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https://www.readbyqxmd.com/read/28108320/modulation-on-brain-gray-matter-activity-and-white-matter-integrity-by-apoe-%C3%AE%C2%B54-risk-gene-in-cognitively-intact-elderly-a-multimodal-neuroimaging-study
#1
Suping Cai, Yuanyuan Jiang, Yubo Wang, Xiaoming Wu, Junchan Ren, Min Seob Lee, Sunghoon Lee, Liyu Huang
Apolipoprotein E (APOE) ε4 allele is the genetic risk factor with the most established evidence for sporadic Alzheimer's disease. Previous neuroimaging studies have demonstrated insufficiently consistent functional and structural changes among healthy APOE ε4 carriers when compared to non-carriers. Here, in a cognitively intact elderly group (a total of 110: 45 APOE ε4 carriers, 65 non-carriers), we aimed to investigate the potential role of APOE ε4 in the modulation of grey matter activity, white matter integrity, and brain morphology before the development of clinically significant symptoms and signs, by methods of: amplitude of low frequency fluctuations and regional homogeneity analysis based on resting state fMRI, and fiber tractography approach based on diffusion tensor imaging...
January 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28104305/cp39-cp75-and-cp91-are-major-structural-components-of-the-dictyostelium-centrosome-s-core-structure
#2
Irene Meyer, Tatjana Peter, Petros Batsios, Oliver Kuhnert, Anne Krüger-Genge, Carl Camurça, Ralph Gräf
The acentriolar Dictyostelium centrosome is a nucleus-associated body consisting of a core structure with three plaque-like layers, which are surrounded by a microtubule-nucleating corona. The core duplicates once per cell cycle at the G2/M transition, whereby its central layer disappears and the two outer layers form the mitotic spindle poles. Through proteomic analysis of isolated centrosomes, we have identified CP39 and CP75, two essential components of the core structure. Both proteins can be assigned to the central core layer as their centrosomal presence is correlated to the disappearance and reappearance of the central core layer in the course of centrosome duplication...
January 12, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28097874/through-scaffold-modification-to-3-5-diaryl-4-5-dihydroisoxazoles-new-potent-and-selective-inhibitors-of-monoamine-oxidase-b
#3
Rita Meleddu, Simona Distinto, Roberto Cirilli, Stefano Alcaro, Matilde Yanez, Maria Luisa Sanna, Angela Corona, Claudia Melis, Giulia Bianco, Peter Matyus, Filippo Cottiglia, Elias Maccioni
3,5-Diaryl-4,5-dihydroisoxazoles were synthesized and evaluated as monoamine oxidase (MAO) enzyme inhibitors and iron chelators. All compounds exhibited selective inhibitory activity towards the B isoform of MAO in the nanomolar concentration range. The best performing compound was preliminarily evaluated for its ability to bind iron II and III cations, indicating that neither iron II nor iron III is coordinated. The best compounds racemic mixtures were separated and single enantiomers inhibitory activity evaluated...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28095684/effect-of-the-protein-corona-on-antibody-antigen-binding-in-nanoparticle-sandwich-immunoassays
#4
Helena de Puig, Irene Bosch, Marc Carré-Camps, Kimberly Hamad-Schifferli
We investigated the effect of the protein corona on the function of nanoparticle (NP) antibody (Ab) conjugates in dipstick sandwich immunoassays. Ab specific for Zika virus nonstructural protein 1 (NS1) were conjugated to gold NPs, and another anti-NS1 Ab was immobilized onto the nitrocellulose membrane. Sandwich immunoassay formation was influenced by whether the strip was run in corona forming conditions, i.e., in human serum. Strips run in buffer or pure solutions of bovine serum albumin exhibited false positives, but those run in human serum did not...
January 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28094800/relationship-of-hyposalivation-and-xerostomia-in-mexican-elderly-with-socioeconomic-sociodemographic-and-dental-factors
#5
Horacio Islas-Granillo, Aida Borges-Yáñez, Miguel Ángel Fernández-Barrera, Leticia Ávila-Burgos, Nuria Patiño-Marín, María de Lourdes Márquez-Corona, Martha Mendoza-Rodríguez, Carlo Eduardo Medina-Solís
We determined the prevalence of hyposalivation and xerostomia in older Mexicans (≥60 years), and its relationship with diverse factors. A cross-sectional study was realized in elderly subjects from Pachuca, Mexico. Chewing-stimulated saliva was collected under standardized conditions and salivary flow was measured; subjects were considered to have hyposalivation if their stimulated salivary flow was less than 0.7 mL per minute. Xerostomia was evaluated by asking subjects 'Does your mouth feel dry?'. Hyposalivation was present in 59...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093297/bottom-up-synthesis-of-carbon-nanoparticles-with-higher-doxorubicin-efficacy
#6
Samer Bayda, Mohamad Hadla, Stefano Palazzolo, Vinit Kumar, Isabella Caligiuri, Emmanuele Ambrosi, Enrico Pontoglio, Marco Agostini, Tiziano Tuccinardi, Alvise Benedetti, Pietro Riello, Vincenzo Canzonieri, Giuseppe Corona, Giuseppe Toffoli, Flavio Rizzolio
Nanomedicine requires intelligent and non-toxic nanomaterials for real clinical applications. Carbon materials possess interesting properties but with some limitations due to toxic effects. Interest in carbon nanoparticles (CNPs) is increasing because they are considered green materials with tunable optical properties, overcoming the problem of toxicity associated with quantum dots or nanocrystals, and can be utilized as smart drug delivery systems. Using black tea as a raw material, we synthesized CNPs with a narrow size distribution, tunable optical properties covering visible to deep red absorption, non-toxicity and easy synthesis for large-scale production...
January 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28091644/chiral-bidentate-n-s-ferrocene-ligands-based-on-a-thiazoline-framework-synthesis-and-use-in-palladium-catalyzed-asymmetric-allylic-alkylation
#7
E P Sánchez-Rodríguez, F Hochberger-Roa, R Corona-Sánchez, J E Barquera-Lozada, R A Toscano, M Urrutigoïty, M Gouygou, M C Ortega-Alfaro, J G López-Cortés
An efficient method to obtain chiral 1,2-disubstituted ferrocenyl ligands has been developed. The introduction of planar chirality was accomplished by using 2-thiazoline as an ortho-directing lithiation group, and moreover, these kinds of ligands possess a central chirality from the amino alcohol used in their synthesis. The X-ray analysis and DFT calculations confirmed the diastereoselectivity of ortho-lithiation and the configuration of the planar chirality. The ability of these new bidentate [N,S]-ferrocene ligands to act in Pd-catalyzed asymmetric allylic alkylation has also been demonstrated and compared with their oxazoline counterparts...
January 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28090797/dimensions-of-attention-associated-with-the-microstructure-of-corona-radiata-white-matter
#8
Elise A Stave, Michael D De Bellis, Steven R Hooper, Donald P Woolley, Suk Ki Chang, Steven D Chen
Mirsky proposed a model of attention that included these dimensions: focus/execute, sustain, stabilize, encode, and shift. The neural correlates of these dimensions were investigated within corona radiata subregions in healthy youth. Diffusion tensor imaging and neuropsychological assessments were conducted in 79 healthy, right-handed youth aged 4-17 years. Diffusion tensor imaging maps were analyzed using standardized parcellation methods. Partial Pearson correlations between neuropsychological standardized scores, representing these attention dimensions, and diffusion tensor imaging measures of corona radiata subregions were calculated after adjusting for gender and IQ...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28089273/high-performance-liquid-chromatography-analysis-of-100-nm-liposomal-nanoparticles-using-polymer-coated-silica-monolithic-columns-with-aqueous-mobile-phase
#9
Naoki Itoh, Arato Kimoto, Eiichi Yamamoto, Tatsuya Higashi, Tomofumi Santa, Takashi Funatsu, Masaru Kato
Recently, nanoparticles have garnered considerable attention, and the demand for a rapid and simple method for their analysis has increased accordingly. The bimodal pores (few μm- and few tens nm-sized pores) of monolithic columns were thought to be suitable for the separation of nanoparticles and small molecules; however, the residual silanol groups on the column surface resulted in the strong adsorption of liposomes and hindered their analysis. To overcome this problem, we modified the surface of the silica monolith via a two-step process and developed three silica monolithic columns coated with three different polymers: glycidyl methacrylate (GMA), 2-hydroxyethyl methacrylate (HEMA), and N-vinylpyrrolidone (VP)...
December 29, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28087354/effect-of-piroxicam-on-lipid-membranes-drug-encapsulation-and-gastric-toxicity-aspects
#10
Natalia Wilkosz, Sami Rissanen, Małgorzata Cyza, Renata Szybka, Maria Nowakowska, Alex Bunker, Tomasz Róg, Mariusz Kepczynski
Uptake of piroxicam, a non-steroidal anti-inflammatory drug, from the intestines after oral intake is limited due to its low solubility and its wide use is associated with several side effects related to the gastrointestinal tract. In this study, all-atom molecular dynamics (MD) simulations and fluorescent spectroscopy were employed to investigate the interaction of piroxicam in neutral, zwitterionic, and cationic forms with lipid bilayers composed of phosphatidylcholine, cholesterol, and PEGylated lipids. Our study was aimed to assess the potential for encapsulation of piroxicam in liposomal carriers and to shed more light on the process of gastrointestinal tract injury by the drug...
January 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28075572/effect-of-protein-corona-on-silver-nanoparticle-stabilization-and-ion-release-kinetics-in-artificial-seawater
#11
Maja Levak, Petra Burić, Maja Dutour Sikirić, Darija Domazet Jurašin, Nevenka Mikac, Niko Bačić, Roland Drexel, Florian Meier, Željko Jakšić, Daniel Mark Lyons
In parallel with the growing use of nanoparticle-containing products, their release into the environment over the coming years is expected to increase significantly. With many large population centers located in near-coastal areas, and increasing evidence that various nanoparticles may be toxic to a range of organisms, biota in estuarine and coastal waters may be particularly vulnerable. While size effects may be important in cases, silver nanoparticles have been found to be toxic in large part due to their release of silver ions...
January 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28075126/cell-conditioned-protein-coronas-on-engineered-particles-influence-immune-responses
#12
Qiong Dai, Junling Guo, Yan Yan, Ching-Seng Ang, Nadja Bertleff-Zieschang, Frank Caruso
A protein corona, which forms on engineered particles as soon as they are introduced into biological environments, is known to provide particles with a "biological identity". Protein coronas derived from various biological environments have been demonstrated to alter the cell internalization mechanism, to diminish targeting ability and to induce nanoparticle aggregation. So far, most of these studies have challenged engineered particles with a static biological environment. However, the extracellular environment is highly dynamic due to the process termed "cell-conditioning", in which cells deplete and secrete biomolecules...
January 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28072497/covalently-connected-polymer-protein-nanostructures-fabricated-by-reactive-self-assembly-approach
#13
Hanying Zhao, Yuanyuan Ju, Cheng Xing, Dongxia Wu, Yunfang Wu, Lianyong Wang
In this research, covalently connected polymer-protein nanostructures were fabricated by reactive self-assembly approach. PtBMA-co-PPDSMA was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. Covalently connected nanostructures (CCNs) with hydrophobic polymer cores and hydrophilic protein coronae were prepared by adding PtBMA-co-PPDSMA/DMF solutions into bovine serum albumin (BSA) aqueous solutions. The thiol-disulfide exchange reaction between the pyridyl disulfide groups on the polymer chains and the thiol groups on the protein molecules plays a key role in the fabrication of CCNs...
January 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28071891/dual-enzymatic-reaction-assisted-gemcitabine-delivery-systems-for-programmed-pancreatic-cancer-therapy
#14
Haijie Han, Daniel Valdeperez, Qiao Jin, Bin Yang, Zuhong Li, Yulian Wu, Beatriz Pelaz, Wolfgang J J Parak, Jian Ji
Dual enzymatic reactions were introduced to fabricate programmed gemcitabine (GEM) nanovectors for targeted pancreatic cancer therapy. Dual-enzyme sensitive GEM nanovectors were prepared by conjugation of matrix metalloproteinase-9 (MMP-9) detachable poly(ethylene glycol) (PEG), cathepsin B cleavable GEM, and targeting ligand CycloRGD to CdSe/ZnS quantum dots (QDs). The GEM nanovectors decorated with PEG corona could avoid nonspecific interactions and exhibit prolonged blood circulation time. After GEM nanovectors were accumulated in tumor tissue by the enhanced permeability and retention (EPR) effect, the PEG corona can be removed by overexpressed MMP-9 in tumor tissue and RGD would be exposed, which was capable of facilitating cellular internalization...
January 10, 2017: ACS Nano
https://www.readbyqxmd.com/read/28070572/electrostatic-layer-by-layer-construction-of-fibrous-tmv-biofilms
#15
Brylee David B Tiu, Daniel L Kernan, Sicily B Tiu, Amy M Wen, Yi Zheng, Jonathan K Pokorski, Rigoberto C Advincula, Nicole F Steinmetz
As nature's choice in designing complex architectures, the bottom-up assembly of nanoscale building blocks offers unique solutions in achieving more complex and smaller morphologies with wide-ranging applications in medicine, energy, and materials science as compared to top-down manufacturing. In this work, we employ charged tobacco mosaic virus (TMV-wt and TMV-lys) nanoparticles in constructing multilayered fibrous networks via electrostatic layer-by-layer (LbL) deposition. In neutral aqueous media, TMV-wt assumes an anionic surface charge...
January 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28068290/a-collection-system-for-dry-solid-residues-from-exhaled-breath-for-analysis-via-atomic-force-microscopy
#16
Victor N Morozov, Andrey Y Mikheev
Exhaled air contains sub-micron droplets of lung liquid, which potentially bear biomarkers of lung diseases. After dehydration they form dry residue particles (DRPs). As a first step in developing techniques to characterize individual DRPs, a new electrostatic collector was designed in which DRPs are charged within a unipolar corona charger, concentrated in a cone funnel, and deposited onto a limited area of a highly oriented pyrolytic graphite surface. The collector captures 80%-90% of DRPs at an optimal flow rate of 0...
January 9, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28066707/longitudinal-changes-in-microstructural-white-matter-metrics-in-alzheimer-s-disease
#17
Chantel D Mayo, Erin L Mazerolle, Lesley Ritchie, John D Fisk, Jodie R Gawryluk
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Current avenues of AD research focus on pre-symptomatic biomarkers that will assist with early diagnosis of AD. The majority of magnetic resonance imaging (MRI) based biomarker research to date has focused on neuronal loss in grey matter and there is a paucity of research on white matter. METHODS: Longitudinal DTI data from the Alzheimer's Disease Neuroimaging Initiative 2 database were used to examine 1) the within-group microstructural white matter changes in individuals with AD and healthy controls at baseline and year one; and 2) the between-group microstructural differences in individuals with AD and healthy controls at both time points...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28065188/flavanone-rich-citrus-beverages-counteract-the-transient-decline-in-postprandial-endothelial-function-in-humans-a-randomised-controlled-double-masked-cross-over-intervention-study
#18
Catarina Rendeiro, Honglin Dong, Caroline Saunders, Laura Harkness, Melvin Blaze, Yanpeng Hou, Ronald L Belanger, Giulia Corona, Julie A Lovegrove, Jeremy P E Spencer
Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0-7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30-65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function...
December 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/28061390/wettability-and-surface-morphology-of-eroded-dentin-treated-with-chitosan
#19
Mirian Saavedra Ururahy, Fabiana Almeida Curylofo-Zotti, Rodrigo Galo, Lucas Fabricio Bahia Nogueira, Ana Paula Ramos, Silmara Aparecida Milori Corona
OBJECTIVE: To assess the effect of chitosan, at concentrations of 2.5% and 5.0%, on the wettability of the eroded dentin, followed by analysis of surface morphology by SEM. METHODS: 104 bovine dentin slabs were ground, polished and then immersed in 20mL of citric acid (pH=3.2) under continuous stirring for 2h. Specimens were randomly divided according to the dentin substrate: sound and eroded, and then, subdivided into 4 groups (n=10): without rewetting (control), 1% acetic acid, 2...
December 2, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/28059659/antiplatelet-therapy-for-the-prevention-of-peri-coiling-thromboembolism-in-high-risk-patients-with-ruptured-intracranial-aneurysms
#20
Nancy J Edwards, Wesley H Jones, Aditya Sanzgiri, Juan Corona, Mark Dannenbaum, Peng Roc Chen
OBJECTIVE The most frequent procedural complication of the endovascular treatment of intracranial aneurysms is a thromboembolic event (TEE); in a subset of patients, such events will cause permanent neurological disability. In patients with unruptured aneurysms, increasing evidence supports the use of periprocedural antiplatelet therapy to prevent TEEs. The object of this study was to evaluate whether patients with ruptured aneurysms and subarachnoid hemorrhage would also benefit from periprocedural antiplatelet therapy...
January 6, 2017: Journal of Neurosurgery
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