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Stephen M Goldman, Benjamin T Corona
Minced muscle grafts (MG) promote de novo muscle fiber regeneration and neuromuscular strength recovery in small and large animal models of volumetric muscle loss. The most noteworthy limitation of this approach is its reliance on a finite supply of donor tissue. To address this shortcoming, this study sought to evaluate micronized acellular urinary bladder matrix (UBM) as a scaffolding to promote in vivo expansion of this MG therapy in a rat model. Rats received volumetric muscle loss injuries to the tibialis anterior muscle of their left hind limb which were either left untreated or repaired with minced muscle graft at dosages of 50% and 100% of the defect mass, urinary bladder matrix in isolation, or a with an expansion product consisting of a combination of the two putative therapies in which the minced graft is delivered at a dosage of 50% of the defect mass...
2017: PloS One
Teresa Corona, Sandeep K Padamati, Ferran Acuña-Parés, Carole Duboc, Wesley R Browne, Anna Company
The formation and spectroscopic characterization of a superoxido cobalt(iii) and a peroxido dicobalt(iii) species formed in the temperature dependent reversible reaction of a cobalt(ii) precursor with O2 is described. The electronic nature of each species is explored in their reactivity with organic substrates.
October 16, 2017: Chemical Communications: Chem Comm
Foteini Christidi, Efstratios Karavasilis, Panagiotis Ferentinos, Sophia Xirou, Georgios Velonakis, Michalis Rentzos, Vasiliki Zouvelou, Ioannis Zalonis, Efstathios Efstathopoulos, Nikolaos Kelekis, Ioannis Evdokimidis
OBJECTIVE: Pathological laughing and crying (PLC) is common in several neurological and psychiatric diseases and is associated with a distributed network involving the frontal cortex, the brainstem and cortico-pontine-cerebellar circuits. By applying multimodal neuroimaging approach, we examined the neuroanatomical substrate of PLC in a sample of patients with amyotrophic lateral sclerosis (ALS). METHODS: We studied 56 non-demented ALS patients and 25 healthy controls (HC)...
October 15, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Ting Shi, Yaping Zheng, Tianyu Wang, Peipei Li, Yudeng Wang, Dongdong Yao
Porous liquid is a kind of burgeoning material that possesses huge potential in gas separation and gas adsorption. Pore size has a dramatic influence on the gas adsorption of porous liquids. In this article, we chose hollow silica nanoparticles as cores, 3-(trihydroxysilyl)-1-propanesulfonic acid (SIT) as corona and cheap industrial reagent polyether amine (M2070) as canopy to obtain a new type of porous liquid. Hollow silica nanospheres with different pore sizes were chosen to investigate the influence of porosity size on CO2 adsorption capacity of porous liquids...
October 15, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Marcin Jankiewicz, Martha J Holmes, Paul A Taylor, Mark F Cotton, Barbara Laughton, André J W van der Kouwe, Ernesta M Meintjes
Background: Due to changes in guidelines and access to treatment, more children start combination antiretroviral therapy (ART) in infancy. With few studies examining the long-term effects of perinatal HIV infection and early ART on neurodevelopment, much is still unknown about brain maturation in the presence of HIV and ART. Follow-up studies of HIV infected (HIV+) children are important for monitoring brain development in the presence of HIV infection and ART. Methods: We use diffusion tensor imaging (DTI) to examine white matter (WM) in 65 HIV+ and 46 control (HIV exposed uninfected (HEU) and HIV unexposed uninfected (HU)) 7-year-old children...
2017: Frontiers in Neuroanatomy
Xianjiang Li, Wen Ma, Hongmei Li, Wanpeng Ai, Yu Bai, Huwei Liu
Ambient mass spectrometry provides great convenience for fast screening, and has showed promising potential in analytical chemistry. However, its relatively low sensitivity seriously restricts its practical utility in trace compound analysis. In this review, we summarize the sampling and analyte enrichment strategies coupled with nine modes of representative ambient mass spectrometry (desorption electrospray ionization, paper vhspray ionization, wooden-tip spray ionization, probe electrospray ionization, coated blade spray ionization, direct analysis in real time, desorption corona beam ionization, dielectric barrier discharge ionization, and atmospheric-pressure solids analysis probe) that have dramatically increased the detection sensitivity...
October 13, 2017: Analytical and Bioanalytical Chemistry
Sarah M Greising, Jessica C Rivera, Stephen M Goldman, Alain Watts, Carlos A Aguilar, Benjamin T Corona
Volumetric muscle loss (VML) resulting from extremity trauma presents chronic and persistent functional deficits which ultimately manifest disability. Acellular biological scaffolds, or decellularized extracellular matrices (ECMs), embody an ideal treatment platform due to their current clinical use for soft tissue repair, off-the-shelf availability, and zero autogenous donor tissue burden. ECMs have been reported to promote functional skeletal muscle tissue remodeling in small and large animal models of VML injury, and this conclusion was reached in a recent clinical trial that enrolled 13 patients...
October 13, 2017: Scientific Reports
Guoyong Zhou, Hong Xiao, Xiaoxia Li, Yi Huang, Wei Song, Liang Song, Meiwan Chen, Du Cheng, Xintao Shuai
A pH-sensitive copolymer PAsp(DIP)-b-PAsp(MEA) (PDPM) was synthesized and self-assembled to micelle loading chemotherapeutic drug doxorubicin (DOX) and introducing a gold nanocage structure for photothermo-chemotherapy and photoacoustic imaging. After further surface modification with polyethylene glycol (PEG), the DOX-loaded pH-sensitive gold nanocage (D-PGNC) around 100 nm possessed a uniform spherical structure with a pH-sensitive core of PAsp(DIP) incorporating DOX, an interlayer crosslinked via disulfide bonds and decorated with discontinuous gold shell, and a PEG corona...
October 10, 2017: Acta Biomaterialia
Manuel Y Schar, Giulia Corona, Gulten Soycan, Clemence Dine, Angelika Kristek, Sarah N S Alsharif, Volker Behrends, Alison Lovegrove, Peter R Shewry, Jeremy P E Spencer
SCOPE: Wholegrain has been associated with reduced chronic disease mortality, with oat intake particularly notable for lowering blood cholesterol and glycemia. To better understand the complex nutrient profile of oats, we studied urinary excretion of phenolic acids and avenanthramides after ingestion of oat bran in humans. METHODS AND RESULTS: After a 2d (poly)phenol-low diet, 7 healthy men provided urine 12h before, and 48h after, consuming 60g oat bran (7.8μmol avenanthramides, 139...
October 11, 2017: Molecular Nutrition & Food Research
Jesus Pujol, Laura Blanco-Hinojo, Ramón Coronas, Susanna Esteba-Castillo, Mercedes Rigla, Gerard Martínez-Vilavella, Joan Deus, Ramón Novell, Assumpta Caixàs
Warning signals indicating that a food is potentially dangerous may evoke a response that is not limited to the feeling of disgust. We investigated the sequence of brain events in response to visual representations of disgusting food using a dynamic image analysis. Functional MRI was acquired in 30 healthy subjects while they were watching a movie showing disgusting food scenes interspersed with the scenes of appetizing food. Imaging analysis included the identification of the global brain response and the generation of frame-by-frame activation maps at the temporal resolution of 2 s...
October 11, 2017: Human Brain Mapping
Priya S R Naidu, Marck Norret, Nicole M Smith, Sarah A Dunlop, Nicolas L Taylor, Melinda Fitzgerald, K Swaminathan Iyer
Composition of the protein corona formed on poly(ethylene glycol)-functionalised (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for 'stealth' functionality, we demonstrate preferential enrichment of specific serum proteins of varied biological functions in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona...
October 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Tian-Xu Zhang, Guan-Yin Zhu, Bo-Yao Lu, Chao-Liang Zhang, Qiang Peng
AIM: A comprehensive understanding of nanoparticle (NP)-protein interaction (protein corona formation) is required. So far, many factors influencing this interaction have been investigated, like size and ζ potential. However, NPs exposure concentration has always been ignored. Herein, we aim to disclose the correlation of NPs exposure concentration with protein adsorption. MATERIALS & METHODS: Four polymeric NPs systems possessing similar sizes (230 ± 20 nm) but varied ζ potentials (-30 ∼ +40 mv) were prepared...
October 10, 2017: Nanomedicine
Alberto Corona, Dario Cattaneo
No abstract text is available yet for this article.
September 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Roger L Nation, Samira M Garonzik, Visanu Thamlikitkul, Evangelos J Giamarellos-Bourboulis, Alan Forrest, David L Paterson, Jian Li, Fernanda P Silveira
No abstract text is available yet for this article.
September 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Raimondo Gaglio, Antonio Alfonzo, Nicola Francesca, Onofrio Corona, Rosalia Di Gerlando, Pietro Columba, Giancarlo Moschetti
The "Spiritu re fascitrari" (SRF) is a typical Sicilian distillate obtained from the by-products of traditional process of honey production. Although some alcoholic fermentation of honey based products have been described, the present research represents the first investigation on the yeast ecology and the physico-chemical characteristics of honey by-products subjected to an alcoholic fermentation followed by distillation. All samples collected during manufacturing process were analysed for the count of total, osmophilic and osmotolerant yeasts...
September 11, 2017: International Journal of Food Microbiology
Fatma Vatansever, Michael R Hamblin
New methods are needed for covalent functionalization of nanoparticles-surface with organic polymer coronas to generate polymeric nanocomposite in a controlled manner. Here we report the use of a surface-initiated polymerization approach, mediated by titanium (IV) catalysis, to grow poly(n-hexylisocyanate) chains from silica surface. Two pathways were used to generate the interfacing in these nano-hybrids. In the first one, the nanoparticles was "seeded" with SiCl4, followed by reaction with 1,6-hexanediol to form hydroxyl groups attached directly to the surface via O-Si-O bonding...
February 2017: Macromolecular Research
Sarah M Westberg, Stuart J Beatty, Andrea R Corona, Sarah Deines, Karen M Gunning, Holly E Gurgle, Haley S Holtan, Macary Weck Marciniak, Karen J McConnell, Melissa A Somma McGivney, Rachana J Patel
OBJECTIVE: To provide a guiding document describing residency training opportunities in ambulatory care for students, postgraduate year 1 (PGY1) residents, practicing pharmacists, and pharmacy educators. SUMMARY: Student pharmacists, residents, practitioners, and educators can benefit from a guiding document describing the various pathways to develop as an ambulatory care practitioner through residency training. The benefits and differences of PGY1 and postgraduate year 2 (PGY2) ambulatory care residency programs are included...
October 5, 2017: Journal of the American Pharmacists Association: JAPhA
Ana Laura Calderon-Garcidueñas, Charles Duyckaerts
Alzheimer disease neuropathology is characterized by the extracellular accumulation of Aβ peptide and intracellular aggregation of hyperphosphorylated tau. With the progression of the disease, macroscopic atrophy affects the entorhinal area and hippocampus, amygdala, and associative regions of the neocortex. The locus coeruleus is depigmented. The deposition of Aβ is first made of diffuse deposits. Amyloid focal deposits constitute the core of the senile plaque which also comprises a corona of tau-positive neurites...
2017: Handbook of Clinical Neurology
Yonggui Wang, Pedro B Groszewicz, Sabine Rosenfeldt, Hendrik Schmidt, Cynthia A Volkert, Philipp Vana, Torsten Gutmann, Gerd Buntkowsky, Kai Zhang
Self-assembly of nanoparticles (NPs) forming unique structures has been investigated extensively over the past few years. However, many self-assembled structures by NPs are irreversible, because they are generally constructed using their suspensions. It is still challenging for NPs to reversibly self-assemble in dry state, let alone of polymeric NPs with general sizes of hundreds of nm. Herein, this study reports a new reversible self-assembly phenomenon of NPs in dry state, forming thermoreversible strip-like supermolecular structures...
October 6, 2017: Advanced Materials
Navid Sobhani, Silvia Paola Corona, Deborah Bonazza, Anna Ianza, Tania Pivetta, Giandomenico Roviello, Maurizio Cortale, Alessandra Guglielmi, Fabrizio Zanconati, Daniele Generali
Malignant mesothelioma is a rare and aggressive form of cancer affecting the mesothelium. This mainly occupational disease is becoming more common in those countries where asbestos has been used for industrial applications. Notwithstanding the progress made in the field, patients do not survive more than 12 months on average with standard treatment. With the advent of next generation sequencing, it is now possible to study the mutational landscape of each tumor with the aim of identifying the genetic aberrations driving tumorigenesis...
October 6, 2017: Future Oncology
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