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https://www.readbyqxmd.com/read/29434729/a-composite-mouse-model-of-aplastic-anemia-complicated-with-iron-overload
#1
Dijiong Wu, Xiaowen Wen, Wenbin Liu, Linlong Xu, Baodong Ye, Yuhong Zhou
Iron overload is commonly encountered during the course of aplastic anemia (AA), but no composite animal model has been developed yet, which hinders drug research. In the present study, the optimal dosage and duration of intraperitoneal iron dextran injection for the development of an iron overload model in mice were explored. A composite model of AA was successfully established on the principle of immune-mediated bone marrow failure. Liver volume, peripheral hemogram, bone marrow pathology, serum iron, serum ferritin, pathological iron deposition in multiple organs (liver, bone marrow, spleen), liver hepcidin, and bone morphogenetic protein 6 (BMP6), SMAD family member 4 (SMAD4) and transferrin receptor 2 (TfR2) mRNA expression levels were compared among the normal control, AA, iron overload and composite model groups to validate the composite model, and explore the pathogenesis and features of iron overload in this model...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29411723/diagnostic-role-of-neutrophil-lymphocyte-ratio-in-oral-cavity-cancers
#2
M D Zl, R Karamert, H Tutar, M Şahin, A Türkcan, M Yılmaz
AIM: In this study, we aimed to evaluate the diagnostic role of neutrophil-lymphocyte ratio (NLR) and other hemogram parameters in differentiating nonmalignant oral cavity lesions from oral cavity cancers. METHODS: Ninety-five patients who were performed oral cavity biopsy between the years 2013 and 2015 were retrospectively reviewed. The control group comprised consecutive 70 patients who underwent septoplasty/septorhinoplasty procedures. Inclusion criteria were to be available with common blood count (CBC) just prior to procedure...
January 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29408596/clinical-and-immunological-profiles-of-anaemia-in-children-and-adolescents-with-plasmodium-vivax-malaria-in-the-par%C3%A3-state-brazilian-amazon
#3
Ana Maria Revoredo da Silva Ventura, Andrea Aparecida Moraes Fernandes, Graziela Maria Zanini, Lilian Rose Pratt-Riccio, Carina Guilhon Sequeira, Carlos Rodrigo Souza do Monte, Arnaldo Jorge Martins Filho, Ricardo Luiz Dantas Machado, Rosana Maria Feio Libonati, José Maria de Souza, Cláudio Tadeu Daniel-Ribeiro
Children and adolescents are at great risk for developing iron deficiency anaemia worldwide. In the tropical areas, malaria and intestinal parasites may also play an important role in anaemia pathogenesis. This study aimed at evaluating clinical and immunological aspects of anaemia in children and adolescents with Plasmodium vivax malaria, in the Pará State, Brazil. A longitudinal study was performed in two Reference Centres for malaria diagnosis in the Brazilian Amazon in children and adolescents with malaria (n = 81), as compared to a control group (n = 40)...
February 1, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29404160/spontaneous-splenic-rupture-in-the-early-postoperative-period-to-after-lobectomy
#4
Ayşe Gül Ergönül, Tevfik İlker Akçam, Ali Özdil, Ufuk Çağırıcı
Spontaneous splenic rupture is a quite rare entity that may develop secondary to some special situations (lymphoma, post-abdominal surgey etc). In the literature, the case of a patient has been reported following thoracic surgery. In a patient who had undergone right upper lobectomy for pulmonary carcinoma, signs of acute abdomen and low levels in the hemogram were detected on the fifth postoperative day; therefore, the patient underwent further investigations. A radiological evaluation revealed splenic rupture, and the patient was operated on...
April 2017: Turkish thoracic journal
https://www.readbyqxmd.com/read/29403202/thrombocytosis-in-children-clinico-hematological-profile-from-a-single-centre-in-eastern-india
#5
Rachita Sarangi, Sarita Pradhan, Avantika Dhanawat, Rashmi Patanayak, Gautam Benia
BACKGROUND AND OBJECTIVE: Thrombocytosis is not an uncommon finding in hemograms of children with an incidence of 6%-15% among hospitalized children. This study aims to determine the etiology of thrombocytosis and analyze various platelet parameters in children attending our hospital. MATERIALS AND METHODS: A prospective observational study was carried out in a tertiary care center in Odisha, in eastern part of India, for 6 months from July 2016 to December 2016...
January 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29401268/voluntary-intake-and-digestibility-by-sheep-of-alfalfa-ensiled-at-different-moisture-concentrations-following-fertilization-with-dairy-slurry
#6
J K Clark, K P Coffey, W K Coblentz, B C Shanks, J D Caldwell, R E Muck, D Philipp, M A Borchardt, R T Rhein, W E Jokela, E A Backes, M G Bertram, W B Smith
Dairy slurry is used commonly as an animal-sourced fertilizer in agronomic production. However, residual effects of slurry application on intake and digestibility of alfalfa (Medicago sativa L.) silage from subsequent harvests are not well known. The objective of this study was to determine if moisture concentration of alfalfa silage and timing of dairy slurry application relative to subsequent harvest affected intake and digestibility by sheep. Katahdin crossbred ewes (n = 18; 48 ± 5.3 kg) in mid-gestation were stratified by BW and allocated randomly in each of 2 periods to 1 of 6 treatments arranged in a 2 × 3 factorial arrangement...
February 1, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29382003/hemoglobin-hornchurch-%C3%AE-43-cd2-glu-lys-hbb-c-130g-a-in-a-chinese-boy-complicated-with-thrombocytopenia-a-case-report-and-literature-review
#7
Huiping Shi, Zhaoyue Wang
RATIONALE: Hemoglobin Hornchurch is regarded as an asymptomatic hemoglobinopathy with no obvious hematological or clinical abnormalities. Recently, we identified hemoglobin Hornchurch in a 13-year-old Chinese boy complicated with thrombocytopenia, which displayed instability in isopropanol precipitation test. PATIENT CONCERNS: In this case report, we reported a Chinese boy with hemoglobin Hornchurch complicated by thrombocytopenia. The patients have been misdiagnosed as aplastic anemia and myelodysplastic syndrome before...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29375053/expression-of-purinergic-p2x7-receptors-in-subpopulations-of-peripheral-blood-mononuclear-cells-in-early-stage-of-chronic-kidney-disease
#8
I Lajdova, A Oksa, M Horvathova, V Spustova
Chronic kidney disease (CKD) is known as a state of chronic low-grade inflammation, enhancing cardiovascular risk and immunodeficiency. Purinergic signaling has been accepted as a crucial component in the pathogenesis of various diseases, mediating a vast array of biological processes. The P2X7 receptor is one of the important cell surface regulators of several key inflammatory molecules. The aim of the study was to examine the expression of surface P2X7 receptors in subpopulations of peripheral blood mononuclear cells (PBMCs), and to evaluate the promising prognostic markers of inflammation (neutrophil/lymphocyte, Ne/Ly ratio) and cardiovascular risk (monocyte/high density lipoprotein cholesterol, Mo/HDL ratio) in early-stage CKD...
October 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29360147/carcinocythemia-first-report-in-a-cat-and-literature-review
#9
Eva Sá E Lemos, Hugo Lima de Carvalho, Rui M Gil da Costa, Nazaré Pinto da Cunha
A 6-year-old female neutered European Shorthair cat was presented with a 2-day history of lethargy and hyporexia. On physical examination, the cat was slightly depressed and had a 2.5 cm nodule in the left 3rd mammary gland. The hemogram revealed mild leukocytosis with mature neutrophilia and moderate thrombocytopenia. On blood smear evaluation, rare pleomorphic cells, possibly of epithelial origin, were observed mainly at the feathered edge. The animal died about 12 hours after presentation, and a necropsy was performed...
January 23, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29333812/markers-of-inflammation-and-tolerance-development-in-allergic-proctocolitis
#10
Hikmet T Nacaroglu, Semiha Bahceci Erdem, Ersin Durgun, Sait Karaman, Cahit Baris Erdur, Canan S Unsal Karkmer, Demet Can
BACKGROUND: Today, as a result of an increase in the frequency of food protein-induced allergic proctocolitis (FPIAP), there is a need for studies not only to enlighten the pathophysiology of the disease but also to determine simple, non-invasive markers in both diagnosis, and evaluation of the development of tolerance. No study has been found in the literature about the place of neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV), which are easy to calculate and non-invasive markers...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29310464/annals-express-unwanted-road-to-anemia-in-transthyretin-familial-amyloid-polyneuropathy-may-continue-irrespective-of-tafamidis-treatment
#11
Tokunori Ikeda, Teruaki Masuda, Mitsuharu Ueda, Taro Yamashita, Yohei Misumi, Satoru Shinriki, Yukio Ando
BACKGROUND: This retrospective longitudinal study was performed to determine whether tafamidis treatment leads to improvements in commonly used blood data for transthyretin familial amyloid polyneuropathy (TTR-FAP). METHODS: Commonly used blood data (complete blood count [including a hemogram], total protein, albumin, blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, γ-glutamyl transpeptidase, total bilirubin [T-Bil], creatine kinase, choline esterase, high density lipoprotein cholesterol, low density lipoprotein cholesterol, estimated glomerular filtration rate [eGFR], serum amyloid A protein, TTR, hemoglobin A1c, free triiodothyronine [FT3], and free thyroxine [FT4]) were investigated in 33 TTR-FAP patients...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29285056/effects-of-yak-activated-protein-on-hematopoiesis-and-related-cytokines-in-radiation-induced-injury-in-mice
#12
Yabin Duan, Xingchen Yao, Junbo Zhu, Yongping Li, Juanling Zhang, Xuejiao Zhou, Yijie Qiao, Meng Yang, Xiangyang Li
The aim of the present study was to investigate the protective effects of yak-activated protein on hematopoiesis and cytokine function in radiation-induced injury in mice. A total of 180 Kunming mice were randomly divided into three groups (A, B and C). Of these, 60 were randomly divided into a normal control group, a radiation model group, a positive control group and 3 yak-activated protein groups (high, medium and low dose groups; 10, 5 and 2.5 mg/kg, respectively). The other 120 mice were used for the subsequent experiments on days 7 and 14 following radiation...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29221152/distal-embolization-versus-combined-embolization-techniques-for-blunt-splenic-injuries-comparison-of-the-efficacy-and-complications
#13
Yon-Cheong Wong, Cheng-Hsien Wu, Li-Jen Wang, Huan-Wu Chen, Kuo-Ching Yuan, Being-Chuan Lin, Yu-Pao Hsu, Shih-Ching Kang
Comparable failure rates of distal or proximal transcatheter arterial embolization (TAE) techniques for blunt splenic injuries have been reported. This study is to investigate the efficacy and complication of combining both TAE techniques. We included 26 patients of blunt splenic injuries for TAE therapy and randomized them into distal TAE and combined TAE groups. A prospective study was performed to compare their demographics, clinical parameters, hemograms, post-TAE splenic infarct volumes, splenic abscess and pancreatitis between the two groups...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29208882/thrombocytopenia-in-late-onset-neonatal-sepsis-and-its-relationship-with-specific-organism-in-a-tertiary-care-hospital
#14
F Ahmed, A Y Raj, L N Begum
Late onset neonatal sepsis (LONS) is a common complication in the Neonatal Intensive Care Unit (NICU) especially in premature infants, in whom the clinical presentation can be subtle and nonspecific. Thrombocytopenia is an important complication of sepsis. The objective of the present study was to identify the organism-speci?c platelet response in neonate with culture proven LONS. In this retrospective study all the infants with blood culture positive LONS in the neonatal intensive care unit (NICU) at Square Hospitals Ltd...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29201765/association-of-severity-of-helicobacter-pylori-infection-with-peripheral-blood-neutrophil-to-lymphocyte-ratio-and-mean-platelet-volume
#15
Mustafa Guclu, A Faruq Agan
Aim: To determine the correlation of Helicobacter pylori infection with peripheral blood neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV). Materials and methods: The NLR, MPV, platelets, leukocytes, neutrophils, and lymphocytes were calculated and the differences between groups were investigated. Results: A total of 199 patients were included in the study. Neutrophil/lymphocyte ratio was statistically lower in H. pylori-positive patients than in H...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29179457/traditional-chinese-medicine-danggui-buxue-tang-inhibits-colorectal-cancer-growth-through-induction-of-autophagic-cell-death
#16
Shun-Ting Chen, Tzung-Yan Lee, Tung-Hu Tsai, Yu-Chuen Huang, Yin-Cheng Lin, Chin-Ping Lin, Hui-Ru Shieh, Ming-Ling Hsu, Chih-Wen Chi, Ming-Cheng Lee, Hen-Hong Chang, Yu-Jen Chen
Purpose: The induction of autophagic cell death is an important process in the development of anticancer therapeutics. We aimed to evaluate the activity of the ancient Chinese decoction Danggui Buxue Tang (DBT) against colorectal cancer (CRC) and the associated autophagy-related mechanism. Materials and methods: CT26 CRC cells were implanted into syngeneic BALB/c mice for the tumor growth assay. DBT extracts and DBT-PD (polysaccharide-depleted) fractions were orally administered...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29146407/-hemogram-profile-and-interest-of-pre-donation-hemoglobin-measurement-in-blood-donors-in-the-northwest-region-of-morocco
#17
S Bakrim, A Ouarour, K Jaidann, M Benajiba, A Masrar
BACKGROUND: Blood donation in Morocco and more particularly in the northwest region is carried out without prior determination of the pre-donation hemoglobin. In addition, we note the lack of scientific research that reports data on the red blood cells, leukocytes and platelet lines in donated blood at the regional or even national level. AIMS: To study hemogram profile in blood donors taken from the Northwest region of Morocco in order to provide decision makers of the National Center of Blood Transfusion and Hematology with valid scientific arguments to complete the criteria to donate whole blood, by the hemogram...
November 13, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29137105/urgent-laparoscopic-ureterolithotomy-for-proximal-ureter-stones-accompanied-with-obstructive-pyelonephritis-is-it-safe-and-effective-without-preoperative-drainage
#18
Huan Yang, Xiao Yu, Ejun Peng, Cong Li, Lei Cui, Xing Zeng, Shen Wang, Chao Wei, Zhihua Wang, Xiaolin Guo, Zhiqiang Chen, Zhangqun Ye, Shaogang Wang, Chenming Zhao
To evaluate the safety and efficacy of retroperitoneal laparoscopic ureterolithotomy (RLU) in the treatment of proximal ureteral stones accompanied with obstructive pyelonephritis without preoperative drainage.We retrospectively reviewed 21 cases of proximal ureteral stones with infected kidney undergoing RLU between July 2013 and September 2016. Stone-induced obstructive infected hydronephrosis was diagnosed using blood and urine tests and imaging modalities. Empirical effective broad spectrum antibiotic therapy was initiated immediately, and then urgent RLU was performed without preoperative drainage...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29128084/-chimerism-analysis-after-hematopoietic-cell-transplantation-guidelines-from-the-francophone-society-of-bone-marrow-transplantation-and-cellular-therapy-sfgm-tc
#19
Valérie Dubois, Mehdi Alizadeh, Jean Henri Bourhis, Pascaline Etancelin, Olivier Farchi, Christophe Ferrand, Laure Goursaud, Isabelle Mollet, Virginie Renac, Pauline Varlet, Ibrahim Yakoub-Agha, Jacques-Olivier Bay
Chimerism analysis is an important step for the patient follow-up after hematopoietic stem cell transplantation. It is used to quantify the donor and the recipient part of a cell population issued from blood or bone marrow sample. In addition to hemogram, this technique is necessary to appreciate the quality of engraftment. The aim of this article is to propose some recommendation about methods, result analysis and therapeutic decision in hematopoietic stem cell transplantation for malignant or non-malignant diseases...
November 8, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29115652/early-laparoscopic-cholecystectomy-following-acute-biliary-pancreatitis-expedites-recovery
#20
Seracettin Eğin, Metin Yeşiltaş, Berk Gökçek, Hakan Tezer, Servet Rüştü Karahan
BACKGROUND: In this retrospective study, we aimed to assess the reliability of early cholecystectomy, risk of recurrent biliary pancreatitis, and their effects on hospital length of stay and morbidity by comparing the results of early and late laparoscopic cholecystectomy in patients with acute biliary pancreatitis. METHODS: A total of 131 patients, who were diagnosed with acute biliary pancreatitis at Okmeydanı Education and Research Hospital in January 2009-December 2012, were included in the study...
November 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
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