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https://www.readbyqxmd.com/read/29912642/investigation-of-the-potential-for-a-simplified-exposure-tool-in-medical-nutrition-setim-to-minimise-exposures-to-sweeteners-in-young-patients-aged-1-3-years-with-pku-and-cmpa
#1
Aaron J O'Sullivan, Cian O'Mahony, Leo Meunier, Nik Loveridge, Aideen I McKevitt
Children with Phenylketonuria (PKU) and severe cow's milk protein allergy (CMPA) consume prescribed, specially formulated, foods for special medical purposes (FSMPs) in addition to having restricted intake of normal foods. These vulnerable patients are exposed to artificial sweeteners from the consumption of a combination of both free and prescribed foods. Young patients with PKU and CMPA aged from 1-3 years have a higher risk of exceeding the acceptable daily intake (ADI) for sweeteners than age-matched healthy children...
June 18, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29911211/the-global-allergy-and-asthma-european-network-galen-rhinosinusitis-cohort-a-large-european-cross-sectional-study-of-chronic-rhinosinusitis-patients-with-and-without-nasal-polyps
#2
A Khan, G Vandeplas, T M T Huynh, V N Joish, L Mannent, P Tomassen, T Van Zele, L O Cardell, J Arebro, H Olze, U Foerster-Ruhrmann, M L Kowalski, A Olszewska-Ziaber, G Holtappels, N De Ruyck, C van Drunen, J Mullol, P W Hellings, V Hox, E Toskala, G Scadding, V J Lund, W J Fokkens, C Bachert
BACKGROUND: Chronic rhinosinusitis (CRS) is a common yet under-recognised chronic inflammatory disease of the nose and paranasal sinuses that is classified according to the presence (CRSwNP) or absence (CRSsNP) of nasal polyps. METHODS: This paper reports the methodology and descriptive results of the Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort. We established a large CRS cohort within the GALEN consortium (European FP6 research initiative) to identify inflammatory endotypes, the natural disease course, and its impact on health-related quality of life (HRQoL)...
June 17, 2018: Rhinology
https://www.readbyqxmd.com/read/29910462/the-rise-and-rise-of-eosinophilic-gut-diseases-including-eosinophilic-esophagitis-is-probably-not-explained-by-the-disappearance-of-helicobacter-pylori-so-who-or-what-s-to-blame
#3
EDITORIAL
Nicholas J Talley, Marjorie M Walker
A dramatic increase in eosinophilic esophagitis (EoE) and atopic disease and a dramatic decline in Helicobacter pylori infection has been observed in the last few decades. Previously, it was speculated that the immune response to H. pylori may protect against allergic diseases including EoE, but this study by Molina-Infante et al. shows no clear relationship, and suggests that any correlation is not causal. In truth it is likely that a combination of many factors, including a changing microbiome with increasing hygiene and alterations in early life such as antibiotic exposure, changing diet and other lifestyle factors drive increasing atopic diseases including food allergies and EoE...
June 18, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29909054/the-challenges-of-preventing-food-allergy-lessons-learned-from-leap-and-eat
#4
REVIEW
Helen Fisher, George Du Toit, Henry T Bahnson, Gideon Lack
No abstract text is available yet for this article.
June 14, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29908992/accidental-food-allergy-reactions-products-and-undeclared-ingredients
#5
W Marty Blom, Anouska D Michelsen-Huisman, Harmieke van Os-Medendorp, Gert van Duijn, Mary-Lène de Zeeuw-Brouwer, Astrid Versluis, Jacqueline J M Castenmiller, Hubert P J M Noteborn, Astrid G Kruizinga, André C Knulst, Geert F Houben
BACKGROUND: Accidental allergic reactions to food are frequent, can be severe and even fatal. OBJECTIVE: To analyze the culprit food products and levels of unexpected allergens in accidental reactions. METHODS: A prospective cohort study was conducted in adults (n=157) with a physician-confirmed diagnosed food allergy. During a 1-year follow up, 73 patients reported accidental allergic reactions and the culprit food products. Food samples received (51) were analyzed for a wide range of suspected non-ingredient allergens and the risk was quantified...
June 14, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29908547/oral-immunotherapy-to-wheat-in-allergic-asthmatic-female-a-case-report
#6
Ioana Adriana Muntean, Ioana Corina Bocsan, Diana Deleanu
Wheat is the most commonly grown cereal. Immunological reaction to wheat may be IgE or T-cell- mediated. Asthma could be induced by inhaled flour or by exposure to allergens present in bakery products. In patients with IgE-mediated allergy to wheat proteins there is no specific therapy, except oral immunotherapy (OIT). There are few data regarding OIT with wheat protein in allergic patients. We present a case of a 32-yearold female patient, who worked for 5 years in wheat and bakery products industry, who developed an occupational asthma and chronic urticaria after flour inhalation or ingestion of foods that containit...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29904971/a-subset-of-walnut-allergic-adults-is-sensitized-to-walnut-11s-globulin-jug-r-4
#7
Mark A Blankestijn, Constance F den Hartog Jager, W Marty Blom, Henny G Otten, G Aard H de Jong, Marco Gaspari, Geert F Houben, André C Knulst, Kitty C M Verhoeckx
BACKGROUND: The role of sensitization to commercially available allergens of English walnut (Juglans regia) Jug r 1, 2 and 3 in walnut allergy has been previously investigated in walnut allergic adults and was unable to explain allcases of walnut allergy. OBJECTIVES: Identify recognized walnut allergens, other than the ones previously investigated (Jug r 1-3), in walnut allergic adults and determine the sensitization frequency and diagnostic value. METHODS: Three different in-house walnut extracts were prepared and analysed on SDS-PAGE blots to identify allergenic walnut proteins...
June 15, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29904820/food-induced-anaphylaxis-an-update
#8
REVIEW
Christopher P Parrish, Heidi Kim
PURPOSE OF REVIEW: This review aims to provide an update of recent advances in the epidemiology, clinical features and diagnosis, and management of food-induced anaphylaxis (FIA). RECENT FINDINGS: Food allergy prevalence and FIA rates continue to rise, but FIA fatalities are stable. Basophil and mast cell activation tests promise more accurate identification of food triggers. Oral, sublingual, and epicutaneous immunotherapy can desensitize a significant portion of subjects...
June 14, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29903523/student-and-parent-perspectives-on-severe-food-allergies-at-college
#9
Anne L Ersig, Janet K Williams
INTRODUCTION: Constant vigilance to manage severe food allergies (FAs) can lead to high stress. Additional stress may develop during life-course transitions, such as the transition to college. However, few studies have evaluated everyday and FA-related stress in college students with FA and their parents. This analysis examined experiences of 26 college students with FA and their parents. METHODS: Students and parents completed online surveys in a mixed-methods exploratory study of everyday and FA-related stressors, potential contributing factors, and FA management...
June 12, 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29902173/effect-of-tomato-variety-cultivation-climate-and-processing-on-sola-l-4-an-allergen-from-solanum-lycopersicum
#10
Elisabeth Kurze, Roberto Lo Scalzo, Gabriele Campanelli, Wilfried Schwab
Tomatoes (Solanum lycopersicum) are one of the most consumed vegetables worldwide. However, tomato allergies in patients suffering from birch pollen allergy occur frequently. Due to highly similar protein structures of the tomato allergen Sola l 4 and the major birch pollen allergen Bet v 1, patients cross-react with allergenic proteins from tomato as well as other fruits or vegetables. The aim of this study was to quantify Sola l 4 in various tomatoes differing in color, size and shape for identification of varieties with a reduced allergen level...
2018: PloS One
https://www.readbyqxmd.com/read/29896198/morphological-and-functional-characterization-of-il-12r%C3%AE-2-chain-on-intestinal-epithelial-cells-implications-for-local-and-systemic-immunoregulation
#11
Mari Regoli, Angela Man, Nadhezda Gicheva, Antonio Dumont, Kamal Ivory, Alessandra Pacini, Gabriele Morucci, Jacopo J V Branca, Monica Lucattelli, Ugo Santosuosso, Arjan Narbad, Massimo Gulisano, Eugenio Bertelli, Claudio Nicoletti
Interaction between intestinal epithelial cells (IECs) and the underlying immune systems is critical for maintaining intestinal immune homeostasis and mounting appropriate immune responses. We have previously showed that the T helper type 1 (TH 1) cytokine IL-12 plays a key role in the delicate immunological balance in the gut and the lack of appropriate levels of IL-12 had important consequences for health and disease, particularly with regard to food allergy. Here, we sought to understand the role of IL-12 in the regulation of lymphoepithelial cross talk and how this interaction affects immune responses locally and systemically...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29895780/vitamins-a-and-e-during-pregnancy-and-allergy-symptoms-in-an-early-childhood-lack-of-association-with-tobacco-smoke-exposure
#12
Jolanta Gromadzinska, Kinga Polanska, Lucyna Kozlowska, Karolina Mikolajewska, Iwona Stelmach, Joanna Jerzyńska, Włodzimierz Stelmach, Mariusz Grzesiak, Wojciech Hanke, Wojciech Wasowicz
Epidemiological studies have suggested an association between maternal antioxidant levels during pregnancy and development of allergic diseases in their offspring. The aim of the study was to determine plasma vitamins A and E concentration in the 1st trimester of pregnancy, at delivery and in cord blood and to search for a relationship with allergy in up to 2-year-old children who were prenatally exposed or not exposed to tobacco smoke. The study participants included 252 mother-child pairs from Polish Mother and Child Cohort...
June 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29895510/food-allergy-training-for-schools-and-restaurants-the-food-allergy-community-program-protocol-to-evaluate-the-effectiveness-of-a-web-based-program
#13
Inês Pádua, André Moreira, Pedro Moreira, Renata Barros
BACKGROUND: Food allergy is a growing public health concern. The literature suggests that a significant number of reactions occur in community services, such as schools and restaurants. Therefore, suitable training and education for education and catering professionals using viable and practical tools is needed. OBJECTIVE: The objective of this study is to evaluate the effectiveness of a Web-based food allergy training program for professionals working in schools and restaurants, designed to improve knowledge and good practices in the community...
June 12, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29895304/adaptation-and-validation-of-a-food-frequency-questionnaire-ffq-to-assess-dietary-intake-in-moroccan-adults
#14
Khaoula El Kinany, Vanessa Garcia-Larsen, Mohamed Khalis, Meimouna Mint Sidi Deoula, Abdelilah Benslimane, Amran Ibrahim, Mohamed Chakib Benjelloun, Karima El Rhazi
BACKGROUND: To date, no culture-specific food frequency questionnaires (FFQ) are available in North Africa. The aim of this study was to adapt and examine the reproducibility and validity of an FFQ or use in the Moroccan population. METHODS: The European Global Asthma and Allergy Network (GA2 LEN) FFQ was used to assess its applicability in Morocco. The GA2 LEN FFQ is comprised of 32 food sections and 200 food items. Using scientific published literature, as well as local resources, we identified and added foods that were representative of the Moroccan diet...
June 12, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29895253/the-atopic-dermatitis-and-food-allergy-a-paediatric-approach
#15
Natalia Cartledge, Susan Chan
Atopic dermatitis and food allergy are common conditions of childhood that are closely linked. 30% of children with moderate to severe eczema suffer from food allergy and can present with different types of reactions: immediate or IgE-mediated reactions, delayed or non-IgE-mediated eczematous flares, or a combination of the two. A detailed history is very important when approaching such patients. The presence of IgE-mediated symptoms warrants investigation and management requires avoidance of the culprit allergen, an emergency care plan and appropriate follow up...
June 12, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29894999/grass-allergic-children-frequently-show-asymptomatic-low-level-ige-co-sensitization-and-cross-reactivity-to-wheat
#16
Nora Nilsson, Caroline Nilsson, Helena Ekoff, Sandra Wieser-Pahr, Magnus P Borres, Rudolf Valenta, Gunilla Hedlin, Sigrid Sjölander
BACKGROUND: Specific immunoglobulin E (IgE) sensitization to wheat is more common than a doctor's confirmed wheat allergy and is also frequently observed in grass pollen-allergic patients (pollinosis patients). Thus, the objective of this study was to investigate the level and feature of serological IgE cross-reactivity between grass pollen and wheat in a cohort of pollinosis subjects with no diagnosis of wheat allergy. METHODS: Seventy-two children, aged 5-17 years, with a doctor's diagnosis of pollinosis, IgE towards grass pollen, and currently eating wheat were recruited...
June 12, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29893145/parental-reports-of-lunch-packing-behaviours-lack-accuracy-reported-barriers-and-facilitators-to-packing-school-lunches
#17
Dana L Hawthorne, Lisa J Neilson, Lesley A Macaskill, Jonathan M H Luk, Erica J Horner, Colleen A Parks, Marina I Salvadori, Jamie A Seabrook, Paula D N Dworatzek
PURPOSE: Parents influence the foods their children consume and often provide proxy reports of this intake. One way parents exert this influence is by providing home-packed lunches. This study compared parental reports of foods packed in children's lunches with what was actually packed and identified parental barriers and facilitators to packing lunches. METHODS: Grade 3 and 4 student-parent dyads (n = 321) in 19 elementary schools in Ontario participated. Parental reports and actual packed lunch contents were collected via self-administered surveys and direct observation, respectively...
June 12, 2018: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/29890625/hepatic-mitochondrial-dysfunction-and-immune-response-in-a-murine-model-of-peanut-allergy
#18
Giovanna Trinchese, Lorella Paparo, Rosita Aitoro, Carmela Fierro, Michela Varchetta, Rita Nocerino, Maria Pina Mollica, Roberto Berni Canani
BACKGROUND: Evidence suggests a relevant role for liver and mitochondrial dysfunction in allergic disease. However, the role of hepatic mitochondrial function in food allergy is largely unknown. We aimed to investigate hepatic mitochondrial dysfunction in a murine model of peanut allergy. METHODS: Three-week-old C3H/HeOuJ mice were sensitized by the oral route with peanut-extract (PNT). We investigated: 1. the occurrence of effective sensitization to PNT by analysing acute allergic skin response, anaphylactic symptoms score, body temperature, serum mucosal mast cell protease-1 (mMCP-1) and anti-PNT immunoglobulin E (IgE) levels; 2...
June 8, 2018: Nutrients
https://www.readbyqxmd.com/read/29887498/structural-and-dynamic-properties-of-allergen-and-non-allergen-forms-of-tropomyosin
#19
Jose K James, Douglas H Pike, I John Khan, Vikas Nanda
To what extent do structural and biophysical features of food allergen proteins distinguish them from other proteins in our diet? Invertebrate tropomyosins (Tpms) as a class are considered "pan-allergens," inducing food allergy to shellfish and respiratory allergy to dust mites. Vertebrate Tpms are not known to elicit allergy or cross-reactivity, despite their high structural similarity and sequence identity to invertebrate homologs. We expect allergens are sufficiently stable against gastrointestinal proteases to survive for immune sensitization in the intestines, and that proteolytic stability will correlate with thermodynamic stability...
May 22, 2018: Structure
https://www.readbyqxmd.com/read/29886072/study-of-the-allergenic-potential-of-bacillus-thuringiensis-cry1ac-toxin-following-intra-gastric-administration-in-a-murine-model-of-food-allergy
#20
Karla I Santos-Vigil, Damaris Ilhuicatzi-Alvarado, Ana L García-Hernández, Juan S Herrera-García, Leticia Moreno-Fierros
Cry1Ac toxin, from Bacillus thuringiensis, is widely used as a biopesticide and expressed in genetically modified (GM) plants used for human and animal consumption. Since Cry1Ac is also immunogenic and able to activate macrophages, it is crucial to thoroughly evaluate the immunological effects elicited after intra-gastric administration. The allergenic potential of purified Cry1Ac was assessed and compared with that induced in a murine model of food-allergy to ovalbumin (OVA), in which animals are sensitized with the adjuvant Cholera toxin (CT)...
June 7, 2018: International Immunopharmacology
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