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https://www.readbyqxmd.com/read/29458085/the-effect-of-surface-charge-and-ph-on-the-physiological-behaviour-of-cobalt-copper-manganese-antimony-zinc-and-titanium-oxide-nanoparticles-in-vitro
#1
Tiina Titma
The precise knowledge on various interactions of metal nanoparticles (NP) in a living organism is scarce. It is expected that metals can bind to nucleic acids, peptides and proteins (e.g. enzymes), and modify the functioning of vital cellular compartments after entering the organism. The predictive factors for quantitative nanostructure-activity relationship (QNAR) analysis could enhance efficient and harmless usage of nanoparticles (NPs) in the industry as well in the medicine. The studies value the composition of the NP corona determined by time, temperature and source of protein which has been found to implicate the physiological behaviour of NPs...
February 16, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29457660/prevalence-of-orofacial-clefts-and-risks-for-nonsyndromic-cleft-lip-with-or-without-cleft-palate-in-newborns-at-a-university-hospital-from-west-mexico
#2
Jorge Román Corona-Rivera, Lucina Bobadilla-Morales, Alfredo Corona-Rivera, Christian Peña-Padilla, Sandra Olvera-Molina, Miriam A Orozco-Martín, Diana García-Cruz, Izabel M Ríos-Flores, Brian Gabriel Gómez-Rodríguez, Gemma Rivas-Soto, J Jesús Pérez-Molina
We determined the overall prevalence of typical orofacial clefts (OFCs) and the potential risks for nonsyndromic cleft lip with or without palate (NSCL±P) in a University Hospital from west México. For the prevalence, 227 live born infants with typical OFCs were included from a total of 81,193 births occurred during the period 2009 to 2016 at the 'Dr. Juan I. Menchaca' Civil Hospital of Guadalajara (Guadalajara, Jalisco, Mexico). To evaluate potential risks, a case-control study was conducted among 420 newborns, including only those 105 patients with NSCL±P (cases), and 315 infants without birth defects (controls)...
February 19, 2018: Congenital Anomalies
https://www.readbyqxmd.com/read/29456258/modifying-the-standard-disk-model-for-the-ultraviolet-spectral-analysis-of-disk-dominated-cataclysmic-variables-i-the-novalikes-mv-lyrae-bz-camelopardalis-and-v592-cassiopeiae
#3
Patrick Godon, Edward M Sion, Şölen Balman, William P Blair
The standard disk is often inadequate to model disk-dominated cataclysmic variables (CVs) and generates a spectrum that is bluer than the observed UV spectra. X-ray observations of these systems reveal an optically thin boundary layer (BL) expected to appear as an inner hole in the disk. Consequently, we truncate the inner disk. However, instead of removing the inner disk, we impose the no-shear boundary condition at the truncation radius, thereby lowering the disk temperature and generating a spectrum that better fits the UV data...
September 1, 2017: Astrophysical Journal
https://www.readbyqxmd.com/read/29455921/clinical-and-epidemiological-characteristics-of-intestinal-parasite-infection-by-blastocystis-hominis
#4
C Ocaña-Losada, J A Cuenca-Gómez, M T Cabezas-Fernández, J Vázquez-Villegas, M J Soriano-Pérez, I Cabeza-Barrera, J Salas-Coronas
OBJECTIVES: Blastocystis hominis (B. hominis) is one of the most common intestinal parasites isolated in humans. The parasite can cause gastrointestinal symptoms or, in most cases, remain asymptomatic. There are issues concerning the parasite's pathogenic character. The aim of this study was to analyse the clinical and epidemiological characteristics of the parasite infection by B. hominis, with or without other parasitic co-infections. PATIENTS AND METHODS: An observational retrospective study was conducted of B...
February 15, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29453539/nanoparticle-protein-interaction-the-significance-and-role-of-protein-corona
#5
Saad Mohammad Ahsan, Chintalagiri Mohan Rao, Md Faiz Ahmad
The physico-chemical properties of nanoparticles, as characterized under idealized laboratory conditions, have been suggested to differ significantly when studied under complex physiological environments. A major reason for this variation has been the adsorption of biomolecules (mainly proteins) on the nanoparticle surface, constituting the so-called "biomolecular corona". The formation of biomolecular corona on the nanoparticle surface has been reported to influence various nanoparticle properties viz...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29450412/clinically-approved-liposomal-nanomedicines-lessons-learned-from-the-biomolecular-corona
#6
Giulio Caracciolo
Nowadays, liposomes are the most successful drug delivery systems with a dozen drug products available in the clinic. Grafting poly-(ethylene glycol) (PEG) onto the liposome surface prevents protein binding thus prolonging blood circulation, while synthetic modification of the terminal PEG molecule with ligands (e.g. monoclonal antibodies and peptides) should promote selective accumulation in the tumor region with respect to healthy tissues. However, despite big efforts, advances have not outgrown the development stage and just a few targeted liposomal drugs are commercially available...
February 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29449655/observationally-quantified-reconnection-providing-a-viable-mechanism-for-active-region-coronal-heating
#7
Kai E Yang, Dana W Longcope, M D Ding, Yang Guo
The heating of the Sun's corona has been explained by several different mechanisms including wave dissipation and magnetic reconnection. While both have been shown capable of supplying the requisite power, neither has been used in a quantitative model of observations fed by measured inputs. Here we show that impulsive reconnection is capable of producing an active region corona agreeing both qualitatively and quantitatively with extreme-ultraviolet observations. We calculate the heating power proportional to the velocity difference between magnetic footpoints and the photospheric plasma, called the non-ideal velocity...
February 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29439415/current-application-of-capillary-electrophoresis-in-nanomaterial-characterisation-and-its-potential-to-characterise-the-protein-and-small-molecule-corona
#8
REVIEW
Andrew J Chetwynd, Emily J Guggenheim, Sophie M Briffa, James A Thorn, Iseult Lynch, Eugenia Valsami-Jones
Due to the increasing use and production of nanomaterials (NMs), the ability to characterise their physical/chemical properties quickly and reliably has never been so important. Proper characterisation allows a thorough understanding of the material and its stability, and is critical to establishing dose-response curves to ascertain risks to human and environmental health. Traditionally, methods such as Transmission Electron Microscopy (TEM), Field Flow Fractionation (FFF) and Dynamic Light Scattering (DLS) have been favoured for size characterisation, due to their wide-availability and well-established protocols...
February 10, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29434675/best-practice-in-the-management-of-storage-symptoms-in-male-lower-urinary-tract-symptoms-a-review-of-the-evidence-base
#9
REVIEW
Mauro Gacci, Arcangelo Sebastianelli, Pietro Spatafora, Giovanni Corona, Sergio Serni, Dirk De Ridder, Stavros Gravas, Paul Abrams
Storage lower urinary tract symptoms (LUTS) are characterized by an altered bladder sensation, increased daytime frequency, nocturia, urgency and urgency incontinence. Some evidence underlines the role of metabolic factors, pelvic ischemia, prostatic chronic inflammation and associated comorbidities in the pathophysiology of storage LUTS. A detailed evaluation of the severity of storage LUTS, and the concomitance of these symptoms with voiding and postmicturition symptoms, is mandatory for improving the diagnosis and personalizing treatment...
February 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29433203/physicochemical-and-nutraceutical-properties-of-moringa-moringa-oleifera-leaves-and-their-effects-in-an-in-vivo-aom-dss-induced-colorectal-carcinogenesis-model
#10
M L Cuellar-Nuñez, I Luzardo-Ocampo, R Campos-Vega, M A Gallegos-Corona, E González de Mejía, G Loarca-Piña
Moringa (Moringa oleifera) is a plant that has generated great interest in recent years because of its attributed medicinal properties. The aim of this study was to characterize the bioactive compounds of moringa leaves (MO) and evaluate their effect on a colorectal carcinogenesis model. Twenty-four male CD-1 mice were divided into 4 groups: Group 1 fed with basal diet (negative control/NC); Group 2 received AOM/DSS (positive control); Groups 3 and 4 were fed with basal diet supplemented with moringa leaves (2...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29432444/agreement-between-self-reported-and-physically-verified-male-circumcision-status-in-nyanza-region-kenya-evidence-from-the-tasco-study
#11
Elijah Odoyo-June, Kawango Agot, Edward Mboya, Jonathan Grund, Paul Musingila, Donath Emusu, Leonard Soo, Boaz Otieno-Nyunya
BACKGROUND: Self-reported male circumcision (MC) status is widely used to estimate community prevalence of circumcision, although its accuracy varies in different settings depending on the extent of misreporting. Despite this challenge, self-reported MC status remains essential because it is the most feasible method of collecting MC status data in community surveys. Therefore, its accuracy is an important determinant of the reliability of MC prevalence estimates based on such surveys...
2018: PloS One
https://www.readbyqxmd.com/read/29430025/reconnection-driven-magnetohydrodynamic-turbulence-in-a-simulated-coronal-hole-jet
#12
Vadim M Uritsky, Merrill A Roberts, C Richard DeVore, Judith T Karpen
Extreme-ultraviolet and X-ray jets occur frequently in magnetically open coronal holes on the Sun, especially at high solar latitudes. Some of these jets are observed by white-light coronagraphs as they propagate through the outer corona toward the inner heliosphere, and it has been proposed that they give rise to microstreams and torsional Alfvén waves detected in situ in the solar wind. To predict and understand the signatures of coronal-hole jets, we have performed a detailed statistical analysis of such a jet simulated with an adaptively refined magnetohydrodynamics model...
March 10, 2017: Astrophysical Journal
https://www.readbyqxmd.com/read/29428702/micromechanics-of-brain-white-matter-tissue-a-fiber-reinforced-hyperelastic-model-using-embedded-element-technique
#13
Seyed Abdolmajid Yousefsani, Amir Shamloo, Farzam Farahmand
A transverse-plane hyperelastic micromechanical model of brain white matter tissue was developed using the embedded element technique (EET). The model consisted of a histology-informed probabilistic distribution of axonal fibers embedded within an extracellular matrix, both described using the generalized Ogden hyperelastic material model. A correcting method, based on the strain energy density function, was formulated to resolve the stiffness redundancy problem of the EET in large deformation regime. The model was then used to predict the homogenized tissue behavior and the associated localized responses of the axonal fibers under quasi-static, transverse, large deformations...
February 3, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29427597/insights-into-the-homo-oligomerization-properties-of-n-terminal-coiled-coil-domain-of-ebola-virus-vp35-protein
#14
Venkata Krishnan Ramaswamy, Francesco Di Palma, Attilio V Vargiu, Angela Corona, Dario Piano, Paolo Ruggerone, Luca Zinzula, Enzo Tramontano
The multifunctional Ebola virus (EBOV) VP35 protein is a key determinant of virulence. VP35 is essential for EBOV replication, is a component of the viral RNA polymerase and participates in nucleocapsid formation. Furthermore, VP35 contributes to EBOV evasion of the host innate immune response by suppressing RNA silencing and blocking RIG-I like receptors' pathways that lead to type I interferon (IFN) production. VP35 homo-oligomerization has been reported to be critical for its replicative function and to increase its IFN-antagonism properties...
February 7, 2018: Virus Research
https://www.readbyqxmd.com/read/29427244/anthelmintic-efficacy-of-hydro-methanolic-extracts-of-larrea-tridentata-against-larvae-of-haemonchus-contortus
#15
José E García, Leónides Gómez, Pedro Mendoza-de-Gives, José L Rivera-Corona, Jair Millán-Orozco, Juan A Ascacio, Miguel A Medina, Miguel Mellado
An in vitro study was conducted to determine the anthelminthic activity of hydro-methanolic extracts of Larrea tridentata on sheathed and exsheathed larvae of Haemonchus contortus. Larvae of the parasite were incubated at 20-25 °C in hydro-methanolic extracts at concentrations of 12.5, 25, 50, 100, and 200 mg/mL for 24, 48, or 72 h. Ivermectin and water were the positive and negative controls, respectively. Total phenolic compounds of leaves of L. tridentata were 97.88 ± 10.45 mg/g of dry matter. Other compounds detected in this shrub by HPLC-mass spectrometry were sesamin, galocatechin, peonidin 3-O rutinoside, methyl galangin, epigallocatechin 7-O-glucuronide, and epigalocatechin...
February 9, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29426649/rest-and-stress-longitudinal-systolic-left-ventricular-mechanics-in-hypertrophic-cardiomyopathy-implications-for-prognostication
#16
Iraklis Pozios, Aurelio Pinheiro, Celia Corona-Villalobos, Lars L Sorensen, Zeina Dardari, Hong-Yun Liu, Kenneth Cresswell, Susan Phillip, David A Bluemke, Stefan L Zimmerman, M Roselle Abraham, Theodore P Abraham
BACKGROUND: Exercise intolerance is the most common symptom in hypertrophic cardiomyopathy (HCM). We examined whether inability to augment myocardial mechanics during exercise would influence functional performance and clinical outcomes in HCM. METHODS: Ninety-five HCM patients (32 nonobstructive, 32 labile-obstructive, 31 obstructive) and 26 controls of similar age and gender distribution were recruited prospectively. They underwent rest and treadmill stress strain echocardiography, and 61 of them underwent magnetic resonance imaging...
February 6, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29425940/rehabilitation-course-and-specification-of-dysmetria-of-a-patient-with-ataxia-dysmetria-and-hemiparesis-following-a-stroke-in-the-corona-radiata-a-case-presentation
#17
Monir Mohar, Kosandra Hartman, Bronwyn Long, Peter Lee, Adrian Didita, Eric L Altschuler
We present a case of a patient with ataxia, dysmetria and hemiparesis following a stroke in the corona radiata. The patient had an excellent clinical course with near resolution of symptoms in two and a half weeks, and returned and back to work fully duty and full-time a couple of weeks later. We use a video of severeal neurological tests to demonstrate and characterize the dysmetria. Interestingly, a key characteristic of the dysmetria appears to be different from that seen in patients with dysmetria arising from a cerebellar, thalamic or pontine lesion...
February 6, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29422445/septic-arthritis-caused-by-granulicatella-adiacens-after-anterior-cruciate-ligament-reconstruction
#18
A Mena Rosón, H Valencia García, F J Moreno Coronas
Septic arthritis after knee arthroscopy is an extremely rare condition. A rate of 0.15-0.84% cases of postoperative infection is estimated in several series. The arthroscopy procedure most frequently related with an infectious complication is anterior cruciate ligament (ACL) reconstruction, with a prevalence of 0.3-1.7% cases. Staphylococcus sp. is the pathogen most commonly cultured. We describe a case of septic arthritis after ACL reconstruction. We found no published case of septic arthritis caused by this microorganism after knee arthroscopy...
February 5, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29420473/magnetic-cage-and-rope-as-the-key-for-solar-eruptions
#19
Tahar Amari, Aurélien Canou, Jean-Jacques Aly, Francois Delyon, Fréderic Alauzet
Solar flares are spectacular coronal events that release large amounts of energy. They are classified as either eruptive or confined, depending on whether they are associated with a coronal mass ejection. Two types of model have been developed to identify the mechanism that triggers confined flares, although it has hitherto not been possible to decide between them because the magnetic field at the origin of the flares could not be determined with the required accuracy. In the first type of model, the triggering is related to the topological complexity of the flaring structure, which implies the presence of magnetically singular surfaces...
February 7, 2018: Nature
https://www.readbyqxmd.com/read/29417159/-digital-volume-tomography-dedicated-scanner-and-cone-beam-ct-with-c%C3%A2-arm-systems
#20
REVIEW
M Fiebich, D Weber
CLINICAL/METHODICAL ISSUE: Digital volume tomography (DVT) and cone-beam computed tomography (CT) with C‑arm systems have become established three-dimensional imaging systems as an alternative to CT in some application areas. STANDARD RADIOLOGICAL METHODS: The technology of the systems is well developed so that they have become a competing method to CT imaging in terms of image quality and radiation exposure. PERFORMANCE: An advantage is the better spatial resolution, preferably with dedicated scanner systems, especially in the z direction...
February 7, 2018: Der Radiologe
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