunotherapy is the only modality that can modify the immune response upon exposure to aeroallergens and venom allergens. This review will update the allergist on recent studies evaluating safety of sublingual and subcutaneous allergen immunotherapy. RECENT FINDINGS: Multiple clinical trials and retrospective studies have been published evaluating overall safety of these therapies. The risk of systemic reactions with subcutaneous immunotherapy remains quite low, but near-fatal and fatal anaphylaxis does occur, requiring physicians to be aware of potential risks for such events...
February 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27902669/an-anaphylactoid-reaction-to-rattlesnake-envenomation-in-a-pediatric-patient
#20
Logan Rencher, Joanna Schwartz, Alexandra Wilson
Rattlesnake envenomation causes a spectrum of symptoms and signs, many of which closely resemble an anaphylactic reaction. Development of airway compromise after a snake bite to an extremity is unusual, but has been previously reported. The majority of such reports detail a history of probable sensitization from previous contact with snakes or snake venom. Few reports exist without such previous contact; no reports are of pediatric cases. Here we present a 14-year-old boy with no history of prior snake exposure who presents with an anaphylactoid reaction after a rattlesnake bite...
November 29, 2016: Pediatric Emergency Care
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