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https://www.readbyqxmd.com/read/29470978/contractile-responses-to-endothelin-1-are-regulated-by-pkc-phosphorylation-of-cardiac-myosin-binding-protein-c-in-rat-ventricular-myocytes
#1
Ioannis Smyrnias, Normann Goodwin, Dagmar Wachten, Jonas Skogestad, Jan Magnus Aronsen, Emma L Robinson, Kateryna Demydenko, Anne Segonds-Pichon, David Oxley, Sakthivel Sadayappan, Karin Sipido, Martin D Bootman, H Llewelyn Roderick
The shortening of sarcomeres that co-ordinates the pump function of the heart is stimulated by electrically-mediated increases in [Ca2+ ]. This process of excitation-contraction coupling (ECC) is subject to modulation by neurohormonal mediators that tune the output of the heart to meet the needs of the organism. Endothelin-1 (ET-1) is a potent modulator of cardiac function with effects on contraction amplitude, chronotropy and automaticity. The actions of ET-1 are evident during normal adaptive physiological responses and increased under pathophysiological conditions, such as following myocardial infarction and during heart failure, where ET-1 levels are elevated...
February 19, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29466490/heart-transplantation-for-peripartum-cardiomyopathy-a-single-center-experience
#2
Nadia Bouabdallaoui, Pierre Demondion, Sylvestre Maréchaux, Shaida Varnous, Guillaume Lebreton, Frédéric Mouquet, Pascal Leprince
BACKGROUND: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. OBJECTIVE: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). METHODS: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM...
February 19, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29463462/vasoactive-inotropic-score-as-a-predictor-of-mortality-in-adult-patients-with-cardiogenic-shock-medical-therapy-versus-ecmo
#3
Soo Jin Na, Chi Ryang Chung, Yang Hyun Cho, Kyeongman Jeon, Gee Young Suh, Joong Hyun Ahn, Keumhee C Carriere, Taek Kyu Park, Ga Yeon Lee, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Jeong Hoon Yang
INTRODUCTION AND OBJECTIVES: This study investigated whether the vasoactive inotropic score (VIS) is independently predictive of mortality in cardiogenic shock (CS). METHODS: This study was retrospective, observational study. Patients who were admitted to the cardiac intensive care unit from January 2012 to December 2015 were screened, and 493 CS patients were finally enrolled. To quantify pharmacologic support, the patients were divided into 5 groups based on a quintile of VIS: 1 to 10, 11 to 20, 21 to 38, 39 to 85, and > 85...
February 17, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29461833/a-systematic-exploration-of-macrocyclization-in-apelin-13-impact-on-binding-signaling-stability-and-cardiovascular-effects
#4
Kien Tran, Alexandre Murza, Xavier Sainsily, David Coquerel, Jérôme Côté, Karine Belleville, Lounès Haroune, Jean-Michel Longpré, Robert Dumaine, Dany Salvail, Olivier Lesur, Mannix Auger-Messier, Philippe Sarret, Éric Marsault
The apelin receptor generates increasing interest as a potential target across several cardiovascular indications. However, the short half-life of its cognate ligands, the apelin peptides, is a limiting factor for pharmacological use. In this study, we systematically explored each position of apelin-13 to find the best position to cyclize the peptide, with the goal to improve its stability while optimizing its binding affinity and signaling profile. Macrocyclic analogues showed a remarkably higher stability in rat plasma (half-life > 3 h versus 24 min for Pyr-apelin-13), accompanied with improved affinity (analogue 15, Ki 0...
February 20, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29461278/home-inotropes-in-patients-supported-with-left-ventricular-assist-devices
#5
Emeka C Anyanwu, Viktoriya Kagan, Ankit Bhatia, David M Tehrani, Sirtaz Adatya, Gene Kim, Nitasha Sarswat, Valluvan Jeevanandam, Gabriel Sayer, Nir Uriel
There is little data outlining the use of outpatient inotropic medications in patients with existing left ventricular assist devices (LVADs). This case series explores this patient population and seeks to define the indications, complications, and safety of dual support. A retrospective chart review was conducted for all patients on LVAD and then subsequently started on home inotropes post device implant. Eight patients met inclusion criteria. The indications for inotropes were right ventricular failure, aortic insufficiency with biventricular failure, LVAD thrombosis with contraindication to device exchange, and cannula malposition with elevated pulmonary vascular resistance...
February 15, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29460801/effects-of-glucocorticoids-on-serum-amino-acid-levels-during-cardiac-surgery-in-children
#6
Annelies van Zwol, Neelke B C Oosterloo, Cartijn T de Betue, Ad Bogers, Inge I de Liefde, Nicolaas E P Deutz, Koen F M Joosten
BACKGROUND AND AIMS: Children undergoing cardiac surgery with cardio pulmonary bypass often receive glucocorticoids to reduce the systemic inflammatory response. Glucocorticoids stimulate protein breakdown and increase amino acid availability. We studied whether glucocorticoid treatment influences the availability of amino acids, specifically those involved in the nitric oxide pathway. METHODS: We prospectively studied 49 children with congenital heart disease undergoing cardiac surgery...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460575/guidelines-for-treatment-of-sepsis
#7
Erik Refsland Kaspersen, Johan Ræder, Vegard Dahl
BAKGRUNN: Det finnes internasjonale og nasjonale retningslinjer for behandling av sepsis. I tillegg har nesten alle norske sykehus utarbeidet egne retningslinjer for behandling av tilstanden. Formålet med denne studien var å vurdere i hvilken grad de lokale retningslinjene stemmer overens med de nasjonale. MATERIALE OG METODE: Alle offentlige norske sykehus med indremedisinsk akuttfunksjon ble kontaktet og forespurt om lokale retningslinjer for behandling av sepsis...
February 19, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29460374/del-nido-cardioplegia-for-minimally-invasive-aortic-valve-replacement
#8
Michael S Koeckert, Deane E Smith, Patrick F Vining, Neel K Ranganath, Thomas Beaulieu, Didier F Loulmet, Elias Zias, Aubrey C Galloway, Eugene A Grossi
BACKGROUND: We analyzed the impact and safety of del Nido Cardioplegia (DNC) in patients undergoing minimally invasive aortic valve replacement (MIAVR). METHODS: We analyzed all isolated MIAVR replacements from 5/2013-6/2015 excluding re-operative patients. The approach was a hemi-median sternotomy in all patients. Patients were divided into two cohorts, those who received 4:1 crystalloid:blood DNC solution and those in whom standard 1:4 Buckberg-based cardioplegia (WBC) was used...
February 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29459321/bioengineering-an-electro-mechanically-functional-miniature-ventricular-heart-chamber-from-human-pluripotent-stem-cells
#9
Ronald A Li, Wendy Keung, Timothy J Cashman, Peter C Backeris, Bryce V Johnson, Evan S Bardot, Andy O T Wong, Patrick K W Chan, Camie W Y Chan, Kevin D Costa
Tissue engineers and stem cell biologists have made exciting progress toward creating simplified models of human heart muscles or aligned monolayers to help bridge a longstanding gap between experimental animals and clinical trials. However, no existing human in vitro systems provide the direct measures of cardiac performance as a pump. Here, we developed a next-generation in vitro biomimetic model of pumping human heart chamber, and demonstrated its capability for pharmaceutical testing. From human pluripotent stem cell (hPSC)-derived ventricular cardiomyocytes (hvCM) embedded in collagen-based extracellular matrix hydrogel, we engineered a three-dimensional (3D) electro-mechanically coupled, fluid-ejecting miniature human ventricle-like cardiac organoid chamber (hvCOC)...
February 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29455831/thoracoscopic-sympathectomy-for-refractory-electrical-storm-after-coronary-artery-bypass-grafting
#10
Brody Wehman, Michael Mazzeffi, Robert Chow, A Claire Watkins, Brittany Aicher, Si Pham, Whitney Burrows, Bradley Taylor
We report a patient with refractory electrical storm after coronary artery bypass grafting who was successfully treated with thoracoscopic sympathectomy. Cardiac arrest with ventricular tachycardia occurred on postoperative day 2, and the patient required emergency support with venoarterial extracorporeal membrane oxygenation. Frequent episodes of ventricular tachycardia prevented cardiac recovery and weaning from mechanical circulatory support. A percutaneous left stellate ganglion block initially demonstrated successful prevention of ventricular tachycardia, and definitive sympathetic denervation was achieved by a left thoracoscopic sympathectomy...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29453133/mortality-after-emergency-abdominal-operations-in-premature-infants
#11
Sarah B Cairo, Benjamin D Tabak, Loren Berman, Sara K Berkelhamer, Guan Yu, David H Rothstein
CONTEXT/BACKGROUND: To determine risk of 30-day mortality for premature infants undergoing abdominal operations during the first 2 months of life and to identify risk factors for perioperative mortality using available demographic and clinical variables of interest. BASIC PROCEDURES: Retrospective descriptive analysis of premature infants (gestational age less than or equal to 36weeks) undergoing abdominal operations during the first 2 months of life using the American College of Surgeon's National Surgical Quality Improvement Project Pediatric (NSQIP-P, 2012-2015) database...
January 31, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29452808/norepinephrine-exerts-an-inotropic-effect-during-the-early-phase-of-human-septic-shock
#12
O Hamzaoui, M Jozwiak, T Geffriaud, B Sztrymf, D Prat, F Jacobs, X Monnet, P Trouiller, C Richard, J L Teboul
BACKGROUND: We conducted this study to investigate whether norepinephrine increases cardiac contractility when administered during the early phase of septic shock. METHODS: We studied 38 patients with septic shock who had been resuscitated for <3 h and whose mean arterial pressure (MAP) remained <65 mm Hg. Echocardiographic variables were obtained before (T 0 ) and after either initiation or an increase in the dose of a norepinephrine infusion to increase MAP to ≥ 65 mm Hg (T 1 )...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29444748/aortopulmonary-collaterals-in-neonates-with-d-transposition-of-the-great-arteries-clinical-significance-early-after-arterial-switch-operation
#13
Alexandra Wipf, Martin Christmann, Susanne Navarini-Meury, Hitendu Dave, Daniel Quandt, Walter Knirsch, Oliver Kretschmar
OBJECTIVES: Purpose of this study is to evaluate the clinical significance of major aortopulmonary collateral arteries (MAPCAs) during the early postoperative course after arterial switch operation (ASO) in d-transposition of the great arteries (dTGA). METHODS: Clinical data of 98 patients with simple dTGA between January 2007 and December 2016 at the University Children's Hospital Zurich, Switzerland were analyzed retrospectively. RESULTS: 37 from 98 patients (38%) required cardiac catheterization (CC) due to an early complicated postoperative course or difficult coronary transfer due to special coronary anatomy...
February 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29441350/perioperative-goal-directed-therapy-using-invasive-uncalibrated-pulse-contour-analysis
#14
Bernd Saugel, Daniel A Reuter
"Perioperative goal-directed therapy" (PGDT) aims at an optimization of basic and advanced global hemodynamic variables to maintain adequate oxygen delivery to the end-organs. PGDT protocols help to titrate fluids, vasopressors, or inotropes to hemodynamic target values. There is considerable evidence that PGDT can improve patient outcome in high-risk patients if both fluids and inotropes are administered to target hemodynamic variables reflecting blood flow. Despite this evidence, PGDT strategies aiming at an optimization of blood flow seem to be not well implemented in routine clinical care...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29439683/elevated-central-venous-pressure-is-associated-with-increased-mortality-in-pediatric-septic-shock-patients
#15
Seung Jun Choi, Eun-Ju Ha, Won Kyoung Jhang, Seong Jong Park
BACKGROUND: Central venous pressure (CVP) is an important factor affecting capillary blood flow, and it is associated with poor outcomes in adult septic shock patients. However, whether a similar association exists in pediatric patients remains unclear. METHODS: We retrospectively analyzed data from patients admitted to our pediatric intensive care unit (PICU) between February 2009 and July 2015. Patients were divided into two groups-survivors and nonsurvivors-according to 28-day mortality...
February 13, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29438568/haemodynamic-assessment-and-support-in-sepsis-and-septic-shock-in-resource-limited-settings
#16
David Misango, Rajyabardhan Pattnaik, Tim Baker, Martin W Dünser, Arjen M Dondorp, Marcus J Schultz
Background: Recommendations for haemodynamic assessment and support in sepsis and septic shock in resource-limited settings are largely lacking. Methods: A task force of six international experts in critical care medicine, all of them members of the Global Intensive Care Working Group of the European Society of Intensive Care Medicine and with extensive bedside experience in resource-limited intensive care units, reviewed the literature and provided recommendations regarding haemodynamic assessment and support, keeping aspects of efficacy and effectiveness, availability and feasibility and affordability and safety in mind...
February 9, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29437909/when-lightning-strikes-twice-in-pediatrics-case-report-and-review-of-recurrent-myocarditis
#17
Alisha Floyd, Ashwin Lal, Kimberly Molina, Michael Puchalski, Dylan Miller, Lindsay May
Myocarditis is an important but incompletely understood cause of cardiac dysfunction. Children with fulminant myocarditis often require inotropic or mechanical circulatory support, and researchers in some studies suggest that up to 42% of children who die suddenly have evidence of myocarditis. Recurrent myocarditis is extremely rare, and the vast majority of reported cases involve adult patients. Pediatric providers who suspect a recurrence of myocarditis have limited evidence to guide patient management because the literature in this domain is sparse...
February 8, 2018: Pediatrics
https://www.readbyqxmd.com/read/29437800/ventricular-tachyarrhythmia-in-a-78-year-old-woman-with-essential-thrombocythaemia
#18
Mary Rodriguez-Ziccardi, Manolo Rubio, Marvin Lu, Allan Greenspan
Anagrelide is a phosphodiesterase-3 inhibitor used in the treatment of essential thrombocythaemia. Cardiovascular side effects such as ventricular tachycardia and cardiomyopathy are rare but potentially fatal and should be made known to patients before starting the medication. It usually arises within the first 6 months after initiation of therapy and may be dose related. The elderly population are particularly susceptible. These cardiotoxicities result from an increase in cyclic AMP that induces positive inotropic and chronotropic effects and are often reversible with cessation of use...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29436789/evaluation-of-chronic-losartan-treatment-effect-on-cardiac-chronotropic-dysfunction-in-biliary-cirrhotic-rats
#19
Farahnaz Jazaeri, Razieh Afsharmoghaddam, Alireza Abdollahi, Giti Ghamami, Ahmad Reza Dehpour
Cirrhosis is associated with cardiac chronotropic and inotropic dysfunction which is known as cirrhotic cardiomyopathy. Cardiac responsiveness to adrenergic stimulation is impaired in cirrhosis. Moreover, there is vagal nerve dysfunction which is related to neuromodulatory dysfunction of the angiotensin II in the cirrhosis. This study was aimed to explore the hypothesis that administration of Losartan-angiotensin II receptor antagonist increases cardiac chronotropic response to isoproterenol in cirrhotic rats; and if so, whether this is associated with altered cardiac TGF-β receptor expression...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29436645/ouabain-suppresses-the-growth-and-migration-abilities-of-glioma-u%C3%A2-87mg-cells-through-inhibiting-the-akt-mtor-signaling-pathway-and-downregulating-the-expression-of-hif%C3%A2-1%C3%AE
#20
Xiao-Sa Yang, Zhong-Wei Xu, Tai-Long Yi, Rui-Cheng Xu, Jie Li, Wen-Bin Zhang, Sai Zhang, Hong-Tao Sun, Ze-Qi Yu, Hao-Xiang Xu, Yue Tu, Shi-Xiang Cheng
Glioma is one of the most malignant forms of brain tumor, and has been of persistent concern due to its high recurrence and mortality rates, and limited therapeutic options. As a cardiac glycoside, ouabain has widespread applications in congestive heart diseases due to its positive cardiac inotropic effect by inhibiting Na+/K+‑ATPase. Previous studies have demonstrated that ouabain has antitumor activity in several types of human tumor, including glioma. However, the exact underlying mechanism remains to be elucidated...
February 12, 2018: Molecular Medicine Reports
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