keyword
MENU ▼
Read by QxMD icon Read
search

Corona

keyword
https://www.readbyqxmd.com/read/29676567/biomolecular-corona-dictates-a%C3%AE-fibrillation-process
#1
Alireza Lotfabadi, Mohammad Javad Hajipour, Hossein Derakhshankhah, Afshin Peirovi, Samaneh Saffar, Elnaz Shams, Elnaz Fatemi, Ebrahim Barzegari, Sajad Sarvari, Faezeh Moakedi, Maryam Ferdousi, Fatemeh Atyabi, Ali Akbar Saboury, Rassoul Dinarvand
Amyloid beta (Aβ), which forms toxic oligomers and fibrils in brain tissues of patients with Alzheimer's disease, is broadly used as a model protein to probe the effect of nanoparticles (NPs) on oligomerization and fibrillation process. However, majority of the reports in the field, ignored the effect of biomolecular corona on the fibrillogenesis of the Aβ proteins. Biomolecular corona, which is a layer composed of various types of biomolecules that covers surface of NPs upon their interaction with biological fluids, determines the biological fates of NPs...
April 20, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29675210/dynamical-inversion-of-the-energy-landscape-promotes-non-equilibrium-self-assembly-of-binary-mixtures
#2
Luis Ruiz Pestana, Natalie Minnetian, Laura Nielsen Lammers, Teresa Head-Gordon
When driven out of equilibrium, many diverse systems can form complex spatial and dynamical patterns, even in the absence of attractive interactions. Using kinetic Monte Carlo simulations, we investigate the phase behavior of a binary system of particles of dissimilar size confined between semiflexible planar surfaces, in which the nanoconfinement introduces a non-local coupling between particles, which we model as an activation energy barrier to diffusion that decreases with the local fraction of the larger particle...
February 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674566/erratum-for-the-report-a-precise-measurement-of-the-magnetic-field-in-the-corona-of-the-black-hole-binary-v404-cygni-by-y-dallilar-s-s-eikenberry-a-garner-r-d-stelter-a-gottlieb-p-gandhi-p-casella-v-s-dhillon-t-r-marsh-s-p-littlefair-l-hardy-r-fender-k-mooley
#3
https://www.readbyqxmd.com/read/29674266/effects-of-high-protein-diet-containing-isolated-whey-protein-in-rats-submitted-to-resistance-training-of-aquatic-jumps
#4
Eudes Thiago Pereira Avila, Thiago da Rosa Lima, Ramires Alsamir Tibana, Paula Caroline de Almeida, Géssica Alves Fraga, Mariana de Souza Sena, Luiz Felipe Petusk Corona, James Wilfred Navalta, Sajjad Rezaei, Morteza Ghayomzadeh, Amílcar Sabino Damazo, Jonato Prestes, Fabrício Azevedo Voltarelli
OBJECTIVES: Isolated whey protein (IWP) can decrease body fat compared with other protein sources. The present study verified the effects of high protein diet (HD) containing IWP on several parameters of rats subjected to resistance training (RT). METHODS: Thirty-two male Wistar rats (60 days of age) were separated into four groups (n = 8/group): sedentary normoproteic (IWP 14%; SN); sedentary hyperproteic (IWP 35%; SH); trained normoproteic (IWP 14%; TN), and trained hyperproteic (WPI 35%; TH)...
February 13, 2018: Nutrition
https://www.readbyqxmd.com/read/29673307/the-pathology-of-wobbly-hedgehog-syndrome
#5
Josué Díaz-Delgado, Derick B Whitley, Ralph W Storts, Jill J Heatley, Sharman Hoppes, Brian F Porter
Wobbly hedgehog syndrome (WHS) is a leading cause of neurologic disease in African pygmy hedgehogs (APHs; Atelerix albiventris). This study describes the signalment, clinical signs, gross, microscopic, and ultrastructural lesions of WHS in a cohort of 12 pet APHs. Microscopically, lesions consisted of status spongiosus of the white matter, typically bilateral and symmetrical, with myelin degeneration and loss that was accompanied by neuronal/axonal degeneration plus reactive microgliosis and mild, focal astrocytosis and astrogliosis...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29670571/electromyographical-gait-characteristics-in-parkinson-s-disease-effects-of-combined-physical-therapy-and-rhythmic-auditory-stimulation
#6
Christopher A Bailey, Federica Corona, Mauro Murgia, Roberta Pili, Massimiliano Pau, Julie N Côté
Background: In persons with Parkinson's disease (PD), gait dysfunctions are often associated with abnormal neuromuscular function. Physical therapy combined with auditory stimulation has been recently shown to improve motor function and gait kinematic patterns; however, the underlying neuromuscular control patterns leading to this improvement have never been identified. Objectives: (1) Assess the relationships between motor dysfunction and lower limb muscle activity during gait in persons with PD; (2) Quantify the effects of physical therapy with rhythmic auditory stimulation (PT-RAS) on lower limb muscle activity during gait in persons with PD...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29668613/brain-mapping-for-long-term-recovery-of-gait-after-supratentorial-stroke-a-retrospective-cross-sectional-study
#7
Dae Hyun Kim, Sunghyon Kyeong, Kyung Hee Do, Seong Kyu Lim, Hyong Keun Cho, Suk Jung, Hye Won Kim
The recovery of independent gait after stroke is a main goal of patients and understanding the relationship between brain lesions and the recovery of gait can help physicians set viable rehabilitation plans. Our study investigated the association between variables of gait parameters and brain lesions.Fifty poststroke patients with a mean age of 67.5 ± 1.3 years and an average duration after onset of 62.2 ± 7.9 months were included. Three-dimensional gait analysis and magnetic resonance imaging were conducted for all patients...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668268/microfluidic-examination-of-the-hard-biomolecular-corona-formed-on-engineered-particles-in-different-biological-milieu
#8
Alessia C G Weiss, Kristian Kempe, Stephan Förster, Frank Caruso
The formation of a biomolecular corona around engineered particles determines, in large part, their biological behavior in vitro and in vivo. To gain a fundamental understanding of how particle design and the biological milieu influence the formation of the "hard" biomolecular corona, we conduct a series of in vitro studies using microfluidics. This setup allows the generation of a dynamic incubation environment with precise control over the applied flow rate, stream orientation, and channel dimensions, thus allowing accurate control of the fluid flow and the shear applied to the proteins and particles...
April 18, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29668255/differential-recognition-of-nanoparticle-protein-corona-and-modified-low-density-lipoprotein-by-macrophage-receptor-with-collagenous-structure
#9
Sandra Lara, André Perez-Potti, Luciana M Herda, Laurent Adumeau, Kenneth A Dawson, Yan Yan
Key practical challenges such as to understand the immunological processes at the nanoscale, and to control the targeting and accumulation of nano-objects in vivo now further stimulate efforts to underpin phenomenological knowledge of the nanoscale with more mechanistic and molecular insight. Thus, the question as to what constitutes nanoscale biological identity continues to evolve. Certainly nanoparticles in contact with complex biological milieu develop a biological identity, differing from the original nanomaterial, now referred to as the 'biomolecular corona'...
April 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29665292/double-targeting-explosible-nanofirework-for-tumor-ignition-to-guide-tumor-depth-photothermal-therapy
#10
Ming-Kang Zhang, Xiao-Gang Wang, Jing-Yi Zhu, Miao-Deng Liu, Chu-Xin Li, Jun Feng, Xian-Zheng Zhang
This study reports a double-targeting "nanofirework" for tumor-ignited imaging to guide effective tumor-depth photothermal therapy (PTT). Typically, ≈30 nm upconversion nanoparticles (UCNP) are enveloped with a hybrid corona composed of ≈4 nm CuS tethered hyaluronic acid (CuS-HA). The HA corona provides active tumor-targeted functionality together with excellent stability and improved biocompatibility. The dimension of UCNP@CuS-HA is specifically set within the optimal size window for passive tumor-targeting effect, demonstrating significant contributions to both the in vivo prolonged circulation duration and the enhanced size-dependent tumor accumulation compared with ultrasmall CuS nanoparticles...
April 17, 2018: Small
https://www.readbyqxmd.com/read/29664641/simulations-study-of-single-component-and-mixed-n-alkyl-peg-micelles
#11
Maisa Vuorte, Jukka Määttä, Maria Sammalkorpi
Here, we study one component and mixed n-alkyl-poly(ethylene oxide) (Cm En ) micelles with varying poly(ethylene oxide) (PEG) chain lengths n using coarse-grained molecular simulations. These non-ionic alkyl-PEG surfactants and their aggregates are widely used in bio and chemical technology. As expected, the simulations show that increasing the PEG chain length decreases the alkyl-PEG micelle core diameter and aggregation number but also enhances PEG chain penetration to the core region and spreads the micelle corona...
April 17, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29664607/polyserotonin-nanoparticles-as-multifunctional-materials-for-biomedical-applications
#12
Nako Nakatsuka, Mohammad Mahdi Hasani-Sadrabadi, Kevin M Cheung, Thomas D Young, Ghasem Bahlakeh, Alireza Moshaverinia, Paul S Weiss, Anne M Andrews
Serotonin-based nanoparticles represent a class of previously unexplored multifunctional nanoplatforms with potential biomedical applications. Serotonin, under basic conditions, self-assembles into monodisperse nanoparticles via autoxidation of serotonin monomers. To demonstrate potential applications of polyserotonin nanoparticles for cancer therapeutics, we show that these particles are biocompatible, exhibit photothermal effects when exposed to near-infrared radiation, and load the chemotherapeutic drug doxorubicin releasing it contextually and responsively in specific microenvironments...
April 17, 2018: ACS Nano
https://www.readbyqxmd.com/read/29664178/hypothyroidism-impairs-somatovisceral-reflexes-involved-in-micturition-of-female-rabbits
#13
Octavio Sánchez-García, Rhode López-Juárez, Julia Rodríguez-Castelán, Dora L Corona-Quintanilla, Margarita Martínez-Gómez, Estela Cuevas-Romero, Francisco Castelán
AIMS: To determine the impact of hypothyroidism on the bladder and urethral functions as well as in the activation of the pubococcygeous (Pcm) and bulbospongiosus (Bsm) during micturition. METHODS: Age-matched control and methimazole-induced hypothyroid female rabbits were used to simultaneously record cystometrograms, urethral pressure, and the reflex activation of Pcm and Bsm during the induced micturition. Urodynamic and urethral variables were measured. Activation or no activation of the Pcm and Bsm during the storage and voiding phases of micturition were categorized as 1 or 0...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29660714/techno-environmental-assessment-of-the-green-biorefinery-concept-combining-process-simulation-and-life-cycle-assessment-at-an-early-design-stage
#14
Andrea Corona, Morten Ambye-Jensen, Giovanna Croxatto Vega, Michael Zwicky Hauschild, Morten Birkved
The Green biorefinery (GBR) is a biorefinery concept that converts fresh biomass into value-added products. The present study combines a Process Flowsheet Simulation (PFS) and Life Cycle Assessment (LCA) to evaluate the technical and environmental performance of different GBR configurations and the cascading utilization of the GBR output. The GBR configurations considered in this study, test alternatives in the three main steps of green-biorefining: fractionation, precipitation, and protein separation. The different cascade utilization alternatives analyse different options for press-pulp utilization, and the LCA results show that the environmental profile of the GBR is highly affected by the utilization of the press-pulp and thus by the choice of conventional product replaced by the press-pulp...
April 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29660514/early-life-predictors-of-brain-development-at-term-equivalent-age-in-infants-born-across-the-gestational-age-spectrum
#15
REVIEW
Deanne K Thompson, Claire E Kelly, Jian Chen, Richard Beare, Bonnie Alexander, Marc L Seal, Katherine Lee, Lillian G Matthews, Peter J Anderson, Lex W Doyle, Alicia J Spittle, Jeanie L Y Cheong
BACKGROUND: It is well established that preterm infants have altered brain development compared with full-term (FT; ≥37 weeks' gestational age [GA]) infants, however the perinatal factors associated with brain development in preterm infants have not been fully elucidated. In particular, perinatal predictors of brain development may differ between very preterm infants (VP; <32 weeks' GA) and infants born moderate (MP; 32-33 weeks' GA) and late (LP; 34-36 weeks' GA) preterm, but this has not been studied...
April 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29660271/denaturation-via-surfactants-changes-composition-of-protein-corona
#16
Julius Mueller, Johanna Simon, Philipp Rohne, Claudia Koch-Brandt, Volker Mailaender, Svenja Morsbach, Katharina Landfester
The use of nanocarriers as drug delivery vehicles brings them into contact with blood plasma proteins. Polymeric nanocarriers require some sort of surfactant to ensure colloidal stability. Formation of the protein corona is therefore not only determined by the intrinsic properties of the nanocarrier itself, but also by the accompanying surfactant. Although it is well known that surfactants have an impact on protein structure, only few studies were conducted on the specific effect of surfactants on the composition of protein corona of nanocarriers...
April 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29658020/human-plasma-proteome-association-and-cytotoxicity-of-nano-graphene-oxide-grafted-with-stealth-polyethylene-glycol-and-poly-2-ethyl-2-oxazoline
#17
Miaoyi Wang, Ove J R Gustafsson, Ghizal Siddiqui, Ibrahim Javed, Hannah G Kelly, Thomas Blin, Hong Yin, Stephen J Kent, Darren J Creek, Kristian Kempe, Pu Chun Ke, Thomas P Davis
Polyethylene glycol (PEG) is a gold standard against protein fouling. However, recent studies have revealed surprising adverse effects of PEG, namely its immunogenicity and shortened bio-circulation upon repeated dosing. This highlights a crucial need to further examine 'stealth' polymers for controlling the protein 'corona', a new challenge in nanomedicine and bionanotechnology. Poly(2-ethyl-2-oxazoline) (PEtOx) is another primary form of stealth polymer that, despite its excellent hydrophilicity and biocompatibility, has found considerably less applications compared with PEG...
April 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29657703/determining-the-elemental-and-isotopic-composition-of-the-presolar-nebula-from-genesis-data-analysis-the-case-of-oxygen
#18
J Martin Laming, V S Heber, D S Burnett, Y Guan, R Hervig, G R Huss, A J G Jurewicz, E C Koeman-Shields, K D McKeegan, L Nittler, D B Reisenfeld, K D Rieck, J Wang, R C Wiens, D S Woolum
We compare element and isotopic fractionations measured in solar wind samples collected by NASA's Genesis mission with those predicted from models incorporating both the ponderomotive force in the chromosphere and conservation of the first adiabatic invariant in the low corona. Generally good agreement is found, suggesting that these factors are consistent with the process of solar wind fractionation. Based on bulk wind measurements, we also consider in more detail the isotopic and elemental abundances of O...
December 10, 2017: Astrophysical Journal. Letters
https://www.readbyqxmd.com/read/29656205/a-nano-bio-interfacial-protein-corona-on-silica-nanoparticle
#19
Hongyan Zhang, Jiaxi Peng, Xin Li, Shengju Liu, Zhengyan Hu, Guiju Xu, Ren'an Wu
Nano-bio interaction takes the crucial role in bio-application of nanoparticles. The systematic mapping of interfacial proteins remains the big challenge as low level of proteins within interface regions and lack of appropriate technology. Here, a facile proteomic strategy was developed to characterize the interfacial protein corona (noted as IPC) that has strong interactions with silica nanoparticle, via the combination of the vigorous elution with high concentration sodium dodecyl sulfate (SDS) and the pre-isolation of sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)...
April 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29656047/the-complex-association-between-metabolic-syndrome-and-male-hypogonadism
#20
Christina Dimopoulou, Dimitrios G Goulis, Giovanni Corona, Mario Maggi
BACKGROUND: The complex association between metabolic syndrome (MetS) and male hypogonadism is well established. A number of observational studies show that low testosterone is associated with insulin resistance and an increased risk for diabetes mellitus and MetS in men. AIMS: To elucidate the association between MetS and male hypogonadism, present epidemiological data on the co-existence of the two comorbidities, enlighten the underlying pathophysiology and appraise the effects of testosterone supplementation therapy (TTh) and lifestyle modifications on MetS and body composition in men...
April 12, 2018: Metabolism: Clinical and Experimental
keyword
keyword
3395
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"