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https://www.readbyqxmd.com/read/28416241/circulating-tumor-dna-from-bench-to-bedside
#1
Joline S J Lim, Filip Janku, Timothy A Yap
In the era of personalized medicine, tumor sampling is paramount to enable the assessment of actionable molecular aberrations to help rationalize and guide treatment decisions. Longitudinal tracking of such aberrations may also be helpful to detect emerging drug resistance and to allow for timely modifications to ongoing therapies to improve patient outcomes. Nevertheless, tumor tissue sampling involves an invasive procedure with potential risks to patients and involves logistical challenges. As such, other less invasive and safer methods such as blood sampling for molecular profiling has been gaining traction...
March 1, 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/28301693/the-clue
#2
Tyler Tate
As I stood outside of Carlos's room, I felt caught on the horns of a dilemma. It seemed impossible to truly "be there" for Carlos without sacrificing my other intern duties. This tension pervaded much of my residency training, as I often found myself spending more time completing chart notes, answering pages, and giving sign out than I did at the bedside with my patients. I knew I had a duty to "do my job"-I could not let my team down. But what about my duty to Carlos, a duty to act on my intuition and try to "get to the bottom" of his illness, if that was even possible? And what about my thirteen other patients? Wasn't I was their doctor as well? I have spent countless hours studying the ethical frameworks for medical rationing...
March 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28298480/antimicrobial-stewardship-programmes-bedside-rationing-by-another-name
#3
Simon Oczkowski
Antimicrobial therapy is a cornerstone of therapy in critically ill patients; however, the wide use of antibiotics has resulted in increased antimicrobial resistance and outbreaks of resistant disease. To counter this, many hospitals have instituted antimicrobial stewardship programmes as a way to reduce the inappropriate use of antibiotics. However, uptake of antimicrobial stewardship programmes has been variable, as many clinicians fear that they may put individual patients at risk of treatment failure. In this paper, I argue that antimicrobial stewardship programmes are indeed a form of bedside rationing, and explore the risks and benefits of such programmes for individual patients in the intensive care unit, and the critically ill population in general...
March 15, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28225697/who-should-ration
#4
Philip M Rosoff
A principal component of physician decision making is judging what interventions are clinically appropriate. Due to the inexorable and steady increase of health care costs in the US, physicians are constantly being urged to exercise judicious financial stewardship with due regard for the financial implications of what they prescribe. When applied on a case-by-case basis, this otherwise reasonable approach can lead to either inadvertent or overt and arbitrary restriction of interventions for some patients rather than others on the basis of clinically irrelevant characteristics such as ethnicity, gender, age, or skin color...
February 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28127654/-postoperative-wound-infections-diagnosis-classification-and-treatment
#5
D Seidel, J Bunse
BACKGROUND: Surgical site infections are a frequent complication of surgery and a severe burden for the patient as well as for the healthcare system. Sound knowledge of the disease pattern is an essential prerequisite for effective therapy. OBJECTIVE: This article presents an overview of the diagnosis, classification and treatment options for surgical site infections. MATERIAL AND METHODS: Based on the existing experience, the currently available evidence and pathophysiological considerations, an overview of the diagnostic possibilities, the existing classification systems and the treatment options is presented...
January 26, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27874172/development-of-crizotinib-a-rationally-designed-tyrosine-kinase-inhibitor-for-non-small-cell-lung-cancer
#6
REVIEW
Candice C Poon, John J Kelly
Non-small cell lung cancer (NSCLC) is the number one cause of global mortality. Despite aggressive treatment, the prognosis is dismal. Patients with advanced NSCLC have a median survival of 4 months from the time of diagnosis. Fortunately, molecularly based approaches to drug discovery have yielded a tyrosine kinase inhibitor, crizotinib, which significantly prolongs median progression-free survival in a subset of patients. Although initial clinical trial results demonstrate crizotinib has a promising role to play in NSCLC treatment, development of resistance leaves much to be elucidated about how to effectively combat this deadly disease...
May 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27811591/similarities-and-differences-in-nurse-reported-care-rationing-between-critical-care-surgical-and-medical-specialties
#7
Megan Higgs, Ritin Fernandez, Suzanne Polis, Vicki Manning
OBJECTIVE: The aim of this study was to determine the similarities and differences in elements of nursing care that are commonly rationed in the critical care, medical, and surgical specialties within an acute hospital environment. METHODS: Registered nurses who provide bedside nursing care within the medical, surgical, and critical specialties at a single center were invited to anonymously complete the self-administered MISSCARE questionnaire. The frequency of rationing for each individual care element within the 4 broader care groups (assessment, intervention-individual needs, intervention-basic care, and planning) of the MISSCARE questionnaire was determined...
November 2, 2016: Journal of Patient Safety
https://www.readbyqxmd.com/read/27441603/from-bench-top-to-bedside-a-prospective-in-vitro-antibiotic-combination-testing-iact-service-to-guide-the-selection-of-rationally-optimized-antimicrobial-combinations-against-extensively-drug-resistant-xdr-gram-negative-bacteria-gnb
#8
Yiying Cai, Nathalie Grace Chua, Tze-Peng Lim, Jocelyn Qi-Min Teo, Winnie Lee, Asok Kurup, Tse-Hsien Koh, Thuan-Tong Tan, Andrea L Kwa
INTRODUCTION: Combination therapy is increasingly utilized against extensively-drug resistant (XDR) Gram negative bacteria (GNB). However, choosing a combination can be problematic as effective combinations are often strain-specific. An in vitro antibiotic combination testing (iACT) service, aimed to guide the selection of individualized and rationally optimized combination regimens within 48 hours, was developed. We described the role and feasibility of the iACT service in guiding individualized antibiotic combination selection in patients with XDR-GNB infections...
2016: PloS One
https://www.readbyqxmd.com/read/27393082/kinases-inhibitors-in-lung-cancer-from-benchside-to-bedside
#9
REVIEW
Pankaj Kumar Singh, Harpreet Singh, Om Silakari
Lung cancer still remains one of the major causes of cancer related mortality around the globe. Various different molecular targets have been discovered till date for targeting lung cancer. But not every new molecular target has a successfully designed inhibitor; moreover conventional chemotherapeutics have their own limitations such as toxicity and lack of selectivity. Thus, kinases still remain the most effective molecular target in lung cancer therapy. Also, once-shunned kinase inhibitors have recently acquired renewed interest after the development and approval of irreversible kinase inhibitors (such as afatinib) that form covalent bonds with cysteine (or other nucleophilic residues) in the ATP-binding pocket of the kinases...
August 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27173747/off-the-shelf-cellular-therapeutics-factors-to-consider-during-cryopreservation-and-storage-of-human-cells-for-clinical-use
#10
REVIEW
Erik J Woods, Sreedhar Thirumala, Sandhya S Badhe-Buchanan, Dominic Clarke, Aby J Mathew
The field of cellular therapeutics has immense potential, affording an exciting array of applications in unmet medical needs. One of several key issues is an emphasis on getting these therapies from bench to bedside without compromising safety and efficacy. The successful commercialization of cellular therapeutics will require many to extend the shelf-life of these therapies beyond shipping "fresh" at ambient or chilled temperatures for "just in time" infusion. Cryopreservation is an attractive option and offers potential advantages, such as storing and retaining patient samples in case of a relapse, banking large quantities of allogeneic cells for broader distribution and use and retaining testing samples for leukocyte antigen typing and matching...
June 2016: Cytotherapy
https://www.readbyqxmd.com/read/27169342/non-rinse-skin-cleansers-the-way-forward-in-preventing-incontinence-related-moisture-lesions
#11
RANDOMIZED CONTROLLED TRIAL
F J Harries, P A Begg
OBJECTIVE: The use of non-rinse skin cleansers in the care of patients who are at risk of tissue breakdown is not new within the National Health Service (NHS). Back to the Floor Continence Care Rounds (introduced in 2012 to facilitate bedside continence care education) at University Hospitals Birmingham had identified that in the current climate of austerity and efficiency savings, the use of non-rinse cleanser was being randomly rationed. Our objective was to determine whether the introduction of a smaller tube of non-rinse cleanser with targeted education would improve usage and ultimately improve the skin of incontinent patients...
May 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27115219/from-bench-to-bedside-molecular-imaging-in-inflammatory-bowel-diseases
#12
Raja Atreya, Markus F Neurath
PURPOSE OF REVIEW: Standard structural imaging procedures such as endoscopy, ultrasonography, or MRI are an integral part of the rational management of patients with inflammatory bowel diseases (IBDs). There is nevertheless the need for further refined imaging approaches that are able to overcome the limitations of currently used formats. The advent of molecular imaging modalities that allow real-time visualization of cellular processes not only in the preclinical setting but also in clinical trials has demonstrated its ability to improve current therapeutic strategies...
July 2016: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/27094104/from-monoclonal-antibodies-to-small-molecules-the-development-of-inhibitors-targeting-the-pd-1-pd-l1-pathway
#13
REVIEW
Mei-Miao Zhan, Xue-Qin Hu, Xiu-Xiu Liu, Ban-Feng Ruan, Jun Xu, Chenzhong Liao
Cancer immunotherapy has made an extraordinary journey from bench to bedside. Blocking the interactions between programmed cell death protein 1 (PD-1) and its ligand, PD-L1, has emerged as a promising immunotherapy for treating cancer. Here, we review the development of drugs targeting the PD-1/PD-L1 pathway. We discuss the monoclonal antibodies (mAbs) approved or in clinical trials, peptides and patented small molecules developed against this pathway. Such compounds have the potential to treat cancer as well as chronic virological diseases...
June 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27042832/critically-ill-allogeneic-hematopoietic-stem-cell-transplantation-patients-in-the-intensive-care-unit-reappraisal-of-actual-prognosis
#14
REVIEW
C Saillard, D Blaise, D Mokart
The outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients has significantly improved over the past decade. Still, a significant number of patients require intensive care unit (ICU) management because of life-threatening complications. Literature from the 1990s reported extremely poor prognosis for critically ill allo-HSCT patients requiring ICU management. Recent data justify the use of ICU resources in hematologic patients. Yet, allo-HSCT remains an independent variable associated with mortality...
August 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/26900912/impact-of-a-surgeon-led-peripherally-inserted-central-venous-catheter-team-on-peripherally-inserted-central-venous-catheter-related-complications-and-costs
#15
Luise I M Pernar, Lindsay L Wolf, Anupamaa Seshadri, Vihas Patel
BACKGROUND: Peripherally inserted central venous catheters (PICCs) are popular for a broad range of indications. As with other forms of central access, PICC use can be associated with serious and potentially costly complications. In 2000, in response to the rising popularity of PICC use, a surgeon-led team was created to steward their placement. All requests were screened rigorously to ensure rational use. Our hypothesis was that creation of a dedicated PICC team would decrease inappropriate PICC placement, overall complication rates, and cost...
June 2016: Surgical Infections
https://www.readbyqxmd.com/read/26689287/prx1-knockdown-potentiates-vitamin-k3-toxicity-in-cancer-cells-a-potential-new-therapeutic-perspective-for-an-old-drug
#16
Tiantian He, Elie Hatem, Laurence Vernis, Ming Lei, Meng-Er Huang
BACKGROUND: Many promising anticancer molecules are abandoned during the course from bench to bedside due to lack of clear-cut efficiency and/or severe side effects. Vitamin K3 (vitK3) is a synthetic naphthoquinone exhibiting significant in vitro and in vivo anticancer activity against multiple human cancers, and has therapeutic potential when combined with other anticancer molecules. The major mechanism for the anticancer activity of vitK3 is the generation of cytotoxic reactive oxygen species (ROS)...
2015: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/26598946/computational-oncology-mathematical-modelling-of-drug-regimens-for-precision-medicine
#17
REVIEW
Dominique Barbolosi, Joseph Ciccolini, Bruno Lacarelle, Fabrice Barlési, Nicolas André
Computational oncology is a generic term that encompasses any form of computer-based modelling relating to tumour biology and cancer therapy. Mathematical modelling can be used to probe the pharmacokinetics and pharmacodynamics relationships of the available anticancer agents in order to improve treatment. As a result of the ever-growing numbers of druggable molecular targets and possible drug combinations, obtaining an optimal toxicity-efficacy balance is an increasingly complex task. Consequently, standard empirical approaches to optimizing drug dosing and scheduling in patients are now of limited utility; mathematical modelling can substantially advance this practice through improved rationalization of therapeutic strategies...
April 2016: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/26467298/a-survey-of-ethiopian-physicians-experiences-of-bedside-rationing-extensive-resource-scarcity-tough-decisions-and-adverse-consequences
#18
Frehiwot Berhane Defaye, Dawit Desalegn, Marion Danis, Samia Hurst, Yemane Berhane, Ole Frithjof Norheim, Ingrid Miljeteig
BACKGROUND: Resource scarcity in health care is a universal challenge. In high-income settings, bedside rationing is commonly discussed and debated as a means to addressing scarcity. However, little is known about physicians' experiences in resource-limited contexts in low- income countries. Here we describe physicians' experiences regarding scarcity of resources, bedside rationing, use of various strategies to save resources, and perceptions of the consequences of rationing in Ethiopia...
2015: BMC Health Services Research
https://www.readbyqxmd.com/read/25993188/emerging-role-for-novel-immunotherapy-agents-in-metastatic-renal-cell-carcinoma-from-bench-to-bedside
#19
REVIEW
Matthew Weinstock, David F McDermott
Therapies that augment the antitumor immune response have been an established treatment modality for metastatic renal cell carcinoma (mRCC) since the 1980s. An improved understanding of the factors that limit the immune response to cancer have led to the development of novel therapeutic agents. Most notably, monoclonal antibodies that block the programmed death (PD)-1 immune checkpoint pathway have demonstrated encouraging antitumor activity against mRCC in phase I and II clinical trials. However, as monotherapy these agents are unlikely to offer substantial clinical benefit for the majority of patients with mRCC...
2015: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/25990431/bedside-predictors-of-difficult-intubation-a-systematic-review
#20
REVIEW
Andrea Vannucci, Laura F Cavallone
BACKGROUND: Unanticipated difficult intubation is associated with unwanted patient outcomes. The capability of predicting difficult airways may contribute to patient safety, efficient patient flow and rational use of limited resources. We evaluated current literature on performance of bedside airway tests in predicting difficult tracheal intubation. METHODS: Eligibility criteria were: prospective clinical studies; adult population of least 100 subjects; accepted definition of difficult intubation; direct laryngoscopy approach; true positive, false negative, false positive and true negative either reported or inferred...
January 2016: Minerva Anestesiologica
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